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Todd Williams

Research Profile

Procedures

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

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Oxidation-Reduction

Chemicals & Drugs

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Sarcoplasmic Reticulum

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Publications

TOP 3
Lei Jiang; Elias K Michaelis; Misty D Bechtel; Nadezhda A Galeva; Todd D Williams; Mary L Michaelis
Decreases in plasma membrane Ca²⁺-ATPase in brain synaptic membrane rafts from aged rats.
Olivier Mozziconacci; Todd D Williams; Christian Schöneich
Intramolecular hydrogen transfer reactions of thiyl radicals from glutathione: formation of carbon-centered radical at Glu, Cys, and Gly.
Diganta Sarma; Jeff L Staudinger; Todd D Williams; Nadezhda A Galeva; Heather Hajovsky; Yakov M Koen; Robert P Hanzlik
Covalent modification of lipids and proteins in rat hepatocytes and in vitro by thioacetamide metabolites.

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All Publications

2012: Lei Jiang; Elias K Michaelis; Misty D Bechtel; Nadezhda A Galeva; Todd D Williams; Mary L Michaelis
Decreases in plasma membrane Ca²⁺-ATPase in brain synaptic membrane rafts from aged rats.
Journal of neurochemistry 2012;123(5):689-99.
2012: Olivier Mozziconacci; Todd D Williams; Christian Schöneich
Intramolecular hydrogen transfer reactions of thiyl radicals from glutathione: formation of carbon-centered radical at Glu, Cys, and Gly.
Chemical research in toxicology 2012;25(9):1842-61.
2012: Diganta Sarma; Jeff L Staudinger; Todd D Williams; Nadezhda A Galeva; Heather Hajovsky; Yakov M Koen; Robert P Hanzlik
Covalent modification of lipids and proteins in rat hepatocytes and in vitro by thioacetamide metabolites.
Chemical research in toxicology 2012;25(9):1868-77.
2012: Yakov M Koen; Ke Liu; Jeffrey L Staudinger; Todd D Williams; Nadezhda A Galeva; Heather Hajovsky; Robert P Hanzlik
Liver protein targets of hepatotoxic 4-bromophenol metabolites.
Chemical research in toxicology 2012;25(8):1777-86.
2012: Maulik Trivedi; Todd D Williams; Jennifer S Laurence; C Russell Middaugh; Teruna J Siahaan
Improving the stability of the EC1 domain of E-cadherin by thiol alkylation of the cysteine residue.
International journal of pharmaceutics 2012;431(1-2):16-25.
2012: Yakov M Koen; R Scott Obach; Diganta Sarma; Todd D Williams; Nadezhda A Galeva; Robert P Hanzlik
Identification of protein targets of reactive metabolites of tienilic acid in human hepatocytes.
Chemical research in toxicology 2012;25(5):1145-54.
2012: Prakash Manikwar; Todd D Williams; Ahmed H Badawi; Barlas Büyüktimkin; Nadezhda A Galeva; Paul Kiptoo; Teruna J Siahaan
I-domain-antigen conjugate (IDAC) for delivering antigenic peptides to APC: synthesis, characterization, and in vivo EAE suppression.
Bioconjugate chemistry 2012;23(3):509-17.
2012: Sara Maatta; Mary R Roth; Brad Scheu; Pamela Tamura; Xuemin Wang; Maoyin Li; Todd D Williams; Ruth Welti
Levels of Arabidopsis thaliana Leaf Phosphatidic Acids, Phosphatidylserines, and Most Trienoate-Containing Polar Lipid Molecular Species Increase during the Dark Period of the Diurnal Cycle.
Frontiers in plant science 2012;3():49.
2011: Prakash Manikwar; Todd D Williams; Tahl Zimmerman; Francisco Jose Blanco; Teruna J Siahaan
Rapid identification of fluorochrome modification sites in proteins by LC ESI-Q-TOF mass spectrometry.
Bioconjugate chemistry 2011;22(7):1330-6.
2011: Anthonius A M Heemskerk; Leon van Haandel; Joshua M Woods; Elinore F McCance-Katz; Todd D Williams; John F Stobaugh; MD Faiman
LC-MS/MS method for the determination of carbamathione in human plasma.
Journal of pharmaceutical and biomedical analysis 2011;54(4):799-806.
