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Timothy Willson

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Richard J Whitby; Jozef Stec; Raymond D Blind; Sally Dixon; Lisa M Leesnitzer; Lisa A Orband-Miller; Shawn P Williams; Timothy M Willson; Robert Xu; William J Zuercher; Fang Cai; Holly A Ingraham
Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2).
Daniel Grant; Lei Yin; Jon L Collins; Derek J Parks; Lisa A Orband-Miller; G Bruce Wisely; Shree Joshi; Mitchell Lazar; Timothy M Willson; William J Zuercher
GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
William J Zuercher; Richard G Buckholz; Nino Campobasso; Jon L Collins; Cristin M Galardi; Robert T Gampe; Stephen M Hyatt; Susan L Merrihew; John T Moore; Jeffrey A Oplinger; Paul R Reid; Paul K Spearing; Thomas B Stanley; Eugene L Stewart; Timothy M Willson
Discovery of tertiary sulfonamides as potent liver X receptor antagonists.

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All Publications

2011: Richard J Whitby; Jozef Stec; Raymond D Blind; Sally Dixon; Lisa M Leesnitzer; Lisa A Orband-Miller; Shawn P Williams; Timothy M Willson; Robert Xu; William J Zuercher; Fang Cai; Holly A Ingraham
Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2).
Journal of medicinal chemistry 2011;54(7):2266-81.
2010: Daniel Grant; Lei Yin; Jon L Collins; Derek J Parks; Lisa A Orband-Miller; G Bruce Wisely; Shree Joshi; Mitchell Lazar; Timothy M Willson; William J Zuercher
GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.
ACS chemical biology 2010;5(10):925-32.
2010: William J Zuercher; Richard G Buckholz; Nino Campobasso; Jon L Collins; Cristin M Galardi; Robert T Gampe; Stephen M Hyatt; Susan L Merrihew; John T Moore; Jeffrey A Oplinger; Paul R Reid; Paul K Spearing; Thomas B Stanley; Eugene L Stewart; Timothy M Willson
Discovery of tertiary sulfonamides as potent liver X receptor antagonists.
Journal of medicinal chemistry 2010;53(8):3412-6.
2010: Barry G Shearer; Robert W Wiethe; Adam Ashe; Andrew N Billin; James M Way; Thomas B Stanley; Craig D Wagner; Robert X Xu; Lisa M Leesnitzer; Raymond V Merrihew; Todd W Shearer; Michael R Jeune; John C Ulrich; Timothy M Willson
Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.
Journal of medicinal chemistry 2010;53(4):1857-61.
2009: John D Norris; James David Joseph; Andrea Barreto Sherk; Dalia Juzumiene; Philip Stewart Turnbull; Stephen William Rafferty; Huaxia Cui; Erin Anderson; Daju Fan; Delita Arnelle Dye; Xiang Deng; Dmitri Kazmin; Ching-Yi Chang; Timothy M Willson; Donald P McDonnell
Differential presentation of protein interaction surfaces on the androgen receptor defines the pharmacological actions of bound ligands.
Chemistry & biology 2009;16(4):452-60.
2008: Esther Y Chao; Justin A Caravella; Mike A Watson; Nino Campobasso; Serena Ghisletti; Andrew N Billin; Cristin Galardi; Ping Wang; Bryan A Laffitte; Marie A Iannone; Bryan Goodwin; Jason A Nichols; Derek J Parks; Eugene Stewart; Robert W Wiethe; Shawn P Williams; Angela Smallwood; Kenneth H Pearce; Christopher K Glass; Timothy M Willson; William J Zuercher; Jon L Collins
Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.
Journal of medicinal chemistry 2008;51(18):5758-65.
2008: Barry G Shearer; Hari S Patel; Andrew N Billin; James M Way; Deborah Winegar; Millard H Lambert; Robert X Xu; Lisa M Leesnitzer; Raymond V Merrihew; Stephane Huet; Timothy M Willson
Discovery of a novel class of PPARdelta partial agonists.
Bioorganic & medicinal chemistry letters 2008;18(18):5018-22.
2008: Hongwei Wang; Hao Li; Linda B Moore; Michael D L Johnson; Jodi M Maglich; Bryan Goodwin; Olivia R R Ittoop; Bruce Wisely; Katrina Creech; Derek J Parks; Jon L Collins; Timothy M Willson; Ganjam V Kalpana; Madhukumar Venkatesh; Wen Xie; Sool Y Cho; John Roboz; Matthew Redinbo; John T Moore; venkatesh madhukumar
The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor.
Molecular endocrinology (Baltimore, Md.) 2008;22(4):838-57.
2008: Barry G Shearer; David J Steger; James M Way; Thomas B Stanley; David C Lobe; Didier A Grillot; Marie A Iannone; Mitchell Lazar; Timothy M Willson; Andrew N Billin
Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist.
Molecular endocrinology (Baltimore, Md.) 2008;22(2):523-9.
2008: Elizabeth E Girroir; Holly E Hollingshead; Andrew N Billin; Timothy M Willson; Gavin P. Robertson; Arun K Sharma; Shantu Amin; Frank J Gonzalez; Jeffrey M Peters
Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines.
