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Hans Will

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P Wimmer; Peter Groitl; S Schreiner; Hans Will; J Berscheminski; Paola Blanchette; Philip E Branton; W Ching; Thomas Dobner
Cross-talk between phosphorylation and SUMOylation regulates transforming activities of an adenoviral oncoprotein.
Andreas Mund; Kerstin Reumann; Tobias Schubert; Evi Soutoglou; Hannah Staege; SLIMANE AIT-SI-ALI; Valentine Battisti; Lauriane Fritsch; Anne-Sophie Hoffbeck; Sarah Kinkley; Malte Kriegs; Hans Will
SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response.
Kathrein von Kopylow; Hans Will; Wolfgang Schulze; Hannah Staege; Christiane Kirchhoff
Fibroblast growth factor receptor 3 is highly expressed in rarely dividing human type A spermatogonia.

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2013: P Wimmer; Peter Groitl; S Schreiner; Hans Will; J Berscheminski; Paola Blanchette; Philip E Branton; W Ching; Thomas Dobner
Cross-talk between phosphorylation and SUMOylation regulates transforming activities of an adenoviral oncoprotein.
Oncogene 2013;32(13):1626-37.
2012: Andreas Mund; Kerstin Reumann; Tobias Schubert; Evi Soutoglou; Hannah Staege; SLIMANE AIT-SI-ALI; Valentine Battisti; Lauriane Fritsch; Anne-Sophie Hoffbeck; Sarah Kinkley; Malte Kriegs; Hans Will
SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response.
Nucleic acids research 2012;40(22):11363-79.
2012: Kathrein von Kopylow; Hans Will; Wolfgang Schulze; Hannah Staege; Christiane Kirchhoff
Fibroblast growth factor receptor 3 is highly expressed in rarely dividing human type A spermatogonia.
Histochemistry and cell biology 2012;138(5):759-72.
2009: Sarah Kinkley; Hannah Staege; Gerrit Mohrmann; Gabor Rohaly; Theres Schaub; Elisabeth Kremmer; Andreas Winterpacht; Hans Will
SPOC1: a novel PHD-containing protein modulating chromatin structure and mitotic chromosome condensation.
Journal of cell science 2009;122(Pt 16):2946-56.
2007: Mouna Mhamdi; Anneke Funk; Heinz Hohenberg; Hans Will; Hüseyin Sirma
Assembly and budding of a hepatitis B virus is mediated by a novel type of intracellular vesicles.
Hepatology (Baltimore, Md.) 2007;46(1):95-106.
2007: Eckart Matthes; A Funk; I Krahn; K Gaertner; MJ von Janta-Lipinski; Li Lin; Hans Will; Hüseyin Sirma
Strong and selective inhibitors of hepatitis B virus replication among novel N4-hydroxy- and 5-methyl-beta-L-deoxycytidine analogues.
Antimicrobial agents and chemotherapy 2007;51(7):2523-30.
2007: Kristijana Milovic-Holm; Eva Krieghoff; Kirsten Jensen; Hans Will; Thomas G Hofmann
FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies.
The EMBO journal 2007;26(2):391-401.
2007: Anneke Funk; Mouna Mhamdi; Hans Will; Hüseyin Sirma
Avian hepatitis B viruses: molecular and cellular biology, phylogenesis, and host tropism.
World journal of gastroenterology : WJG 2007;13(1):91-103.
2006: Anneke Funk; Mouna Mhamdi; Heinz Hohenberg; Hans Will; Hüseyin Sirma
pH-independent entry and sequential endosomal sorting are major determinants of hepadnaviral infection in primary hepatocytes.
Hepatology (Baltimore, Md.) 2006;44(3):685-93.
2006: Oliver Schildgen; Hüseyin Sirma; Anneke Funk; Cynthia Olotu; Ulrike C Wend; Heinz Hartmann; Martin Helm; Jürgen K Rockstroh; Wulf R Willems; Hans Will; Wolfram H Gerlich
Variant of hepatitis B virus with primary resistance to adefovir.
The New England journal of medicine 2006;354(17):1807-12.
2006: Lars Stoeckl; Anneke Funk; Ariane Kopitzki; Boerries Brandenburg; Stefanie Oess; Hans Will; Hüseyin Sirma; Eberhard Hildt
Identification of a structural motif crucial for infectivity of hepatitis B viruses.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(17):6730-4.
2006: Sandra Fleischer; Stefan Wiemann; Hans Will; Thomas G Hofmann
PML-associated repressor of transcription (PAROT), a novel KRAB-zinc finger repressor, is regulated through association with PML nuclear bodies.
Experimental cell research 2006;312(6):901-12.
2006: Tilman Heise; Gunhild Sommer; Kerstin Reumann; Imke Meyer; Hans Will; Heiner Schaal
The hepatitis B virus PRE contains a splicing regulatory element.