2010: Hong Zhao; Paul Kiptoo; Todd D Williams; Teruna J Siahaan; Elizabeth M Topp
Immune response to controlled release of immunomodulating peptides in a murine experimental autoimmune encephalomyelitis (EAE) model.
Journal of controlled release : official journal of the Controlled Release Society 2010;141(2):145-52.
2010: Swetha Kaul; Todd D Williams; Craig E Lunte; MD Faiman
LC-MS/MS determination of carbamathione in microdialysis samples from rat brain and plasma.
Journal of pharmaceutical and biomedical analysis 2010;51(1):186-91.
2009: Robert D Winefield; Todd D Williams; Richard H Himes
A label-free mass spectrometry method for the quantification of protein isotypes.
Analytical biochemistry 2009;395(2):217-23.
2009: Leon van Haandel; Mara L Becker; J Steven Leeder; Todd D Williams; John F Stobaugh
A novel high-performance liquid chromatography/mass spectrometry method for improved selective and sensitive measurement of methotrexate polyglutamation status in human red blood cells.
Rapid communications in mass spectrometry : RCM 2009;23(23):3693-702.
2009: Lei Zhang; Todd D Williams; Elizabeth M Topp
Reversibility and regioselectivity in thiol/disulfide interchange of tocinoic acid with glutathione in lyophilized solids.
Journal of pharmaceutical sciences 2009;98(9):3312-8.
2009: Sandipan Sinha; Lei Zhang; Shaofeng Duan; Todd D Williams; Josef Vlasak; Roxana Ionescu; Elizabeth M Topp
Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody.
Protein science : a publication of the Protein Society 2009;18(8):1573-84.
2009: Andria L Skinner; Anthony A Vartia; Todd D Williams; Jennifer S Laurence
Enzyme activity of phosphatase of regenerating liver is controlled by the redox environment and its C-terminal residues.
Biochemistry 2009;48(20):4262-72.
2009: Victor S Sharov; Nadezhda A Galeva; Elena S Dremina; Todd D Williams; Christian Schöneich
Inactivation of rabbit muscle glycogen phosphorylase b by peroxynitrite revisited: does the nitration of Tyr613 in the allosteric inhibition site control enzymatic function?
Archives of biochemistry and biophysics 2009;484(2):155-66.
2008: Olivier Mozziconacci; Todd D Williams; Bruce A Kerwin; Christian Schöneich
Reversible intramolecular hydrogen transfer between protein cysteine thiyl radicals and alpha C-H bonds in insulin: control of selectivity by secondary structure.
The journal of physical chemistry. B 2008;112(49):15921-32.
2008: Patrick R Porubsky; Emily E Scott; Todd D Williams
p-dimethylaminocinnamaldehyde derivatization for colorimetric detection and HPLC-UV/vis-MS/MS identification of indoles.
Archives of biochemistry and biophysics 2008;475(1):14-7.
2008: Jianwen Fang; Yinghua Dong; Todd D Williams; Gerald H Lushington
Feature selection in validating mass spectrometry database search results.
Journal of bioinformatics and computational biology 2008;6(1):223-40.
2008: Yunsong Li; Todd D Williams; Elizabeth M Topp
Effects of excipients on protein conformation in lyophilized solids by hydrogen/deuterium exchange mass spectrometry.
Pharmaceutical research 2008;25(2):259-67.
2007: Yunsong Li; Todd D Williams; Richard L Schowen; Elizabeth M Topp
Trehalose and calcium exert site-specific effects on calmodulin conformation in amorphous solids.
Biotechnology and bioengineering 2007;97(6):1650-3.
2007: Yunsong Li; Todd D Williams; Richard L Schowen; Elizabeth M Topp
Characterizing protein structure in amorphous solids using hydrogen/deuterium exchange with mass spectrometry.
Analytical biochemistry 2007;366(1):18-28.
2007: Tao Ji; Keisuke Ikehata; Yakov M Koen; Steven W Esch; Todd D Williams; Robert P Hanzlik
Covalent modification of microsomal lipids by thiobenzamide metabolites in vivo.
Chemical research in toxicology 2007;20(4):701-8.
