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Ian Wilson

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Nick S Laursen; Ian A Wilson
Broadly neutralizing antibodies against influenza viruses.
Joseph Jardine; Meaghan Jones; Jean-Philippe Julien; Oleksandr Kalyuzhniy; Skye MacPherson; John C Mathison; Andrew McGuire; Sergey Menis; David Nemazee; Travis Nieusma; Takayuki Ota; Devin Sok; Leonidas Stamatatos; Andrew B Ward; Ian A Wilson; David Baker; Dennis R Burton; Po-Ssu Huang; William R Schief
Rational HIV immunogen design to target specific germline B cell receptors.
Jean-Philippe Julien; Umesh Katpally; Reza Khayat; Jeong Hyun Lee; Andre J Marozsan; Ryan McBride; John P Moore; James C Paulson; Robert Pejchal; Pascal Poignard; Alejandra Ramos; Rogier W Sanders; Devin Sok; Robyn L Stanfield; Laura M Walker; Andrew B Ward; Dennis R Burton; Albert Cupo; Rafael S Depetris; Devan C Diwanji; Katie J Doores; Ian A Wilson
Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans.

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All Publications

2013: Nick S Laursen; Ian A Wilson
Broadly neutralizing antibodies against influenza viruses.
Antiviral research 2013;98(3):476-83.
2013: Joseph Jardine; Meaghan Jones; Jean-Philippe Julien; Oleksandr Kalyuzhniy; Skye MacPherson; John C Mathison; Andrew McGuire; Sergey Menis; David Nemazee; Travis Nieusma; Takayuki Ota; Devin Sok; Leonidas Stamatatos; Andrew B Ward; Ian A Wilson; David Baker; Dennis R Burton; Po-Ssu Huang; William R Schief
Rational HIV immunogen design to target specific germline B cell receptors.
Science (New York, N.Y.) 2013;340(6133):711-6.
2013: Jean-Philippe Julien; Umesh Katpally; Reza Khayat; Jeong Hyun Lee; Andre J Marozsan; Ryan McBride; John P Moore; James C Paulson; Robert Pejchal; Pascal Poignard; Alejandra Ramos; Rogier W Sanders; Devin Sok; Robyn L Stanfield; Laura M Walker; Andrew B Ward; Dennis R Burton; Albert Cupo; Rafael S Depetris; Devan C Diwanji; Katie J Doores; Ian A Wilson
Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans.
PLoS pathogens 2013;9(5):e1003342.
2013: Neil P Grimster; Aleksandra Baranczak; Stephen Connelly; Jiajia Dong; Larissa Krasnova; Evan T Powers; K Barry Sharpless; Ian A Wilson; Jeffery W Kelly
Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate.
Journal of the American Chemical Society 2013;135(15):5656-68.
2013: Feng Wang; Ian A Wilson; Yong Zhang; Xueyong Zhu; Insha Ahmad; Thomas J Magliery; Shiladitya Sen; Vaughn Smider; Peter G Schultz
Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(11):4261-6.
2013: Jean-Philippe Julien; C Richter King; Per Johan Klasse; Jeong Hyun Lee; Andre J Marozsan; John P Moore; Charles D Murin; Rogier W Sanders; Michael J Caulfield; Albert Cupo; Ronald Derking; Simon Hoffenberg; Ian A Wilson; Andrew B Ward
Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(11):4351-6.
2013: Rui Xu; James E Crowe; Jens C Krause; Ryan McBride; James C Paulson; Ian A Wilson
A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin.
Nature structural & molecular biology 2013;20(3):363-70.
2013: Andrew B Ward; Andrej Sali; Ian A Wilson
Biochemistry. Integrative structural biology.
Science (New York, N.Y.) 2013;339(6122):913-5.
2013: Xueyong Zhu; Wenli Yu; Li-Mei Chen; Ruben O Donis; Yan Li; Ryan McBride; James C Paulson; Suxiang Tong; Ian A Wilson
Hemagglutinin homologue from H17N10 bat influenza virus exhibits divergent receptor-binding and pH-dependent fusion activities.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(4):1458-63.
2012: Arne Moeller; Clinton Potter; Bridget Carragher; Robert N Kirchdoerfer; Ian A Wilson
Organization of the influenza virus replication machinery.
Science (New York, N.Y.) 2012;338(6114):1631-4.
2012: Xueyong Zhu; Hua Yang; Wenli Yu; Paul J Carney; Li-Mei Chen; Ruben O Donis; Zhu Guo; Yan Li; James C Paulson; James Stevens; Suxiang Tong; Ian A Wilson
Crystal structures of two subtype N10 neuraminidase-like proteins from bat influenza A viruses reveal a diverged putative active site.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(46):18903-8.
2012: Jean-Philippe Julien; Peter S Lee; Ian A Wilson
Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.
Immunological reviews 2012;250(1):180-98.
2012: Anette Schneemann; Jeffrey A Speir; Gene S Tan; Damian C Ekiert; Reza Khayat; Yumiko Matsuoka; Ian A Wilson
A virus-like particle that elicits cross-reactive antibodies to the conserved stem of influenza virus hemagglutinin.
Journal of virology 2012;86(21):11686-97.
2012: Dennis R Burton; Salvatore T Butera; Shane Crotty; Adam Godzik; Daniel E Kaufmann; M Juliana McElrath; Michel C Nussenzweig; Bali Pulendran; Chris N Scanlan; William R Schief; Guido Silvestri; Hendrik Streeck; Bruce D Walker; Laura M Walker; Andrew B Ward; Ian A Wilson; Rafi Ahmed; Dan H Barouch; Richard Wyatt
A Blueprint for HIV Vaccine Discovery.
Cell host & microbe 2012;12(4):396-407.
2012: Peter S Lee; Naoki Sakai; Yasuhiko Suzuki; Ayato Takada; Damian C Ekiert; Reiko Yoshida; Ian A Wilson
Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(42):17040-5.
2012: Minsun Hong; Sung-Il Yoon; Ian A Wilson
Recombinant expression of TLR5 proteins by ligand supplementation and a leucine-rich repeat hybrid technique.
Biochemical and biophysical research communications 2012;427(1):119-24.
2012: Damian C Ekiert; Aleksandr M Faynboym; Lawrence Horowitz; Michael Horowitz; Arun K Kashyap; Reza Khayat; Jeong Hyun Lee; Richard A Lerner; Ryann E O'Neil; Peter Palese; Adam Rubrum; John Steel; Andrew B Ward; Richard Webby; Gira Bhabha; Ramesh Bhatt; Michael A Dillon; Ian A Wilson
Cross-neutralization of influenza A viruses mediated by a single antibody loop.
Nature 2012;489(7417):526-32.
2012: Hongkai Zhang; Ian A Wilson; Richard A Lerner
Selection of antibodies that regulate phenotype from intracellular combinatorial antibody libraries.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(39):15728-33.
2012: Bethany A Buck-Koehntop; H Jane Dyson; Damian C Ekiert; Maria A Martinez-Yamout; Robyn L Stanfield; Ian A Wilson; Peter E Wright
Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(38):15229-34.
2012: Cyrille Dreyfus; Damian C Ekiert; Just P J Brakenhoff; Miriam V Bujny; Eric Geelen; Jaap Goudsmit; Mandy Jongeneelen; Reza Khayat; Hans J W M Korse; Wouter Koudstaal; Ted Kwaks; Mohammed Lamrani; Nick S Laursen; Jeong Hyun Lee; Olive T W Li; Zoltan Metlagel; Malik Peiris; Leo L M Poon; Özcan Sahin; Martijn Sieuwerts; Remko van der Vlugt; Ronald Vogels; Andrew B Ward; Ian A Wilson; David Zuijdgeest; Robert H E Friesen
Highly conserved protective epitopes on influenza B viruses.
Science (New York, N.Y.) 2012;337(6100):1343-8.
2012: Shridhar Bale; Zachary A Bornholdt; Peter Halfmann; Jean-Philippe Julien; Yoshihiro Kawaoka; Christopher R Kimberlin; Gerard J A Kroon; John Kunert; Ian J MacRae; Ian A Wilson; Michelle A Zandonatti; Erica Ollmann Saphire
Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism.
PLoS pathogens 2012;8(9):e1002916.
2012: Deborah A Witherden; Shane J F Cronin; Wolfgang H Fischer; Olivia Garijo; Hitoshi Kikutani; Atsushi Kumanogoh; Stephanie E Rieder; Gor Sarkisyan; Luc Teyton; Petra Verdino; Megumi Watanabe; Ian A Wilson; Wendy L Havran
The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal γδ T cell function.
Immunity 2012;37(2):314-25.
2012: Dennis R Burton; Pascal Poignard; Robyn L Stanfield; Ian A Wilson
Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses.
Science (New York, N.Y.) 2012;337(6091):183-6.
2012: Christine E Bulawa; Stephen Connelly; Michael Devit; James A Fleming; Ted R Foss; Jeffery W Kelly; Jeff Packman; Evan T Powers; Lan Wang; Charlotte Weigel; Ian A Wilson; R Luke Wiseman; Richard Labaudinière
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(24):9629-34.
2012: Leopold Kong; Dennis R Burton; Erick Giang; Justin B Robbins; Robyn L Stanfield; Ian A Wilson; Mansun Law
Structural basis of hepatitis C virus neutralization by broadly neutralizing antibody HCV1.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(24):9499-504.
2012: Qingping Xu; Dennis Carlton; Hsiu-Ju Chiu; Ashley M Deacon; Marc-André Elsliger; Adam Godzik; Anna-Katharina Göhler; Knut Jahreis; Heath E Klock; Mark W Knuth; Anne Kosfeld; Scott A Lesley; Mitchell D Miller; Ian A Wilson
The structure of Mlc titration factor A (MtfA/YeeI) reveals a prototypical zinc metallopeptidase related to anthrax lethal factor.
Journal of bacteriology 2012;194(11):2987-99.
2012: Corwin M Nycholat; Damian C Ekiert; Michel Gilbert; Ryan McBride; Wenjie Peng; Janani Rangarajan; Nahid Razi; Warren W Wakarchuk; Ian A Wilson; Rui Xu; James C Paulson
Recognition of sialylated poly-N-acetyllactosamine chains on N- and O-linked glycans by human and avian influenza A virus hemagglutinins.
Angewandte Chemie (International ed. in English) 2012;51(20):4860-3.
2012: Damian C Ekiert; Ian A Wilson
Broadly neutralizing antibodies against influenza virus and prospects for universal therapies.
Current opinion in virology 2012;2(2):134-41.
2012: Minsun Hong; Sung-il Yoon; Ian A Wilson
Structure and functional characterization of the RNA-binding element of the NLRX1 innate immune modulator.
Immunity 2012;36(3):337-47.
2012: Robert N Kirchdoerfer; Charles L Turnbough; Max D Cooper; Byung Woo Han; Brantley R Herrin; Ian A Wilson
Variable lymphocyte receptor recognition of the immunodominant glycoprotein of Bacillus anthracis spores.
Structure (London, England : 1993) 2012;20(3):479-86.
2012: Sung-il Yoon; Andrei V Gudkov; Minsun Hong; Oleg Kurnasov; Venkatesh Natarajan; Andrei Osterman; Ian A Wilson
Structural basis of TLR5-flagellin recognition and signaling.
Science (New York, N.Y.) 2012;335(6070):859-64.