Nucleic acids research 2006;34(1):353-63.
2005: Beate Friedrich; Madlen Wollersheim; Boerries Brandenburg; Ramona Foerste; Hans Will; Eberhard Hildt
Induction of anti-proliferative mechanisms in hepatitis B virus producing cells.
Journal of hepatology 2005;43(4):696-703.
2005: Thomas G Hofmann; Ellis Jaffray; Nicole Stollberg; Ron Thomas Hay; Hans Will
Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification.
The Journal of biological chemistry 2005;280(32):29224-32.
2005: Li Lin; Alexej Prassolov; Anneke Funk; Laura Quinn; Heinz Hohenberg; Kai Frölich; John Newbold; Arne Ludwig; Hans Will; Hüseyin Sirma; Falko Steinbach
Evidence from nature: interspecies spread of heron hepatitis B viruses.
The Journal of general virology 2005;86(Pt 5):1335-42.
2005: Caroline Janka; Carlo Selmi; M Eric Gershwin; Hans Will; Thomas Sternsdorf
Small ubiquitin-related modifiers: A novel and independent class of autoantigens in primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 2005;41(3):609-16.
2004: Shau-Feng Chang; Shih-Hsuan Chang; Bi-Chen Li; Hans Will; Hans Jürgen Netter
Characterization of nonconventional hepatitis B viruses lacking the core promoter.
Virology 2004;330(2):437-46.
2004: Imke Ehlers; Sven Horke; Kerstin Reumann; Andreas Rang; Frank Grosse; Hans Will; Tilman Heise
Functional characterization of the interaction between human La and hepatitis B virus RNA.
The Journal of biological chemistry 2004;279(42):43437-47.
2004: Anneke Funk; Mouna Mhamdi; Li Lin; Hans Will; Hüseyin Sirma
Itinerary of hepatitis B viruses: delineation of restriction points critical for infectious entry.
Journal of virology 2004;78(15):8289-300.
2004: Sven Horke; Kerstin Reumann; Michaela Schweizer; Hans Will; Tilman Heise
Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA.
The Journal of biological chemistry 2004;279(25):26563-70.
2004: Anneke Funk; Heinz Hohenberg; Mouna Mhamdi; Hans Will; Hüseyin Sirma
Spread of hepatitis B viruses in vitro requires extracellular progeny and may be codetermined by polarized egress.
Journal of virology 2004;78(8):3977-83.
2003: Thomas G Hofmann; Nicole Stollberg; M Lienhard Schmitz; Hans Will
HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells.
Cancer research 2003;63(23):8271-7.
2003: Thomas G Hofmann; Hans Will
Body language: the function of PML nuclear bodies in apoptosis regulation.
Cell death and differentiation 2003;10(12):1290-9.
2003: Andreas Möller; Hüseyin Sirma; Thomas G Hofmann; Hannah Staege; Ekaterina Gresko; Katharina Schmid Lüdi; Elisabeth Klimczak; Wulf Dröge; Hans Will; M Lienhard Schmitz
Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression.
Oncogene 2003;22(54):8731-7.
2003: Tatyana Kalinina; Alicja Iwanski; Hans Will; Martina Sterneck
Deficiency in virion secretion and decreased stability of the hepatitis B virus immune escape mutant G145R.
Hepatology (Baltimore, Md.) 2003;38(5):1274-81.
2003: Tatyana Kalinina; Anna Riu; Lutz Fischer; Teresa Santantonio; Hans Will; Martina Sterneck
Selection of a secretion-incompetent mutant in the serum of a patient with severe hepatitis B.
Gastroenterology 2003;125(4):1077-84.
2003: Andreas Möller; Hüseyin Sirma; Thomas G Hofmann; Sven Rueffer; Elisabeth Klimczak; Wulf Dröge; Hans Will; M Lienhard Schmitz
PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains.
Cancer research 2003;63(15):4310-4.
2003: Monica Gostissa; Thomas G Hofmann; Hans Will; Giannino Del Sal
Regulation of p53 functions: let's meet at the nuclear bodies.
Current opinion in cell biology 2003;15(3):351-7.
2003: Alexej Prassolov; Heinz Hohenberg; Tatyana Kalinina; Carola Schneider; Lucyna Cova; Oliver Krone; Kai Frölich; Hans Will; Hüseyin Sirma
New hepatitis B virus of cranes that has an unexpected broad host range.
Journal of virology 2003;77(3):1964-76.
2002: Janina Görnemann; Thomas G Hofmann; Hans Will; Martin Müller
Interaction of human papillomavirus type 16 L2 with cellular proteins: identification of novel nuclear body-associated proteins.
Virology 2002;303(1):69-78.
