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Theresa Williams

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Meiqing Lu; Georgia B McGaughey; PM McKenna; Michael D Miller; Sanjeev Munshi; Vandna Munshi; Ying-Jie Wang; Theresa M Williams; Youwei Yan; Neville J Anthony; Peter J Felock; Robert Gomez; Jay A Grobler; Daria J Hazuda; Renee C Hrin; Ming-Tain Lai
Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor.
Sophie Parmentier-Batteur; Jason M Uslaner; Theresa M Williams; Julie A O'Brien; Hank Chen; Scott Doran; Eleftheria N Finger; Rosemarie Beth Flick; Marlene A Jacobson; Shannon J Nguyen; Pete H Hutson
Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration.
C Blair Zartman; Ian M Bell; Steven N Gallicchio; Samuel L Graham; Stefanie A Kane; John J Mallee; Ruth Z Rutledge; Christopher A Salvatore; Joseph P Vacca; Theresa M Williams
Identification of a novel RAMP-independent CGRP receptor antagonist.

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2012: Meiqing Lu; Georgia B McGaughey; PM McKenna; Michael D Miller; Sanjeev Munshi; Vandna Munshi; Ying-Jie Wang; Theresa M Williams; Youwei Yan; Neville J Anthony; Peter J Felock; Robert Gomez; Jay A Grobler; Daria J Hazuda; Renee C Hrin; Ming-Tain Lai
Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor.
Antimicrobial agents and chemotherapy 2012;56(6):3324-35.
2012: Sophie Parmentier-Batteur; Jason M Uslaner; Theresa M Williams; Julie A O'Brien; Hank Chen; Scott Doran; Eleftheria N Finger; Rosemarie Beth Flick; Marlene A Jacobson; Shannon J Nguyen; Pete H Hutson
Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration.
Neuropharmacology 2012;62(3):1453-60.
2011: C Blair Zartman; Ian M Bell; Steven N Gallicchio; Samuel L Graham; Stefanie A Kane; John J Mallee; Ruth Z Rutledge; Christopher A Salvatore; Joseph P Vacca; Theresa M Williams
Identification of a novel RAMP-independent CGRP receptor antagonist.
Bioorganic & medicinal chemistry letters 2011;21(22):6705-8.
2011: Sophie Parmentier-Batteur; Hemaka A Rajapakse; Christopher P Regan; Ian J Reynolds; John M Sanders; Sujata Sharma; Joseph P Vacca; Theresa M Williams; Hong Zhu; Eleftheria N Finger; J Fred Hess; Kandpal Geeta; Raghu Krishnan; Robert J Mark; Keith P Moore; Philippe G Nantermet
Attenuation of scratch-induced reactive astrogliosis by novel EphA4 kinase inhibitors.
Journal of neurochemistry 2011;118(6):1016-31.
2011: Daniel V Paone; Diem N Nguyen; Anthony W Shaw; Christopher S Burgey; Craig M Potteiger; James Z Deng; Scott D Mosser; Christopher A Salvatore; Sean Yu; Shane Roller; Stefanie A Kane; Harold G Selnick; Joseph P Vacca; Theresa M Williams
Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: discovery of MK-2918.
Bioorganic & medicinal chemistry letters 2011;21(9):2683-6.
2011: Hemaka A Rajapakse; Abbas M Walji; Keith P Moore; Hong Zhu; Aurpon W Mitra; Alison R Gregro; Elizabeth Tinney; Christine Burlein; Sinoeun Touch; Brenda L Paton; Steven S Carroll; Daniel J DiStefano; Ming-Tain Lai; Jay A Grobler; Rosa I Sanchez; Theresa M Williams; Joseph P Vacca; Philippe G Nantermet
Strategies towards improving the pharmacokinetic profile of ε-substituted lysinol-derived HIV protease inhibitors.
ChemMedChem 2011;6(2):253-7.