2007: Yongming Sang; M Teresa Ortega; Kristina Rune; Wang Xiau; Guolong Zhang; Jose L Soulages; Gerald H Lushington; Jianwen Fang; Todd D Williams; Frank Blecha; Tonatiuh Melgarejo
Canine cathelicidin (K9CATH): gene cloning, expression, and biochemical activity of a novel pro-myeloid antimicrobial peptide.
Developmental and comparative immunology 2007;31(12):1278-96.
2007: Steven Wynn Esch; Pamela Tamura; Alexis A Sparks; Mary R Roth; Shivakumar Devaiah; Ernst Heinz; Xuemin Wang; Todd D Williams; Ruth Welti
Rapid characterization of the fatty acyl composition of complex lipids by collision-induced dissociation time-of-flight mass spectrometry.
Journal of lipid research 2007;48(1):235-41.
2006: Yijia Xiong; Baowei Chen; Heather S Smallwood; Ramona J Bieber Urbauer; Lye Meng Markille; Nadezhda A Galeva; Todd D Williams; Thomas C Squier
High-affinity and cooperative binding of oxidized calmodulin by methionine sulfoxide reductase.
Biochemistry 2006;45(49):14642-54.
2006: Yakov M Koen; Weimin Yue; Nadezhda A Galeva; Todd D Williams; Robert P Hanzlik
Site-specific arylation of rat glutathione s-transferase A1 and A2 by bromobenzene metabolites in vivo.
Chemical research in toxicology 2006;19(11):1426-34.
2006: Christen M Buseman; Pamela Tamura; Alexis A Sparks; Ethan J Baughman; Sara Maatta; Jian Zhao; Mary R Roth; Steven Wynn Esch; Jyoti Shah; Todd D Williams; Ruth Welti
Wounding stimulates the accumulation of glycerolipids containing oxophytodienoic acid and dinor-oxophytodienoic acid in Arabidopsis leaves.
Plant physiology 2006;142(1):28-39.
2006: Colette A Sacksteder; Jennifer E Whittier; Yijia Xiong; Jinhui Li; Nadezhda A Galeva; Michael E Jacoby; Samuel O Purvine; Todd D Williams; Martin Rechsteiner; Diana J Bigelow; Thomas C Squier
Tertiary structural rearrangements upon oxidation of Methionine145 in calmodulin promotes targeted proteasomal degradation.
Biophysical journal 2006;91(4):1480-93.
2006: Victor S Sharov; Nadezhda A Galeva; Jaroslaw Kanski; Todd D Williams; Christian Schöneich
Age-associated tyrosine nitration of rat skeletal muscle glycogen phosphorylase b: characterization by HPLC-nanoelectrospray-tandem mass spectrometry.
Experimental gerontology 2006;41(4):407-16.
2006: Erik Floor; Anne M Maples; Carolyn A Rankin; Vamsee M Yaganti; Sylvan S Shank; Grant S Nichols; Michael O'Laughlin; Nadezhda A Galeva; Todd D Williams
A one-carbon modification of protein lysine associated with elevated oxidative stress in human substantia nigra.
Journal of neurochemistry 2006;97(2):504-14.
2006: Victor S Sharov; Elena S Dremina; Nadezhda A Galeva; Todd D Williams; Christian Schöneich
Quantitative mapping of oxidation-sensitive cysteine residues in SERCA in vivo and in vitro by HPLC-electrospray-tandem MS: selective protein oxidation during biological aging.
The Biochemical journal 2006;394(Pt 3):605-15.
2005: Weimin Yue; Yakov M Koen; Todd D Williams; Robert P Hanzlik
Use of isotopic signatures for mass spectral detection of protein adduction by chemically reactive metabolites of bromobenzene: studies with model proteins.
Chemical research in toxicology 2005;18(11):1748-54.
2005: Tatyana V Knyushko; Victor S Sharov; Todd D Williams; Christian Schöneich; Diana J Bigelow
3-Nitrotyrosine modification of SERCA2a in the aging heart: a distinct signature of the cellular redox environment.
Biochemistry 2005;44(39):13071-81.
2005: Nadezhda A Galeva; S Wynn Esch; Todd D Williams; Lye Meng Markille; Thomas C Squier
Rapid method for quantifying the extent of methionine oxidation in intact calmodulin.
Journal of the American Society for Mass Spectrometry 2005;16(9):1470-80.
2004: Kenneth D Osborn; Ryan K Bartlett; Abhijit Mandal; Asma Zaidi; Ramona J Bieber Urbauer; Jeffrey L Urbauer; Nadezhda A Galeva; Todd D Williams; Carey K Johnson
