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Gary Brayer

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TOP 3
Leslie K Williams; Stephen G Withers; Chunmin Li; Gary D Brayer
Order and disorder: differential structural impacts of myricetin and ethyl caffeate on human amylase, an antidiabetic target.
Ran Zhang; Chunmin Li; Leslie K Williams; Brian P Rempel; Gary D Brayer; Stephen G Withers
Directed "in situ" inhibitor elongation as a strategy to structurally characterize the covalent glycosyl-enzyme intermediate of human pancreatic alpha-amylase.
Kush Dalal; Nham Nguyen; Meriem Alami; Jennifer Tan; Trevor F Moraes; Woo Cheol Lee; Robert Maurus; Stephen G Sligar; Gary D Brayer; Franck Duong
Structure, binding, and activity of Syd, a SecY-interacting protein.

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All Publications

2012: Leslie K Williams; Stephen G Withers; Chunmin Li; Gary D Brayer
Order and disorder: differential structural impacts of myricetin and ethyl caffeate on human amylase, an antidiabetic target.
Journal of medicinal chemistry 2012;55(22):10177-86.
2009: Ran Zhang; Chunmin Li; Leslie K Williams; Brian P Rempel; Gary D Brayer; Stephen G Withers
Directed "in situ" inhibitor elongation as a strategy to structurally characterize the covalent glycosyl-enzyme intermediate of human pancreatic alpha-amylase.
Biochemistry 2009;48(45):10752-64.
2009: Kush Dalal; Nham Nguyen; Meriem Alami; Jennifer Tan; Trevor F Moraes; Woo Cheol Lee; Robert Maurus; Stephen G Sligar; Gary D Brayer; Franck Duong
Structure, binding, and activity of Syd, a SecY-interacting protein.
The Journal of biological chemistry 2009;284(12):7897-902.
2008: Ran Zhang; John McCarter; Curtis Braun; Wai Yeung; Gary D Brayer; Stephen G Withers
Synthesis and testing of 2-deoxy-2,2-dihaloglycosides as mechanism-based inhibitors of alpha-glycosidases.
The Journal of organic chemistry 2008;73(8):3070-7.
2008: Roberto Quezada-Calvillo; Lyann Sim; Zihua Ao; Bruce R Hamaker; Andrea Quaroni; Gary D Brayer; Erwin E Sterchi; Claudia C Robayo-Torres; David R Rose; Buford L Nichols
Luminal starch substrate "brake" on maltase-glucoamylase activity is located within the glucoamylase subunit.
The Journal of nutrition 2008;138(4):685-92.
2008: Robert Maurus; Anjuman Begum; Leslie K Williams; Jason R Fredriksen; Ran Zhang; Stephen G Withers; Gary D Brayer
Alternative catalytic anions differentially modulate human alpha-amylase activity and specificity.
Biochemistry 2008;47(11):3332-44.
2008: Chris A Tarling; Kate Woods; Ran Zhang; Harry C Brastianos; Gary D Brayer; Raymond J Andersen; Stephen G Withers
The search for novel human pancreatic alpha-amylase inhibitors: high-throughput screening of terrestrial and marine natural product extracts.
Chembiochem : a European journal of chemical biology 2008;9(3):433-8.
2005: Chunmin Li; Anjuman Begum; Shin Numao; Kwan Hwa Park; Stephen G Withers; Gary D Brayer
Acarbose rearrangement mechanism implied by the kinetic and structural analysis of human pancreatic alpha-amylase in complex with analogues and their elongated counterparts.
Biochemistry 2005;44(9):3347-57.
2005: Robert Maurus; Anjuman Begum; Hsin-Hen Kuo; Andrew Racaza; Shin Numao; Carsten Andersen; Jeppe W Tams; Jesper Vind; Christopher M Overall; Stephen G Withers; Gary D Brayer
Structural and mechanistic studies of chloride induced activation of human pancreatic alpha-amylase.
Protein science : a publication of the Protein Society 2005;14(3):743-55.
2004: Shin Numao; Iben Damager; Chunmin Li; Tanja M Wrodnigg; Anjuman Begum; Christopher M Overall; Gary D Brayer; Stephen G Withers
In situ extension as an approach for identifying novel alpha-amylase inhibitors.
The Journal of biological chemistry 2004;279(46):48282-91.
2004: Iben Damager; Shin Numao; Hongming Chen; Gary D Brayer; Stephen G Withers
Synthesis and characterisation of novel chromogenic substrates for human pancreatic alpha-amylase.
Carbohydrate research 2004;339(10):1727-37.