2012: Qingping Xu; Hsiu-Ju Chiu; Beat Christen; Ashley M Deacon; Marc-André Elsliger; David H Figurski; Adam Godzik; Lukasz Jaroszewski; Heath E Klock; Mark W Knuth; Scott A Lesley; Mitchell D Miller; Lucy Shapiro; Ian A Wilson
Structure of the pilus assembly protein TadZ from Eubacterium rectale: implications for polar localization.
Molecular microbiology 2012;83(4):712-27.
2012: Tshidi Tsibane; Ian A Wilson; James E Crowe; Damian C Ekiert; Jens C Krause; Osvaldo Martinez; Christopher F Basler
Influenza human monoclonal antibody 1F1 interacts with three major antigenic sites and residues mediating human receptor specificity in H1N1 viruses.
PLoS pathogens 2012;8(12):e1003067.
2012: Abhinav Kumar; Scott A Lesley; Sabine Möcklinghoff; Phuong Nguyen; Christian X Weichenberger; Fumiaki Yumoto; Hsiu-Ju Chiu; Bruce R Conklin; Ashley M Deacon; Marc-André Elsliger; Carol L Farr; Robert J Fletterick; Adam Godzik; Anna Grzechnik; Lukasz Jaroszewski; Heath E Klock; Ian A Wilson
Structure of a novel winged-helix like domain from human NFRKB protein.
PloS one 2012;7(9):e43761.
2012: Qingping Xu; Hsiu-Ju Chiu; Ashley M Deacon; Marc-André Elsliger; Adam Godzik; Lukasz Jaroszewski; Heath E Klock; Mark W Knuth; Scott A Lesley; Mitchell D Miller; Gilles P van Wezel; Ian A Wilson
Structure of an MmyB-like regulator from C. aurantiacus, member of a new transcription factor family linked to antibiotic metabolism in actinomycetes.
PloS one 2012;7(7):e41359.
2011: Robyn L Stanfield; Johannes Gach; Jean-Philippe Julien; Robert Pejchal; Michael B Zwick; Ian A Wilson
Structure-based design of a protein immunogen that displays an HIV-1 gp41 neutralizing epitope.
Journal of molecular biology 2011;414(3):460-76.
2011: Laura M Walker; Sheng-Kai Wang; Ian A Wilson; Chi-Huey Wong; Terri Wrin; Alejandra Ramos; Melissa D Simek; Dennis R Burton; Po-Ying Chan-Hui; Katie J Doores; Emilia Falkowska; Steven Fling; Phillip W Hammond; Michael Huber; Jean-Philippe Julien; Wayne C Koff; Jennifer L Mitcham; Matthew Moyle; Ole A Olsen; Robert Pejchal; Sanjay Phogat; Pham Phung; Pascal Poignard
Broad neutralization coverage of HIV by multiple highly potent antibodies.
Nature 2011;477(7365):466-70.
2011: Sung-il Yoon; Minsun Hong; Ian A Wilson
An unusual dimeric structure and assembly for TLR4 regulator RP105-MD-1.
Nature structural & molecular biology 2011;18(9):1028-35.
2011: Anne G Kasmar; Luis Leon; John D Altman; John W Annand; Michael Brenner; Tan-Yun Cheng; Annemieke de Jong; Ravi C Kalathur; Andre Schiefner; Chetan Seshadri; John Shires; Marie Turner; Ildiko Van Rhijn; Ian A Wilson; D Branch Moody
CD1b tetramers bind αβ T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans.
The Journal of experimental medicine 2011;208(9):1741-7.
2011: Damian C Ekiert; Robert H E Friesen; Gira Bhabha; Just P J Brakenhoff; Boerries Brandenburg; Lisette A H M Cornelissen; Freek Cox; Mandy Jongeneelen; Martin H Koldijk; Ronald Kompier; Hans J W M Korse; Wouter Koudstaal; Ted Kwaks; C Ophorst; Malik Peiris; Leo L M Poon; Ronald Vogels; Ian A Wilson; Wenli Yu; Jaap Goudsmit
A highly conserved neutralizing epitope on group 2 influenza A viruses.
Science (New York, N.Y.) 2011;333(6044):843-50.
2011: Gye Won Han; Jaeju Ko; Scott A Lesley; Mitchell D Miller; Penny J Beuning; Hsiu-Ju Chiu; Ashley M Deacon; Marc C Deller; Marc-André Elsliger; Carol L Farr; Adam Godzik; Jana Sefcikova; Srinivas Somarowthu; Ian A Wilson; Qingping Xu; Mary Jo Ondrechen
Crystal structure of a metal-dependent phosphoesterase (YP_910028.1) from Bifidobacterium adolescentis: Computational prediction and experimental validation of phosphoesterase activity.
Proteins 2011;79(7):2146-60.
2011: Rui Xu; Ian A Wilson
Structural characterization of an early fusion intermediate of influenza virus hemagglutinin.
Journal of virology 2011;85(10):5172-82.
2011: Gira Bhabha; Jeeyeon Lee; Damian C Ekiert; Jongsik Gam; Ian A Wilson; H Jane Dyson; Stephen J Benkovic; Peter E Wright
A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis.
Science (New York, N.Y.) 2011;332(6026):234-8.
2011: Petra Verdino; Deborah A Witherden; M Sharon Ferguson; Adam L Corper; André Schiefner; Wendy L Havran; Ian A Wilson
Molecular insights into γδ T cell costimulation by an anti-JAML antibody.
Structure (London, England : 1993) 2011;19(1):80-9.
2011: Qingping Xu; Hsiu-Ju Chiu; Ashley M Deacon; Marc-André Elsliger; Adam Godzik; Lukasz Jaroszewski; Heath E Klock; Mark W Knuth; Scott A Lesley; Mitchell D Miller; Neil D Rawlings; Ian A Wilson
Structural analysis of papain-like NlpC/P60 superfamily enzymes with a circularly permuted topology reveals potential lipid binding sites.
PloS one 2011;6(7):e22013.
2011: Qingping Xu; Hsiu-Ju Chiu; Ashley M Deacon; Marc-André Elsliger; Carol L Farr; Adam Godzik; Joanna C Grant; Lukasz Jaroszewski; Heath E Klock; Mark W Knuth; Scott A Lesley; Mitchell D Miller; Neil D Rawlings; Dana Weekes; Ian A Wilson
Structural and sequence analysis of imelysin-like proteins implicated in bacterial iron uptake.
PloS one 2011;6(7):e21875.
2011: Petra Verdino; Deborah A Witherden; Katie Podshivalova; Stephanie E Rieder; Wendy L Havran; Ian A Wilson
cDNA sequence and Fab crystal structure of HL4E10, a hamster IgG lambda light chain antibody stimulatory for γδ T cells.
PloS one 2011;6(5):e19828.
2010: Taia T Wang; Gene S Tan; Hai Rong; Natalie Pica; Lily Ngai; Damian C Ekiert; Ian A Wilson; Adolfo García-Sastre; Thomas M Moran; Peter Palese
Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(44):18979-84.
2010: Katie J Doores; Zara Fulton; Vu Hong; Mitul K Patel; Christopher N Scanlan; Mark R Wormald; M G Finn; Dennis R Burton; Ian A Wilson; Benjamin G Davis
A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(40):17107-12.
2010: Pedro Serrano; Bill Pedrini; Michael Geralt; Kristaps Jaudzems; Biswaranjan Mohanty; Reto Horst; Torsten Herrmann; Marc-André Elsliger; Ian A Wilson; Kurt Wüthrich
Comparison of NMR and crystal structures highlights conformational isomerism in protein active sites.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 10):1393-405.
2010: Biswaranjan Mohanty; Pedro Serrano; Bill Pedrini; Kristaps Jaudzems; Michael Geralt; Reto Horst; Torsten Herrmann; Marc-André Elsliger; Ian A Wilson; Kurt Wüthrich
Comparison of NMR and crystal structures for the proteins TM1112 and TM1367.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 10):1381-92.
2010: Kristaps Jaudzems; Michael Geralt; Pedro Serrano; Biswaranjan Mohanty; Reto Horst; Bill Pedrini; Marc-André Elsliger; Ian A Wilson; Kurt Wüthrich
NMR structure of the protein NP_247299.1: comparison with the crystal structure.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 10):1367-80.
2010: Michael Huber; Khoa M Le; Katie J Doores; Zara Fulton; Robyn L Stanfield; Ian A Wilson; Dennis R Burton
Very few substitutions in a germ line antibody are required to initiate significant domain exchange.
Journal of virology 2010;84(20):10700-7.
2010: Katie J Doores; Zara Fulton; Michael Huber; Ian A Wilson; Dennis R Burton
Antibody 2G12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the HIV-1 glycan shield if domain exchanged.
Journal of virology 2010;84(20):10690-9.
2010: Petra Verdino; Deborah A Witherden; Wendy L Havran; Ian A Wilson
The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K.
Science (New York, N.Y.) 2010;329(5996):1210-4.
2010: Deborah A Witherden; Petra Verdino; Stephanie E Rieder; Olivia Garijo; Robyn E Mills; Luc Teyton; Wolfgang H Fischer; Ian A Wilson; Wendy L Havran
The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation.
Science (New York, N.Y.) 2010;329(5996):1205-10.
2010: Robert Pejchal; Laura M Walker; Robyn L Stanfield; Sanjay K Phogat; Wayne C Koff; Pascal Poignard; Dennis R Burton; Ian A Wilson
Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(25):11483-8.
2010: Sung-il Yoon; Minsun Hong; Gye Won Han; Ian A Wilson
Crystal structure of soluble MD-1 and its interaction with lipid IVa.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(24):10990-5.
2010: Kenji Yoshida; Adam L Corper; Rana Herro; Bana Jabri; Ian A Wilson; Luc Teyton
The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity.
The Journal of clinical investigation 2010;120(5):1578-90.
2010: Rui Xu; Damian C Ekiert; Jens C Krause; Hai Rong; James E Crowe; Ian A Wilson
Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus.
Science (New York, N.Y.) 2010;328(5976):357-60.
2010: Sungwook Choi; Natàlia Reixach; Stephen Connelly; Steven M Johnson; Ian A Wilson; Jeffery W Kelly
A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.
Journal of the American Chemical Society 2010;132(4):1359-70.
2010: Stephen Connelly; Sungwook Choi; Steven M Johnson; Jeffery W Kelly; Ian A Wilson
Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses.
Current opinion in structural biology 2010;20(1):54-62.
2010: Sungwook Choi; Stephen Connelly; Natàlia Reixach; Ian A Wilson; Jeffery W Kelly
Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
Nature chemical biology 2010;6(2):133-9.
2010: Rui Xu; Ryan McBride; James C Paulson; Christopher F Basler; Ian A Wilson
Structure, receptor binding, and antigenicity of influenza virus hemagglutinins from the 1957 H2N2 pandemic.
Journal of virology 2010;84(4):1715-21.
2010: Robert Pejchal; Ian A Wilson
Structure-based vaccine design in HIV: blind men and the elephant?
Current pharmaceutical design 2010;16(33):3744-53.
2009: Xueyong Zhu; Fujie Tanaka; Richard A Lerner; Carlos F Barbas; Ian A Wilson
Direct observation of an enamine intermediate in amine catalysis.
Journal of the American Chemical Society 2009;131(51):18206-7.
2009: Elise Landais; Pablo A Romagnoli; Adam L Corper; John Shires; John D Altman; Ian A Wilson; K Christopher Garcia; Luc Teyton
New design of MHC class II tetramers to accommodate fundamental principles of antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):7949-57.
