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Ian Wilson
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81
Nicholson, Jeremy
53
Lindon, John
16
Holmes, Elaine
14
Lenz, Eva
14
Plumb, Robert
11
Scarfe, Graeme
11
Castro-Perez, Jose
9
Abou-Shakra, Fadi
8
Lenz, Eva
8
Troke, Jeff
8
Nicholls, Andrew
7
Wright, B
7
Major, Hilary
7
Shockcor, John
7
Johnson, Kelly
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All Publications
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2009: Berry Neil G; Iddon Lisa; Iqbal Mazhar; Meng Xiaoli; Jayapal Prabha; Johnson Caroline H; Nicholson Jeremy K; Lindon John C; Harding John R; Wilson Ian D; Stachulski Andrew V
Synthesis, transacylation kinetics and computational chemistry of a set of arylacetic acid 1beta-O-acyl glucuronides.
Organic & biomolecular chemistry 2009;7(12):2525-33.
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2009: Waldram Alison; Holmes Elaine; Wang Yulan; Rantalainen Mattias; Wilson Ian D; Tuohy Kieran M; McCartney Anne L; Gibson Glenn R; Nicholson Jeremy K
Top-down systems biology modeling of host metabotype-microbiome associations in obese rodents.
Journal of proteome research 2009;8(5):2361-75.
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2009: Swann Jonathan; Wang Yulan; Abecia Leticia; Costabile Adele; Tuohy Kieran; Gibson Glenn; Roberts David; Sidaway James; Jones Huw; Wilson Ian D; Nicholson Jeremy; Holmes Elaine
Gut microbiome modulates the toxicity of hydrazine: a metabonomic study.
Molecular bioSystems 2009;5(4):351-5.
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2009: Backshall Alexandra; Alferez Denis; Teichert Friederike; Wilson Ian D; Wilkinson Robert W; Goodlad Robert A; Keun Hector C
Detection of metabolic alterations in non-tumor gastrointestinal tissue of the Apc(Min/+) mouse by (1)H MAS NMR spectroscopy.
Journal of proteome research 2009;8(3):1423-30.
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2008: Holmes Elaine; Wilson Ian D; Nicholson Jeremy K
Metabolic phenotyping in health and disease.
Cell 2008;134(5):714-7.
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2008: Crockford Derek J; Maher Anthony D; Ahmadi Kourosh R; Barrett Amy; Plumb Robert S; Wilson Ian D; Nicholson Jeremy K
1H NMR and UPLC-MS(E) statistical heterospectroscopy: characterization of drug metabolites (xenometabolome) in epidemiological studies.
Analytical chemistry 2008;80(18):6835-44.
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2008: Yap Ivan K S; Li Jia V; Saric Jasmina; Martin Francois-Pierre; Davies Huw; Wang Yulan; Wilson Ian D; Nicholson Jeremy K; Utzinger Jürg; Marchesi Julian R; Holmes Elaine
Metabonomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse.
Journal of proteome research 2008;7(9):3718-28.
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2008: Athersuch T J; Sison R L; Kenyon A S J; Clarkson-Jones J A; Wilson I D
Evaluation of the use of UPLC-TOFMS with simultaneous [14C]-radioflow detection for drug metabolite profiling: application to propranolol metabolites in rat urine.
Journal of pharmaceutical and biomedical analysis 2008;48(1):151-7.
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2008: Graham Emma E; Walsh Rachel J; Hirst Charlotte M; Maggs James L; Martin Scott; Wild Martin J; Wilson Ian D; Harding John R; Kenna J Gerald; Peter Raimund M; Williams Dominic P; Park B Kevin
Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore.
The Journal of pharmacology and experimental therapeutics 2008;326(2):657-71.
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2008: Johnson Caroline H; Athersuch Toby J; Wilson Ian D; Iddon Lisa; Meng Xiaoli; Stachulski Andrew V; Lindon John C; Nicholson Jeremy K
Kinetic and J-resolved statistical total correlation NMR spectroscopy approaches to structural information recovery in complex reacting mixtures: application to acyl glucuronide intramolecular transacylation reactions.
Analytical chemistry 2008;80(13):4886-95.
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2008: Teichert Friederike; Verschoyle Richard D; Greaves Peter; Edwards Richard E; Teahan Orla; Jones Donald J L; Wilson Ian D; Farmer Peter B; Steward William P; Gant Timothy W; Gescher Andreas J; Keun Hector C
Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism.
The Prostate 2008;68(10):1035-47.
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2008: Gika Helen G; Theodoridis Georgios A; Wilson Ian D
Hydrophilic interaction and reversed-phase ultra-performance liquid chromatography TOF-MS for metabonomic analysis of Zucker rat urine.
Journal of separation science 2008;31(9):1598-608.
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2008: Keun Hector C; Athersuch Toby J; Beckonert Olaf; Wang Yulan; Saric Jasmina; Shockcor John P; Lindon John C; Wilson Ian D; Holmes Elaine; Nicholson Jeremy K
Heteronuclear 19F-1H statistical total correlation spectroscopy as a tool in drug metabolism: study of flucloxacillin biotransformation.