2010: Ming-Tain Lai; Meiqing Lu; Peter J Felock; Renee C Hrin; Ying-Jie Wang; Youwei Yan; Sanjeev Munshi; Georgia B McGaughey; Robert M Tynebor; Thomas J Tucker; Theresa M Williams; Jay A Grobler; Daria J Hazuda; PM McKenna; Michael D Miller
Distinct mutation pathways of non-subtype B HIV-1 during in vitro resistance selection with nonnucleoside reverse transcriptase inhibitors.
Antimicrobial agents and chemotherapy 2010;54(11):4812-24.
2010: Dai-Shi Su; John J Lim; Elizabeth Tinney; Thomas J Tucker; Sandeep Saggar; John T Sisko; Bang-Lin Wan; Mary Beth Young; Kenneth D Anderson; Deanne Rudd; Vandna Munshi; Carolyn Bahnck; Peter J Felock; Meiquing Lu; Ming-Tain Lai; Sinoeun Touch; Gregory Moyer; Daniel J Distefano; Jessica A Flynn; Yuexia Liang; Rosa Sanchez; Rebecca Perlow-Poehnelt; Mike Miller; Joseph P Vacca; Theresa M Williams; Neville J Anthony
Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif.
Bioorganic & medicinal chemistry letters 2010;20(15):4328-32.
2010: Kristen L G Jones; M Katharine Holloway; Hua-Poo Su; Steven S Carroll; Christine Burlein; Sinoeun Touch; Daniel J DiStefano; Rosa I Sanchez; Theresa M Williams; Joseph P Vacca; Craig A Coburn
Epsilon substituted lysinol derivatives as HIV-1 protease inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(14):4065-8.
2010: Craig A Stump; Ian M Bell; Rodney A Bednar; John F Fay; Steven N Gallicchio; James C Hershey; Richard Jelley; Constantine Kreatsoulas; Eric L Moore; Scott D Mosser; Amy G Quigley; Shane A Roller; Christopher A Salvatore; Steven S Sharik; Cory R Theberge; C Blair Zartman; Stefanie A Kane; Samuel L Graham; Harold G Selnick; Joseph P Vacca; Theresa M Williams
Identification of potent, highly constrained CGRP receptor antagonists.
Bioorganic & medicinal chemistry letters 2010;20(8):2572-6.
2009: Dai-Shi Su; John J Lim; Elizabeth Tinney; Bang-Lin Wan; Mary Beth Young; Kenneth D Anderson; Deanne Rudd; Vandna Munshi; Carolyn Bahnck; Peter J Felock; Meiquing Lu; Ming-Tain Lai; Sinoeun Touch; Gregory Moyer; Daniel J DiStefano; Jessica A Flynn; Yuexia Liang; Rosa Sanchez; Rebecca Perlow-Poehnelt; Mike Miller; Joseph P Vacca; Theresa M Williams; Neville J Anthony
Biaryl ethers as novel non-nucleoside reverse transcriptase inhibitors with improved potency against key mutant viruses.
Journal of medicinal chemistry 2009;52(22):7163-9.
2009: Christopher S Burgey; Craig M Potteiger; James Z Deng; Scott D Mosser; Christopher A Salvatore; Sean Yu; Shane Roller; Stefanie A Kane; Joseph P Vacca; Theresa M Williams
Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines.
Bioorganic & medicinal chemistry letters 2009;19(22):6368-72.
2009: Dai-Shi Su; John J Lim; Elizabeth Tinney; Bang-Lin Wan; Mary Beth Young; Kenneth D Anderson; Deanne Rudd; Vandna Munshi; Carolyn Bahnck; Peter J Felock; Meiqing Lu; Ming-Tain Lai; Sinoeun Touch; Gregory Moyer; Daniel J Distefano; Jessica A Flynn; Yuexia Liang; Rosa Sanchez; Sridhar Prasad; Youwei Yan; Rebecca Perlow-Poehnelt; Maricel Torrent; Mike Miller; Joseph P Vacca; Theresa M Williams; Neville J Anthony
Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants.
Bioorganic & medicinal chemistry letters 2009;19(17):5119-23.
