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David Williams

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Physiology

Signal Transduction

Anatomy

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Sepsis

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Co-Publications
Name
23
Ha, Tuanzhu
23
Li, Chuanfu
20
Kalbfleisch, John
19
Browder, William
16
Kelley, Jim
13
Kao, Race
10
Hua, Fang
10
Rice, Peter
9
Ma, Jing
8
Ozment-Skelton, Tammy
8
Breuel, Kevin
8
Gao, Xiang
7
Ensley, Harry
6
Browder, William
6
Schweitzer, John

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Publications

TOP 3
Kruppa Michael D; Lowman Douglas W; Chen Yu-Han; Selander Christine; Scheynius Annika; Monteiro Mario A; Williams David L
Identification of (1-->6)-beta-D-glucan as the major carbohydrate component of the Malassezia sympodialis cell wall.
Shah Vaibhav B; Williams David L; Keshvara Lakhu
beta-Glucan attenuates TLR2- and TLR4-mediated cytokine production by microglia.
Shah Vaibhav B; Ozment-Skelton Tammy R; Williams David L; Keshvara Lakhu
Vav1 and PI3K are required for phagocytosis of beta-glucan and subsequent superoxide generation by microglia.

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All Publications

2009: Kruppa Michael D; Lowman Douglas W; Chen Yu-Han; Selander Christine; Scheynius Annika; Monteiro Mario A; Williams David L
Identification of (1-->6)-beta-D-glucan as the major carbohydrate component of the Malassezia sympodialis cell wall.
Carbohydrate research 2009;344(18):2474-9.
2009: Shah Vaibhav B; Williams David L; Keshvara Lakhu
beta-Glucan attenuates TLR2- and TLR4-mediated cytokine production by microglia.
Neuroscience letters 2009;458(3):111-5.
2009: Shah Vaibhav B; Ozment-Skelton Tammy R; Williams David L; Keshvara Lakhu
Vav1 and PI3K are required for phagocytosis of beta-glucan and subsequent superoxide generation by microglia.
Molecular immunology 2009;46(8-9):1845-53.
2009: Hua Fang; Ma Jing; Ha Tuanzhu; Kelley Jim L; Kao Race L; Schweitzer John B; Kalbfleisch John H; Williams David L; Li Chuanfu
Differential roles of TLR2 and TLR4 in acute focal cerebral ischemia/reperfusion injury in mice.
Brain research 2009;1262():100-8.
2009: Ozment-Skelton Tammy R; deFluiter Elizabeth A; Ha Tuanzhu; Li Chuanfu; Graves Bridget M; Ferguson Donald A; Schweitzer John B; Preizsner Johanna; Brown Gordon D; Gordon Siamon; Kalbfleisch John H; Williams David L
Leukocyte Dectin-1 expression is differentially regulated in fungal versus polymicrobial sepsis.
Critical care medicine 2009;37(3):1038-45.
2008: Hua Fang; Ma Jing; Ha Tuanzhu; Kelley Jim; Williams David L; Kao Race L; Kalbfleisch John H; Browder I William; Li Chuanfu
Preconditioning with a TLR2 specific ligand increases resistance to cerebral ischemia/reperfusion injury.
Journal of neuroimmunology 2008;199(1-2):75-82.
2008: Ha Tuanzhu; Hua Fang; Liu Xiang; Ma Jing; McMullen Julie R; Shioi Tetsuo; Izumo Seigo; Kelley Jim; Gao Xiag; Browder William; Williams David L; Kao Race L; Li Chuanfu
Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism.
Cardiovascular research 2008;78(3):546-53.
2008: Adams Elizabeth L; Rice Peter J; Graves Bridget; Ensley Harry E; Yu Hai; Brown Gordon D; Gordon Siamon; Monteiro Mario A; Papp-Szabo Erzsebet; Lowman Douglas W; Power Trevor D; Wempe Michael F; Williams David L
Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching.
The Journal of pharmacology and experimental therapeutics 2008;325(1):115-23.
2008: Shah Vaibhav B; Huang Yongcheng; Keshwara Rohan; Ozment-Skelton Tammy; Williams David L; Keshvara Lakhu
Beta-glucan activates microglia without inducing cytokine production in Dectin-1-dependent manner.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):2777-85.