2002: Andreas Rang; Michael Bruns; Tilman Heise; Hans Will
Antiviral activity of interferon-alpha against hepatitis B virus can be studied in non-hepatic cells and Is independent of MxA.
The Journal of biological chemistry 2002;277(10):7645-7.
2002: Maura Dandri; Martin R Burda; Alexander Bürkle; David M Zuckerman; Hans Will; Charles E Rogler; Heiner Greten; Jörg Petersen
Increase in de novo HBV DNA integrations in response to oxidative DNA damage or inhibition of poly(ADP-ribosyl)ation.
Hepatology (Baltimore, Md.) 2002;35(1):217-23.
2002: Thomas G Hofmann; Andreas Möller; Hüseyin Sirma; Hanswalter Zentgraf; Yoichi Taya; Wulf Dröge; Hans Will; M Lienhard Schmitz
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2.
Nature cell biology 2002;4(1):1-10.
2001: Lutz Fischer; Tatyana Kalinina; Xavier Rogiers; Hans Will; Martina Sterneck
GLY145ARG mutation emerging under HBIG treatment in patients with recurrent HBV after liver transplantation strongly reduces viral secretion.
Transplantation proceedings 2001;33(7-8):3633-6.
2001: Martin R Burda; Stephan Günther; Maura Dandri; Hans Will; Jörg Petersen
Structural and functional heterogeneity of naturally occurring hepatitis B virus variants.
Antiviral research 2001;52(2):125-38.
2001: I Pult; Hans Jürgen Netter; Michael Bruns; Alexej Prassolov; Hüseyin Sirma; Heinz Hohenberg; Shau-Feng Chang; Kai Frölich; Oliver Krone; E F Kaleta; Hans Will
Identification and analysis of a new hepadnavirus in white storks.
Virology 2001;289(1):114-28.
2001: Maura Dandri; Martin R Burda; Andreas Gocht; Eva Török; Jörg-Matthias Pollok; Charles E Rogler; Hans Will; Jörg Petersen
Woodchuck hepatocytes remain permissive for hepadnavirus infection and mouse liver repopulation after cryopreservation.
Hepatology (Baltimore, Md.) 2001;34(4 Pt 1):824-33.
2001: Tatyana Kalinina; A Riu; Lutz Fischer; Hans Will; Martina Sterneck
A dominant hepatitis B virus population defective in virus secretion because of several S-gene mutations from a patient with fulminant hepatitis.
Hepatology (Baltimore, Md.) 2001;34(2):385-94.
2001: Maura Dandri; Martin R Burda; Eva Török; Jörg-Matthias Pollok; A Iwanska; Gunhild Sommer; X Rogiers; Charles E Rogler; Sanjeev Gupta; Hans Will; Heiner Greten; Jörg Petersen
Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus.
Hepatology (Baltimore, Md.) 2001;33(4):981-8.
2001: Andreas Rang; Tilman Heise; Hans Will
Lack of a role of the interferon-stimulated response element-like region in interferon alpha -induced suppression of Hepatitis B virus in vitro.
The Journal of biological chemistry 2001;276(5):3531-5.
2001: Shau-Feng Chang; Hans Jürgen Netter; Eberhard Hildt; R Schuster; S Schaefer; Y C Hsu; Andreas Rang; Hans Will
Duck hepatitis B virus expresses a regulatory HBx-like protein from a hidden open reading frame.
Journal of virology 2001;75(1):161-70.
2000: V Fogal; Monica Gostissa; Peter Sandy; Paola Zacchi; Thomas Sternsdorf; Kirsten Jensen; P P Pandolfi; Hans Will; Claudio Schneider; Giannino Del Sal
Regulation of p53 activity in nuclear bodies by a specific PML isoform.
The EMBO journal 2000;19(22):6185-95.
2000: Stephan Günther; N Piwon; A Jung; A Iwanska; Herbert Schmitz; Hans Will
Enhanced replication contributes to enrichment of hepatitis B virus with a deletion in the core gene.
Virology 2000;273(2):286-99.
2000: Maura Dandri; Martin R Burda; Hans Will; Jörg Petersen
Increased hepatocyte turnover and inhibition of woodchuck hepatitis B virus replication by adefovir in vitro do not lead to reduction of the closed circular DNA.
Hepatology (Baltimore, Md.) 2000;32(1):139-46.
2000: Gunhild Sommer; Florian van Bommel; Hans Will
Genotype-specific synthesis and secretion of spliced hepatitis B virus genomes in hepatoma cells.
Virology 2000;271(2):371-81.
2000: Jukka Pitkänen; Vassilis Doucas; Thomas Sternsdorf; T Nakajima; S Aratani; Kirsten Jensen; Hans Will; Perttu Vähämurto; Juha Ollila; Mauno Vihinen; Hamish Scott; Stylianos E Antonarakis; Jun Kudoh; Nobuyoshi Shimizu; Kai Krohn; Pärt Peterson
The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein.