2009: André Schiefner; Masakazu Fujio; Douglass Wu; Chi-Huey Wong; Ian A Wilson
Structural evaluation of potent NKT cell agonists: implications for design of novel stimulatory ligands.
Journal of molecular biology 2009;394(1):71-82.
2009: Erik W Debler; Roger Müller; Donald Hilvert; Ian A Wilson
An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(44):18539-44.
2009: Robert Pejchal; Johannes Gach; Florence Brunel; Rosa M F Cardoso; Robyn L Stanfield; Philip E Dawson; Dennis R Burton; Michael B Zwick; Ian A Wilson
A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies.
Journal of virology 2009;83(17):8451-62.
2009: Yu An; Christine Y Chen; Bryan D Moyer; Piotr Rotkiewicz; Marc-André Elsliger; Adam Godzik; Ian A Wilson; William E Balch
Structural and functional analysis of the globular head domain of p115 provides insight into membrane tethering.
Journal of molecular biology 2009;391(1):26-41.
2009: Damian C Ekiert; Gira Bhabha; Marc-André Elsliger; Robert H E Friesen; Mandy Jongeneelen; Mark Throsby; Jaap Goudsmit; Ian A Wilson
Antibody recognition of a highly conserved influenza virus epitope.
Science (New York, N.Y.) 2009;324(5924):246-51.
2009: Steven M Johnson; Stephen Connelly; Ian A Wilson; Jeffery W Kelly
Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
Journal of medicinal chemistry 2009;52(4):1115-25.
2009: Wei Wang; Alla Fridman; William Blackledge; Stephen Connelly; Ian A Wilson; Renate B Pilz; Gerry R Boss
The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis.
The Journal of biological chemistry 2009;284(6):3521-8.
2009: André Schiefner; Ian A Wilson
Presentation of lipid antigens by CD1 glycoproteins.
Current pharmaceutical design 2009;15(28):3311-7.
2009: Maximiliano J Jimenez-Dalmaroni; Nengming Xiao; Adam L Corper; Petra Verdino; Gary D Ainge; Dave S Larsen; Gavin F Painter; Pauline M Rudd; Raymond A Dwek; Kasper Hoebe; Bruce Beutler; Ian A Wilson
Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2.
PloS one 2009;4(10):e7411.
2008: David A Shore; H Issafras; E Landais; Luc Teyton; Ian A Wilson
The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I.
Journal of molecular biology 2008;384(5):1190-202.
2008: Dirk Zajonc; Harald Striegl; Christopher Dascher; Ian A Wilson
The crystal structure of avian CD1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian CD1.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(46):17925-30.
2008: Xiaojin Xu; Xueyong Zhu; Raymond A Dwek; James Stevens; Ian A Wilson
Structural characterization of the 1918 influenza virus H1N1 neuraminidase.
Journal of virology 2008;82(21):10493-501.
2008: Steven M Johnson; Stephen Connelly; Ian A Wilson; Jeffery W Kelly
Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
Journal of medicinal chemistry 2008;51(20):6348-58.
2008: Byung Woo Han; Brantley R Herrin; Max D Cooper; Ian A Wilson
Antigen recognition by variable lymphocyte receptors.
Science (New York, N.Y.) 2008;321(5897):1834-7.
2008: James Stevens; Ola Blixt; Li-Mei Chen; Ruben O Donis; James C Paulson; Ian A Wilson
Recent avian H5N1 viruses exhibit increased propensity for acquiring human receptor specificity.
Journal of molecular biology 2008;381(5):1382-94.
2008: Petra Verdino; Caroline Aldag; Donald Hilvert; Ian A Wilson
Closely related antibody receptors exploit fundamentally different strategies for steroid recognition.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11725-30.
2008: Xueyong Zhu; Xiaojin Xu; Ian A Wilson
Structure determination of the 1918 H1N1 neuraminidase from a crystal with lattice-translocation defects.
Acta crystallographica. Section D, Biological crystallography 2008;D64(Pt 8):843-50.
2008: Amandeep K Dhillon; Robyn L Stanfield; Miroslaw K Gorny; Constance Williams; Susan Zolla-Pazner; Ian A Wilson
Structure determination of an anti-HIV-1 Fab 447-52D-peptide complex from an epitaxially twinned data set.
Acta crystallographica. Section D, Biological crystallography 2008;D64(Pt 7):792-802.
2008: Rena D Astronomo; Hing-Ken Lee; Christopher N Scanlan; Ralph Pantophlet; Cheng-Yuan Huang; Ian A Wilson; Ola Blixt; Raymond A Dwek; Chi-Huey Wong; Dennis R Burton
A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120.
Journal of virology 2008;82(13):6359-68.
2008: Erik W Debler; Roger Müller; Donald Hilvert; Ian A Wilson
Conformational isomerism can limit antibody catalysis.
The Journal of biological chemistry 2008;283(24):16554-60.
2008: Miguel Relloso; Tan-Yun Cheng; Jin S Im; Emilio Parisini; Carme Roura-Mir; Charles DeBono; Dirk M Zajonc; Leonel F Murga; Mary Jo Ondrechen; Ian A Wilson; Steven A Porcelli; D Branch Moody
pH-dependent interdomain tethers of CD1b regulate its antigen capture.
Immunity 2008;28(6):774-86.
2008: Alfredo Menendez; Daniel A Calarese; Robyn L Stanfield; Keith C Chow; Chris N Scanlan; Renate Kunert; Herman Katinger; Dennis R Burton; Ian A Wilson; jamie scott
A peptide inhibitor of HIV-1 neutralizing antibody 2G12 is not a structural mimic of the natural carbohydrate epitope on gp120.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(5):1380-92.
2008: Dirk Zajonc; Paul B Savage; Albert Bendelac; Ian A Wilson; Luc Teyton
Crystal structures of mouse CD1d-iGb3 complex and its cognate Valpha14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids.
Journal of molecular biology 2008;377(4):1104-16.
2008: Erik W Debler; Gunnar Kaufmann; Michael M Meijler; Andreas Heine; Jenny M Mee; Goran Pljevaljcic; Angel Jorge Di Bilio; Peter G Schultz; David P Millar; Kim D Janda; Ian A Wilson; Harry B Gray; Richard A Lerner
Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex.
Science (New York, N.Y.) 2008;319(5867):1232-5.
2008: Irimpan I Mathews; Daniel McMullan; Mitchell D Miller; Jaume M Canaves; Marc-André Elsliger; Ross Floyd; Slawomir K Grzechnik; Lukasz Jaroszewski; Heath E Klock; Eric Koesema; John S Kovarik; Andreas Kreusch; Peter Kuhn; Timothy M McPhillips; Andrew T Morse; Kevin Quijano; Christopher L Rife; Robert Schwarzenbacher; Glen Spraggon; Raymond C Stevens; Henry van den Bedem; Dana Weekes; Guenter Wolf; Keith O Hodgson; John Wooley; Ashley M Deacon; Adam Godzik; Scott A Lesley; Ian A Wilson
Crystal structure of 2-keto-3-deoxygluconate kinase (TM0067) from Thermotoga maritima at 2.05 A resolution.
Proteins 2008;70(2):603-8.
2008: Christian H Bell; Ralph Pantophlet; André Schiefner; Lisa A Cavacini; Robyn L Stanfield; Dennis R Burton; Ian A Wilson
Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization.
Journal of molecular biology 2008;375(4):969-78.
2008: Steven M Johnson; Stephen Connelly; Ian A Wilson; Jeffery W Kelly
Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
Journal of medicinal chemistry 2008;51(2):260-70.
2007: Raphael Stoll; Brian M Lee; Erik W Debler; John H Laity; Ian A Wilson; H Jane Dyson; Peter Wright
Structure of the Wilms tumor suppressor protein zinc finger domain bound to DNA.
Journal of molecular biology 2007;372(5):1227-45.
2007: Dennis R Burton; Ian A Wilson
Immunology. Square-dancing antibodies.
Science (New York, N.Y.) 2007;317(5844):1507-8.
2007: Sha Huang; Gail Romanchuk; Katherine A Pattridge; Scott A Lesley; Ian A Wilson; Rowena G Matthews; Martha Ludwig
Reactivation of methionine synthase from Thermotoga maritima (TM0268) requires the downstream gene product TM0269.
Protein science : a publication of the Protein Society 2007;16(8):1588-95.
2007: Erica Ollmann Saphire; Marinieve Montero; Alfredo Menendez; Nienke E van Houten; Melita B Irving; Ralph Pantophlet; Michael B Zwick; Paul W H I Parren; Dennis R Burton; jamie scott; Ian A Wilson
Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies.
Journal of molecular biology 2007;369(3):696-709.
2007: Erik W Debler; Gunnar Kaufmann; Robert N Kirchdoerfer; Jenny M Mee; Kim D Janda; Ian A Wilson
Crystal structures of a quorum-quenching antibody.
Journal of molecular biology 2007;368(5):1392-402.
2007: Lan Xu; Youhoon Chong; Inhwan Hwang; Anthony D'Onofrio; Kristen Amore; G Peter Beardsley; Chenglong Li; Arthur J Olson; Dale L Boger; Ian A Wilson
Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase.
The Journal of biological chemistry 2007;282(17):13033-46.
2007: Josh D Nelson; Florence Brunel; Richard Jensen; Emma T Crooks; Rosa M F Cardoso; Meng Wang; Ann J Hessell; Ian A Wilson; James M Binley; Philip E Dawson; Dennis R Burton; Michael B Zwick
An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10.
Journal of virology 2007;81(8):4033-43.
2007: Mansun Law; Rosa M F Cardoso; Ian A Wilson; Dennis R Burton
Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategy.
Journal of virology 2007;81(8):4272-85.
2007: Dana Weekes; Mitchell D Miller; S Sri Krishna; Daniel McMullan; Timothy M McPhillips; Claire Acosta; Jaume M Canaves; Marc-André Elsliger; Ross Floyd; Slawomir K Grzechnik; Lukasz Jaroszewski; Heath E Klock; Eric Koesema; John S Kovarik; Andreas Kreusch; Andrew T Morse; Kevin Quijano; Glen Spraggon; Henry van den Bedem; Guenter Wolf; Keith O Hodgson; John Wooley; Ashley M Deacon; Adam Godzik; Scott A Lesley; Ian A Wilson
Crystal structure of a transcription regulator (TM1602) from Thermotoga maritima at 2.3 A resolution.
Proteins 2007;67(1):247-52.
2007: Robyn L Stanfield; Helen Dooley; Petra Verdino; Martin F Flajnik; Ian A Wilson
Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding.
Journal of molecular biology 2007;367(2):358-72.
2007: Rosa M F Cardoso; Florence Brunel; Sharon Ferguson; Michael B Zwick; Dennis R Burton; Philip E Dawson; Ian A Wilson
Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.
Journal of molecular biology 2007;365(5):1533-44.
2007: Roger Müller; Erik W Debler; Michael Steinmann; Florian P Seebeck; Ian A Wilson; Donald Hilvert
Bifunctional catalysis of proton transfer at an antibody active site.
Journal of the American Chemical Society 2007;129(3):460-1.
2007: Dirk Zajonc; Ian A Wilson
Architecture of CD1 proteins.
Current topics in microbiology and immunology 2007;314():27-50.
