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Robert Wilkinson

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Chemicals & Drugs

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Physiology

Membrane Fluidity

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Russell G Roberts; Christopher P F Redfern; Kenneth A Graham; K Bartlett; Robert Wilkinson; Timothy H J Goodship
Sodium bicarbonate treatment and ubiquitin gene expression in acidotic human subjects with chronic renal failure.
Nicholas J M Fardon; Robert Wilkinson; Trevor H Thomas
Abnormalities in primary granule exocytosis in neutrophils from Type I diabetic patients with nephropathy.
N J Fardon; Robert Wilkinson; Trevor H Thomas
Rapid fusion of granules with neutrophil cell membranes in hypertensive patients may increase vascular damage.

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All Publications

2002: Russell G Roberts; Christopher P F Redfern; Kenneth A Graham; K Bartlett; Robert Wilkinson; Timothy H J Goodship
Sodium bicarbonate treatment and ubiquitin gene expression in acidotic human subjects with chronic renal failure.
European journal of clinical investigation 2002;32(7):488-92.
2002: Nicholas J M Fardon; Robert Wilkinson; Trevor H Thomas
Abnormalities in primary granule exocytosis in neutrophils from Type I diabetic patients with nephropathy.
Clinical science (London, England : 1979) 2002;102(1):69-75.
2001: N J Fardon; Robert Wilkinson; Trevor H Thomas
Rapid fusion of granules with neutrophil cell membranes in hypertensive patients may increase vascular damage.
American journal of hypertension 2001;14(9 Pt 1):927-33.
2001: Paul A Mead; Robert Wilkinson; Trevor H Thomas
Na/Li countertransport abnormalities in type 1 diabetes with and without nephropathy are familial.
Diabetes care 2001;24(3):527-32.
2001: S L Watkins; IC West; Robert Wilkinson; Trevor H Thomas
Abnormal thiol reactivity of tropomyosin in essential hypertension and its association with abnormal sodium-lithium countertransport kinetics.
Journal of hypertension 2001;19(3):485-93.
1999: Paul A Mead; Robert Wilkinson; Trevor H Thomas
Thiol protein defect in sodium-lithium countertransport in subset of essential hypertension.
Hypertension 1999;34(6):1275-80.
1998: P A Mead; Robert Wilkinson; S H Pearce
The odyssey of a patient with hypocalciuric hypercalcaemia: pitfalls to consider.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1998;13(5):1300-5.
1998: Trevor H Thomas; Peter A Rutherford; K Vareesangthip; Robert Wilkinson; IC West
Erythrocyte membrane thiol proteins associated with changes in the kinetics of Na/Li countertransport: a possible molecular explanation of changes in disease.
European journal of clinical investigation 1998;28(4):259-65.
1998: K Vareesangthip; Robert Wilkinson; Trevor H Thomas
Lack of function of an N-ethylmaleimide-sensitive thiol protein in erythrocyte membrane of autosomal dominant polycystic kidney disease.
Journal of the American Society of Nephrology : JASN 1998;9(1):1-8.
1997: Peter A Rutherford; Trevor H Thomas; Robert Wilkinson
Na-Li countertransport kinetics in the relatives of hypertensive patients with abnormal Na-Li countertransport activity.
Biochemical and molecular medicine 1997;62(1):106-12.
1997: K Vareesangthip; P Tong; Robert Wilkinson; Trevor H Thomas
Insulin resistance in adult polycystic kidney disease.
Kidney international 1997;52(2):503-8.
1996: S N Sturgiss; Robert Wilkinson; J M Davison
Renal reserve during human pregnancy.
The American journal of physiology 1996;271(1 Pt 2):F16-20.
1996: K L Ho; Peter A Rutherford; Trevor H Thomas; Robert Wilkinson
Abnormal sodium-lithium countertransport kinetics in immunoglobulin A nephropathy patients and the families: association with hypertension.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1996;27(3):334-40.
