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David Williams

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Living Beings

Anatomy

Chemicals & Drugs

Physiology

Procedures

Disorders

Fanconi Anemia

Devices

Gene Transfer Techniques

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Publications

TOP 3
Xu Haiming; Eleswarapu Satyam; Geiger Hartmut; Szczur Kathleen; Daria Deidre; Zheng Yi; Settleman Jeffrey; Srour Edward F; Williams David A; Filippi Marie-Dominique
Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
Singh Thiyam Ramsing; Bakker Sietske T; Agarwal Sheba; Jansen Michael; Grassman Elke; Godthelp Barbara C; Ali Abdullah Mahmood; Du Chang-hu; Rooimans Martin A; Fan Qiang; Wahengbam Kebola; Steltenpool Jurgen; Andreassen Paul R; Williams David A; Joenje Hans; de Winter Johan P; Meetei Amom Ruhikanta
Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M.
Cancelas Jose A; Williams David A
Rho GTPases in hematopoietic stem cell functions.

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All Publications

2009: Xu Haiming; Eleswarapu Satyam; Geiger Hartmut; Szczur Kathleen; Daria Deidre; Zheng Yi; Settleman Jeffrey; Srour Edward F; Williams David A; Filippi Marie-Dominique
Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
Blood 2009;114(17):3557-66.
2009: Singh Thiyam Ramsing; Bakker Sietske T; Agarwal Sheba; Jansen Michael; Grassman Elke; Godthelp Barbara C; Ali Abdullah Mahmood; Du Chang-hu; Rooimans Martin A; Fan Qiang; Wahengbam Kebola; Steltenpool Jurgen; Andreassen Paul R; Williams David A; Joenje Hans; de Winter Johan P; Meetei Amom Ruhikanta
Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M.
Blood 2009;114(1):174-80.
2009: Cancelas Jose A; Williams David A
Rho GTPases in hematopoietic stem cell functions.
Current opinion in hematology 2009;16(4):249-54.
2009: Ali Abdullah Mahmood; Kirby Michelle; Jansen Michael; Lach Francis P; Schulte Jennifer; Singh Thiyam Ramsing; Batish Sat D; Auerbach Arleen D; Williams David A; Meetei Amom Ruhikanta
Identification and characterization of mutations in FANCL gene: a second case of Fanconi anemia belonging to FA-L complementation group.
Human mutation 2009;30(7):E761-70.
2009: Hoskins E E; Morris T A; Higginbotham J M; Spardy N; Cha E; Kelly P; Williams D A; Wikenheiser-Brokamp K A; Duensing S; Wells S I
Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture.
Oncogene 2009;28(5):674-85.
2008: Guo Fukun; Cancelas Jose A; Hildeman David; Williams David A; Zheng Yi
Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development.
Blood 2008;112(5):1767-75.
2008: Zhang Xiaoling; Shang Xun; Guo Fukun; Murphy Kim; Kirby Michelle; Kelly Patrick; Reeves Lilith; Smith Franklin O; Williams David A; Zheng Yi; Pang Qishen
Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A.
Blood 2008;112(5):1683-6.
2008: Milsom Michael D; Jerabek-Willemsen Moran; Harris Chad E; Schambach Axel; Broun Emily; Bailey Jeff; Jansen Michael; Schleimer David; Nattamai Kalpana; Wilhelm Jamie; Watson Amanda; Geiger Hartmut; Margison Geoffrey P; Moritz Thomas; Baum Christopher; Thomale Jürgen; Williams David A
Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells.
Cancer research 2008;68(15):6171-80.
2008: Müller Lars U W; Milsom Michael D; Kim Mi-Ok; Schambach Axel; Schuesler Todd; Williams David A
Rapid lentiviral transduction preserves the engraftment potential of Fanca(-/-) hematopoietic stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(6):1154-60.
2008: Thomas E K; Cancelas J A; Zheng Y; Williams D A
Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2008;22(5):898-904.
2008: Williams David A; Zheng Yi; Cancelas Jose A
Rho GTPases and regulation of hematopoietic stem cell localization.
Methods in enzymology 2008;439():365-93.
2007: Williams David A
An international conversation on Stem Cell Gene Therapy. 4th Stem Cell Conference on Stem Cell Gene Therapy, Thessaloniki, Greece, 13-17 September 2007.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(12):2058-9.