The Journal of biological chemistry 2000;275(22):16802-9.
2000: Andreas Rang; Hans Will
The tetracycline-responsive promoter contains functional interferon-inducible response elements.
Nucleic acids research 2000;28(5):1120-5.
1999: Andreas Rang; Stephan Günther; Hans Will
Effect of interferon alpha on hepatitis B virus replication and gene expression in transiently transfected human hepatoma cells.
Journal of hepatology 1999;31(5):791-9.
1999: Shau-Feng Chang; Hans Jürgen Netter; Michael Bruns; R Schneider; Kai Frölich; Hans Will
A new avian hepadnavirus infecting snow geese (Anser caerulescens) produces a significant fraction of virions containing single-stranded DNA.
Virology 1999;262(1):39-54.
1999: E Kirschning; K Jensen; S Dübel; G Rutter; Heinz Hohenberg; Hans Will
Primary structure of the antigen-binding domains of a human oligodendrocyte-reactive IgM monoclonal antibody derived from a patient with multiple sclerosis.
Journal of neuroimmunology 1999;99(1):122-30.
1999: Thomas Sternsdorf; Elena Puccetti; Kirsten Jensen; Dieter Hoelzer; Hans Will; Oliver G Ottmann; Martin Ruthardt
PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia.
Molecular and cellular biology 1999;19(7):5170-8.
1999: Teresa Santantonio; S Gunther; Martina Sterneck; Maria Rendina; Michel Messner; Bernard Launois; Antonio Francavilla; G Pastore; Hans Will
Liver graft infection by HBV S-gene mutants in transplant patients receiving long-term HBIg prophylaxis.
Hepato-gastroenterology 1999;46(27):1848-54.
1999: Stephan Günther; F von Breunig; Teresa Santantonio; Maria-Christina Jung; Giovanni B Gaeta; L Fischer; Martina Sterneck; Hans Will
Absence of mutations in the YMDD motif/B region of the hepatitis B virus polymerase in famciclovir therapy failure.
Journal of hepatology 1999;30(5):749-54.
1999: Thomas Sternsdorf; Kirsten Jensen; B Reich; Hans Will
The nuclear dot protein sp100, characterization of domains necessary for dimerization, subcellular localization, and modification by small ubiquitin-like modifiers.
The Journal of biological chemistry 1999;274(18):12555-66.
1999: C Sunyach; Christine Rollier; Magdalena Robaczewska; Christelle Borel; Luc Barraud; Alan Campbell Kay; Christian Trépo; Hans Will; Lucyna Cova
Residues critical for duck hepatitis B virus neutralization are involved in host cell interaction.
Journal of virology 1999;73(4):2569-75.
1999: H H Guldner; C Szostecki; P Schröder; U Matschl; Kirsten Jensen; C Lüders; Hans Will; Thomas Sternsdorf
Splice variants of the nuclear dot-associated Sp100 protein contain homologies to HMG-1 and a human nuclear phosphoprotein-box motif.
Journal of cell science 1999;112 ( Pt 5)():733-47.
1999: Stephan Günther; L Fischer; I Pult; Martina Sterneck; Hans Will
Naturally occurring variants of hepatitis B virus.
Advances in virus research 1999;52():25-137.
1998: S F Chang; B Reich; J D Brunzell; Hans Will
Detailed characterization of the binding site of the lipoprotein lipase-specific monoclonal antibody 5D2.
Journal of lipid research 1998;39(12):2350-9.
1998: Martina Sterneck; Tatyana Kalinina; Stephan Günther; Lutz Fischer; Teresa Santantonio; Heiner Greten; Hans Will
Functional analysis of HBV genomes from patients with fulminant hepatitis.
Hepatology (Baltimore, Md.) 1998;28(5):1390-7.
1998: M Altfeld; Jürgen K Rockstroh; Marylyn M Addo; Bernd Kupfer; I Pult; Hans Will; Ulrich Spengler
Reactivation of hepatitis B in a long-term anti-HBs-positive patient with AIDS following lamivudine withdrawal.
Journal of hepatology 1998;29(2):306-9.
1998: Stephan Günther; W Paulij; H Meisel; Hans Will
Analysis of hepatitis B virus populations in an interferon-alpha-treated patient reveals predominant mutations in the C-gene and changing e-antigenicity.
Virology 1998;244(1):146-60.
1998: Stephan Günther; N Piwon; Hans Will
Wild-type levels of pregenomic RNA and replication but reduced pre-C RNA and e-antigen synthesis of hepatitis B virus with C(1653) --> T, A(1762) --> T and G(1764) --> A mutations in the core promoter.
The Journal of general virology 1998;79 ( Pt 2)():375-80.
