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Huw Williams

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Russell R A Kitson; William Lewis; Chuan-Hsin Chang; Adrienne L Davis; Donna L Dehn; Chrisostomos Prodromou; S Mark Roe; David Ross; David Siegel; Huw E L Williams; Rui Xiong; Christopher J Moody
Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.
Jörg Linder; Thomas P Garner; Huw E L Williams; Mark S Searle; Christopher J Moody
Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes.
Thomas P Garner; Huw E L Williams; Katarzyna I Gluszyk; Stephen Roe; Neil J Oldham; Malcolm F G Stevens; John E Moses; Mark S Searle
Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures.

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All Publications

2013: Russell R A Kitson; William Lewis; Chuan-Hsin Chang; Adrienne L Davis; Donna L Dehn; Chrisostomos Prodromou; S Mark Roe; David Ross; David Siegel; Huw E L Williams; Rui Xiong; Christopher J Moody
Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.
Nature chemistry 2013;5(4):307-14.
2011: Jörg Linder; Thomas P Garner; Huw E L Williams; Mark S Searle; Christopher J Moody
Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes.
Journal of the American Chemical Society 2011;133(4):1044-51.
2009: Thomas P Garner; Huw E L Williams; Katarzyna I Gluszyk; Stephen Roe; Neil J Oldham; Malcolm F G Stevens; John E Moses; Mark S Searle
Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures.
Organic & biomolecular chemistry 2009;7(20):4194-200.
2009: Andrew P Townsend; Stefanie Roth; Huw E L Williams; Eleni Stylianou; Neil R Thomas
New S-adenosyl-L-methionine analogues: synthesis and reactivity studies.
Organic letters 2009;11(14):2976-9.
2009: Graham D Balkwill; Thomas P Garner; Huw E L Williams; Mark S Searle
Folding topology of a bimolecular DNA quadruplex containing a stable mini-hairpin motif within the diagonal loop.
Journal of molecular biology 2009;385(5):1600-15.
2008: Anita M Rea; Emma R Simpson; Jill K Meldrum; Huw E L Williams; Mark S Searle
Aromatic residues engineered into the beta-turn nucleation site of ubiquitin lead to a complex folding landscape, non-native side-chain interactions, and kinetic traps.
Biochemistry 2008;47(48):12910-22.
2007: Graham D Balkwill; Huw E L Williams; Mark S Searle
Structure and folding dynamics of a DNA hairpin with a stabilising d(GNA) trinucleotide loop: influence of base pair mis-matches and point mutations on conformational equilibria.
Organic & biomolecular chemistry 2007;5(5):832-9.
2004: Mark S Searle; Huw E L Williams; Cathal T Gallagher; Richard J Grant; Malcolm F G Stevens
Structure and K+ ion-dependent stability of a parallel-stranded DNA quadruplex containing a core A-tetrad.
Organic & biomolecular chemistry 2004;2(6):810-2.
2003: Mark S Searle; Allister J Maynard; Huw E L Williams
DNA recognition by the anthracycline antibiotic respinomycin D: NMR structure of the intercalation complex with d(AGACGTCT)2.
Organic & biomolecular chemistry 2003;1(1):60-6.
2002: Michelle Colgrave; Huw E L Williams; Mark S Searle
Structure of a drug-induced DNA T-bulge: implications for DNA frameshift mutations.
Angewandte Chemie (International ed. in English) 2002;41(24):4754-6.
2002: Huw E L Williams; Michelle Colgrave; Mark S Searle
Drug recognition of a DNA single strand break: nogalamycin intercalation between coaxially stacked hairpins.
European journal of biochemistry / FEBS 2002;269(6):1726-33.
1999: Huw E L Williams; Mark S Searle
Structure, dynamics and hydration of the nogalamycin-d(ATGCAT)2Complex determined by NMR and molecular dynamics simulations in solution.
Journal of molecular biology 1999;290(3):699-716.
1998: Gary J Sharman; N Kenward; Huw E L Williams; M Landon; RJ Mayer; Mark S Searle
Prion protein fragments spanning helix 1 and both strands of beta sheet (residues 125-170) show evidence for predominantly helical propensity by CD and NMR.
Folding & design 1998;3(5):313-20.