2007: Yang Linda; Wang Lei; Kalfa Theodosia A; Cancelas Jose A; Shang Xun; Pushkaran Suvarnamala; Mo Jun; Williams David A; Zheng Yi
Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.
Blood 2007;110(12):3853-61.
2007: Thomas Emily K; Cancelas Jose A; Chae Hee-Don; Cox Adrienne D; Keller Patricia J; Perrotti Danilo; Neviani Paolo; Druker Brian J; Setchell Kenneth D R; Zheng Yi; Harris Chad E; Williams David A
Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.
Cancer cell 2007;12(5):467-78.
2007: Li June; Sejas Daniel P; Zhang Xiaoling; Qiu Yuhui; Nattamai Kalpana J; Rani Reena; Rathbun Keaney R; Geiger Hartmut; Williams David A; Bagby Grover C; Pang Qishen
TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells.
The Journal of clinical investigation 2007;117(11):3283-95.
2007: Akbar H; Kim J; Funk K; Cancelas J A; Shang X; Chen L; Johnson J F; Williams D A; Zheng Y
Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation.
Journal of thrombosis and haemostasis : JTH 2007;5(8):1747-55.
2007: Milsom Michael D; Williams David A
Live and let die: in vivo selection of gene-modified hematopoietic stem cells via MGMT-mediated chemoprotection.
DNA repair 2007;6(8):1210-21.
2007: Williams David A
A new mechanism of leukemia drug resistance?
The New England journal of medicine 2007;357(1):77-8.
2007: Mehta Parinda A; Ileri Talia; Harris Richard E; Williams David A; Mo Jun; Smolarek Teresa; Auerbach Arleen D; Kelly Patrick; Davies Stella M
Chemotherapy for myeloid malignancy in children with Fanconi anemia.
Pediatric blood & cancer 2007;48(7):668-72.
2007: Zhang Xiaoling; Sejas Daniel P; Qiu Yuhui; Williams David A; Pang Qishen
Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence.
Journal of cell science 2007;120(Pt 9):1572-83.
2007: Sejas Daniel P; Rani Reena; Qiu Yuhui; Zhang Xiaoling; Fagerlie Sara R; Nakano Hiroyasu; Williams David A; Pang Qishen
Inflammatory reactive oxygen species-mediated hemopoietic suppression in Fancc-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):5277-87.
2007: Will Elke; Bailey Jeff; Schuesler Todd; Modlich Ute; Balcik Brenden; Burzynski Ben; Witte David; Layh-Schmitt Gerlinde; Rudolph Cornelia; Schlegelberger Brigitte; von Kalle Christof; Baum Christopher; Sorrentino Brian P; Wagner Lars M; Kelly Patrick; Reeves Lilith; Williams David A
Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(4):782-91.
2007: Kelly Patrick F; Radtke Susan; von Kalle Christof; Balcik Brenden; Bohn Kimberley; Mueller Robin; Schuesler Todd; Haren Moira; Reeves Lilith; Cancelas Jose A; Leemhuis Thomas; Harris Richard; Auerbach Arleen D; Smith Franklin O; Davies Stella M; Williams David A
Stem cell collection and gene transfer in Fanconi anemia.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(1):211-9.
2006: Debidda Marcella; Williams David A; Zheng Yi
Rac1 GTPase regulates cell genomic stability and senescence.
The Journal of biological chemistry 2006;281(50):38519-28.
2006: Kalfa Theodosia A; Pushkaran Suvarnamala; Mohandas Narla; Hartwig John H; Fowler Velia M; Johnson James F; Joiner Clinton H; Williams David A; Zheng Yi
Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton.
Blood 2006;108(12):3637-45.
2006: Gu Yi; Chae Hee-Don; Siefring Jamie E; Jasti Aparna C; Hildeman David A; Williams David A
RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development.
Nature immunology 2006;7(11):1182-90.
2006: Williams David A; Xu Haiming; Cancelas Jose A
Children are not little adults: just ask their hematopoietic stem cells.
The Journal of clinical investigation 2006;116(10):2593-6.
2006: Ghiaur Gabriel; Lee Andrew; Bailey Jeff; Cancelas Jose A; Zheng Yi; Williams David A
Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment.
Blood 2006;108(6):2087-94.
2006: Cornetta K; Croop J; Dropcho E; Abonour R; Kieran M W; Kreissman S; Reeves L; Erickson L C; Williams D A
A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase.
Cancer gene therapy 2006;13(9):886-95.
