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Timothy Williams

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Emma L Wise; Kandace T Bonner; Timothy J Williams; James E Pease
A single nucleotide polymorphism in the CCR3 gene ablates receptor export to the plasma membrane.
Sarah J Collington; Jenny Hallgren; James E Pease; Tatiana G Jones; Barrett J Rollins; John Westwick; K Frank Austen; Timothy J Williams; Tatiana G Jones; Charlotte L Weller
The role of the CCL2/CCR2 axis in mouse mast cell migration in vitro and in vivo.
Andrea Meiser; Anja Mueller; Emma L Wise; Ellen M McDonagh; Sarah J Petit; Namita Saran; Peter C Clark; Timothy J Williams; James E Pease
The chemokine receptor CXCR3 is degraded following internalization and is replenished at the cell surface by de novo synthesis of receptor.

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2010: Emma L Wise; Kandace T Bonner; Timothy J Williams; James E Pease
A single nucleotide polymorphism in the CCR3 gene ablates receptor export to the plasma membrane.
The Journal of allergy and clinical immunology 2010;126(1):150-7.e2.
2010: Sarah J Collington; Jenny Hallgren; James E Pease; Tatiana G Jones; Barrett J Rollins; John Westwick; K Frank Austen; Timothy J Williams; Tatiana G Jones; Charlotte L Weller
The role of the CCL2/CCR2 axis in mouse mast cell migration in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):6114-23.
2008: Andrea Meiser; Anja Mueller; Emma L Wise; Ellen M McDonagh; Sarah J Petit; Namita Saran; Peter C Clark; Timothy J Williams; James E Pease
The chemokine receptor CXCR3 is degraded following internalization and is replenished at the cell surface by de novo synthesis of receptor.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6713-24.
2008: Anja Mueller; Andrea Meiser; Ellen M McDonagh; James M Fox; Sarah J Petit; Georgina Xanthou; Timothy J Williams; James E Pease
CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3.
Journal of leukocyte biology 2008;83(4):875-82.
2007: Emma L Wise; Cécile Emmanuelle Duchesnes; Paula C A da Fonseca; Rodger A Allen; Timothy J Williams; James E Pease
Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation.
The Journal of biological chemistry 2007;282(38):27935-43.
2007: Charlotte L Weller; Sarah J Collington; Adele Hartnell; Dolores M Conroy; Toshihiko Kaise; Jane E Barker; Mark S Wilson; Graham W Taylor; Peter J Jose; Timothy J Williams
Chemotactic action of prostaglandin E2 on mouse mast cells acting via the PGE2 receptor 3.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(28):11712-7.
2006: James E Pease; Timothy J Williams
Chemokines and their receptors in allergic disease.
The Journal of allergy and clinical immunology 2006;118(2):305-18; quiz 319-20.
2006: Cécile Emmanuelle Duchesnes; Philip M Murphy; Timothy J Williams; James E Pease
Alanine scanning mutagenesis of the chemokine receptor CCR3 reveals distinct extracellular residues involved in recognition of the eotaxin family of chemokines.
Molecular immunology 2006;43(8):1221-31.
2006: Timothy J Williams; Charlotte L Weller
Population of lungs by mast cells.
Novartis Foundation symposium 2006;279():142-50; discussion 151-4, 216-9.
2006: James E Pease; Timothy J Williams
The attraction of chemokines as a target for specific anti-inflammatory therapy.
British journal of pharmacology 2006;147 Suppl 1():S212-21.
2005: Edward M Erin; Angela Zacharasiewicz; Grant C Nicholson; Andrew J Tan; Lorna A Higgins; Timothy J Williams; R D Murdoch; Stephen R Durham; Peter J Barnes; Trevor T Hansel
Topical corticosteroid inhibits interleukin-4, -5 and -13 in nasal secretions following allergen challenge.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2005;35(12):1608-14.
2005: Edward M Erin; Brian R Leaker; Angela Zacharasiewicz; Lorna A Higgins; Timothy J Williams; M J Boyce; P de Boer; Stephen R Durham; Peter J Barnes; Trevor T Hansel
Single dose topical corticosteroid inhibits IL-5 and IL-13 in nasal lavage following grass pollen challenge.
Allergy 2005;60(12):1524-9.
2005: Charlotte L Weller; Sarah J Collington; Jeremy K Brown; Hugh Miller; Adam Al-Kashi; Peter Clark; Peter J Jose; Adele Hartnell; Timothy J Williams
Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors.
The Journal of experimental medicine 2005;201(12):1961-71.
2005: Ian Sabroe; Annelies Jorritsma; Victoria E L Stubbs; Georgina Xanthou; Louise A Jopling; Paul D Ponath; Timothy J Williams; Philip M Murphy; James E Pease
The carboxyl terminus of the chemokine receptor CCR3 contains distinct domains which regulate chemotactic signaling and receptor down-regulation in a ligand-dependent manner.
