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Kathy Wiley

Research Profile

Disorders

Prostatic Neoplasms

Physiology

Genes & Molecular Sequences

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Anatomy

Chromosomes, Human, Pair 8

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Publications

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Jianfeng Xu; S Lilly Zheng; Sarah D Isaacs; Kathy E Wiley; Fredrik Wiklund; Jielin Sun; A Karim Kader; Ge Li; Lina D Purcell; Seong-Tae Kim; Fang-Chi Hsu; Pär Stattin; Jonas Hugosson; Jan Adolfsson; Patrick C Walsh; Jeffrey M. Trent; David Duggan; John D Carpten; Henrik Grönberg; William B Isaacs
Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.
A Karim Kader; Jielin Sun; Sarah D Isaacs; Kathy E Wiley; Guifang Yan; Seong-Tae Kim; Helen Fedor; Angelo M DeMarzo; Jonathan I Epstein; Patrick C Walsh; Alan W Partin; Bruce J Trock; S Lilly Zheng; Jianfeng Xu; William B Isaacs
Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
Fang-Chi Hsu; Jielin Sun; Fredrik Wiklund; Sarah D Isaacs; Kathy E Wiley; Lina D Purcell; Zhengrong Gao; Pär Stattin; Yi Zhu; Seong-Tae Kim; Zheng Zhang; Wennuan Liu; Bao-Li Chang; Patrick C Walsh; David Duggan; John D Carpten; William B Isaacs; Henrik Grönberg; Jianfeng Xu; S Lilly Zheng
A novel prostate cancer susceptibility locus at 19q13.