2006: Cancelas Jose A; Jansen Michael; Williams David A
The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization.
Experimental hematology 2006;34(8):976-85.
2006: Guo Fukun; Debidda Marcella; Yang Linda; Williams David A; Zheng Yi
Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly.
The Journal of biological chemistry 2006;281(27):18652-9.
2006: Schambach Axel; Galla Melanie; Modlich Ute; Will Elke; Chandra Saurabh; Reeves Lilith; Colbert Melissa; Williams David A; von Kalle Christof; Baum Christopher
Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical research.
Experimental hematology 2006;34(5):588-92.
2006: Schambach Axel; Bohne Jens; Chandra Saurabh; Will Elke; Margison Geoffrey P; Williams David A; Baum Christopher
Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(2):391-400.
2006: Will Elke; Speidel Daniel; Wang Zheng; Ghiaur Gabriel; Rimek Andreas; Schiedlmeier Bernhard; Williams David A; Baum Christopher; Ostertag Wolfram; Klump Hannes
HOXB4 inhibits cell growth in a dose-dependent manner and sensitizes cells towards extrinsic cues.
Cell cycle (Georgetown, Tex.) 2006;5(1):14-22.
2006: Wang Lei; Yang Linda; Filippi Marie-Dominique; Williams David A; Zheng Yi
Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment.
Blood 2006;107(1):98-105.
2006: Nassar Nicolas; Cancelas Jose; Zheng Jie; Williams David A; Zheng Yi
Structure-function based design of small molecule inhibitors targeting Rho family GTPases.
Current topics in medicinal chemistry 2006;6(11):1109-16.
2006: Akbar Huzoor; Cancelas Jose; Williams David A; Zheng Jie; Zheng Yi
Rational design and applications of a Rac GTPase-specific small molecule inhibitor.
Methods in enzymology 2006;406():554-65.
2005: Chandra Saurabh; Levran Orna; Jurickova Ingrid; Maas Chiel; Kapur Rick; Schindler Detlev; Henry Rashida; Milton Kelly; Batish Sat Dev; Cancelas Jose A; Hanenberg Helmut; Auerbach Arleen D; Williams David A
A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(5):976-84.
2005: Williams David A; Croop James; Kelly Patrick
Gene therapy in the treatment of Fanconi anemia, a progressive bone marrow failure syndrome.
Current opinion in molecular therapeutics 2005;7(5):461-6.
2005: Cancelas Jose A; Lee Andrew W; Prabhakar Rethinasamy; Stringer Keith F; Zheng Yi; Williams David A
Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization.
Nature medicine 2005;11(8):886-91.
2005: Fulkerson Patricia C; Zhu Hongyan; Williams David A; Zimmermann Nives; Rothenberg Marc E
CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism.
Blood 2005;106(2):436-43.
2005: Carstanjen Dirk; Yamauchi Akira; Koornneef Annemart; Zang Heesuk; Filippi Marie-Dominique; Harris Chad; Towe Jason; Atkinson Simon; Zheng Yi; Dinauer Mary C; Williams David A
Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4613-20.
2005: Jansen Michael; Yang Feng-Chun; Cancelas José A; Bailey Jeff R; Williams David A
Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure.
Stem cells (Dayton, Ohio) 2005;23(3):335-46.
2005: Gu Yi; Zheng Yi; Williams David A
RhoH GTPase: a key regulator of hematopoietic cell proliferation and apoptosis?
Cell cycle (Georgetown, Tex.) 2005;4(2):201-2.
2004: Filippi Marie-Dominique; Harris Chad E; Meller Jarek; Gu Yi; Zheng Yi; Williams David A
Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils.
Nature immunology 2004;5(7):744-51.
2004: Baum Christopher; von Kalle Christof; Staal Frank J T; Li Zhixiong; Fehse Boris; Schmidt Manfred; Weerkamp Floor; Karlsson Stefan; Wagemaker Gerard; Williams David A
Chance or necessity? Insertional mutagenesis in gene therapy and its consequences.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(1):5-13.
2003: Kreklau Emiko L; Pollok Karen E; Bailey Barbara J; Liu Naili; Hartwell Jennifer R; Williams David A; Erickson Leonard C
Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea.
Molecular cancer therapeutics 2003;2(12):1321-9.