European journal of immunology 2005;35(4):1301-10.
2005: Charlotte L Weller; Peter J Jose; Timothy J Williams
Selective suppression of leukocyte recruitment in allergic inflammation.
Memórias do Instituto Oswaldo Cruz 2005;100 Suppl 1():153-60.
2005: Filipa Lopes de Mendonça; Paula C A da Fonseca; Rhian M Phillips; José W Saldanha; Timothy J Williams; James E Pease
Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist.
The Journal of biological chemistry 2005;280(6):4808-16.
2004: Adele Hartnell; Akos Heinemann; Dolores M Conroy; Robin Wait; Gunter J Sturm; Marco Caversaccio; Peter J Jose; Timothy J Williams
Identification of selective basophil chemoattractants in human nasal polyps as insulin-like growth factor-1 and insulin-like growth factor-2.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6448-57.
2004: Alexandra I Medeiros; Adriana Malheiro; Peter J Jose; Dolores M Conroy; Timothy J Williams; Lúcia H Faccioli
Differential release of MIP-1alpha and eotaxin during infection of mice by Histoplasma capsulatum or inoculation of beta-glucan.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2004;53(8):351-4.
2004: Timothy J Williams
The eosinophil enigma.
The Journal of clinical investigation 2004;113(4):507-9.
2004: James E Pease; Charlotte L Weller; Timothy J Williams
Regulation of eosinophil trafficking in asthma and allergy.
Ernst Schering Research Foundation workshop 2004;(45):85-100.
2003: Coralie Martin; Peter C E Burdon; Gary Bridger; Jose-Carlos Gutierrez-Ramos; Timothy J Williams; Sara M Rankin
Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence.
Immunity 2003;19(4):583-93.
2003: Georgina Xanthou; Timothy J Williams; James E Pease
Molecular characterization of the chemokine receptor CXCR3: evidence for the involvement of distinct extracellular domains in a multi-step model of ligand binding and receptor activation.
European journal of immunology 2003;33(10):2927-36.
2003: Dolores M Conroy; Louise A Jopling; Clare M Lloyd; Martin R Hodge; David Andrew; Timothy J Williams; James E Pease; Ian Sabroe
CCR4 blockade does not inhibit allergic airways inflammation.
Journal of leukocyte biology 2003;74(4):558-63.
2003: Georgina Xanthou; Cécile Emmanuelle Duchesnes; Timothy J Williams; James E Pease
CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11.
European journal of immunology 2003;33(8):2241-50.
2003: Rhian M Phillips; Victoria E L Stubbs; Mandy R Henson; Timothy J Williams; James E Pease; Ian Sabroe
Variations in eosinophil chemokine responses: an investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(12):6190-201.
2003: Fiona J Culley; Emma J Fadlon; Antje Kirchem; Timothy J Williams; Peter J Jose; James E Pease
Proteoglycans are potent modulators of the biological responses of eosinophils to chemokines.
European journal of immunology 2003;33(5):1302-10.
2003: Karen Y Larbi; John P Dangerfield; Fiona J Culley; Diane Marshall; Dorian O Haskard; Peter J Jose; Timothy J Williams; Sussan Nourshargh
P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses.
Journal of leukocyte biology 2003;73(1):65-73.
2002: Andrew Menzies-Gow; Sun Ying; Ian Sabroe; Victoria L Stubbs; Dulce Soler; Timothy J Williams; A Barry Kay
Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(5):2712-8.
2002: Victoria E L Stubbs; Petra Schratl; Adele Hartnell; Timothy J Williams; Bernhard A Peskar; Akos Heinemann; Ian Sabroe
Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils.
The Journal of biological chemistry 2002;277(29):26012-20.
2002: Kayhan T Nouri-Aria; Duncan Wilson; James Francis; Louise A Jopling; Mikila R Jacobson; Martin R Hodge; David Andrew; Stephen Till; Eva-Maria Varga; Timothy J Williams; James E Pease; Clare M Lloyd; Ian Sabroe; Stephen R Durham
CCR4 in human allergen-induced late responses in the skin and lung.
European journal of immunology 2002;32(7):1933-8.
2002: Shannon A Bryan; Peter J Jose; Joanna R Topping; Robert Wilhelm; Carol Soderberg; Denis Kertesz; Peter J Barnes; Timothy J Williams; Trevor T Hansel; Ian Sabroe
Responses of leukocytes to chemokines in whole blood and their antagonism by novel CC-chemokine receptor 3 antagonists.
American journal of respiratory and critical care medicine 2002;165(12):1602-9.
2002: Edward M Erin; Timothy J Williams; Peter J Barnes; Trevor T Hansel
Eotaxin receptor (CCR3) antagonism in asthma and allergic disease.
