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Gareth Williams

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Joanne A Harrold; Gareth Williams
Melanocortin-4 receptors, beta-MSH and leptin: key elements in the satiety pathway.
Ebrahim K Naderali; sameer fatani; Gareth Williams
Fenofibrate lowers adiposity and corrects metabolic abnormalities, but only partially restores endothelial function in dietary obese rats.
Raphaël G. P. DENIS; C Bing; S Brocklehurst; Joanne A Harrold; Richard G Vernon; Gareth Williams
Diurnal changes in hypothalamic neuropeptide and SOCS-3 expression: effects of lactation and relationship with serum leptin and food intake.

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All Publications

2006: Joanne A Harrold; Gareth Williams
Melanocortin-4 receptors, beta-MSH and leptin: key elements in the satiety pathway.
Peptides 2006;27(2):365-71.
2004: Ebrahim K Naderali; sameer fatani; Gareth Williams
Fenofibrate lowers adiposity and corrects metabolic abnormalities, but only partially restores endothelial function in dietary obese rats.
Atherosclerosis 2004;177(2):307-12.
2004: Raphaël G. P. DENIS; C Bing; S Brocklehurst; Joanne A Harrold; Richard G Vernon; Gareth Williams
Diurnal changes in hypothalamic neuropeptide and SOCS-3 expression: effects of lactation and relationship with serum leptin and food intake.
The Journal of endocrinology 2004;183(1):173-81.
2004: Joanne C Elliott; Joanne A Harrold; Peter Brodin; Kerstin Enquist; Assar Bäckman; Mona Byström; Kerstin Lindgren; Peter King; Gareth Williams
Increases in melanin-concentrating hormone and MCH receptor levels in the hypothalamus of dietary-obese rats.
Brain research. Molecular brain research 2004;128(2):150-9.
2004: Gareth Williams; Xue J Cai; Joanne C Elliott; Joanne A Harrold
Anabolic neuropeptides.
Physiology & behavior 2004;81(2):211-22.
2004: Ebrahim K Naderali; sameer fatani; Gareth Williams
Chronic withdrawal of a high-palatable obesity-inducing diet completely reverses metabolic and vascular abnormalities associated with dietary-obesity in the rat.
Atherosclerosis 2004;172(1):63-9.
2003: Joanne A Harrold; Gareth Williams
The cannabinoid system: a role in both the homeostatic and hedonic control of eating?
The British journal of nutrition 2003;90(4):729-34.
2003: Ebrahim K Naderali; Debora Estadella; Milagros Rocha; Lucy C Pickavance; sameer fatani; Raphaël G. P. DENIS; Gareth Williams
A fat-enriched, glucose-enriched diet markedly attenuates adiponectin mRNA levels in rat epididymal adipose tissue.
Clinical science (London, England : 1979) 2003;105(4):403-8.
2003: Raphaël G. P. DENIS; C Bing; Ebrahim K Naderali; Richard G Vernon; Gareth Williams
Lactation modulates diurnal expression profiles of specific leptin receptor isoforms in the rat hypothalamus.
The Journal of endocrinology 2003;178(2):225-32.
2003: Lucy C Pickavance; Peter S Widdowson; John R Foster; Gareth Williams; John Wilding
Chronic treatment with the thiazolidinedione, MCC-555, is associated with reductions in nitric oxide synthase activity and beta-cell apoptosis in the pancreas of the Zucker Diabetic Fatty rat.
International journal of experimental pathology 2003;84(2):83-9.
2003: Joanne A Harrold; Peter S Widdowson; Gareth Williams
beta-MSH: a functional ligand that regulated energy homeostasis via hypothalamic MC4-R?
Peptides 2003;24(3):397-405.
2003: Raphaël G. P. DENIS; Gareth Williams; Richard G Vernon
Regulation of serum leptin and its role in the hyperphagia of lactation in the rat.
The Journal of endocrinology 2003;176(2):193-203.
2003: Steven J McNulty; Ehud Ur; Gareth Williams
A randomized trial of sibutramine in the management of obese type 2 diabetic patients treated with metformin.
Diabetes care 2003;26(1):125-31.
2002: Richard G Vernon; Raphaël G. P. DENIS; Annette Sorensen; Gareth Williams
Leptin and the adaptations of lactation in rodents and ruminants.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(11-12):678-85.
2002: J Gómez-Ambrosi; Natalia Zabalegui; Chen Bing; Michael J Tisdale; Paul Trayhurn; Gareth Williams
Weight loss in tumour-bearing mice is not associated with changes in resistin gene expression in white adipose tissue.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(11-12):674-7.