2007: Hua Fang; Ma Jing; Ha Tuanzhu; Xia Yeling; Kelley Jim; Williams David L; Kao Race L; Browder I William; Schweitzer John B; Kalbfleisch John H; Li Chuanfu
Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion.
Journal of neuroimmunology 2007;190(1-2):101-11.
2007: Fan Hongkuan; Williams David L; Zingarelli Basilia; Breuel Kevin F; Teti Giuseppe; Tempel George E; Spicher Karsten; Boulay Guylain; Birnbaumer Lutz; Halushka Perry V; Cook James A
Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins.
Immunology 2007;122(1):116-23.
2007: Hua Fang; Ha Tuanzhu; Ma Jing; Li Yan; Kelley Jim; Gao Xiang; Browder I William; Kao Race L; Williams David L; Li Chuanfu
Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):7317-24.
2006: Fan Hongkuan; Williams David L; Zingarelli Basilia; Breuel Kevin F; Teti Giuseppe; Tempel George E; Spicher Karsten; Boulay Guylain; Birnbaumer Lutz; Halushka Perry V; Cook James A
Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins.
Biochimica et biophysica acta 2006;1763(10):1051-8.
2006: Ha Tuanzhu; Hua Fang; Grant Daniel; Xia Yeling; Ma Jing; Gao Xiang; Kelley Jim; Williams David L; Kalbfleisch John; Browder I William; Kao Race L; Li Chuanfu
Glucan phosphate attenuates cardiac dysfunction and inhibits cardiac MIF expression and apoptosis in septic mice.
American journal of physiology. Heart and circulatory physiology 2006;291(4):H1910-8.
2006: Ozment-Skelton Tammy R; Goldman Matthew P; Gordon Siamon; Brown Gordon D; Williams David L
Prolonged reduction of leukocyte membrane-associated Dectin-1 levels following beta-glucan administration.
The Journal of pharmacology and experimental therapeutics 2006;318(2):540-6.
2006: Williams David L; Ozment-Skelton Tammy; Li Chaunfu
Modulation of the phosphoinositide 3-kinase signaling pathway alters host response to sepsis, inflammation, and ischemia/reperfusion injury.
Shock (Augusta, Ga.) 2006;25(5):432-9.
2006: Hua Fang; Ma Jing; Li Yan; Ha Tuanzhu; Xia Yeling; Kelley Jim; Williams David L; Browder I William; Schweitzer John B; Li Chuanfu
The development of a novel mouse model of transient global cerebral ischemia.
Neuroscience letters 2006;400(1-2):69-74.
2006: Ha Tuanzhu; Hua Fang; Li Yuehua; Ma Jing; Gao Xiang; Kelley Jim; Zhao Aiqiu; Haddad Georges E; Williams David L; Browder I William; Kao Race L; Li Chuanfu
Blockade of MyD88 attenuates cardiac hypertrophy and decreases cardiac myocyte apoptosis in pressure overload-induced cardiac hypertrophy in vivo.
American journal of physiology. Heart and circulatory physiology 2006;290(3):H985-94.
2006: Fan Hongkuan; Williams David L; Breuel Kevin F; Zingarelli Basilia; Teti Giuseppe; Tempel George E; Halushka Perry V; Cook James A
Gi proteins regulate lipopolysaccharide and Staphylococcus aureus induced cytokine production but not (1--> 3)-beta-D-glucan induced cytokine suppression.
Frontiers in bioscience : a journal and virtual library 2006;11():2264-74.
2005: Ha Tuanzhu; Li Yuehua; Gao Xiang; McMullen Julie R; Shioi Tetsuo; Izumo Seigo; Kelley Jim L; Zhao Aiqiu; Haddad Georges E; Williams David L; Browder I William; Kao Race L; Li Chuanfu
Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo.
Free radical biology & medicine 2005;39(12):1570-80.
2005: Hua Fang; Ha Tuanzhu; Ma Jing; Gao Xiang; Kelley Jim; Williams David L; Browder I William; Kao Race L; Li Chuanfu
Blocking the MyD88-dependent pathway protects the myocardium from ischemia/reperfusion injury in rat hearts.
Biochemical and biophysical research communications 2005;338(2):1118-25.
2005: Fan Wei; Ha Tuanzhu; Li Yan; Ozment-Skelton Tammy; Williams David L; Kelley Jim; Browder I William; Li Chuanfu
Overexpression of TLR2 and TLR4 susceptibility to serum deprivation-induced apoptosis in CHO cells.
