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Cindy Will

Research Profile

Anatomy

Physiology

RNA Splicing

Chemicals & Drugs

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Publications

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Sina Mozaffari-Jovin; Karine F Santos; Henning Urlaub; Markus C Wahl; Cindy L Will; He-Hsuan Hsiao; Reinhard Lührmann
The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA.
Cyrille Girard; Klaus Hartmuth; Berthold Kastner; Ira Lemm; Evgeny M Makarov; Jianhe Peng; Henning Urlaub; Cindy L Will; Reinhard Lührmann
Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion.
Dmitry E Agafonov; Sergey Bessonov; Jochen Deckert; Peter Odenwälder; Henning Urlaub; Cindy L Will; Elmar Wolf; Reinhard Lührmann
Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method.

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All Publications

2012: Sina Mozaffari-Jovin; Karine F Santos; Henning Urlaub; Markus C Wahl; Cindy L Will; He-Hsuan Hsiao; Reinhard Lührmann
The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA.
Genes & development 2012;26(21):2422-34.
2012: Cyrille Girard; Klaus Hartmuth; Berthold Kastner; Ira Lemm; Evgeny M Makarov; Jianhe Peng; Henning Urlaub; Cindy L Will; Reinhard Lührmann
Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion.
Nature communications 2012;3():994.
2011: Dmitry E Agafonov; Sergey Bessonov; Jochen Deckert; Peter Odenwälder; Henning Urlaub; Cindy L Will; Elmar Wolf; Reinhard Lührmann
Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method.
Molecular and cellular biology 2011;31(13):2667-82.
2011: Cindy L Will; Reinhard Lührmann
Spliceosome structure and function.
Cold Spring Harbor perspectives in biology 2011;3(7):.
2010: Michael Grote; Elmar Wolf; Cindy L Will; Ira Lemm; Dmitry E Agafonov; Adrian Schomburg; Wolfgang Fischle; Henning Urlaub; Reinhard Lührmann
Molecular architecture of the human Prp19/CDC5L complex.
Molecular and cellular biology 2010;30(9):2105-19.
2010: Marc Schneider; Cindy L Will; Maria Anokhina; Jamal Tazi; Henning Urlaub; Reinhard Lührmann
Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes.
Molecular cell 2010;38(2):223-35.
2010: Jens Verbeeren; Elina H Niemelä; Janne J Turunen; Cindy L Will; Janne J Ravantti; Reinhard Lührmann; Mikko J Frilander
An ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing.
Molecular cell 2010;37(6):821-33.
2010: Marc Schneider; He-Hsuan Hsiao; Cindy L Will; Régis Giet; Henning Urlaub; Reinhard Lührmann
Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation.
Nature structural & molecular biology 2010;17(2):216-21.
2008: Sergey Bessonov; Maria Anokhina; Cindy L Will; Henning Urlaub; Reinhard Lührmann
Isolation of an active step I spliceosome and composition of its RNP core.
Nature 2008;452(7189):846-50.
2007: Nastaran Behzadnia; Monika M Golas; Klaus Hartmuth; Bjoern Sander; Berthold Kastner; Jochen Deckert; Prakash Dube; Cindy L Will; Henning Urlaub; Holger Stark; Reinhard Lührmann
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.
The EMBO journal 2007;26(6):1737-48.
2007: Gizem Dönmez; Klaus Hartmuth; Berthold Kastner; Cindy L Will; Reinhard Lührmann
The 5' end of U2 snRNA is in close proximity to U1 and functional sites of the pre-mRNA in early spliceosomal complexes.
Molecular cell 2007;25(3):399-411.
2007: Christian Merz; Henning Urlaub; Cindy L Will; Reinhard Lührmann
Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment.
RNA (New York, N.Y.) 2007;13(1):116-28.
2006: Nastaran Behzadnia; Klaus Hartmuth; Cindy L Will; Reinhard Lührmann
Functional spliceosomal A complexes can be assembled in vitro in the absence of a penta-snRNP.
RNA (New York, N.Y.) 2006;12(9):1738-46.