2003: David J Stokell; Lynda J Donald; Robert Maurus; Nham T Nguyen; Gillian Sadler; Kajal Choudhary; Philip G Hultin; Gary D Brayer; Harry W Duckworth
Probing the roles of key residues in the unique regulatory NADH binding site of type II citrate synthase of Escherichia coli.
The Journal of biological chemistry 2003;278(37):35435-43.
2003: Robert Maurus; Nham T Nguyen; David J Stokell; Ayeda Ayed; Philip G Hultin; Harry W Duckworth; Gary D Brayer
Insights into the evolution of allosteric properties. The NADH binding site of hexameric type II citrate synthases.
Biochemistry 2003;42(19):5555-65.
2003: Christie L Hunter; Robert Maurus; Marcia R Mauk; Hung Lee; Emma L Raven; Harry Tong; Nham Nguyen; Michael Smith; Gary D Brayer; A Grant Mauk
Introduction and characterization of a functionally linked metal ion binding site at the exposed heme edge of myoglobin.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):3647-52.
2002: Edwin H Rydberg; Chunmin Li; Robert Maurus; Christopher M Overall; Gary D Brayer; Stephen G Withers
Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids.
Biochemistry 2002;41(13):4492-502.
2002: Shin Numao; Robert Maurus; Gary Sidhu; Yili Wang; Christopher M Overall; Gary D Brayer; Stephen G Withers
Probing the role of the chloride ion in the mechanism of human pancreatic alpha-amylase.
Biochemistry 2002;41(1):215-25.
2001: Nham T Nguyen; Robert Maurus; David J Stokell; Ayeda Ayed; Harry W Duckworth; Gary D Brayer
Comparative analysis of folding and substrate binding sites between regulated hexameric type II citrate synthases and unregulated dimeric type I enzymes.
Biochemistry 2001;40(44):13177-87.
2001: MD Joshi; Gary Sidhu; Jens Nielsen; Gary D Brayer; Stephen G Withers; Lawrence P McIntosh
Dissecting the electrostatic interactions and pH-dependent activity of a family 11 glycosidase.
Biochemistry 2001;40(34):10115-39.
2000: MD Joshi; Gary Sidhu; Isabelle Pot; Gary D Brayer; Stephen G Withers; Lawrence P McIntosh
Hydrogen bonding and catalysis: a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase.
Journal of molecular biology 2000;299(1):255-79.
2000: Gary D Brayer; Gary Sidhu; Robert Maurus; Edwin H Rydberg; C Braun; Yili Wang; Nham T Nguyen; Christopher M Overall; Stephen G Withers
Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.
Biochemistry 2000;39(16):4778-91.
2000: A H Yang; Ross T A MacGillivray; J Chen; Y Luo; Yili Wang; Gary D Brayer; Anne Mason; Robert C Woodworth; Michael E P Murphy
Crystal structures of two mutants (K206Q, H207E) of the N-lobe of human transferrin with increased affinity for iron.
Protein science : a publication of the Protein Society 2000;9(1):49-52.
1999: Gary Sidhu; Stephen G Withers; Nham T Nguyen; Lawrence P McIntosh; L Ziser; Gary D Brayer
Sugar ring distortion in the glycosyl-enzyme intermediate of a family G/11 xylanase.
Biochemistry 1999;38(17):5346-54.
1999: Edwin H Rydberg; Gary Sidhu; HC Vo; Jeff Hewitt; H C Côte; Yili Wang; Shin Numao; Ross T A MacGillivray; Christopher M Overall; Gary D Brayer; Stephen G Withers
Cloning, mutagenesis, and structural analysis of human pancreatic alpha-amylase expressed in Pichia pastoris.
Protein science : a publication of the Protein Society 1999;8(3):635-43.
1998: Ross T A MacGillivray; S A Moore; J Chen; Bryan F Anderson; H Baker; Y Luo; Maria C Bewley; Clyde Smith; Michael E P Murphy; Yili Wang; Anne Mason; Robert C Woodworth; Gary D Brayer; Edward N Baker
Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release.
Biochemistry 1998;37(22):7919-28.
1998: Robert Maurus; R Bogumil; Nham T Nguyen; A Grant Mauk; Gary D Brayer
Structural and spectroscopic studies of azide complexes of horse heart myoglobin and the His-64-->Thr variant.
The Biochemical journal 1998;332 ( Pt 1)():67-74.
1997: Robert Maurus; Christopher M Overall; R Bogumil; Y Luo; A Grant Mauk; Michael Smith; Gary D Brayer
A myoglobin variant with a polar substitution in a conserved hydrophobic cluster in the heme binding pocket.
Biochimica et biophysica acta 1997;1341(1):1-13.