2006: Ziva D Cooper; Diwahar Narasimhan; Roger K Sunahara; Pawel Mierzejewski; Emily Jutkiewicz; Nicholas A Larsen; Ian A Wilson; Donald W Landry; James H Woods
Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase.
Molecular pharmacology 2006;70(6):1885-91.
2006: Feng Tian; Erik W Debler; David P Millar; Ashok A Deniz; Ian A Wilson; Peter G Schultz
The effects of antibodies on stilbene excited-state energetics.
Angewandte Chemie (International ed. in English) 2006;45(46):7763-5.
2006: James Stevens; Ola Blixt; James C Paulson; Ian A Wilson
Glycan microarray technologies: tools to survey host specificity of influenza viruses.
Nature reviews. Microbiology 2006;4(11):857-64.
2006: Dirk Zajonc; Gary D Ainge; Gavin F Painter; Wayne B Severn; Ian A Wilson
Structural characterization of mycobacterial phosphatidylinositol mannoside binding to mouse CD1d.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4577-83.
2006: Robert Schwarzenbacher; Daniel McMullan; S Sri Krishna; Qingping Xu; Mitchell D Miller; Jaume M Canaves; Marc-André Elsliger; Ross Floyd; Slawomir K Grzechnik; Lukasz Jaroszewski; Heath E Klock; Eric Koesema; John S Kovarik; Andreas Kreusch; Peter Kuhn; Timothy M McPhillips; Andrew T Morse; Kevin Quijano; Glen Spraggon; Raymond C Stevens; Henry van den Bedem; Guenter Wolf; Keith O Hodgson; John Wooley; Ashley M Deacon; Adam Godzik; Scott A Lesley; Ian A Wilson
Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2.70 A resolution reveals a new fold.
Proteins 2006;65(1):243-8.
2006: Yuki Kinjo; Emmanuel Tupin; Douglass Wu; Masakazu Fujio; Raquel Garcia-Navarro; Mohammed Rafii-El-Idrissi Benhnia; Dirk Zajonc; Gil Ben-Menachem; Gary D Ainge; Gavin F Painter; Archana Khurana; Kasper Hoebe; Samuel M Behar; Bruce Beutler; Ian A Wilson; Moriya Tsuji; Timothy J Sellati; Chi-Huey Wong; Mitchell Kronenberg
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria.
Nature immunology 2006;7(9):978-86.
2006: Zhengfan Jiang; Philippe Georgel; Chenglong Li; Jungwoo Choe; Karine Crozat; Sophie Rutschmann; Xin Du; Tim Bigby; Suzanne Mudd; Sosathya Sovath; Ian A Wilson; Arthur Olson; Bruce Beutler
Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):10961-6.
2006: Tan-Yun Cheng; Miguel Relloso; Ildiko Van Rhijn; David C Young; Gurdyal S Besra; Volker Briken; Dirk Zajonc; Ian A Wilson; Steven A Porcelli; D Branch Moody
Role of lipid trimming and CD1 groove size in cellular antigen presentation.
The EMBO journal 2006;25(13):2989-99.
2006: Robyn L Stanfield; Miroslaw K Gorny; Susan Zolla-Pazner; Ian A Wilson
Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity.
Journal of virology 2006;80(12):6093-105.
2006: Jessica K DeMartino; Inhwan Hwang; Lan Xu; Ian A Wilson; Dale L Boger
Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase.
Journal of medicinal chemistry 2006;49(10):2998-3002.
2006: Margaret A Johnson; Wolfgang Peti; Torsten Herrmann; Ian A Wilson; Kurt Wüthrich
Solution structure of Asl1650, an acyl carrier protein from Anabaena sp. PCC 7120 with a variant phosphopantetheinylation-site sequence.
Protein science : a publication of the Protein Society 2006;15(5):1030-41.
2006: David A Shore; Luc Teyton; Raymond A Dwek; Pauline M Rudd; Ian A Wilson
Crystal structure of the TCR co-receptor CD8alphaalpha in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolution.
Journal of molecular biology 2006;358(2):347-54.
2006: James Stevens; Ola Blixt; Terrence M Tumpey; Jeffery Taubenberger; James C Paulson; Ian A Wilson
Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus.
Science (New York, N.Y.) 2006;312(5772):404-10.
2006: Robyn L Stanfield; Adam Zemla; Ian A Wilson; Bernhard Rupp
Antibody elbow angles are influenced by their light chain class.
Journal of molecular biology 2006;357(5):1566-74.
2006: Douglass Wu; Dirk Zajonc; Masakazu Fujio; Barbara A Sullivan; Yuki Kinjo; Mitchell Kronenberg; Ian A Wilson; Chi-Huey Wong
Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(11):3972-7.
2006: Xueyong Zhu; Paul Wentworth; Robert A Kyle; Richard A Lerner; Ian A Wilson
Cofactor-containing antibodies: crystal structure of the original yellow antibody.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3581-5.
2006: Deborah Palestrant; Erik W Debler; Patricia A Horton; Kendall A Smith; Ian A Wilson
Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2788-93.
2006: James Stevens; Ola Blixt; Laurel Glaser; Jeffery Taubenberger; Peter Palese; James C Paulson; Ian A Wilson
Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities.
Journal of molecular biology 2006;355(5):1143-55.
2006: Xueyong Zhu; Tobin J Dickerson; Claude J Rogers; Gunnar Kaufmann; Jenny M Mee; Kathleen M. McKenzie; Kim D Janda; Ian A Wilson
Complete reaction cycle of a cocaine catalytic antibody at atomic resolution.
Structure (London, England : 1993) 2006;14(2):205-16.
2006: Florence Brunel; Michael B Zwick; Rosa M F Cardoso; Josh D Nelson; Ian A Wilson; Dennis R Burton; Philip E Dawson
Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody.
Journal of virology 2006;80(4):1680-7.
2005: Dirk Zajonc; Igor Maricic; Douglass Wu; Ramesh C Halder; Keshab Roy; Chi-Huey Wong; Vipin Kumar; Ian A Wilson
Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity.
The Journal of experimental medicine 2005;202(11):1517-26.
2005: Wolfgang Peti; Rebecca Page; Kin Moy; Mark O'Neil-Johnson; Ian A Wilson; Raymond C Stevens; Kurt Wüthrich
Towards miniaturization of a structural genomics pipeline using micro-expression and microcoil NMR.
Journal of structural and functional genomics 2005;6(4):259-67.
2005: Marcius S Almeida; Torsten Herrmann; Wolfgang Peti; Ian A Wilson; Kurt Wüthrich
NMR structure of the conserved hypothetical protein TM0487 from Thermotoga maritima: implications for 216 homologous DUF59 proteins.
Protein science : a publication of the Protein Society 2005;14(11):2880-6.
2005: Dennis R Burton; Robyn L Stanfield; Ian A Wilson
Antibody vs. HIV in a clash of evolutionary titans.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(42):14943-8.
2005: John G Luz; Minmin Yu; Ying Su; Zining Wu; Zhou Zhou; Ren Sun; Ian A Wilson
Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7A.
Journal of molecular biology 2005;352(5):1019-28.
2005: Daniel A Calarese; Hing-Ken Lee; Cheng-Yuan Huang; Michael D Best; Rena D Astronomo; Robyn L Stanfield; Hermann Katinger; Dennis R Burton; Chi-Huey Wong; Ian A Wilson
Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13372-7.
2005: Laurel Glaser; James Stevens; Dmitriy Zamarin; Ian A Wilson; Adolfo García-Sastre; Terrence M Tumpey; Christopher F Basler; Jeffery Taubenberger; Peter Palese
A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity.
Journal of virology 2005;79(17):11533-6.
2005: Dirk Zajonc; Carlos Cantu; Jochen Mattner; Dapeng Zhou; Paul B Savage; Albert Bendelac; Ian A Wilson; Luc Teyton
Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor.
Nature immunology 2005;6(8):810-8.
2005: Jungwoo Choe; Matthew S Kelker; Ian A Wilson
Crystal structure of human toll-like receptor 3 (TLR3) ectodomain.
Science (New York, N.Y.) 2005;309(5734):581-5.
2005: Barbara Giabbai; Stèphane Sidobre; Max Crispin; Yovan Sánchez-Ruiz; Angela Bachi; Mitchell Kronenberg; Ian A Wilson; Massimo Degano
Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):977-84.
2005: Ildiko Van Rhijn; Dirk Zajonc; Ian A Wilson; D Branch Moody
T-cell activation by lipopeptide antigens.
Current opinion in immunology 2005;17(3):222-9.
2005: Heng Cheng; Inhwan Hwang; Youhoon Chong; Ali Tavassoli; Michael E Webb; Yan Zhang; Ian A Wilson; Stephen J Benkovic; Dale L Boger
Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway.
Bioorganic & medicinal chemistry 2005;13(10):3593-9.
2005: Youhoon Chong; Inhwan Hwang; Ali Tavassoli; Yan Zhang; Ian A Wilson; Stephen J Benkovic; Dale L Boger
Synthesis and biological evaluation of alpha- and gamma-carboxamide derivatives of 10-CF3CO-DDACTHF.
Bioorganic & medicinal chemistry 2005;13(10):3587-92.
2005: Heng Cheng; Youhoon Chong; Inhwan Hwang; Ali Tavassoli; Yan Zhang; Ian A Wilson; Stephen J Benkovic; Dale L Boger
Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
Bioorganic & medicinal chemistry 2005;13(10):3577-85.
2005: D Branch Moody; Dirk Zajonc; Ian A Wilson
Anatomy of CD1-lipid antigen complexes.
Nature reviews. Immunology 2005;5(5):387-99.
2005: Yan Zhang; Lei Wang; Peter G Schultz; Ian A Wilson
Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine.
Protein science : a publication of the Protein Society 2005;14(5):1340-9.
2005: R Luke Wiseman; Steven M Johnson; Matthew S Kelker; Ted R Foss; Ian A Wilson; Jeffery W Kelly
Kinetic stabilization of an oligomeric protein by a single ligand binding event.
Journal of the American Chemical Society 2005;127(15):5540-51.
2005: Ted R Foss; Matthew S Kelker; R Luke Wiseman; Ian A Wilson; Jeffery W Kelly
Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis.
Journal of molecular biology 2005;347(4):841-54.
2005: Erik W Debler; Shuichiro Ito; Florian P Seebeck; Andreas Heine; Donald Hilvert; Ian A Wilson
Structural origins of efficient proton abstraction from carbon by a catalytic antibody.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(14):4984-9.
2005: Rebecca Page; Wolfgang Peti; Ian A Wilson; Raymond C Stevens; Kurt Wüthrich
NMR screening and crystal quality of bacterially expressed prokaryotic and eukaryotic proteins in a structural genomics pipeline.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):1901-5.
2005: Dirk Zajonc; Max Crispin; Thomas A Bowden; David C Young; Tan-Yun Cheng; Jingdan Hu; Catherine E Costello; Pauline M Rudd; Raymond A Dwek; Marvin J Miller; Michael B Brenner; D Branch Moody; Ian A Wilson
Molecular mechanism of lipopeptide presentation by CD1a.
Immunity 2005;22(2):209-19.
2005: Rosa M F Cardoso; Michael B Zwick; Robyn L Stanfield; Renate Kunert; James M Binley; Hermann Katinger; Dennis R Burton; Ian A Wilson
Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41.
Immunity 2005;22(2):163-73.