2003: Yang Feng-Chun; Ingram David A; Chen Shi; Hingtgen Cynthia M; Ratner Nancy; Monk Kelly R; Clegg Travis; White Hilary; Mead Laura; Wenning Mary Jo; Williams David A; Kapur Reuben; Atkinson Simon J; Clapp D Wade
Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells.
The Journal of clinical investigation 2003;112(12):1851-61.
2003: Pollok Karen E; Hartwell Jennifer R; Braber Annemarije; Cooper Ryan J; Jansen Michael; Ragg Susanne; Bailey Barbara J; Erickson Leonard C; Kreklau Emiko L; Williams David A
In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations.
Human gene therapy 2003;14(18):1703-14.
2003: Chandra Saurabh; Kapur Reuben; Chuzhanova Nadia; Summey Victoria; Prentice David; Barker Jane; Cooper David N; Williams David A
A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype.
Blood 2003;102(10):3548-55.
2003: Gu Yi; Filippi Marie-Dominique; Cancelas Jose A; Siefring Jamie E; Williams Emily P; Jasti Aparna C; Harris Chad E; Lee Andrew W; Prabhakar Rethinasamy; Atkinson Simon J; Kwiatkowski David J; Williams David A
Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases.
Science (New York, N.Y.) 2003;302(5644):445-9.
2003: Williams David A; Baum Christopher
Medicine. Gene therapy--new challenges ahead.
Science (New York, N.Y.) 2003;302(5644):400-1.
2003: Woods Erik J; Liu Jun; Pollok Karen; Hartwell Jennifer; Smith Franklin O; Williams David A; Yoder Mervin C; Critser John K
A theoretically optimized method for cord blood stem cell cryopreservation.
Journal of hematotherapy & stem cell research 2003;12(3):341-50.
2003: Tan Bai Lin; Yazicioglu Mustafa N; Ingram David; McCarthy Jennifer; Borneo Jovencio; Williams David A; Kapur Reuben
Genetic evidence for convergence of c-Kit- and alpha4 integrin-mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells.
Blood 2003;101(12):4725-32.
2003: Leurs Cordula; Jansen Michael; Pollok Karen E; Heinkelein Martin; Schmidt Manfred; Wissler Manuela; Lindemann Dirk; Von Kalle Christof; Rethwilm Axel; Williams David A; Hanenberg Helmut
Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells.
Human gene therapy 2003;14(6):509-19.
2003: Baum Christopher; Düllmann Jochen; Li Zhixiong; Fehse Boris; Meyer Johann; Williams David A; von Kalle Christof
Side effects of retroviral gene transfer into hematopoietic stem cells.
Blood 2003;101(6):2099-114.
2002: Gu Yi; Williams David A
RAC2 GTPase deficiency and myeloid cell dysfunction in human and mouse.
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 2002;24(9):791-4.
2002: Gu Yi; Byrne Michael C; Paranavitana Nivanka C; Aronow Bruce; Siefring Jamie E; D'Souza Maria; Horton Heidi F; Quilliam Lawrence A; Williams David A
Rac2, a hematopoiesis-specific Rho GTPase, specifically regulates mast cell protease gene expression in bone marrow-derived mast cells.
Molecular and cellular biology 2002;22(21):7645-57.
2002: Kapur Reuben; Chandra Saurabh; Cooper Ryan; McCarthy Jennifer; Williams David A
Role of p38 and ERK MAP kinase in proliferation of erythroid progenitors in response to stimulation by soluble and membrane isoforms of stem cell factor.
Blood 2002;100(4):1287-93.
2002: Hanenberg Helmut; Batish Sat Dev; Pollok Karen E; Vieten Lydia; Verlander Peter C; Leurs Cordula; Cooper Ryan J; Göttsche Kerstin; Haneline Laura; Clapp D Wade; Lobitz Stephan; Williams David A; Auerbach Arleen D
Phenotypic correction of primary Fanconi anemia T cells with retroviral vectors as a diagnostic tool.
Experimental hematology 2002;30(5):410-20.
2001: Pollok K E; van Der Loo J C; Cooper R J; Hartwell J R; Miles K R; Breese R; Williams E P; Montel A; Seshadri R; Hanenberg H; Williams D A
Differential transduction efficiency of SCID-repopulating cells derived from umbilical cord blood and granulocyte colony-stimulating factor-mobilized peripheral blood.
Human gene therapy 2001;12(17):2095-108.