2002: Gareth Williams; Jim Waterhouse; J Mugarza; DS Minors; K Hayden
Therapy of circadian rhythm disorders in chronic fatigue syndrome: no symptomatic improvement with melatonin or phototherapy.
European journal of clinical investigation 2002;32(11):831-7.
2002: Sharon L Smith; Joanne A Harrold; Gareth Williams
Diet-induced obesity increases mu opioid receptor binding in specific regions of the rat brain.
Brain research 2002;953(1-2):215-22.
2002: Joanne A Harrold; Joanne C Elliott; Peter J King; Peter S Widdowson; Gareth Williams
Down-regulation of cannabinoid-1 (CB-1) receptors in specific extrahypothalamic regions of rats with dietary obesity: a role for endogenous cannabinoids in driving appetite for palatable food?
Brain research 2002;952(2):232-8.
2002: Chen Bing; Javier Gomez-Ambrosi; Natalia Zabalegui; Gareth Williams; Paul Trayhurn
Resistin and RELM-alpha gene expression in white adipose tissue of lactating mice.
Biochemical and biophysical research communications 2002;296(2):458-62.
2002: Jonathan H Pinkney; Gareth Williams
Ghrelin gets hungry.
Lancet 2002;359(9315):1360-1.
2002: Xue J Cai; Xiao H Liu; Martyn Evans; John Clapham; Shelagh Wilson; Jonathan R S Arch; Richard Morris; Gareth Williams
Orexins and feeding: special occasions or everyday occurrence?
Regulatory peptides 2002;104(1-3):1-9.
2002: C Bing; S T Russell; E E Beckett; P Collins; S Taylor; R Barraclough; M J Tisdale; Gareth Williams
Expression of uncoupling proteins-1, -2 and -3 mRNA is induced by an adenocarcinoma-derived lipid-mobilizing factor.
British journal of cancer 2002;86(4):612-8.
2002: Jonathan H Pinkney; John Wilding; Gareth Williams; Ian A MacFarlane
Hypothalamic obesity in humans: what do we know and what can be done?
Obesity reviews : an official journal of the International Association for the Study of Obesity 2002;3(1):27-34.
2001: Ebrahim K Naderali; Gareth Williams
Effects of short-term feeding of a highly palatable diet on vascular reactivity in rats.
European journal of clinical investigation 2001;31(12):1024-8.
2001: C Bing; S Taylor; M J Tisdale; Gareth Williams
Cachexia in MAC16 adenocarcinoma: suppression of hunger despite normal regulation of leptin, insulin and hypothalamic neuropeptide Y.
Journal of neurochemistry 2001;79(5):1004-12.
2001: Gareth Williams; C Bing; Xue J Cai; Joanne A Harrold; P J King; X H Liu
The hypothalamus and the control of energy homeostasis: different circuits, different purposes.
Physiology & behavior 2001;74(4-5):683-701.
2001: X H Liu; R Morris; D Spiller; M White; Gareth Williams
Orexin a preferentially excites glucose-sensitive neurons in the lateral hypothalamus of the rat in vitro.
Diabetes 2001;50(11):2431-7.
2001: Ebrahim K Naderali; M J Brown; Lucy C Pickavance; John Wilding; PJ Doyle; Gareth Williams
Dietary obesity in the rat induces endothelial dysfunction without causing insulin resistance: a possible role for triacylglycerols.
Clinical science (London, England : 1979) 2001;101(5):499-506.
2001: Ebrahim K Naderali; Lucy C Pickavance; John Wilding; Gareth Williams
Diet-induced endothelial dysfunction in the rat is independent of the degree of increase in total body weight.
Clinical science (London, England : 1979) 2001;100(6):635-41.
2001: Ebrahim K Naderali; Lucy C Pickavance; John Wilding; PJ Doyle; Gareth Williams
Troglitazone corrects metabolic changes but not vascular dysfunction in dietary-obese rats.
European journal of pharmacology 2001;416(1-2):133-9.
2001: Xue J Cai; Raphaël G. P. DENIS; R G Vernon; John Clapham; Shelagh Wilson; Jonathan R S Arch; Gareth Williams
Food restriction selectively increases hypothalamic orexin-B levels in lactating rats.
Regulatory peptides 2001;97(2-3):163-8.
2001: Ebrahim K Naderali; S L Smith; PJ Doyle; Gareth Williams
Vasorelaxant effects of oestradiols on guinea pigs: a role for gender differences.