2005: David L Hava; Manfred Brigl; Peter van den Elzen; Dirk Zajonc; Ian A Wilson; Michael B Brenner
CD1 assembly and the formation of CD1-antigen complexes.
Current opinion in immunology 2005;17(1):88-94.
2005: Robyn L Stanfield; Ian A Wilson
Structural studies of human HIV-1 V3 antibodies.
Human antibodies 2005;14(3-4):73-80.
2005: David A Shore; Ian A Wilson; Raymond A Dwek; Pauline M Rudd
Glycosylation and the function of the T cell co-receptor CD8.
Advances in experimental medicine and biology 2005;564():71-84.
2005: Scott A Lesley; Ian A Wilson
Protein production and crystallization at the joint center for structural genomics.
Journal of structural and functional genomics 2005;6(2-3):71-9.
2004: Chenglong Li; Lan Xu; Dennis W Wolan; Ian A Wilson; Arthur J Olson
Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors.
Journal of medicinal chemistry 2004;47(27):6681-90.
2004: Matthew S Kelker; Erik W Debler; Ian A Wilson
Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 A.
Journal of molecular biology 2004;344(5):1175-81.
2004: Ola Blixt; Steven R Head; Tony Mondala; Christopher N Scanlan; Margaret E Huflejt; Richard Alvarez; Marian C. Bryan; Fabio Fazio; Daniel A Calarese; James Stevens; Nahid Razi; David J Stevens; John J Skehel; Irma Van Die; Dennis R Burton; Ian A Wilson; Richard D Cummings; Nicolai Bovin; Chi-Huey Wong; James C Paulson
Printed covalent glycan array for ligand profiling of diverse glycan binding proteins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(49):17033-8.
2004: Jaume M Canaves; Rebecca Page; Ian A Wilson; Raymond C Stevens
Protein biophysical properties that correlate with crystallization success in Thermotoga maritima: maximum clustering strategy for structural genomics.
Journal of molecular biology 2004;344(4):977-91.
2004: Glen Spraggon; Dennis Pantazatos; Heath E Klock; Ian A Wilson; Virgil L Woods; Scott A Lesley
On the use of DXMS to produce more crystallizable proteins: structures of the T. maritima proteins TM0160 and TM1171.
Protein science : a publication of the Protein Society 2004;13(12):3187-99.
2004: Lan Xu; Chenglong Li; Arthur J Olson; Ian A Wilson
Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening.
The Journal of biological chemistry 2004;279(48):50555-65.
2004: Xueyong Zhu; Fujie Tanaka; Yunfeng Hu; Andreas Heine; Roberta Fuller; Guofu Zhong; Arthur J Olson; Richard A Lerner; Carlos F Barbas; Ian A Wilson
The origin of enantioselectivity in aldolase antibodies: crystal structure, site-directed mutagenesis, and computational analysis.
Journal of molecular biology 2004;343(5):1269-80.
2004: Andreas Heine; John G Luz; Chi-Huey Wong; Ian A Wilson
Analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99A resolution.
Journal of molecular biology 2004;343(4):1019-34.
2004: Xiaodong Robert Wang; Jeanne Matteson; Yu An; Bryan D Moyer; Jin-San Yoo; Serguei Bannykh; Ian A Wilson; John R Riordan; William E Balch
COPII-dependent export of cystic fibrosis transmembrane conductance regulator from the ER uses a di-acidic exit code.
The Journal of cell biology 2004;167(1):65-74.
2004: Ralph Pantophlet; Ian A Wilson; Dennis R Burton
Improved design of an antigen with enhanced specificity for the broadly HIV-neutralizing antibody b12.
Protein engineering, design & selection : PEDS 2004;17(10):749-58.
2004: Matthew S Kelker; Ted R Foss; Wolfgang Peti; Luc Teyton; Jeffery W Kelly; Kurt Wüthrich; Ian A Wilson
Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A.
Journal of molecular biology 2004;342(4):1237-48.
2004: Robyn L Stanfield; Helen Dooley; Martin F Flajnik; Ian A Wilson
Crystal structure of a shark single-domain antibody V region in complex with lysozyme.
Science (New York, N.Y.) 2004;305(5691):1770-3.
2004: Marian C. Bryan; Fabio Fazio; Hing-Ken Lee; Cheng-Yuan Huang; Aileen Chang; Michael D Best; Daniel A Calarese; Ola Blixt; James C Paulson; Dennis Burton; Ian A Wilson; Chi-Huey Wong
Covalent display of oligosaccharide arrays in microtiter plates.
Journal of the American Chemical Society 2004;126(28):8640-1.
2004: Jean-Baptiste Reiser; Luc Teyton; Ian A Wilson
Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution.
Journal of molecular biology 2004;340(4):909-17.
2004: Nicholas A Larsen; Paloma de Prada; Shi-Xian Deng; A Mittal; M Braskett; Xueyong Zhu; Ian A Wilson; Donald W Landry
Crystallographic and biochemical analysis of cocaine-degrading antibody 15A10.
Biochemistry 2004;43(25):8067-76.
2004: Max Crispin; Gayle E Ritchie; Alison J Critchley; B Paul Morgan; Ian A Wilson; Raymond A Dwek; Robert B Sim; Pauline M Rudd
Monoglucosylated glycans in the secreted human complement component C3: implications for protein biosynthesis and structure.
FEBS letters 2004;566(1-3):270-4.
2004: Cheom-Gil Cheong; Dennis W Wolan; Samantha E Greasley; Patricia A Horton; G Peter Beardsley; Ian A Wilson
Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates.
The Journal of biological chemistry 2004;279(17):18034-45.
2004: Markus G Rudolph; Christer Wingren; Michael P Crowley; Yueh-hsiu Chien; Ian A Wilson
Combined pseudo-merohedral twinning, non-crystallographic symmetry and pseudo-translation in a monoclinic crystal form of the gammadelta T-cell ligand T10.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 4):656-64.
2004: James Stevens; Adam L Corper; Christopher F Basler; Jeffery Taubenberger; Peter Palese; Ian A Wilson
Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus.
Science (New York, N.Y.) 2004;303(5665):1866-70.
2004: Michael B Zwick; H Kiyomi Komori; Robyn L Stanfield; Sarah Church; Meng Wang; Paul W H I Parren; Renate Kunert; Hermann Katinger; Ian A Wilson; Dennis R Burton
The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5.
Journal of virology 2004;78(6):3155-61.
2004: Dennis R Burton; Ronald C Desrosiers; Robert W Doms; Wayne C Koff; Peter D Kwong; John P Moore; Gary Nabel; Joseph Sodroski; Ian A Wilson; Richard Wyatt
HIV vaccine design and the neutralizing antibody problem.
Nature immunology 2004;5(3):233-6.
2004: Markus G Rudolph; Lucy Q Shen; Stephen A Lamontagne; John G Luz; Joseph R Delaney; Qing Ge; Bryan K Cho; Deborah Palliser; Carol A McKinley; Jianzhu Chen; Ian A Wilson; Herman N Eisen
A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):2994-3002.
2004: Xueyong Zhu; Paul Wentworth; Anita D Wentworth; Albert Eschenmoser; Richard A Lerner; Ian A Wilson
Probing the antibody-catalyzed water-oxidation pathway at atomic resolution.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(8):2247-52.
2004: Hing-Ken Lee; Christopher N Scanlan; Cheng-Yuan Huang; Aileen Y Chang; Daniel A Calarese; Raymond A Dwek; Pauline M Rudd; Dennis R Burton; Ian A Wilson; Chi-Huey Wong
Reactivity-based one-pot synthesis of oligomannoses: defining antigens recognized by 2G12, a broadly neutralizing anti-HIV-1 antibody.
Angewandte Chemie (International ed. in English) 2004;43(8):1000-3.
2004: Dennis W Wolan; Cheom-Gil Cheong; Samantha E Greasley; Ian A Wilson
Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor.
Biochemistry 2004;43(5):1171-83.
2004: Robyn L Stanfield; Miroslaw K Gorny; Constance Williams; Susan Zolla-Pazner; Ian A Wilson
Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D.
Structure (London, England : 1993) 2004;12(2):193-204.
2004: D Branch Moody; David C Young; Tan-Yun Cheng; Jean-Pierre Rosat; Carme Roura-Mir; Peter B O'Connor; Dirk Zajonc; Andrew Walz; Marvin J Miller; Steven B Levery; Ian A Wilson; Catherine E Costello; Michael B Brenner
T cell activation by lipopeptide antigens.
Science (New York, N.Y.) 2004;303(5657):527-31.
2004: Dennis Pantazatos; Jack S Kim; Heath E Klock; Raymond C Stevens; Ian A Wilson; Scott A Lesley; Virgil L Woods
Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(3):751-6.
2003: Robyn L Stanfield; Jayant B Ghiara; Erica Ollmann Saphire; Albert T Profy; Ian A Wilson
Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop.
Virology 2003;315(1):159-73.
2003: Joel Desharnais; Inhwan Hwang; Yan Zhang; Ali Tavassoli; Justin Baboval; Stephen J Benkovic; Ian A Wilson; Dale L Boger
Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
Bioorganic & medicinal chemistry 2003;11(20):4511-21.
2003: Thomas H Marsilje; Michael P Hedrick; Joel Desharnais; Kevin Capps; Ali Tavassoli; Yan Zhang; Ian A Wilson; Stephen J Benkovic; Dale L Boger
10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.
Bioorganic & medicinal chemistry 2003;11(20):4503-9.
2003: Thomas H Marsilje; Michael P Hedrick; Joel Desharnais; Ali Tavassoli; Yan Zhang; Ian A Wilson; Stephen J Benkovic; Dale L Boger
Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
Bioorganic & medicinal chemistry 2003;11(20):4487-501.
2003: Christoph Rader; James M Turner; Andreas Heine; Doron Shabat; Subhash C Sinha; Ian A Wilson; Richard A Lerner; Carlos F Barbas
A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy.
Journal of molecular biology 2003;332(4):889-99.
2003: Dennis W Wolan; Samantha E Greasley; Mark J Wall; Stephen J Benkovic; Ian A Wilson
Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site.
Biochemistry 2003;42(37):10904-14.
2003: Dirk Zajonc; Marc A Elsliger; Luc Teyton; Ian A Wilson
Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A.
Nature immunology 2003;4(8):808-15.
2003: Daniel A Calarese; Christopher N Scanlan; Michael B Zwick; Songpon Deechongkit; Yusuke Mimura; Renate Kunert; Ping Zhu; Mark R Wormald; Robyn L Stanfield; Kenneth H Roux; Jeffery W Kelly; Pauline M Rudd; Raymond A Dwek; Hermann Katinger; Dennis R Burton; Ian A Wilson
Antibody domain exchange is an immunological solution to carbohydrate cluster recognition.
Science (New York, N.Y.) 2003;300(5628):2065-71.
2003: El-Rashdy M Redwan; Nicholas A Larsen; Bin Zhou; Peter Wirsching; Kim D Janda; Ian A Wilson
Expression and characterization of a humanized cocaine-binding antibody.
Biotechnology and bioengineering 2003;82(5):612-8.
2003: Louise Royle; Anja Roos; David Harvey; Mark R Wormald; Daniëlle J van Gijlswijk-Janssen; El-Rashdy M Redwan; Ian A Wilson; Mohamed R Daha; Raymond A Dwek; Pauline M Rudd
Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems.
The Journal of biological chemistry 2003;278(22):20140-53.
