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Richard Williams

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Saba Alzabin; Richard O Williams
Effector T cells in rheumatoid arthritis: lessons from animal models.
Lukasz R Kolodziej; Ewa M Paleolog; Richard O Williams
Kynurenine metabolism in health and disease.
Kay E McNamee; Richard O Williams; Saba Alzabin; Praveen Anand; Eugene Eyo Akujuru; Jane P Hughes; Julia J Inglis
IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration.

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All Publications

2011: Saba Alzabin; Richard O Williams
Effector T cells in rheumatoid arthritis: lessons from animal models.
FEBS letters 2011;585(23):3649-59.
2011: Lukasz R Kolodziej; Ewa M Paleolog; Richard O Williams
Kynurenine metabolism in health and disease.
Amino acids 2011;41(5):1173-83.
2011: Kay E McNamee; Richard O Williams; Saba Alzabin; Praveen Anand; Eugene Eyo Akujuru; Jane P Hughes; Julia J Inglis
IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration.
Pain 2011;152(8):1838-45.
2010: Stefan K Drexler; Philip Kong; Julia Inglis; Richard O Williams; Cecilia Garlanda; Alberto Mantovani; Amir S Yazdi; Fionula Brennan; Eugene Eyo Akujuru; Brian M J Foxwell
SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis.
Arthritis and rheumatism 2010;62(8):2249-61.
2010: Kay E McNamee; Annika Burleigh; Luke L Gompels; Eugene Eyo Akujuru; Shelley J Allen; Richard O Williams; David Dawbarn; Tonia L Vincent; Julia J Inglis
Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain.
Pain 2010;149(2):386-92.
2010: Fiona E McCann; Andrew C Palfreeman; Melanie Andrews; Dany P Perocheau; Julia J Inglis; Peter Schafer; Eugene Eyo Akujuru; Richard O Williams; Fionula M Brennan
Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.
Arthritis research & therapy 2010;12(3):R107.
2010: Clare A Notley; Fiona E McCann; Julia J Inglis; Richard O Williams
ANTI-CD3 therapy expands the numbers of CD4+ and CD8+ Treg cells and induces sustained amelioration of collagen-induced arthritis.
Arthritis and rheumatism 2010;62(1):171-8.
2009: Gabriel Criado; Egle Simelyte; Julia J Inglis; David Essex; Richard O Williams
Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis.
Arthritis and rheumatism 2009;60(5):1342-51.
2008: Clare A Notley; Julia J Inglis; Saba Alzabin; Fiona E McCann; Kay E McNamee; Richard O Williams
Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells.
The Journal of experimental medicine 2008;205(11):2491-7.
2008: Julia J Inglis; Kay E McNamee; Shi-Lu Chia; David Essex; Eugene Eyo Akujuru; Richard O Williams; Stephen P Hunt; Tonia L Vincent
Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system.
Arthritis and rheumatism 2008;58(10):3110-9.
2008: Felix I L Clanchy; Richard O Williams
Plasmid DNA as a safe gene delivery vehicle for treatment of chronic inflammatory disease.
Expert opinion on biological therapy 2008;8(10):1507-19.
2008: Egle Simelyte; Gabriel Criado; David Essex; Robert A Uger; Eugene Eyo Akujuru; Richard O Williams
CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis.
Arthritis and rheumatism 2008;58(4):1038-43.
2008: Julia J Inglis; Egle Simelyte; Fiona E McCann; Gabriel Criado; Richard O Williams
Protocol for the induction of arthritis in C57BL/6 mice.
Nature protocols 2008;3(4):612-8.
2007: Julia J Inglis; G Criado; M Andrews; Eugene Eyo Akujuru; Richard O Williams; M L Selley
The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis.
Rheumatology (Oxford, England) 2007;46(9):1428-32.
2007: Richard O Williams; Ewa Paleolog; Eugene Eyo Akujuru
Cytokine inhibitors in rheumatoid arthritis and other autoimmune diseases.
Current opinion in pharmacology 2007;7(4):412-7.
