Martin Brechbiel

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Herbertson Rebecca A; Tebbutt Niall C; Lee Fook-Thean; MacFarlane David J; Chappell Bridget; Micallef Noel; Lee Sze-Ting; Saunder Timothy; Hopkins Wendie; Smyth Fiona E; Wyld David K; Bellen John; Sonnichsen Daryl S; Brechbiel Martin W; Murone Carmel; Scott Andrew M
Phase I biodistribution and pharmacokinetic study of Lewis Y-targeting immunoconjugate CMD-193 in patients with advanced epithelial cancers.
Ray G L; Baidoo K E; Wong K J; Williams M; Garmestani K; Brechbiel M W; Milenic D E
Preclinical evaluation of a monoclonal antibody targeting the epidermal growth factor receptor as a radioimmunodiagnostic and radioimmunotherapeutic agent.
Nwe Kido; Xu Heng; Regino Celeste Aida S; Bernardo Marcelino; Ileva Lilia; Riffle Lisa; Wong Karen J; Brechbiel Martin W
A new approach in the preparation of dendrimer-based bifunctional diethylenetriaminepentaacetic acid MR contrast agent derivatives.

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2009: Herbertson Rebecca A; Tebbutt Niall C; Lee Fook-Thean; MacFarlane David J; Chappell Bridget; Micallef Noel; Lee Sze-Ting; Saunder Timothy; Hopkins Wendie; Smyth Fiona E; Wyld David K; Bellen John; Sonnichsen Daryl S; Brechbiel Martin W; Murone Carmel; Scott Andrew M
Phase I biodistribution and pharmacokinetic study of Lewis Y-targeting immunoconjugate CMD-193 in patients with advanced epithelial cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(21):6709-15.
2009: Ray G L; Baidoo K E; Wong K J; Williams M; Garmestani K; Brechbiel M W; Milenic D E
Preclinical evaluation of a monoclonal antibody targeting the epidermal growth factor receptor as a radioimmunodiagnostic and radioimmunotherapeutic agent.
British journal of pharmacology 2009;157(8):1541-8.
2009: Nwe Kido; Xu Heng; Regino Celeste Aida S; Bernardo Marcelino; Ileva Lilia; Riffle Lisa; Wong Karen J; Brechbiel Martin W
A new approach in the preparation of dendrimer-based bifunctional diethylenetriaminepentaacetic acid MR contrast agent derivatives.
Bioconjugate chemistry 2009;20(7):1412-8.
2009: Xu Heng; Eck Peter K; Baidoo Kwamena E; Choyke Peter L; Brechbiel Martin W
Toward preparation of antibody-based imaging probe libraries for dual-modality positron emission tomography and fluorescence imaging.
Bioorganic & medicinal chemistry 2009;17(14):5176-81.
2009: Zhang Meili; Yao Zhengsheng; Garmestani Kayhan; Yu Sarah; Goldman Carolyn K; Paik Chang H; Brechbiel Martin W; Carrasquillo Jorge A; Waldmann Thomas A
Preclinical evaluation of an anti-CD25 monoclonal antibody, 7G7/B6, armed with the beta-emitter, yttrium-90, as a radioimmunotherapeutic agent for treating lymphoma.
Cancer biotherapy & radiopharmaceuticals 2009;24(3):303-9.
2009: Nwe Kido; Brechbiel Martin W
Growing applications of "click chemistry" for bioconjugation in contemporary biomedical research.
Cancer biotherapy & radiopharmaceuticals 2009;24(3):289-302.
2009: Wei Lihui; Zhang Xiuli; Gallazzi Fabio; Miao Yubin; Jin Xiaofang; Brechbiel Martin W; Xu Heng; Clifford Thomas; Welch Michael J; Lewis Jason S; Quinn Thomas P
Melanoma imaging using (111)In-, (86)Y- and (68)Ga-labeled CHX-A''-Re(Arg11)CCMSH.
Nuclear medicine and biology 2009;36(4):345-54.
2009: Boswell C Andrew; Regino Celeste A S; Baidoo Kwamena E; Wong Karen J; Milenic Diane E; Kelley James A; Lai Christopher C; Brechbiel Martin W
A novel side-bridged hybrid phosphonate/acetate pendant cyclam: synthesis, characterization, and 64Cu small animal PET imaging.
Bioorganic & medicinal chemistry 2009;17(2):548-52.
2009: Kelly Marcus P; Lee Sze Ting; Lee F-T; Smyth Fiona E; Davis Ian D; Brechbiel Martin W; Scott Andrew M
Therapeutic efficacy of 177Lu-CHX-A''-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy.
The Prostate 2009;69(1):92-104.
2008: Chong Hyun-Soon; Lim Sooyoun; Baidoo Kwamena E; Milenic Diane E; Ma Xiang; Jia Fang; Song Hyun A; Brechbiel Martin W; Lewis Michael R
Synthesis and biological evaluation of a novel decadentate ligand DEPA.
Bioorganic & medicinal chemistry letters 2008;18(21):5792-5.
2008: Milenic Diane E; Wong Karen J; Baidoo Kwamena E; Ray Geoffrey L; Garmestani Kayhan; Williams Mark; Brechbiel Martin W
Cetuximab: preclinical evaluation of a monoclonal antibody targeting EGFR for radioimmunodiagnostic and radioimmunotherapeutic applications.
Cancer biotherapy & radiopharmaceuticals 2008;23(5):619-31.
2008: Kelly Marcus P; Lee F-T; Tahtis Kiki; Power Barbara E; Smyth Fiona E; Brechbiel Martin W; Hudson Peter J; Scott Andrew M
Tumor targeting by a multivalent single-chain Fv (scFv) anti-Lewis Y antibody construct.
Cancer biotherapy & radiopharmaceuticals 2008;23(4):411-23.
2008: Milenic Diane E; Garmestani Kayhan; Brady Erik D; Baidoo Kwamena E; Albert Paul S; Wong Karen J; Flynn Joseph; Brechbiel Martin W
Multimodality therapy: potentiation of high linear energy transfer radiation with paclitaxel for the treatment of disseminated peritoneal disease.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(16):5108-15.
2008: Tolmachev Vladimir; Xu Heng; Wållberg Helena; Ahlgren Sara; Hjertman Magnus; Sjöberg Anna; Sandström Mattias; Abrahmsén Lars; Brechbiel Martin W; Orlova Anna
Evaluation of a maleimido derivative of CHX-A'' DTPA for site-specific labeling of affibody molecules.
Bioconjugate chemistry 2008;19(8):1579-87.
2008: Boswell C Andrew; Regino Celeste A S; Baidoo Kwamena E; Wong Karen J; Bumb Ambika; Xu Heng; Milenic Diane E; Kelley James A; Lai Christopher C; Brechbiel Martin W
Synthesis of a cross-bridged cyclam derivative for peptide conjugation and 64Cu radiolabeling.
Bioconjugate chemistry 2008;19(7):1476-84.