Analytical chemistry 2008;80(4):1073-9.
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2007: Duckett C J; Wilson I D; Douce D S; Walker H J; Abou-Shakra F R; Lindon J C; Nicholson J K
Metabolism of 2-fluoro-4-iodoaniline in earthworm Eisenia veneta using (19)F-NMR spectroscopy, HPLC-MS, and HPLC-ICPMS ((127)I).
Xenobiotica; the fate of foreign compounds in biological systems 2007;37(12):1378-93.
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2007: Johnson Caroline H; Wilson Ian D; Harding John R; Stachulski Andrew V; Iddon Lisa; Nicholson Jeremy K; Lindon John C
NMR spectroscopic studies on the in vitro acyl glucuronide migration kinetics of Ibuprofen ((+/-)-(R,S)-2-(4-isobutylphenyl) propanoic acid), its metabolites, and analogues.
Analytical chemistry 2007;79(22):8720-7.
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2007: Lenz E M; Williams R E; Sidaway J; Smith B W; Plumb R S; Johnson K A; Rainville P; Shockcor J; Stumpf C L; Granger J H; Wilson I D
The application of microbore UPLC/oa-TOF-MS and 1H NMR spectroscopy to the metabonomic analysis of rat urine following the intravenous administration of pravastatin.
Journal of pharmaceutical and biomedical analysis 2007;44(4):845-52.
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2007: Holmes Elaine; Loo Ruey Leng; Cloarec Olivier; Coen Muireann; Tang Huiru; Maibaum Elaine; Bruce Stephen; Chan Queenie; Elliott Paul; Stamler Jeremiah; Wilson Ian D; Lindon John C; Nicholson Jeremy K
Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy.
Analytical chemistry 2007;79(7):2629-40.
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2007: Lenz Eva Maria; Wilson Ian D
Analytical strategies in metabonomics.
Journal of proteome research 2007;6(2):443-58.
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2007: Athersuch T J; Duckett C J; Castro-Perez J; Rodgers C; Nicholson J K; Wilson I D
Metabolism of [14C]-5-chloro-1,3-benzodioxol-4-amine in male Wistar-derived rats following intraperitoneal administration.
Xenobiotica; the fate of foreign compounds in biological systems 2007;37(1):44-58.
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2007: Plumb Robert S; Rainville Paul D; Potts Warren B; Castro-Perez Jose M; Johnson Kelly A; Wilson Ian D
High-temperature ultra-performance liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry applied to ibuprofen metabolites in human urine.
Rapid communications in mass spectrometry : RCM 2007;21(24):4079-85.
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2007: Granger Jennifer H; Williams Rebecca; Lenz Eva M; Plumb Robert S; Stumpf Chris L; Wilson Ian D
A metabonomic study of strain- and age-related differences in the Zucker rat.
Rapid communications in mass spectrometry : RCM 2007;21(13):2039-45.
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2006: Stachulski Andrew V; Harding John R; Lindon John C; Maggs James L; Park B Kevin; Wilson Ian D
Acyl glucuronides: biological activity, chemical reactivity, and chemical synthesis.
Journal of medicinal chemistry 2006;49(24):6931-45.
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2006: Plumb Robert S; Rainville Paul; Smith Brian W; Johnson Kelly A; Castro-Perez Jose; Wilson Ian D; Nicholson Jeremy K
Generation of ultrahigh peak capacity LC separations via elevated temperatures and high linear mobile-phase velocities.
Analytical chemistry 2006;78(20):7278-83.
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2006: Rantalainen Mattias; Cloarec Olivier; Beckonert Olaf; Wilson I D; Jackson David; Tonge Robert; Rowlinson Rachel; Rayner Steve; Nickson Janice; Wilkinson Robert W; Mills Jonathan D; Trygg Johan; Nicholson Jeremy K; Holmes Elaine
Statistically integrated metabonomic-proteomic studies on a human prostate cancer xenograft model in mice.
Journal of proteome research 2006;5(10):2642-55.
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2006: Sangster Timothy; Major Hilary; Plumb Robert; Wilson Amy J; Wilson Ian D
A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis.
The Analyst 2006;131(10):1075-8.
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2006: Nicholls A W; Wilson I D; Godejohann M; Nicholson J K; Shockcor J P
Identification of phenacetin metabolites in human urine after administration of phenacetin-C2H3: measurement of futile metabolic deacetylation via HPLC/MS-SPE-NMR and HPLC-ToF MS.
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(7):615-29.
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2006: Jackson David; Rowlinson Rachel A; Eaton Cassie K; Nickson Janice A; Wilson Ian D; Mills Jonathan D; Wilkinson Robert W; Tonge Robert P
Prostatic tissue protein alterations due to delayed time to freezing.
Proteomics 2006;6(13):3901-8.
