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Nicholas Williamson

Research Profile

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TOP 3
Andrew J Hart; Geoffrey K Isbister; Paul O'Donnell; Nicholas A Williamson; Wayne C Hodgson
Species differences in the neuromuscular activity of post-synaptic neurotoxins from two Australian black snakes (Pseudechis porphyriacus and Pseudechis colletti).
M Iqbal Hossain; M Aizuddin Kamaruddin; Dominic C H Ng; Carli L Roulston; Nicholas A Williamson; Steve N Cheung; Percy W Y Chu; Gregory J Dusting; Donald J Fujita; Andrew F Hill; Jeffrey D Bjorge; Tung O Chan; Heung-Chin Cheng
A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity.
Lars Kjer-Nielsen; Lyudmila Kostenko; Jérôme Le Nours; Ligong Liu; Mugdha Bhati; Zhenjun Chen; Alexandra J Corbett; Nadine L Dudek; David P Fairlie; Dale I Godfrey; George N Khairallah; Malcolm J McConville; Bronwyn Meehan; Richard A J O'Hair; Onisha Patel; Anthony W Purcell; Rangsima Reantragoon; Jamie Rossjohn; Nicholas A Williamson; James McCluskey
MR1 presents microbial vitamin B metabolites to MAIT cells.

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All Publications

2013: Andrew J Hart; Geoffrey K Isbister; Paul O'Donnell; Nicholas A Williamson; Wayne C Hodgson
Species differences in the neuromuscular activity of post-synaptic neurotoxins from two Australian black snakes (Pseudechis porphyriacus and Pseudechis colletti).
Toxicology letters 2013;219(3):262-8.
2013: M Iqbal Hossain; M Aizuddin Kamaruddin; Dominic C H Ng; Carli L Roulston; Nicholas A Williamson; Steve N Cheung; Percy W Y Chu; Gregory J Dusting; Donald J Fujita; Andrew F Hill; Jeffrey D Bjorge; Tung O Chan; Heung-Chin Cheng
A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity.
The Journal of biological chemistry 2013;288(14):9696-709.
2012: Lars Kjer-Nielsen; Lyudmila Kostenko; Jérôme Le Nours; Ligong Liu; Mugdha Bhati; Zhenjun Chen; Alexandra J Corbett; Nadine L Dudek; David P Fairlie; Dale I Godfrey; George N Khairallah; Malcolm J McConville; Bronwyn Meehan; Richard A J O'Hair; Onisha Patel; Anthony W Purcell; Rangsima Reantragoon; Jamie Rossjohn; Nicholas A Williamson; James McCluskey
MR1 presents microbial vitamin B metabolites to MAIT cells.
Nature 2012;491(7426):717-23.
2012: Patricia T Illing; Lars Kjer-Nielsen; Lyudmila Kostenko; Mandvi Bharadwaj; Scott R Burrows; Zhenjun Chen; Nadine L Dudek; Stephanie Gras; John J Miles; Anthony W Purcell; Jamie Rossjohn; Julian P Vivian; Nicholas A Williamson; James McCluskey
Immune self-reactivity triggered by drug-modified HLA-peptide repertoire.
Nature 2012;486(7404):554-8.
2012: Katherine E Scull; Nicholas A Williamson; Sri H Ramarathinam; Alexandra J Corbett; Nadine L Dudek; Dhana G Gorasia; Anthony W Purcell
Secreted HLA recapitulates the immunopeptidome and allows in-depth coverage of HLA A*02:01 ligands.
Molecular immunology 2012;51(2):136-42.
2011: Helena Safavi-Hemami; William A Siero; Nicholas A Williamson; Neil D Young; Dhana G Gorasia; David Macmillan; Anthony W Purcell
Specialisation of the venom gland proteome in predatory cone snails reveals functional diversification of the conotoxin biosynthetic pathway.
Journal of proteome research 2011;10(9):3904-19.
2011: Chor Teck Tan; Nathan P Croft; Nadine L Dudek; Nicholas A Williamson; Anthony W Purcell
Direct quantitation of MHC-bound peptide epitopes by selected reaction monitoring.
Proteomics 2011;11(11):2336-40.
2011: Charles B Reilly; Sri H Ramarathinam; Nicholas A Williamson; Anthony W Purcell
Stable isotope shifted matrices enable the use of low mass ion precursor scanning for targeted metabolite identification.
Proteome science 2011;9(1):2.
2011: Nicholas A Williamson; Charles Reilly; Chor-Teck Tan; Sri-Harsha Ramarathinam; Alun Jones; Christie L Hunter; FR Rooney; Anthony W Purcell
A novel strategy for the targeted analysis of protein and peptide metabolites.
Proteomics 2011;11(2):183-92.