1998: Stephan Günther; Gunhild Sommer; F Von Breunig; A Iwanska; Tatyana Kalinina; Martina Sterneck; Hans Will
Amplification of full-length hepatitis B virus genomes from samples from patients with low levels of viremia: frequency and functional consequences of PCR-introduced mutations.
Journal of clinical microbiology 1998;36(2):531-8.
1998: Michael Bruns; S Miska; S Chassot; Hans Will
Enhancement of hepatitis B virus infection by noninfectious subviral particles.
Journal of virology 1998;72(2):1462-8.
1997: Thomas Sternsdorf; Kirsten Jensen; Hans Will
Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1.
The Journal of cell biology 1997;139(7):1621-34.
1997: Gunhild Sommer; Stephan Günther; Martina Sterneck; S Otto; Hans Will
A new class of defective hepatitis B virus genomes with an internal poly(dA) sequence.
Virology 1997;239(2):402-12.
1997: Thomas Sternsdorf; T Grötzinger; Kirsten Jensen; Hans Will
Nuclear dots: actors on many stages.
Immunobiology 1997;198(1-3):307-31.
1997: Stephan Günther; Gunhild Sommer; A Iwanska; Hans Will
Heterogeneity and common features of defective hepatitis B virus genomes derived from spliced pregenomic RNA.
Virology 1997;238(2):363-71.
1997: D Züchner; Thomas Sternsdorf; C Szostecki; E Jenny Heathcote; Karen Cauch-Dudek; Hans Will
Prevalence, kinetics, and therapeutic modulation of autoantibodies against Sp100 and promyelocytic leukemia protein in a large cohort of patients with primary biliary cirrhosis.
Hepatology (Baltimore, Md.) 1997;26(5):1123-30.
1997: Stephan Günther; Gunhild Sommer; U Plikat; A Iwanska; Simon Wain-Hobson; Hans Will; Andreas Meyerhans
Naturally occurring hepatitis B virus genomes bearing the hallmarks of retroviral G-->A hypermutation.
Virology 1997;235(1):104-8.
1997: Thomas Sternsdorf; Kirsten Jensen; D Züchner; Hans Will
Cellular localization, expression, and structure of the nuclear dot protein 52.
The Journal of cell biology 1997;138(2):435-48.
1997: S F Chang; J G Scharf; Hans Will
Structural and functional analysis of the promoter of the hepatic lipase gene.
European journal of biochemistry / FEBS 1997;247(1):148-59.
1997: Hans Jürgen Netter; S Chassot; Shau-Feng Chang; Lucyna Cova; Hans Will
Sequence heterogeneity of heron hepatitis B virus genomes determined by full-length DNA amplification and direct sequencing reveals novel and unique features.
The Journal of general virology 1997;78 ( Pt 7)():1707-18.
1997: Martina Sterneck; Stephan Günther; J Gerlach; Nikolai Naoumov; Teresa Santantonio; L Fischer; X Rogiers; Heiner Greten; R Williams; Hans Will
Hepatitis B virus sequence changes evolving in liver transplant recipients with fulminant hepatitis.
Journal of hepatology 1997;26(4):754-64.
1997: C Szostecki; H H Guldner; Hans Will
Autoantibodies against "nuclear dots" in primary biliary cirrhosis.
Seminars in liver disease 1997;17(1):71-8.
1997: Teresa Santantonio; Maria-Christina Jung; G Pastore; G Angarano; Stephan Günther; Hans Will
Familial clustering of HBV pre-C and pre-S mutants.
Journal of hepatology 1997;26(2):221-7.
1996: Stephan Günther; N Piwon; A Iwanska; R Schilling; Helga Meisel; Hans Will
Type, prevalence, and significance of core promoter/enhancer II mutations in hepatitis B viruses from immunosuppressed patients with severe liver disease.
Journal of virology 1996;70(12):8318-31.
1996: T Grötzinger; Kirsten Jensen; Hans Will
The interferon (IFN)-stimulated gene Sp100 promoter contains an IFN-gamma activation site and an imperfect IFN-stimulated response element which mediate type I IFN inducibility.
The Journal of biological chemistry 1996;271(41):25253-60.
1996: Martina Sterneck; Stephan Günther; Teresa Santantonio; Lutz Fischer; C E Broelsch; Heiner Greten; Hans Will
Hepatitis B virus genomes of patients with fulminant hepatitis do not share a specific mutation.
Hepatology (Baltimore, Md.) 1996;24(2):300-6.
1996: G Marinos; Francesco Torre; Stephan Günther; Mark Thomas; Hans Will; Roger Williams; Nikolai Naoumov
Hepatitis B virus variants with core gene deletions in the evolution of chronic hepatitis B infection.
Gastroenterology 1996;111(1):183-92.