1996: K Vareesangthip; Trevor H Thomas; P Tong; Robert Wilkinson
Erythrocyte membrane fluidity in adult polycystic kidney disease: difference between intact cells and ghost membranes.
European journal of clinical investigation 1996;26(2):171-3.
1996: T R Ringrose; Trevor H Thomas; Robert Wilkinson
Increased mononuclear cell membrane fluidity and increased B lymphocyte HLA class I expression in IgA nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1996;11(2):287-92.
1996: J G Anderton; Trevor H Thomas; Robert Wilkinson
Increased susceptibility to membrane lipid peroxidation in renal failure.
Nephron 1996;74(2):373-7.
1996: Peter A Rutherford; Trevor H Thomas; J O'Kelly; IC West; Robert Wilkinson
Thiol group control of sodium-lithium countertransport kinetics in uraemia: evidence of a membrane abnormality affected by haemodialysis.
Nephron 1996;72(2):184-8.
1996: C Catalano; Timothy H J Goodship; Kenneth A Graham; C Marino; A L Brown; J S Tapson; M K Ward; Robert Wilkinson
Withdrawal of renal replacement therapy in Newcastle upon Tyne: 1964-1993.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1996;11(1):133-9.
1995: K Vareesangthip; Trevor H Thomas; Robert Wilkinson
Abnormal effect of thiol groups on erythrocyte Na/Li countertransport kinetics in adult polycystic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1995;10(12):2219-23.
1995: Trevor H Thomas; IC West; Robert Wilkinson
Modification of erythrocyte Na+/Li+ countertransport kinetics by two types of thiol group.
Biochimica et biophysica acta 1995;1235(2):317-22.
1995: Trevor H Thomas; Peter A Rutherford; IC West; Robert Wilkinson
Sulphydryl group control of sodium-lithium countertransport kinetics: a membrane protein control abnormality in essential hypertension.
European journal of clinical investigation 1995;25(4):235-40.
1995: P Tong; T Thomas; T Berrish; David Humphriss; L Barriocanal; M Stewart; Mark Walker; Robert Wilkinson; K G M M Alberti
Cell membrane dynamics and insulin resistance in non-insulin-dependent diabetes mellitus.
Lancet 1995;345(8946):357-8.
1995: D Reaich; Kenneth A Graham; S M Channon; C Hetherington; C M Scrimgeour; Robert Wilkinson; Timothy H J Goodship
Insulin-mediated changes in PD and glucose uptake after correction of acidosis in humans with CRF.
The American journal of physiology 1995;268(1 Pt 1):E121-6.
1995: K K Ho; Trevor H Thomas; Peter A Rutherford; Robert Wilkinson
Sodium-lithium countertransport kinetics in IgA nephropathy: relation to plasma lipids and renal impairment.
Nephron 1995;69(4):391-6.
1994: P Tong; T Thomas; Robert Wilkinson
Membrane fluidity is different in intact erythrocytes and ghost membranes.
Biochemical medicine and metabolic biology 1994;52(2):132-5.
1994: I Adalet; T Hawkins; F Clark; Robert Wilkinson
Thallium-technetium-subtraction scintigraphy in secondary hyperparathyroidism.
European journal of nuclear medicine 1994;21(6):509-13.
1994: A Dowd; Trevor H Thomas; R Taylor; Robert Wilkinson
Erythrocyte sodium-lithium countertransport activity is related to membrane fluidity in IDDM patients.
Diabetologia 1994;37(4):394-400.
1994: Nicholas Argent; J Liles; D Rodham; C B Clayton; Robert Wilkinson; Peter H Baylis
A new method for measuring the blood volume of the rat using 113mIndium as a tracer.
Laboratory animals 1994;28(2):172-5.
1994: Peter A Rutherford; Trevor H Thomas; R Taylor; Robert Wilkinson
Nephropathy and changes in sodium-lithium countertransport kinetics in type 2 (non-insulin-dependent) diabetes mellitus.
Journal of human hypertension 1994;8(1):29-35.