Toxicology 2008;243(1-2):236-43.
2008: Holly E Hollingshead; Michael G Borland; Andrew N Billin; Timothy M Willson; Frank J Gonzalez; Jeffrey M Peters
Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms.
Carcinogenesis 2008;29(1):169-76.
2007: Stephen M Hyatt; Elizabeth L Lockamy; Rebecca A Stein; Donald P McDonnell; Aaron B Miller; Lisa A Orband-Miller; Timothy M Willson; William J Zuercher
On the intractability of estrogen-related receptor alpha as a target for activation by small molecules.
Journal of medicinal chemistry 2007;50(26):6722-4.
2007: Holly E Hollingshead; Renee L Killins; Michael G Borland; Elizabeth E Girroir; Andrew N Billin; Timothy M Willson; Arun K Sharma; Shantu Amin; Frank J Gonzalez; Jeffrey M Peters
Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines.
Carcinogenesis 2007;28(12):2641-9.
2007: Holly E Hollingshead; Keiichirou Morimura; Masahiro Adachi; Mary J. Kennett; Andrew N Billin; Timothy M Willson; Frank J Gonzalez; Jeffrey M Peters
PPARbeta/delta protects against experimental colitis through a ligand-independent mechanism.
Digestive diseases and sciences 2007;52(11):2912-9.
2007: Ryan P Trump; Jeffery Cobb; Barry G Shearer; Millard H Lambert; Robert T Nolte; Timothy M Willson; Richard G Buckholz; Sumin M Zhao; Lisa M Leesnitzer; Marie A Iannone; Kenneth H Pearce; Andrew N Billin; William J Hoekstra
Co-crystal structure guided array synthesis of PPARgamma inverse agonists.
Bioorganic & medicinal chemistry letters 2007;17(14):3916-20.
2007: Andrew D Burdick; Moses T Bility; Elizabeth E Girroir; Andrew N Billin; Timothy M Willson; Frank J Gonzalez; Jeffrey M Peters
Ligand activation of peroxisome proliferator-activated receptor-beta/delta(PPARbeta/delta) inhibits cell growth of human N/TERT-1 keratinocytes.
Cellular signalling 2007;19(6):1163-71.
2007: Yu Xue; Esther Chao; William J Zuercher; Timothy M Willson; Jon L Collins; Matthew R Redinbo
Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism.
Bioorganic & medicinal chemistry 2007;15(5):2156-66.
2007: Dennis L Sprecher; Christine Massien; Greg Pearce; Andrew N Billin; Itay Perlstein; Timothy M Willson; David G Hassall; nicolas ancellin; Scott D Patterson; David C Lobe; Tony G Johnson
Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(2):359-65.
2007: Serena Ghisletti; Wendy Huang; Sumito Ogawa; Gabriel Pascual; Mu-En Lin; Timothy M Willson; Michael G Rosenfeld; Christopher K Glass
Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma.
Molecular cell 2007;25(1):57-70.
2007: Ryan P Trump; Jean-Baptiste E Blanc; Eugene L Stewart; Peter J Brown; Matilde Caivano; David W Gray; William J Hoekstra; Timothy M Willson; Bajin Han; Philip Turnbull
Design and synthesis of an array of selective androgen receptor modulators.
Journal of combinatorial chemistry 2007;9(1):107-14.
2006: Liping Wang; William J Zuercher; Thomas G Consler; Millard H Lambert; Aaron B Miller; Lisa A Orband-Miller; David D McKee; Timothy M Willson; Robert T Nolte
X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.
The Journal of biological chemistry 2006;281(49):37773-81.
2006: Richard J Whitby; Sally Dixon; Patrick R Maloney; Philippe Delerive; Bryan Goodwin; Derek J Parks; Timothy M Willson
Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1.
Journal of medicinal chemistry 2006;49(23):6652-5.
2006: Holly E Marin; Marjorie A Peraza; Andrew N Billin; Timothy M Willson; Jerrold M Ward; Mary J. Kennett; Frank J Gonzalez; Jeffrey M Peters
Ligand activation of peroxisome proliferator-activated receptor beta inhibits colon carcinogenesis.
Cancer research 2006;66(8):4394-401.
2006: Esther Y H Chao; Jon L Collins; Stéphanie Gaillard; Aaron B Miller; Liping Wang; Lisa A Orband-Miller; Robert T Nolte; Donald P McDonnell; Timothy M Willson; William J Zuercher
Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma.
Bioorganic & medicinal chemistry letters 2006;16(4):821-4.
2006: Yanqiao Zhang; Florence Ying Lee; Gabriel Barrera; Hans Lee; Charisse Vales; Frank J Gonzalez; Timothy M Willson; Peter A Edwards
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(4):1006-11.
2006: Dae Joon Kim; Moses T Bility; Andrew N Billin; Timothy M Willson; Frank J Gonzalez; Jeffrey M Peters
PPARbeta/delta selectively induces differentiation and inhibits cell proliferation.
Cell death and differentiation 2006;13(1):53-60.