Current drug targets. Inflammation and allergy 2002;1(2):201-14.
2002: Fiona J Culley; Alan Brown; Nadine Girod; David I Pritchard; Timothy J Williams
Innate and cognate mechanisms of pulmonary eosinophilia in helminth infection.
European journal of immunology 2002;32(5):1376-85.
2002: Miles Edwin Banwell; Neil Samuel Tolley; Timothy J Williams; Tracey Jane Mitchell
Regulation of human eotaxin-3/CCL26 expression: modulation by cytokines and glucocorticoids.
Cytokine 2002;17(6):317-23.
2002: Louise A Jopling; Ian Sabroe; David Andrew; Tracey J Mitchell; You Li; Martin R Hodge; Timothy J Williams; James E Pease
The identification, characterization, and distribution of guinea pig CCR4 and epitope mapping of a blocking antibody.
The Journal of biological chemistry 2002;277(9):6864-73.
2001: R Martinelli; Ian Sabroe; Greg La Rosa; Timothy J Williams; James E Pease
The CC chemokine eotaxin (CCL11) is a partial agonist of CC chemokine receptor 2b.
The Journal of biological chemistry 2001;276(46):42957-64.
2001: BT Au; Mauro Teixeira; PD Collins; Timothy J Williams
Blockade of PAF receptors controls interleukin-8 production by regulating the activation of neutrophil CD11/CD18.
European journal of pharmacology 2001;425(1):65-71.
2001: James E Pease; Timothy J Williams
Eotaxin and asthma.
Current opinion in pharmacology 2001;1(3):248-53.
2001: Shannon A Bryan; MJ Leckie; G Jenkins; Peter J Barnes; Timothy J Williams; Ian Sabroe; Trevor T Hansel
Measurement of granulocyte pharmacodynamics in whole blood by flow cytometry.
Methods in molecular medicine 2001;56():345-55.
2001: Dolores M Conroy; Timothy J Williams
Eotaxin and the attraction of eosinophils to the asthmatic lung.
Respiratory research 2001;2(3):150-6.
2001: Timothy J Williams; Peter J Jose
Neutrophils in chronic obstructive pulmonary disease.
Novartis Foundation symposium 2001;234():136-41; discussion 141-8.
2000: Akos Heinemann; Adele Hartnell; Victoria E L Stubbs; K Murakami; D Soler; Greg La Rosa; Philip W Askenase; Timothy J Williams; Ian Sabroe
Basophil responses to chemokines are regulated by both sequential and cooperative receptor signaling.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7224-33.
2000: Fiona J Culley; Alan Brown; Dolores M Conroy; Ian Sabroe; David I Pritchard; Timothy J Williams
Eotaxin is specifically cleaved by hookworm metalloproteases preventing its action in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6447-53.
2000: Ian Sabroe; Michael Peck; B J Van Keulen; A Jorritsma; G Simmons; P R Clapham; Timothy J Williams; James E Pease
A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.
The Journal of biological chemistry 2000;275(34):25985-92.
2000: Timothy J Williams; Peter J Jose
Role of eotaxin and related CC chemokines in allergy and asthma.
Chemical immunology 2000;78():166-77.
2000: Marco Caversaccio; Adele Hartnell; D Calnan; P Jose; I S Mackay; Mariagrazia Uguccioni; M Baggiolini; Timothy J Williams; Dolores M Conroy
[The role of chemokines in nasal polyps].
Schweizerische medizinische Wochenschrift 2000;Suppl 125():92S-95S.
2000: Sara M Rankin; Dolores M Conroy; Timothy J Williams
Eotaxin and eosinophil recruitment: implications for human disease.
Molecular medicine today 2000;6(1):20-7.
1999: Ian Sabroe; Adele Hartnell; Louise A Jopling; S Bel; Paul D Ponath; James E Pease; PD Collins; Timothy J Williams
Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2946-55.
1999: K Nagai; Simon Larkin; Adele Hartnell; Karen Y Larbi; M Razi Aghakhani; C Windley; D Davies; Roy R Lobb; Timothy J Williams; Sussan Nourshargh
Human eotaxin induces eosinophil extravasation through rat mesenteric venules: role of alpha4 integrins and vascular cell adhesion molecule-1.
Immunology 1999;96(2):176-83.
1998: Ian Sabroe; Dolores M Conroy; Norma P Gerard; Y Li; PD Collins; T W Post; Peter J Jose; Timothy J Williams; Craig Gerard; Paul D Ponath
Cloning and characterization of the guinea pig eosinophil eotaxin receptor, C-C chemokine receptor-3: blockade using a monoclonal antibody in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):6139-47.
1998: Roger Palframan; PD Collins; N J Severs; Stephen Rothery; Timothy J Williams; Sara M Rankin
Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: the role of specific adhesion molecules and phosphatidylinositol 3-kinase.