1993: P H Winocour; C Catalano; Trevor H Thomas; Robert Wilkinson; K G M M Alberti
Increased red cell sodium lithium countertransport activity, total exchangeable sodium, and hormonal control of sodium balance in normoalbuminuric type 1 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 1993;10(9):825-32.
1993: Peter A Rutherford; Trevor H Thomas; Timothy Hardman; A F Lant; Robert Wilkinson
Sodium-lithium countertransport activity is not affected by short-term insulin exposure in vivo or in a physiologic medium in vitro.
Metabolism: clinical and experimental 1993;42(9):1087-9.
1993: D Reaich; S M Channon; C M Scrimgeour; S E Daley; Robert Wilkinson; Timothy H J Goodship
Correction of acidosis in humans with CRF decreases protein degradation and amino acid oxidation.
The American journal of physiology 1993;265(2 Pt 1):E230-5.
1993: S Macphail; Trevor H Thomas; Robert Wilkinson; J M Davison; W Dunlop
Erythrocyte sodium lithium countertransport in normal and hypertensive pregnancy: relation to haemodynamic changes.
British journal of obstetrics and gynaecology 1993;100(7):673-8.
1993: A Dowd; Trevor H Thomas; Robert Wilkinson
Increased human erythrocyte sodium-lithium countertransport in hyperlipidaemic patients may indicate increased membrane lipid fluidity.
European journal of clinical investigation 1993;23(2):102-7.
1993: N F Redwood; Robert Wilkinson; N A G Jones
Vomiting caused by a dialysis fluid 'pseudocyst'.
The British journal of surgery 1993;80(2):224.
1993: C Catalano; P H Winocour; Trevor H Thomas; Mark Walker; C F Sum; Robert Wilkinson; K G M M Alberti
Erythrocyte sodium-lithium countertransport activity and total body insulin-mediated glucose disposal in normoalbuminuric normotensive type 1 (insulin-dependent) diabetic patients.
Diabetologia 1993;36(1):52-6.
1993: Timothy H J Goodship; J Pablick-Deetjen; M K Ward; Robert Wilkinson
Adequacy of dialysis and nutritional status in CAPD.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1993;8(12):1366-71.
1992: Peter A Rutherford; Trevor H Thomas; M F Laker; Robert Wilkinson
Plasma lipids affect maximum velocity not sodium affinity of human sodium-lithium countertransport: distinction from essential hypertension.
European journal of clinical investigation 1992;22(11):719-24.
1992: Nicholas Argent; Robert Wilkinson; Peter H Baylis
Metabolic clearance rate of arginine vasopressin in severe chronic renal failure.
Clinical science (London, England : 1979) 1992;83(5):583-7.
1992: P H Winocour; Trevor H Thomas; L Brown; MF Laker; Robert Wilkinson; K G M M Alberti
Serum triglyceride and insulin levels are associated with erythrocyte sodium-lithium counter-transport activity in normoglycaemic individuals.
Clinica chimica acta; international journal of clinical chemistry 1992;208(3):193-203.
1992: Peter A Rutherford; Trevor H Thomas; S J Carr; R Taylor; Robert Wilkinson
Changes in erythrocyte sodium-lithium countertransport kinetics in diabetic nephropathy.
Clinical science (London, England : 1979) 1992;82(3):301-7.
1992: Peter A Rutherford; Trevor H Thomas; S J Carr; R Taylor; Robert Wilkinson
Kinetics of sodium-lithium countertransport activity in patients with uncomplicated type 1 diabetes.
Clinical science (London, England : 1979) 1992;82(3):291-9.
1992: Peter A Rutherford; Trevor H Thomas; S MacPhail; Robert Wilkinson
Sodium-lithium countertransport kinetics in normal and hypertensive human pregnancy.
European journal of clinical investigation 1992;22(1):50-4.
1992: Peter A Rutherford; D Veale; T Ashcroft; A R Morley; G John Gibson; Robert Wilkinson
Mesangiocapillary glomerulonephritis as the presenting feature of cryptogenic organizing pneumonitis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1992;7(10):1043-6.