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2006: Vanderhoeven Stephen J; Lindon John C; Troke Jeff; Nicholson Jeremy K; Wilson Ian D
NMR spectroscopic studies of the transacylation reactivity of ibuprofen 1-beta-O-acyl glucuronide.
Journal of pharmaceutical and biomedical analysis 2006;41(3):1002-6.
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2006: Williams R E; Lenz E M; Rantalainen M; Wilson I D
The comparative metabonomics of age-related changes in the urinary composition of male Wistar-derived and Zucker (fa/fa) obese rats.
Molecular bioSystems 2006;2(3-4):193-202.
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2006: Williams R; Lenz E M; Wilson A J; Granger J; Wilson I D; Major H; Stumpf C; Plumb R
A multi-analytical platform approach to the metabonomic analysis of plasma from normal and Zucker (fa/fa) obese rats.
Molecular bioSystems 2006;2(3-4):174-83.
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2006: Oudhoff Kathalijne A; Sangster Timothy; Thomas Elizabeth; Wilson Ian D
Application of microbore HPLC in combination with tandem MS for the quantification of rosuvastatin in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2006;832(2):191-6.
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2006: Gavaghan McKee Claire L; Wilson Ian D; Nicholson Jeremy K
Metabolic phenotyping of nude and normal (Alpk:ApfCD, C57BL10J) mice.
Journal of proteome research 2006;5(2):378-84.
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2006: Duckett C J; Lindon J C; Walker H; Abou-Shakra F; Wilson I D; Nicholson J K
Metabolism of 3-chloro-4-fluoroaniline in rat using [14C]-radiolabelling, 19F-NMR spectroscopy, HPLC-MS/MS, HPLC-ICPMS and HPLC-NMR.
Xenobiotica; the fate of foreign compounds in biological systems 2006;36(1):59-77.
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2006: Plumb Robert S; Johnson Kelly A; Rainville Paul; Shockcor John P; Williams Rebecca; Granger Jennifer H; Wilson Ian D
The detection of phenotypic differences in the metabolic plasma profile of three strains of Zucker rats at 20 weeks of age using ultra-performance liquid chromatography/orthogonal acceleration time-of-flight mass spectrometry.
Rapid communications in mass spectrometry : RCM 2006;20(19):2800-6.
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2006: Plumb Robert S; Johnson Kelly A; Rainville Paul; Smith Brian W; Wilson Ian D; Castro-Perez Jose M; Nicholson Jeremy K
UPLC/MS(E); a new approach for generating molecular fragment information for biomarker structure elucidation.
Rapid communications in mass spectrometry : RCM 2006;20(13):1989-94.
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2005: Williams R E; Lenz E M; Lowden J S; Rantalainen M; Wilson I D
The metabonomics of aging and development in the rat: an investigation into the effect of age on the profile of endogenous metabolites in the urine of male rats using 1H NMR and HPLC-TOF MS.
Molecular bioSystems 2005;1(2):166-75.
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2005: Skordi E; Wilson I D; Lindon J C; Nicholson J K
Kinetic studies on the intramolecular acyl migration of beta-1-O-acyl glucuronides: application to the glucuronides of (R)- and (S)-ketoprofen, (R)- and (S)-hydroxy-ketoprofen metabolites, and tolmetin by 1H-NMR spectroscopy.
Xenobiotica; the fate of foreign compounds in biological systems 2005;35(7):715-25.
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2005: Williams Rebecca E; Lenz Eva M; Evans Julie A; Wilson Ian D; Granger Jennifer H; Plumb Robert S; Stumpf Chris L
A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats.
Journal of pharmaceutical and biomedical analysis 2005;38(3):465-71.
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2005: Plumb Robert S; Granger Jennifer H; Stumpf Chris L; Johnson Kelly A; Smith Brian W; Gaulitz Scott; Wilson Ian D; Castro-Perez Jose
A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: application to age, gender and diurnal variation in normal/Zucker obese rats and black, white and nude mice.
The Analyst 2005;130(6):844-9.
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2005: Nicholson Jeremy K; Holmes Elaine; Wilson Ian D
Gut microorganisms, mammalian metabolism and personalized health care.
Nature reviews. Microbiology 2005;3(5):431-8.
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2005: Lenz E M; Bright J; Knight R; Westwood F R; Davies D; Major H; Wilson I D
Metabonomics with 1H-NMR spectroscopy and liquid chromatography-mass spectrometry applied to the investigation of metabolic changes caused by gentamicin-induced nephrotoxicity in the rat.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2005;10(2-3):173-87.
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2005: Wilson Ian D; Nicholson Jeremy K; Castro-Perez Jose; Granger Jennifer H; Johnson Kelly A; Smith Brian W; Plumb Robert S
High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies.
Journal of proteome research 2005;4(2):591-8.
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2005: Wilson Ian D; Plumb Robert; Granger Jennifer; Major Hilary; Williams Rebecca; Lenz Eva M
HPLC-MS-based methods for the study of metabonomics.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;817(1):67-76.