2006: Jochen Deckert; Klaus Hartmuth; Daniel Boehringer; Nastaran Behzadnia; Cindy L Will; Berthold Kastner; Holger Stark; Henning Urlaub; Reinhard Lührmann
Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions.
Molecular and cellular biology 2006;26(14):5528-43.
2006: Olexandr Dybkov; Cindy L Will; Jochen Deckert; Nastaran Behzadnia; Klaus Hartmuth; Reinhard Lührmann
U2 snRNA-protein contacts in purified human 17S U2 snRNPs and in spliceosomal A and B complexes.
Molecular and cellular biology 2006;26(7):2803-16.
2006: Roberta Spadaccini; Ulrich Reidt; Olexandr Dybkov; Cindy L Will; Ronald Frank; Gunter Stier; Lorenzo Corsini; Markus C Wahl; Reinhard Lührmann; Michael Sattler
Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing.
RNA (New York, N.Y.) 2006;12(3):410-25.
2005: Heike Benecke; Reinhard Lührmann; Cindy L Will
The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein.
The EMBO journal 2005;24(17):3057-69.
2005: Cindy L Will; Reinhard Lührmann
Splicing of a rare class of introns by the U12-dependent spliceosome.
Biological chemistry 2005;386(8):713-24.
2005: Monika M Golas; Bjoern Sander; Cindy L Will; Reinhard Lührmann; Holger Stark
Major conformational change in the complex SF3b upon integration into the spliceosomal U11/U12 di-snRNP as revealed by electron cryomicroscopy.
Molecular cell 2005;17(6):869-83.
2004: Claudia Schneider; Cindy L Will; Jürgen Brosius; Mikko J Frilander; Reinhard Lührmann
Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(26):9584-9.
2004: Olga V Makarova; Evgeny M Makarov; Henning Urlaub; Cindy L Will; Marc Gentzel; Matthias Wilm; Reinhard Lührmann
A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing.
The EMBO journal 2004;23(12):2381-91.
2004: Cindy L Will; Claudia Schneider; Markus Hossbach; Henning Urlaub; Reinhard Rauhut; Sayda M Elbashir; Thomas Tuschl; Reinhard Lührmann
The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.
RNA (New York, N.Y.) 2004;10(6):929-41.
2003: Monika M Golas; Bjoern Sander; Cindy L Will; Reinhard Lührmann; Holger Stark
Molecular architecture of the multiprotein splicing factor SF3b.
Science (New York, N.Y.) 2003;300(5621):980-4.
2002: Klaus Hartmuth; Henning Urlaub; Hans-Peter Vornlocher; Cindy L Will; Marc Gentzel; Matthias Wilm; Reinhard Lührmann
Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16719-24.
2002: Evgeny M Makarov; Olga V Makarova; Henning Urlaub; Marc Gentzel; Cindy L Will; Matthias Wilm; Reinhard Lührmann
Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome.
Science (New York, N.Y.) 2002;298(5601):2205-8.
2002: Cindy L Will; Henning Urlaub; Tilmann Achsel; Marc Gentzel; Matthias Wilm; Reinhard Lührmann
Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.
The EMBO journal 2002;21(18):4978-88.
2002: Claudia Schneider; Cindy L Will; Olga V Makarova; Evgeny M Makarov; Reinhard Lührmann
Human U4/U6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions.
Molecular and cellular biology 2002;22(10):3219-29.
2001: Cindy L Will; Claudia Schneider; A M MacMillan; N F Katopodis; G Neubauer; Matthias Wilm; Reinhard Lührmann; Charles C Query
A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site.
The EMBO journal 2001;20(16):4536-46.
2001: Cindy L Will; Reinhard Lührmann
Spliceosomal UsnRNP biogenesis, structure and function.
Current opinion in cell biology 2001;13(3):290-301.
2001: Cindy L Will; Reinhard Lührmann
Molecular biology. RNP remodeling with DExH/D boxes.
Science (New York, N.Y.) 2001;291(5510):1916-7.
1999: Cindy L Will; C Schneider; R Reed; Reinhard Lührmann
Identification of both shared and distinct proteins in the major and minor spliceosomes.
Science (New York, N.Y.) 1999;284(5422):2003-5.