1992: A L Brown; Paul A Corris; T Ashcroft; Robert Wilkinson
Azathioprine-related interstitial pneumonitis in a renal transplant recipient.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1992;7(4):362-4.
1992: I al-Khursany; Trevor H Thomas; K Harrison; Robert Wilkinson
Reduced erythrocyte and leukocyte magnesium is associated with cyclosporin treatment and hypertension in renal transplant patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1992;7(3):251-5.
1991: Peter A Rutherford; Trevor H Thomas; Robert Wilkinson
Insulin resistance and hypertension--implications for treatment.
Postgraduate medical journal 1991;67(792):869-75.
1991: Roger Freeman; F Kate Gould; Robert Wilkinson; A C Ward; N F Lightfoot; P R Sisson
Rapid inter-strain comparison by pyrolysis mass spectrometry of coagulase-negative staphylococci from persistent CAPD peritonitis.
Epidemiology and infection 1991;106(2):239-46.
1991: S J Carr; Trevor H Thomas; M F Laker; Robert Wilkinson
Lipid lowering therapy leads to a reduction in sodium-lithium countertransport activity.
Atherosclerosis 1991;87(2-3):103-8.
1991: Nicholas Argent; L M Burrell; Timothy H J Goodship; Robert Wilkinson; Peter H Baylis
Osmoregulation of thirst and vasopressin release in severe chronic renal failure.
Kidney international 1991;39(2):295-300.
1991: D Heseltine; Trevor H Thomas; Robert Wilkinson; O F James; John Potter
Erythrocyte sodium, potassium and sodium fluxes with cell and subject ageing.
Clinica chimica acta; international journal of clinical chemistry 1991;196(1):41-7.
1991: J Main; Trevor H Thomas; Robert Wilkinson
Haemodialysis: effects on white and red blood cell sodium content and transport.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1991;6(2):91-7.
1990: S Macphail; Trevor H Thomas; Robert Wilkinson; J M Davison; W Dunlop
A serial study of erythrocyte sodium content and sodium pump kinetics in pregnancy.
Clinical science (London, England : 1979) 1990;79(6):631-8.
1990: Trevor H Thomas; S Macphail; V Mott; Robert Wilkinson
Relationship between the maximum velocity and sodium affinity of the erythrocyte sodium pump and its rate constant in blood.
Clinical science (London, England : 1979) 1990;79(6):625-30.
1990: Nicholas Argent; Peter H Baylis; Robert Wilkinson
Immunoreactive vasopressin in end stage renal failure.
Clinica chimica acta; international journal of clinical chemistry 1990;190(3):185-8.
1990: Peter A Rutherford; Trevor H Thomas; Robert Wilkinson
Increased erythrocyte sodium-lithium countertransport activity in essential hypertension is due to an increased affinity for extracellular sodium.
Clinical science (London, England : 1979) 1990;79(4):365-9.
1990: Nicholas Argent; Robert Wilkinson; Peter H Baylis
Local hormones in the kidney: protectors of the kidney against the body?
The Journal of endocrinology 1990;126(3):351-4.
1990: S Carr; J C Mbanya; T Thomas; P Keavey; R Taylor; K G Alberti; Robert Wilkinson
Increase in glomerular filtration rate in patients with insulin-dependent diabetes and elevated erythrocyte sodium-lithium countertransport.
The New England journal of medicine 1990;322(8):500-5.
1990: S J Carr; Trevor H Thomas; M F Laker; Robert Wilkinson
Elevated sodium-lithium countertransport: a familial marker of hyperlipidaemia and hypertension?
Journal of hypertension 1990;8(2):139-46.
1990: J Main; T Thomas; Robert Wilkinson
Sodium content and transport of white and red blood cells in undialysed uraemic and continuous ambulatory peritoneal dialysis patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1990;5(5):369-75.
1990: Timothy H J Goodship; S Arfeen; A Kirkwood; Robert Wilkinson; M K Ward
Amino acid dialysate.
Contributions to nephrology 1990;85():84-91.