2005: Gabriel Pascual; Amy L Fong; Sumito Ogawa; Amir Gamliel; Andrew C Li; Valentina Perissi; David W Rose; Timothy M Willson; Michael G Rosenfeld; Christopher K Glass
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.
Nature 2005;437(7059):759-63.
2005: Randy K Bledsoe; Kevin P Madauss; Jason A Holt; Christopher J Apolito; Millard H Lambert; Kenneth H Pearce; Thomas B Stanley; Eugene L Stewart; Ryan P Trump; Timothy M Willson; Shawn P Williams
A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor.
The Journal of biological chemistry 2005;280(35):31283-93.
2005: Michael C Jaye; John A Krawiec; Nino Campobasso; Angela Smallwood; Chunyan Qiu; Quinn Lu; John J Kerrigan; Maite De Los Frailes Alvaro; Bryan Laffitte; Wu-Schyong Liu; Joseph P Marino; Craig R Meyer; Jason A Nichols; Derek J Parks; Paloma Perez; Lea Sarov-Blat; Sheila D Seepersaud; Klaudia Steplewski; Scott K Thompson; Ping Wang; Michael A Watson; Christine L Webb; David Haigh; Justin A Caravella; Colin H Macphee; Timothy M Willson; Jon L Collins
Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.
Journal of medicinal chemistry 2005;48(17):5419-22.
2005: Ya-Ling Wu; Xiaojing Yang; Zhong Ren; Donald P McDonnell; John D Norris; Timothy M Willson; Geoffrey L Greene
Structural basis for an unexpected mode of SERM-mediated ER antagonism.
Molecular cell 2005;18(4):413-24.
2005: William J Zuercher; Stéphanie Gaillard; Lisa A Orband-Miller; Esther Y H Chao; Barry G Shearer; David G Jones; Aaron B Miller; Jon L Collins; Donald P McDonnell; Timothy M Willson
Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma.
Journal of medicinal chemistry 2005;48(9):3107-9.
2005: Stefano Fiorucci; Carlo Clerici; Elisabetta Antonelli; Stefano Orlandi; Bryan Goodwin; Bahman M Sadeghpour; Giuseppe Sabatino; Giuseppe Russo; Danilo Castellani; Timothy M Willson; Mark Pruzanski; Roberto Pellicciari; Antonio Morelli
Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis.
The Journal of pharmacology and experimental therapeutics 2005;313(2):604-12.
2005: William J Hoekstra; Hari S Patel; Xi Liang; Jean-Baptiste E Blanc; Dennis O Heyer; Timothy M Willson; Marie A Iannone; Sue H Kadwell; Lisa A Miller; Kenneth H Pearce; Catherine A Simmons; Jean Shearin
Discovery of novel quinoline-based estrogen receptor ligands using peptide interaction profiling.
Journal of medicinal chemistry 2005;48(6):2243-7.
2005: Irina N Krylova; Elena P Sablin; Jamie Moore; Robert X Xu; Gregory M Waitt; John Andrew Mackay; Dalia Juzumiene; Jane M Bynum; Kevin Madauss; Valerie G Montana; Lioudmila Lebedeva; Miyuki Suzawa; Jon D Williams; Shawn P Williams; Rodney K Guy; Joseph W Thornton; Robert J Fletterick; Timothy M Willson; Holly A Ingraham
Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
Cell 2005;120(3):343-55.
2004: Robert X Xu; Millard H Lambert; Bruce Wisely; Erin N Warren; Emily E Weinert; Gregory M Waitt; Jon D Williams; Jon L Collins; Linda B Moore; Timothy M Willson; John T Moore
A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.
Molecular cell 2004;16(6):919-28.
2004: Andrew C Li; Christoph J Binder; Alejandra Gutierrez; Kathleen K Brown; Christine R Plotkin; Jennifer W Pattison; Annabel F Valledor; Roger A Davis; Timothy M Willson; Joseph L Witztum; Wulf Palinski; Christopher K Glass
Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma.
The Journal of clinical investigation 2004;114(11):1564-76.
2004: Roberto Pellicciari; Gabriele Costantino; Emidio Camaioni; Bahman M Sadeghpour; Antonio Entrena; Timothy M Willson; Stefano Fiorucci; Carlo Clerici; Antimo Gioiello
Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid.
Journal of medicinal chemistry 2004;47(18):4559-69.
2004: Eugene L Stewart; Peter J Brown; James A Bentley; Timothy M Willson
Selection, application, and validation of a set of molecular descriptors for nuclear receptor ligands.
Combinatorial chemistry & high throughput screening 2004;7(5):407-12.
2004: Matthias Schmuth; Peter M Elias; Karen Hanley; Peggy Lau; A Moser; Timothy M Willson; Daniel David Bikle; Kenneth R Feingold
The effect of LXR activators on AP-1 proteins in keratinocytes.
The Journal of investigative dermatology 2004;123(1):41-8.
2004: Jodi M Maglich; Joe Watson; Patrick J McMillen; Bryan Goodwin; Timothy M Willson; John T Moore
The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.
The Journal of biological chemistry 2004;279(19):19832-8.