2010: Helena Safavi-Hemami; Neil D Young; Nicholas A Williamson; Anthony W Purcell
Proteomic interrogation of venom delivery in marine cone snails: novel insights into the role of the venom bulb.
Journal of proteome research 2010;9(11):5610-9.
2010: Helena Safavi-Hemami; Grzegorz Bulaj; Baldomero M Olivera; Nicholas A Williamson; Anthony W Purcell
Identification of Conus peptidylprolyl cis-trans isomerases (PPIases) and assessment of their role in the oxidative folding of conotoxins.
The Journal of biological chemistry 2010;285(17):12735-46.
2010: Alex Theodossis; Carole Guillonneau; Andrew Welland; Lauren K Ely; Craig S Clements; Nicholas A Williamson; Andrew Webb; Jackie A Wilce; Roger J Mulder; Michelle A Dunstone; Peter C Doherty; James McCluskey; Anthony W Purcell; Stephen J Turner; Jamie Rossjohn
Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(12):5534-9.
2010: Renu Shankar; Matthew P Johnson; Nicholas A Williamson; Fiona Cullinane; Anthony W Purcell; Eric K Moses; Shaun P Brennecke
Molecular markers of preterm labor in the choriodecidua.
Reproductive sciences (Thousand Oaks, Calif.) 2010;17(3):297-310.
2010: Khatira Anwari; Sebastian Poggio; Andrew Perry; Xenia Gatsos; Sri Harsha Ramarathinam; Nicholas A Williamson; Nicholas Noinaj; Susan Buchanan; Kipros Gabriel; Anthony W Purcell; Christine Jacobs-Wagner; Trevor Lithgow
A modular BAM complex in the outer membrane of the alpha-proteobacterium Caulobacter crescentus.
PloS one 2010;5(1):e8619.
2009: Stuart I Mannering; S H Pang; Nicholas A Williamson; Gaetano Naselli; E C Reynolds; N M O'Brien-Simpson; Anthony W Purcell; Leonard C Harrison
The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetes.
Clinical and experimental immunology 2009;156(2):226-31.
2009: Jan Petersen; Stephanie J Wurzbacher; Nicholas A Williamson; Sri H Ramarathinam; Hugh Reid; Ashish K N Nair; Anne Y Zhao; Roza Nastovska; Geordie Rudge; Jamie Rossjohn; Anthony W Purcell
Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2776-81.
2008: Diana Chessman; Lyudmila Kostenko; Tessa Lethborg; Anthony W Purcell; Nicholas A Williamson; Zhenjun Chen; Lars Kjer-Nielsen; Nicole Mifsud; Brian D Tait; Rhonda Holdsworth; Coral-Ann Almeida; David Nolan; Whitney A Macdonald; Julia K Archbold; Anthony D Kellerher; Debbie Marriott; Simon Mallal; Mandvi Bharadwaj; Jamie Rossjohn; James McCluskey
Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity.
Immunity 2008;28(6):822-32.
2007: J Steuten; Ken Winkel; T Carroll; Nicholas A Williamson; Vera Ignjatovic; K Fung; Anthony W Purcell; Bryan Fry
The molecular basis of cross-reactivity in the Australian Snake Venom Detection Kit (SVDK).
Toxicon : official journal of the International Society on Toxinology 2007;50(8):1041-52.
2007: Tamara L Etto; Lisbeth A Stewart; Thi H O Nguyen; Nicholas A Williamson; Anthony W Purcell; Anthony P Schwarer
Expression and purification of the minor histocompatibility antigen, HA-1H generated in Escherichia coli.
Protein expression and purification 2007;54(1):176-82.
2007: Fleur E Tynan; Hugh Reid; Lars Kjer-Nielsen; John J Miles; Matthew C J Wilce; Lyudmila Kostenko; Natalie A Borg; Nicholas A Williamson; Travis Beddoe; Anthony W Purcell; Scott R Burrows; James McCluskey; Jamie Rossjohn
A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule.
Nature immunology 2007;8(3):268-76.
2006: Yuh-Ping Chong; Andrew S Chan; Khai-Chew Chan; Nicholas A Williamson; Edwina C Lerner; Thomas E Smithgall; Jeffrey D Bjorge; Donald J Fujita; Anthony W Purcell; Glen M Scholz; Terrence D Mulhern; Heung-Chin Cheng
C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases.
The Journal of biological chemistry 2006;281(44):32988-99.
2006: Nicholas A Williamson; Jamie Rossjohn; Anthony W Purcell
Tumors reveal their secrets to cytotoxic T cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(40):14649-50.
2006: Lars Kjer-Nielsen; Natalie A Borg; Daniel G Pellicci; Travis Beddoe; Lyudmila Kostenko; Craig S Clements; Nicholas A Williamson; Mark J Smyth; Gurdyal S Besra; Hugh Reid; Mandvi Bharadwaj; Dale I Godfrey; Jamie Rossjohn; James McCluskey
A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.