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2005: Williams R E; Major H; Lock E A; Lenz E M; Wilson I D
D-Serine-induced nephrotoxicity: a HPLC-TOF/MS-based metabonomics approach.
Toxicology 2005;207(2):179-90.
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2005: Jensen Berit Packert; Smith Christopher J; Bailey Christopher J; Rodgers Colin; Wilson Ian D; Nicholson Jeremy K
Investigation of the metabolic fate of 2-, 3- and 4-bromobenzoic acids in bile-duct-cannulated rats by inductively coupled plasma mass spectrometry and high-performance liquid chromatography/inductively coupled plasma mass spectrometry/electrospray mass spectrometry.
Rapid communications in mass spectrometry : RCM 2005;19(4):519-24.
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2004: Skordi E; Wilson I D; Lindon J C; Nicholson J K
Characterization and quantification of metabolites of racemic ketoprofen excreted in urine following oral administration to man by 1H-NMR spectroscopy, directly coupled HPLC-MS and HPLC-NMR, and circular dichroism.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(11-12):1075-89.
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2004: Lenz E M; Bright J; Wilson I D; Hughes A; Morrisson J; Lindberg H; Lockton A
Metabonomics, dietary influences and cultural differences: a 1H NMR-based study of urine samples obtained from healthy British and Swedish subjects.
Journal of pharmaceutical and biomedical analysis 2004;36(4):841-9.
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2004: Vanderhoeven S J; Troke J; Tranter G E; Wilson I D; Nicholson J K; Lindon J C
Nuclear magnetic resonance (NMR) and quantitative structure-activity relationship (QSAR) studies on the transacylation reactivity of model 1beta-O-acyl glucuronides. II: QSAR modelling of the reaction using both computational and experimental NMR parameters.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(10):889-900.
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2004: Nicholson Jeremy K; Holmes Elaine; Lindon John C; Wilson Ian D
The challenges of modeling mammalian biocomplexity.
Nature biotechnology 2004;22(10):1268-74.
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2004: Jensen Berit Packert; Smith Christopher J; Bailey Christopher; Rodgers Colin; Wilson Ian D; Nicholson Jeremy K
Application of inductively coupled plasma mass spectrometry and high-performance liquid chromatography--with parallel electrospray mass spectrometry to the investigation of the disposition and metabolic fate of 2-, 3- and 4-iodobenzoic acids in the rat.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;809(2):279-85.
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2004: Martin P D; Jones G R; Stringer F; Wilson I D
Comparison of extraction of a beta-blocker from plasma onto a molecularly imprinted polymer with liquid-liquid extraction and solid phase extraction methods.
Journal of pharmaceutical and biomedical analysis 2004;35(5):1231-9.
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2004: Coen Muireann; Wilson Ian D; Nicholson Jeremy K; Tang Huiru; Lindon John C
Probing molecular dynamics in chromatographic systems using high-resolution 1H magic-angle-spinning NMR spectroscopy: interaction between p-Xylene and C18-bonded silica.
Analytical chemistry 2004;76(11):3023-8.
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2004: Lenz E M; Bright J; Knight R; Wilson I D; Major H
A metabonomic investigation of the biochemical effects of mercuric chloride in the rat using 1H NMR and HPLC-TOF/MS: time dependent changes in the urinary profile of endogenous metabolites as a result of nephrotoxicity.
The Analyst 2004;129(6):535-41.
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2004: Lenz E M; Bright J; Knight R; Wilson I D; Major H
Cyclosporin A-induced changes in endogenous metabolites in rat urine: a metabonomic investigation using high field 1H NMR spectroscopy, HPLC-TOF/MS and chemometrics.
Journal of pharmaceutical and biomedical analysis 2004;35(3):599-608.
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2004: Coen Muireann; Ruepp Stefan U; Lindon John C; Nicholson Jeremy K; Pognan François; Lenz Eva M; Wilson Ian D
Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse.
Journal of pharmaceutical and biomedical analysis 2004;35(1):93-105.
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2004: Vanderhoeven S J; Lindon J C; Troke J; Tranter G E; Wilson I D; Nicholson J K
NMR and QSAR studies on the transacylation reactivity of model 1beta-O-acyl glucuronides. I: design, synthesis and degradation rate measurement.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(1):73-85.
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2004: Smith Christopher; Jensen Berit Packert; Wilson Ian D; Abou-Shakra Fadi; Crowther David
High-performance liquid chromatography/inductively coupled plasma mass spectrometry and tandem mass spectrometry for the detection of carbon-containing compounds.
Rapid communications in mass spectrometry : RCM 2004;18(13):1487-92.
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2004: Jensen Berit Packert; Smith Christopher; Wilson Ian D; Weidolf Lars
Sensitive sulphur-specific detection of omeprazole metabolites in rat urine by high-performance liquid chromatography/inductively coupled plasma mass spectrometry.
Rapid communications in mass spectrometry : RCM 2004;18(2):181-3.
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2003: Lenz E M; Bright J; Wilson I D; Morgan S R; Nash A F P
A 1H NMR-based metabonomic study of urine and plasma samples obtained from healthy human subjects.