1996: E Lloyd; D L Burk; J C Ferrer; Robert Maurus; J Doran; P R Carey; Gary D Brayer; A Grant Mauk
Electrostatic modification of the active site of myoglobin: characterization of the proximal Ser92Asp variant.
Biochemistry 1996;35(36):11901-12.
1996: S P Rafferty; J Guy Guillemette; Albert Berghuis; Michael Smith; Gary D Brayer; A Grant Mauk
Mechanistic and structural contributions of critical surface and internal residues to cytochrome c electron transfer reactivity.
Biochemistry 1996;35(33):10784-92.
1996: W A McGee; Federico I Rosell; J R Liggins; S Rodriguez-Ghidarpour; Y Luo; J Chen; Gary D Brayer; A Grant Mauk; Barry T Nall
Thermodynamic cycles as probes of structure in unfolded proteins.
Biochemistry 1996;35(6):1995-2007.
1995: C Braun; Gary D Brayer; Stephen G Withers
Mechanism-based inhibition of yeast alpha-glucosidase and human pancreatic alpha-amylase by a new class of inhibitors. 2-Deoxy-2,2-difluoro-alpha-glycosides.
The Journal of biological chemistry 1995;270(45):26778-81.
1995: Gary D Brayer; Y Luo; Stephen G Withers
The structure of human pancreatic alpha-amylase at 1.8 A resolution and comparisons with related enzymes.
Protein science : a publication of the Protein Society 1995;4(9):1730-42.
1995: R Bogumil; Robert Maurus; Dean P Hildebrand; Gary D Brayer; A Grant Mauk
Origin of the pH-dependent spectroscopic properties of pentacoordinate metmyoglobin variants.
Biochemistry 1995;34(33):10483-90.
1995: T P Lo; S Komar-Panicucci; Fred Sherman; George L McLendon; Gary D Brayer
Structural and functional effects of multiple mutations at distal sites in cytochrome c.
Biochemistry 1995;34(15):5259-68.
1995: Dean P Hildebrand; D L Burk; Robert Maurus; J C Ferrer; Gary D Brayer; A Grant Mauk
The proximal ligand variant His93Tyr of horse heart myoglobin.
Biochemistry 1995;34(6):1997-2005.
1995: T P Lo; M E Murphy; J Guy Guillemette; Michael Smith; Gary D Brayer
Replacements in a conserved leucine cluster in the hydrophobic heme pocket of cytochrome c.
Protein science : a publication of the Protein Society 1995;4(2):198-208.
1995: T P Lo; J Guy Guillemette; G V Louie; Michael Smith; Gary D Brayer
Structural studies of the roles of residues 82 and 85 at the interactive face of cytochrome c.
Biochemistry 1995;34(1):163-71.
1994: R Bogumil; C L Hunter; Robert Maurus; H L Tang; H Lee; E Lloyd; Gary D Brayer; Michael Smith; A Grant Mauk
FTIR analysis of the interaction of azide with horse heart myoglobin variants.
Biochemistry 1994;33(24):7600-8.
1994: S V Evans; B P Sishta; A Grant Mauk; Gary D Brayer
Three-dimensional structure of cyanomet-sulfmyoglobin C.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):4723-6.
1994: Robert Maurus; R Bogumil; Y Luo; H L Tang; Michael Smith; A Grant Mauk; Gary D Brayer
Structural characterization of heme ligation in the His64-->Tyr variant of myoglobin.
The Journal of biological chemistry 1994;269(17):12606-10.
1994: Albert Berghuis; J Guy Guillemette; George L McLendon; Fred Sherman; Michael Smith; Gary D Brayer
The role of a conserved internal water molecule and its associated hydrogen bond network in cytochrome c.
Journal of molecular biology 1994;236(3):786-99.
1994: Albert Berghuis; J Guy Guillemette; Michael Smith; Gary D Brayer
Mutation of tyrosine-67 to phenylalanine in cytochrome c significantly alters the local heme environment.
Journal of molecular biology 1994;235(4):1326-41.
1994: J Guy Guillemette; P D Barker; Lindsay D Eltis; T P Lo; Michael Smith; Gary D Brayer; A Grant Mauk
Analysis of the bimolecular reduction of ferricytochrome c by ferrocytochrome b5 through mutagenesis and molecular modelling.
Biochimie 1994;76(7):592-604.
1993: M E Murphy; J S Fetrow; R E Burton; Gary D Brayer
The structure and function of omega loop A replacements in cytochrome c.
Protein science : a publication of the Protein Society 1993;2(9):1429-40.
1993: D Burk; Y Wang; D Dombroski; Albert Berghuis; S V Evans; Y Luo; Stephen G Withers; Gary D Brayer
Isolation, crystallization and preliminary diffraction analyses of human pancreatic alpha-amylase.
