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Thomas Willnow

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Anne-Sophie Carlo-Spiewok; Camilla Gustafsen; Daniela Hartl; Joerg Heeren; Joachim Herz; Stefan Kempa; Guido Mastrobuoni; Morten S Nielsen; Anders Nykjaer; Claus M Petersen; Michael Rohe; Tilman Burgert; Thomas E Willnow
The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain.
Thomas E Willnow; Annabel Christ; Annette Hammes
Endocytic receptor-mediated control of morphogen signaling.
Stefanie Herda; Uta E Höpken; Anja A Kühl; Hans-Willi Mittrücker; Friederike Raczkowski; Tilman Breiderhoff; Bernd Dörken; Kerstin Gerlach; Gerald Willimsky; Thomas E Willnow; Armin Rehm
The sorting receptor Sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.

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2013: Anne-Sophie Carlo-Spiewok; Camilla Gustafsen; Daniela Hartl; Joerg Heeren; Joachim Herz; Stefan Kempa; Guido Mastrobuoni; Morten S Nielsen; Anders Nykjaer; Claus M Petersen; Michael Rohe; Tilman Burgert; Thomas E Willnow
The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(1):358-70.
2012: Thomas E Willnow; Annabel Christ; Annette Hammes
Endocytic receptor-mediated control of morphogen signaling.
Development (Cambridge, England) 2012;139(23):4311-9.
2012: Stefanie Herda; Uta E Höpken; Anja A Kühl; Hans-Willi Mittrücker; Friederike Raczkowski; Tilman Breiderhoff; Bernd Dörken; Kerstin Gerlach; Gerald Willimsky; Thomas E Willnow; Armin Rehm
The sorting receptor Sortilin exhibits a dual function in exocytic trafficking of interferon-γ and granzyme A in T cells.
Immunity 2012;37(5):854-66.
2012: Tilman Breiderhoff; Nina Himmerkus; Iwan C Meij; Kerim Mutig; Marchel Stuiver; Constanze Will; Thomas E Willnow; Sebastian Bachmann; Markus Bleich; Dominik Müller
Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(35):14241-6.
2012: Anders Nykjaer; Thomas E Willnow
Sortilin: a receptor to regulate neuronal viability and function.
Trends in neurosciences 2012;35(4):261-70.
2012: Safak Caglayan; Anne-Sophie Carlo-Spiewok; Norbert Hübner; Thaneas Prabakaran; Vanessa Schmidt; Anja Bauerfeind; Thomas E Willnow
Identification of Alzheimer disease risk genotype that predicts efficiency of SORL1 expression in the brain.
Archives of neurology 2012;69(3):373-9.
2012: Annabel Christ; Anna Christa; Esther Kur; Oleg Lioubinski; Thomas E Willnow; Sebastian Bachmann; Annette Hammes
LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.
Developmental cell 2012;22(2):268-78.
2011: Esther Kur; Anna Christa; Kerry N Veth; Chandresh R Gajera; Miguel A Andrade-Navarro; Jingjing Zhang; Jason R Willer; Ronald G Gregg; Salim Abdelilah-Seyfried; Sebastian Bachmann; Brian A Link; Annette Hammes; Thomas E Willnow
Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development.
Developmental dynamics : an official publication of the American Association of Anatomists 2011;240(6):1567-77.
2011: Thomas E Willnow; Mads Kjølby; Anders Nykjaer
Sortilins: new players in lipoprotein metabolism.
Current opinion in lipidology 2011;22(2):79-85.
2011: Marchel Stuiver; Sergio Lainez; Constanze Will; Sara Terryn; Dorothee Günzel; Huguette Debaix; Kerstin Sommer; Kathrin Kopplin; Julia Thumfart; Nicole B Kampik; Uwe Querfeld; Thomas E Willnow; Vladimír Němec; Carsten A Wagner; Joost G Hoenderop; Olivier Devuyst; Nine V A M Knoers; René J Bindels; Iwan C Meij; Dominik Müller
CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia.
American journal of human genetics 2011;88(3):333-43.
2011: Christian Vaegter; Pernille Jansen; Anja W Fjorback; Simon Glerup; Sune Skeldal; Mads Kjolby; Mette Richner; Bettina Erdmann; Jens R Nyengaard; Lino Tessarollo; Gary R Lewin; Thomas E Willnow; Moses V Chao; Anders Nykjaer
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
Nature neuroscience 2011;14(1):54-61.