1997: S Teigelkamp; C Mundt; Tilmann Achsel; Cindy L Will; Reinhard Lührmann
The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p.
RNA (New York, N.Y.) 1997;3(11):1313-26.
1997: Jörg Lauber; G Plessel; S Prehn; Cindy L Will; Patrizia Fabrizio; K Gröning; William Stratton Lane; Reinhard Lührmann
The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p.
RNA (New York, N.Y.) 1997;3(8):926-41.
1997: Cindy L Will; Reinhard Lührmann
Protein functions in pre-mRNA splicing.
Current opinion in cell biology 1997;9(3):320-8.
1997: S Fetzer; Jörg Lauber; Cindy L Will; Reinhard Lührmann
The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase.
RNA (New York, N.Y.) 1997;3(4):344-55.
1996: Cindy L Will; S Rümpler; J Klein Gunnewiek; W J van Venrooij; Reinhard Lührmann
In vitro reconstitution of mammalian U1 snRNPs active in splicing: the U1-C protein enhances the formation of early (E) spliceosomal complexes.
Nucleic acids research 1996;24(23):4614-23.
1995: S F Jamison; Z Pasman; J Wang; Cindy L Will; Reinhard Lührmann; James L Manley; Mariano A Garcia-Blanco
U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements.
Nucleic acids research 1995;23(16):3260-7.
1995: V Ségault; Cindy L Will; B S Sproat; Reinhard Lührmann
In vitro reconstitution of mammalian U2 and U5 snRNPs active in splicing: Sm proteins are functionally interchangeable and are essential for the formation of functional U2 and U5 snRNPs.
The EMBO journal 1995;14(16):4010-21.
1994: J D Kohtz; S F Jamison; Cindy L Will; P Zuo; Reinhard Lührmann; Mariano A Garcia-Blanco; James L Manley
Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors.
Nature 1994;368(6467):119-24.
1993: Cindy L Will; S E Behrens; Reinhard Lührmann
Protein composition of mammalian spliceosomal snRNPs.
Molecular biology reports 1993;18(2):121-6.
1993: A Woppmann; Cindy L Will; U Kornstädt; P Zuo; James L Manley; Reinhard Lührmann
Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors.
Nucleic acids research 1993;21(12):2815-22.
1993: Cindy L Will; Elke Mühlberger; D Linder; Werner Slenczka; Hans-Dieter Klenk; Heinz Feldmann
Marburg virus gene 4 encodes the virion membrane protein, a type I transmembrane glycoprotein.
Journal of virology 1993;67(3):1203-10.
1992: Heinz Feldmann; Elke Mühlberger; A Randolf; Cindy L Will; M P Kiley; A Sanchez; Hans-Dieter Klenk
Marburg virus, a filovirus: messenger RNAs, gene order, and regulatory elements of the replication cycle.
Virus research 1992;24(1):1-19.
1992: Elke Mühlberger; A Sanchez; A Randolf; Cindy L Will; M P Kiley; Hans-Dieter Klenk; Heinz Feldmann
The nucleotide sequence of the L gene of Marburg virus, a filovirus: homologies with paramyxoviruses and rhabdoviruses.
Virology 1992;187(2):534-47.
1992: Wolfgang Garten; Cindy L Will; K Buckard; K Kuroda; D Ortmann; K Munk; C Scholtissek; Hans-Joachim Schnittler; Detlev Drenckhahn; Hans-Dieter Klenk
Structure and assembly of hemagglutinin mutants of fowl plague virus with impaired surface transport.
Journal of virology 1992;66(3):1495-505.
1992: S Becker; Heinz Feldmann; Cindy L Will; Werner Slenczka
Evidence for occurrence of filovirus antibodies in humans and imported monkeys: do subclinical filovirus infections occur worldwide?
Medical microbiology and immunology 1992;181(1):43-55.
1991: Heinz Feldmann; Cindy L Will; M Schikore; Werner Slenczka; Hans-Dieter Klenk
Glycosylation and oligomerization of the spike protein of Marburg virus.
Virology 1991;182(1):353-6.
1986: W Schuy; Cindy L Will; K Kuroda; C Scholtissek; Wolfgang Garten; Hans-Dieter Klenk
Mutations blocking the transport of the influenza virus hemagglutinin between the rough endoplasmic reticulum and the Golgi apparatus.
The EMBO journal 1986;5(11):2831-6.