2009: Ian M Bell; Rodney A Bednar; Halea A Corcoran; John F Fay; Steven N Gallicchio; Victor K Johnston; James C Hershey; Cynthia Miller-Stein; Eric L Moore; Scott D Mosser; Shane A Roller; Christopher A Salvatore; Cory R Theberge; Bradley K Wong; C Blair Zartman; Stefanie A Kane; Theresa M Williams; Samuel L Graham; Joseph P Vacca
The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists.
Bioorganic & medicinal chemistry letters 2009;19(16):4740-2.
2009: Ming-Tain Lai; Vandna Munshi; Sinoeun Touch; Robert M Tynebor; Thomas J Tucker; PM McKenna; Theresa M Williams; Daniel J DiStefano; Daria J Hazuda; Michael D Miller
Antiviral activity of MK-4965, a novel nonnucleoside reverse transcriptase inhibitor.
Antimicrobial agents and chemotherapy 2009;53(6):2424-31.
2009: Theresa M Williams; Christopher S Burgey; Christopher A Salvatore
Calcitonin gene-related peptide receptor antagonists for the treatment of migraine.
Progress in medicinal chemistry 2009;47():1-35.
2009: Craig A Stump; Ian M Bell; Rodney A Bednar; Joseph G Bruno; John F Fay; Steven N Gallicchio; Victor K Johnston; Eric L Moore; Scott D Mosser; Amy G Quigley; Christopher A Salvatore; Cory R Theberge; C Blair Zartman; Xu-Fang Zhang; Stefanie A Kane; Samuel L Graham; Joseph P Vacca; Theresa M Williams
The discovery of highly potent CGRP receptor antagonists.
Bioorganic & medicinal chemistry letters 2009;19(1):214-7.
2008: Cory R Theberge; Rodney A Bednar; Ian M Bell; Halea A Corcoran; John F Fay; James C Hershey; Victor K Johnston; Stefanie A Kane; Scott Mosser; Christopher A Salvatore; Theresa M Williams; C Blair Zartman; Xu-Fang Zhang; Samuel L Graham; Joseph P Vacca
Potent benzimidazolone-based CGRP receptor antagonists.
Bioorganic & medicinal chemistry letters 2008;18(23):6122-5.
2008: Thomas J Tucker; John T Sisko; Robert M Tynebor; Theresa M Williams; Peter J Felock; Jessica A Flynn; Ming-Tain Lai; Yuexia Liang; Georgia B McGaughey; Meiquing Liu; Mike Miller; Gregory Moyer; Vandna Munshi; Rebecca Perlow-Poehnelt; Sridhar Prasad; John C Reid; Rosa Sanchez; Maricel Torrent; Joseph P Vacca; Bang-Lin Wan; Youwei Yan
Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses.
Journal of medicinal chemistry 2008;51(20):6503-11.
2008: Christopher S Burgey; Daniel V Paone; Anthony W Shaw; James Z Deng; Diem N Nguyen; Craig M Potteiger; Samuel L Graham; Joseph P Vacca; Theresa M Williams
Synthesis of the (3R,6S)-3-amino-6-(2,3-difluorophenyl)azepan-2-one of telcagepant (MK-0974), a calcitonin gene-related peptide receptor antagonist for the treatment of migraine headache.
Organic letters 2008;10(15):3235-8.
2008: Thomas J Tucker; Sandeep Saggar; John T Sisko; Robert M Tynebor; Theresa M Williams; Peter J Felock; Jessica A Flynn; Ming-Tain Lai; Yuexia Liang; Georgia B McGaughey; Meiquing Liu; Mike Miller; Gregory Moyer; Vandna Munshi; Rebecca Perlow-Poehnelt; Sridhar Prasad; Rosa Sanchez; Maricel Torrent; Joseph P Vacca; Bang-Lin Wan; Youwei Yan
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations.
Bioorganic & medicinal chemistry letters 2008;18(9):2959-66.