Single-molecule dynamics reveal an altered conformation for the autoinhibitory domain of plasma membrane Ca(2+)-ATPase bound to oxidatively modified calmodulin.
Biochemistry 2004;43(40):12937-44.
2004: Michael William Allen; Ramona J Bieber Urbauer; Asma Zaidi; Todd D Williams; Jeffrey L Urbauer; Carey K Johnson
Fluorescence labeling, purification, and immobilization of a double cysteine mutant calmodulin fusion protein for single-molecule experiments.
Analytical biochemistry 2004;325(2):273-84.
2003: Sangita Biswas; Homigol Biesiada; Todd D Williams; Steven M LeVine
Substrate reduction intervention by L-cycloserine in twitcher mice (globoid cell leukodystrophy) on a B6;CAST/Ei background.
Neuroscience letters 2003;347(1):33-6.
2003: Stephen W Esch; Todd D Williams; S Biswas; Anuradha Chakrabarty; Steven M LeVine
Sphingolipid profile in the CNS of the twitcher (globoid cell leukodystrophy) mouse: a lipidomics approach.
Cellular and molecular biology (Noisy-le-Grand, France) 2003;49(5):779-87.
2003: Christian Schöneich; Todd D Williams
CU(II)-catalyzed oxidation of Alzheimer's disease beta-amyloid peptide and related sequences: remarkably different selectivities of neurotoxic betaAP1-40 and non-toxic betaAP40-1.
Cellular and molecular biology (Noisy-le-Grand, France) 2003;49(5):753-61.
2003: Ryan M Krisko; Mark A Schieferecke; Todd D Williams; Craig E Lunte
Determination of bupivacaine and metabolites in rat urine using capillary electrophoresis with mass spectrometric detection.
Electrophoresis 2003;24(14):2340-7.
2003: Ruth Welti; Xuemin Wang; Todd D Williams
Electrospray ionization tandem mass spectrometry scan modes for plant chloroplast lipids.
Analytical biochemistry 2003;314(1):149-52.
2003: Heather S Smallwood; Nadezhda A Galeva; Ryan K Bartlett; Ramona J Bieber Urbauer; Todd D Williams; Jeffrey L Urbauer; Thomas C Squier
Selective nitration of Tyr99 in calmodulin as a marker of cellular conditions of oxidative stress.
Chemical research in toxicology 2003;16(1):95-102.
2002: Victor S Sharov; Nadezhda A Galeva; Tatyana V Knyushko; Diana J Bigelow; Todd D Williams; Christian Schöneich
Two-dimensional separation of the membrane protein sarcoplasmic reticulum Ca-ATPase for high-performance liquid chromatography-tandem mass spectrometry analysis of posttranslational protein modifications.
Analytical biochemistry 2002;308(2):328-35.
2002: Ruth Welti; Weiqi Li; Maoyin Li; Yongming Sang; Homigol Biesiada; Han-E Zhou; C B Rajashekar; Todd D Williams; Xuemin Wang
Profiling membrane lipids in plant stress responses. Role of phospholipase D alpha in freezing-induced lipid changes in Arabidopsis.
The Journal of biological chemistry 2002;277(35):31994-2002.
2002: Sangita Biswas; Homigol Biesiada; Todd D Williams; Steven M LeVine
Delayed clinical and pathological signs in twitcher (globoid cell leukodystrophy) mice on a C57BL/6 x CAST/Ei background.
Neurobiology of disease 2002;10(3):344-57.
2002: Christian Schöneich; Todd D Williams
Cu(II)-catalyzed oxidation of beta-amyloid peptide targets His13 and His14 over His6: Detection of 2-Oxo-histidine by HPLC-MS/MS.
Chemical research in toxicology 2002;15(5):717-22.
2002: Susan W Hovorka; Homigol Biesiada; Todd D Williams; Andreas Hühmer; Christian Schöneich
High sensitivity of Zn2+ insulin to metal-catalyzed oxidation: detection of 2-oxo-histidine by tandem mass spectrometry.
Pharmaceutical research 2002;19(4):530-7.
2002: Susan W Hovorka; Todd D Williams; Christian Schöneich
Characterization of the metal-binding site of bovine growth hormone through site-specific metal-catalyzed oxidation and high-performance liquid chromatography-tandem mass spectrometry.
Analytical biochemistry 2002;300(2):206-11.
2000: Yakov M Koen; Todd D Williams; Robert P Hanzlik
Identification of three protein targets for reactive metabolites of bromobenzene in rat liver cytosol.