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All Publications

2010: Jianfeng Xu; S Lilly Zheng; Sarah D Isaacs; Kathy E Wiley; Fredrik Wiklund; Jielin Sun; A Karim Kader; Ge Li; Lina D Purcell; Seong-Tae Kim; Fang-Chi Hsu; Pär Stattin; Jonas Hugosson; Jan Adolfsson; Patrick C Walsh; Jeffrey M. Trent; David Duggan; John D Carpten; Henrik Grönberg; William B Isaacs
Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(5):2136-40.
2009: A Karim Kader; Jielin Sun; Sarah D Isaacs; Kathy E Wiley; Guifang Yan; Seong-Tae Kim; Helen Fedor; Angelo M DeMarzo; Jonathan I Epstein; Patrick C Walsh; Alan W Partin; Bruce J Trock; S Lilly Zheng; Jianfeng Xu; William B Isaacs
Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
The Prostate 2009;69(11):1195-205.
2009: Fang-Chi Hsu; Jielin Sun; Fredrik Wiklund; Sarah D Isaacs; Kathy E Wiley; Lina D Purcell; Zhengrong Gao; Pär Stattin; Yi Zhu; Seong-Tae Kim; Zheng Zhang; Wennuan Liu; Bao-Li Chang; Patrick C Walsh; David Duggan; John D Carpten; William B Isaacs; Henrik Grönberg; Jianfeng Xu; S Lilly Zheng
A novel prostate cancer susceptibility locus at 19q13.
Cancer research 2009;69(7):2720-3.
2009: Wennuan Liu; Jishan Sun; Ge Li; Yi Zhu; Scott Zhang; Seong-Tae Kim; Jielin Sun; Fredrik Wiklund; Kathy E Wiley; Sarah D Isaacs; Pär Stattin; Jianfeng Xu; David Duggan; John D Carpten; William B Isaacs; Henrik Grönberg; S Lilly Zheng; Bao-Li Chang
Association of a germ-line copy number variation at 2p24.3 and risk for aggressive prostate cancer.
Cancer research 2009;69(6):2176-9.
2008: Jielin Sun; Bao-Li Chang; Sarah D Isaacs; Kathy E Wiley; Fredrik Wiklund; Pär Stattin; David Duggan; John D Carpten; Bruce J Trock; Alan W Partin; Patrick C Walsh; Henrik Grönberg; Jianfeng Xu; William B Isaacs; S Lilly Zheng
Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations.
The Prostate 2008;68(12):1257-62.
2008: Jielin Sun; Lina Purcell; Zhengrong Gao; Sarah D Isaacs; Kathy E Wiley; Fang-Chi Hsu; Wennuan Liu; David Duggan; John D Carpten; Henrik Grönberg; Jianfeng Xu; Bao-Li Chang; Alan W Partin; Patrick C Walsh; William B Isaacs; S Lilly Zheng
Association between sequence variants at 17q12 and 17q24.3 and prostate cancer risk in European and African Americans.
The Prostate 2008;68(7):691-7.
2008: Jielin Sun; Ethan M Lange; Sarah D Isaacs; Wennuan Liu; Kathy E Wiley; Leslie A Lange; Henrik Gronberg; David Duggan; John D Carpten; Patrick C Walsh; Jianfeng Xu; Bao-Li Chang; William B Isaacs; S Lilly Zheng
Chromosome 8q24 risk variants in hereditary and non-hereditary prostate cancer patients.
The Prostate 2008;68(5):489-97.
2007: S Lilly Zheng; Jielin Sun; Yu Cheng; Ge Li; Fang-Chi Hsu; Yi Zhu; Bao-Li Chang; Wennuan Liu; Jin Woo Kim; Aubrey R Turner; Marta Gielzak; Guifang Yan; Sarah D Isaacs; Kathy E Wiley; Jurga Sauvageot; Huann-Sheng Chen; Robin Gurganus; Leslie A Mangold; Bruce J Trock; Henrik Gronberg; David Duggan; John D Carpten; Alan W Partin; Patrick C Walsh; Jianfeng Xu; William B Isaacs
Association between two unlinked loci at 8q24 and prostate cancer risk among European Americans.
Journal of the National Cancer Institute 2007;99(20):1525-33.
2006: Junyan Xu; Jurga Sauvageot; Charles M Ewing; Jielin Sun; Wennuan Liu; Sarah D Isaacs; Kathy E Wiley; Lina Diaz; S Lilly Zheng; Patrick C Walsh; William B Isaacs
Germline ATBF1 mutations and prostate cancer risk.
The Prostate 2006;66(10):1082-5.
