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Graham Williams

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TOP 3
Anna Wojcicka; J H Duncan Bassett; Graham R Williams
Mechanisms of action of thyroid hormones in the skeleton.
Antonia Hoeg; Josef Köhrle; Sandra Mueller; Elaine Murphy; David M Reid; Christian Roux; Lutz Schomburg; Richard Eastell; Dieter Felsenberg; Claus C Glüer; Apostolos Gogakos; Graham R Williams
Bone turnover and bone mineral density are independently related to selenium status in healthy euthyroid postmenopausal women.
Jonathan J Nicholls; Graham R Williams; Mary Jane Brassill; J H Duncan Bassett
The skeletal consequences of thyrotoxicosis.

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All Publications

2013: Anna Wojcicka; J H Duncan Bassett; Graham R Williams
Mechanisms of action of thyroid hormones in the skeleton.
Biochimica et biophysica acta 2013;1830(7):3979-86.
2012: Antonia Hoeg; Josef Köhrle; Sandra Mueller; Elaine Murphy; David M Reid; Christian Roux; Lutz Schomburg; Richard Eastell; Dieter Felsenberg; Claus C Glüer; Apostolos Gogakos; Graham R Williams
Bone turnover and bone mineral density are independently related to selenium status in healthy euthyroid postmenopausal women.
The Journal of clinical endocrinology and metabolism 2012;97(11):4061-70.
2012: Jonathan J Nicholls; Graham R Williams; Mary Jane Brassill; J H Duncan Bassett
The skeletal consequences of thyrotoxicosis.
The Journal of endocrinology 2012;213(3):209-21.
2012: Julian A Waung; J H Duncan Bassett; Graham R Williams
Thyroid hormone metabolism in skeletal development and adult bone maintenance.
Trends in endocrinology and metabolism: TEM 2012;23(4):155-62.
2012: J H Duncan Bassett; Alan Boyde; Michael J Campbell; Peter I Croucher; Holly Evans; Apostolos Gogakos; Richard M Jacques; Ramiro Ramirez-Solis; Edward Ryder; David Sunter; Anne H van der Spek; Jacqueline K White; Graham R Williams
Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength.
PLoS genetics 2012;8(8):e1002858.
2012: J H Duncan Bassett; Apostolos Gogakos; Anne van der Spek; Graham R Williams
Quantitative X-ray imaging of rodent bone by Faxitron.
Methods in molecular biology (Clifton, N.J.) 2012;816():499-506.
2011: Graham R Williams; J H Duncan Bassett
Deiodinases: the balance of thyroid hormone: local control of thyroid hormone action: role of type 2 deiodinase.
The Journal of endocrinology 2011;209(3):261-72.
2011: C E Combs; J J Nicholls; J H Duncan Bassett; Graham R Williams
Thyroid hormones and bone development.
Minerva endocrinologica 2011;36(1):71-85.
2011: Maximilien Vanleene; Zahraa Saldanha; Kristy L Cloyd; Gavin Jell; George Bou-Gharios; J H Duncan Bassett; Graham R Williams; Nicholas M Fisk; Michelle L Oyen; Molly M Stevens; Pascale V Guillot; Sandra J Shefelbine
Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties.
Blood 2011;117(3):1053-60.
2010: Apostolos I Gogakos; J H Duncan Bassett; Graham R Williams
Thyroid and bone.
Archives of biochemistry and biophysics 2010;503(1):129-36.
2009: J H Duncan Bassett; Graham R Williams
The skeletal phenotypes of TRalpha and TRbeta mutant mice.
Journal of molecular endocrinology 2009;42(4):269-82.
2009: Tricia M-M Tan; Carmela Caputo; Francesco Medici; Alidz L Pambakian; Anne Dornhorst; Karim Meeran; Graham R Williams; Bernard Khoo
MELAS syndrome, diabetes and thyroid disease: the role of mitochondrial oxidative stress.
Clinical endocrinology 2009;70(2):340-1.
2008: J H Duncan Bassett; Graham R Williams
Critical role of the hypothalamic-pituitary-thyroid axis in bone.
Bone 2008;43(3):418-26.
2008: Allan J Williams; Helen Robson; Monique H A Kester; Johannes P T M van Leeuwen; Stephen M Shalet; Theo J Visser; Graham R Williams
Iodothyronine deiodinase enzyme activities in bone.
Bone 2008;43(1):126-34.
2008: Graham R Williams
Neurodevelopmental and neurophysiological actions of thyroid hormone.
Journal of neuroendocrinology 2008;20(6):784-94.