European journal of clinical investigation 2001;31(3):215-20.
2001: P Collins; Gareth Williams
Drug treatment of obesity: from past failures to future successes?
British journal of clinical pharmacology 2001;51(1):13-25.
2001: Xue J Cai; M L Evans; Carolyn A Lister; Ronald A Leslie; Jonathan R S Arch; Shelagh Wilson; Gareth Williams
Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels: responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract.
Diabetes 2001;50(1):105-12.
2001: Ebrahim K Naderali; S L Smith; PJ Doyle; Gareth Williams
The mechanism of resveratrol-induced vasorelaxation differs in the mesenteric resistance arteries of lean and obese rats.
Clinical science (London, England : 1979) 2001;100(1):55-60.
2000: Gareth Williams; J A Harrold; D J Cutler
The hypothalamus and the regulation of energy homeostasis: lifting the lid on a black box.
The Proceedings of the Nutrition Society 2000;59(3):385-96.
2000: Joanne A Harrold; Peter S Widdowson; John Clapham; Gareth Williams
Individual severity of dietary obesity in unselected Wistar rats: relationship with hyperphagia.
American journal of physiology. Endocrinology and metabolism 2000;279(2):E340-7.
2000: P J King; Gareth Williams; HN Doods; Peter S Widdowson
Effect of a selective neuropeptide Y Y(2) receptor antagonist, BIIE0246 on neuropeptide Y release.
European journal of pharmacology 2000;396(1):R1-3.
2000: Chen Bing; M Brown; P King; P Collins; Michael J Tisdale; Gareth Williams
Increased gene expression of brown fat uncoupling protein (UCP)1 and skeletal muscle UCP2 and UCP3 in MAC16-induced cancer cachexia.
Cancer research 2000;60(9):2405-10.
2000: Ebrahim K Naderali; PJ Doyle; Gareth Williams
Resveratrol induces vasorelaxation of mesenteric and uterine arteries from female guinea-pigs.
Clinical science (London, England : 1979) 2000;98(5):537-43.
2000: Xue J Cai; Carolyn A Lister; RE Buckingham; Lucy C Pickavance; J Wilding; Jonathan R S Arch; Shelagh Wilson; Gareth Williams
Down-regulation of orexin gene expression by severe obesity in the rats: studies in Zucker fatty and zucker diabetic fatty rats and effects of rosiglitazone.
Brain research. Molecular brain research 2000;77(1):131-7.
2000: Joanne A Harrold; Gareth Williams; Peter S Widdowson
Early leptin response to a palatable diet predicts dietary obesity in rats: key role of melanocortin-4 receptors in the ventromedial hypothalamic nucleus.
Journal of neurochemistry 2000;74(3):1224-8.
2000: P J King; Peter S Widdowson; HN Doods; Gareth Williams
Effect of cytokines on hypothalamic neuropeptide Y release in vitro.
Peptides 2000;21(1):143-6.
2000: P J King; Peter S Widdowson; HN Doods; Gareth Williams
Regulation of neuropeptide Y release from hypothalamic slices by melanocortin-4 agonists and leptin.
Peptides 2000;21(1):45-8.
1999: D J Cutler; R Morris; V Sheridhar; T A Wattam; S Holmes; S Patel; Jonathan R S Arch; S Wilson; RE Buckingham; M L Evans; Ronald A Leslie; Gareth Williams
Differential distribution of orexin-A and orexin-B immunoreactivity in the rat brain and spinal cord.
Peptides 1999;20(12):1455-70.
1999: Ebrahim K Naderali; AB Walker; P Doyle; Gareth Williams
Comparable vasorelaxant effects of 17alpha- and 17beta-oestradiol on rat mesenteric resistance arteries: an action independent of the oestrogen receptor.
Clinical science (London, England : 1979) 1999;97(6):649-55.
1999: S Park; Joanne A Harrold; Peter S Widdowson; Gareth Williams
Increased binding at 5-HT(1A), 5-HT(1B), and 5-HT(2A) receptors and 5-HT transporters in diet-induced obese rats.
Brain research 1999;847(1):90-7.
1999: Xue J Cai; Peter S Widdowson; Joanne A Harrold; Shelagh Wilson; RE Buckingham; Jonathan R S Arch; Moh Tadayyon; John Clapham; J Wilding; Gareth Williams
Hypothalamic orexin expression: modulation by blood glucose and feeding.
Diabetes 1999;48(11):2132-7.