2001: Croop J M; Cooper R; Fernandez C; Graves V; Kreissman S; Hanenberg H; Smith F O; Williams D A
Mobilization and collection of peripheral blood CD34+ cells from patients with Fanconi anemia.
Blood 2001;98(10):2917-21.
2001: Ingram D A; Hiatt K; King A J; Fisher L; Shivakumar R; Derstine C; Wenning M J; Diaz B; Travers J B; Hood A; Marshall M; Williams D A; Clapp D W
Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro.
The Journal of experimental medicine 2001;194(1):57-69.
2001: Kobune M; Xu Y; Baum C; Kelley M R; Williams D A
Retrovirus-mediated expression of the base excision repair proteins, formamidopyrimidine DNA glycosylase or human oxoguanine DNA glycosylase, protects hematopoietic cells from N,N',N"-triethylenethiophosphoramide (thioTEPA)-induced toxicity in vitro and in vivo.
Cancer research 2001;61(13):5116-25.
2001: Schmidt M; Hoffmann G; Wissler M; Lemke N; Müssig A; Glimm H; Williams D A; Ragg S; Hesemann C U; von Kalle C
Detection and direct genomic sequencing of multiple rare unknown flanking DNA in highly complex samples.
Human gene therapy 2001;12(7):743-9.
2001: Yang F C; Atkinson S J; Gu Y; Borneo J B; Roberts A W; Zheng Y; Pennington J; Williams D A
Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5614-8.
2001: Gu Y; Jia B; Yang F C; D'Souza M; Harris C E; Derrow C W; Zheng Y; Williams D A
Biochemical and biological characterization of a human Rac2 GTPase mutant associated with phagocytic immunodeficiency.
The Journal of biological chemistry 2001;276(19):15929-38.
2001: Chen J; Reeves L; Sanburn N; Croop J; Williams D A; Cornetta K
Packaging cell line DNA contamination of vector supernatants: implication for laboratory and clinical research.
Virology 2001;282(1):186-97.
2001: Xu Y; Hansen W K; Rosenquist T A; Williams D A; Limp-Foster M; Kelley M R
Protection of mammalian cells against chemotherapeutic agents thiotepa, 1,3-N,N'-bis(2-chloroethyl)-N-nitrosourea, and mafosfamide using the DNA base excision repair genes Fpg and alpha-hOgg1: implications for protective gene therapy applications.
The Journal of pharmacology and experimental therapeutics 2001;296(3):825-31.
2001: Williams D A
Inflammatory cytokines and mucosal injury.
Journal of the National Cancer Institute. Monographs 2001;(29):26-30.
2000: Croop J M; Cooper R; Seshadri R; Fernandez C; Graves V; Kreissman S; Smith F O; Cornetta K; Williams D A; Abonour R
Large-scale mobilization and isolation of CD34+ cells from normal donors.
Bone marrow transplantation 2000;26(12):1271-9.
2000: Williams D A; Smith F O
Progress in the use of gene transfer methods to treat genetic blood diseases.
Human gene therapy 2000;11(15):2059-66.
2000: Ragg S; Xu-Welliver M; Bailey J; D'Souza M; Cooper R; Chandra S; Seshadri R; Pegg A E; Williams D A
Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells.
Cancer research 2000;60(18):5187-95.
2000: Williams D A; Tao W; Yang F; Kim C; Gu Y; Mansfield P; Levine J E; Petryniak B; Derrow C W; Harris C; Jia B; Zheng Y; Ambruso D R; Lowe J B; Atkinson S J; Dinauer M C; Boxer L
Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.
Blood 2000;96(5):1646-54.
2000: Abonour R; Williams D A; Einhorn L; Hall K M; Chen J; Coffman J; Traycoff C M; Bank A; Kato I; Ward M; Williams S D; Hromas R; Robertson M J; Smith F O; Woo D; Mills B; Srour E F; Cornetta K
Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells.
Nature medicine 2000;6(6):652-8.
2000: Williams D A; Maze R; Kurpad C; Pegg A; Erickson L C
Protection of hematopoietic cells against combined O6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O6-methylguanine DNA methyltransferase.
Bone marrow transplantation 2000;25 Suppl 2():S105-9.
2000: Yang F C; Kapur R; King A J; Tao W; Kim C; Borneo J; Breese R; Marshall M; Dinauer M C; Williams D A
Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells.
Immunity 2000;12(5):557-68.
2000: Woods E J; Liu J; Derrow C W; Smith F O; Williams D A; Critser J K
Osmometric and permeability characteristics of human placental/umbilical cord blood CD34+ cells and their application to cryopreservation.