Journal of pharmaceutical and biomedical analysis 2003;33(5):1103-15.
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2003: Wilson I D; Nicholson J K
Topics in Xenobiochemistry: do metabolic pathways exist for xenobiotics? The micro-metabolism hypothesis.
Xenobiotica; the fate of foreign compounds in biological systems 2003;33(9):887-901.
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2003: Major H; Castro-Perez J; Nicholson J K; Wilson I D
Detection of mono- and di-hexoses as metabolites of 4-bromoaniline using HPLC-TOF-MS/MS.
Xenobiotica; the fate of foreign compounds in biological systems 2003;33(8):855-69.
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2003: Nicholson Jeremy K; Wilson Ian D
Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism.
Nature reviews. Drug discovery 2003;2(8):668-76.
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2003: Plumb Robert; Granger Jennifer; Stumpf Chris; Wilson Ian D; Evans Julie A; Lenz Eva M
Metabonomic analysis of mouse urine by liquid-chromatography-time of flight mass spectrometry (LC-TOFMS): detection of strain, diurnal and gender differences.
The Analyst 2003;128(7):819-23.
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2003: Blackledge C A; Nicholson J K; Wilson I D
An NMR study of the metabolic fate of 2-, 3- and 4-fluorobenzyl alcohols in the rat: detection of N-acetylcysteinyl conjugates as minor metabolites in urine.
Journal of pharmaceutical and biomedical analysis 2003;32(1):133-40.
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2003: Martin Paul D; Jones Graeme R; Stringer Frances; Wilson Ian D
Comparison of normal and reversed-phase solid phase extraction methods for extraction of beta-blockers from plasma using molecularly imprinted polymers.
The Analyst 2003;128(4):345-50.
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2003: Smith Christopher J; Wilson Ian D; Abou-Shakra Fadi; Payne Richard; Parry Tony C; Sinclair Peta; Roberts David W
A comparison of the quantitative methods for the analysis of the platinum-containing anticancer drug [cis-[amminedichloro(2-methylpyridine)]platinum(II)] (ZD0473) by HPLC coupled to either a triple quadrupole mass spectrometer or an inductively coupled plasma mass spectrometer.
Analytical chemistry 2003;75(6):1463-9.
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2003: Coen Muireann; Lenz Eva M; Nicholson Jeremy K; Wilson Ian D; Pognan Francois; Lindon John C
An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy.
Chemical research in toxicology 2003;16(3):295-303.
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2003: Tugnait M; Lenz E M; Hofmann M; Spraul M; Wilson I D; Lindon J C; Nicholson J K
The metabolism of 2-trifluormethylaniline and its acetanilide in the rat by 19F NMR monitored enzyme hydrolysis and 1H/19F HPLC-NMR spectroscopy.
Journal of pharmaceutical and biomedical analysis 2003;30(5):1561-74.
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2003: Duckett Catherine J; Wilson Ian D; Walker Heather; Abou-Shakra Fadi; Lindon John C; Nicholson Jeremy K
High-performance liquid chromatography/inductively coupled plasma mass spectrometry with iodine-specific detection for profiling the metabolites produced in the earthworm Eisenia veneta by exposure to 2-fluoro-4-iodoaniline.
Rapid communications in mass spectrometry : RCM 2003;17(16):1855-8.
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2003: Major Hilary; Castro-Perez Jose; Nicholson Jeremy K; Wilson Ian D
Characterisation of putative pentose-containing conjugates as minor metabolites of 4-bromoaniline present in the urine of rats following intraperitoneal administration.
Rapid communications in mass spectrometry : RCM 2003;17(1):76-80.
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2002: Gavaghan C L; Wilson I D; Nicholson J K
Physiological variation in metabolic phenotyping and functional genomic studies: use of orthogonal signal correction and PLS-DA.
FEBS letters 2002;530(1-3):191-6.
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2002: Blackledge C A; Nicholson J K; Evans J A; Rodgers C; Wilson I D
Application of (1)H- and (19)F-NMR spectroscopy in the investigation of the urinary and biliary excretion of 3,5-, 2,4-ditrifluoromethylbenzoic and pentafluorobenzoic acids in rat.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(7):605-13.
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2002: Tugnait M; Lenz E M; Phillips P; Hofmann M; Spraul M; Lindon J C; Nicholson J K; Wilson I D
The metabolism of 4-trifluoromethoxyaniline and [13C]-4-trifluoromethoxyacetanilide in the rat: detection and identification of metabolites excreted in the urine by NMR and HPLC-NMR.
Journal of pharmaceutical and biomedical analysis 2002;28(5):875-85.
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2002: Scarfe G B; Nicholson J K; Lindon J C; Wilson I D; Taylor S; Clayton E; Wright B
Identification of the urinary metabolites of 4-bromoaniline and 4-bromo-[carbonyl-13C]-acetanilide in rat.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(4):325-37.