1999: P J King; Peter S Widdowson; HN Doods; Gareth Williams
Regulation of neuropeptide Y release by neuropeptide Y receptor ligands and calcium channel antagonists in hypothalamic slices.
Journal of neurochemistry 1999;73(2):641-6.
1999: AB Walker; P D Chattington; RE Buckingham; Gareth Williams
The thiazolidinedione rosiglitazone (BRL-49653) lowers blood pressure and protects against impairment of endothelial function in Zucker fatty rats.
Diabetes 1999;48(7):1448-53.
1999: Gareth Williams
Obesity and type 2 diabetes: a conflict of interests?
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1999;23 Suppl 7():S2-4.
1999: S Dryden; M Brown; P King; Gareth Williams
Decreased plasma leptin levels in lean and obese Zucker rats after treatment with the serotonin reuptake inhibitor fluoxetine.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1999;31(6):363-6.
1999: Joanne A Harrold; Gareth Williams; Peter S Widdowson
Changes in hypothalamic agouti-related protein (AGRP), but not alpha-MSH or pro-opiomelanocortin concentrations in dietary-obese and food-restricted rats.
Biochemical and biophysical research communications 1999;258(3):574-7.
1999: Chen Bing; P King; Lucy C Pickavance; M Brown; D Ziegler; E Kaan; Gareth Williams
The effect of moxonidine on feeding and body fat in obese Zucker rats: role of hypothalamic NPY neurones.
British journal of pharmacology 1999;127(1):35-42.
1999: S Dryden; P King; Lucy C Pickavance; P Doyle; Gareth Williams
Divergent effects of intracerebroventricular and peripheral leptin administration on feeding and hypothalamic neuropeptide Y in lean and obese (fa/fa) Zucker rats.
Clinical science (London, England : 1979) 1999;96(3):307-12.
1999: Joanne A Harrold; Peter S Widdowson; Gareth Williams
Altered energy balance causes selective changes in melanocortin-4(MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding.
Diabetes 1999;48(2):267-71.
1999: Lucy C Pickavance; Peter S Widdowson; R G Vernon; Gareth Williams
Neuropeptide Y receptor alterations in the hypothalamus of lactating rats.
Peptides 1999;20(9):1055-60.
1999: Peter S Widdowson; L Henderson; Lucy C Pickavance; RE Buckingham; Moh Tadayyon; Jonathan R S Arch; Gareth Williams
Hypothalamic NPY status during positive energy balance and the effects of the NPY antagonist, BW 1229U91, on the consumption of highly palatable energy-rich diet.
Peptides 1999;20(3):367-72.
1998: R Upton; Peter S Widdowson; S Ishii; H Tanaka; Gareth Williams
Improved metabolic status and insulin sensitivity in obese fatty (fa/fa) Zucker rats and Zucker Diabetic Fatty (ZDF) rats treated with the thiazolidinedione, MCC-555.
British journal of pharmacology 1998;125(8):1708-14.
1998: Lucy C Pickavance; Peter S Widdowson; P King; S Ishii; H Tanaka; Gareth Williams
The development of overt diabetes in young Zucker Diabetic Fatty (ZDF) rats and the effects of chronic MCC-555 treatment.
British journal of pharmacology 1998;125(4):767-70.
1998: Lucy C Pickavance; Moh Tadayyon; Gareth Williams; R G Vernon
Lactation suppresses diurnal rhythm of serum leptin.
Biochemical and biophysical research communications 1998;248(1):196-9.
1998: MW Savage; V Mohamed-Ali; Gareth Williams
Suppression of post-glucose hyperinsulinaemia does not affect blood pressure in either normotensive or hypertensive subjects.
Clinical science (London, England : 1979) 1998;94(6):609-14.
1998: Peter S Widdowson; R Upton; Lucy C Pickavance; RE Buckingham; Moh Tadayyon; Jonathan R S Arch; Gareth Williams
Acute hyperleptinemia does not modify insulin sensitivity in vivo in the rat.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1998;30(5):259-62.
1998: AB Walker; Ebrahim K Naderali; P D Chattington; RE Buckingham; Gareth Williams
Differential vasoactive effects of the insulin sensitizers rosiglitazone (BRL 49653) and troglitazone on human small arteries in vitro.
Diabetes 1998;47(5):810-4.
1998: S Dryden; Lucy C Pickavance; D Tidd; Gareth Williams
The lack of specificity of neuropeptide Y (NPY) antisense oligodeoxynucleotides administered intracerebroventricularly in inhibiting food intake and NPY gene expression in the rat hypothalamus.