The Journal of experimental medicine 1998;188(9):1621-32.
1998: Carlton Evans; H H Garcia; Adele Hartnell; Robert H Gilman; Peter J Jose; M Martinez; D G Remick; Timothy J Williams; Jon S Friedland
Elevated concentrations of eotaxin and interleukin-5 in human neurocysticercosis.
Infection and immunity 1998;66(9):4522-5.
1998: Maria-Jesus Sanz; Paul D Ponath; CR Mackay; W Newman; M Miyasaka; T Tamatani; B F Flanagan; Roy R Lobb; Timothy J Williams; Sussan Nourshargh; Peter J Jose
Human eotaxin induces alpha 4 and beta 2 integrin-dependent eosinophil accumulation in rat skin in vivo: delayed generation of eotaxin in response to IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3569-76.
1998: Roger Palframan; PD Collins; Timothy J Williams; Sara M Rankin
Eotaxin induces a rapid release of eosinophils and their progenitors from the bone marrow.
Blood 1998;91(7):2240-8.
1998: BT Au; Mauro Teixeira; PD Collins; Timothy J Williams
Effect of PDE4 inhibitors on zymosan-induced IL-8 release from human neutrophils: synergism with prostanoids and salbutamol.
British journal of pharmacology 1998;123(6):1260-6.
1997: Sun Ying; Douglas S Robinson; Qiu Meng; J Rottman; R Kennedy; Douglas J Ringler; CR Mackay; Bruce L Daugherty; Martin S Springer; Stephen R Durham; Timothy J Williams; A Barry Kay
Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells.
European journal of immunology 1997;27(12):3507-16.
1997: Mauro Teixeira; Timothy Wells; Nicholas W Lukacs; A E Proudfoot; Steven Kunkel; Timothy J Williams; Paul G Hellewell
Chemokine-induced eosinophil recruitment. Evidence of a role for endogenous eotaxin in an in vivo allergy model in mouse skin.
The Journal of clinical investigation 1997;100(7):1657-66.
1997: D Li; D Wang; DA Griffiths-Johnson; Timothy Wells; Timothy J Williams; Peter J Jose; Peter K Jeffery
Eotaxin protein and gene expression in guinea-pig lungs: constitutive expression and upregulation after allergen challenge.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1997;10(9):1946-54.
1997: Alison A Humbles; Dolores M Conroy; S Marleau; Sara M Rankin; Roger Palframan; A E Proudfoot; Timothy Wells; D Li; Peter K Jeffery; DA Griffiths-Johnson; Timothy J Williams; Peter J Jose
Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: analysis in a guinea pig model in vivo.
The Journal of experimental medicine 1997;186(4):601-12.
1997: Jane A Mitchell; F M Williams; Timothy J Williams; Simon Larkin
Role of nitric oxide in the dilator actions of capsaicin-sensitive nerves in the rabbit coronary circulation.
Neuropeptides 1997;31(4):333-8.
1997: K E Norman; Timothy J Williams; A G Rossi
Comparison of the reversed passive Arthus and local Shwartzman reactions of rabbit skin: effects of the long-acting PAF antagonist UK-74,505.
British journal of pharmacology 1997;120(7):1286-93.
1997: K Rajakulasingam; Qutayba Hamid; F O'Brien; E Shotman; Peter J Jose; Timothy J Williams; M Jacobson; Julia Barkans; Stephen R Durham
RANTES in human allergen-induced rhinitis: cellular source and relation to tissue eosinophilia.
American journal of respiratory and critical care medicine 1997;155(2):696-703.
1997: Ian Sabroe; Timothy J Williams; C A Hébert; PD Collins
Chemoattractant cross-desensitization of the human neutrophil IL-8 receptor involves receptor internalization and differential receptor subtype regulation.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1361-9.
1997: Dolores M Conroy; Alison A Humbles; Sara M Rankin; Roger Palframan; PD Collins; DA Griffiths-Johnson; Peter J Jose; Timothy J Williams
The role of the eosinophil-selective chemokine, eotaxin, in allergic and non-allergic airways inflammation.
Memórias do Instituto Oswaldo Cruz 1997;92 Suppl 2():183-91.
1997: DA Griffiths-Johnson; PD Collins; Peter J Jose; Timothy J Williams
Animal models of asthma: role of chemokines.
Methods in enzymology 1997;288():241-66.
1996: S Marleau; DA Griffiths-Johnson; PD Collins; Y S Bakhle; Timothy J Williams; Peter J Jose
Human RANTES acts as a receptor antagonist for guinea pig eotaxin in vitro and in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(9):4141-6.
1996: M W Wakelin; Maria-Jesus Sanz; A Dewar; S M Albelda; Simon Larkin; N Boughton-Smith; Timothy J Williams; Sussan Nourshargh
An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane.