2008: Chong Hyun-Soon; Song Hyun A; Ma Xiang; Milenic Diane E; Brady Erik D; Lim Sooyoun; Lee Haisung; Baidoo Kwamena; Cheng Dengfeng; Brechbiel Martin W
Novel bimodal bifunctional ligands for radioimmunotherapy and targeted MRI.
Bioconjugate chemistry 2008;19(7):1439-47.
2008: Boswell C Andrew; Eck Peter K; Regino Celeste A S; Bernardo Marcelino; Wong Karen J; Milenic Diane E; Choyke Peter L; Brechbiel Martin W
Synthesis, characterization, and biological evaluation of integrin alphavbeta3-targeted PAMAM dendrimers.
Molecular pharmaceutics 2008;5(4):527-39.
2008: Brechbiel M W
Bifunctional chelates for metal nuclides.
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology 2008;52(2):166-73.
2008: Xu Heng; Baidoo Kwamena E; Wong Karen J; Brechbiel Martin W
A novel bifunctional maleimido CHX-A'' chelator for conjugation to thiol-containing biomolecules.
Bioorganic & medicinal chemistry letters 2008;18(8):2679-83.
2008: Robinson Matthew K; Shaller Calvin; Garmestani Kayhan; Plascjak Paul S; Hodge Kathryn M; Yuan Qing-An; Marks James D; Waldmann Thomas A; Brechbiel Martin W; Adams Gregory P
Effective treatment of established human breast tumor xenografts in immunodeficient mice with a single dose of the alpha-emitting radioisotope astatine-211 conjugated to anti-HER2/neu diabodies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(3):875-82.
2008: Regino Celeste Aida S; Walbridge Stuart; Bernardo Marcelino; Wong Karen J; Johnson Dennis; Lonser Russell; Oldfield Edward H; Choyke Peter L; Brechbiel Martin W
A dual CT-MR dendrimer contrast agent as a surrogate marker for convection-enhanced delivery of intracerebral macromolecular therapeutic agents.
Contrast media & molecular imaging 2008;3(1):2-8.
2008: Wilbur D Scott; Hamlin Donald K; Chyan Ming-Kuan; Brechbiel Martin W
Streptavidin in antibody pretargeting. 5. chemical modification of recombinant streptavidin for labeling with the alpha-particle-emitting radionuclides 213Bi and 211At.
Bioconjugate chemistry 2008;19(1):158-70.
2008: Chong Hyun-Soon; Ma Xiang; Le Thien; Kwamena Baidoo; Milenic Diane E; Brady Erik D; Song Hyun A; Brechbiel Martin W
Rational design and generation of a bimodal bifunctional ligand for antibody-targeted radiation cancer therapy.
Journal of medicinal chemistry 2008;51(1):118-25.
2008: Childers Matt L; Cho Joonhyung; Regino Celeste A S; Brechbiel Martin W; DiPasquale Antonio G; Rheingold Arnold L; Torti Suzy V; Torti Frank M; Planalp Roy P
Influence of ligand structure on Fe(II) spin-state and redox rate in cytotoxic tripodal chelators.
Journal of inorganic biochemistry 2008;102(1):150-6.
2007: Brechbiel Martin W
Targeted alpha-therapy: past, present, future?
Dalton transactions (Cambridge, England : 2003) 2007;(43):4918-28.
2007: Chong Hyun-Soon; Mhaske Santosh; Lin Mai; Bhuniya Sankar; Song Hyun A; Brechbiel Martin W; Sun Xiankai
Novel synthetic ligands for targeted PET imaging and radiotherapy of copper.
Bioorganic & medicinal chemistry letters 2007;17(22):6107-10.
2007: Boswell C Andrew; Brechbiel Martin W
Development of radioimmunotherapeutic and diagnostic antibodies: an inside-out view.
Nuclear medicine and biology 2007;34(7):757-78.
2007: Kelly Marcus P; Lee Fook T; Tahtis Kiki; Smyth Fiona E; Brechbiel Martin W; Scott Andrew M
Radioimmunotherapy with alpha-particle emitting 213Bi-C-functionalized trans-cyclohexyl-diethylenetriaminepentaacetic acid-humanized 3S193 is enhanced by combination with paclitaxel chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(18 Pt 2):5604s-5612s.
2007: Xu Heng; Baidoo Kwamena; Gunn Andrew J; Boswell C Andrew; Milenic Diane E; Choyke Peter L; Brechbiel Martin W
Design, synthesis, and characterization of a dual modality positron emission tomography and fluorescence imaging agent for monoclonal antibody tumor-targeted imaging.
Journal of medicinal chemistry 2007;50(19):4759-65.
2007: Xu Heng; Regino Celeste A S; Koyama Yoshinori; Hama Yukihiro; Gunn Andrew J; Bernardo Marcelino; Kobayashi Hisataka; Choyke Peter L; Brechbiel Martin W
Preparation and preliminary evaluation of a biotin-targeted, lectin-targeted dendrimer-based probe for dual-modality magnetic resonance and fluorescence imaging.
Bioconjugate chemistry 2007;18(5):1474-82.
2007: Vallera Daniel A; Sicheneder Andy R; Taras Elizabeth P; Brechbiel Martin W; Vallera Jesse A; Panoskaltsis-Mortari Angela; Burns Linda J
Radiotherapy of CD45-expressing Daudi tumors in nude mice with yttrium-90-labeled, PEGylated anti-CD45 antibody.
Cancer biotherapy & radiopharmaceuticals 2007;22(4):488-500.
2007: Barrett Tristan; Brechbiel Martin; Bernardo Marcelino; Choyke Peter L
MRI of tumor angiogenesis.
Journal of magnetic resonance imaging : JMRI 2007;26(2):235-49.
2007: Gunn Andrew J; Brechbiel Martin W; Choyke Peter L
The emerging role of molecular imaging and targeted therapeutics in peritoneal carcinomatosis.
Expert opinion on drug delivery 2007;4(4):389-402.
2007: Xu Heng; Regino Celeste A S; Bernardo Marcelino; Koyama Yoshinori; Kobayashi Hisataka; Choyke Peter L; Brechbiel Martin W
Toward improved syntheses of dendrimer-based magnetic resonance imaging contrast agents: new bifunctional diethylenetriaminepentaacetic acid ligands and nonaqueous conjugation chemistry.
Journal of medicinal chemistry 2007;50(14):3185-93.
2007: Song Emma Y; Abbas Rizvi Syed M; Qu Chang F; Raja Chand; Brechbiel Martin W; Morgenstern Alfred; Apostolidis Christos; Allen Barry J
Pharmacokinetics and toxicity of (213)Bi-labeled PAI2 in preclinical targeted alpha therapy for cancer.
Cancer biology & therapy 2007;6(6):898-904.
2007: Scott Andrew M; Tebbutt Niall; Lee Fook-Thean; Cavicchiolo Tina; Liu Zhanqi; Gill Sanjeev; Poon Aurora M T; Hopkins Wendie; Smyth Fiona E; Murone Carmel; MacGregor Duncan; Papenfuss Anthony T; Chappell Bridget; Saunder Timothy H; Brechbiel Martin W; Davis Ian D; Murphy Roger; Chong Geoffrey; Hoffman Eric W; Old Lloyd J
A phase I biodistribution and pharmacokinetic trial of humanized monoclonal antibody Hu3s193 in patients with advanced epithelial cancers that express the Lewis-Y antigen.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(11):3286-92.