2011: M V Sorensen; H A Praetorius; A Nykjaer; Thomas E Willnow; Jens Leipziger
Impaired aldosterone responsiveness in corticosteroid binding globulin deficient mice.
Acta physiologica (Oxford, England) 2011;201(1):169-77.
2010: Sabine Amsellem; Jakub Gburek; Ghislaine Hamard; Rikke Nielsen; Thomas E Willnow; Olivier Devuyst; Ebba Nexo; Pierre J Verroust; Erik I Christensen; Renata Kozyraki
Cubilin is essential for albumin reabsorption in the renal proximal tubule.
Journal of the American Society of Nephrology : JASN 2010;21(11):1859-67.
2010: Mads Kjolby; Olav M Andersen; Tilman Breiderhoff; Anja W Fjorback; Karen Marie Pedersen; Peder Madsen; Pernille Jansen; Joerg Heeren; Thomas E Willnow; Anders Nykjaer
Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.
Cell metabolism 2010;12(3):213-23.
2010: Annabel Christ; Sara Terryn; Vanessa Schmidt; Erik I Christensen; Matthew R Huska; Miguel A Andrade-Navarro; Norbert Hübner; Olivier Devuyst; Annette Hammes; Thomas E Willnow
The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo.
Kidney international 2010;78(5):473-7.
2010: Chandresh Gajera; Helena Emich; Oleg Lioubinski; Annabel Christ; Ruth Beckervordersandforth-Bonk; Kazuaki Yoshikawa; Sebastian Bachmann; Erik Ilsø Christensen; Magdalena Götz; Gerd Kempermann; Andrew S Peterson; Thomas E Willnow; Annette Hammes
LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche.
Journal of cell science 2010;123(Pt 11):1922-30.
2010: Juliane Reiche; Franziska Theilig; Fatema H Rafiqi; Anne-Sophie Carlo-Spiewok; Daniel Militz; Kerim Mutig; Mihail Todiras; Erik Ilsø Christensen; David H Ellison; Michael Bader; Anders Nykjaer; Sebastian Bachmann; Dario Alessi; Thomas E Willnow
SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2.
Molecular and cellular biology 2010;30(12):3027-37.
2010: Constanze Will; Thomas E Willnow; Markus Bleich; Tilman Breiderhoff; Dorothee Günzel; Kathrin Kopplin; Iwan C Meij; Uwe Querfeld; Qixian Shan; Kerstin Sommer; Marchel Stuiver; Julia Thumfart; Dominik Müller
Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting.
American journal of physiology. Renal physiology 2010;298(5):F1152-61.
2010: Olga Serup Andersen; Prisca Boisguerin; Simon Glerup; Sune Skeldal; Rudolf Volkmer; Thomas E Willnow; Anders Nykjaer; Olav M Andersen
Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding.
The Journal of biological chemistry 2010;285(16):12210-22.
2010: Thomas E Willnow; Anders Nykjaer
Cellular uptake of steroid carrier proteins--mechanisms and implications.
Molecular and cellular endocrinology 2010;316(1):93-102.
2010: Jingjing Zhang; Jörg Piontek; Hartwig Wolburg; Christian Piehl; Martin Liss; Cécile Otten; Annabel Christ; Thomas E Willnow; Ingolf E Blasig; Salim Abdelilah-Seyfried
Establishment of a neuroepithelial barrier by Claudin5a is essential for zebrafish brain ventricular lumen expansion.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(4):1425-30.
2010: Thomas E Willnow; Anne-Sophie Carlo-Spiewok; Michael Rohe; Vanessa Schmidt
SORLA/SORL1, a neuronal sorting receptor implicated in Alzheimer's disease.
Reviews in the neurosciences 2010;21(4):315-29.
2009: Michael Rohe; Michael Synowitz; Rainer Glass; Steven M Paul; Anders Nykjaer; Thomas E Willnow
Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(49):15472-8.
2008: Thomas E Willnow; Claus M Petersen; Anders Nykjaer
VPS10P-domain receptors - regulators of neuronal viability and function.
Nature reviews. Neuroscience 2008;9(12):899-909.
2008: Sara Dodson; Olav M Andersen; Vinit Karmali; Jason J Fritz; Dongmei Cheng; Junmin Peng; Allan Levey; Thomas E Willnow; James J Lah
Loss of LR11/SORLA enhances early pathology in a mouse model of amyloidosis: evidence for a proximal role in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(48):12877-86.