The Journal of endocrinology 1998;157(1):169-75.
1998: S Dryden; Lucy C Pickavance; L Henderson; Gareth Williams
Hyperphagia induced by hypoglycemia in rats is independent of leptin and hypothalamic neuropeptide Y (NPY).
Peptides 1998;19(9):1549-55.
1998: Chen Bing; HM Frankish; Lucy C Pickavance; Q Wang; D F Hopkins; M J Stock; Gareth Williams
Hyperphagia in cold-exposed rats is accompanied by decreased plasma leptin but unchanged hypothalamic NPY.
The American journal of physiology 1998;274(1 Pt 2):R62-8.
1998: Chen Bing; D Hopkins; Q Wang; HM Frankish; RE Buckingham; Gareth Williams
Direct stimulation of BAT thermogenesis does not affect hypothalamic neuropeptide Y.
Peptides 1998;19(1):167-70.
1997: S Dryden; S J Burns; HM Frankish; Gareth Williams
Increased hypothalamic neuropeptide Y concentration or hyperphagia in streptozotocin-diabetic rats are not mediated by glucocorticoids.
European journal of pharmacology 1997;340(2-3):221-5.
1997: Peter S Widdowson; RE Buckingham; Gareth Williams
Distribution of [Leu31,Pro34]NPY-sensitive, BIBP3226-insensitive [125I]PYY(3-36) binding sites in rat brain: possible relationship to Y5 NPY receptors.
Brain research 1997;778(1):242-50.
1997: D F Hopkins; Gareth Williams
Insulin receptors are widely distributed in human brain and bind human and porcine insulin with equal affinity.
Diabetic medicine : a journal of the British Diabetic Association 1997;14(12):1044-50.
1997: Q Wang; S Dryden; HM Frankish; Chen Bing; Lucy C Pickavance; D Hopkins; RE Buckingham; Gareth Williams
Increased feeding in fatty Zucker rats by the thiazolidinedione BRL 49653 (rosiglitazone) and the possible involvement of leptin and hypothalamic neuropeptide Y.
British journal of pharmacology 1997;122(7):1405-10.
1997: Peter S Widdowson; R Upton; L Henderson; RE Buckingham; S Wilson; Gareth Williams
Reciprocal regional changes in brain NPY receptor density during dietary restriction and dietary-induced obesity in the rat.
Brain research 1997;774(1-2):1-10.
1997: Peter S Widdowson; R Upton; RE Buckingham; Jonathan R S Arch; Gareth Williams
Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity.
Diabetes 1997;46(11):1782-5.
1997: AB Walker; J Dores; RE Buckingham; MW Savage; Gareth Williams
Impaired insulin-induced attenuation of noradrenaline-mediated vasoconstriction in insulin-resistant obese Zucker rats.
Clinical science (London, England : 1979) 1997;93(3):235-41.
1997: Chen Bing; Lucy C Pickavance; Q Wang; HM Frankish; Paul Trayhurn; Gareth Williams
Role of hypothalamic neuropeptide Y neurons in the defective thermogenic response to acute cold exposure in fatty Zucker rats.
Neuroscience 1997;80(1):277-84.
1997: Q Wang; Chen Bing; Kamal A Al-Barazanji; D E Mossakowaska; X M Wang; DL McBay; W A Neville; M Taddayon; Lucy C Pickavance; S Dryden; M E Thomas; M T McHale; I S Gloyer; S Wilson; RE Buckingham; Jonathan R S Arch; Paul Trayhurn; Gareth Williams
Interactions between leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis in the rat.
Diabetes 1997;46(3):335-41.
1997: AB Walker; MW Savage; J Dores; Gareth Williams
Insulin-induced attenuation of noradrenaline-mediated vasoconstriction in resistance arteries from Wistar rats is nitric oxide dependent.
Clinical science (London, England : 1979) 1997;92(2):147-52.
1996: Gareth Williams; J Pirmohamed; D Minors; J Waterhouse; I Buchan; J Arendt; R H Edwards
Dissociation of body-temperature and melatonin secretion circadian rhythms in patients with chronic fatigue syndrome.
Clinical physiology (Oxford, England) 1996;16(4):327-37.
1996: S Dryden; HM Frankish; Q Wang; Gareth Williams
Increased feeding and neuropeptide Y (NPY) but not NPY mRNA levels in the hypothalamus of the rat following central administration of the serotonin synthesis inhibitor p-chlorophenylalanine.
Brain research 1996;724(2):232-7.