Biochemical and biophysical research communications 2005;337(3):840-8.
2005: Ha Tuanzhu; Li Yuehua; Hua Fang; Ma Jinag; Gao Xiang; Kelley Jim; Zhao Aiqiu; Haddad Georges E; Williams David L; William Browder I; Kao Race L; Li Chuanfu
Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload.
Cardiovascular research 2005;68(2):224-34.
2005: Rice Peter J; Adams Elizabeth L; Ozment-Skelton Tammy; Gonzalez Andres J; Goldman Matthew P; Lockhart Brent E; Barker Luke A; Breuel Kevin F; Deponti Warren K; Kalbfleisch John H; Ensley Harry E; Brown Gordon D; Gordon Siamon; Williams David L
Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge.
The Journal of pharmacology and experimental therapeutics 2005;314(3):1079-86.
2004: Li Yuehua; Ha Tuanzhu; Gao Xiang; Kelley Jim; Williams David L; Browder I William; Kao Race L; Li Chuanfu
NF-kappaB activation is required for the development of cardiac hypertrophy in vivo.
American journal of physiology. Heart and circulatory physiology 2004;287(4):H1712-20.
2004: Rice Peter J; Lockhart Brent E; Barker Luke A; Adams Elizabeth L; Ensley Harry E; Williams David L
Pharmacokinetics of fungal (1-3)-beta-D-glucans following intravenous administration in rats.
International immunopharmacology 2004;4(9):1209-15.
2004: Gonzalez J Andres; Digby Justin D; Rice Peter J; Breuel Kevin F; DePonti W Keith; Kalbfleisch John H; Browder I William; Williams David L
At low serum glucan concentrations there is an inverse correlation between serum glucan and serum cytokine levels in ICU patients with infections.
International immunopharmacology 2004;4(8):1107-15.
2004: Peck Octavia M; Williams David L; Breuel Kevin F; Kalbfleisch John H; Fan Hongkuan; Tempel George E; Teti Giuseppe; Cook James A
Differential regulation of cytokine and chemokine production in lipopolysaccharide-induced tolerance and priming.
Cytokine 2004;26(5):202-8.
2004: Li Chuanfu; Ha Tuanzhu; Kelley Jim; Gao Xiang; Qiu Yufeng; Kao Race L; Browder William; Williams David L
Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection.
Cardiovascular research 2004;61(3):538-47.
2004: Williams David L; Li Chuanfu; Ha Tuanzhu; Ozment-Skelton Tammy; Kalbfleisch John H; Preiszner Johanna; Brooks Lynne; Breuel Kevin; Schweitzer John B
Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):449-56.
2004: Breuel Kevin F; Kougias Panagiotis; Rice Peter J; Wei Duo; De Ponti Keith; Wang Jiakun; Laffan John J; Li Chuanfu; Kalbfleisch John; Williams David L
Anterior pituitary cells express pattern recognition receptors for fungal glucans: implications for neuroendocrine immune involvement in response to fungal infections.
Neuroimmunomodulation 2004;11(1):1-9.
2003: Williams David L; Ha Tuanzhu; Li Chuanfu; Kalbfleisch John H; Schweitzer John; Vogt William; Browder I William
Modulation of tissue Toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality.
Critical care medicine 2003;31(6):1808-18.
2003: Williams David L; Browder I William
Murine models of intestinal anastomoses.
Methods in molecular medicine 2003;78():133-40.
2002: Rice Peter J; Kelley Jim L; Kogan Grigorij; Ensley Harry E; Kalbfleisch John H; Browder I William; Williams David L
Human monocyte scavenger receptors are pattern recognition receptors for (1-->3)-beta-D-glucans.
Journal of leukocyte biology 2002;72(1):140-6.
2002: Lowe Elizabeth P; Wei Duo; Rice Peter J; Li Chuanfu; Kalbfleisch John; Browder I William; Williams David L
Human vascular endothelial cells express pattern recognition receptors for fungal glucans which stimulates nuclear factor kappaB activation and interleukin 8 production. Winner of the Best Paper Award from the Gold Medal Forum.
The American surgeon 2002;68(6):508-17; discussion 517-8.