2004: Matthias Schmuth; Christopher Haqq; William J Cairns; Julie C Holder; Sheri Tinnell Dorsam; Sandra Chang; Peggy Lau; Ashley J Fowler; Gary Chuang; Arthur H Moser; Barbara E Brown; Man Mao-Qiang; Yoshikazu Uchida; Kristina Schoonjans; Johan Auwerx; P Chambon; Timothy M Willson; Peter M Elias; Kenneth R Feingold
Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes.
The Journal of investigative dermatology 2004;122(4):971-83.
2003: Shawn Williams; Randy K Bledsoe; Jon L Collins; Sharon Boggs; Millard H Lambert; Aaron B Miller; John Moore; David D McKee; Linda Moore; Jason Nichols; Derek Parks; Mike Watson; Bruce Wisely; Timothy M Willson
X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.
The Journal of biological chemistry 2003;278(29):27138-43.
2003: Jodi M Maglich; Justin A Caravella; Millard H Lambert; Timothy M Willson; John T Moore; Lakshman Ramamurthy
The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily.
Nucleic acids research 2003;31(14):4051-8.
2003: Andrew E Place; Nanjoo Suh; Charlotte R Williams; Renee Risingsong; Tadashi Honda; Yukiko Honda; Gordon W Gribble; Lisa M Leesnitzer; Julie B Stimmel; Timothy M Willson; Evan Rosen; Michael B. Sporn
The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(7):2798-806.
2003: Keith D Baker; Lisa M Shewchuk; Tatiana Kozlova; Makoto Makishima; Annie Hassell; Bruce Wisely; Justin A Caravella; Millard H Lambert; Jeffrey L Reinking; Henry Krause; Carl S Thummel; Timothy M Willson; David J Mangelsdorf
The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway.
Cell 2003;113(6):731-42.
2003: Andrew M Anisfeld; Heidi R Kast-Woelbern; Marie E Meyer; Stacey A Jones; Yanqiao Zhang; Kevin J Williams; Timothy M Willson; Peter A Edwards
Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor.
The Journal of biological chemistry 2003;278(22):20420-8.
2003: Jodi M Maglich; Derek J Parks; Linda B Moore; Jon L Collins; Bryan Goodwin; Andrew N Billin; Catherine A Stoltz; Steven A Kliewer; Millard H Lambert; Timothy M Willson; John T Moore
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.
The Journal of biological chemistry 2003;278(19):17277-83.
2003: Marcos L Sznaidman; Curt D Haffner; Patrick R Maloney; Adam M Fivush; Esther Chao; Donna Goreham; Michael L Sierra; Christelle LeGrumelec; H Eric Xu; Valerie G Montana; Millard H Lambert; Timothy M Willson; William R Oliver; Daniel D Sternbach
Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity.
Bioorganic & medicinal chemistry letters 2003;13(9):1517-21.
2003: Ashley J Fowler; MARY SHEU; Matthias Schmuth; Jack Kao; Joachim W Fluhr; Linda Rhein; Jon L Collins; Timothy M Willson; David J Mangelsdorf; Peter M Elias; Kenneth R Feingold
Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production.
The Journal of investigative dermatology 2003;120(2):246-55.
2002: Steven A Kliewer; Bryan Goodwin; Timothy M Willson
The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism.
Endocrine reviews 2002;23(5):687-702.
2002: G Bruce Wisely; Ann B Miller; Roderick G Davis; Alan D Thornquest; Robert Johnson; Tim Spitzer; Andrea Sefler; Barry G Shearer; John T Moore; Aaron B Miller; Timothy M Willson; Shawn P Williams
Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids.
Structure (London, England : 1993) 2002;10(9):1225-34.
2002: Roberto Pellicciari; Stefano Fiorucci; Emidio Camaioni; Carlo Clerici; Gabriele Costantino; Patrick R Maloney; Antonio Morelli; Derek J Parks; Timothy M Willson
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.
Journal of medicinal chemistry 2002;45(17):3569-72.
2002: Randy K Bledsoe; Valerie G Montana; Thomas B Stanley; Chris J Delves; Christopher J Apolito; David D McKee; Thomas G Consler; Derek J Parks; Eugene L Stewart; Timothy M Willson; Millard H Lambert; John T Moore; Kenneth H Pearce; H Eric Xu
Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.
Cell 2002;110(1):93-105.
2002: Timothy M Willson; John T Moore
Genomics versus orphan nuclear receptors--a half-time report.
Molecular endocrinology (Baltimore, Md.) 2002;16(6):1135-44.
2002: Sean B Joseph; Elaine McKilligin; Liming Pei; Michael A Watson; Alan R Collins; Bryan A Laffitte; Mingyi Chen; Grace Noh; Joanne Goodman; Graham N Hagger; Jonathan Tran; Timothy K Tippin; Xuping Wang; Aldons J Lusis; Willa A Hsueh; Ronald E Law; Jon L Collins; Timothy M Willson; Peter Tontonoz
Synthetic LXR ligand inhibits the development of atherosclerosis in mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(11):7604-9.