2008: Yaeko Motoyoshi; Taiji Matsusaka; Akihiko Saito; Ira Pastan; Thomas E Willnow; Shuki Mizutani; Iekuni Ichikawa
Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria.
Kidney international 2008;74(10):1262-9.
2008: Michael Rohe; Anne-Sophie Carlo-Spiewok; Henning Breyhan; Anje Sporbert; Daniel Militz; Vanessa Schmidt; Christian Wozny; Anja Harmeier; Bettina Erdmann; Kelly R Bales; Susanne Wolf; Gerd Kempermann; Steven M Paul; Dietmar Schmitz; Thomas A Bayer; Thomas E Willnow; Olav M Andersen
Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis.
The Journal of biological chemistry 2008;283(21):14826-34.
2007: Vanessa Schmidt; Anje Sporbert; Michael Rohe; Tatiana A Reimer; Armin Rehm; Olav M Andersen; Thomas E Willnow
SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1.
The Journal of biological chemistry 2007;282(45):32956-64.
2007: Pernille Jansen; Klaus M Giehl; Jens R Nyengaard; Kenneth Teng; Oleg Lioubinski; Susanne S Sjoegaard; Tilman Breiderhoff; Michael Gotthardt; Fuyu Lin; Andreas Eilers; Claus M Petersen; Gary R Lewin; Barbara L Hempstead; Thomas E Willnow; Anders Nykjaer
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.
Nature neuroscience 2007;10(11):1449-57.
2007: Thomas E Willnow; Annette Hammes; Suzanne Eaton
Lipoproteins and their receptors in embryonic development: more than cholesterol clearance.
Development (Cambridge, England) 2007;134(18):3239-49.
2007: Franziska Theilig; Wilhelm Kriz; Timo Jerichow; Petra Schrade; Brunhilde Hähnel; Thomas E Willnow; Michel Le Hir; Sebastian Bachmann
Abrogation of protein uptake through megalin-deficient proximal tubules does not safeguard against tubulointerstitial injury.
Journal of the American Society of Nephrology : JASN 2007;18(6):1824-34.
2007: Rikke Nielsen; Pierre J Courtoy; Christian Jacobsen; Geneviève Dom; Wânia Rezende Lima; Michel Jadot; Thomas E Willnow; Olivier Devuyst; Erik I Christensen
Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(13):5407-12.
2006: Olav M Andersen; Thomas E Willnow
Lipoprotein receptors in Alzheimer's disease.
Trends in neurosciences 2006;29(12):687-94.
2006: Helle Heibroch Petersen; Thomas K Andreassen; Tilman Breiderhoff; Jan Hinrich Bräsen; Herbert Schulz; Volkmar Gross; Hermann-Josef Gröne; Anders Nykjaer; Thomas E Willnow
Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin.
Molecular and cellular biology 2006;26(19):7236-45.
2006: Thomas E Willnow; Olav M Andersen
Pin-pointing APP processing.
Molecular interventions 2006;6(3):137-9.
2006: Uwe Anzenberger; Nana Bit-Avragim; Stefan Rohr; Franziska Rudolph; Bastian Dehmel; Thomas E Willnow; Salim Abdelilah-Seyfried
Elucidation of megalin/LRP2-dependent endocytic transport processes in the larval zebrafish pronephros.
Journal of cell science 2006;119(Pt 10):2127-37.
2006: Stefan Donath; Peifeng Li; Christian Willenbockel; Nidal al-Saadi; Volkmar Gross; Thomas E Willnow; Michael Bader; Ulrich Martin; Johann Bauersachs; Kai C Wollert; Rainer Dietz; Rüdiger von Harsdorf
Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress.
Circulation 2006;113(9):1203-12.
2006: Olav M Andersen; Vanessa Schmidt; Robert Spoelgen; Jørgen Gliemann; Joachim Behlke; Denise Galatis; William J McKinstry; Michael W Parker; Colin L Masters; Bradley T Hyman; Roberto Cappai; Thomas E Willnow
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.
Biochemistry 2006;45(8):2618-28.
2006: Robert Spoelgen; Christine A F Von Arnim; Anne V Thomas; Ithan D Peltan; Mirjam Koker; Amy Deng; Michael C Irizarry; Olav M Andersen; Thomas E Willnow; Bradley T Hyman
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(2):418-28.