2003: Yan Zhang; Joel Desharnais; Thomas H Marsilje; Chenglong Li; Michael P Hedrick; Lata T Gooljarsingh; Ali Tavassoli; Stephen J Benkovic; Arthur J Olson; Dale L Boger; Ian A Wilson
Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.
Biochemistry 2003;42(20):6043-56.
2003: Xueyong Zhu; Andreas Heine; Frédéric Monnat; Kendall N Houk; Kim D Janda; Ian A Wilson
Structural basis for antibody catalysis of a cationic cyclization reaction.
Journal of molecular biology 2003;329(1):69-83.
2003: Ralph Pantophlet; Ian A Wilson; Dennis R Burton
Hyperglycosylated mutants of human immunodeficiency virus (HIV) type 1 monomeric gp120 as novel antigens for HIV vaccine design.
Journal of virology 2003;77(10):5889-901.
2003: Michael B Zwick; Paul W H I Parren; Erica Ollmann Saphire; Sarah Church; Meng Wang; jamie scott; Philip E Dawson; Ian A Wilson; Dennis R Burton
Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120.
Journal of virology 2003;77(10):5863-76.
2003: John Gately Luz; Christian A Hassig; Catherine Pickle; Adam Godzik; Barbara J Meyer; Ian A Wilson
XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators.
Genes & development 2003;17(8):977-90.
2003: Yu An; Ying Shao; Christelle Alory; Jeanne Matteson; Toshiaki Sakisaka; Wei Chen; Richard A Gibbs; Ian A Wilson; William E Balch
Geranylgeranyl switching regulates GDI-Rab GTPase recycling.
Structure (London, England : 1993) 2003;11(3):347-57.
2003: Yuerong Zhu; Alexander Y Rudensky; Adam L Corper; Luc Teyton; Ian A Wilson
Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif.
Journal of molecular biology 2003;326(4):1157-74.
2003: Paul Wentworth; Anita D Wentworth; Xueyong Zhu; Ian A Wilson; Kim D Janda; Albert Eschenmoser; Richard A Lerner
Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1490-3.
2003: Markus G Rudolph; Matthew S Kelker; Thomas R Schneider; Todd O Yeates; Vanessa Oseroff; David K Heidary; Patricia Jennings; Ian A Wilson
Use of multiple anomalous dispersion to phase highly merohedrally twinned crystals of interleukin-1beta.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 2):290-8.
2003: Xueyong Zhu; Nicholas A Larsen; Amrik Basran; Neil C Bruce; Ian A Wilson
Observation of an arsenic adduct in an acetyl esterase crystal structure.
The Journal of biological chemistry 2003;278(3):2008-14.
2003: Grace DeSantis; Junjie Liu; David P Clark; Andreas Heine; Ian A Wilson; Chi-Huey Wong
Structure-based mutagenesis approaches toward expanding the substrate specificity of D-2-deoxyribose-5-phosphate aldolase.
Bioorganic & medicinal chemistry 2003;11(1):43-52.
2003: Christopher N Scanlan; Ralph Pantophlet; Mark R Wormald; Erica Ollmann Saphire; Daniel A Calarese; Robyn L Stanfield; Ian A Wilson; Hermann Katinger; Raymond A Dwek; Dennis R Burton; Pauline M Rudd
The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12.
Advances in experimental medicine and biology 2003;535():205-18.
2003: Erica Ollmann Saphire; Robyn L Stanfield; Max Crispin; Garrett Morris; Michael B Zwick; Ralph Pantophlet; Paul W H I Parren; Pauline M Rudd; Raymond A Dwek; Dennis R Burton; Ian A Wilson
Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design.
Advances in experimental medicine and biology 2003;535():55-66.
2003: Ralph Pantophlet; Erica Ollmann Saphire; Pascal Poignard; Paul W H I Parren; Ian A Wilson; Dennis R Burton
Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120.
Journal of virology 2003;77(1):642-58.
2002: Dennis W Wolan; Samantha E Greasley; G Peter Beardsley; Ian A Wilson
Structural insights into the avian AICAR transformylase mechanism.
Biochemistry 2002;41(52):15505-13.
2002: Markus G Rudolph; James Stevens; Jeffrey A Speir; John Trowsdale; Geoffrey W Butcher; Etienne Joly; Ian A Wilson
Crystal structures of two rat MHC class Ia (RT1-A) molecules that are associated differentially with peptide transporter alleles TAP-A and TAP-B.
Journal of molecular biology 2002;324(5):975-90.
2002: Yan Zhang; Joel Desharnais; Samantha E Greasley; G Peter Beardsley; Dale L Boger; Ian A Wilson
Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.
Biochemistry 2002;41(48):14206-15.
2002: Nicholas A Larsen; Andreas Heine; Paloma de Prada; El-Rashdy Redwan; Todd O Yeates; Donald W Landry; Ian A Wilson
Structure determination of a cocaine hydrolytic antibody from a pseudomerohedrally twinned crystal.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 12):2055-9.
2002: James M Turner; Nicholas A Larsen; Amrik Basran; Carlos F Barbas; Neil C Bruce; Ian A Wilson; Richard A Lerner
Biochemical characterization and structural analysis of a highly proficient cocaine esterase.
Biochemistry 2002;41(41):12297-307.
2002: Scott A Lesley; Peter Kuhn; Adam Godzik; Ashley M Deacon; Irimpan I Mathews; Andreas Kreusch; Glen Spraggon; Heath E Klock; Daniel McMullan; Tanya Shin; Juli Vincent; Alyssa Robb; Linda S Brinen; Mitchell D Miller; Timothy M McPhillips; Mark A Miller; Daniel Scheibe; Jaume M Canaves; Chittibabu Guda; Lukasz Jaroszewski; Thomas L Selby; Marc-André Elsliger; John Wooley; Susan S Taylor; Keith O Hodgson; Ian A Wilson; Peter G Schultz; Raymond C Stevens
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11664-9.
2002: Thomas H Marsilje; Marc A Labroli; Michael P Hedrick; Qing Jin; Joel Desharnais; Stephen J Baker; Lata T Gooljarsingh; Joseph Ramcharan; Ali Tavassoli; Yan Zhang; Ian A Wilson; G Peter Beardsley; Stephen J Benkovic; Dale L Boger
10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.
Bioorganic & medicinal chemistry 2002;10(8):2739-49.
2002: Christopher N Scanlan; Ralph Pantophlet; Mark R Wormald; Erica Ollmann Saphire; Robyn L Stanfield; Ian A Wilson; Hermann Katinger; Raymond A Dwek; Pauline M Rudd; Dennis R Burton
The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.
Journal of virology 2002;76(14):7306-21.
2002: Erica Ollmann Saphire; Robyn L Stanfield; Max Crispin; Paul W H I Parren; Pauline M Rudd; Raymond A Dwek; Dennis R Burton; Ian A Wilson
Contrasting IgG structures reveal extreme asymmetry and flexibility.
Journal of molecular biology 2002;319(1):9-18.
2002: Vasso Apostolopoulos; Minmin Yu; Adam L Corper; Wenjun Li; Ian F C McKenzie; Luc Teyton; Ian A Wilson; Magdalena Plebanski
Crystal structure of a non-canonical high affinity peptide complexed with MHC class I: a novel use of alternative anchors.
Journal of molecular biology 2002;318(5):1307-16.
2002: Vasso Apostolopoulos; Minmin Yu; Adam L Corper; Luc Teyton; Geoffrey A Pietersz; Ian F C McKenzie; Ian A Wilson; Magdalena Plebanski
Crystal structure of a non-canonical low-affinity peptide complexed with MHC class I: a new approach for vaccine design.
Journal of molecular biology 2002;318(5):1293-305.
2002: John G Luz; Mingdong Huang; K Christopher Garcia; Markus G Rudolph; Vasso Apostolopoulos; Luc Teyton; Ian A Wilson
Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions.
The Journal of experimental medicine 2002;195(9):1175-86.
2002: Ethan P Grant; Evan M Beckman; Samuel M Behar; Massimo Degano; Daphney Frederique; Gurdyal S Besra; Ian A Wilson; Steven A Porcelli; Stephen T Furlong; Michael B Brenner
Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):3933-40.
2002: Mingdong Huang; Jacques T Weissman; Chenqian Wang; William E Balch; Ian A Wilson
Protein engineering for crystallization of the GTPase Sar1 that regulates ER vesicle budding.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 4):700-3.
2002: Ian A Wilson
Don C. Wiley.
Nature structural biology 2002;9(3):164-6.
2002: Markus G Rudolph; Ian A Wilson
The specificity of TCR/pMHC interaction.
Current opinion in immunology 2002;14(1):52-65.
2002: Kinya Hotta; Ian A Wilson; Donald Hilvert
Probing ligand recognition in the decarboxylase antibody 21D8: implications for the catalytic mechanism.
Biochemistry 2002;41(3):772-9.
2002: Markus G Rudolph; John G Luz; Ian A Wilson
Structural and thermodynamic correlates of T cell signaling.
Annual review of biophysics and biomolecular structure 2002;31():121-49.
2002: Nicholas A Larsen; James M Turner; James Stevens; Susan J Rosser; Amrik Basran; Richard A Lerner; Neil C Bruce; Ian A Wilson
Crystal structure of a bacterial cocaine esterase.
Nature structural biology 2002;9(1):17-21.
2001: Mingdong Huang; Jacques T Weissman; Sophie BERAUD-DUFOUR; P Luan; C Wang; W Chen; Meir Aridor; Ian A Wilson; William E Balch
Crystal structure of Sar1-GDP at 1.7 A resolution and the role of the NH2 terminus in ER export.
The Journal of cell biology 2001;155(6):937-48.
2001: Nicholas A Larsen; Andreas Heine; L Crane; B F Cravatt; Richard A Lerner; Ian A Wilson
Structural basis for a disfavored elimination reaction in catalytic antibody 1D4.
Journal of molecular biology 2001;314(1):93-102.
2001: Markus G Rudolph; Mingdong Huang; Luc Teyton; Ian A Wilson
Crystal structure of an isolated V(alpha) domain of the 2C T-cell receptor.
Journal of molecular biology 2001;314(1):1-8.
2001: Samantha E Greasley; Thomas H Marsilje; H Cai; S Baker; Stephen J Benkovic; Dale L Boger; Ian A Wilson
Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase.
Biochemistry 2001;40(45):13538-47.
2001: Andreas Heine; G DeSantis; John G Luz; M Mitchell; Chi-Huey Wong; Ian A Wilson
Observation of covalent intermediates in an enzyme mechanism at atomic resolution.
Science (New York, N.Y.) 2001;294(5541):369-74.
2001: Raymond C Stevens; S Yokoyama; Ian A Wilson
Global efforts in structural genomics.
Science (New York, N.Y.) 2001;294(5540):89-92.
2001: Paul Wentworth; Lyn H Jones; Anita D Wentworth; Xueyong Zhu; Nicholas A Larsen; Ian A Wilson; X Xu; W A Goddard ; Kim D Janda; Albert Eschenmoser; Richard A Lerner
Antibody catalysis of the oxidation of water.
Science (New York, N.Y.) 2001;293(5536):1806-11.
2001: Erica Ollmann Saphire; Paul W H I Parren; Ralph Pantophlet; Michael B Zwick; G M Morris; Pauline M Rudd; Raymond A Dwek; Robyn L Stanfield; Dennis R Burton; Ian A Wilson
Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design.
Science (New York, N.Y.) 2001;293(5532):1155-9.