2007: Zhang Meili; Yao Zhengsheng; Patel Hiral; Garmestani Kayhan; Zhang Zhuo; Talanov Vladimir S; Plascjak Paul S; Goldman Carolyn K; Janik John E; Brechbiel Martin W; Waldmann Thomas A
Effective therapy of murine models of human leukemia and lymphoma with radiolabeled anti-CD30 antibody, HeFi-1.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(20):8444-8.
2007: Koyama Yoshinori; Talanov Vladimir S; Bernardo Marcelino; Hama Yukihiro; Regino Celeste A S; Brechbiel Martin W; Choyke Peter L; Kobayashi Hisataka
A dendrimer-based nanosized contrast agent dual-labeled for magnetic resonance and optical fluorescence imaging to localize the sentinel lymph node in mice.
Journal of magnetic resonance imaging : JMRI 2007;25(4):866-71.
2007: Milenic Diane E; Garmestani Kayhan; Brady Erik D; Albert Paul S; Abdulla Alia; Flynn Joseph; Brechbiel Martin W
Potentiation of high-LET radiation by gemcitabine: targeting HER2 with trastuzumab to treat disseminated peritoneal disease.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(6):1926-35.
2007: Scott Andrew M; Lee Fook-Thean; Tebbutt Niall; Herbertson Rebecca; Gill Sanjeev S; Liu Zhanqi; Skrinos Effie; Murone Carmel; Saunder Timothy H; Chappell Bridget; Papenfuss Anthony T; Poon Aurora M T; Hopkins Wendie; Smyth Fiona E; MacGregor Duncan; Cher Lawrence M; Jungbluth Achim A; Ritter Gerd; Brechbiel Martin W; Murphy Roger; Burgess Antony W; Hoffman Eric W; Johns Terrance G; Old Lloyd J
A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4071-6.
2007: Hama Yukihiro; Bernardo Marcelino; Regino Celeste A S; Koyama Yoshinori; Brechbiel Martin W; Krishna Murali C; Choyke Peter L; Kobayashi Hisataka
MR lymphangiography using dendrimer-based contrast agents: a comparison at 1.5T and 3.0T.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2007;57(2):431-6.
2006: Barrett Tristan; Kobayashi Hisataka; Brechbiel Martin; Choyke Peter L
Macromolecular MRI contrast agents for imaging tumor angiogenesis.
European journal of radiology 2006;60(3):353-66.
2006: Dadachova Ekaterina; Patel Mahesh C; Toussi Sima; Apostolidis Christos; Morgenstern Alfred; Brechbiel Martin W; Gorny Miroslaw K; Zolla-Pazner Susan; Casadevall Arturo; Goldstein Harris
Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins.
PLoS medicine 2006;3(11):e427.
2006: Zhang Meili; Yao Zhengsheng; Zhang Zhuo; Garmestani Kayhan; Talanov Vladimir S; Plascjak Paul S; Yu Sarah; Kim Hyung-Sik; Goldman Carolyn K; Paik Chang H; Brechbiel Martin W; Carrasquillo Jorge A; Waldmann Thomas A
The anti-CD25 monoclonal antibody 7G7/B6, armed with the alpha-emitter 211At, provides effective radioimmunotherapy for a murine model of leukemia.
Cancer research 2006;66(16):8227-32.
2006: Zhang Zhuo; Zhang Meili; Garmestani Kayhan; Talanov Vladimir S; Plascjak Paul S; Beck Barbara; Goldman Carolyn; Brechbiel Martin W; Waldmann Thomas A
Effective treatment of a murine model of adult T-cell leukemia using 211At-7G7/B6 and its combination with unmodified anti-Tac (daclizumab) directed toward CD25.
Blood 2006;108(3):1007-12.
2006: Talanov Vladimir S; Regino Celeste A S; Kobayashi Hisataka; Bernardo Marcelino; Choyke Peter L; Brechbiel Martin W
Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging.
Nano letters 2006;6(7):1459-63.
2006: Clifford Thomas; Boswell C Andrew; Biddlecombe Grainne B; Lewis Jason S; Brechbiel Martin W
Validation of a novel CHX-A'' derivative suitable for peptide conjugation: small animal PET/CT imaging using yttrium-86-CHX-A''-octreotide.
Journal of medicinal chemistry 2006;49(14):4297-304.
2006: Zhang Meili; Yao Zhengsheng; Zhang Zhuo; Garmestani Kayhan; Goldman Carolyn K; Ravetch Jeffrey V; Janik John; Brechbiel Martin W; Waldmann Thomas A
Effective therapy for a murine model of human anaplastic large-cell lymphoma with the anti-CD30 monoclonal antibody, HeFi-1, does not require activating Fc receptors.
Blood 2006;108(2):705-10.
2006: Talanov Vladimir S; Garmestani Kayhan; Regino Celeste A S; Milenic Diane E; Plascjak Paul S; Waldmann Thomas A; Brechbiel Martin W
Preparation and in vivo evaluation of a novel stabilized linker for 211At labeling of protein.
Nuclear medicine and biology 2006;33(4):469-80.
2006: Chong Hyun-Soon; Milenic Diane E; Garmestani Kayhan; Brady Erik D; Arora Hans; Pfiester Candice; Brechbiel Martin W
In vitro and in vivo evaluation of novel ligands for radioimmunotherapy.
Nuclear medicine and biology 2006;33(4):459-67.
2006: Murad Gregory J A; Walbridge Stuart; Morrison Paul F; Garmestani Kayhan; Degen Jeffrey W; Brechbiel Martin W; Oldfield Edward H; Lonser Russell R
Real-time, image-guided, convection-enhanced delivery of interleukin 13 bound to pseudomonas exotoxin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(10):3145-51.
2006: Kelly Marcus P; Lee Fook T; Smyth Fiona E; Brechbiel Martin W; Scott Andrew M
Enhanced efficacy of 90Y-radiolabeled anti-Lewis Y humanized monoclonal antibody hu3S193 and paclitaxel combined-modality radioimmunotherapy in a breast cancer model.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(4):716-25.
2006: Kobayashi Hisataka; Kawamoto Satomi; Bernardo Marcelino; Brechbiel Martin W; Knopp Michael V; Choyke Peter L
Delivery of gadolinium-labeled nanoparticles to the sentinel lymph node: comparison of the sentinel node visualization and estimations of intra-nodal gadolinium concentration by the magnetic resonance imaging.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(3):343-51.
2006: Chong Hyun-Soon; Garmestani Kayhan; Bryant L Henry; Milenic Diane E; Overstreet Terrish; Birch Noah; Le Thien; Brady Erik D; Brechbiel Martin W
Synthesis and evaluation of novel macrocyclic and acyclic ligands as contrast enhancement agents for magnetic resonance imaging.
Journal of medicinal chemistry 2006;49(6):2055-62.