1989: H Mansy; Timothy H J Goodship; J S Tapson; G H Hartley; P Keavey; Robert Wilkinson
Effect of a high protein diet in patients with the nephrotic syndrome.
Clinical science (London, England : 1979) 1989;77(4):445-51.
1989: A Heaton; R Taylor; D G Johnston; M K Ward; Robert Wilkinson; K G M M Alberti
Hepatic and peripheral insulin action in chronic renal failure before and during continuous ambulatory peritoneal dialysis.
Clinical science (London, England : 1979) 1989;77(4):383-8.
1989: Jean-Claude Mbanya; Trevor H Thomas; R Taylor; K G M M Alberti; Robert Wilkinson
Increased proximal tubular sodium reabsorption in hypertensive patients with type 2 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 1989;6(7):614-20.
1989: J Main; Robert Wilkinson
Early renal artery occlusion after enalapril in atheromatous renal artery stenosis.
BMJ (Clinical research ed.) 1989;299(6695):394.
1989: J Main; Trevor H Thomas; Robert Wilkinson
Problems in measuring human leucocyte cation content: effects of cell preparation and handling.
Clinical science (London, England : 1979) 1989;77(2):157-60.
1989: A K Salahudeen; Trevor H Thomas; L Sellars; S Tapster; P Keavey; John R Farndon; I D Johnston; Robert Wilkinson
Hypertension and renal dysfunction in primary hyperparathyroidism: effect of parathyroidectomy.
Clinical science (London, England : 1979) 1989;76(3):289-96.
1989: R E Ferner; D Wilson; J R Paterson; Robert Wilkinson; M D Rawlins
The effects of intradermal bradykinin are potentiated by angiotensin converting enzyme inhibitors in hypertensive patients.
British journal of clinical pharmacology 1989;27(3):337-42.
1989: S J Carr; Trevor H Thomas; Robert Wilkinson
Erythrocyte sodium-lithium countertransport in primary and renal hypertension: relation to family history.
European journal of clinical investigation 1989;19(1):101-6.
1989: Trevor H Thomas; H Mansy; Robert Wilkinson
Erythrocyte sodium and sodium flux in relation to hypertension in chronic renal failure.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1989;4(1):21-6.
1989: R S Rodger; W L Sheldon; M J Watson; J H Dewar; Robert Wilkinson; M K Ward; D N Kerr
Zinc deficiency and hyperprolactinaemia are not reversible causes of sexual dysfunction in uraemia.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1989;4(10):888-92.
1988: Trevor H Thomas; Jean-Claude Mbanya; R Taylor; K G M M Alberti; Robert Wilkinson
Hypertension and diabetes mellitus: erythrocyte electrolytes and the effect of captopril treatment.
Journal of human hypertension 1988;2(4):229-34.
1988: S Carr; Trevor H Thomas; Robert Wilkinson
Sodium-lithium countertransport activity and its sensitivity to inhibitors with erythrocyte ageing in man.
Clinica chimica acta; international journal of clinical chemistry 1988;178(1):51-8.
1988: Jean-Claude Mbanya; Trevor H Thomas; Robert Wilkinson; K G M M Alberti; R Taylor
Hypertension and hyperinsulinaemia: a relation in diabetes but not essential hypertension.
Lancet 1988;1(8588):733-4.
1988: J S Tapson; H Mansy; Robert Wilkinson
End-stage renal failure due to multiple myeloma--poor survival on peritoneal dialysis.
The International journal of artificial organs 1988;11(1):39-42.
1988: E C Wijeyesinghe; T Hawkins; P M Keavey; Robert Wilkinson
An evaluation of technetium-99m tin colloid--its value in the diagnosis of renal transplant rejection.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1988;3(2):209-13.
1988: J S Tapson; A W Hodson; S M Marshall; Robert Wilkinson
Urinary enzyme excretion after donor nephrectomy.
Nephron 1988;48(2):126-31.
1987: J S Tapson; R S Rodger; H Mansy; R W Elliott; M K Ward; Robert Wilkinson
Renal replacement therapy in patients aged over 60 years.