2008: Christopher A Salvatore; James C Hershey; Halea A Corcoran; John F Fay; Victor K Johnston; Eric L Moore; Scott D Mosser; Christopher S Burgey; Daniel V Paone; Anthony W Shaw; Samuel L Graham; Joseph P Vacca; Theresa M Williams; Kenneth S Koblan; Stefanie A Kane
Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine.
The Journal of pharmacology and experimental therapeutics 2008;324(2):416-21.
2008: Diem N Nguyen; Daniel V Paone; Anthony W Shaw; Christopher S Burgey; Scott D Mosser; Victor Johnston; Christopher A Salvatore; Yvonne M Leonard; Cynthia Miller-Stein; Stefanie A Kane; Kenneth S Koblan; Joseph P Vacca; Samuel L Graham; Theresa M Williams
Calcitonin gene-related peptide (CGRP) receptor antagonists: investigations of a pyridinone template.
Bioorganic & medicinal chemistry letters 2008;18(2):755-8.
2007: Daniel V Paone; Anthony W Shaw; Diem N Nguyen; Christopher S Burgey; James Z Deng; Stefanie A Kane; Kenneth S Koblan; Christopher A Salvatore; Scott D Mosser; Victor K Johnston; Bradley K Wong; Cynthia Miller-Stein; James C Hershey; Samuel L Graham; Joseph P Vacca; Theresa M Williams
Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974).
Journal of medicinal chemistry 2007;50(23):5564-7.
2007: Anthony W Shaw; Daniel V Paone; Diem N Nguyen; Craig A Stump; Christopher S Burgey; Scott D Mosser; Christopher A Salvatore; Ruth Z Rutledge; Stefanie A Kane; Kenneth S Koblan; Samuel L Graham; Joseph P Vacca; Theresa M Williams
Caprolactams as potent CGRP receptor antagonists for the treatment of migraine.
Bioorganic & medicinal chemistry letters 2007;17(17):4795-8.
2006: Ian M Bell; Rodney A Bednar; John F Fay; Steven N Gallicchio; Jerome H Hochman; Daniel R McMasters; Cynthia Miller-Stein; Eric L Moore; Scott D Mosser; Nicole T Pudvah; Amy G Quigley; Christopher A Salvatore; Craig A Stump; Cory R Theberge; Bradley K Wong; C Blair Zartman; Xu-Fang Zhang; Stefanie A Kane; Samuel L Graham; Joseph P Vacca; Theresa M Williams
Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists.
Bioorganic & medicinal chemistry letters 2006;16(24):6165-9.
2006: Christopher S Burgey; Craig A Stump; Diem N Nguyen; James Z Deng; Amy G Quigley; Beth R Norton; Ian M Bell; Scott D Mosser; Christopher A Salvatore; Ruth Z Rutledge; Stefanie A Kane; Kenneth S Koblan; Joseph P Vacca; Samuel L Graham; Theresa M Williams
Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: optimization of the 4-substituted piperidine.
Bioorganic & medicinal chemistry letters 2006;16(19):5052-6.
2006: Theresa M Williams; Craig A Stump; Diem N Nguyen; Amy G Quigley; Ian M Bell; Steven N Gallicchio; C Blair Zartman; Bang-Lin Wan; Kimberly Della Penna; Priya Kunapuli; Stefanie A Kane; Kenneth S Koblan; Scott D Mosser; Ruth Z Rutledge; Christopher A Salvatore; John F Fay; Joseph P Vacca; Samuel L Graham
Non-peptide calcitonin gene-related peptide receptor antagonists from a benzodiazepinone lead.
Bioorganic & medicinal chemistry letters 2006;16(10):2595-8.
2006: Christopher A Salvatore; John J Mallee; Ian M Bell; C Blair Zartman; Theresa M Williams; Kenneth S Koblan; Stefanie A Kane
Identification and pharmacological characterization of domains involved in binding of CGRP receptor antagonists to the calcitonin-like receptor.
Biochemistry 2006;45(6):1881-7.