2006: Bao-Li Chang; Ethan M Lange; Latchezar Dimitrov; Christopher J Valis; Elizabeth M Gillanders; Leslie A Lange; Kathy E Wiley; Sarah D Isaacs; Fredrik Wiklund; Agnes B Baffoe-Bonnie; Carl D Langefeld; S Lilly Zheng; Mika P Matikainen; Tarja Ikonen; Henna Fredriksson; Teuvo Tammela; Patrick C Walsh; Joan E Bailey-Wilson; Johanna Schleutker; Henrik Gronberg; Kathleen Cooney; William B Isaacs; Edward Suh; Jeffrey M. Trent; Jianfeng Xu
Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect.
Human genetics 2006;118(6):716-24.
2006: S Lilly Zheng; Jeong-Ho Ju; Bao-Li Chang; Elizabeth Ortner; Jielin Sun; Sarah D Isaacs; Jishang Sun; Kathy E Wiley; Wennuan Liu; Micheas Zemedkun; Patrick C Walsh; James A Ferretti; James M Gruschus; William B Isaacs; Edward P Gelmann; Jianfeng Xu
Germ-line mutation of NKX3.1 cosegregates with hereditary prostate cancer and alters the homeodomain structure and function.
Cancer research 2006;66(1):69-77.
2005: Bao-Li Chang; Sarah D Isaacs; Kathy E Wiley; Elizabeth M Gillanders; S Lilly Zheng; Deborah A Meyers; Patrick C Walsh; Jeffrey M. Trent; Jianfeng Xu; William B Isaacs
Genome-wide screen for prostate cancer susceptibility genes in men with clinically significant disease.
The Prostate 2005;64(4):356-61.
2005: Bao-Li Chang; Elizabeth M Gillanders; Sarah D Isaacs; Kathy E Wiley; Tamara Adams; Aubrey R Turner; S Lilly Zheng; Deborah A Meyers; John D Carpten; Patrick C Walsh; Jeffrey M. Trent; Jianfeng Xu; William B Isaacs
Evidence for a general cancer susceptibility locus at 3p24 in families with hereditary prostate cancer.
Cancer letters 2005;219(2):177-82.
2005: Goutham Narla; Analisa Difeo; Helen L Reeves; Daniel J Schaid; Jennifer Hirshfeld; Eldad Hod; Amanda Katz; William B Isaacs; Scott J Hebbring; Akira Komiya; Shannon K McDonnell; Kathy E Wiley; Steven J Jacobsen; Sarah D Isaacs; Patrick C Walsh; S Lilly Zheng; Bao-Li Chang; Danielle M Friedrichsen; Janet L Stanford; Elaine A Ostrander; Arul M Chinnaiyan; Mark A Rubin; Jianfeng Xu; Stephen N Thibodeau; Scott L Friedman; John A Martignetti
A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk.
Cancer research 2005;65(4):1213-22.
2004: Gregory A Hawkins; Bao-Li Chang; S Lilly Zheng; Sarah D Isaacs; Kathy E Wiley; Eugene R Bleecker; Patrick C Walsh; Deborah A Meyers; Jianfeng Xu; William B Isaacs
Mutational analysis of PINX1 in hereditary prostate cancer.
The Prostate 2004;60(4):298-302.
2004: Elizabeth M Gillanders; Jianfeng Xu; Bao-Li Chang; Ethan M Lange; Fredrik Wiklund; Joan E Bailey-Wilson; Agnes B Baffoe-Bonnie; MaryPat Jones; Derek Gildea; Erica Riedesel; Julie Albertus; Sarah D Isaacs; Kathy E Wiley; Caroline E Mohai; Mika P Matikainen; Teuvo L J Tammela; S Lilly Zheng; W Mark Brown; Annika Rökman; John D Carpten; Deborah A Meyers; Patrick C Walsh; Johanna Schleutker; Henrik Gronberg; Kathleen Cooney; William B Isaacs; Jeffrey M. Trent
Combined genome-wide scan for prostate cancer susceptibility genes.
Journal of the National Cancer Institute 2004;96(16):1240-7.
2004: Jianfeng Xu; Carl D Langefeld; S Lilly Zheng; Elizabeth M Gillanders; Bao-Li Chang; Sarah D Isaacs; Adrienne H Williams; Kathy E Wiley; Latchezar Dimitrov; Deborah A Meyers; Patrick C Walsh; Jeffrey M. Trent; William B Isaacs
Interaction effect of PTEN and CDKN1B chromosomal regions on prostate cancer linkage.
Human genetics 2004;115(3):255-62.
2004: Bao-Li Chang; S Lilly Zheng; Sarah D Isaacs; Kathy E Wiley; Aubrey Turner; Ge Li; Patrick C Walsh; Deborah A Meyers; William B Isaacs; Jianfeng Xu
A polymorphism in the CDKN1B gene is associated with increased risk of hereditary prostate cancer.
Cancer research 2004;64(6):1997-9.