2006: Norenberg Jeffrey P; Krenning Boudewijn J; Konings Inge R H M; Kusewitt Donna F; Nayak Tapan K; Anderson Tamara L; de Jong Marion; Garmestani Kayhan; Brechbiel Martin W; Kvols Larry K
213Bi-[DOTA0, Tyr3]octreotide peptide receptor radionuclide therapy of pancreatic tumors in a preclinical animal model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(3 Pt 1):897-903.
2006: Wong Rosemary S L; Brechbiel Martin W
National cancer institute perspectives.
International journal of radiation oncology, biology, physics 2006;66(2 Suppl):S96-9.
2006: Dear James W; Kobayashi Hisataka; Brechbiel Martin W; Star Robert A
Imaging acute renal failure with polyamine dendrimer-based MRI contrast agents.
Nephron. Clinical practice 2006;103(2):c45-9.
2005: Regino Celeste Aida S; Torti Suzy V; Ma Rong; Yap Glenn P A; Kreisel Kevin A; Torti Frank M; Planalp Roy P; Brechbiel Martin W
N-picolyl derivatives of Kemp's triamine as potential antitumor agents: a preliminary investigation.
Journal of medicinal chemistry 2005;48(25):7993-9.
2005: Boswell C Andrew; Brechbiel Martin W
Auger electrons: lethal, low energy, and coming soon to a tumor cell nucleus near you.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(12):1946-7.
2005: Kobayashi Hisataka; Brechbiel Martin W
Nano-sized MRI contrast agents with dendrimer cores.
Advanced drug delivery reviews 2005;57(15):2271-86.
2005: Kobayashi Hisataka; Kawamoto Satomi; Brechbiel Martin W; Bernardo Marcelino; Sato Noriko; Waldmann Thomas A; Tagaya Yutaka; Choyke Peter L
Detection of lymph node involvement in hematologic malignancies using micromagnetic resonance lymphangiography with a gadolinum-labeled dendrimer nanoparticle.
Neoplasia (New York, N.Y.) 2005;7(11):984-91.
2005: Vallera Daniel A; Brechbiel Martin W; Burns Linda J; Panoskaltsis-Mortari Angela; Dusenbery Katie E; Clohisy Dennis R; Vitetta Ellen S
Radioimmunotherapy of CD22-expressing Daudi tumors in nude mice with a 90Y-labeled anti-CD22 monoclonal antibody.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(21):7920-8.
2005: Torti Suzy V; Ma Rong; Venditto Vincent J; Torti Frank M; Planalp Roy P; Brechbiel Martin W
Preliminary evaluation of the cytotoxicity of a series of tris-2-aminoethylamine (Tren) based hexadentate heterocyclic donor agents.
Bioorganic & medicinal chemistry 2005;13(21):5961-7.
2005: Turner Jolyn; Koumenis Constantinos; Kute Timothy E; Planalp Roy P; Brechbiel Martin W; Beardsley Dillon; Cody Brooke; Brown Kevin D; Torti Frank M; Torti Suzy V
Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation.
Blood 2005;106(9):3191-9.
2005: Milenic Diane E; Garmestani Kayhan; Brady Erik D; Albert Paul S; Ma Dangshe; Abdulla Alia; Brechbiel Martin W
Alpha-particle radioimmunotherapy of disseminated peritoneal disease using a (212)Pb-labeled radioimmunoconjugate targeting HER2.
Cancer biotherapy & radiopharmaceuticals 2005;20(5):557-68.
2005: Rogers Buck E; Roberson Peter L; Shen Sui; Khazaeli M B; Carpenter Mark; Yokoyama Shigeru; Brechbiel Martin W; LoBuglio Albert F; Buchsbaum Donald J
Intraperitoneal radioimmunotherapy with a humanized anti-TAG-72 (CC49) antibody with a deleted CH2 region.
Cancer biotherapy & radiopharmaceuticals 2005;20(5):502-13.
2005: Lee Fook T; Mountain Angela J; Kelly Marcus P; Hall Cathrine; Rigopoulos Angela; Johns Terrance G; Smyth Fiona E; Brechbiel Martin W; Nice Edouard C; Burgess Antony W; Scott Andrew M
Enhanced efficacy of radioimmunotherapy with 90Y-CHX-A''-DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(19 Pt 2):7080s-7086s.
2005: Qu Chang F; Songl Yan J; Rizvi Syed M A; Li Yong; Smith Ross; Perkins Alan C; Morgenstern Alfred; Brechbiel Martin; Allen Barry J
In vivo and in vitro inhibition of pancreatic cancer growth by targeted alpha therapy using 213Bi-CHX.A"-C595.
Cancer biology & therapy 2005;4(8):848-53.
2005: Vearing Christopher; Lee Fook-Thean; Wimmer-Kleikamp Sabine; Spirkoska Violeta; To Catherine; Stylianou Con; Spanevello Mark; Brechbiel Martin; Boyd Andrew W; Scott Andrew M; Lackmann Martin
Concurrent binding of anti-EphA3 antibody and ephrin-A5 amplifies EphA3 signaling and downstream responses: potential as EphA3-specific tumor-targeting reagents.
Cancer research 2005;65(15):6745-54.
2005: Venditto Vincent J; Regino Celeste Aida S; Brechbiel Martin W
PAMAM dendrimer based macromolecules as improved contrast agents.
Molecular pharmaceutics 2005;2(4):302-11.
2005: Sato Noriko; Hassan Raffit; Axworthy Donald B; Wong Karen J; Yu Sarah; Theodore Louis J; Lin Yukang; Park Luke; Brechbiel Martin W; Pastan Ira; Paik Chang H; Carrasquillo Jorge A
Pretargeted radioimmunotherapy of mesothelin-expressing cancer using a tetravalent single-chain Fv-streptavidin fusion protein.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(7):1201-9.
2005: Dear James W; Kobayashi Hisataka; Jo Sang-Kyung; Holly Mikaela K; Hu Xuzhen; Yuen Peter S T; Brechbiel Martin W; Star Robert A
Dendrimer-enhanced MRI as a diagnostic and prognostic biomarker of sepsis-induced acute renal failure in aged mice.
Kidney international 2005;67(6):2159-67.
2005: Garmestani Kayhan; Milenic Diane E; Brady Erik D; Plascjak Paul S; Brechbiel Martin W
Purification of cyclotron-produced 203Pb for labeling Herceptin.
Nuclear medicine and biology 2005;32(3):301-5.
2005: Panousis C; Rayzman V M; Johns T G; Renner C; Liu Z; Cartwright G; Lee F-T; Wang D; Gan H; Cao D; Kypridis A; Smyth F E; Brechbiel M W; Burgess A W; Old L J; Scott A M
Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR.
British journal of cancer 2005;92(6):1069-77.
2004: Milenic Diane E; Garmestani Kayhan; Brady Erik D; Albert Paul S; Ma Dangshe; Abdulla Alia; Brechbiel Martin W
Targeting of HER2 antigen for the treatment of disseminated peritoneal disease.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(23):7834-41.
2004: Kobayashi Hisataka; Brechbiel Martin W
Dendrimer-based nanosized MRI contrast agents.