Chemical research in toxicology 2000;13(12):1326-35.
2000: RI Viner; Todd D Williams; Christian Schöneich
Nitric oxide-dependent modification of the sarcoplasmic reticulum Ca-ATPase: localization of cysteine target sites.
Free radical biology & medicine 2000;29(6):489-96.
1999: RI Viner; Todd D Williams; Christian Schöneich
Peroxynitrite modification of protein thiols: oxidation, nitrosylation, and S-glutathiolation of functionally important cysteine residue(s) in the sarcoplasmic reticulum Ca-ATPase.
Biochemistry 1999;38(38):12408-15.
1999: Stephen W Esch; MD Morton; Todd D Williams; Clarence S Buller
A novel trisaccharide glycolipid biosurfactant containing trehalose bears ester-linked hexanoate, succinate, and acyloxyacyl moieties: NMR and MS characterization of the underivatized structure.
Carbohydrate research 1999;319(1-4):112-23.
1999: RI Viner; Deborah A Ferrington; Todd D Williams; Diana J Bigelow; Christian Schöneich
Protein modification during biological aging: selective tyrosine nitration of the SERCA2a isoform of the sarcoplasmic reticulum Ca2+-ATPase in skeletal muscle.
The Biochemical journal 1999;340 ( Pt 3)():657-69.
1999: H Sun; J Gao; Deborah A Ferrington; Homigol Biesiada; Todd D Williams; Thomas C Squier
Repair of oxidized calmodulin by methionine sulfoxide reductase restores ability to activate the plasma membrane Ca-ATPase.
Biochemistry 1999;38(1):105-12.
1998: J Gao; Dan Yin; Yihong Yao; Todd D Williams; Thomas C Squier
Progressive decline in the ability of calmodulin isolated from aged brain to activate the plasma membrane Ca-ATPase.
Biochemistry 1998;37(26):9536-48.
1998: AG Krainev; Todd D Williams; Diana J Bigelow
Enzymatic reduction of 3-nitrotyrosine generates superoxide.
Chemical research in toxicology 1998;11(5):495-502.
1998: J Gao; Daniel H Yin; Yihong Yao; H Sun; Z Qin; C Schöneich; Todd D Williams; Thomas C Squier
Loss of conformational stability in calmodulin upon methionine oxidation.
Biophysical journal 1998;74(3):1115-34.
1997: RI Viner; AG Krainev; Todd D Williams; Christian Schöneich; Diana J Bigelow
Identification of oxidation-sensitive peptides within the cytoplasmic domain of the sarcoplasmic reticulum Ca2+-ATPase.
Biochemistry 1997;36(25):7706-16.
1996: AG Krainev; Todd D Williams; Diana J Bigelow
Oxygen-centered spin adducts of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) and 2H-imidazole 1-oxides.
Journal of magnetic resonance. Series B 1996;111(3):272-80.
1996: Yihong Yao; Dan Yin; G S Jas; K Kuczer; Todd D Williams; Christian Schöneich; Thomas C Squier
Oxidative modification of a carboxyl-terminal vicinal methionine in calmodulin by hydrogen peroxide inhibits calmodulin-dependent activation of the plasma membrane Ca-ATPase.
Biochemistry 1996;35(8):2767-87.
1996: M L Michaelis; Diana J Bigelow; Christian Schöneich; Todd D Williams; L Ramonda; Dan Yin; Andreas Hühmer; Yihong Yao; J Gao; Thomas C Squier
Decreased plasma membrane calcium transport activity in aging brain.
Life sciences 1996;59(5-6):405-12.
1995: AG Krainev; Deborah A Ferrington; Todd D Williams; Thomas C Squier; Diana J Bigelow
Adaptive changes in lipid composition of skeletal sarcoplasmic reticulum membranes associated with aging.
Biochimica et biophysica acta 1995;1235(2):406-18.
1993: B D Shivanna; M R Mejillano; Todd D Williams; Richard H Himes
Exchangeable GTP binding site of beta-tubulin. Identification of cysteine 12 as the major site of cross-linking by direct photoaffinity labeling.
The Journal of biological chemistry 1993;268(1):127-32.
1992: C L Stevenson; Todd D Williams; R J Anderegg; R T Borchardt
Identification and quantitation of tetrapeptide deamidation products by mass spectrometry.
Journal of pharmaceutical and biomedical analysis 1992;10(8):567-75.