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2002: Scarfe G B; Wilson I D; Warne M A; Holmes E; Nicholson J K; Lindon J C
Structure-metabolism relationships of substituted anilines: prediction of N-acetylation and N-oxanilic acid formation using computational chemistry.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(4):267-77.
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2002: Lenz E M; Wilson I D; Wright B; Partridge E A; Rodgers C T; Haycock P R; Lindon J C; Nicholson J K
A comparison of quantitative NMR and radiolabelling studies of the metabolism and excretion of Statil (3-(4-bromo-2-fluorobenzyl)-4-oxo-3H-phthalazin-1-ylacetic acid) in the rat.
Journal of pharmaceutical and biomedical analysis 2002;28(1):31-43.
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2002: Duckett Catherine J; Bailey Nigel J C; Walker Heather; Abou-Shakra Fadi; Wilson Ian D; Lindon John C; Nicholson Jeremy K
Quantitation in gradient high performance liquid chromatography/inductively coupled mass spectrometry investigated using diclofenac and chlorpromazine.
Rapid communications in mass spectrometry : RCM 2002;16(4):245-7.
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2001: Martin P D; Wilson T D; Wilson I D; Jones G R
An unexpected selectivity of a propranolol-derived molecular imprint for tamoxifen.
The Analyst 2001;126(6):757-9.
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2001: Coen M; Lindon J C; Gavaghan C; Holmes E; Humpfer E; Wilson I D; Stanley P D; Nicholson J K
Investigation of water environments in a C18 bonded silica phase using 1H magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy.
The Analyst 2001;126(5):548-50.
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2001: Gavaghan C L; Nicholson J K; Connor S C; Wilson I D; Wright B; Holmes E
Directly coupled high-performance liquid chromatography and nuclear magnetic resonance spectroscopic with chemometric studies on metabolic variation in Sprague--Dawley rats.
Analytical biochemistry 2001;291(2):245-52.
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2001: Nicholson J K; Lindon J C; Scarfe G B; Wilson I D; Abou-Shakra F; Sage A B; Castro-Perez J
High-performance liquid chromatography linked to inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry for the simultaneous detection and identification of metabolites of 2-bromo-4-trifluoromethyl.
Analytical chemistry 2001;73(7):1491-4.
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2000: Scarfe G B; Clayton E; Wilson I D; Nicholson J K
Identification and quantification of metabolites of 2,3,5,6-tetrafluoro-4-trifluoromethylaniline in rat urine using 19F nuclear magnetic resonance spectroscopy, high-performance liquid chromatography-nuclear magnetic resonance spectroscopy and high-performance liquid chromatography-mass spectrometry.
Journal of chromatography. B, Biomedical sciences and applications 2000;748(1):311-9.
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2000: Lindon J C; Nicholson J K; Wilson I D
Directly coupled HPLC-NMR and HPLC-NMR-MS in pharmaceutical research and development.
Journal of chromatography. B, Biomedical sciences and applications 2000;748(1):233-58.
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2000: Scarfe G B; Lindon J C; Nicholson J K; Martin P; Wright B; Taylor S; Lenz E; Wilson I D
Investigation of the metabolism of 14C/13C-practolol in rat using directly coupled radio-HPLC-NMR-MS.
Xenobiotica; the fate of foreign compounds in biological systems 2000;30(7):717-29.
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2000: Nicholson J K; Lindon J C; Scarfe G; Wilson I D; Abou-Shakra F; Castro-Perez J; Eaton A; Preece S
High-performance liquid chromatography and inductively coupled plasma mass spectrometry (HPLC-ICP-MS) for the analysis of xenobiotic metabolites in rat urine: application to the metabolites of 4-bromoaniline.
The Analyst 2000;125(2):235-6.
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2000: Bailey N J; Cooper P; Hadfield S T; Lenz E M; Lindon J C; Nicholson J K; Stanley P D; Wilson I D; Wright B; Taylor S D
Application of directly coupled HPLC-NMR-MS/MS to the identification of metabolites of 5-trifluoromethylpyridone (2-hydroxy-5-trifluoromethylpyridine) in hydroponically grown plants.
Journal of agricultural and food chemistry 2000;48(1):42-6.
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2000: Corcoran O; Nicholson J K; Lenz E M; Abou-Shakra F; Castro-Perez J; Sage A B; Wilson I D
Directly coupled liquid chromatography with inductively coupled plasma mass spectrometry and orthogonal acceleration time-of-flight mass spectrometry for the identification of drug metabolites in urine: application to diclofenac using chlorine and sulfur detection.
Rapid communications in mass spectrometry : RCM 2000;14(24):2377-84.
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1999: Scarfe G B; Lindon J C; Nicholson J K; Wright B; Clayton E; Wilson I D
Investigation of the quantitative metabolic fate and urinary excretion of 3-methyl-4-trifluoromethylaniline and 3-methyl-4-trifluoromethylacetanilide in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(10):1171-8.