1996: T Grötzinger; Thomas Sternsdorf; Kirsten Jensen; Hans Will
Interferon-modulated expression of genes encoding the nuclear-dot-associated proteins Sp100 and promyelocytic leukemia protein (PML).
European journal of biochemistry / FEBS 1996;238(2):554-60.
1996: T Grötzinger; Kirsten Jensen; H H Guldner; Thomas Sternsdorf; C Szostecki; M Schwab; L Savelyeva; B Reich; Hans Will
A highly amplified mouse gene is homologous to the human interferon-responsive Sp100 gene encoding an autoantigen associated with nuclear dots.
Molecular and cellular biology 1996;16(3):1150-6.
1995: Stephan Günther; B C Li; S Miska; Detlev H Krüger; Helga Meisel; Hans Will
A novel method for efficient amplification of whole hepatitis B virus genomes permits rapid functional analysis and reveals deletion mutants in immunosuppressed patients.
Journal of virology 1995;69(9):5437-44.
1995: Thomas Sternsdorf; H H Guldner; C Szostecki; T Grötzinger; Hans Will
Two nuclear dot-associated proteins, PML and Sp100, are often co-autoimmunogenic in patients with primary biliary cirrhosis.
Scandinavian journal of immunology 1995;42(2):257-68.
1995: Ulrike Beisiegel; D Ameis; Hans Will; Heiner Greten
[Hypertriglyceridemia and arteriosclerosis. Physiology and pathophysiology of chylomicron catabolism].
Der Internist 1995;36(4):357-61.
1995: Stephan Günther; S Miska; Helga Meisel; Hans Will
Structure and selection of hepatitis B virus variants during the natural course of infection and interferon therapy.
Princess Takamatsu symposia 1995;25():211-20.
1994: C Szostecki; Hans Will; H H Guldner
[Humoral autoimmune response to nuclear Sp100 autoantigen in patients with primary biliary cirrhosis].
Zeitschrift für ärztliche Fortbildung 1994;88(7-8):573-8.
1993: D Fernholz; G Wildner; Hans Will
Minor envelope proteins of duck hepatitis B virus are initiated at internal pre-S AUG codons but are not essential for infectivity.
Virology 1993;197(1):64-73.
1993: D Fernholz; Peter Galle; M Stemler; M Brunetto; Ferruccio Bonino; Hans Will
Infectious hepatitis B virus variant defective in pre-S2 protein expression in a chronic carrier.
Virology 1993;194(1):137-48.
1993: S Miska; Stephan Günther; Milen Vassilev; Helga Meisel; Gerd R Pape; Hans Will
Heterogeneity of hepatitis B virus C-gene sequences: implications for amplification and sequencing.
Journal of hepatology 1993;18(1):53-61.
1993: Teresa Santantonio; Maria-Christina Jung; Laura Monno; M Milella; T Iacovazzi; Giuseppe Pastore; Hans Will
Prevalence of wildtype and pre-C HBV variants in HBsAg/anti-HBe positive carriers with chronic hepatitis delta virus infection.
Progress in clinical and biological research 1993;382():235-42.
1993: Florian Schodel; G Neckermann; D Peterson; K Fuchs; S Fuller; Hans Will; M Roggendorf
Immunization with recombinant woodchuck hepatitis virus nucleocapsid antigen or hepatitis B virus nucleocapsid antigen protects woodchucks from woodchuck hepatitis virus infection.
Vaccine 1993;11(6):624-8.
1993: Teresa Santantonio; Maria-Christina Jung; Laura Monno; M Milella; T Iacovazzi; Gerd R Pape; Giuseppe Pastore; Hans Will
Long-term response to interferon therapy in chronic hepatitis B: importance of hepatitis B virus heterogeneity.
Archives of virology. Supplementum 1993;8():171-8.
1993: S Miska; Hans Will
Hepatitis B virus C-gene variants.
Archives of virology. Supplementum 1993;8():155-69.
1992: H H Guldner; C Szostecki; T Grötzinger; Hans Will
IFN enhance expression of Sp100, an autoantigen in primary biliary cirrhosis.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(12):4067-73.
1992: C Szostecki; Hans Will; Hans Jürgen Netter; H H Guldner
Autoantibodies to the nuclear Sp100 protein in primary biliary cirrhosis and associated diseases: epitope specificity and immunoglobulin class distribution.
Scandinavian journal of immunology 1992;36(4):555-64.
1992: Teresa Santantonio; Maria-Christina Jung; R Schneider; D Fernholz; M Milella; L Monno; Giuseppe Pastore; Gerd R Pape; Hans Will
Hepatitis B virus genomes that cannot synthesize pre-S2 proteins occur frequently and as dominant virus populations in chronic carriers in Italy.
Virology 1992;188(2):948-52.
1992: T Grötzinger; Hans Will
Sensitive method for identification of minor hepatitis B mutant viruses.