2004: Danielle M Friedrichsen; Janet L Stanford; Sarah D Isaacs; Marta Janer; Bao-Li Chang; Kerry Deutsch; Elizabeth M Gillanders; Suzanne Kolb; Kathy E Wiley; Michael D Badzioch; S Lilly Zheng; Patrick C Walsh; Gail P Jarvik; Leroy Hood; Jeffrey M. Trent; William B Isaacs; Elaine A Ostrander; Jianfeng Xu
Identification of a prostate cancer susceptibility locus on chromosome 7q11-21 in Jewish families.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):1939-44.
2004: W M Brown; Ethan M Lange; H Chen; S Lilly Zheng; Baoli Chang; Kathy E Wiley; Sarah D Isaacs; Patrick C Walsh; William B Isaacs; Jianfeng Xu; Kathleen Cooney
Hereditary prostate cancer in African American families: linkage analysis using markers that map to five candidate susceptibility loci.
British journal of cancer 2004;90(2):510-4.
2003: Jianfeng Xu; Elizabeth M Gillanders; Sarah D Isaacs; Bao-Li Chang; Kathy E Wiley; S Lilly Zheng; MaryPat Jones; Derek Gildea; Erica Riedesel; Julie Albertus; Diana Freas-Lutz; Carol Markey; Deborah A Meyers; Patrick C Walsh; Jeffrey M. Trent; William B Isaacs
Genome-wide scan for prostate cancer susceptibility genes in the Johns Hopkins hereditary prostate cancer families.
The Prostate 2003;57(4):320-5.
2003: Bao-Li Chang; S Lilly Zheng; Sarah D Isaacs; A Turner; Gregory A Hawkins; Kathy E Wiley; Eugene R Bleecker; Patrick C Walsh; Deborah A Meyers; William B Isaacs; Jianfeng Xu
Polymorphisms in the CYP1B1 gene are associated with increased risk of prostate cancer.
British journal of cancer 2003;89(8):1524-9.
2003: Bao-Li Chang; S Lilly Zheng; Sarah D Isaacs; Aubrey Turner; Gregory A Hawkins; Kathy E Wiley; Eugene R Bleecker; Patrick C Walsh; Deborah A Meyers; William B Isaacs; Jianfeng Xu
Polymorphisms in the CYP1A1 gene are associated with prostate cancer risk.
International journal of cancer. Journal international du cancer 2003;106(3):375-8.
2003: S Lilly Zheng; Josyf C Mychaleckyj; Gregory A Hawkins; Sarah D Isaacs; Kathy E Wiley; Aubrey Turner; Bao-Li Chang; Chris Von Kap-Herr; John D Carpten; Mark J Pettenati; Eugene R Bleecker; Patrick C Walsh; Jeffrey M. Trent; Deborah A Meyers; William B Isaacs; Jianfeng Xu
Evaluation of DLC1 as a prostate cancer susceptibility gene: mutation screen and association study.
Mutation research 2003;528(1-2):45-53.
2003: Jay D Pearson; Hsien-Hsien Lei; Terri H beaty; Kathy E Wiley; Sarah D Isaacs; William B Isaacs; Elizabeth Stoner; Patrick C Walsh
Familial aggregation of bothersome benign prostatic hyperplasia symptoms.
Urology 2003;61(4):781-5.
2003: Jianfeng Xu; S Lilly Zheng; Akira Komiya; Josyf C Mychaleckyj; Sarah D Isaacs; Baoli Chang; Aubrey R Turner; Charles M Ewing; Kathy E Wiley; Gregory A Hawkins; Eugene R Bleecker; Patrick C Walsh; Deborah A Meyers; William B Isaacs
Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk.
American journal of human genetics 2003;72(1):208-12.
2002: S Lilly Zheng; Bao-Li Chang; Dennis A Faith; Jill R Johnson; Sarah D Isaacs; Gregory A Hawkins; Aubrey Turner; Kathy E Wiley; Eugene R Bleecker; Patrick C Walsh; Deborah A Meyers; William B Isaacs; Jianfeng Xu
Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer risk.
Cancer research 2002;62(22):6485-8.
2002: Gregory A Hawkins; Scott D Cramer; S Lilly Zheng; Sarah D Isaacs; Kathy E Wiley; Bao-Li Chang; Eugene R Bleecker; Patrick C Walsh; Deborah A Meyers; William B Isaacs; Jianfeng Xu
Sequence variants in the human 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27B1) gene are not associated with prostate cancer risk.
The Prostate 2002;53(3):175-8.