The Journal of experimental medicine 2006;203(3):661-73.
2006: Lara Grollo; Joseph Torresi; Heidi E Drummer; Weiguang Zeng; Nicholas A Williamson; David C Jackson
Exploiting information inherent in binding sites of virus-specific antibodies: design of an HCV vaccine candidate cross-reactive with multiple genotypes.
Antiviral therapy 2006;11(8):1005-14.
2005: Fleur E Tynan; Diah Elhassen; Anthony W Purcell; Jacqueline M Burrows; Natalie A Borg; John J Miles; Nicholas A Williamson; Katherine J Green; Ross Tellam; Lars Kjer-Nielsen; James McCluskey; Jamie Rossjohn; Scott R Burrows
The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation.
The Journal of experimental medicine 2005;202(9):1249-60.
2005: Stuart I Mannering; Leonard C Harrison; Nicholas A Williamson; Jessica S Morris; Daniel J Thearle; Kent P Jensen; Thomas W H Kay; Jamie Rossjohn; Ben A Falk; Gerald Nepom; Anthony W Purcell
The insulin A-chain epitope recognized by human T cells is posttranslationally modified.
The Journal of experimental medicine 2005;202(9):1191-7.
2005: Andrew Webb; Michelle A Dunstone; Nicholas A Williamson; Jason D Price; Andrea L de Kauwe; Weisan Chen; Aaron Oakley; Patrick Perlmutter; James McCluskey; Marie-Isabel Aguilar; Jamie Rossjohn; Anthony W Purcell
T cell determinants incorporating beta-amino acid residues are protease resistant and remain immunogenic in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3810-8.
2005: Roberto Cappai; Su-Ling Leck; Deborah J Tew; Nicholas A Williamson; David P Smith; Denise Galatis; Robyn A Sharples; Cyril C Curtain; Feda E Ali; Robert A Cherny; Janetta G Culvenor; Stephen P Bottomley; Colin L Masters; Kevin J Barnham; Andrew Hill
Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(10):1377-9.
2005: Nicholas A Williamson; Anthony W Purcell
Use of proteomics to define targets of T-cell immunity.
Expert review of proteomics 2005;2(3):367-80.
2004: Agata Rekas; Christopher G Adda; J Andrew Aquilina; Kevin J Barnham; Margaret Sunde; Denise Galatis; Nicholas A Williamson; Colin L Masters; Robin F Anders; Carol V Robinson; Roberto Cappai; John A Carver
Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity.
Journal of molecular biology 2004;340(5):1167-83.
2004: Janetta G Culvenor; Nancy T Ilaya; Michael T Ryan; Louise Canterford; David E Hoke; Nicholas A Williamson; Catriona A McLean; Colin L Masters; Geneviève Evin
Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations.
European journal of biochemistry / FEBS 2004;271(2):375-85.
2003: Janelle Nunan; Nicholas A Williamson; Andrew Hill; M Fleur Sernee; Colin L Masters; David Small
Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein.
Journal of neuroscience research 2003;74(3):378-85.
2003: Kevin J Barnham; Giuseppe D Ciccotosto; Anna K Tickler; Feda E Ali; Danielle G Smith; Nicholas A Williamson; Yuen-Han Lam; Darryl Carrington; Deborah J Tew; Gulcan Kocak; Irene Volitakis; Frances Separovic; Colin J Barrow; John D Wade; Colin L Masters; Robert A Cherny; Cyril C Curtain; Ashley I Bush; Roberto Cappai
Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation.
The Journal of biological chemistry 2003;278(44):42959-65.
2003: Kevin J Barnham; William J McKinstry; Gerd Multhaup; Denise Galatis; Craig J Morton; Cyril C Curtain; Nicholas A Williamson; Anthony R White; Mark G Hinds; Raymond S Norton; Konrad Beyreuther; Colin L Masters; Michael W Parker; Roberto Cappai
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis.
The Journal of biological chemistry 2003;278(19):17401-7.
2000: T M Johnson; Nicholas A Williamson; Glen M Scholz; Anthony Jaworowski; Richard E H Wettenhall; Ashley R Dunn; Heung-Chin Cheng
Modulation of the catalytic activity of the Src family tyrosine kinase Hck by autophosphorylation at a novel site in the unique domain.
The Journal of biological chemistry 2000;275(43):33353-64.
1997: Nicholas A Williamson; J Raliegh; N A Morrice; Richard E H Wettenhall
Post-translational processing of rat ribosomal proteins. Ubiquitous methylation of Lys22 within the zinc-finger motif of RL40 (carboxy-terminal extension protein 52) and tissue-specific methylation of Lys4 in RL29.
European journal of biochemistry / FEBS 1997;246(3):786-93.