2007: Richard O Williams
Collagen-induced arthritis in mice.
Methods in molecular medicine 2007;136():191-9.
2007: Julia J Inglis; Gabriel Criado; Mino Medghalchi; Melanie Andrews; Ann Sandison; Eugene Eyo Akujuru; Richard O Williams
Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen.
Arthritis research & therapy 2007;9(5):R113.
2007: Richard O Williams
Collagen-induced arthritis in mice: a major role for tumor necrosis factor-alpha.
Methods in molecular biology (Clifton, N.J.) 2007;361():265-84.
2006: L Marinova-Mutafchieva; Cem Gabay; K Funa; Richard O Williams
Remission of collagen-induced arthritis is associated with high levels of transforming growth factor-beta expression in the joint.
Clinical and experimental immunology 2006;146(2):287-93.
2005: Richard O Williams; Julia J Inglis; Egle Simelyte; Gabriel Criado; Percy F Sumariwalla
Analysing the effect of novel therapies on cytokine expression in experimental arthritis.
International journal of experimental pathology 2005;86(5):267-78.
2005: Eugene Eyo Akujuru; Fionula M Brennan; Brian M J Foxwell; Peter C Taylor; Richard O Williams; R N Maini
Anti-TNF therapy: where have we got to in 2005?
Journal of autoimmunity 2005;25 Suppl():26-8.
2004: Peter C Taylor; Richard O Williams; Eugene Eyo Akujuru
Tumour necrosis factor alpha as a therapeutic target for immune-mediated inflammatory diseases.
Current opinion in biotechnology 2004;15(6):557-63.
2004: Eugene Eyo Akujuru; Fionula M Brennan; Richard O Williams; Jim Woody; Ravinder N Maini
The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis.
Best practice & research. Clinical rheumatology 2004;18(1):59-80.
2004: Richard O Williams
Collagen-induced arthritis as a model for rheumatoid arthritis.
Methods in molecular medicine 2004;98():207-16.
2004: Patricia Ozegbe; Andrew D Foey; Salman Ahmed; Richard O Williams
Impact of cAMP on the T-cell response to type II collagen.
Immunology 2004;111(1):35-40.
2002: Richard O Williams
Cutting edge: A-kinase anchor proteins are involved in maintaining resting T cells in an inactive state.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(11):5392-6.
2002: L Marinova-Mutafchieva; Richard O Williams; K Funa; Ravinder N Maini; Nathan J Zvaifler
Inflammation is preceded by tumor necrosis factor-dependent infiltration of mesenchymal cells in experimental arthritis.
Arthritis and rheumatism 2002;46(2):507-13.
2002: Richard O Williams
Therapeutic effect of vasoactive intestinal peptide in collagen-induced arthritis.
Arthritis and rheumatism 2002;46(1):271-3.
2001: Anne-Marie Malfait; Richard O Williams; AS Malik; Ravinder N Maini; Eugene Eyo Akujuru
Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies.
Arthritis and rheumatism 2001;44(5):1215-24.
2001: Cem Gabay; L Marinova-Mutafchieva; Richard O Williams; J P Gigley; DM Butler; Eugene Eyo Akujuru; William P Arend
Increased production of intracellular interleukin-1 receptor antagonist type I in the synovium of mice with collagen-induced arthritis: a possible role in the resolution of arthritis.
Arthritis and rheumatism 2001;44(2):451-62.
2000: Richard O Williams; L Marinova-Mutafchieva; Eugene Eyo Akujuru; Ravinder N Maini
Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7240-5.
2000: L Marinova-Mutafchieva; Richard O Williams; C Mauri; LJ Mason; MJ Walmsley; P C Taylor; Eugene Eyo Akujuru; Ravinder N Maini
A comparative study into the mechanisms of action of anti-tumor necrosis factor alpha, anti-CD4, and combined anti-tumor necrosis factor alpha/anti-CD4 treatment in early collagen-induced arthritis.
Arthritis and rheumatism 2000;43(3):638-44.
