FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Myles Akabas

Research Profile

Anatomy

Oocytes

Physiology

Chemicals & Drugs

Living Beings

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Co-author Network

Publications

TOP 3
Myles H Akabas
Channels: Rotamers affect ion conductance.
I J Frame; Emilio F Merino; Vern L Schramm; Maria Cassera; Myles H Akabas
Malaria parasite type 4 equilibrative nucleoside transporters (ENT4) are purine transporters with distinct substrate specificity.
Moez Bali; Myles H Akabas
Gating-induced conformational rearrangement of the γ-aminobutyric acid type A receptor β-α subunit interface in the membrane-spanning domain.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Myles Akabas (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Myles H Akabas
Channels: Rotamers affect ion conductance.
Nature chemical biology 2012;8(12):953-4.
2012: I J Frame; Emilio F Merino; Vern L Schramm; Maria Cassera; Myles H Akabas
Malaria parasite type 4 equilibrative nucleoside transporters (ENT4) are purine transporters with distinct substrate specificity.
The Biochemical journal 2012;446(2):179-90.
2012: Moez Bali; Myles H Akabas
Gating-induced conformational rearrangement of the γ-aminobutyric acid type A receptor β-α subunit interface in the membrane-spanning domain.
The Journal of biological chemistry 2012;287(33):27762-70.
2012: Ben Collins; Elizabeth A Kane; David C Reeves; Myles H Akabas; Justin Blau
Balance of activity between LN(v)s and glutamatergic dorsal clock neurons promotes robust circadian rhythms in Drosophila.
Neuron 2012;74(4):706-18.
2012: Nicole K McKinnon; Moez Bali; Myles H Akabas
Length and amino acid sequence of peptides substituted for the 5-HT3A receptor M3M4 loop may affect channel expression and desensitization.
PloS one 2012;7(4):e35563.
2011: Myles H Akabas
Ion channels: Manipulating the munchies in mice.
Nature chemical biology 2011;7(11):759-60.
2011: Nicole K McKinnon; David C Reeves; Myles H Akabas
5-HT3 receptor ion size selectivity is a property of the transmembrane channel, not the cytoplasmic vestibule portals.
The Journal of general physiology 2011;138(4):453-66.
2011: Eric H Ekland; Myles H Akabas; Fidock David
Taking Charge: Feeding Malaria via Anion Channels.
Cell 2011;145(5):645-7.
2011: Rishi B Parikh; Moez Bali; Myles H Akabas
Structure of the M2 transmembrane segment of GLIC, a prokaryotic Cys loop receptor homologue from Gloeobacter violaceus, probed by substituted cysteine accessibility.
The Journal of biological chemistry 2011;286(16):14098-109.
2010: David Dahdal; David C Reeves; Marc Ruben; Myles H Akabas; Justin Blau
Drosophila pacemaker neurons require g protein signaling and GABAergic inputs to generate twenty-four hour behavioral rhythms.
Neuron 2010;68(5):964-77.
2010: Paul M Riegelhaupt; I J Frame; Myles H Akabas
Transmembrane segment 11 appears to line the purine permeation pathway of the Plasmodium falciparum equilibrative nucleoside transporter 1 (PfENT1).
The Journal of biological chemistry 2010;285(22):17001-10.
2010: Lawrence F Brass; Myles H Akabas; Linda D Burnley; David M Engman; Clayton A Wiley; Olaf S Andersen
Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs.
Academic medicine : journal of the Association of American Medical Colleges 2010;85(4):692-701.
2010: Paul M Riegelhaupt; Maria Cassera; Richard F G Fröhlich; Keith Z Hazleton; Jonathan J Hefter; Vern L Schramm; Myles H Akabas
Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1.
Molecular and biochemical parasitology 2010;169(1):40-9.
2009: Louis J Nkrumah; Paul M Riegelhaupt; Pedro Moura; David J Johnson; Jigar Patel; Karen Hayton; Michael T Ferdig; Thomas E Wellems; Myles H Akabas; Fidock David
Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE.
Molecular and biochemical parasitology 2009;165(2):122-31.
2009: Moez Bali; Michaela Jansen; Myles H Akabas
GABA-induced intersubunit conformational movement in the GABAA receptor alpha 1M1-beta 2M3 transmembrane subunit interface: experimental basis for homology modeling of an intravenous anesthetic binding site.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(10):3083-92.
2008: Maria Cassera; Keith Z Hazleton; Paul M Riegelhaupt; Emilio F Merino; Minkui Luo; Myles H Akabas; Vern L Schramm
Erythrocytic adenosine monophosphate as an alternative purine source in Plasmodium falciparum.
The Journal of biological chemistry 2008;283(47):32889-99.
2008: Rongbao Zhao; Andong Qiu; Eugenia Tsai; Michaela Jansen; Myles H Akabas; I David Goldman
The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.
Molecular pharmacology 2008;74(3):854-62.
2008: Michaela Jansen; Holger Rabe; Axelle Strehle; Sandra Dieler; Fabian Debus; Gerd Dannhardt; Myles H Akabas; Hartmut Lüddens
Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site.
Journal of medicinal chemistry 2008;51(15):4430-48.
2008: Michaela Jansen; Moez Bali; Myles H Akabas
Modular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loop.
The Journal of general physiology 2008;131(2):137-46.
2007: Andong Qiu; Sang Hee Min; Michaela Jansen; Usha Malhotra; Eugenia Tsai; Diane C Cabelof; Larry H Matherly; Rongbao Zhao; Myles H Akabas; I David Goldman
Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction.
American journal of physiology. Cell physiology 2007;293(5):C1669-78.
2007: Ayelet Rosen; Moez Bali; Jeffrey Horenstein; Myles H Akabas
Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment.
Biophysical journal 2007;92(9):3130-9.
2007: Moez Bali; Myles H Akabas
The location of a closed channel gate in the GABAA receptor channel.
The Journal of general physiology 2007;129(2):145-59.
2006: Andong Qiu; Michaela Jansen; Antoinette Sakaris; Sang Hee Min; Shrikanta Chattopadhyay; Eugenia Tsai; Claudio Sandoval; Rongbao Zhao; Myles H Akabas; I David Goldman
Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption.
Cell 2006;127(5):917-28.
2006: David C Reeves; David A Liebelt; Viswanathan Lakshmanan; Paul D Roepe; Fidock David; Myles H Akabas
Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms.
Molecular and biochemical parasitology 2006;150(2):288-99.
2006: Michaela Jansen; Myles H Akabas
State-dependent cross-linking of the M2 and M3 segments: functional basis for the alignment of GABAA and acetylcholine receptor M3 segments.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(17):4492-9.
2006: Myles H Akabas
Watching single protons bind.
Nature chemical biology 2006;2(3):128-30.
2005: Amal K Bera; Myles H Akabas
Spontaneous thermal motion of the GABA(A) receptor M2 channel-lining segments.
The Journal of biological chemistry 2005;280(42):35506-12.
2005: David C Reeves; Michaela Jansen; Moez Bali; Thomas Lemster; Myles H Akabas
A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(41):9358-66.
2005: Hugh C Hemmings; Myles H Akabas; Peter A Goldstein; James R Trudell; Beverley A Orser; Neil L Harrison
Emerging molecular mechanisms of general anesthetic action.
Trends in pharmacological sciences 2005;26(10):503-10.
2005: Jeffrey Horenstein; Paul Riegelhaupt; Myles H Akabas
Differential protein mobility of the gamma-aminobutyric acid, type A, receptor alpha and beta subunit channel-lining segments.
The Journal of biological chemistry 2005;280(2):1573-81.
2005: Sangwook Jung; Myles H Akabas; R Adron Harris
Functional and structural analysis of the GABAA receptor alpha 1 subunit during channel gating and alcohol modulation.
The Journal of biological chemistry 2005;280(1):308-16.
2004: Myles H Akabas