2002: Wei Duo; Zhang Leiying; Williams David L; Browder I William
Glucan stimulates human dermal fibroblast collagen biosynthesis through a nuclear factor-1 dependent mechanism.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2002;10(3):161-8.
2001: Kougias P; Wei D; Rice P J; Ensley H E; Kalbfleisch J; Williams D L; Browder I W
Normal human fibroblasts express pattern recognition receptors for fungal (1-->3)-beta-D-glucans.
Infection and immunity 2001;69(6):3933-8.
2001: Li C; Kao R L; Ha T; Kelley J; Browder I W; Williams D L
Early activation of IKKbeta during in vivo myocardial ischemia.
American journal of physiology. Heart and circulatory physiology 2001;280(3):H1264-71.
2001: Tsiapali E; Whaley S; Kalbfleisch J; Ensley H E; Browder I W; Williams D L
Glucans exhibit weak antioxidant activity, but stimulate macrophage free radical activity.
Free radical biology & medicine 2001;30(4):393-402.
2000: Williams D L; Ha T; Li C; Laffan J; Kalbfleisch J; Browder W
Inhibition of LPS-induced NFkappaB activation by a glucan ligand involves down-regulation of IKKbeta kinase activity and altered phosphorylation and degradation of IkappaBalpha.
Shock (Augusta, Ga.) 2000;13(6):446-52.
2000: Mueller A; Raptis J; Rice P J; Kalbfleisch J H; Stout R D; Ensley H E; Browder W; Williams D L
The influence of glucan polymer structure and solution conformation on binding to (1-->3)-beta-D-glucan receptors in a human monocyte-like cell line.
Glycobiology 2000;10(4):339-46.
1999: Williams D L; Ha T; Li C; Kalbfleisch J H; Laffan J J; Ferguson D A
Inhibiting early activation of tissue nuclear factor-kappa B and nuclear factor interleukin 6 with (1-->3)-beta-D-glucan increases long-term survival in polymicrobial sepsis.
Surgery 1999;126(1):54-65.
1999: Williams D L; Ha T; Li C; Kalbfleisch J H; Ferguson D A
Early activation of hepatic NFkappaB and NF-IL6 in polymicrobial sepsis correlates with bacteremia, cytokine expression, and mortality.
Annals of surgery 1999;230(1):95-104.
1999: Browder W; Ha T; Chuanfu L; Kalbfleisch J H; Ferguson D A; Williams D L
Early activation of pulmonary nuclear factor kappaB and nuclear factor interleukin-6 in polymicrobial sepsis.
The Journal of trauma 1999;46(4):590-6.
1997: Portera C A; Love E J; Memore L; Zhang L; Müller A; Browder W; Williams D L
Effect of macrophage stimulation on collagen biosynthesis in the healing wound.
The American surgeon 1997;63(2):125-31.
1996: Müller A; Rice P J; Ensley H E; Coogan P S; Kalbfleish J H; Kelley J L; Love E J; Portera C A; Ha T; Browder I W; Williams D L
Receptor binding and internalization of a water-soluble (1-->3)-beta-D-glucan biologic response modifier in two monocyte/macrophage cell lines.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(9):3418-25.
1995: Müller A; Pretus H A; McNamee R B; Jones E L; Browder I W; Williams D L
Comparison of the carbohydrate biological response modifiers Krestin, schizophyllan and glucan phosphate by aqueous size exclusion chromatography with in-line argon-ion multi-angle laser light scattering photometry and differential viscometry detectors.
Journal of chromatography. B, Biomedical applications 1995;666(2):283-90.
1994: Ensley H E; Tobias B; Pretus H A; McNamee R B; Jones E L; Browder I W; Williams D L
NMR spectral analysis of a water-insoluble (1-->3)-beta-D-glucan isolated from Saccharomyces cerevisiae.
Carbohydrate research 1994;258():307-11.
1992: Williams D L; Pretus H A; McNamee R B; Jones E L; Ensley H E; Browder I W
Development of a water-soluble, sulfated (1-->3)-beta-D-glucan biological response modifier derived from Saccharomyces cerevisiae.
Carbohydrate research 1992;235():247-57.
1992: Williams D L; Pretus H A; McNamee R B; Jones E L