Virology 1992;187(1):383-7.
1992: Stephan Günther; Helga Meisel; A Reip; S Miska; Detlev H Krüger; Hans Will
Frequent and rapid emergence of mutated pre-C sequences in HBV from e-antigen positive carriers who seroconvert to anti-HBe during interferon treatment.
Virology 1992;187(1):271-9.
1992: Nikolai Naoumov; R Schneider; T Grötzinger; Maria-Christina Jung; S Miska; Gerd R Pape; Hans Will
Precore mutant hepatitis B virus infection and liver disease.
Gastroenterology 1992;102(2):538-43.
1992: Florian Schodel; A M Moriarty; Darrell L Peterson; J A Zheng; J L Hughes; Hans Will; D J Leturcq; J S McGee; David R Milich
The position of heterologous epitopes inserted in hepatitis B virus core particles determines their immunogenicity.
Journal of virology 1992;66(1):106-14.
1991: G Wildner; D Fernholz; R Sprengel; R Schneider; Hans Will
Characterization of infectious and defective cloned avian hepadnavirus genomes.
Virology 1991;185(1):345-53.
1991: R Schneider; Hans Will
Regulatory sequences of duck hepatitis B virus C gene transcription.
Journal of virology 1991;65(11):5693-701.
1991: Teresa Santantonio; Maria-Christina Jung; R Schneider; Giuseppe Pastore; Gerd R Pape; Hans Will
Selection for a pre-C stop codon mutation in a hepatitis B virus variant with a pre-C initiation codon mutation during interferon treatment.
Journal of hepatology 1991;13(3):368-71.
1991: S F Chang; Hans Jürgen Netter; Hans Will
Characterization of cDNA encoding the mouse hepatic triglyceride lipase and expression by in vitro translation.
FEBS letters 1991;289(1):69-72.
1991: R Sprengel; R Schneider; P L Marion; D Fernholz; G Wildner; Hans Will
Comparative sequence analysis of defective and infectious avian hepadnaviruses.
Nucleic acids research 1991;19(15):4289.
1991: Teresa Santantonio; Maria-Christina Jung; S Miska; Giuseppe Pastore; Gerd R Pape; Hans Will
Prevalence and type of pre-C HBV mutants in anti-HBe positive carriers with chronic liver disease in a highly endemic area.
Virology 1991;183(2):840-4.
1991: Hans Jürgen Netter; Hans Will; C Szostecki; H H Guldner
Repetitive P68-autoantigen specific epitopes recognized by human anti-(U1) small nuclear ribonucleoprotein autoantibodies.
Journal of autoimmunity 1991;4(4):651-63.
1991: R Schneider; D Fernholz; G Wildner; Hans Will
Mechanism, kinetics, and role of duck hepatitis B virus e-antigen expression in vivo.
Virology 1991;182(2):503-12.
1991: Florian Schodel; Hans Will; S Johansson; J Sanchez; J Holmgren
Synthesis in Vibrio cholerae and secretion of hepatitis B virus antigens fused to Escherichia coli heat-labile enterotoxin subunit B.
Gene 1991;99(2):255-9.
1991: G Stahnke; R C Davis; Mark H Doolittle; Howard Wong; Michael C Schotz; Hans Will
Effect of N-linked glycosylation on hepatic lipase activity.
Journal of lipid research 1991;32(3):477-84.
1991: Teresa Santantonio; Maria-Christina Jung; S Miska; Giuseppe Pastore; Gerd R Pape; Hans Will
High prevalence and heterogeneity of HBV preC mutants in anti-HBe-positive carriers with chronic liver disease in southern Italy.
Journal of hepatology 1991;13 Suppl 4():S78-81.
1991: Hans Will
HBcAg and HBeAg expression: how, where, why or why not?
Journal of hepatology 1991;13 Suppl 4():S66-7.
1991: Hans Will
The X-protein of hepatitis B virus. Facts and fiction.
Journal of hepatology 1991;13 Suppl 4():S56-7.
1991: D Fernholz; M Stemler; M Brunetto; Ferruccio Bonino; Hans Will
Replicating and virion secreting hepatitis B mutant virus unable to produce preS2 protein.
Journal of hepatology 1991;13 Suppl 4():S102-4.
1990: C Szostecki; H H Guldner; Hans Jürgen Netter; Hans Will
Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(12):4338-47.
1990: Florian Schodel; David R Milich; Hans Will
Hepatitis B virus nucleocapsid/pre-S2 fusion proteins expressed in attenuated Salmonella for oral vaccination.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(12):4317-21.
1990: Florian Schodel; G Enders; Maria-Christina Jung; Hans Will
Recognition of a hepatitis B virus nucleocapsid T-cell epitope expressed as a fusion protein with the subunit B of Escherichia coli heat labile enterotoxin in attenuated salmonellae.
