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Michael Wiley

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Chemicals & Drugs

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Valentine J Klimkowski; Brian M Watson; Michael R Wiley; John W Liebeschuetz; Jeffry B Franciskovich; Jothirajah Marimuthu; Jolie A Bastian; Daniel J Sall; Jeffrey K Smallwood; Nikolay Y Chirgadze; Gerald F Smith; Ronald S Foster; Trelia J Craft; Philip Sipes; Marcia K Chastain; Scott M Sheehan
D-phenylglycinol-derived non-covalent factor Xa inhibitors: effect of non-peptidic S4 linkage elements on affinity and anticoagulant activity.
David Mendel; Angela L Marquart; Sajan Joseph; Philip Waid; Ying K Yee; Anne Louise Tebbe; Andrew M Ratz; David K Herron; Theodore Goodson; John J Masters; Jeffry B Franciskovich; Jennifer M Tinsley; Michael R Wiley; Leonard C Weir; Jeffrey A Kyle; Valentine J Klimkowski; Gerald F Smith; Richard D Towner; Larry L Froelich; John Buben; Trelia J Craft
Anthranilamide inhibitors of factor Xa.
Scott M Sheehan; Hans-Juergen Mest; Brian M Watson; Valentine J Klimkowski; David Timm; Annick Cauvin; Stephen H Parsons; Qing Shi; Emily J Canada; Michael R Wiley; Gerd Ruehter; Britta Evers; Soenke Petersen; Larry C Blaszczak; Shon R Pulley; Brandon J Margolis; Graham wishart; Beatrice Renson; Dirk Hankotius; Michael Mohr; Johann-Christian Zechel; J Michael Kalbfleisch; Elizabeth A Dingess-Hammond; Andre Boelke; Andreas Weichert
Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site.