A sequential multi-assay protocol for the preclinical assessment of natural product complex carbohydrate immunomodulators.
Developments in biological standardization 1992;77():129-36.
1991: Williams D L; Pretus H A; McNamee R B; Jones E L; Ensley H E; Browder I W; Di Luzio N R
Development, physicochemical characterization and preclinical efficacy evaluation of a water soluble glucan sulfate derived from Saccharomyces cerevisiae.
Immunopharmacology 1991;22(3):139-55.
1991: Williams D L; McNamee R B; Jones E L; Pretus H A; Ensley H E; Browder I W; Di Luzio N R
A method for the solubilization of a (1----3)-beta-D-glucan isolated from Saccharomyces cerevisiae.
Carbohydrate research 1991;219():203-13.
1991: Pretus H A; Ensley H E; McNamee R B; Jones E L; Browder I W; Williams D L
Isolation, physicochemical characterization and preclinical efficacy evaluation of soluble scleroglucan.
The Journal of pharmacology and experimental therapeutics 1991;257(1):500-10.
1989: Pretus H A; Browder I W; Lucore P; McNamee R B; Jones E L; Williams D L
Macrophage activation decreases macrophage prostaglandin E2 release in experimental trauma.
The Journal of trauma 1989;29(8):1152-6; discussion 1156-7.
1989: Williams D L; Yaeger R G; Pretus H A; Browder I W; McNamee R B; Jones E L
Immunization against Trypanosoma cruzi: adjuvant effect of glucan.
International journal of immunopharmacology 1989;11(4):403-10.
1988: Williams D L; Sherwood E R; Browder I W; McNamee R B; Jones E L; Di Luzio N R
The role of complement in glucan-induced protection against septic shock.
Circulatory shock 1988;25(1):53-60.
1988: Sherwood E R; Williams D L; McNamee R B; Jones E L; Browder I W; Di Luzio N R
Soluble glucan and lymphokine-activated killer (LAK) cells in the therapy of experimental hepatic metastases.
Journal of biological response modifiers 1988;7(2):185-98.
1988: Williams D L; Sherwood E R; Browder I W; McNamee R B; Jones E L; Rakinic J; Di Luzio N R
Effect of glucan on neutrophil dynamics and immune function in Escherichia coli peritonitis.
The Journal of surgical research 1988;44(1):54-61.
1988: Williams D L; Sherwood E R; Browder I W; McNamee R B; Jones E L; Di Luzio N R
Pre-clinical safety evaluation of soluble glucan.
International journal of immunopharmacology 1988;10(4):405-14.
1987: Williams D L; Sherwood E R; McNamee R B; Jones E L; Browder I W; Di Luzio N R
Chemoimmunotherapy of experimental hepatic metastases.
Hepatology (Baltimore, Md.) 1987;7(6):1296-304.
1987: Sherwood E R; Williams D L; McNamee R B; Jones E L; Browder I W; Di Luzio N R
In vitro tumoricidal activity of resting and glucan-activated Kupffer cells.
Journal of leukocyte biology 1987;42(1):69-75.
1987: Sherwood E R; Williams D L; McNamee R B; Jones E L; Browder I W; Di Luzio N R
Enhancement of interleukin-1 and interleukin-2 production by soluble glucan.
International journal of immunopharmacology 1987;9(3):261-7.
1986: Sherwood E R; Williams D L; Di Luzio N R
Glucan stimulates production of antitumor cytolytic/cytostatic factor(s) by macrophages.
Journal of biological response modifiers 1986;5(6):504-26.
1986: Sherwood E R; Williams D L; Di Luzio N R
Comparison of the in vitro cytolytic effect of hepatic, splenic and peritoneal macrophages from glucan-treated mice on sarcoma M5076.
Methods and findings in experimental and clinical pharmacology 1986;8(3):157-61.
1985: Williams D L; Sherwood E R; McNamee R B; Jones E L; Di Luzio N R
Therapeutic efficacy of glucan in a murine model of hepatic metastatic disease.
Hepatology (Baltimore, Md.) 1985;5(2):198-206.
1985: Di Luzio N R; Williams D L; Sherwood E R; Browder I W
Modification of diverse experimental immunosuppressive states by glucan.
Survey of immunologic research 1985;4(2):160-7.

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