The Journal of experimental medicine 1996;184(1):229-39.
1996: Mauro Teixeira; Timothy J Williams; P G Hellewell
Effects of dexamethasone and cyclosporin A on the accumulation of eosinophils in acute cutaneous inflammation in the guinea-pig.
British journal of pharmacology 1996;118(2):317-24.
1996: K E Norman; Timothy J Williams; Eugene Eyo Akujuru; A G Rossi
Effect of soluble P55 tumour-necrosis factor binding fusion protein on the local Shwartzman and Arthus reactions.
British journal of pharmacology 1996;117(3):471-478.
1995: Mauro Teixeira; Timothy J Williams; P G Hellewell
Mechanisms and pharmacological manipulation of eosinophil accumulation in vivo.
Trends in pharmacological sciences 1995;16(12):418-23.
1995: Jane A Mitchell; Simon Larkin; Timothy J Williams
Cyclooxygenase-2: regulation and relevance in inflammation.
Biochemical pharmacology 1995;50(10):1535-42.
1995: PD Collins; S Marleau; DA Griffiths-Johnson; Peter J Jose; Timothy J Williams
Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo.
The Journal of experimental medicine 1995;182(4):1169-74.
1995: N Berkman; Peter J Jose; Timothy J Williams; T J Schall; Peter J Barnes; K Fan Chung
Corticosteroid inhibition of macrophage inflammatory protein-1 alpha in human monocytes and alveolar macrophages.
The American journal of physiology 1995;269(4 Pt 1):L443-52.
1995: C L Ivey; F M Williams; PD Collins; Peter J Jose; Timothy J Williams
Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit. Evidence for a role for C5a and interleukin-8.
The Journal of clinical investigation 1995;95(6):2720-8.
1995: Sussan Nourshargh; Simon Larkin; A Das; Timothy J Williams
Interleukin-1-induced leukocyte extravasation across rat mesenteric microvessels is mediated by platelet-activating factor.
Blood 1995;85(9):2553-8.
1995: O J Kwon; Peter J Jose; R A Robbins; T J Schall; Timothy J Williams; Peter J Barnes
Glucocorticoid inhibition of RANTES expression in human lung epithelial cells.
American journal of respiratory cell and molecular biology 1995;12(5):488-96.
1995: D T Walsh; V B Weg; Timothy J Williams; Sussan Nourshargh
Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators.
British journal of pharmacology 1995;114(7):1343-50.
1995: Mauro Teixeira; Timothy J Williams; B T Au; P G Hellewell; A G Rossi
Characterization of eosinophil homotypic aggregation.
Journal of leukocyte biology 1995;57(2):226-34.
1995: Mauro Teixeira; Timothy J Williams; P G Hellewell
Anti-inflammatory effects of a short-acting and a long-acting beta 2-adrenoceptor agonist in guinea pig skin.
European journal of pharmacology 1995;272(2-3):185-93.
1995: V B Weg; D T Walsh; L H Faccioli; Timothy J Williams; Eugene Eyo Akujuru; Sussan Nourshargh
LPS-induced 111In-eosinophil accumulation in guinea-pig skin: evidence for a role for TNF-alpha.
Immunology 1995;84(1):36-40.
1995: Simon Larkin; L Fraser; H J Showell; Timothy J Williams; John Bowen Warren
Prolonged microvascular vasodilation induced by leukotriene B4 in human skin is cyclooxygenase independent.
The Journal of pharmacology and experimental therapeutics 1995;272(1):392-8.
1995: Timothy J Williams; DA Griffiths-Johnson; Peter J Jose; PD Collins
Eosinophil chemoattractants generated in vivo.
Agents and actions. Supplements 1995;46():1-9.
1995: A M Das; Timothy J Williams; Roy R Lobb; Sussan Nourshargh
Lung eosinophilia is dependent on IL-5 and the adhesion molecules CD18 and VLA-4, in a guinea-pig model.
Immunology 1995;84(1):41-6.
1994: Mauro Teixeira; S M Fairbairn; K E Norman; Timothy J Williams; A G Rossi; P G Hellewell
Studies on the mechanisms involved in the inflammatory response in a reversed passive Arthus reaction in guinea-pig skin: contribution of neutrophils and endogenous mediators.
British journal of pharmacology 1994;113(4):1363-71.
1994: Peter J Jose; I M Adcock; DA Griffiths-Johnson; N Berkman; Timothy Wells; Timothy J Williams; C A Power
Eotaxin: cloning of an eosinophil chemoattractant cytokine and increased mRNA expression in allergen-challenged guinea-pig lungs.
Biochemical and biophysical research communications 1994;205(1):788-94.