Postgraduate medical journal 1987;63(746):1071-7.
1987: Timothy H J Goodship; S Lloyd; M B Clague; K Bartlett; M K Ward; Robert Wilkinson
Whole body leucine turnover and nutritional status in continuous ambulatory peritoneal dialysis.
Clinical science (London, England : 1979) 1987;73(5):463-9.
1987: Timothy H J Goodship; S Lloyd; P W McKenzie; M Earnshaw; I Smeaton; K Bartlett; M K Ward; Robert Wilkinson
Short-term studies on the use of amino acids as an osmotic agent in continuous ambulatory peritoneal dialysis.
Clinical science (London, England : 1979) 1987;73(5):471-8.
1987: T W J Lennard; M Venning; P K Donnelly; R G Wilson; N R Parrott; R W Elliott; G Proud; John R Farndon; M K Ward; Robert Wilkinson
Conversion of immunosuppression in renal allograft recipients from cyclosporine A to azathioprine and prednisolone 6 months after transplantation.
Transplantation proceedings 1987;19(5):3594-6.
1987: J S Tapson; P M Hepplewhite; Robert Wilkinson
Experience with the Travenol ultraviolet germicidal exchange system.
Contributions to nephrology 1987;57():167-71.
1987: H Mansy; D Patel; J S Tapson; J Fernandez; S Tapster; A D Torrance; Robert Wilkinson
Four methods to recruit renal functional reserve.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1987;2(4):228-32.
1986: J S Tapson; H Mansy; Roger Freeman; Robert Wilkinson
The high morbidity of CAPD fungal peritonitis--description of 10 cases and review of treatment strategies.
The Quarterly journal of medicine 1986;61(235):1047-53.
1986: R S Rodger; M J Watson; L Sellars; Robert Wilkinson; M K Ward; D N Kerr
Hypothalamic-pituitary-adrenocortical suppression and recovery in renal transplant patients returning to maintenance dialysis.
The Quarterly journal of medicine 1986;61(235):1039-46.
1986: A Heaton; R S Rodger; L Sellars; T H Goodship; K Fletcher; N Nikolakakis; M K Ward; Robert Wilkinson; D N Kerr
Continuous ambulatory peritoneal dialysis after the honeymoon: review of experience in Newcastle 1979-84.
British medical journal (Clinical research ed.) 1986;293(6552):938-41.
1986: J S Tapson; H Mansy; S M Marshall; S R Tisdall; Robert Wilkinson
Renal functional reserve in kidney donors.
The Quarterly journal of medicine 1986;60(231):725-32.
1985: R S Rodger; L Morrison; J H Dewar; Robert Wilkinson; M K Ward; D N Kerr
Loss of pulsatile luteinising hormone secretion in men with chronic renal failure.
British medical journal (Clinical research ed.) 1985;291(6509):1598-600.
1984: T H Goodship; A Heaton; R S Rodger; M K Ward; Robert Wilkinson; D N Kerr
Factors affecting development of peritonitis in continuous ambulatory peritoneal dialysis.
British medical journal (Clinical research ed.) 1984;289(6457):1485-6.
1984: Robert Wilkinson; A K Salahudeen; P Keavey; T Hawkins
Anaemia and dialysis.
Lancet 1984;1(8368):112-3.
1984: R S Rodger; K Fletcher; J H Dewar; D Genner; M McHugh; Robert Wilkinson; M K Ward; D N Kerr
Prevalence and pathogenesis of impotence in one hundred uremic men.
Uremia investigation 1984;8(2):89-96.
1984: A K Salahudeen; L Sellars; L N Murthy; D M Francis; P K Donnelly; T Hawkins; Robert Wilkinson
Extrarenal arteriovenous fistula. An unusual complication of percutaneous renal transplant biopsy.
Nephron 1984;37(1):64-5.
1983: A K Salahudeen; P M Keavey; T Hawkins; Robert Wilkinson
Is anaemia during continuous ambulatory peritoneal dialysis really better than during haemodialysis?
Lancet 1983;2(8358):1046-9.