2002: Gregory A Hawkins; Josyf C Mychaleckyj; S Lilly Zheng; Dennis A Faith; Brian Kelly; Sarah D Isaacs; Kathy E Wiley; Bao-Li Chang; Charles M Ewing; Piroska Bujnovszky; Eugene R Bleecker; Patrick C Walsh; Deborah A Meyers; William B Isaacs; Jianfeng Xu
Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk.
Cancer genetics and cytogenetics 2002;137(1):1-7.
2002: Jianfeng Xu; S Lilly Zheng; Aubrey Turner; Sarah D Isaacs; Kathy E Wiley; Gregory A Hawkins; Bao-Li Chang; Eugene R Bleecker; Patrick C Walsh; Deborah A Meyers; William B Isaacs
Associations between hOGG1 sequence variants and prostate cancer susceptibility.
Cancer research 2002;62(8):2253-7.
2002: Bao-Li Chang; S Lilly Zheng; Gregory A Hawkins; Sarah D Isaacs; Kathy E Wiley; Aubrey Turner; John D Carpten; Eugene R Bleecker; Patrick C Walsh; Jeffrey M. Trent; Deborah A Meyers; William B Isaacs; Jianfeng Xu
Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility.
Cancer research 2002;62(6):1784-9.
2002: Bao-Li Chang; S Lilly Zheng; Gregory A Hawkins; Sarah D Isaacs; Kathy E Wiley; Aubrey Turner; John D Carpten; Eugene R Bleecker; Patrick C Walsh; Jeffrey M. Trent; Deborah A Meyers; William B Isaacs; Jianfeng Xu
Polymorphic GGC repeats in the androgen receptor gene are associated with hereditary and sporadic prostate cancer risk.
Human genetics 2002;110(2):122-9.
2001: B Chang; S L Zheng; Sarah D Isaacs; Kathy E Wiley; John D Carpten; Gregory A Hawkins; Eugene R Bleecker; Patrick C Walsh; Jeffrey M. Trent; Deborah A Meyers; William B Isaacs; Jianfeng Xu
Linkage and association of CYP17 gene in hereditary and sporadic prostate cancer.
International journal of cancer. Journal international du cancer 2001;95(6):354-9.
2001: Jianfeng Xu; S Lilly Zheng; Gregory A Hawkins; Dennis A Faith; B Kelly; Sarah D Isaacs; Kathy E Wiley; Baoli Chang; Charles M Ewing; Piroska Bujnovszky; John D Carpten; Eugene R Bleecker; Patrick C Walsh; Jeffrey M. Trent; Deborah A Meyers; William B Isaacs
Linkage and association studies of prostate cancer susceptibility: evidence for linkage at 8p22-23.
American journal of human genetics 2001;69(2):341-50.
2001: S L Zheng; Jianfeng Xu; Sarah D Isaacs; Kathy E Wiley; B Chang; Eugene R Bleecker; Patrick C Walsh; Jeffrey M. Trent; Deborah A Meyers; William B Isaacs
Evidence for a prostate cancer linkage to chromosome 20 in 159 hereditary prostate cancer families.
Human genetics 2001;108(5):430-5.
2001: Jianfeng Xu; S Lilly Zheng; Baoli Chang; J R Smith; John D Carpten; O Colin Stine; Sarah D Isaacs; Kathy E Wiley; L Henning; Charles M Ewing; Piroska Bujnovszky; E R Bleeker; Patrick C Walsh; Jeffrey M. Trent; Deborah A Meyers; William B Isaacs
Linkage of prostate cancer susceptibility loci to chromosome 1.
Human genetics 2001;108(4):335-45.
2001: Jianfeng Xu; S Lilly Zheng; John D Carpten; Nina N Nupponen; Christiane M Robbins; J Mestre; Tracy Y Moses; Dennis A Faith; B D Kelly; Sarah D Isaacs; Kathy E Wiley; Charles M Ewing; Piroska Bujnovszky; Baoli Chang; Joan E Bailey-Wilson; Eugene R Bleecker; Patrick C Walsh; Jeffrey M. Trent; Deborah A Meyers; William B Isaacs
Evaluation of linkage and association of HPC2/ELAC2 in patients with familial or sporadic prostate cancer.
American journal of human genetics 2001;68(4):901-11.
1999: E P Wilkens; Diha Freije; J Xu; D R Nusskern; H Suzuki; Sarah D Isaacs; Kathy E Wiley; P Bujnovsky; Deborah A Meyers; Patrick C Walsh; William B Isaacs
No evidence for a role of BRCA1 or BRCA2 mutations in Ashkenazi Jewish families with hereditary prostate cancer.
The Prostate 1999;39(4):280-4.