1994: Maria-Jesus Sanz; V B Weg; D T Walsh; Timothy J Williams; Sussan Nourshargh
Differential effects of the PAF receptor antagonist UK-74,505 on neutrophil and eosinophil accumulation in guinea-pig skin.
British journal of pharmacology 1994;113(2):513-21.
1994: V B Weg; Malcolm Watson; L H Faccioli; Timothy J Williams
Investigation of the endogenous chemoattractants involved in 111In-eosinophil accumulation in passive cutaneous anaphylactic reactions in the guinea-pig.
British journal of pharmacology 1994;113(1):35-42.
1994: F Pons; Timothy J Williams; S A Kirk; F McDonald; A G Rossi
Pro-inflammatory and anti-inflammatory effects of the stable prostaglandin D2 analogue, ZK 118.182.
European journal of pharmacology 1994;261(3):237-47.
1994: B T Au; Timothy J Williams; PD Collins
Zymosan-induced IL-8 release from human neutrophils involves activation via the CD11b/CD18 receptor and endogenous platelet-activating factor as an autocrine modulator.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(11):5411-9.
1994: V B Weg; Timothy J Williams
Chemical mediators and adhesion molecules involved in eosinophil accumulation in vivo.
Annals of the New York Academy of Sciences 1994;725():146-55.
1994: Mauro Teixeira; A G Rossi; Timothy J Williams; P G Hellewell
Effects of phosphodiesterase isoenzyme inhibitors on cutaneous inflammation in the guinea-pig.
British journal of pharmacology 1994;112(1):332-40.
1994: F M Williams; M Kus; K Tanda; Timothy J Williams
Effect of duration of ischaemia on reduction of myocardial infarct size by inhibition of neutrophil accumulation using an anti-CD18 monoclonal antibody.
British journal of pharmacology 1994;111(4):1123-8.
1994: Mauro Teixeira; S Reynia; M Robinson; A Shock; Timothy J Williams; F M Williams; A G Rossi; P G Hellewell
Role of CD18 in the accumulation of eosinophils and neutrophils and local oedema formation in inflammatory reactions in guinea-pig skin.
British journal of pharmacology 1994;111(3):811-8.
1994: Peter J Jose; DA Griffiths-Johnson; PD Collins; D T Walsh; Redwan Moqbel; Nick Totty; O Truong; J Justin Hsuan; Timothy J Williams
Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation.
The Journal of experimental medicine 1994;179(3):881-7.
1994: K E Norman; L W Argenbright; Timothy J Williams; A G Rossi
Role of adhesion glycoproteins CD18 and intercellular adhesion molecule-1 in complement-mediated reactions of rabbit skin.
British journal of pharmacology 1994;111(1):117-22.
1993: DA Griffiths-Johnson; PD Collins; A G Rossi; Peter J Jose; Timothy J Williams
The chemokine, eotaxin, activates guinea-pig eosinophils in vitro and causes their accumulation into the lung in vivo.
Biochemical and biophysical research communications 1993;197(3):1167-72.
1993: Mauro Teixeira; Timothy J Williams; P G Hellewell
Role of prostaglandins and nitric oxide in acute inflammatory reactions in guinea-pig skin.
British journal of pharmacology 1993;110(4):1515-21.
1993: F M Williams; K Tanda; M Kus; Timothy J Williams
Trimetazidine inhibits neutrophil accumulation after myocardial ischaemia and reperfusion in rabbits.
Journal of cardiovascular pharmacology 1993;22(6):828-33.
1993: Mauro Teixeira; Michael J Doenhoff; C McNeice; Timothy J Williams; P G Hellewell
Mechanisms of the inflammatory response induced by extracts of Schistosoma mansoni larvae in guinea pig skin.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(10):5525-34.
1993: Mauro Teixeira; Timothy J Williams; P G Hellewell
E-type prostaglandins enhance local oedema formation and neutrophil accumulation but suppress eosinophil accumulation in guinea-pig skin.
British journal of pharmacology 1993;110(1):416-22.
1993: F Pons; Timothy J Williams; John Bowen Warren
Nitric oxide, but not interleukin-1, mediates the local blood flow response to lipopolysaccharide in rabbit skin.
European journal of pharmacology 1993;239(1-3):23-30.
1993: Simon Larkin; Timothy J Williams
Evidence for sensory nerve involvement in cutaneous reactive hyperemia in humans.
Circulation research 1993;73(1):147-54.
1993: PD Collins; V B Weg; L H Faccioli; Malcolm Watson; Redwan Moqbel; Timothy J Williams
Eosinophil accumulation induced by human interleukin-8 in the guinea-pig in vivo.
Immunology 1993;79(2):312-8.
1993: F Pons; A G Rossi; K E Norman; Timothy J Williams; Sussan Nourshargh
Role of platelet-activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long-acting PAF antagonist, UK-74,505.