2005: Ian M Bell; Steven M Stirdivant; Janet Ahern; J Christopher Culberson; Paul L Darke; Christopher Dinsmore; Robert A Drakas; Steven N Gallicchio; Samuel L Graham; David C Heimbrook; Dawn L Hall; Jin Hua; Nathan R Kett; Annette S Kim; Maria Kornienko; Lawrence C Kuo; Sanjeev Munshi; Amy G Quigley; John C Reid; Wes Trotter; Lloyd H Waxman; Theresa M Williams; C Blair Zartman
Biochemical and structural characterization of a novel class of inhibitors of the type 1 insulin-like growth factor and insulin receptor kinases.
Biochemistry 2005;44(27):9430-40.
2005: James C Hershey; Halea A Corcoran; Elizabeth P Baskin; Christopher A Salvatore; Scott D Mosser; Theresa M Williams; Kenneth S Koblan; Richard Hargreaves; Stefanie A Kane
Investigation of the species selectivity of a nonpeptide CGRP receptor antagonist using a novel pharmacodynamic assay.
Regulatory peptides 2005;127(1-3):71-7.
2004: Christopher Dinsmore; C Blair Zartman; Jeffrey M Bergman; Marc T Abrams; Carolyn A Buser; J Christopher Culberson; Joseph P Davide; Michelle Ellis-Hutchings; Christine Fernandes; Samuel L Graham; George D Hartman; Hans E Huber; Robert B Lobell; Scott D Mosser; Ronald G Robinson; Theresa M Williams
Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.
Bioorganic & medicinal chemistry letters 2004;14(3):639-43.
2002: Diem N Nguyen; Craig A Stump; Eileen S Walsh; Christine Fernandes; Joseph P Davide; Michelle Ellis-Hutchings; Ronald G Robinson; Theresa M Williams; Robert B Lobell; Hans E Huber; Carolyn A Buser
Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I.
Bioorganic & medicinal chemistry letters 2002;12(9):1269-73.
2001: Robert B Lobell; CA Omer; Marc T Abrams; HG Bhimnathwala; MJ Brucker; Carolyn A Buser; Joseph P Davide; S Jane deSolms; Christopher Dinsmore; Michelle Ellis-Hutchings; AM Kral; Dongming Liu; William C Lumma; S V Machotka; Elaine Rands; Theresa M Williams; Samuel L Graham; George D Hartman; Allen Oliff; David C Heimbrook; Nancy E Kohl
Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
Cancer research 2001;61(24):8758-68.
2001: M Chiba; Cuyue Tang; William Neway; Theresa M Williams; S Jane deSolms; Christopher Dinsmore; John S Wai; Jiunn H Lin
P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes.
Biochemical pharmacology 2001;62(6):773-6.
2001: Ian M Bell; Steven N Gallicchio; M Abrams; Douglas C Beshore; Carolyn A Buser; J Christopher Culberson; Joseph P Davide; Michelle Ellis-Hutchings; Christine Fernandes; Jackson B Gibbs; Samuel L Graham; George D Hartman; David C Heimbrook; Carl F Homnick; Joel R Huff; Kelem Kassahun; Kenneth S Koblan; Nancy E Kohl; Robert B Lobell; Joseph J Lynch; P A Miller; CA Omer; A David Rodrigues; Eileen S Walsh; Theresa M Williams
Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.
Journal of medicinal chemistry 2001;44(18):2933-49.
2001: Douglas C Beshore; Ian M Bell; Christopher Dinsmore; Carl F Homnick; J Christopher Culberson; Ronald G Robinson; Christine Fernandes; Eileen S Walsh; Marc T Abrams; HG Bhimnathwala; Joseph P Davide; Michelle Ellis-Hutchings; H A Huber; Kenneth S Koblan; Carolyn A Buser; Nancy E Kohl; Robert B Lobell; I-Wu Chen; Debra McLoughlin; Timothy V Olah; Samuel L Graham; George D Hartman; Theresa M Williams
Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase.