1996: S Dryden; HM Frankish; Q Wang; Lucy C Pickavance; Gareth Williams
The serotonergic agent fluoxetine reduces neuropeptide Y levels and neuropeptide Y secretion in the hypothalamus of lean and obese rats.
Neuroscience 1996;72(2):557-66.
1996: Lucy C Pickavance; S Dryden; D Hopkins; Chen Bing; HM Frankish; Q Wang; R G Vernon; Gareth Williams
Relationships between hypothalamic neuropeptide Y and food intake in the lactating rat.
Biochemical Society transactions 1996;24(2):236S.
1996: Chen Bing; W Wang; Lucy C Pickavance; Gareth Williams
The central regulation of energy homeostasis: roles of neuropeptide Y and other brain peptides.
Biochemical Society transactions 1996;24(2):559-65.
1996: G Leese; P Chattington; W Fraser; J Vora; R Edwards; Gareth Williams
Short-term night-shift working mimics the pituitary-adrenocortical dysfunction in chronic fatigue syndrome.
The Journal of clinical endocrinology and metabolism 1996;81(5):1867-70.
1996: S Dryden; Q Wang; HM Frankish; Gareth Williams
Differential effects of the 5-HT 1B/2C receptor agonist mCPP and the 5-HT1A agonist flesinoxan on hypothalamic neuropeptide Y in the rat: evidence that NPY may mediate serotonin's effects on food intake.
Peptides 1996;17(6):943-9.
1996: A Tomaszuk; C Simpson; Gareth Williams
Neuropeptide Y, the hypothalamus and the regulation of energy homeostasis.
Hormone research 1996;46(2):53-8.
1996: Lucy C Pickavance; S Dryden; D Hopkins; Chen Bing; HM Frankish; Q Wang; R G Vernon; Gareth Williams
Relationships between hypothalamic neuropeptide Y and food intake in the lactating rat.
Peptides 1996;17(4):577-82.
1996: Chen Bing; HM Frankish; Q Wang; D Hopkins; J Keith; Paul Trayhurn; Gareth Williams
Dissociation of hypothalamic NPY from BAT uncoupling protein mRNA in rats exposed to 24 h thermoneutrality.
The American journal of physiology 1996;270(1 Pt 2):R111-7.
1995: M W Savage; C W Bodmer; AB Walker; I E Buchan; E A Masson; Gareth Williams
Vascular reactivity to noradrenaline and neuropeptide Y in the streptozotocin-induced diabetic rat.
European journal of clinical investigation 1995;25(12):974-9.
1995: S Dryden; Q Wang; HM Frankish; Lucy C Pickavance; Gareth Williams
The serotonin (5-HT) antagonist methysergide increases neuropeptide Y (NPY) synthesis and secretion in the hypothalamus of the rat.
Brain research 1995;699(1):12-8.
1995: H D McCarthy; S Dryden; Gareth Williams
Interleukin-1 beta-induced anorexia and pyrexia in rat: relationship to hypothalamic neuropeptide Y.
The American journal of physiology 1995;269(5 Pt 1):E852-7.
1995: HM Frankish; S Dryden; Q Wang; Chen Bing; I A MacFarlane; Gareth Williams
Nicotine administration reduces neuropeptide Y and neuropeptide Y mRNA concentrations in the rat hypothalamus: NPY may mediate nicotine's effects on energy balance.
Brain research 1995;694(1-2):139-46.
1995: S Dryden; Lucy C Pickavance; HM Frankish; Gareth Williams
Increased neuropeptide Y secretion in the hypothalamic paraventricular nucleus of obese (fa/fa) Zucker rats.
Brain research 1995;690(2):185-8.
1995: C W Bodmer; N C Schaper; M Janssen; P W De Leeuw; Gareth Williams
Selective enhancement of alpha 2-adrenoceptor-mediated vasoconstriction in insulin-dependent diabetic patients with microalbuminuria.
Clinical science (London, England : 1979) 1995;88(4):421-6.
1995: I Cusin; S Dryden; Q Wang; Françoise Rohner-Jeanrenaud; B Jeanrenaud; Gareth Williams
Effect of sustained physiological hyperinsulinaemia on hypothalamic neuropeptide Y and NPY mRNA levels in the rat.
Journal of neuroendocrinology 1995;7(3):193-7.
1995: SJ Benbow; D W Pryce; K Noblett; Ian A MacFarlane; Peter S Friedmann; Gareth Williams
Flow motion in peripheral diabetic neuropathy.
Clinical science (London, England : 1979) 1995;88(2):191-6.