Na+/Ca2+ exchange inhibitors: potential drugs to mitigate the severity of ischemic injury.
Molecular pharmacology 2004;66(1):8-10.
2004: Eric N Goren; David C Reeves; Myles H Akabas
Loose protein packing around the extracellular half of the GABA(A) receptor beta1 subunit M2 channel-lining segment.
The Journal of biological chemistry 2004;279(12):11198-205.
2004: Myles H Akabas
GABAA receptor structure-function studies: a reexamination in light of new acetylcholine receptor structures.
International review of neurobiology 2004;62():1-43.
2004: Moez Bali; Myles H Akabas
Defining the propofol binding site location on the GABAA receptor.
Molecular pharmacology 2004;65(1):68-76.
2002: Amal K Bera; Maya Chatav; Myles H Akabas
GABA(A) receptor M2-M3 loop secondary structure and changes in accessibility during channel gating.
The Journal of biological chemistry 2002;277(45):43002-10.
2002: Daniel B Williams; Myles H Akabas
Structural evidence that propofol stabilizes different GABA(A) receptor states at potentiating and activating concentrations.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(17):7417-24.
2002: Myles H Akabas
Probing CFTR channel structure and function using the substituted-cysteine-accessibility method.
Methods in molecular medicine 2002;70():159-74.
2001: David C Reeves; E N Goren; Myles H Akabas; Sarah C R Lummis
Structural and electrostatic properties of the 5-HT3 receptor pore revealed by substituted cysteine accessibility mutagenesis.
The Journal of biological chemistry 2001;276(45):42035-42.
2001: D B Williams; Myles H Akabas
Evidence for distinct conformations of the two alpha 1 subunits in diazepam-bound GABA(A) receptors.
Neuropharmacology 2001;41(5):539-45.
2001: Jeffrey Horenstein; David A Wagner; Cynthia Czajkowski; Myles H Akabas
Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment.
Nature neuroscience 2001;4(5):477-85.
2000: D B Williams; Myles H Akabas
Benzodiazepines induce a conformational change in the region of the gamma-aminobutyric acid type A receptor alpha(1)-subunit M3 membrane-spanning segment.
Molecular pharmacology 2000;58(5):1129-36.
2000: Myles H Akabas
Cystic fibrosis transmembrane conductance regulator. Structure and function of an epithelial chloride channel.
The Journal of biological chemistry 2000;275(6):3729-32.
1999: D B Williams; Myles H Akabas
Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptors.
Biophysical journal 1999;77(5):2563-74.
1999: Romain Guinamard; Myles H Akabas
Arg352 is a major determinant of charge selectivity in the cystic fibrosis transmembrane conductance regulator chloride channel.
Biochemistry 1999;38(17):5528-37.
1998: Myles H Akabas
Channel-lining residues in the M3 membrane-spanning segment of the cystic fibrosis transmembrane conductance regulator.
Biochemistry 1998;37(35):12233-40.
1998: Jeffrey Horenstein; Myles H Akabas
Location of a high affinity Zn2+ binding site in the channel of alpha1beta1 gamma-aminobutyric acidA receptors.
Molecular pharmacology 1998;53(5):870-7.
1998: Arthur Karlin; Myles H Akabas
Substituted-cysteine accessibility method.
Methods in enzymology 1998;293():123-45.
1997: Myles H Akabas; M Cheung; Romain Guinamard
Probing the structural and functional domains of the CFTR chloride channel.
Journal of bioenergetics and biomembranes 1997;29(5):453-63.
1997: M Cheung; Myles H Akabas
Locating the anion-selectivity filter of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.
The Journal of general physiology 1997;109(3):289-99.
1996: M Cheung; Myles H Akabas
Identification of cystic fibrosis transmembrane conductance regulator channel-lining residues in and flanking the M6 membrane-spanning segment.
Biophysical journal 1996;70(6):2688-95.
1996: M Xu; Myles H Akabas
Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit.
The Journal of general physiology 1996;107(2):195-205.
1996: Z P Sun; Myles H Akabas; E H Goulding; Arthur Karlin; Steven A Siegelbaum
Exposure of residues in the cyclic nucleotide-gated channel pore: P region structure and function in gating.
Neuron 1996;16(1):141-9.
1995: Arthur Karlin; Myles H Akabas
Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins.
Neuron 1995;15(6):1231-44.
1995: M Xu; D F Covey; Myles H Akabas
Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants.
Biophysical journal 1995;69(5):1858-67.
1995: Myles H Akabas; Arthur Karlin
Identification of acetylcholine receptor channel-lining residues in the M1 segment of the alpha-subunit.
Biochemistry 1995;34(39):12496-500.
1994: Myles H Akabas; C Kaufmann; P Archdeacon; Arthur Karlin
Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit.
Neuron 1994;13(4):919-27.
1994: Myles H Akabas; C Kaufmann; T A Cook; P Archdeacon
Amino acid residues lining the chloride channel of the cystic fibrosis transmembrane conductance regulator.
The Journal of biological chemistry 1994;269(21):14865-8.
1994: Arthur Karlin; Myles H Akabas; C Czajkowski; C Kaufmann; D Stauffer; M Xu
Structures involved in binding, gating, and conduction in nicotinic acetylcholine receptors.
Renal physiology and biochemistry 1994;17(3-4):184-6.
1993: M Xu; Myles H Akabas
Amino acids lining the channel of the gamma-aminobutyric acid type A receptor identified by cysteine substitution.
The Journal of biological chemistry 1993;268(29):21505-8.
1992: Myles H Akabas; D A Stauffer; M Xu; Arthur Karlin
Acetylcholine receptor channel structure probed in cysteine-substitution mutants.
Science (New York, N.Y.) 1992;258(5080):307-10.
1991: Qais Al-Awqati; Donald W Landry; Myles H Akabas; C Redhead; A Edelman; J Edwards
Purification of the epithelial Cl channel.
Advances in experimental medicine and biology 1991;290():235-8; discussion 238-40.
1990: Myles H Akabas; Jane Dodd; Qais Al-Awqati
Identification of electrophysiologically distinct subpopulations of rat taste cells.
The Journal of membrane biology 1990;114(1):71-8.
1990: Myles H Akabas
Mechanisms of chemosensory transduction in taste cells.
International review of neurobiology 1990;32():241-79.
1990: Donald W Landry; Myles H Akabas; C Redhead; Qais Al-Awqati
Purification and reconstitution of epithelial chloride channels.
Methods in enzymology 1990;191():572-83.
1989: Donald W Landry; Myles H Akabas; C Redhead; A Edelman; E J Cragoe; Qais Al-Awqati
Purification and reconstitution of chloride channels from kidney and trachea.
Science (New York, N.Y.) 1989;244(4911):1469-72.
1989: Fredric S Cohen; Walter Niles; Myles H Akabas
Fusion of phospholipid vesicles with a planar membrane depends on the membrane permeability of the solute used to create the osmotic pressure.
The Journal of general physiology 1989;93(2):201-10.
1988: Myles H Akabas; Jane Dodd; Qais Al-Awqati
A bitter substance induces a rise in intracellular calcium in a subpopulation of rat taste cells.
Science (New York, N.Y.) 1988;242(4881):1047-50.
1984: Myles H Akabas; Fredric S Cohen; Alan Finkelstein
Separation of the osmotically driven fusion event from vesicle-planar membrane attachment in a model system for exocytosis.
The Journal of cell biology 1984;98(3):1063-71.
1984: Fredric S Cohen; Myles H Akabas; J Zimmerberg; Alan Finkelstein
Parameters affecting the fusion of unilamellar phospholipid vesicles with planar bilayer membranes.
The Journal of cell biology 1984;98(3):1054-62.
1982: Fredric S Cohen; Myles H Akabas; Alan Finkelstein
Osmotic swelling of phospholipid vesicles causes them to fuse with a planar phospholipid bilayer membrane.
Science (New York, N.Y.) 1982;217(4558):458-60.