2008: Pascale V Guillot; Oyebode Abass; J H Duncan Bassett; Sandra J Shefelbine; George Bou-Gharios; Jerry Chan; Hitoshi Kurata; Graham R Williams; Julia Polak; Nicholas M Fisk
Intrauterine transplantation of human fetal mesenchymal stem cells from first-trimester blood repairs bone and reduces fractures in osteogenesis imperfecta mice.
Blood 2008;111(3):1717-25.
2008: J H Duncan Bassett; Allan J Williams; Elaine Murphy; Alan Boyde; Peter G T Howell; Rowan Swinhoe; Marta Archanco; Frédéric Flamant; Jacques Samarut; Sabine Costagliola; Gilbert Vassart; Roy E Weiss; Samuel Refetoff; Graham R Williams
A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism.
Molecular endocrinology (Baltimore, Md.) 2008;22(2):501-12.
2007: Allan J Williams; Patrick J O'Shea; Graham R Williams
Complex interactions between thyroid hormone and fibroblast growth factor signalling.
Current opinion in endocrinology, diabetes, and obesity 2007;14(5):410-5.
2007: J H Duncan Bassett; Kristina Nordström; Alan Boyde; Peter G T Howell; Shane Kelly; Björn Vennström; Graham R Williams
Thyroid status during skeletal development determines adult bone structure and mineralization.
Molecular endocrinology (Baltimore, Md.) 2007;21(8):1893-904.
2007: Graham R Williams
Hypogonadal bone loss: sex steroids or gonadotropins?
Endocrinology 2007;148(6):2610-2.
2007: J H Duncan Bassett; Patrick J O'Shea; Srividya Sriskantharajah; Bénédicte Rabier; Alan Boyde; Peter G T Howell; Roy E Weiss; Jean-Paul Roux; Luc Malaval; Phillipe Clement-Lacroix; Jacques Samarut; Olivier Chassande; Graham R Williams
Thyroid hormone excess rather than thyrotropin deficiency induces osteoporosis in hyperthyroidism.
Molecular endocrinology (Baltimore, Md.) 2007;21(5):1095-107.
2007: Clare B Harvey; J H Duncan Bassett; Padma Maruvada; Paul M Yen; Graham R Williams
The rat thyroid hormone receptor (TR) Deltabeta3 displays cell-, TR isoform-, and thyroid hormone response element-specific actions.
Endocrinology 2007;148(4):1764-73.
2006: Bénédicte Rabier; Allan J Williams; Frederic Mallein-Gerin; Graham R Williams; Olivier Chassande
Thyroid hormone-stimulated differentiation of primary rib chondrocytes in vitro requires thyroid hormone receptor beta.
The Journal of endocrinology 2006;191(1):221-8.
2006: Elaine Murphy; J H Duncan Bassett; Graham R Williams
Disorders of calcium metabolism.
The Practitioner 2006;250(1686):4-6, 8.
2006: Patrick J O'Shea; J H Duncan Bassett; Sheue-Yann Cheng; Graham R Williams
Characterization of skeletal phenotypes of TRalpha1 and TRbeta mutant mice: implications for tissue thyroid status and T3 target gene expression.
Nuclear receptor signaling 2006;4():e011.
2006: J H Duncan Bassett; R Swinhoe; Olivier Chassande; Jacques Samarut; Graham R Williams
Thyroid hormone regulates heparan sulfate proteoglycan expression in the growth plate.
Endocrinology 2006;147(1):295-305.
2005: T M Galliford; E Murphy; Allan J Williams; J H Duncan Bassett; Graham R Williams
Effects of thyroid status on bone metabolism: a primary role for thyroid stimulating hormone or thyroid hormone?
Minerva endocrinologica 2005;30(4):237-46.
2005: Joanna C Barnard; Allan J Williams; Bénédicte Rabier; Olivier Chassande; Jacques Samarut; Sheue-Yann Cheng; J H Duncan Bassett; Graham R Williams
Thyroid hormones regulate fibroblast growth factor receptor signaling during chondrogenesis.
Endocrinology 2005;146(12):5568-80.
2005: Patrick J O'Shea; J H Duncan Bassett; Srividya Sriskantharajah; Hao Ying; Sheue-Yann Cheng; Graham R Williams
Contrasting skeletal phenotypes in mice with an identical mutation targeted to thyroid hormone receptor alpha1 or beta.
Molecular endocrinology (Baltimore, Md.) 2005;19(12):3045-59.
2004: Maha T Barakat; Houman Ashrafian; Jeannie F Todd; Karim Meeran; Graham R Williams
Severe hypercalcaemia from secretion of parathyroid hormone-related peptide.
The lancet oncology 2004;5(10):633-5.