1995: HM Frankish; S Dryden; D Hopkins; Q Wang; Gareth Williams
Neuropeptide Y, the hypothalamus, and diabetes: insights into the central control of metabolism.
Peptides 1995;16(4):757-71.
1994: H D McCarthy; R E Crowder; S Dryden; Gareth Williams
Megestrol acetate stimulates food and water intake in the rat: effects on regional hypothalamic neuropeptide Y concentrations.
European journal of pharmacology 1994;265(1-2):99-102.
1994: C W Bodmer; E A Masson; M W Savage; SJ Benbow; A W Patrick; Gareth Williams
Asymptomatic peripheral nerve dysfunction and vascular reactivity in IDDM patients with and without microalbuminuria.
Diabetologia 1994;37(10):1056-61.
1994: SJ Benbow; A W Chan; D R Bowsher; Gareth Williams; Ian A MacFarlane
The prediction of diabetic neuropathic plantar foot ulceration by liquid-crystal contact thermography.
Diabetes care 1994;17(8):835-9.
1994: C W Bodmer; D T Valentine; E A Masson; M W Savage; D Lake; Gareth Williams
Smoking attenuates the vasoconstrictor response to noradrenaline in type I diabetic patients and normal subjects: possible relevance to diabetic nephropathy.
European journal of clinical investigation 1994;24(5):331-6.
1994: S Dryden; HM Frankish; Q Wang; Gareth Williams
Neuropeptide Y and energy balance: one way ahead for the treatment of obesity?
European journal of clinical investigation 1994;24(5):293-308.
1994: Gareth Williams
IDDM: long honeymoon, sweet ending.
Lancet 1994;343(8899):684-5.
1994: R Arora; S Dryden; P E McKibbin; Gareth Williams
Acute dexfenfluramine administration normalizes glucose tolerance in rats with insulin-deficient diabetes.
European journal of clinical investigation 1994;24(3):182-7.
1994: Gareth Williams
Management of non-insulin-dependent diabetes mellitus.
Lancet 1994;343(8889):95-100.
1994: U H Malabu; S Dryden; H D McCarthy; A Kilpatrick; Gareth Williams
Effects of chronic vanadate administration in the STZ-induced diabetic rat. The antihyperglycemic action of vanadate is attributable entirely to its suppression of feeding.
Diabetes 1994;43(1):9-15.
1994: SJ Benbow; A W Chan; D Bowsher; Ian A MacFarlane; Gareth Williams
A prospective study of painful symptoms, small-fibre function and peripheral vascular disease in chronic painful diabetic neuropathy.
Diabetic medicine : a journal of the British Diabetic Association 1994;11(1):17-21.
1994: U H Malabu; A Kilpatrick; M Ware; R G Vernon; Gareth Williams
Increased neuropeptide Y concentrations in specific hypothalamic regions of lactating rats: possible relationship to hyperphagia and adaptive changes in energy balance.
Peptides 1994;15(1):83-7.
1993: M W Savage; William D Fraser; C W Bodmer; A F Ginty; James A Gallagher; J Robinson; Gareth Williams
Hypercalcaemia due to parathyroid hormone-related protein: long-term circulating levels may not reflect tumour activity.
Clinical endocrinology 1993;39(6):695-8; discussion 699.
1993: HM Frankish; H D McCarthy; S Dryden; A Kilpatrick; Gareth Williams
Neuropeptide Y receptor numbers are reduced in the hypothalamus of streptozotocin-diabetic and food-deprived rats: further evidence of increased activity of hypothalamic NPY-containing pathways.
Peptides 1993;14(5):941-8.
1993: K L Tieszen; A W Patrick; E Smith; Gareth Williams; T L Dornan
Accurate and precise blood glucose measurement in the hypoglycaemic range.
Diabetic medicine : a journal of the British Diabetic Association 1993;10(6):560-3.
1993: D F Hopkins; S J Cotton; Gareth Williams
Effective treatment of insulin-induced edema using ephedrine.
Diabetes care 1993;16(7):1026-8.
1993: S Dryden; H D McCarthy; U H Malabu; M Ware; Gareth Williams
Increased neuropeptide Y concentrations in specific hypothalamic nuclei of the rat following treatment with methysergide: evidence that NPY may mediate serotonin's effects on food intake.
Peptides 1993;14(4):791-6.
1993: H D McCarthy; A P Kilpatrick; Paul Trayhurn; Gareth Williams
Widespread increases in regional hypothalamic neuropeptide Y levels in acute cold-exposed rats.