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1999: Nicholls A W; Lindon J C; Farrant R D; Shockcor J P; Wilson I D; Nicholson J K
Directly-coupled HPLC-NMR spectroscopic studies of metabolism and futile deacetylation of phenacetin in the rat.
Journal of pharmaceutical and biomedical analysis 1999;20(6):865-73.
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1999: Scarfe G B; Tugnait M; Wilson I D; Nicholson J K
Studies on the metabolism of 4-fluoroaniline and 4-fluoroacetanilide in rat: formation of 4-acetamidophenol (paracetamol) and its metabolites via defluorination and N-acetylation.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(2):205-16.
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1999: Scarfe G B; Wright B; Clayton E; Taylor S; Wilson I D; Lindon J C; Nicholson J K
Quantitative studies on the urinary metabolic fate of 2-chloro-4-trifluoromethylaniline in the rat using 19F-NMR spectroscopy and directly coupled HPLC-NMR-MS.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(1):77-91.
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1999: Cupid B C; Holmes E; Wilson I D; Lindon J C; Nicholson J K
Quantitative structure-metabolism relationships (QSMR) using computational chemistry: pattern recognition analysis and statistical prediction of phase II conjugation reactions of substituted benzoic acids in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(1):27-42.
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1998: Schewitz J; Gfrörer P; Pusecker K; Tseng L H; Albert K; Bayer E; Wilson I D; Bailey N J; Scarfe G B; Nicholson J K; Lindon J C
Directly coupled CZE-NMR and CEC-NMR spectroscopy for metabolite analysis: paracetamol metabolites in human urine.
The Analyst 1998;123(12):2835-7.
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1998: Scarfe G B; Wright B; Clayton E; Taylor S; Wilson I D; Lindon J C; Nicholson J K
19F-NMR and directly coupled HPLC-NMR-MS investigations into the metabolism of 2-bromo-4-trifluoromethylaniline in rat: a urinary excretion balance study without the use of radiolabelling.
Xenobiotica; the fate of foreign compounds in biological systems 1998;28(4):373-88.
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1997: Nicholls A W; Lindon J C; Caddick S; Farrant R D; Wilson I D; Nicholson J K
NMR spectroscopic studies on the metabolism and futile deacetylation of phenacetin in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1997;27(11):1175-86.
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1997: Lindon J C; Nicholson J K; Sidelmann U G; Wilson I D
Directly coupled HPLC-NMR and its application to drug metabolism.
Drug metabolism reviews 1997;29(3):705-46.
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1997: Nicholls A W; Farrant R D; Shockcor J P; Unger S E; Wilson I D; Lindon J C; Nicholson J K
NMR and HPLC-NMR spectroscopic studies of futile deacetylation in paracetamol metabolites in rat and man.
Journal of pharmaceutical and biomedical analysis 1997;15(7):901-10.
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1996: Shockcor J P; Unger S E; Wilson I D; Foxall P J; Nicholson J K; Lindon J C
Combined HPLC, NMR spectroscopy, and ion-trap mass spectrometry with application to the detection and characterization of xenobiotic and endogenous metabolites in human urine.
Analytical chemistry 1996;68(24):4431-5.
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1996: Nicholls A W; Akira K; Lindon J C; Farrant R D; Wilson I D; Harding J; Killick D A; Nicholson J K
NMR spectroscopic and theoretical chemistry studies on the internal acyl migration reactions of the 1-O-acyl-beta-D-glucopyranuronate conjugates of 2-, 3-, and 4-(trifluoromethyl) benzoic acids.
Chemical research in toxicology 1996;9(8):1414-24.
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1996: Sidelmann U; Hansen S H; Gavaghan C; Nicholls A W; Carless H A; Lindon J C; Wilson I D; Nicholson J K
Development of a simple liquid chromatographic method for the separation of mixtures of positional isomers and anomers of synthetic 2-, 3- and 4-fluorobenzoic acid glucuronides formed via acyl migration reactions.
Journal of chromatography. B, Biomedical applications 1996;685(1):113-22.
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1996: Lenz E M; Greatbanks D; Wilson I D; Spraul M; Hofmann M; Troke J; Lindon J C; Nicholson J K
Direct characterization of drug glucuronide isomers in human urine by HPLC-NMR spectroscopy: application to the positional isomers of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid glucuronide.
Analytical chemistry 1996;68(17):2832-7.
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1996: Foxall P J; Lenz E M; Lindon J C; Neild G H; Wilson I D; Nicholson J K
Nuclear magnetic resonance and high-performance liquid chromatography-nuclear magnetic resonance studies on the toxicity and metabolism of ifosfamide.
Therapeutic drug monitoring 1996;18(4):498-505.
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1996: Bollard M E; Holmes E; Blackledge C A; Lindon J C; Wilson I D; Nicholson J K
1H and 19F-nmr spectroscopic studies on the metabolism and urinary excretion of mono- and disubstituted phenols in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(3):255-73.
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1996: Cupid B C; Beddell C R; Lindon J C; Wilson I D; Nicholson J K
Quantitative structure-metabolism relationships for substituted benzoic acids in the rabbit: prediction of urinary excretion of glycine and glucuronide conjugates.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(2):157-76.