2004: Elaine Murphy; Graham R Williams
The thyroid and the skeleton.
Clinical endocrinology 2004;61(3):285-98.
2004: Sarah Frankton; Clare B Harvey; Lisa M Gleason; Abdessamad Fadel; Graham R Williams
Multiple messenger ribonucleic acid variants regulate cell-specific expression of human thyroid hormone receptor beta1.
Molecular endocrinology (Baltimore, Md.) 2004;18(7):1631-42.
2004: Maha T Barakat; Houman Ashrafian; Jeannie F Todd; Joseph J Boyle; John A Lynn; Graham R Williams
Renal magnesium loss causing hypomagnesaemia and autonomous hyperparathyroidism.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2004;19(4):977-80.
2003: J H Duncan Bassett; Clare B Harvey; Graham R Williams
Mechanisms of thyroid hormone receptor-specific nuclear and extra nuclear actions.
Molecular and cellular endocrinology 2003;213(1):1-11.
2003: J H Duncan Bassett; Graham R Williams
The molecular actions of thyroid hormone in bone.
Trends in endocrinology and metabolism: TEM 2003;14(8):356-64.
2003: David A Stevens; Clare B Harvey; Anthea J Scott; Patrick J O'Shea; Joanna C Barnard; Allan J Williams; Gerard Brady; Jacques Samarut; Olivier Chassande; Graham R Williams
Thyroid hormone activates fibroblast growth factor receptor-1 in bone.
Molecular endocrinology (Baltimore, Md.) 2003;17(9):1751-66.
2003: Patrick J O'Shea; Clare B Harvey; Hideyo Suzuki; Masahiro Kaneshige; Kumiko Kaneshige; Sheue-Yann Cheng; Graham R Williams
A thyrotoxic skeletal phenotype of advanced bone formation in mice with resistance to thyroid hormone.
Molecular endocrinology (Baltimore, Md.) 2003;17(7):1410-24.
2002: Patrick J O'Shea; Graham R Williams
Insight into the physiological actions of thyroid hormone receptors from genetically modified mice.
The Journal of endocrinology 2002;175(3):553-70.
2002: Thomas Siebler; Helen Robson; Stephen M Shalet; Graham R Williams
Dexamethasone inhibits and thyroid hormone promotes differentiation of mouse chondrogenic ATDC5 cells.
Bone 2002;31(4):457-64.
2002: Helen Robson; Thomas Siebler; Stephen M Shalet; Graham R Williams
Interactions between GH, IGF-I, glucocorticoids, and thyroid hormones during skeletal growth.
Pediatric research 2002;52(2):137-47.
2002: Clare B Harvey; Graham R Williams
Mechanism of thyroid hormone action.
Thyroid : official journal of the American Thyroid Association 2002;12(6):441-6.
2002: Clare B Harvey; Patrick J O'Shea; Anthea J Scott; Helen Robson; Thomas Siebler; Stephen M Shalet; Jacques Samarut; Olivier Chassande; Graham R Williams
Molecular mechanisms of thyroid hormone effects on bone growth and function.
Molecular genetics and metabolism 2002;75(1):17-30.
2002: Thomas Siebler; Helen Robson; M Bromley; DA Stevens; Stephen M Shalet; Graham R Williams
Thyroid status affects number and localization of thyroid hormone receptor expressing mast cells in bone marrow.
Bone 2002;30(1):259-66.
2001: Karine Gauthier; Michelina Plateroti; Clare B Harvey; Graham R Williams; Roy E Weiss; Samuel Refetoff; James F Willott; VS Sundin; Jean-Paul Roux; Luc Malaval; M Hara; Jacques Samarut; Olivier Chassande
Genetic analysis reveals different functions for the products of the thyroid hormone receptor alpha locus.
Molecular and cellular biology 2001;21(14):4748-60.
2001: Thomas Siebler; Helen Robson; Stephen M Shalet; Graham R Williams
Glucocorticoids, thyroid hormone and growth hormone interactions: implications for the growth plate.
Hormone research 2001;56 Suppl 1():7-12.
2000: DA Stevens; R P Hasserjian; Helen Robson; Thomas Siebler; Stephen M Shalet; Graham R Williams
Thyroid hormones regulate hypertrophic chondrocyte differentiation and expression of parathyroid hormone-related peptide and its receptor during endochondral bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(12):2431-42.
2000: Helen Robson; Thomas Siebler; DA Stevens; Stephen M Shalet; Graham R Williams
Thyroid hormone acts directly on growth plate chondrocytes to promote hypertrophic differentiation and inhibit clonal expansion and cell proliferation.
Endocrinology 2000;141(10):3887-97.