Current pharmaceutical biotechnology 2004;5(6):539-49.
2004: Talanov Vladimir S; Yordanov Alexander T; Garmestani Kayhan; Milenic Diane E; Arora Hans C; Plascjak Paul S; Eckelman William C; Waldmann Thomas A; Brechbiel Martin W
Preparation and in vivo evaluation of novel linkers for 211At labeling of proteins.
Nuclear medicine and biology 2004;31(8):1061-71.
2004: Kobayashi Hisataka; Reijnders Koen; English Sean; Yordanov Alexander T; Milenic Diane E; Sowers Anastasia L; Citrin Deborah; Krishna Murali C; Waldmann Thomas A; Mitchell James B; Brechbiel Martin W
Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(22):7712-20.
2004: Chong Hyun-Soon; Torti Suzy V; Ma Rong; Torti Frank M; Brechbiel Martin W
Synthesis and potent antitumor activities of novel 1,3,5-cis,cis-triaminocyclohexane N-pyridyl derivatives.
Journal of medicinal chemistry 2004;47(21):5230-4.
2004: Camphausen Kevin; Sproull Mary; Tantama Steve; Venditto Vincent; Sankineni Sandeep; Scott Tamalee; Brechbiel Martin W
Evaluation of chelating agents as anti-angiogenic therapy through copper chelation.
Bioorganic & medicinal chemistry 2004;12(19):5133-40.
2004: Smart DeeDee K; Ortiz Karen L; Mattson David; Bradbury C Matthew; Bisht Kheem S; Sieck Leah K; Brechbiel Martin W; Gius David
Thioredoxin reductase as a potential molecular target for anticancer agents that induce oxidative stress.
Cancer research 2004;64(18):6716-24.
2004: Adams Gregory P; Shaller Calvin C; Dadachova Ekaterina; Simmons Heidi H; Horak Eva M; Tesfaye Abohawariat; Klein-Szanto Andres J P; Marks James D; Brechbiel Martin W; Weiner Louis M
A single treatment of yttrium-90-labeled CHX-A"-C6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice.
Cancer research 2004;64(17):6200-6.
2004: Wallner Paul E; Coleman C Norman; Brechbiel Martin; Milenic Diane; Tripuraneni Prabhakar
Are radiation oncologists serious about systemic radiation therapy and if not, should we be?
International journal of radiation oncology, biology, physics 2004;60(1):1-2.
2004: Kobayashi Hisataka; Jo Sang-Kyung; Kawamoto Satomi; Yasuda Hideo; Hu Xuzhen; Knopp Michael V; Brechbiel Martin W; Choyke Peter L; Star Robert A
Polyamine dendrimer-based MRI contrast agents for functional kidney imaging to diagnose acute renal failure.
Journal of magnetic resonance imaging : JMRI 2004;20(3):512-8.
2004: Bethge Wolfgang A; Wilbur D Scott; Storb Rainer; Hamlin Donald K; Santos Erlinda B; Brechbiel Martin W; Sandmaier Brenda M
Radioimmunotherapy with bismuth-213 as conditioning for nonmyeloablative allogeneic hematopoietic cell transplantation in dogs: a dose deescalation study.
Transplantation 2004;78(3):352-9.
2004: Zhang Meili; Zhang Zhuo; Garmestani Kayhan; Goldman Carolyn K; Ravetch Jeffrey V; Brechbiel Martin W; Carrasquillo Jorge A; Waldmann Thomas A
Activating Fc receptors are required for antitumor efficacy of the antibodies directed toward CD25 in a murine model of adult t-cell leukemia.
Cancer research 2004;64(16):5825-9.
2004: Brady Erik D; Chong Hyun-Soon; Milenic Diane E; Brechbiel Martin W
Development of a spectroscopic assay for bifunctional ligand-protein conjugates based on copper.
Nuclear medicine and biology 2004;31(6):795-802.
2004: Milenic Diane E; Brady Erik D; Brechbiel Martin W
Antibody-targeted radiation cancer therapy.
Nature reviews. Drug discovery 2004;3(6):488-99.
2004: Ye Neng; Park Gyungse; Przyborowska Ann M; Sloan Paula E; Clifford Thomas; Bauer Cary B; Broker Grant A; Rogers Robin D; Ma Rong; Torti Suzy V; Brechbiel Martin W; Planalp Roy P
Nickel(II), copper(II) and zinc(II) binding properties and cytotoxicity of tripodal, hexadentate tris(ethylenediamine)--analogue chelators.
Dalton transactions (Cambridge, England : 2003) 2004;(9):1304-11.
2004: Yao Zhengsheng; Zhang Meili; Garmestani Kayhan; Axworthy Donald B; Mallett Robert W; Fritzberg Alan R; Theodore Lou J; Plascjak Paul S; Eckelman William C; Waldmann Thomas A; Pastan Ira; Paik Chang H; Brechbiel Martin W; Carrasquillo Jorge A
Pretargeted alpha emitting radioimmunotherapy using (213)Bi 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid-biotin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):3137-46.
2004: Kobayashi Hisataka; Kawamoto Satomi; Sakai Yoshio; Choyke Peter L; Star Robert A; Brechbiel Martin W; Sato Noriko; Tagaya Yutaka; Morris John C; Waldmann Thomas A
Lymphatic drainage imaging of breast cancer in mice by micro-magnetic resonance lymphangiography using a nano-size paramagnetic contrast agent.
Journal of the National Cancer Institute 2004;96(9):703-8.
2004: Zhao Rong; Planalp Roy P; Ma Rong; Greene Bryan T; Jones Bradley T; Brechbiel Martin W; Torti Frank M; Torti Suzy V
Role of zinc and iron chelation in apoptosis mediated by tachpyridine, an anti-cancer iron chelator.
Biochemical pharmacology 2004;67(9):1677-88.
2004: Yao Zhengsheng; Dai Weili; Perry James; Brechbiel Martin W; Sung Cynthia
Effect of albumin fusion on the biodistribution of interleukin-2.
Cancer immunology, immunotherapy : CII 2004;53(5):404-10.
2004: Milenic Diane; Garmestani Kayhan; Dadachova Ekaterina; Chappell Lara; Albert Paul; Hill Donald; Schlom Jeffrey; Brechbiel Martin
Radioimmunotherapy of human colon carcinoma xenografts using a 213Bi-labeled domain-deleted humanized monoclonal antibody.
Cancer biotherapy & radiopharmaceuticals 2004;19(2):135-47.
2004: Kobayashi Hisataka; Kawamoto Satomi; Brechbiel Martin W; Jo Sang-Kyung; Hu Xuzhen; Yang Tianxin; Diwan Bhalchandra A; Waldmann Thomas A; Schnermann Jurgen; Choyke Peter L; Star Robert A
Micro-MRI methods to detect renal cysts in mice.
Kidney international 2004;65(4):1511-6.