Journal of molecular biology 1993;230(3):1084-5.
1993: C Schwab; A Twardek; T P Lo; Gary D Brayer; Hans Rudolf Bosshard
Mapping antibody binding sites on cytochrome c with synthetic peptides: are results representative of the antigenic structure of proteins?
Protein science : a publication of the Protein Society 1993;2(2):175-82.
1992: Y Wang; J Chen; Y Luo; W D Funk; Anne Mason; Robert C Woodworth; Ross T A MacGillivray; Gary D Brayer
Preliminary crystallographic analyses of the N-terminal lobe of recombinant human serum transferrin.
Journal of molecular biology 1992;227(2):575-6.
1992: M E Murphy; Barry T Nall; Gary D Brayer
Structure determination and analysis of yeast iso-2-cytochrome c and a composite mutant protein.
Journal of molecular biology 1992;227(1):160-76.
1992: R Langen; Gary D Brayer; Albert Berghuis; George L McLendon; Fred Sherman; Arieh Warshel
Effect of the Asn52----Ile mutation on the redox potential of yeast cytochrome c. Theory and experiment.
Journal of molecular biology 1992;224(3):589-600.
1992: Albert Berghuis; Gary D Brayer
Oxidation state-dependent conformational changes in cytochrome c.
Journal of molecular biology 1992;223(4):959-76.
1991: D R Hickey; Albert Berghuis; G Lafond; J A Jaeger; T S Cardillo; D McLendon; G Das; Fred Sherman; Gary D Brayer; George L McLendon
Enhanced thermodynamic stabilities of yeast iso-1-cytochromes c with amino acid replacements at positions 52 and 102.
The Journal of biological chemistry 1991;266(18):11686-94.
1990: G W Bushnell; G V Louie; Gary D Brayer
High-resolution three-dimensional structure of horse heart cytochrome c.
Journal of molecular biology 1990;214(2):585-95.
1990: G V Louie; Gary D Brayer
High-resolution refinement of yeast iso-1-cytochrome c and comparisons with other eukaryotic cytochromes c.
Journal of molecular biology 1990;214(2):527-55.
1990: S V Evans; Gary D Brayer
High-resolution study of the three-dimensional structure of horse heart metmyoglobin.
Journal of molecular biology 1990;213(4):885-97.
1990: W D Funk; T P Lo; Marcia R Mauk; Gary D Brayer; Ross T A MacGillivray; A Grant Mauk
Mutagenic, electrochemical, and crystallographic investigation of the cytochrome b5 oxidation-reduction equilibrium: involvement of asparagine-57, serine-64, and heme propionate-7.
Biochemistry 1990;29(23):5500-8.
1989: G V Louie; Gary D Brayer
A polypeptide chain-refolding event occurs in the Gly82 variant of yeast iso-1-cytochrome c.
Journal of molecular biology 1989;210(2):313-22.
1989: C J Leung; Barry T Nall; Gary D Brayer
Crystallization of yeast iso-2-cytochrome c using a novel hair seeding technique.
Journal of molecular biology 1989;206(4):783-5.
1989: V A Geddes; BF Le Bonniec; G V Louie; Gary D Brayer; A R Thompson; Ross T A MacGillivray
A moderate form of hemophilia B is caused by a novel mutation in the protease domain of factor IXVancouver.
The Journal of biological chemistry 1989;264(8):4689-97.
1988: G V Louie; G J Pielak; Michael Smith; Gary D Brayer
Role of phenylalanine-82 in yeast iso-1-cytochrome c and remote conformational changes induced by a serine residue at this position.
Biochemistry 1988;27(20):7870-6.
1988: E A Worobec; N L Martin; W D McCubbin; C M Kay; Gary D Brayer; Robert E W Hancock
Large-scale purification and biochemical characterization of crystallization-grade porin protein P from Pseudomonas aeruginosa.
Biochimica et biophysica acta 1988;939(2):366-74.
1988: S V Evans; Gary D Brayer
Horse heart metmyoglobin. A 2.8-A resolution three-dimensional structure determination.
The Journal of biological chemistry 1988;263(9):4263-8.
1988: G V Louie; W L Hutcheon; Gary D Brayer
Yeast iso-1-cytochrome c. A 2.8 A resolution three-dimensional structure determination.
Journal of molecular biology 1988;199(2):295-314.
1985: D E Cool; Cora-Jean S Edgell; G V Louie; M J Zoller; Gary D Brayer; Ross T A MacGillivray
Characterization of human blood coagulation factor XII cDNA. Prediction of the primary structure of factor XII and the tertiary structure of beta-factor XIIa.
The Journal of biological chemistry 1985;260(25):13666-76.