2005: Jens Raila; Thomas E Willnow; Florian Schweigert
Megalin-mediated reuptake of retinol in the kidneys of mice is essential for vitamin A homeostasis.
The Journal of nutrition 2005;135(11):2512-6.
2005: Marion De Jong; Raffaella Barone; Eric P Krenning; Bert Bernard; Marleen Melis; Theo Visser; Michael Gekle; Thomas E Willnow; stephan walrand; François Jamar; Stanislas Pauwels
Megalin is essential for renal proximal tubule reabsorption of (111)In-DTPA-octreotide.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(10):1696-700.
2005: Olav M Andersen; Juliane Reiche; Vanessa Schmidt; Michael Gotthardt; Robert Spoelgen; Joachim Behlke; Christine A F Von Arnim; Tilman Breiderhoff; Pernille Jansen; Xin Wu; Kelly R Bales; Roberto Cappai; Colin L Masters; Jørgen Gliemann; Elliott J Mufson; Bradley T Hyman; Steven M Paul; Anders Nykjaer; Thomas E Willnow
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13461-6.
2005: Annette Hammes; Thomas K Andreassen; Robert Spoelgen; Jens Raila; Norbert Hubner; Herbert Schulz; Jochen Metzger; Florian Schweigert; Peter B Luppa; Anders Nykjaer; Thomas E Willnow
Role of endocytosis in cellular uptake of sex steroids.
Cell 2005;122(5):751-62.
2005: J Nagai; Erik I Christensen; S M Morris; Thomas E Willnow; J A Cooper; Rikke Nielsen
Mutually dependent localization of megalin and Dab2 in the renal proximal tubule.
American journal of physiology. Renal physiology 2005;289(3):F569-76.
2005: Anders Nykjaer; Thomas E Willnow; Claus M Petersen
p75NTR--live or let die.
Current opinion in neurobiology 2005;15(1):49-57.
2005: Robert Spoelgen; Annette Hammes; Uwe Anzenberger; Dietmar Zechner; Olav M Andersen; Boris Jerchow; Thomas E Willnow
LRP2/megalin is required for patterning of the ventral telencephalon.
Development (Cambridge, England) 2005;132(2):405-14.
2004: Helle Heibroch Petersen; Jan Hilpert; Christian Jacobsen; Annick Lauwers; Anton J M Roebroek; Thomas E Willnow
Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development.
FEBS letters 2004;565(1-3):23-7.
2004: Sebastian Bachmann; Uwe Schlichting; Beate Geist; Kerim Mutig; Thomas Petsch; Desa Bacic; Carsten A Wagner; Brigitte Kaissling; Jürg Biber; Heini Murer; Thomas E Willnow
Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa).
Journal of the American Society of Nephrology : JASN 2004;15(4):892-900.
2004: Anders Nykjaer; Ramee Lee; Kenneth Teng; Pernille Jansen; Peder Madsen; Morten S Nielsen; Christian Jacobsen; Marco Kliemannel; Elisabeth Schwarz; Thomas E Willnow; Barbara L Hempstead; Claus M Petersen
Sortilin is essential for proNGF-induced neuronal cell death.
Nature 2004;427(6977):843-8.
2004: Guenter Cichon; Thomas E Willnow; Susanne Herwig; Wolfgang Uckert; Peter Löser; Hartmut H-J Schmidt; Tahar Benhidjeb; Peter M Schlag; Frank Schnieders; Dagmara Niedzielska; Joerg Heeren
Non-physiological overexpression of the low density lipoprotein receptor (LDLr) gene in the liver induces pathological intracellular lipid and cholesterol storage.
The journal of gene medicine 2004;6(2):166-75.
2003: Simonetta Lisi; Aldo Pinchera; Robert T McCluskey; Thomas E Willnow; Samuel Refetoff; Claudio Marcocci; Paolo Vitti; Francesca Menconi; Lucia Grasso; Fabiana Luchetti; A Bernard Collins; Michele Marino
Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone release.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):14858-63.
2003: Jakub Gburek; Henrik Birn; Pierre J Verroust; Bogusława Goj; Christian Jacobsen; Søren K Moestrup; Thomas E Willnow; Erik I Christensen
Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin.
American journal of physiology. Renal physiology 2003;285(3):F451-8.
2003: Olav M Andersen; David Benhayon; Tom Curran; Thomas E Willnow
Differential binding of ligands to the apolipoprotein E receptor 2.