2004: Wesley Jon N; McGee Edwin C; Garmestani Kayhan; Brechbiel Martin W; Yordanov Alexander T; Wu Chuanchu; Gansow Otto A; Eckelman William C; Bacher John D; Flynn Michael; Goldman Carolyn K; MacLin Melvin; Schwartz Uwe P; Jackson-White Terri; Phillip Celeste M; Decker Jean; Waldmann Thomas A
Systemic radioimmunotherapy using a monoclonal antibody, anti-Tac directed toward the alpha subunit of the IL-2 receptor armed with the alpha-emitting radionuclides (212)Bi or (211)At.
Nuclear medicine and biology 2004;31(3):357-64.
2004: Milenic Diane E; Brechbiel Martin W
Targeting of radio-isotopes for cancer therapy.
Cancer biology & therapy 2004;3(4):361-70.
2004: Vallera Daniel A; Elson Michael; Brechbiel Martin W; Dusenbery Kathryn E; Burns Linda J; Jaszcz Waclaw B; Ramsay Norma K; Panoskaltsis-Mortar Angela; Kuroki David W; Wagner John E; Vitetta Ellen S; Kersey John H
Radiotherapy of CD19 expressing Daudi tumors in nude mice with Yttrium-90-labeled anti-CD19 antibody.
Cancer biotherapy & radiopharmaceuticals 2004;19(1):11-23.
2004: Mamede Marcelo; Saga Tsuneo; Ishimori Takayoshi; Higashi Tatsuya; Sato Noriko; Kobayashi Hisataka; Brechbiel Martin W; Konishi Junji
Hepatocyte targeting of 111In-labeled oligo-DNA with avidin or avidin-dendrimer complex.
Journal of controlled release : official journal of the Controlled Release Society 2004;95(1):133-41.
2004: Mandler Raya; Kobayashi Hisataka; Hinson Ella R; Brechbiel Martin W; Waldmann Thomas A
Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity.
Cancer research 2004;64(4):1460-7.
2003: Bisht Kheem S; Bradbury C Matthew; Mattson David; Kaushal Aradhana; Sowers Anastasia; Markovina Stephanie; Ortiz Karen L; Sieck Leah K; Isaacs Jennifer S; Brechbiel Martin W; Mitchell James B; Neckers Leonard M; Gius David
Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.
Cancer research 2003;63(24):8984-95.
2003: Kobayashi Hisataka; Kawamoto Satomi; Choyke Peter L; Sato Noriko; Knopp Michael V; Star Robert A; Waldmann Thomas A; Tagaya Yutaka; Brechbiel Martin W
Comparison of dendrimer-based macromolecular contrast agents for dynamic micro-magnetic resonance lymphangiography.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2003;50(4):758-66.
2003: Wang Steven J; Brechbiel Martin; Wiener Erik C
Characteristics of a new MRI contrast agent prepared from polypropyleneimine dendrimers, generation 2.
Investigative radiology 2003;38(10):662-8.
2003: Michel Rosana B; Rosario Adriane V; Brechbiel Martin W; Jackson Thomas J; Goldenberg David M; Mattes M Jules
Experimental therapy of disseminated B-Cell lymphoma xenografts with 213Bi-labeled anti-CD74.
Nuclear medicine and biology 2003;30(7):715-23.
2003: Mamede Marcelo; Saga Tsuneo; Kobayashi Hisataka; Ishimori Takayoshi; Higashi Tatsuya; Sato Noriko; Brechbiel Martin W; Konishi Junji
Radiolabeling of avidin with very high specific activity for internal radiation therapy of intraperitoneally disseminated tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3756-62.
2003: Kobayashi Hisataka; Kawamoto Satomi; Star Robert A; Waldmann Thomas A; Brechbiel Martin W; Choyke Peter L
Activated clearance of a biotinylated macromolecular MRI contrast agent from the blood pool using an avidin chase.
Bioconjugate chemistry 2003;14(5):1044-7.
2003: Camphausen Kevin; Sproull Mary; Tantama Steve; Sankineni Sandeep; Scott Tamalee; Ménard Cynthia; Coleman C Norman; Brechbiel Martin W
Evaluation of copper chelation agents as anti-angiogenic therapy.
Bioorganic & medicinal chemistry 2003;11(19):4287-93.
2003: Chappell L L; Ma D; Milenic D E; Garmestani K; Venditto V; Beitzel M P; Brechbiel M W
Synthesis and evaluation of novel bifunctional chelating agents based on 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid for radiolabeling proteins.
Nuclear medicine and biology 2003;30(6):581-95.
2003: Mitchell Paul; Lee Fook-Thean; Hall Cathrine; Rigopoulos Angela; Smyth Fiona E; Hekman Anne-Marie; van Schijndel Gijs M; Powles Ray; Brechbiel Martin W; Scott Andrew M
Targeting primary human Ph(+) B-cell precursor leukemia-engrafted SCID mice using radiolabeled anti-CD19 monoclonal antibodies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(7):1105-12.
2003: Blend Michael J; Stastny Jerry J; Swanson Steven M; Brechbiel Martin W
Labeling anti-HER2/neu monoclonal antibodies with 111In and 90Y using a bifunctional DTPA chelating agent.
Cancer biotherapy & radiopharmaceuticals 2003;18(3):355-63.
2003: Sproull Mary; Brechbiel Martin; Camphausen Kevin
Antiangiogenic therapy through copper chelation.
Expert opinion on therapeutic targets 2003;7(3):405-9.
2003: Bethge Wolfgang A; Wilbur D Scott; Storb Rainer; Hamlin Donald K; Santos Erlinda B; Brechbiel Martin W; Fisher Darrell R; Sandmaier Brenda M
Selective T-cell ablation with bismuth-213-labeled anti-TCRalphabeta as nonmyeloablative conditioning for allogeneic canine marrow transplantation.
Blood 2003;101(12):5068-75.
2003: Vallera D A; Elson M; Brechbiel M W; Dusenbery K E; Burns L J; Skubitz K M; Jaszcz W B; Ramsay N K; Panoskaltsis-Mortari A; Kuroki D W; Wagner J E; Kersey J H
Preclinical studies targeting normal and leukemic hematopoietic cells with Yttrium-90-labeled anti-CD45 antibody in vitro and in vivo in nude mice.
Cancer biotherapy & radiopharmaceuticals 2003;18(2):133-45.
2003: Michel Rosana B; Brechbiel Martin W; Mattes M Jules
A comparison of 4 radionuclides conjugated to antibodies for single-cell kill.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(4):632-40.
2003: Nguyen Tung T; Pannu Yashdip S; Sung Cynthia; Dedrick Robert L; Walbridge Stuart; Brechbiel Martin W; Garmestani Kayhan; Beitzel Markus; Yordanov Alexander T; Oldfield Edward H
Convective distribution of macromolecules in the primate brain demonstrated using computerized tomography and magnetic resonance imaging.
Journal of neurosurgery 2003;98(3):584-90.
2003: Kobayashi Hisataka; Kawamoto Satomi; Jo Sang-Kyung; Bryant Henry L; Brechbiel Martin W; Star Robert A
Macromolecular MRI contrast agents with small dendrimers: pharmacokinetic differences between sizes and cores.
Bioconjugate chemistry 2003;14(2):388-94.