Journal of hematotherapy & stem cell research 2000;9(2):161-73.
2000: Ingram D A; Yang F C; Travers J B; Wenning M J; Hiatt K; New S; Hood A; Shannon K; Williams D A; Clapp D W
Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo.
The Journal of experimental medicine 2000;191(1):181-8.
1999: Kreklau E L; Kurpad C; Williams D A; Erickson L C
Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo.
The Journal of pharmacology and experimental therapeutics 1999;291(3):1269-75.
1999: Pollok K E; Williams D A
Facilitation of retrovirus-mediated gene transfer into hematopoietic stem and progenitor cells and peripheral blood T-lymphocytes utilizing recombinant fibronectin fragments.
Current opinion in molecular therapeutics 1999;1(5):595-604.
1999: Pollok K E; van der Loo J C; Cooper R J; Kennedy L; Williams D A
Costimulation of transduced T lymphocytes via T cell receptor-CD3 complex and CD28 leads to increased transcription of integrated retrovirus.
Human gene therapy 1999;10(13):2221-36.
1999: Grosfeld J L; Du X; Williams D A
Interleukin-11: its biology and prospects for clinical use.
JPEN. Journal of parenteral and enteral nutrition 1999;23(5 Suppl):S67-9.
1999: Maze R; Kurpad C; Pegg A E; Erickson L C; Williams D A
Retroviral-mediated expression of the P140A, but not P140A/G156A, mutant form of O6-methylguanine DNA methyltransferase protects hematopoietic cells against O6-benzylguanine sensitization to chloroethylnitrosourea treatment.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1467-74.
1999: MacNeill E C; Hanenberg H; Pollok K E; van der Loo J C; Bierhuizen M F; Wagemaker G; Williams D A
Simultaneous infection with retroviruses pseudotyped with different envelope proteins bypasses viral receptor interference associated with colocalization of gp70 and target cells on fibronectin CH-296.
Journal of virology 1999;73(5):3960-7.
1999: Roberts A W; Kim C; Zhen L; Lowe J B; Kapur R; Petryniak B; Spaetti A; Pollock J D; Borneo J B; Bradford G B; Atkinson S J; Dinauer M C; Williams D A
Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense.
Immunity 1999;10(2):183-96.
1998: Jakacki R I; Jamison C; Mathews V P; Heilman D K; Dropcho E; Cornetta K; Macdonald D R; Williams D A
Dose-intensification of procarbazine, CCNU (lomustine), vincristine (PCV) with peripheral blood stem cell support in young patients with gliomas.
Medical and pediatric oncology 1998;31(6):483-90.
1998: van der Loo J C; Hanenberg H; Cooper R J; Luo F Y; Lazaridis E N; Williams D A
Nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mouse as a model system to study the engraftment and mobilization of human peripheral blood stem cells.
Blood 1998;92(7):2556-70.
1998: van der Loo J C; Xiao X; McMillin D; Hashino K; Kato I; Williams D A
VLA-5 is expressed by mouse and human long-term repopulating hematopoietic cells and mediates adhesion to extracellular matrix protein fibronectin.
The Journal of clinical investigation 1998;102(5):1051-61.
1998: Travers J B; Murphy R C; Johnson C A; Pei Y; Morin S M; Clay K L; Barber L A; Hood A F; Morelli J G; Williams D A
Identification and pharmacological characterization of platelet-activating factor and related 1-palmitoyl species in human inflammatory blistering diseases.
Prostaglandins & other lipid mediators 1998;56(5-6):305-24.
1998: Pei Y; Barber L A; Murphy R C; Johnson C A; Kelley S W; Dy L C; Fertel R H; Nguyen T M; Williams D A; Travers J B
Activation of the epidermal platelet-activating factor receptor results in cytokine and cyclooxygenase-2 biosynthesis.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):1954-61.
1998: Pollok K E; Hanenberg H; Noblitt T W; Schroeder W L; Kato I; Emanuel D; Williams D A
High-efficiency gene transfer into normal and adenosine deaminase-deficient T lymphocytes is mediated by transduction on recombinant fibronectin fragments.
Journal of virology 1998;72(6):4882-92.
1998: Veena P; Traycoff C M; Williams D A; McMahel J; Rice S; Cornetta K; Srour E F
Delayed targeting of cytokine-nonresponsive human bone marrow CD34(+) cells with retrovirus-mediated gene transfer enhances transduction efficiency and long-term expression of transduced genes.