1999: Richard O Williams; Anne-Marie Malfait; DM Butler; MJ Walmsley; Eugene Eyo Akujuru; Ravinder N Maini
Combination therapy with DMARDs and biological agents in collagen-induced arthritis.
Clinical and experimental rheumatology 1999;17(6 Suppl 18):S115-20.
1999: E Quattrocchi; MJ Walmsley; K Browne; Richard O Williams; L Marinova-Mutafchieva; W Buurman; DM Butler; Eugene Eyo Akujuru
Paradoxical effects of adenovirus-mediated blockade of TNF activity in murine collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(2):1000-9.
1999: Kostas Triantaphyllopoulos; Richard O Williams; H Tailor; Yuti Chernajovsky
Amelioration of collagen-induced arthritis and suppression of interferon-gamma, interleukin-12, and tumor necrosis factor alpha production by interferon-beta gene therapy.
Arthritis and rheumatism 1999;42(1):90-9.
1998: Richard O Williams
Rodent models of arthritis: relevance for human disease.
Clinical and experimental immunology 1998;114(3):330-2.
1998: Richard O Williams; C Mauri; LJ Mason; L Marinova-Mutafchieva; S E Ross; Eugene Eyo Akujuru; Ravinder N Maini
Therapeutic actions of cyclosporine and anti-tumor necrosis factor alpha in collagen-induced arthritis and the effect of combination therapy.
Arthritis and rheumatism 1998;41(10):1806-12.
1998: Richard O Williams
Combination therapy in mice: what can we learn that may be useful for understanding rheumatoid arthritis?
Springer seminars in immunopathology 1998;20(1-2):165-80.
1997: S E Ross; Richard O Williams; LJ Mason; C Mauri; L Marinova-Mutafchieva; Anne-Marie Malfait; Ravinder N Maini; Eugene Eyo Akujuru
Suppression of TNF-alpha expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipram.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):6253-9.
1997: A C Horsfall; DM Butler; L Marinova; P J Warden; Richard O Williams; Ravinder N Maini; Eugene Eyo Akujuru
Suppression of collagen-induced arthritis by continuous administration of IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(11):5687-96.
1997: Ravinder N Maini; M Elliott; Fionula M Brennan; Richard O Williams; Eugene Eyo Akujuru
TNF blockade in rheumatoid arthritis: implications for therapy and pathogenesis.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1997;105(4):257-63.
1997: L Marinova-Mutafchieva; Richard O Williams; LJ Mason; C Mauri; Eugene Eyo Akujuru; Ravinder N Maini
Dynamics of proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis (CIA).
Clinical and experimental immunology 1997;107(3):507-12.
1996: C Mauri; Richard O Williams; MJ Walmsley; Eugene Eyo Akujuru
Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen-induced arthritis.
European journal of immunology 1996;26(7):1511-8.
1996: MJ Walmsley; P D Katsikis; E Abney; S Parry; Richard O Williams; Ravinder N Maini; Eugene Eyo Akujuru
Interleukin-10 inhibition of the progression of established collagen-induced arthritis.
Arthritis and rheumatism 1996;39(3):495-503.
1995: Richard O Williams; J Ghrayeb; Eugene Eyo Akujuru; Ravinder N Maini
Successful therapy of collagen-induced arthritis with TNF receptor-IgG fusion protein and combination with anti-CD4.
Immunology 1995;84(3):433-9.
1992: Richard O Williams; C Plater-Zyberk; david williams; Ravinder N Maini
Successful transfer of collagen-induced arthritis to severe combined immunodeficient (SCID) mice.
Clinical and experimental immunology 1992;88(3):455-60.
1992: Eugene Eyo Akujuru; Fionula M Brennan; Richard O Williams; A P Cope; D L Gibbons; P D Katsikis; Ravinder N Maini
Evaluation of the role of cytokines in autoimmune disease: the importance of TNF alpha in rheumatoid arthritis.
Progress in growth factor research 1992;4(3):247-55.