2003: Zhang Meili; Zhang Zhuo; Garmestani Kayhan; Schultz Jody; Axworthy Donald B; Goldman Carolyn K; Brechbiel Martin W; Carrasquillo Jorge A; Waldmann Thomas A
Pretarget radiotherapy with an anti-CD25 antibody-streptavidin fusion protein was effective in therapy of leukemia/lymphoma xenografts.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1891-5.
2003: Kobayashi Hisataka; Brechbiel Martin W
Dendrimer-based macromolecular MRI contrast agents: characteristics and application.
Molecular imaging : official journal of the Society for Molecular Imaging 2003;2(1):1-10.
2003: Kobayashi Hisataka; Kawamoto Satomi; Star Robert A; Waldmann Thomas A; Tagaya Yutaka; Brechbiel Martin W
Micro-magnetic resonance lymphangiography in mice using a novel dendrimer-based magnetic resonance imaging contrast agent.
Cancer research 2003;63(2):271-6.
2002: Chong Hyun-soon; Torti Frank M; Torti Suzy V; Brechbiel Martin W
Synthesis of 1,3,5-cis,cis-triaminocyclohexane N-pyridyl derivatives as potential antitumor agents.
The Journal of organic chemistry 2002;67(23):8072-8.
2002: Lonser Russell R; Walbridge Stuart; Garmestani Kayhan; Butman John A; Walters Hugh A; Vortmeyer Alexander O; Morrison Paul F; Brechbiel Martin W; Oldfield Edward H
Successful and safe perfusion of the primate brainstem: in vivo magnetic resonance imaging of macromolecular distribution during infusion.
Journal of neurosurgery 2002;97(4):905-13.
2002: Yao Zhengsheng; Zhang Meili; Axworthy Donald B; Wong Karen J; Garmestani Kayhan; Park Luke; Park Chang W; Mallett Robert W; Theodore Louis J; Yau Eric K; Waldmann Thomas A; Brechbiel Martin W; Paik Chang H; Pastan Ira; Carrasquillo Jorge A
Radioimmunotherapy of A431 xenografted mice with pretargeted B3 antibody-streptavidin and (90)Y-labeled 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA)-biotin.
Cancer research 2002;62(20):5755-60.
2002: Wilbur D Scott; Chyan Ming-Kuan; Hamlin Donald K; Kegley Brian B; Nilsson Rune; Sandberg Bengt E B; Brechbiel Martin
Trifunctional conjugation reagents. Reagents that contain a biotin and a radiometal chelation moiety for application to extracorporeal affinity adsorption of radiolabeled antibodies.
Bioconjugate chemistry 2002;13(5):1079-92.
2002: Planalp R P; Przyborowska A M; Park G; Ye N; Lu F H; Rogers R D; Broker G A; Torti S V; Brechbiel M W
Novel cytotoxic chelators that bind iron(II) selectively over zinc(II) under aqueous aerobic conditions.
Biochemical Society transactions 2002;30(4):758-62.
2002: Kobayashi Hisataka; Saga Tsuneo; Kawamoto Satomi; Sato Noriko; Hiraga Akira; Ishimori Takayoshi; Konishi Junji; Togashi Kaori; Brechbiel Martin W
Dynamic micro-MRI of liver micrometastasis with a novel liver macromolecular MR contrast agent DAB-Am64-(1B4M-Gd)64.
Academic radiology 2002;9 Suppl 2():S452-4.
2002: Wiener Erik C; Konda Sheela D; Wang Steven; Brechbiel Martin
Imaging folate binding protein expression with MRI.
Academic radiology 2002;9 Suppl 2():S316-9.
2002: Jurcic Joseph G; Larson Steven M; Sgouros George; McDevitt Michael R; Finn Ronald D; Divgi Chaitanya R; Ballangrud Ase M; Hamacher Klaus A; Ma Dangshe; Humm John L; Brechbiel Martin W; Molinet Roger; Scheinberg David A
Targeted alpha particle immunotherapy for myeloid leukemia.
Blood 2002;100(4):1233-9.
2002: Chong Hyun-soon; Garmestani Kayhan; Ma Dangshe; Milenic Diane E; Overstreet Terrish; Brechbiel Martin W
Synthesis and biological evaluation of novel macrocyclic ligands with pendent donor groups as potential yttrium chelators for radioimmunotherapy with improved complex formation kinetics.
Journal of medicinal chemistry 2002;45(16):3458-64.
2002: Mandler Raya; Kobayashi Hisataka; Davis Marie Y; Waldmann Thomas A; Brechbiel Martin W
Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates.
Bioconjugate chemistry 2002;13(4):786-91.
2002: Samuni Ayelet M; Krishna Murali C; DeGraff William; Russo Angelo; Planalp Roy P; Brechbiel Martin W; Mitchell James B
Mechanisms underlying the cytotoxic effects of Tachpyr--a novel metal chelator.
Biochimica et biophysica acta 2002;1571(3):211-8.
2002: Garmestani Kayhan; Milenic Diane E; Plascjak Paul S; Brechbiel Martin W
A new and convenient method for purification of 86Y using a Sr(II) selective resin and comparison of biodistribution of 86Y and 111In labeled Herceptin.
Nuclear medicine and biology 2002;29(5):599-606.
2002: Sandmaier Brenda M; Bethge Wolfgang A; Wilbur D Scott; Hamlin Donald K; Santos Erlinda B; Brechbiel Martin W; Fisher Darrell R; Storb Rainer
Bismuth 213-labeled anti-CD45 radioimmunoconjugate to condition dogs for nonmyeloablative allogeneic marrow grafts.
Blood 2002;100(1):318-26.
2002: Zhang Meili; Yao Zhengsheng; Garmestani Kayhan; Axworthy Donald B; Zhang Zhuo; Mallett Robert W; Theodore Louis J; Goldman Carolyn K; Brechbiel Martin W; Carrasquillo Jorge A; Waldmann Thomas A
Pretargeting radioimmunotherapy of a murine model of adult T-cell leukemia with the alpha-emitting radionuclide, bismuth 213.
Blood 2002;100(1):208-16.
2002: Greene Bryan T; Thorburn Jackie; Willingham Mark C; Thorburn Andrew; Planalp Roy P; Brechbiel Martin W; Jennings-Gee Jamie; Wilkinson John; Torti Frank M; Torti Suzy V
Activation of caspase pathways during iron chelator-mediated apoptosis.
The Journal of biological chemistry 2002;277(28):25568-75.
2002: Kobayashi Hisataka; Kawamoto Satomi; Jo Sang-Kyung; Sato Noriko; Saga Tsuneo; Hiraga Akira; Konishi Junji; Hu Susan; Togashi Kaori; Brechbiel Martin W; Star Robert A
Renal tubular damage detected by dynamic micro-MRI with a dendrimer-based magnetic resonance contrast agent.
Kidney international 2002;61(6):1980-5.
2002: Kennel S J; Mirzadeh S; Eckelman W C; Waldmann T A; Garmestani K; Yordanov A T; Stabin M G; Brechbiel M W
Vascular-targeted radioimmunotherapy with the alpha-particle emitter 211At.