Neuroscience 1993;54(1):127-32.
1993: H D McCarthy; P E McKibbin; A V Perkins; E A Linton; Gareth Williams
Alterations in hypothalamic NPY and CRF in anorexic tumor-bearing rats.
The American journal of physiology 1993;264(4 Pt 1):E638-43.
1993: D E Lewis; L Shellard; D G Koeslag; D E Boer; H D McCarthy; P E McKibbin; J C Russell; Gareth Williams
Intense exercise and food restriction cause similar hypothalamic neuropeptide Y increases in rats.
The American journal of physiology 1993;264(2 Pt 1):E279-84.
1993: U H Malabu; S J Cotton; Y T Kruszynska; Gareth Williams
Acute hyperinsulinemia increases neuropeptide Y concentrations in the hypothalamic arcuate nucleus of fasted rats.
Life sciences 1993;52(17):1407-16.
1992: U H Malabu; H D McCarthy; P E McKibbin; Gareth Williams
Peripheral insulin administration attenuates the increase in neuropeptide Y concentrations in the hypothalamic arcuate nucleus of fasted rats.
Peptides 1992;13(6):1097-102.
1992: P E McKibbin; H D McCarthy; P Shaw; Gareth Williams
Insulin deficiency is a specific stimulus to hypothalamic neuropeptide Y: a comparison of the effects of insulin replacement and food restriction in streptozocin-diabetic rats.
Peptides 1992;13(4):721-7.
1992: K L Simmons; Gareth Williams
Attempts to accelerate glucagon absorption: effects of adding a vasodilator and of injection using a 'sprinkler' needle.
European journal of clinical investigation 1992;22(6):434-7.
1992: Gareth Williams; L Shellard; D E Lewis; P E McKibbin; H D McCarthy; D G Koeslag; J C Russell
Hypothalamic neuropeptide Y disturbances in the obese (cp/cp) JCR:LA corpulent rat.
Peptides 1992;13(3):537-40.
1992: C W Bodmer; A W Patrick; T V How; Gareth Williams
Exaggerated sensitivity to NE-induced vasoconstriction in IDDM patients with microalbuminuria. Possible etiology and diagnostic implications.
Diabetes 1992;41(2):209-14.
1992: P E McKibbin; S J Cotton; H D McCarthy; Gareth Williams
The effect of dexamethasone on neuropeptide Y concentrations in specific hypothalamic regions.
Life sciences 1992;51(16):1301-7.
1991: Gareth Williams; P E McKibbin; H D McCarthy
Hypothalamic regulatory peptides and the regulation of food intake and energy balance: signals or noise?
The Proceedings of the Nutrition Society 1991;50(3):527-44.
1991: P E McKibbin; S J Cotton; S McMillan; B Holloway; R Mayers; H D McCarthy; Gareth Williams
Altered neuropeptide Y concentrations in specific hypothalamic regions of obese (fa/fa) Zucker rats. Possible relationship to obesity and neuroendocrine disturbances.
Diabetes 1991;40(11):1423-9.
1991: A W Patrick; C W Bodmer; K L Tieszen; M C White; Gareth Williams
Human insulin and awareness of acute hypoglycaemic symptoms in insulin-dependent diabetes.
Lancet 1991;338(8766):528-32.
1991: S E Corrin; H D McCarthy; P E McKibbin; Gareth Williams
Unchanged hypothalamic neuropeptide Y concentrations in hyperphagic, hypoglycemic rats: evidence for specific metabolic regulation of hypothalamic NPY.
Peptides 1991;12(3):425-30.
1991: P Rogers; P E McKibbin; Gareth Williams
Acute fenfluramine administration reduces neuropeptide Y concentrations in specific hypothalamic regions of the rat: possible implications for the anorectic effect of fenfluramine.
Peptides 1991;12(2):251-5.
1991: P E McKibbin; P Rogers; Gareth Williams
Increased neuropeptide Y concentrations in the lateral hypothalamic area of the rat after the onset of darkness: possible relevance to the circadian periodicity of feeding behavior.
Life sciences 1991;48(26):2527-33.
1991: H D McCarthy; P E McKibbin; B Holloway; R Mayers; Gareth Williams
Hypothalamic neuropeptide Y receptor characteristics and NPY-induced feeding responses in lean and obese Zucker rats.
Life sciences 1991;49(20):1491-7.
1989: Gareth Williams; S R Bloom
Regulatory peptides, the hypothalamus and diabetes.
Diabetic medicine : a journal of the British Diabetic Association 1989;6(6):472-85.