Biochemistry 2003;42(31):9355-64.
2003: Olav M Andersen; Ching-Hei Yeung; Henrik Vorum; Maren Wellner; Thomas K Andreassen; Bettina Erdmann; Eva-Christina Mueller; Joachim Herz; Albrecht Otto; Trevor G Cooper; Thomas E Willnow
Essential role of the apolipoprotein E receptor-2 in sperm development.
The Journal of biological chemistry 2003;278(26):23989-95.
2003: Helle Heibroch Petersen; Jan Hilpert; Daniel Militz; Valerie Zandler; Christian Jacobsen; Anton J M Roebroek; Thomas E Willnow
Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule.
Journal of cell science 2003;116(Pt 3):453-61.
2003: Jörg R Leheste; Flemming Melsen; Maren Wellner; Pernille Jansen; Uwe Schlichting; Ingrid Renner-Müller; Troels T Andreassen; Eckehard Wolf; Sebastian Bachmann; Anders Nykjaer; Thomas E Willnow
Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(2):247-9.
2003: Dominik Müller; Anders Nykjaer; Thomas E Willnow
From holoprosencephaly to osteopathology: role of multifunctional endocytic receptors in absorptive epithelia.
Annals of medicine 2003;35(5):290-9.
2002: Jan Hilpert; Lise Wogensen; Thomas Thykjaer; Maren Wellner; Uwe Schlichting; Torben F Orntoft; Sebastian Bachmann; Anders Nykjaer; Thomas E Willnow
Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism.
Kidney international 2002;62(5):1672-81.
2002: Mathias Knecht; Ines Pagel; Thomas Langenickel; Sebastian Philipp; Michaela Scheuermann-Freestone; Thomas E Willnow; Dennis Bruemmer; Kristof Graf; Rainer Dietz; Roland Willenbrock
Increased expression of renal neutral endopeptidase in severe heart failure.
Life sciences 2002;71(23):2701-12.
2002: Anders Nykjaer; Thomas E Willnow
The low-density lipoprotein receptor gene family: a cellular Swiss army knife?
Trends in cell biology 2002;12(6):273-80.
2002: Thomas E Willnow; Anders Nykjaer
Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D3.
Current opinion in lipidology 2002;13(3):255-60.
2002: Henrik Birn; Thomas E Willnow; Rikke Nielsen; Anthony G W Norden; Christian Bönsch; Søren K Moestrup; Ebba Nexø; Erik I Christensen
Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12).
American journal of physiology. Renal physiology 2002;282(3):F408-16.
2002: Jakub Gburek; Pierre J Verroust; Thomas E Willnow; John C Fyfe; Wojciech Nowacki; Christian Jacobsen; Søren K Moestrup; Erik I Christensen
Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin.
Journal of the American Society of Nephrology : JASN 2002;13(2):423-30.
2002: Christian Schmitz; Jan Hilpert; Christian Jacobsen; Christian Boensch; Erik I Christensen; Friedrich C Luft; Thomas E Willnow
Megalin deficiency offers protection from renal aminoglycoside accumulation.
The Journal of biological chemistry 2002;277(1):618-22.
2001: Jan Hilpert; Henrik Vorum; R Burmeister; Robert Spoelgen; I Grishkovskaya; R Misselwitz; Anders Nykjaer; Thomas E Willnow
Efficient eukaryotic expression system for authentic human sex hormone-binding globulin.
The Biochemical journal 2001;360(Pt 3):609-15.
2001: Anders Nykjaer; John C Fyfe; Renata Kozyraki; Jörg R Leheste; Christian Jacobsen; Morten S Nielsen; Pierre J Verroust; Maria Aminoff; Albert de La Chapelle; Søren K Moestrup; R Ray; Jørgen Gliemann; Thomas E Willnow; Erik I Christensen
Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3).
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13895-900.
2001: Renata Kozyraki; John C Fyfe; Pierre J Verroust; Christian Jacobsen; A Dautry-Varsat; Jakub Gburek; Thomas E Willnow; Erik I Christensen; Søren K Moestrup
Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12491-6.
2001: R Burmeister; Inger-Margrethe Boe; Anders Nykjaer; Christian Jacobsen; S K Moestrup; Pierre J Verroust; Erik I Christensen; Johan Lund; Thomas E Willnow
A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney.
The Journal of biological chemistry 2001;276(16):13295-301.