2001: Nicholas A Larsen; Bin Zhou; Andreas Heine; Peter Wirsching; Kim D Janda; Ian A Wilson
Crystal structure of a cocaine-binding antibody.
Journal of molecular biology 2001;311(1):9-15.
2001: Ian A Wilson; Robyn L Stanfield
Unraveling the mysteries of gammadelta T cell recognition.
Nature immunology 2001;2(7):579-81.
2001: Samantha E Greasley; P Horton; Joseph Ramcharan; G Peter Beardsley; Stephen J Benkovic; Ian A Wilson
Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis.
Nature structural biology 2001;8(5):402-6.
2001: Pauline M Rudd; Tim Elliott; Peter Cresswell; Ian A Wilson; Raymond A Dwek
Glycosylation and the immune system.
Science (New York, N.Y.) 2001;291(5512):2370-6.
2001: Markus G Rudolph; Jeffrey A Speir; AB Brunmark; N Mattsson; MR Jackson; PA Peterson; Luc Teyton; Ian A Wilson
The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity.
Immunity 2001;14(3):231-42.
2001: Dennis W Wolan; Luc Teyton; Markus G Rudolph; Brigitte Villmow; S Bauer; D H Busch; Ian A Wilson
Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A.
Nature immunology 2001;2(3):248-54.
2001: Ernest Beutler; Carol West; Jeffrey A Speir; Ian A Wilson; M Worley
The hHFE gene of browsing and grazing rhinoceroses: a possible site of adaptation to a low-iron diet.
Blood cells, molecules & diseases 2001;27(1):342-50.
2001: Jeffrey A Speir; James Stevens; Etienne Joly; Geoffrey W Butcher; Ian A Wilson
Two different, highly exposed, bulged structures for an unusually long peptide bound to rat MHC class I RT1-Aa.
Immunity 2001;14(1):81-92.
2001: Erica Ollmann Saphire; Paul W H I Parren; C F Barbas; Dennis R Burton; Ian A Wilson
Crystallization and preliminary structure determination of an intact human immunoglobulin, b12: an antibody that broadly neutralizes primary isolates of HIV-1.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 1):168-71.
2000: Kinya Hotta; H Lange; Dean J Tantillo; Kendall N Houk; Donald Hilvert; Ian A Wilson
Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8.
Journal of molecular biology 2000;302(5):1213-25.
2000: Thomas Stratmann; Vasso Apostolopoulos; Valérie Mallet-Designe; Adam L Corper; C A Scott; Ian A Wilson; Angray S Kang; Luc Teyton
The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binder.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):3214-25.
2000: V M Reyes; Samantha E Greasley; Enrico STURA; G Peter Beardsley; Ian A Wilson
Crystallization and preliminary crystallographic investigations of avian 5-aminoimidazole-4-carboxamide ribonucleotide transformylase-inosine monophosphate cyclohydrolase expressed in Escherichia coli.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 8):1051-4.
2000: Adam L Corper; Thomas Stratmann; Vasso Apostolopoulos; C A Scott; K Christopher Garcia; Angray S Kang; Ian A Wilson; Luc Teyton
A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes.
Science (New York, N.Y.) 2000;288(5465):505-11.
2000: A Karlstrom; Guofu Zhong; Christoph Rader; Nicholas A Larsen; Andreas Heine; Roberta Fuller; Benjamin List; Fujie Tanaka; Ian A Wilson; Carlos F Barbas; Richard A Lerner
Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):3878-83.
2000: P Luan; A Heine; K Zeng; Bryan D Moyer; S E Greasely; P Kuhn; William E Balch; Ian A Wilson
A new functional domain of guanine nucleotide dissociation inhibitor (alpha-GDI) involved in Rab recycling.
Traffic (Copenhagen, Denmark) 2000;1(3):270-81.
2000: M Degano; K Christopher Garcia; Vasso Apostolopoulos; Markus G Rudolph; Luc Teyton; Ian A Wilson
A functional hot spot for antigen recognition in a superagonist TCR/MHC complex.
Immunity 2000;12(3):251-61.
2000: C Wingren; Michael P Crowley; M Degano; Y Chien; Ian A Wilson
Crystal structure of a gammadelta T cell receptor ligand T22: a truncated MHC-like fold.
Science (New York, N.Y.) 2000;287(5451):310-4.
1999: Samantha E Greasley; M M Yamashita; H Cai; Stephen J Benkovic; Dale L Boger; Ian A Wilson
New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid.
Biochemistry 1999;38(51):16783-93.
1999: J Xu; Q Deng; J Chen; Kendall N Houk; J Bartek; Donald Hilvert; Ian A Wilson
Evolution of shape complementarity and catalytic efficiency from a primordial antibody template.
Science (New York, N.Y.) 1999;286(5448):2345-8.
1999: Ian A Wilson
Perspectives: protein structure. Class-conscious TCR?
Science (New York, N.Y.) 1999;286(5446):1867-8.
1999: D Branch Moody; Gurdyal S Besra; Ian A Wilson; Steven A Porcelli
The molecular basis of CD1-mediated presentation of lipid antigens.
Immunological reviews 1999;172():285-96.
1999: Ian A Wilson; Linda Jolliffe
The structure, organization, activation and plasticity of the erythropoietin receptor.
Current opinion in structural biology 1999;9(6):696-704.
1999: Pauline M Rudd; Mark R Wormald; Robyn L Stanfield; M Huang; N Mattsson; Jeffrey A Speir; J A DiGennaro; Jacquelyn S Fetrow; Raymond A Dwek; Ian A Wilson
Roles for glycosylation of cell surface receptors involved in cellular immune recognition.
Journal of molecular biology 1999;293(2):351-66.
1999: Karl Gruber; Bin Zhou; Kendall N Houk; Richard A Lerner; C G Shevlin; Ian A Wilson
Structural basis for antibody catalysis of a disfavored ring closure reaction.
Biochemistry 1999;38(22):7062-74.
1999: Steven A Middleton; FP Barbone; Dana L Johnson; Robin Thurmond; Y You; FJ McMahon; R Jin; O Livnah; Jennifer Tullai; Francis X Farrell; Mark A Goldsmith; Ian A Wilson; Linda Jolliffe
Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide.
The Journal of biological chemistry 1999;274(20):14163-9.
1999: O Livnah; Enrico STURA; Steven A Middleton; Dana L Johnson; Linda Jolliffe; Ian A Wilson
Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation.
Science (New York, N.Y.) 1999;283(5404):987-90.
1999: Ethan P Grant; M Degano; Jean-Pierre Rosat; Steffen Stenger; Robert L Modlin; Ian A Wilson; Steven A Porcelli; Michael B Brenner
Molecular recognition of lipid antigens by T cell receptors.
The Journal of experimental medicine 1999;189(1):195-205.
1999: K Christopher Garcia; M Degano; Jeffrey A Speir; Ian A Wilson
Emerging principles for T cell receptor recognition of antigen in cellular immunity.
Reviews in immunogenetics 1999;1(1):75-90.
1999: K Christopher Garcia; Luc Teyton; Ian A Wilson
Structural basis of T cell recognition.
Annual review of immunology 1999;17():369-97.
1999: Jeffrey A Speir; U M Abdel-Motal; Mikael Jondal; Ian A Wilson
Crystal structure of an MHC class I presented glycopeptide that generates carbohydrate-specific CTL.
Immunity 1999;10(1):51-61.
1998: O Livnah; Dana L Johnson; Enrico STURA; Francis X Farrell; FP Barbone; Y You; Kathleen D Liu; Mark A Goldsmith; W He; Christopher D Krause; Sidney Pestka; Linda Jolliffe; Ian A Wilson
An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation.
Nature structural biology 1998;5(11):993-1004.
1998: Y Su; M M Yamashita; Samantha E Greasley; Craig A Mullen; JH Shim; Patricia Jennings; Stephen J Benkovic; Ian A Wilson
A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A.
Journal of molecular biology 1998;281(3):485-99.
1998: Jeffrey A Speir; K Christopher Garcia; AB Brunmark; M Degano; PA Peterson; Luc Teyton; Ian A Wilson
Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes.
Immunity 1998;8(5):553-62.
1998: T C Manning; C J Schlueter; T C Brodnicki; EA Parke; Jeffrey A Speir; K Christopher Garcia; Luc Teyton; Ian A Wilson; David M Kranz
Alanine scanning mutagenesis of an alphabeta T cell receptor: mapping the energy of antigen recognition.
Immunity 1998;8(4):413-25.
1998: Andreas Heine; Enrico STURA; Jari Yli-Kauhaluoma; Changshou Gao; Q Deng; B R Beno; Kendall N Houk; Kim D Janda; Ian A Wilson
An antibody exo Diels-Alderase inhibitor complex at 1.95 angstrom resolution.
Science (New York, N.Y.) 1998;279(5358):1934-40.
1998: Dana L Johnson; Francis X Farrell; FP Barbone; FJ McMahon; Jennifer Tullai; K Hoey; O Livnah; NC Wrighton; Steven A Middleton; DA Loughney; Enrico STURA; William J Dower; LS Mulcahy; Ian A Wilson; Linda Jolliffe
Identification of a 13 amino acid peptide mimetic of erythropoietin and description of amino acids critical for the mimetic activity of EMP1.
Biochemistry 1998;37(11):3699-710.
1998: CA Scott; PA Peterson; Luc Teyton; Ian A Wilson
Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues.
Immunity 1998;8(3):319-29.
1998: K Christopher Garcia; M Degano; Larry R Pease; Mingdong Huang; PA Peterson; Luc Teyton; Ian A Wilson
Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen.
Science (New York, N.Y.) 1998;279(5354):1166-72.
1998: Mingdong Huang; R Syed; Enrico STURA; M J Stone; R S Stefanko; Wolfram Ruf; Thomas S Edgington; Ian A Wilson
The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex.
Journal of molecular biology 1998;275(5):873-94.
1998: Ian A Wilson; P J Bjorkman
Unusual MHC-like molecules: CD1, Fc receptor, the hemochromatosis gene product, and viral homologs.
Current opinion in immunology 1998;10(1):67-73.
1998: CA Scott; K Christopher Garcia; Enrico STURA; PA Peterson; Ian A Wilson; Luc Teyton
Engineering protein for X-ray crystallography: the murine Major Histocompatibility Complex class II molecule I-Ad.
Protein science : a publication of the Protein Society 1998;7(2):413-8.
1997: Carlos F Barbas; Andreas Heine; Guofu Zhong; T Hoffmann; S Gramatikova; R Björnestedt; Benjamin List; J Anderson; Enrico STURA; Ian A Wilson; Richard A Lerner
Immune versus natural selection: antibody aldolases with enzymic rates but broader scope.
Science (New York, N.Y.) 1997;278(5346):2085-92.
1997: K Christopher Garcia; Michelle Tallquist; Larry R Pease; AB Brunmark; CA Scott; M Degano; Enrico STURA; PA Peterson; Ian A Wilson; Luc Teyton
Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13838-43.
1997: Ian A Wilson; K Christopher Garcia
T-cell receptor structure and TCR complexes.
Current opinion in structural biology 1997;7(6):839-48.
1997: Z Zeng; A. Raúl castaño; B W Segelke; Enrico STURA; PA Peterson; Ian A Wilson
Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove.
Science (New York, N.Y.) 1997;277(5324):339-45.