Vaccine 1990;8(6):569-72.
1990: Giovanni Raimondo; M Stemler; R Schneider; G Wildner; G Squadrito; Hans Will
Latency and reactivation of a precore mutant hepatitis B virus in a chronically infected patient.
Journal of hepatology 1990;11(3):374-80.
1990: Giovanni Raimondo; R Schneider; M Stemler; V Smedile; G Rodino; Hans Will
A new hepatitis B virus variant in a chronic carrier with multiple episodes of viral reactivation and acute hepatitis.
Virology 1990;179(1):64-8.
1990: T Weimer; Florian Schodel; Maria-Christina Jung; Gerd R Pape; A Alberti; G Fattovich; H Beljaars; P M van Eerd; Hans Will
Antibodies to the RNase H domain of hepatitis B virus P protein are associated with ongoing viral replication.
Journal of virology 1990;64(11):5665-8.
1990: Florian Schodel; Hans Will
Expression of hepatitis B virus antigens in attenuated Salmonellae for oral immunization.
Research in microbiology 1990;141(7-8):831-7.
1990: Hans Jürgen Netter; H H Guldner; C Szostecki; Hans Will
Major autoantigenic sites of the (U1) small nuclear ribonucleoprotein-specific 68-kDa protein.
Scandinavian journal of immunology 1990;32(2):163-76.
1990: M Stemler; T Weimer; Z X Tu; D F Wan; Massimo Levrero; C Jung; Gerd R Pape; Hans Will
Mapping of B-cell epitopes of the human hepatitis B virus X protein.
Journal of virology 1990;64(6):2802-9.
1990: D Ameis; G Stahnke; Junji Kobayashi; J McLean; G Lee; M Büscher; Michael C Schotz; Hans Will
Isolation and characterization of the human hepatic lipase gene.
The Journal of biological chemistry 1990;265(12):6552-5.
1990: R C Davis; G Stahnke; Howard Wong; Mark H Doolittle; D Ameis; Hans Will; Michael C Schotz
Hepatic lipase: site-directed mutagenesis of a serine residue important for catalytic activity.
The Journal of biological chemistry 1990;265(11):6291-5.
1990: H H Guldner; Hans Jürgen Netter; C Szostecki; E Jaeger; Hans Will
Human anti-p68 autoantibodies recognize a common epitope of U1 RNA containing small nuclear ribonucleoprotein and influenza B virus.
The Journal of experimental medicine 1990;171(3):819-29.
1990: V Lambert; D Fernholz; R Sprengel; I Fourel; G Deléage; G Wildner; C Peyret; Christian Trépo; Lucyna Cova; Hans Will
Virus-neutralizing monoclonal antibody to a conserved epitope on the duck hepatitis B virus pre-S protein.
Journal of virology 1990;64(3):1290-7.
1989: T Weimer; K Weimer; Z X Tu; Maria-Christina Jung; Gerd R Pape; Hans Will
Immunogenicity of human hepatitis B virus P-gene derived proteins.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(11):3750-6.
1988: Florian Schodel; T Weimer; Hans Will; R Sprengel
Amino acid sequence similarity between retroviral and E. coli RNase H and hepadnaviral gene products.
AIDS research and human retroviruses 1988;4(6):ix-xi.
1988: R Sprengel; E F Kaleta; Hans Will
Isolation and characterization of a hepatitis B virus endemic in herons.
Journal of virology 1988;62(10):3832-9.
1988: H H Guldner; Hans Jürgen Netter; C Szostecki; HJ Lakomek; Hans Will
Epitope mapping with a recombinant human 68-kDa (U1) ribonucleoprotein antigen reveals heterogeneous autoantibody profiles in human autoimmune sera.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(2):469-75.
1988: Hans Jürgen Netter; H H Guldner; C Szostecki; HJ Lakomek; Hans Will
A recombinant autoantigen derived from the human (U1) small nuclear RNP-specific 68-kd protein. Expression in Escherichia coli and serodiagnostic application.
Arthritis and rheumatism 1988;31(5):616-22.
1988: M Stemler; J Hess; R Braun; Hans Will; C H Schröder
Serological evidence for expression of the polymerase gene of human hepatitis B virus in vivo.
The Journal of general virology 1988;69 ( Pt 3)():689-93.
1987: Hans Will; W Reiser; T Weimer; E Pfaff; M Büscher; R Sprengel; R Cattaneo; H Schaller
Replication strategy of human hepatitis B virus.
Journal of virology 1987;61(3):904-11.
1987: G Stahnke; R Sprengel; J Augustin; Hans Will
Human hepatic triglyceride lipase: cDNA cloning, amino acid sequence and expression in a cultured cell line.
Differentiation; research in biological diversity 1987;35(1):45-52.