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1996: Sidelmann U G; Lenz E M; Spraul M; Hofmann M; Troke J; Sanderson P N; Lindon J C; Wilson I D; Nicholson J K
750 MHz HPLC-NMR spectroscopic studies on the separation and characterization of the positional isomers of the glucuronides of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid.
Analytical chemistry 1996;68(1):106-10.
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1995: Holmes E; Sweatman B C; Bollard M E; Blackledge C A; Beddell C R; Wilson I D; Lindon J C; Nicholson J K
Prediction of urinary sulphate and glucuronide conjugate excretion for substituted phenols in the rat using quantitative structure-metabolism relationships.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(12):1269-81.
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1995: Farrant R D; Spraul M; Wilson I D; Nicholls A W; Nicholson J K; Lindon J C
Assignment of the 750 MHz 1H NMR resonances from a mixture of transacylated ester glucuronic acid conjugates with the aid of oversampling and digital filtering during acquisition.
Journal of pharmaceutical and biomedical analysis 1995;13(8):971-7.
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1995: Holmes E; Caddick S; Lindon J C; Wilson I D; Kryvawych S; Nicholson J K
1H and 2H NMR spectroscopic studies on the metabolism and biochemical effects of 2-bromoethanamine in the rat.
Biochemical pharmacology 1995;49(10):1349-59.
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1995: Nicholls A W; Caddick S; Wilson I D; Farrant R D; Lindon J C; Nicholson J K
High resolution NMR spectroscopic studies on the metabolism and futile deacetylation of 4-hydroxyacetanilide (paracetamol) in the rat.
Biochemical pharmacology 1995;49(8):1155-64.
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1994: Seddon M J; Spraul M; Wilson I D; Nicholson J K; Lindon J C
Improvement in the characterization of minor drug metabolites from HPLC-NMR studies through the use of quantified maximum entropy processing of NMR spectra.
Journal of pharmaceutical and biomedical analysis 1994;12(3):419-24.
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1993: Ghauri F Y; McLean A E; Beales D; Wilson I D; Nicholson J K
Induction of 5-oxoprolinuria in the rat following chronic feeding with N-acetyl 4-aminophenol (paracetamol).
Biochemical pharmacology 1993;46(5):953-7.
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1993: Ghauri F Y; Parkes H G; Nicholson J K; Wilson I D; Brenton D P
Asymptomatic 5-oxoprolinuria detected by proton magnetic resonance spectroscopy.
Clinical chemistry 1993;39(6):1341.
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1992: Ghauri F Y; Blackledge C A; Glen R C; Sweatman B C; Lindon J C; Beddell C R; Wilson I D; Nicholson J K
Quantitative structure-metabolism relationships for substituted benzoic acids in the rat. Computational chemistry, NMR spectroscopy and pattern recognition studies.
Biochemical pharmacology 1992;44(10):1935-46.
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1991: Tugnait M; Ghauri F Y; Wilson I D; Nicholson J K
NMR-monitored solid-phase extraction of phenolphthalein glucuronide on phenylboronic acid and C18 bonded phases.
Journal of pharmaceutical and biomedical analysis 1991;9(10-12):895-9.
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1990: Ghauri F Y; Blackledge C A; Wilson I D; Nicholson J K
Studies on the metabolism of fluorinated xenobiotics in the rat using 19F-NMR and 1H-NMR spectroscopy.
Journal of pharmaceutical and biomedical analysis 1990;8(8-12):939-44.
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1990: Wade K E; Wilson I D; Troke J A; Nicholson J K
19F and 1H magnetic resonance strategies for metabolic studies on fluorinated xenobiotics: application to flurbiprofen [2-(2-fluoro-4-biphenylyl)propionic acid]
Journal of pharmaceutical and biomedical analysis 1990;8(5):401-10.
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1987: Wilson I D; Fromson J M; Illing H P; Schraven E
The metabolism of [14C]N-ethoxycarbonyl-3-morpholinosydnonimine (molsidomine) in man.
Xenobiotica; the fate of foreign compounds in biological systems 1987;17(1):93-104.
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1986: Wilson I D; Watson K V; Troke J; Illing H P; Fromson J M
The metabolism of [14C]N-ethoxycarbonyl-3-morpholinosydnonimine (molsidomine) in laboratory animals.
Xenobiotica; the fate of foreign compounds in biological systems 1986;16(12):1117-28.
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1985: Wilson I D; Macdonald C M; Fromson J M; Troke J A; Hillbeck D
Species differences in the metabolism of 14C-p-trifluoromethylaniline: production of an oxanilic acid as the major metabolite by the rat.
Biochemical pharmacology 1985;34(11):2025-8.
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1981: Illing H P; Wilson I D
pH dependent formation of beta-glucuronidase resistant conjugates from the biosynthetic ester glucuronide of isoxepac.
Biochemical pharmacology 1981;30(24):3381-4.
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