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2007: Valentine J Klimkowski; Brian M Watson; Michael R Wiley; John W Liebeschuetz; Jeffry B Franciskovich; Jothirajah Marimuthu; Jolie A Bastian; Daniel J Sall; Jeffrey K Smallwood; Nikolay Y Chirgadze; Gerald F Smith; Ronald S Foster; Trelia J Craft; Philip Sipes; Marcia K Chastain; Scott M Sheehan
D-phenylglycinol-derived non-covalent factor Xa inhibitors: effect of non-peptidic S4 linkage elements on affinity and anticoagulant activity.
Bioorganic & medicinal chemistry letters 2007;17(21):5801-5.
2007: David Mendel; Angela L Marquart; Sajan Joseph; Philip Waid; Ying K Yee; Anne Louise Tebbe; Andrew M Ratz; David K Herron; Theodore Goodson; John J Masters; Jeffry B Franciskovich; Jennifer M Tinsley; Michael R Wiley; Leonard C Weir; Jeffrey A Kyle; Valentine J Klimkowski; Gerald F Smith; Richard D Towner; Larry L Froelich; John Buben; Trelia J Craft
Anthranilamide inhibitors of factor Xa.
Bioorganic & medicinal chemistry letters 2007;17(17):4832-6.
2007: Scott M Sheehan; Hans-Juergen Mest; Brian M Watson; Valentine J Klimkowski; David Timm; Annick Cauvin; Stephen H Parsons; Qing Shi; Emily J Canada; Michael R Wiley; Gerd Ruehter; Britta Evers; Soenke Petersen; Larry C Blaszczak; Shon R Pulley; Brandon J Margolis; Graham wishart; Beatrice Renson; Dirk Hankotius; Michael Mohr; Johann-Christian Zechel; J Michael Kalbfleisch; Elizabeth A Dingess-Hammond; Andre Boelke; Andreas Weichert
Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site.
Bioorganic & medicinal chemistry letters 2007;17(6):1765-8.
2005: Jeffry B Franciskovich; John J Masters; Jennifer M Tinsley; Trelia J Craft; Larry L Froelich; Donetta Gifford-Moore; Valentine J Klimkowski; Jeffrey K Smallwood; Gerald F Smith; Tommy Smith; Richard R Towner; Leonard C Weir; Michael R Wiley
Investigation of factor Xa inhibitors containing non-amidine S1 elements.
Bioorganic & medicinal chemistry letters 2005;15(21):4838-41.
2003: Scott M Sheehan; John J Masters; Michael R Wiley; Stephen C Young; John W Liebeschuetz; Stuart D Jones; Christopher W Murray; Jeffry B Franciskovich; David B Engel; Wayne W Weber; Jothirajah Marimuthu; Jeffrey A Kyle; Jeffrey K Smallwood; Mark W Farmen; Gerald F Smith
A four component coupling strategy for the synthesis of D-phenylglycinamide-derived non-covalent factor Xa inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(14):2255-9.
2000: John J Masters; Jeffry B Franciskovich; Jennifer M Tinsley; C Campbell; J B Campbell; Trelia J Craft; Larry L Froelich; Donetta Gifford-Moore; L A Hay; David K Herron; Valentine J Klimkowski; K D Kurz; J T Metz; Andrew M Ratz; RT Shuman; Gerald F Smith; Tommy Smith; Richard D Towner; Michael R Wiley; A Wilson; Ying K Yee
Non-amidine-containing 1,2-dibenzamidobenzene inhibitors of human factor Xa with potent anticoagulant and antithrombotic activity.
Journal of medicinal chemistry 2000;43(11):2087-92.
2000: Michael R Wiley; Leonard C Weir; S Briggs; N A Bryan; John Buben; C Campbell; Nikolay Y Chirgadze; R C Conrad; Trelia J Craft; James V Ficorilli; Jeffry B Franciskovich; Larry L Froelich; Donetta Gifford-Moore; Theodore Goodson; David K Herron; Valentine J Klimkowski; K D Kurz; Jeffrey A Kyle; John J Masters; Andrew M Ratz; G Milot; RT Shuman; Tommy Smith; Gerald F Smith; Anne Louise Tebbe; Jennifer M Tinsley
Structure-based design of potent, amidine-derived inhibitors of factor Xa: evaluation of selectivity, anticoagulant activity, and antithrombotic activity.
Journal of medicinal chemistry 2000;43(5):883-99.
2000: Ying K Yee; Anne Louise Tebbe; J H Linebarger; Douglas W Beight; Trelia J Craft; Donetta Gifford-Moore; Theodore Goodson; David K Herron; Valentine J Klimkowski; Jeffrey A Kyle; J Scott Sawyer; Gerald F Smith; Jennifer M Tinsley; Richard D Towner; Leonard C Weir; Michael R Wiley
N(2)-Aroylanthranilamide inhibitors of human factor Xa.
Journal of medicinal chemistry 2000;43(5):873-82.
2000: David K Herron; Theodore Goodson; Michael R Wiley; Leonard C Weir; Jeffrey A Kyle; Ying K Yee; Anne Louise Tebbe; Jennifer M Tinsley; David Mendel; John J Masters; Jeffry B Franciskovich; J Scott Sawyer; Douglas W Beight; Andrew M Ratz; G Milot; S E Hall; Valentine J Klimkowski; James H Wikel; Brian J Eastwood; Richard D Towner; Donetta Gifford-Moore; Trelia J Craft; Gerald F Smith
1,2-Dibenzamidobenzene inhibitors of human factor Xa.
Journal of medicinal chemistry 2000;43(5):859-72.
1999: Michael R Wiley; Leonard C Weir; Stephen L Briggs; Nikolay Y Chirgadze; David Clawson; Donetta Gifford-Moore; A L Schacht; Gerald F Smith; Vasu Vasudevan; LL Zornes; Valentine J Klimkowski
The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element.
Bioorganic & medicinal chemistry letters 1999;9(18):2767-72.