British journal of pharmacology 1993;109(1):234-42.
1993: PD Collins; D T Connolly; Timothy J Williams
Characterization of the increase in vascular permeability induced by vascular permeability factor in vivo.
British journal of pharmacology 1993;109(1):195-9.
1993: H Yarwood; Sussan Nourshargh; S Brain; Timothy J Williams
Effect of dexamethasone on neutrophil accumulation and oedema formation in rabbit skin: an investigation of site of action.
British journal of pharmacology 1993;108(4):959-66.
1993: V B Weg; Timothy J Williams; Roy R Lobb; Sussan Nourshargh
A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo.
The Journal of experimental medicine 1993;177(2):561-6.
1992: C von Uexküll; Sussan Nourshargh; Timothy J Williams
Comparative responses of human and rabbit interleukin-1 in vivo: effect of a recombinant interleukin-1 receptor antagonist.
Immunology 1992;77(4):483-7.
1992: P G Hellewell; Peter J Jose; Timothy J Williams
Inflammatory mechanisms in the passive cutaneous anaphylactic reaction in the rabbit: evidence that novel mediators are involved.
British journal of pharmacology 1992;107(4):1163-72.
1992: A G Rossi; K E Norman; D Donigi-Gale; T S Shoupe; R Edwards; Timothy J Williams
The role of complement, platelet-activating factor and leukotriene B4 in a reversed passive Arthus reaction.
British journal of pharmacology 1992;107(1):44-9.
1992: John Bowen Warren; M L Coughlan; Timothy J Williams
Endotoxin-induced vasodilatation in anaesthetized rat skin involves nitric oxide and prostaglandin synthesis.
British journal of pharmacology 1992;106(4):953-7.
1992: T L Buckley; S D Brain; Peter J Jose; Timothy J Williams
The partial inhibition of inflammatory responses induced by capsaicin using the Fab fragment of a selective calcitonin gene-related peptide antiserum in rabbit skin.
Neuroscience 1992;48(4):963-8.
1992: John Bowen Warren; Simon Larkin; M Coughlan; R Kajekar; Timothy J Williams
Pituitary adenylate cyclase activating polypeptide is a potent vasodilator and oedema potentiator in rabbit skin in vivo.
British journal of pharmacology 1992;106(2):331-4.
1992: Sussan Nourshargh; J A Perkins; H J Showell; K Matsushima; Timothy J Williams; PD Collins
A comparative study of the neutrophil stimulatory activity in vitro and pro-inflammatory properties in vivo of 72 amino acid and 77 amino acid IL-8.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(1):106-11.
1991: V B Weg; Malcolm Watson; Renato S B Cordeiro; Timothy J Williams
Histamine, leukotriene D4 and platelet-activating factor in guinea pig passive cutaneous anaphylaxis.
European journal of pharmacology 1991;204(2):157-63.
1991: Peter J Jose; PD Collins; J A Perkins; B C Beaubien; Nick Totty; M D Waterfield; J Justin Hsuan; Timothy J Williams
Identification of a second neutrophil-chemoattractant cytokine generated during an inflammatory reaction in the rabbit peritoneal cavity in vivo. Purification, partial amino acid sequence and structural relationship to melanoma-growth-stimulatory activity.
The Biochemical journal 1991;278 ( Pt 2)():493-7.
1991: J P Seale; Sussan Nourshargh; P G Hellewell; Timothy J Williams
Mechanism of action of platelet activating factor in the pulmonary circulation: an investigation using a novel isotopic system in rabbit isolated lung.
British journal of pharmacology 1991;104(1):251-7.
1991: T L Buckley; S D Brain; M Rampart; Timothy J Williams
Time-dependent synergistic interactions between the vasodilator neuropeptide, calcitonin gene-related peptide (CGRP) and mediators of inflammation.
British journal of pharmacology 1991;103(2):1515-9.
1991: L H Faccioli; Sussan Nourshargh; Redwan Moqbel; F M Williams; R Sehmi; A Barry Kay; Timothy J Williams
The accumulation of 111In-eosinophils induced by inflammatory mediators, in vivo.
Immunology 1991;73(2):222-7.
1991: T L Buckley; S D Brain; PD Collins; Timothy J Williams
Inflammatory edema induced by interactions between IL-1 and the neuropeptide calcitonin gene-related peptide.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(10):3424-30.
1991: PD Collins; Peter J Jose; Timothy J Williams
The sequential generation of neutrophil chemoattractant proteins in acute inflammation in the rabbit in vivo. Relationship between C5a and proteins with the characteristics of IL-8/neutrophil-activating protein 1.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(2):677-84.
1991: Timothy J Williams; A Das; C von Uexkull; Sussan Nourshargh
Neutrophils in asthma.
Annals of the New York Academy of Sciences 1991;629():73-81.