2002: Lisa M Leesnitzer; Derek J Parks; Randy K Bledsoe; Jeffery Cobb; Jon L Collins; Thomas G Consler; Roderick G Davis; Emily Hull-Ryde; James Lenhard; Lisa Patel; Kelli D Plunket; Jennifer L Shenk; Julie B Stimmel; Christina Therapontos; Timothy M Willson; Steven G Blanchard
Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.
Biochemistry 2002;41(21):6640-50.
2002: Jon L Collins; Adam M Fivush; Michael A Watson; Cristin M Galardi; Michael C Lewis; Linda B Moore; Derek J Parks; Joan G Wilson; Timothy K Tippin; Jane G Binz; Kelli D Plunket; Daniel G Morgan; Elizabeth J Beaudet; Karl D Whitney; Steven A Kliewer; Timothy M Willson
Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.
Journal of medicinal chemistry 2002;45(10):1963-6.
2002: Linda B Moore; Jodi M Maglich; David D McKee; Bruce Wisely; Timothy M Willson; Steven A Kliewer; Millard H Lambert; John T Moore
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors.
Molecular endocrinology (Baltimore, Md.) 2002;16(5):977-86.
2002: Steven A Kliewer; Timothy M Willson
Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor.
Journal of lipid research 2002;43(3):359-64.
2002: H Eric Xu; Thomas B Stanley; Valerie G Montana; Millard H Lambert; Barry G Shearer; Jeffery Cobb; David D McKee; Cristin M Galardi; Kelli D Plunket; Robert T Nolte; Derek J Parks; John T Moore; Steven A Kliewer; Timothy M Willson; Julie B Stimmel
Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha.
Nature 2002;415(6873):813-7.
2002: Heidi R Kast; Bryan Goodwin; Paul T Tarr; Stacey A Jones; Andrew M Anisfeld; Catherine M Stoltz; Peter Tontonoz; Steven A Kliewer; Timothy M Willson; Peter A Edwards
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
The Journal of biological chemistry 2002;277(4):2908-15.
2002: John T Moore; Bryan Goodwin; Timothy M Willson; Steven A Kliewer
Nuclear receptor regulation of genes involved in bile acid metabolism.
Critical reviews in eukaryotic gene expression 2002;12(2):119-35.
2001: KG Liu; Millard H Lambert; Andrea H Ayscue; Brad R Henke; Lisa M Leesnitzer; William R Oliver; Kelli D Plunket; H Eric Xu; Daniel D Sternbach; Timothy M Willson
Synthesis and biological activity of L-tyrosine-based PPARgamma agonists with reduced molecular weight.
Bioorganic & medicinal chemistry letters 2001;11(24):3111-3.
2001: Karl D Whitney; Michael A Watson; Bryan Goodwin; Cristin M Galardi; Jodi M Maglich; Joan G Wilson; Timothy M Willson; Jon L Collins; Steven A Kliewer
Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages.
The Journal of biological chemistry 2001;276(47):43509-15.
2001: H Eric Xu; Millard H Lambert; Valerie G Montana; Kelli D Plunket; Linda B Moore; Jon L Collins; JA Oplinger; Steven A Kliewer; Robert T Gampe; David D McKee; John T Moore; Timothy M Willson
Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(24):13919-24.
2001: KG Liu; Millard H Lambert; Lisa M Leesnitzer; William R Oliver; R J Ott; Kelli D Plunket; L W Stuart; PJ Brown; Timothy M Willson; Daniel D Sternbach
Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis.
Bioorganic & medicinal chemistry letters 2001;11(22):2959-62.
2001: Timothy M Willson; S A Jones; John T Moore; Steven A Kliewer
Chemical genomics: functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism.
Medicinal research reviews 2001;21(6):513-22.
2001: Heidi R Kast; CM Nguyen; Christopher J Sinal; Stacey A Jones; Bryan A Laffitte; Karen Reue; F J Gonzalez; Timothy M Willson; Peter A Edwards
Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids.
Molecular endocrinology (Baltimore, Md.) 2001;15(10):1720-8.
2001: KG Liu; Jennifer Smith; Andrea H Ayscue; Brad R Henke; Millard H Lambert; Lisa M Leesnitzer; Kelli D Plunket; Timothy M Willson; Daniel D Sternbach
Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPARalpha, PPARgamma, and PPARdelta.
Bioorganic & medicinal chemistry letters 2001;11(17):2385-8.
2001: James M Way; Cem Z Görgün; Q Tong; Teo Uysal; K K Brown; W W Harrington; W R Oliver; Timothy M Willson; Steven A Kliewer; Gökhan S Hotamisligil
Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists.
The Journal of biological chemistry 2001;276(28):25651-3.
2001: Ryan E Watkins; G Bruce Wisely; Linda B Moore; Jon L Collins; Millard H Lambert; Shawn P Williams; Timothy M Willson; Steven A Kliewer; Matthew R Redinbo
The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity.
Science (New York, N.Y.) 2001;292(5525):2329-33.
2001: PJ Brown; L W Stuart; K P Hurley; Michael C Lewis; Deborah Winegar; Joan G Wilson; William O Wilkison; Olivia R Ittoop; Timothy M Willson
Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis.
Bioorganic & medicinal chemistry letters 2001;11(9):1225-7.