Bioorganic & medicinal chemistry letters 2001;11(14):1817-21.
2001: Hans E Huber; Ronald G Robinson; A Watkins; D D Nahas; Marc T Abrams; Carolyn A Buser; Robert B Lobell; D Patrick; Neville J Anthony; Christopher Dinsmore; Samuel L Graham; George D Hartman; William C Lumma; Theresa M Williams; David C Heimbrook
Anions modulate the potency of geranylgeranyl-protein transferase I inhibitors.
The Journal of biological chemistry 2001;276(27):24457-65.
2001: Jeffrey M Bergman; Marc T Abrams; Joseph P Davide; IB Greenberg; Ronald G Robinson; Carolyn A Buser; Hans E Huber; Kenneth S Koblan; Nancy E Kohl; Robert B Lobell; Samuel L Graham; George D Hartman; Theresa M Williams; Christopher Dinsmore
Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.
Bioorganic & medicinal chemistry letters 2001;11(11):1411-5.
2001: Wes Trotter; Amy G Quigley; William C Lumma; John T Sisko; Eileen S Walsh; C S Hamann; Ronald G Robinson; HG Bhimnathwala; D G Kolodin; W Zheng; Carolyn A Buser; Hans E Huber; Robert B Lobell; Nancy E Kohl; Theresa M Williams; Samuel L Graham; Christopher Dinsmore
2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase.
Bioorganic & medicinal chemistry letters 2001;11(7):865-9.
2001: Christopher Dinsmore; Michael J Bogusky; J Christopher Culberson; Jeffrey M Bergman; Carl F Homnick; C Blair Zartman; Scott D Mosser; Michael D Schaber; Ronald G Robinson; Kenneth S Koblan; Hans E Huber; Samuel L Graham; George D Hartman; Joel R Huff; Theresa M Williams
Conformational restriction of flexible ligands guided by the transferred noe experiment: potent macrocyclic inhibitors of farnesyltransferase.
Journal of the American Chemical Society 2001;123(9):2107-8.
2001: Carolyn A Buser; Christopher Dinsmore; Christine Fernandes; IB Greenberg; Kelly Hamilton; Scott D Mosser; Eileen S Walsh; Theresa M Williams; Kenneth S Koblan
High-performance liquid chromatography/mass spectrometry characterization of Ki4B-Ras in PSN-1 cells treated with the prenyltransferase inhibitor L-778,123.
Analytical biochemistry 2001;290(1):126-37.
2001: Christopher Dinsmore; Jeffrey M Bergman; D D Wei; C Blair Zartman; Joseph P Davide; IB Greenberg; Dongming Liu; TJ O'Neill; Jackson B Gibbs; Kenneth S Koblan; Nancy E Kohl; Robert B Lobell; I-Wu Chen; Debra McLoughlin; Timothy V Olah; Samuel L Graham; George D Hartman; Theresa M Williams
Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase.
Bioorganic & medicinal chemistry letters 2001;11(4):537-40.
2000: Cuyue Tang; M Chiba; JA Nishime; Jerome H Hochman; I Chen; Theresa M Williams; Jiunn H Lin
Comparison of imidazole- and 2-methyl imidazole-containing farnesyl-protein transferase inhibitors: interaction with and metabolism by rat hepatic cytochrome P450s.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(6):680-6.
1999: Christopher Dinsmore; Theresa M Williams; TJ O'Neill; Dongming Liu; Elaine Rands; J Christopher Culberson; Robert B Lobell; Kenneth S Koblan; Nancy E Kohl; Jackson B Gibbs; Allen Oliff; Samuel L Graham; George D Hartman
Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase.
Bioorganic & medicinal chemistry letters 1999;9(23):3301-6.