1991: Malcolm Watson; Timothy J Williams
Measurement of cell accumulation.
Agents and actions. Supplements 1991;34():429-38.
1990: B C Beaubien; PD Collins; Peter J Jose; Nick Totty; J Justin Hsuan; M D Waterfield; Timothy J Williams
A novel neutrophil chemoattractant generated during an inflammatory reaction in the rabbit peritoneal cavity in vivo. Purification, partial amino acid sequence and structural relationship to interleukin 8.
The Biochemical journal 1990;271(3):797-801.
1990: Sussan Nourshargh; Timothy J Williams
Evidence that a receptor-operated event on the neutrophil mediates neutrophil accumulation in vivo. Pretreatment of 111In-neutrophils with pertussis toxin in vitro inhibits their accumulation in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(8):2633-8.
1990: Peter J Jose; I K Moss; R N Maini; Timothy J Williams
Measurement of the chemotactic complement fragment C5a in rheumatoid synovial fluids by radioimmunoassay: role of C5a in the acute inflammatory phase.
Annals of the rheumatic diseases 1990;49(10):747-52.
1990: F M Williams; PD Collins; M Tannière-Zeller; Timothy J Williams
The relationship between neutrophils and increased microvascular permeability in a model of myocardial ischaemia and reperfusion in the rabbit.
British journal of pharmacology 1990;100(4):729-34.
1990: S D Brain; S Wimalawansa; I MacIntyre; Timothy J Williams
The demonstration of vasodilator activity of pancreatic amylin amide in the rabbit.
The American journal of pathology 1990;136(3):487-90.
1990: T L Buckley; S D Brain; Timothy J Williams
Ruthenium red selectively inhibits oedema formation and increased blood flow induced by capsaicin in rabbit skin.
British journal of pharmacology 1990;99(1):7-8.
1989: P G Hellewell; Timothy J Williams
Antagonism of Paf-induced oedema formation in rabbit skin: a comparison of different antagonists.
British journal of pharmacology 1989;97(1):171-80.
1989: Sussan Nourshargh; M Rampart; P G Hellewell; Peter J Jose; J M Harlan; A J Edwards; Timothy J Williams
Accumulation of 111In-neutrophils in rabbit skin in allergic and non-allergic inflammatory reactions in vivo. Inhibition by neutrophil pretreatment in vitro with a monoclonal antibody recognizing the CD18 antigen.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(9):3193-8.
1989: P G Hellewell; H Yarwood; Timothy J Williams
Characteristics of oedema formation induced by N-formyl-methionyl-leucyl-phenylalanine in rabbit skin.
British journal of pharmacology 1989;97(1):181-9.
1989: S D Brain; Timothy J Williams
Interactions between the tachykinins and calcitonin gene-related peptide lead to the modulation of oedema formation and blood flow in rat skin.
British journal of pharmacology 1989;97(1):77-82.
1989: P G Hellewell; Timothy J Williams
An anti-inflammatory steroid inhibits tissue sensitization by IgE in vivo.
British journal of pharmacology 1989;96(1):5-7.
1989: M Rampart; Peter J Jose; Timothy J Williams
Rabbit leukocytes activated by C5a des Arg and N-formyl-methionyl-leucyl-phenylalanine promote endothelial prostacyclin production. Evidence for a role of hydrogen peroxide.
Eicosanoids 1989;2(2):109-15.
1989: S D Brain; D C Crossman; T L Buckley; Timothy J Williams
Endothelin-1: demonstration of potent effects on the microcirculation of humans and other species.
Journal of cardiovascular pharmacology 1989;13 Suppl 5():S147-9; discussion S150.
1988: S D Brain; J R Tippins; Timothy J Williams
Endothelin induces potent microvascular constriction.
British journal of pharmacology 1988;95(4):1005-7.
1988: S D Brain; Timothy J Williams
Neuropharmacology of peptides in skin.
Seminars in dermatology 1988;7(4):278-83.
1988: L Needham; P G Hellewell; Timothy J Williams; J L Gordon
Endothelial functional responses and increased vascular permeability induced by polycations.
Laboratory investigation; a journal of technical methods and pathology 1988;59(4):538-48.
1988: S D Brain; Timothy J Williams
Substance P regulates the vasodilator activity of calcitonin gene-related peptide.
Nature 1988;335(6185):73-5.
1988: Timothy J Williams; S D Brain; P G Hellewell; Peter J Jose; Sussan Nourshargh; M Rampart
Alteration in microvascular permeability induced by products released during inflammation.
Progress in clinical and biological research 1988;263():55-69.
1985: M Rampart; Peter J Jose; Timothy J Williams
Leucocytes activated by C5a des Arg promote endothelial prostacyclin (PGI2) production via release of oxygen species in vitro.
Agents and actions 1985;16(1-2):21-2.