2001: William R Oliver; Jennifer L Shenk; Michael Snaith; C S Russell; Kelli D Plunket; Noni L Bodkin; Michael C Lewis; Deborah Winegar; Marcos L Sznaidman; Millard H Lambert; H Eric Xu; Daniel D Sternbach; Steven A Kliewer; Barbara C Hansen; Timothy M Willson
A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5306-11.
2001: C E Connor; John D Norris; Gloria Broadwater; Timothy M Willson; M M Gottardis; Mark Dewhirst; Donald P McDonnell
Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor.
Cancer research 2001;61(7):2917-22.
2001: Thomas A Spencer; Dansu Li; Jonathon S Russel; Jon L Collins; Randy K Bledsoe; Thomas G Consler; Linda B Moore; Cristin M Galardi; David D McKee; John T Moore; Michael A Watson; Derek J Parks; Millard H Lambert; Timothy M Willson
Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha.
Journal of medicinal chemistry 2001;44(6):886-97.
2001: Jeff L Staudinger; Bryan Goodwin; Stacey A Jones; D Hawkins-Brown; K I MacKenzie; Anne M Latour; Yaping Liu; Curtis D Klaassen; K K Brown; J Reinhard; Timothy M Willson; Beverly H Koller; Steven A Kliewer
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3369-74.
2001: James M Way; W W Harrington; K K Brown; W K Gottschalk; Scott S Sundseth; Traci A Mansfield; R K Ramachandran; Timothy M Willson; Steven A Kliewer
Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues.
Endocrinology 2001;142(3):1269-77.
2001: Jodi M Maglich; A Sluder; X Guan; Y Shi; David D McKee; K Carrick; K Kamdar; Timothy M Willson; John T Moore
Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes.
Genome biology 2001;2(8):RESEARCH0029.
2000: Y Wang; W W Porter; Nanjoo Suh; Tadashi Honda; Gordon W Gribble; Lisa M Leesnitzer; Kelli D Plunket; D J Mangelsdorf; Steven G Blanchard; Timothy M Willson; Michael B. Sporn
A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma.
Molecular endocrinology (Baltimore, Md.) 2000;14(10):1550-6.
2000: Bryan Goodwin; Stacey A Jones; R R Price; Michael A Watson; David D McKee; Linda B Moore; Cristin M Galardi; Joan G Wilson; Michael C Lewis; M E Roth; Patrick R Maloney; Timothy M Willson; Steven A Kliewer
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.
Molecular cell 2000;6(3):517-26.
2000: Patrick R Maloney; Derek J Parks; Curt D Haffner; Adam M Fivush; G Chandra; Kelli D Plunket; K L Creech; Linda B Moore; Joan G Wilson; Michael C Lewis; Stacey A Jones; Timothy M Willson
Identification of a chemical tool for the orphan nuclear receptor FXR.
Journal of medicinal chemistry 2000;43(16):2971-4.
2000: Andrew C Li; K K Brown; MJ Silvestre; Timothy M Willson; Wulf Palinski; Christopher K Glass
Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice.
The Journal of clinical investigation 2000;106(4):523-31.
2000: Linda B Moore; Bryan Goodwin; Stacey A Jones; G Bruce Wisely; C J Serabjit-Singh; Timothy M Willson; Jon L Collins; Steven A Kliewer
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7500-2.
2000: Linda B Moore; Derek J Parks; Stacey A Jones; Randy K Bledsoe; Thomas G Consler; Julie B Stimmel; Bryan Goodwin; Christopher Liddle; Steven G Blanchard; Timothy M Willson; Jon L Collins; Steven A Kliewer
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.
The Journal of biological chemistry 2000;275(20):15122-7.
2000: Thomas A Spencer; Dansu Li; Jonathon S Russel; N C Tomkinson; Timothy M Willson
Further studies on the synthesis of 24(S),25-epoxycholesterol. A new, efficient preparation of desmosterol.
The Journal of organic chemistry 2000;65(7):1919-23.
2000: Robert T Gampe; Valerie G Montana; Millard H Lambert; Aaron B Miller; Randy K Bledsoe; MV Milburn; Steven A Kliewer; Timothy M Willson; H Eric Xu
Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.
Molecular cell 2000;5(3):545-55.
2000: Timothy M Willson; PJ Brown; Daniel D Sternbach; Brad R Henke
The PPARs: from orphan receptors to drug discovery.
Journal of medicinal chemistry 2000;43(4):527-50.
2000: Stacey A Jones; Linda B Moore; Jennifer L Shenk; G Bruce Wisely; Geraldine A Hamilton; David D McKee; NC Tomkinson; Edward LeCluyse; Millard H Lambert; Timothy M Willson; Steven A Kliewer; John T Moore
The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.
Molecular endocrinology (Baltimore, Md.) 2000;14(1):27-39.
1999: Brad R Henke; Kim K Adkison; Steven G Blanchard; Lisa M Leesnitzer; Robert A Mook; Kelli D Plunket; John A Ray; C Roberson; R Unwalla; Timothy M Willson
Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists.
Bioorganic & medicinal chemistry letters 1999;9(23):3329-34.