1999: Theresa M Williams; Jeffrey M Bergman; Karen M Brashear; Michael J Breslin; Christopher Dinsmore; John H Hutchinson; Suzanne C MacTough; Craig A Stump; D D Wei; C Blair Zartman; Michael J Bogusky; J Christopher Culberson; Carolyn Buser-Doepner; Joseph P Davide; IB Greenberg; Kelly A Hamilton; Kenneth S Koblan; Nancy E Kohl; Dongming Liu; Robert B Lobell; Scott D Mosser; TJ O'Neill; Elaine Rands; Michael D Schaber; Joel R Huff
N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity.
Journal of medicinal chemistry 1999;42(19):3779-84.
1999: Terrence M Ciccarone; Suzanne C MacTough; Theresa M Williams; Christopher Dinsmore; TJ O'Neill; D Shah; J Christopher Culberson; Kenneth S Koblan; Nancy E Kohl; Jackson B Gibbs; Allen Oliff; Samuel L Graham; George D Hartman
Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase.
Bioorganic & medicinal chemistry letters 1999;9(14):1991-6.
1997: AM Kral; Ronald E Diehl; S Jane deSolms; Theresa M Williams; Nancy E Kohl; CA Omer
Mutational analysis of conserved residues of the beta-subunit of human farnesyl:protein transferase.
The Journal of biological chemistry 1997;272(43):27319-23.
1997: CA Omer; Neville J Anthony; Carolyn Buser-Doepner; A L Burkhardt; S Jane deSolms; Christopher Dinsmore; Jackson B Gibbs; George D Hartman; Kenneth S Koblan; Robert B Lobell; Allen Oliff; Theresa M Williams; Nancy E Kohl
Farnesyl: proteintransferase inhibitors as agents to inhibit tumor growth.
BioFactors (Oxford, England) 1997;6(3):359-66.
1996: Kenneth S Koblan; Nancy E Kohl; CA Omer; Neville J Anthony; M W Conner; S Jane deSolms; Theresa M Williams; Samuel L Graham; George D Hartman; Allen Oliff; Jackson B Gibbs
Farnesyltransferase inhibitors: a new class of cancer chemotherapeutics.
Biochemical Society transactions 1996;24(3):688-92.
1996: Theresa M Williams; T M Ciccarone; Suzanne C MacTough; R L Bock; M W Conner; J P Davide; K Hamilton; Kenneth S Koblan; Nancy E Kohl; AM Kral; Scott D Mosser; CA Omer; DL Pompliano; Elaine Rands; Michael D Schaber; D Shah; F R Wilson; Jackson B Gibbs; Samuel L Graham; George D Hartman; Allen Oliff; R L Smith
2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.
Journal of medicinal chemistry 1996;39(7):1345-8.
1996: Jackson B Gibbs; Nancy E Kohl; Kenneth S Koblan; CA Omer; Laura Sepp-Lorenzino; Neal Rosen; Neville J Anthony; M W Conner; S Jane deSolms; Theresa M Williams; Samuel L Graham; George D Hartman; Allen Oliff
Farnesyltransferase inhibitors and anti-Ras therapy.
Breast cancer research and treatment 1996;38(1):75-83.
1993: Theresa M Williams; T M Ciccarone; Suzanne C MacTough; C S Rooney; Suresh K Balani; Jon H Condra; Emilio A Emini; M E Goldman; W J Greenlee; L R Kauffman
5-chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase.
Journal of medicinal chemistry 1993;36(9):1291-4.
1993: J M Hoffman; A M Smith; C S Rooney; T E Fisher; J S Wai; C M Thomas; D L Bamberger; J L Barnes; Theresa M Williams; J H Jones
Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-[2-(Benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one and analogues.
Journal of medicinal chemistry 1993;36(8):953-66.
1993: J S Wai; Theresa M Williams; D L Bamberger; T E Fisher; J M Hoffman; R J Hudcosky; Suzanne C MacTough; C S Rooney; W S Saari; C M Thomas
Synthesis and evaluation of 2-pyridinone derivatives as specific HIV-1 reverse transcriptase inhibitors. 3. Pyridyl and phenyl analogs of 3-aminopyridin-2(1H)-one.
Journal of medicinal chemistry 1993;36(2):249-55.