Blood 1998;91(10):3693-701.
1998: Kapur R; Majumdar M; Xiao X; McAndrews-Hill M; Schindler K; Williams D A
Signaling through the interaction of membrane-restricted stem cell factor and c-kit receptor tyrosine kinase: genetic evidence for a differential role in erythropoiesis.
Blood 1998;91(3):879-89.
1998: Fiore N F; Ledniczky G; Liu Q; Orazi A; Du X; Williams D A; Grosfeld J L
Comparison of interleukin-11 and epidermal growth factor on residual small intestine after massive small bowel resection.
Journal of pediatric surgery 1998;33(1):24-9.
1998: Hansen W K; Deutsch W A; Yacoub A; Xu Y; Williams D A; Kelley M R
Creation of a fully functional human chimeric DNA repair protein. Combining O6-methylguanine DNA methyltransferase (MGMT) and AP endonuclease (APE/redox effector factor 1 (Ref 1)) DNA repair proteins.
The Journal of biological chemistry 1998;273(2):756-62.
1997: Hanenberg H; Hashino K; Konishi H; Hock R A; Kato I; Williams D A
Optimization of fibronectin-assisted retroviral gene transfer into human CD34+ hematopoietic cells.
Human gene therapy 1997;8(18):2193-206.
1997: Kapur R; Everett E T; Uffman J; McAndrews-Hill M; Cooper R; Ryder J; Vik T; Williams D A
Overexpression of human stem cell factor impairs melanocyte, mast cell, and thymocyte development: a role for receptor tyrosine kinase-mediated mitogen activated protein kinase activation in cell differentiation.
Blood 1997;90(8):3018-26.
1997: Du X; Williams D A
Interleukin-11: review of molecular, cell biology, and clinical use.
Blood 1997;89(11):3897-908.
1997: Du X; Liu Q; Yang Z; Orazi A; Rescorla F J; Grosfeld J L; Williams D A
Protective effects of interleukin-11 in a murine model of ischemic bowel necrosis.
The American journal of physiology 1997;272(3 Pt 1):G545-52.
1997: Maze R; Kapur R; Kelley M R; Hansen W K; Oh S Y; Williams D A
Reversal of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced severe immunodeficiency by transduction of murine long-lived hemopoietic progenitor cells using O6-methylguanine DNA methyltransferase complementary DNA.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(2):1006-13.
1996: Larochelle A; Vormoor J; Hanenberg H; Wang J C; Bhatia M; Lapidot T; Moritz T; Murdoch B; Xiao X L; Kato I; Williams D A; Dick J E
Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy.
Nature medicine 1996;2(12):1329-37.
1996: Rackoff W R; Orazi A; Robinson C A; Cooper R J; Alter B P; Freedman M H; Harris R E; Williams D A
Prolonged administration of granulocyte colony-stimulating factor (filgrastim) to patients with Fanconi anemia: a pilot study.
Blood 1996;88(5):1588-93.
1996: Liu Q; Du X X; Schindel D T; Yang Z X; Rescorla F J; Williams D A; Grosfeld J L
Trophic effects of interleukin-11 in rats with experimental short bowel syndrome.
Journal of pediatric surgery 1996;31(8):1047-50; discussion 1050-1.
1996: Hanenberg H; Xiao X L; Dilloo D; Hashino K; Kato I; Williams D A
Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells.
Nature medicine 1996;2(8):876-82.
1996: Moritz T; Dutt P; Xiao X; Carstanjen D; Vik T; Hanenberg H; Williams D A
Fibronectin improves transduction of reconstituting hematopoietic stem cells by retroviral vectors: evidence of direct viral binding to chymotryptic carboxy-terminal fragments.
Blood 1996;88(3):855-62.
1996: Yoder M C; Cumming J G; Hiatt K; Mukherjee P; Williams D A
A novel method of myeloablation to enhance engraftment of adult bone marrow cells in newborn mice.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 1996;2(2):59-67.
1996: Majumdar M K; Everett E T; Xiao X; Cooper R; Langley K; Kapur R; Vik T; Williams D A
Xenogeneic expression of human stem cell factor in transgenic mice mimics codominant c-kit mutations.
Blood 1996;87(8):3203-11.
1996: Maze R; Carney J P; Kelley M R; Glassner B J; Williams D A; Samson L
Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):206-10.