1999: Nanjoo Suh; Y Wang; Charlotte R Williams; Renee Risingsong; T Gilmer; Timothy M Willson; Michael B. Sporn
A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis.
Cancer research 1999;59(22):5671-3.
1999: Suzanne A W Fuqua; Rachel Schiff; Irma Parra; WE Friedrichs; Jui-Lan Su; David D McKee; KA Slentz-Kesler; Linda B Moore; Timothy M Willson; John T Moore
Expression of wild-type estrogen receptor beta and variant isoforms in human breast cancer.
Cancer research 1999;59(21):5425-8.
1999: PJ Brown; Deborah Winegar; Kelli D Plunket; Linda B Moore; Michael C Lewis; Joan G Wilson; Scott S Sundseth; C S Koble; Z Wu; J M Chapman; Jurgen Lehmann; Steven A Kliewer; Timothy M Willson
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.
Journal of medicinal chemistry 1999;42(19):3785-8.
1999: J T Huang; John S Welch; Mercedes Ricote; C J Binder; Timothy M Willson; C Kelly; Joseph L Witztum; Colin D Funk; Douglas J Conrad; Christopher K Glass
Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase.
Nature 1999;400(6742):378-82.
1999: Kathleen K Brown; Brad R Henke; Steven G Blanchard; Jeffery Cobb; Robert A Mook; Istvan Kaldor; Steven A Kliewer; Jurgen Lehmann; James Lenhard; W Wallace Harrington; P J Novak; Walter L Faison; Jane G Binz; Mir A Hashim; W O Oliver; H Roger Brown; Derek J Parks; Kelli D Plunket; WQ Tong; J A Menius; Kim K Adkison; S A Noble; Timothy M Willson
A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.
Diabetes 1999;48(7):1415-24.
1999: J L Oberfield; Jon L Collins; C P Holmes; D M Goreham; J P Cooper; Jeffery Cobb; James Lenhard; Emily Hull-Ryde; C P Mohr; Steven G Blanchard; Derek J Parks; Linda B Moore; Jurgen Lehmann; Kelli D Plunket; Aaron B Miller; MV Milburn; Steven A Kliewer; Timothy M Willson
A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6102-6.
1999: Derek J Parks; Steven G Blanchard; Randy K Bledsoe; G Chandra; Thomas G Consler; Steven A Kliewer; Julie B Stimmel; Timothy M Willson; Ann Marie Zavacki; David D Moore; Jurgen Lehmann
Bile acids: natural ligands for an orphan nuclear receptor.
Science (New York, N.Y.) 1999;284(5418):1365-8.
1999: Steven A Kliewer; Jurgen Lehmann; Timothy M Willson
Orphan nuclear receptors: shifting endocrinology into reverse.
Science (New York, N.Y.) 1999;284(5415):757-60.
1999: H Eric Xu; Millard H Lambert; Valerie G Montana; Derek J Parks; Steven G Blanchard; PJ Brown; Daniel D Sternbach; Jurgen Lehmann; G Bruce Wisely; Timothy M Willson; Steven A Kliewer; MV Milburn
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.
Molecular cell 1999;3(3):397-403.
1999: Steven A Kliewer; Jurgen Lehmann; MV Milburn; Timothy M Willson
The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways.
Recent progress in hormone research 1999;54():345-67; discussion 367-8.
1998: Derek J Parks; NC Tomkinson; M S Villeneuve; Steven G Blanchard; Timothy M Willson
Differential activity of rosiglitazone enantiomers at PPAR gamma.
Bioorganic & medicinal chemistry letters 1998;8(24):3657-8.
1998: Brad R Henke; Steven G Blanchard; M F Brackeen; Kathleen K Brown; Jeffery Cobb; Jon L Collins; W Wallace Harrington; Mir A Hashim; Emily Hull-Ryde; Istvan Kaldor; Steven A Kliewer; DH Lake; Lisa M Leesnitzer; Jurgen Lehmann; James Lenhard; Lisa A Orband-Miller; John F Miller; Robert A Mook; S A Noble; William R Oliver; Derek J Parks; Kelli D Plunket; J R Szewczyk; Timothy M Willson
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.
Journal of medicinal chemistry 1998;41(25):5020-36.
1998: Steven A Kliewer; Timothy M Willson
The nuclear receptor PPARgamma - bigger than fat.
Current opinion in genetics & development 1998;8(5):576-81.
1998: Robert T Nolte; G Bruce Wisely; S Westin; Jeffery Cobb; Millard H Lambert; R Kurokawa; Michael G Rosenfeld; Timothy M Willson; Christopher K Glass; MV Milburn
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma.
Nature 1998;395(6698):137-43.
1998: Jurgen Lehmann; David D McKee; Michael A Watson; Timothy M Willson; John T Moore; Steven A Kliewer
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
The Journal of clinical investigation 1998;102(5):1016-23.
1998: John T Moore; David D McKee; KA Slentz-Kesler; Linda B Moore; Stacey A Jones; Earnest Horne; Jui-Lan Su; Steven A Kliewer; Jurgen Lehmann; Timothy M Willson
Cloning and characterization of human estrogen receptor beta isoforms.