1997: Mingyue He; Mohamed M Gani; O Livnah; Enrico STURA; Dennis Beale; J Coley; Ian A Wilson; Michael J Taussig
Sequence, specificity and crystallization of an oestrone-3-glucuronide antibody (3910).
Immunology 1997;90(4):632-9.
1997: Jayant B Ghiara; D C Ferguson; Arnold C Satterthwait; H Jane Dyson; Ian A Wilson
Structure-based design of a constrained peptide mimic of the HIV-1 V3 loop neutralization site.
Journal of molecular biology 1997;266(1):31-9.
1996: K Christopher Garcia; C A Scott; AB Brunmark; F R Carbone; PA Peterson; Ian A Wilson; Luc Teyton
CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes.
Nature 1996;384(6609):577-81.
1996: S K Wu; K Zeng; Ian A Wilson; William E Balch
Structural insights into the function of the Rab GDI superfamily.
Trends in biochemical sciences 1996;21(12):472-6.
1996: K Christopher Garcia; M Degano; R L Stanfield; AB Brunmark; MR Jackson; PA Peterson; Luc Teyton; Ian A Wilson
An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex.
Science (New York, N.Y.) 1996;274(5285):209-19.
1996: O Livnah; Enrico STURA; Dana L Johnson; Steven A Middleton; LS Mulcahy; N C Wrighton; William J Dower; Linda Jolliffe; Ian A Wilson
Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A.
Science (New York, N.Y.) 1996;273(5274):464-71.
1996: Ian A Wilson
Another twist to MHC-peptide recognition.
Science (New York, N.Y.) 1996;272(5264):973-4.
1996: I Schalk; K Zeng; S K Wu; Enrico STURA; Jeanne Matteson; M Huang; A Tandon; Ian A Wilson; William E Balch
Structure and mutational analysis of Rab GDP-dissociation inhibitor.
Nature 1996;381(6577):42-8.
1996: C A Scott; K Christopher Garcia; F R Carbone; Ian A Wilson; Luc Teyton
Role of chain pairing for the production of functional soluble IA major histocompatibility complex class II molecules.
The Journal of experimental medicine 1996;183(5):2087-95.
1995: Hanna Lewicki; Antoinette Tishon; Persephone Borrow; Claire F Evans; Jean Edouard Gairin; Klaus M Hahn; David Jewell; Ian A Wilson; Michael B A Oldstone
CTL escape viral variants. I. Generation and molecular characterization.
Virology 1995;210(1):29-40.
1995: C Klein; P Chen; J H Arevalo; Enrico STURA; A Marolewski; MS Warren; Stephen J Benkovic; Ian A Wilson
Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution.
Journal of molecular biology 1995;249(1):153-75.
1995: Enrico STURA; S Ghosh; E Garcia-Junceda; L Chen; Chi-Huey Wong; Ian A Wilson
Crystallization and preliminary crystallographic data for class I deoxyribose-5-phosphate aldolase from Escherichia coli: an application of reverse screening.
Proteins 1995;22(1):67-72.
1995: daved fremont; Enrico STURA; M Matsumura; PA Peterson; Ian A Wilson
Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2479-83.
1995: R L Stanfield; Ian A Wilson
Protein-peptide interactions.
Current opinion in structural biology 1995;5(1):103-13.
1994: I J Schalk; Enrico STURA; Jeanne Matteson; Ian A Wilson; William E Balch
Crystallization and preliminary crystallographic data for Rab guanine nucleotide dissociation inhibitor (RabGDI) from bovine brain.
Journal of molecular biology 1994;244(4):469-73.
1994: Ian A Wilson; R L Stanfield
Antibody-antigen interactions: new structures and new conformational changes.
Current opinion in structural biology 1994;4(6):857-67.
1994: J H Arevalo; C A Hassig; Enrico STURA; M J Sims; Michael J Taussig; Ian A Wilson
Structural analysis of antibody specificity. Detailed comparison of five Fab'-steroid complexes.
Journal of molecular biology 1994;241(5):663-90.
1994: M E Churchill; Enrico STURA; Clemencia Pinilla; J R Appel; R A Houghten; Dwight H Kono; R S Balderas; G G Fieser; U Schulze-Gahmen; Ian A Wilson
Crystal structure of a peptide complex of anti-influenza peptide antibody Fab 26/9. Comparison of two different antibodies bound to the same peptide antigen.
Journal of molecular biology 1994;241(4):534-56.
1994: Enrico STURA; A C Satterthwait; J C Calvo; D C Kaslow; Ian A Wilson
Reverse screening.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 4):448-55.
1994: R L Stanfield; Ian A Wilson
Antigen-induced conformational changes in antibodies: a problem for structural prediction and design.
Trends in biotechnology 1994;12(7):275-9.
1994: Ian A Wilson
Covalently linked ligand stabilizes expression of heterodimeric receptor.
Structure (London, England : 1993) 1994;2(6):561-2.
1994: Ian A Wilson; R L Stanfield; David Jewell; J B Ghiara; daved fremont; Enrico STURA
Immune recognition of viral antigens.
Infectious agents and disease 1994;3(2-3):155-62.
1994: J B Ghiara; Enrico STURA; R L Stanfield; A T Profy; Ian A Wilson
Crystal structure of the principal neutralization site of HIV-1.
Science (New York, N.Y.) 1994;264(5155):82-5.
1994: M R Haynes; Enrico STURA; Donald Hilvert; Ian A Wilson
Routes to catalysis: structure of a catalytic antibody and comparison with its natural counterpart.
Science (New York, N.Y.) 1994;263(5147):646-52.
1994: M R Haynes; Enrico STURA; Donald Hilvert; Ian A Wilson
Crystallization and preliminary structural studies of a chorismate mutase catalytic antibody complexed with a transition state analog.
Proteins 1994;18(2):198-200.
1994: M Gani; J Coley; J Piron; A S Humphreys; J Arevalo; Ian A Wilson; Michael J Taussig
Monoclonal antibodies against progesterone: effect of steroid-carrier coupling position on antibody specificity.
The Journal of steroid biochemistry and molecular biology 1994;48(2-3):277-82.
1994: Ian A Wilson; J B Ghiara; R L Stanfield
Structure of anti-peptide antibody complexes.
Research in immunology 1994;145(1):73-8.
1993: U Schulze-Gahmen; J M Rini; Ian A Wilson
Detailed analysis of the free and bound conformations of an antibody. X-ray structures of Fab 17/9 and three different Fab-peptide complexes.
Journal of molecular biology 1993;234(4):1098-118.
1993: J H Arevalo; Michael J Taussig; Ian A Wilson
Molecular basis of crossreactivity and the limits of antibody-antigen complementarity.
Nature 1993;365(6449):859-63.
1993: R L Stanfield; M Takimoto-Kamimura; J M Rini; A T Profy; Ian A Wilson
Major antigen-induced domain rearrangements in an antibody.
Structure (London, England : 1993) 1993;1(2):83-93.
1993: J M Rini; R L Stanfield; Enrico STURA; P A Salinas; A T Profy; Ian A Wilson
Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):6325-9.
1993: J H Arevalo; Enrico STURA; Michael J Taussig; Ian A Wilson
Three-dimensional structure of an anti-steroid Fab' and progesterone-Fab' complex.
Journal of molecular biology 1993;231(1):103-18.
1993: Ian A Wilson; daved fremont
Structural analysis of MHC class I molecules with bound peptide antigens.
Seminars in immunology 1993;5(2):75-80.
1992: Enrico STURA; M Matsumura; daved fremont; Y Saito; PA Peterson; Ian A Wilson
Crystallization of murine major histocompatibility complex class I H-2Kb with single peptides.
Journal of molecular biology 1992;228(3):975-82.
1992: Enrico STURA; R L Stanfield; G G Fieser; S Silver; M Roguska; L M Hincapie; H K Simmerman; A T Profy; Ian A Wilson
Crystallization, sequence, and preliminary crystallographic data for an antipeptide Fab 50.1 and peptide complexes with the principal neutralizing determinant of HIV-1 gp120.
Proteins 1992;14(4):499-508.
1992: P Chen; U Schulze-Gahmen; Enrico STURA; James Inglese; D L Johnson; A Marolewski; Stephen J Benkovic; Ian A Wilson
Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution. A target enzyme for chemotherapy.
Journal of molecular biology 1992;227(1):283-92.
1992: M Matsumura; daved fremont; PA Peterson; Ian A Wilson
Emerging principles for the recognition of peptide antigens by MHC class I molecules.
Science (New York, N.Y.) 1992;257(5072):927-34.
1992: daved fremont; M Matsumura; Enrico STURA; PA Peterson; Ian A Wilson
Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb.
Science (New York, N.Y.) 1992;257(5072):919-27.
1992: J M Rini; U Schulze-Gahmen; Ian A Wilson
Structural evidence for induced fit as a mechanism for antibody-antigen recognition.
Science (New York, N.Y.) 1992;255(5047):959-65.
1992: Enrico STURA; P Chen; C M Wilmot; J H Arevalo; Ian A Wilson
Crystallization studies of glycosylated and unglycosylated human recombinant interleukin-2.
Proteins 1992;12(1):24-30.
1991: Ian A Wilson; R L Stanfield; J M Rini; J H Arevalo; U Schulze-Gahmen; daved fremont; Enrico STURA
Structural aspects of antibodies and antibody-antigen complexes.
Ciba Foundation symposium 1991;159():13-28; discussion 28-39.
1991: Ian A Wilson; J M Rini; daved fremont; G G Fieser; Enrico STURA
X-ray crystallographic analysis of free and antigen-complexed Fab fragments to investigate structural basis of immune recognition.
Methods in enzymology 1991;203():153-76.
1990: R L Stanfield; T M Fieser; Richard A Lerner; Ian A Wilson
Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A.
Science (New York, N.Y.) 1990;248(4956):712-9.
1990: Ian A Wilson; N J Cox
Structural basis of immune recognition of influenza virus hemagglutinin.
Annual review of immunology 1990;8():737-71.
1989: Enrico STURA; R L Stanfield; T M Fieser; R S Balderas; L R Smith; Richard A Lerner; Ian A Wilson
Preliminary crystallographic data and primary sequence for anti-peptide Fab' B13I2 and its complex with the C-helix peptide from myohemerythrin.
The Journal of biological chemistry 1989;264(26):15721-5.
1989: G Lambert; Enrico STURA; Ian A Wilson
Crystallization and preliminary X-ray diffraction studies of a complex between interleukin-2 and a soluble form of the p55 component of the high affinity interleukin-2 receptor.
The Journal of biological chemistry 1989;264(21):12730-6.
1989: Enrico STURA; D L Johnson; James Inglese; J M Smith; Stephen J Benkovic; Ian A Wilson
Preliminary crystallographic investigations of glycinamide ribonucleotide transformylase.
The Journal of biological chemistry 1989;264(16):9703-6.
1988: U Schulze-Gahmen; J M Rini; J Arevalo; Enrico STURA; J H Kenten; Ian A Wilson
Preliminary crystallographic data, primary sequence, and binding data for an anti-peptide Fab and its complex with a synthetic peptide from influenza virus hemagglutinin.
The Journal of biological chemistry 1988;263(32):17100-5.
1987: Enrico STURA; J H Arevalo; A Feinstein; R B Heap; Michael J Taussig; Ian A Wilson
Analysis of an anti-progesterone antibody: variable crystal morphology of the Fab' and steroid-Fab' complexes.
Immunology 1987;62(4):511-21.