1995: Yoder M C; King B; Hiatt K; Williams D A
Murine embryonic yolk sac cells promote in vitro proliferation of bone marrow high proliferative potential colony-forming cells.
Blood 1995;86(4):1322-30.
1995: Du X X; Scott D; Yang Z X; Cooper R; Xiao X L; Williams D A
Interleukin-11 stimulates multilineage progenitors, but not stem cells, in murine and human long-term marrow cultures.
Blood 1995;86(1):128-34.
1995: Moritz T; Mackay W; Glassner B J; Williams D A; Samson L
Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo.
Cancer research 1995;55(12):2608-14.
1995: Du X; Williams D A
Update on development of interleukin-11.
Current opinion in hematology 1995;2(3):182-8.
1994: Moritz T; Williams D A
Gene transfer into the hematopoietic system.
Current opinion in hematology 1994;1(6):423-8.
1994: Maze R; Moritz T; Williams D A
Increased survival and multilineage hematopoietic protection from delayed and severe myelosuppressive effects of a nitrosourea with recombinant interleukin-11.
Cancer research 1994;54(18):4947-51.
1994: Yoder M C; Papaioannou V E; Breitfeld P P; Williams D A
Murine yolk sac endoderm- and mesoderm-derived cell lines support in vitro growth and differentiation of hematopoietic cells.
Blood 1994;83(9):2436-43.
1994: Moritz T; Patel V P; Williams D A
Bone marrow extracellular matrix molecules improve gene transfer into human hematopoietic cells via retroviral vectors.
The Journal of clinical investigation 1994;93(4):1451-7.
1994: Du X X; Williams D A
Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment.
Blood 1994;83(8):2023-30.
1994: Majumdar M K; Feng L; Medlock E; Toksoz D; Williams D A
Identification and mutation of primary and secondary proteolytic cleavage sites in murine stem cell factor cDNA yields biologically active, cell-associated protein.
The Journal of biological chemistry 1994;269(2):1237-42.
1994: Williams D A; Moritz T
Umbilical cord blood stem cells as targets for genetic modification: new therapeutic approaches to somatic gene therapy.
Blood cells 1994;20(2-3):504-15; discussion 515-6.
1994: Williams D A; Moritz T
Genetic manipulation of hematopoietic stem cells in adenosine deaminase deficiency.
Advances in experimental medicine and biology 1994;370():395-400.
1994: Williams D A; Majumdar M K
Analysis of steel factor (stem cell factor) isoforms in the hematopoietic microenvironment.
Stem cells (Dayton, Ohio) 1994;12 Suppl 1():67-74; discussion 75-7.
1993: Keller D C; Du X X; Srour E F; Hoffman R; Williams D A
Interleukin-11 inhibits adipogenesis and stimulates myelopoiesis in human long-term marrow cultures.
Blood 1993;82(5):1428-35.
1993: Moritz T; Keller D C; Williams D A
Human cord blood cells as targets for gene transfer: potential use in genetic therapies of severe combined immunodeficiency disease.
The Journal of experimental medicine 1993;178(2):529-36.
1993: Du X X; Keller D; Maze R; Williams D A
Comparative effects of in vivo treatment using interleukin-11 and stem cell factor on reconstitution in mice after bone marrow transplantation.
Blood 1993;82(3):1016-22.
1993: Yoder M C; Du X X; Williams D A
High proliferative potential colony-forming cell heterogeneity identified using counterflow centrifugal elutriation.
Blood 1993;82(2):385-91.
1993: Majumdar M K; McAndrews-Hill M; Williams D A
A rapid protocol for the purification of plasmid DNA template suitable for DNA sequencing.
Analytical biochemistry 1993;208(2):403-4.
1993: Du X X; Neben T; Goldman S; Williams D A
Effects of recombinant human interleukin-11 on hematopoietic reconstitution in transplant mice: acceleration of recovery of peripheral blood neutrophils and platelets.
Blood 1993;81(1):27-34.
1992: Majumdar M K; Williams D A
Minipreparations of plasmid DNA directly from cell culture by the boiling method.
BioTechniques 1992;13(3):366.
1992: Luskey B D; Rosenblatt M; Zsebo K; Williams D A
Stem cell factor, interleukin-3, and interleukin-6 promote retroviral-mediated gene transfer into murine hematopoietic stem cells.
Blood 1992;80(2):396-402.

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