2001: D Müller; T Ankermann; U Stephani; M Kirschstein; T Szelestei; Friedrich C Luft; Thomas E Willnow
Holoprosencephaly and low molecular weight proteinuria: the human homologue of murine megalin deficiency.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2001;37(3):624-8.
2000: Mónica Mendes Sousa; Anthony G W Norden; C Jacobsen; Thomas E Willnow; Erik I Christensen; Rajesh V Thakker; Pierre J Verroust; Søren K Moestrup; Maria João Saraiva
Evidence for the role of megalin in renal uptake of transthyretin.
The Journal of biological chemistry 2000;275(49):38176-81.
2000: C Schmitz; Michael Gotthardt; S Hinderlich; Jörg R Leheste; V Gross; Henrik Vorum; Erik I Christensen; Friedrich C Luft; S Takahashi; Thomas E Willnow
Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor.
The Journal of biological chemistry 2000;275(20):15357-62.
2000: Henrik Birn; John C Fyfe; Christian Jacobsen; F Mounier; Pierre J Verroust; H Orskov; Thomas E Willnow; Søren K Moestrup; Erik I Christensen
Cubilin is an albumin binding protein important for renal tubular albumin reabsorption.
The Journal of clinical investigation 2000;105(10):1353-61.
2000: Joachim Herz; Michael Gotthardt; Thomas E Willnow
Cellular signalling by lipoprotein receptors.
Current opinion in lipidology 2000;11(2):161-6.
1999: Thomas E Willnow; Anders Nykjaer; Joachim Herz
Lipoprotein receptors: new roles for ancient proteins.
Nature cell biology 1999;1(6):E157-62.
1999: Jörg R Leheste; B Rolinski; Henrik Vorum; Jan Hilpert; Anders Nykjaer; Christian Jacobsen; P Aucouturier; JO Moskaug; A Otto; Erik I Christensen; Thomas E Willnow
Megalin knockout mice as an animal model of low molecular weight proteinuria.
The American journal of pathology 1999;155(4):1361-70.
1999: Erik I Christensen; Thomas E Willnow
Essential role of megalin in renal proximal tubule for vitamin homeostasis.
Journal of the American Society of Nephrology : JASN 1999;10(10):2224-36.
1999: Erik I Christensen; JO Moskaug; Henrik Vorum; Christian Jacobsen; Thomas Gundersen; Anders Nykjaer; Rune Blomhoff; Thomas E Willnow; Søren K Moestrup
Evidence for an essential role of megalin in transepithelial transport of retinol.
Journal of the American Society of Nephrology : JASN 1999;10(4):685-95.
1999: Andreas Niemeier; Thomas E Willnow; H Dieplinger; C Jacobsen; N Meyer; J Hilpert; Ulrike Beisiegel
Identification of megalin/gp330 as a receptor for lipoprotein(a) in vitro.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(3):552-61.
1999: Jan Hilpert; Anders Nykjaer; Christian Jacobsen; Gerd Wallukat; R Nielsen; S K Moestrup; Hermann Haller; Friedrich C Luft; Erik I Christensen; Thomas E Willnow
Megalin antagonizes activation of the parathyroid hormone receptor.
The Journal of biological chemistry 1999;274(9):5620-5.
1999: Anders Nykjaer; D Dragun; D Walther; Henrik Vorum; Christian Jacobsen; Joachim Herz; F Melsen; Erik I Christensen; Thomas E Willnow
An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3.
Cell 1999;96(4):507-15.
1998: Søren K Moestrup; I Schousboe; Christian Jacobsen; Jörg R Leheste; Erik I Christensen; Thomas E Willnow
beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin.
The Journal of clinical investigation 1998;102(5):902-9.
1998: Thomas E Willnow
Receptor-associated protein (RAP): a specialized chaperone for endocytic receptors.
Biological chemistry 1998;379(8-9):1025-31.
1997: T Reblin; Andreas Niemeier; N Meyer; Thomas E Willnow; F Kronenberg; H Dieplinger; Heiner Greten; Ulrike Beisiegel
Cellular uptake of lipoprotein[a] by mouse embryonic fibroblasts via the LDL receptor and the LDL receptor-related protein.
Journal of lipid research 1997;38(10):2103-10.
1997: Thomas E Willnow
Mechanisms of hepatic chylomicron remnant clearance.
Diabetic medicine : a journal of the British Diabetic Association 1997;14 Suppl 3():S75-80.