Biochemical and biophysical research communications 1998;247(1):75-8.
1998: Steven A Kliewer; John T Moore; L Wade; Jeff L Staudinger; Michael A Watson; Stacey A Jones; David D McKee; BB Oliver; Timothy M Willson; R H Zetterström; Thomas Perlmann; Jurgen Lehmann
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.
Cell 1998;92(1):73-82.
1998: Mercedes Ricote; Andrew C Li; Timothy M Willson; Carolyn J Kelly; Christopher K Glass
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation.
Nature 1998;391(6662):79-82.
1997: PJ Brown; T A Smith-Oliver; PS Charifson; NC Tomkinson; Adam M Fivush; Daniel D Sternbach; L E Wade; Lisa A Orband-Miller; Derek J Parks; Steven G Blanchard; Steven A Kliewer; Jurgen Lehmann; Timothy M Willson
Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library.
Chemistry & biology 1997;4(12):909-18.
1997: Timothy M Willson; John D Norris; BL Wagner; I Asplin; P Baer; H R Brown; Stacey A Jones; Brad R Henke; H Sauls; S Wolfe; DC Morris; Donald P McDonnell
Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone.
Endocrinology 1997;138(9):3901-11.
1997: Brad R Henke; C J Aquino; LS Birkemo; D K Croom; R W Dougherty; GN Ervin; M K Grizzle; G C Hirst; M K James; MF Johnson; K L Queen; R G Sherrill; EE Sugg; E M Suh; J W Szewczyk; R J Unwalla; J Yingling; Timothy M Willson
Optimization of 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines as potent, orally active CCK-A agonists.
Journal of medicinal chemistry 1997;40(17):2706-25.
1997: Ann Marie Zavacki; Jurgen Lehmann; W Seol; Timothy M Willson; Steven A Kliewer; David D Moore
Activation of the orphan receptor RIP14 by retinoids.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):7909-14.
1997: Steven A Kliewer; Scott S Sundseth; Stacey A Jones; PJ Brown; G Bruce Wisely; C S Koble; P Devchand; W Wahli; Timothy M Willson; James Lenhard; Jurgen Lehmann
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4318-23.
1997: Jurgen Lehmann; Steven A Kliewer; Linda B Moore; T A Smith-Oliver; BB Oliver; Jui-Lan Su; Scott S Sundseth; Deborah Winegar; D E Blanchard; Thomas A Spencer; Timothy M Willson
Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway.
The Journal of biological chemistry 1997;272(6):3137-40.
1996: Timothy M Willson; Jurgen Lehmann; Steven A Kliewer
Discovery of ligands for the nuclear peroxisome proliferator-activated receptors.
Annals of the New York Academy of Sciences 1996;804():276-83.
1996: G C Hirst; C Aquino; LS Birkemo; D K Croom; M Dezube; R W Dougherty; G N Ervin; M K Grizzle; Brad R Henke; M K James; M F Johnson; T Momtahen; K L Queen; R G Sherrill; J Szewczyk; Timothy M Willson; E E Sugg
Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity (II): Optimization of the C3 amino substituent.
Journal of medicinal chemistry 1996;39(26):5236-45.
1996: Timothy M Willson; Brad R Henke; T M Momtahen; P L Myers; E E Sugg; R J Unwalla; D K Croom; R W Dougherty; M K Grizzle; M F Johnson; K L Queen; thomas rimele; J D Yingling; M K James
3-[2-(N-phenylacetamide)]-1,5-benzodiazepines: orally active, binding selective CCK-A agonists.
Journal of medicinal chemistry 1996;39(15):3030-4.
1996: Brad R Henke; Timothy M Willson; E E Sugg; D K Croom; R W Dougherty; K L Queen; LS Birkemo; G N Ervin; M K Grizzle; M F Johnson; M K James
3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines: CCK-A agonists that demonstrate oral activity as satiety agents.
Journal of medicinal chemistry 1996;39(14):2655-8.
1996: Timothy M Willson; Jeffery Cobb; D J Cowan; R W Wiethe; I D Correa; S R Prakash; K D Beck; Linda B Moore; Steven A Kliewer; Jurgen Lehmann
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones.
Journal of medicinal chemistry 1996;39(3):665-8.
1995: Steven A Kliewer; James Lenhard; Timothy M Willson; I Patel; D C Morris; Jurgen Lehmann
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation.
Cell 1995;83(5):813-9.
1995: Jurgen Lehmann; Linda B Moore; T A Smith-Oliver; W O Wilkison; Timothy M Willson; Steven A Kliewer
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).
The Journal of biological chemistry 1995;270(22):12953-6.
1994: Timothy M Willson; Brad R Henke; T M Momtahen; PS Charifson; K W Batchelor; D B Lubahn; Linda B Moore; B B Oliver; H R Sauls; J A Triantafillou
3-[4-(1,2-Diphenylbut-1-enyl)phenyl]acrylic acid: a non-steroidal estrogen with functional selectivity for bone over uterus in rats.
Journal of medicinal chemistry 1994;37(11):1550-2.