1997: Joachim Herz; Thomas E Willnow; R V Farese
Cholesterol, hedgehog and embryogenesis.
Nature genetics 1997;15(2):123-4.
1996: A Rohlmann; Michael Gotthardt; Thomas E Willnow; Robert E Hammer; Joachim Herz
Sustained somatic gene inactivation by viral transfer of Cre recombinase.
Nature biotechnology 1996;14(11):1562-5.
1996: Photini Sinnis; Thomas E Willnow; Marcelo RS Briones; Joachim Herz; Victor Nussenzweig
Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes.
The Journal of experimental medicine 1996;184(3):945-54.
1996: J R Braun; Thomas E Willnow; S Ishibashi; G Ashwell; Joachim Herz
The major subunit of the asialoglycoprotein receptor is expressed on the hepatocellular surface in mice lacking the minor receptor subunit.
The Journal of biological chemistry 1996;271(35):21160-6.
1996: Thomas E Willnow; Jan Hilpert; Scott A Armstrong; A Rohlmann; Robert E Hammer; DK Burns; Joachim Herz
Defective forebrain development in mice lacking gp330/megalin.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8460-4.
1996: Thomas E Willnow; A Rohlmann; J Horton; H Otani; J R Braun; Robert E Hammer; Joachim Herz
RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors.
The EMBO journal 1996;15(11):2632-9.
1996: E Sehayek; X X Wang; Israel Vlodavsky; R Avner; Hana Levkovitz; Thomas Olivecrona; G Olivecrona; Thomas E Willnow; Joachim Herz; S Eisenberg
Heparan sulfate-dependent and low density lipoprotein receptor-related protein-dependent catabolic pathways for lipoprotein lipase in mouse embryonic fibroblasts.
Israel journal of medical sciences 1996;32(6):449-54.
1996: Thomas E Willnow; J M Moehring; N M Inocencio; T J Moehring; Joachim Herz
The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.
The Biochemical journal 1996;313 ( Pt 1)():71-6.
1995: Joachim Herz; Thomas E Willnow
Gene transfer and disruption strategies to elucidate hepatic lipoprotein receptor functions.
Atherosclerosis 1995;118 Suppl():S37-41.
1995: Thomas E Willnow; Scott A Armstrong; Robert E Hammer; Joachim Herz
Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4537-41.
1995: Thomas E Willnow; Joachim Herz
Animal models for disorders of hepatic lipoprotein metabolism.
Journal of molecular medicine (Berlin, Germany) 1995;73(5):213-20.
1995: Joachim Herz; Thomas E Willnow
Lipoprotein and receptor interactions in vivo.
Current opinion in lipidology 1995;6(2):97-103.
1995: Wolfgang Poller; Thomas E Willnow; Jan Hilpert; Joachim Herz
Differential recognition of alpha 1-antitrypsin-elastase and alpha 1-antichymotrypsin-cathepsin G complexes by the low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1995;270(6):2841-5.
1994: Joachim Herz; Thomas E Willnow
Functions of the LDL receptor gene family.
Annals of the New York Academy of Sciences 1994;737():14-9.
1994: K Orth; Thomas E Willnow; Joachim Herz; Mary-Jane Gething; J Sambrook
Low density lipoprotein receptor-related protein is necessary for the internalization of both tissue-type plasminogen activator-inhibitor complexes and free tissue-type plasminogen activator.
The Journal of biological chemistry 1994;269(33):21117-22.
1994: Thomas E Willnow; Z Sheng; S Ishibashi; Joachim Herz
Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist.
Science (New York, N.Y.) 1994;264(5164):1471-4.
1994: Thomas E Willnow; K Orth; Joachim Herz
Molecular dissection of ligand binding sites on the low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1994;269(22):15827-32.
1994: Thomas E Willnow; Joachim Herz
Genetic deficiency in low density lipoprotein receptor-related protein confers cellular resistance to Pseudomonas exotoxin A. Evidence that this protein is required for uptake and degradation of multiple ligands.
Journal of cell science 1994;107 ( Pt 3)():719-26.
1994: Thomas E Willnow; Joachim Herz
Homologous recombination for gene replacement in mouse cell lines.
Methods in cell biology 1994;43 Pt A():305-34.
1992: Thomas E Willnow; Joseph L Goldstein; K Orth; Michael S Brown; Joachim Herz
Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.
The Journal of biological chemistry 1992;267(36):26172-80.