Radiation research 2002;157(6):633-41.
2002: Milenic Diane E; Garmestani Kayhan; Chappell Lara L; Dadachova Ekaterina; Yordanov Alexander; Ma Dangshe; Schlom Jeffrey; Brechbiel Martin W
In vivo comparison of macrocyclic and acyclic ligands for radiolabeling of monoclonal antibodies with 177Lu for radioimmunotherapeutic applications.
Nuclear medicine and biology 2002;29(4):431-42.
2002: Yordanov Alexander T; Yamada Ken-ichi; Krishna Murali C; Russo Angelo; Yoo John; English Sean; Mitchell James B; Brechbiel Martin W
Acyl-protected hydroxylamines as spin label generators for EPR brain imaging.
Journal of medicinal chemistry 2002;45(11):2283-8.
2002: Kennel Stephen J; Brechbiel Martin W; Milenic Diane E; Schlom Jeffrey; Mirzadeh Saed
Actinium-225 conjugates of MAb CC49 and humanized delta CH2CC49.
Cancer biotherapy & radiopharmaceuticals 2002;17(2):219-31.
2002: Konda Sheela D; Wang Steven; Brechbiel Martin; Wiener Erik C
Biodistribution of a 153 Gd-folate dendrimer, generation = 4, in mice with folate-receptor positive and negative ovarian tumor xenografts.
Investigative radiology 2002;37(4):199-204.
2002: Aref Michael; Brechbiel Martin; Wiener Erik C
Identifying tumor vascular permeability heterogeneity with magnetic resonance imaging contrast agents.
Investigative radiology 2002;37(4):178-92.
2002: Eckelman William C; Frank Joseph A; Brechbiel Martin
Theory and practice of imaging saturable binding sites.
Investigative radiology 2002;37(3):101-6.
2002: Kobayashi Hisataka; Shirakawa Kazuo; Kawamoto Satomi; Saga Tsuneo; Sato Noriko; Hiraga Akira; Watanabe Ichiro; Heike Yuji; Togashi Kaori; Konishi Junji; Brechbiel Martin W; Wakasugi Hiro
Rapid accumulation and internalization of radiolabeled herceptin in an inflammatory breast cancer xenograft with vasculogenic mimicry predicted by the contrast-enhanced dynamic MRI with the macromolecular contrast agent G6-(1B4M-Gd)(256).
Cancer research 2002;62(3):860-6.
2002: Ma D; McDevitt M R; Barendswaard E; Lai L; Curcio M J; Pellegrini V; Brechbiel M W; Scheinberg D A
Radioimmunotherapy for model B cell malignancies using 90Y-labeled anti-CD19 and anti-CD20 monoclonal antibodies.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2002;16(1):60-6.
2002: Shirakawa Kazuo; Kobayashi Hisataka; Heike Yuji; Kawamoto Satomi; Brechbiel Martin W; Kasumi Fujio; Iwanaga Toshihiko; Konishi Fumio; Terada Masaaki; Wakasugi Hiro
Hemodynamics in vasculogenic mimicry and angiogenesis of inflammatory breast cancer xenograft.
Cancer research 2002;62(2):560-6.
2002: Ma Dangshe; Lu Francis; Overstreet Terrish; Milenic Diane E; Brechbiel Martin W
Novel chelating agents for potential clinical applications of copper.
Nuclear medicine and biology 2002;29(1):91-105.
2001: Kobayashi H; Kawamoto S; Saga T; Sato N; Hiraga A; Konishi J; Togashi K; Brechbiel M W
Micro-MR angiography of normal and intratumoral vessels in mice using dedicated intravascular MR contrast agents with high generation of polyamidoamine dendrimer core: reference to pharmacokinetic properties of dendrimer-based MR contrast agents.
Journal of magnetic resonance imaging : JMRI 2001;14(6):705-13.
2001: Sato N; Kobayashi H; Hiraga A; Saga T; Togashi K; Konishi J; Brechbiel M W
Pharmacokinetics and enhancement patterns of macromolecular MR contrast agents with various sizes of polyamidoamine dendrimer cores.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(6):1169-73.
2001: Sato N; Kobayashi H; Saga T; Nakamoto Y; Ishimori T; Togashi K; Fujibayashi Y; Konishi J; Brechbiel M W
Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(11):3606-12.
2001: Chong H S; Garmestani K; Bryant L H; Brechbiel M W
Synthesis of DTPA analogues derived from piperidine and azepane: potential contrast enhancement agents for magnetic resonance imaging.
The Journal of organic chemistry 2001;66(23):7745-50.
2001: Kobayashi H; Kawamoto S; Saga T; Sato N; Hiraga A; Ishimori T; Akita Y; Mamede M H; Konishi J; Togashi K; Brechbiel M W
Novel liver macromolecular MR contrast agent with a polypropylenimine diaminobutyl dendrimer core: comparison to the vascular MR contrast agent with the polyamidoamine dendrimer core.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(4):795-802.
2001: Kobayashi H; Kawamoto S; Saga T; Sato N; Hiraga A; Ishimori T; Konishi J; Togashi K; Brechbiel M W
Positive effects of polyethylene glycol conjugation to generation-4 polyamidoamine dendrimers as macromolecular MR contrast agents.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(4):781-8.
2001: Scott A M; Lee F T; Hopkins W; Cebon J S; Wheatley J M; Liu Z; Smyth F E; Murone C; Sturrock S; MacGregor D; Hanai N; Inoue K; Yamasaki M; Brechbiel M W; Davis I D; Murphy R; Hannah A; Lim-Joon M; Chan T; Chong G; Ritter G; Hoffman E W; Burgess A W; Old L J
Specific targeting, biodistribution, and lack of immunogenicity of chimeric anti-GD3 monoclonal antibody KM871 in patients with metastatic melanoma: results of a phase I trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(19):3976-87.
2001: Yordanov A T; Garmestani K; Zhang M; Zhang Z; Yao Z; Phillips K E; Herring B; Horak E; Beitzel M P; Schwarz U P; Gansow O A; Plascjak P S; Eckelman W C; Waldmann T A; Brechbiel M W
Preparation and in vivo evaluation of linkers for 211At labeling of humanized anti-Tac.
Nuclear medicine and biology 2001;28(7):845-56.
2001: Abeysinghe R D; Greene B T; Haynes R; Willingham M C; Turner J; Planalp R P; Brechbiel M W; Torti F M; Torti S V
p53-independent apoptosis mediated by tachpyridine, an anti-cancer iron chelator.
Carcinogenesis 2001;22(10):1607-14.
2001: Kobayashi H; Sato N; Kawamoto S; Saga T; Hiraga A; Ishimori T; Konishi J; Togashi K; Brechbiel M W
3D MR angiography of intratumoral vasculature using a novel macromolecular MR contrast agent.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(3):579-85.
2001: Kobayashi H; Sato N; Kawamoto S; Saga T; Hiraga A; Ishimori T; Konishi J; Togashi K; Brechbiel M W
Novel intravascular macromolecular MRI contrast agent with generation-4 polyamidoamine dendrimer core: accelerated renal excretion with coinjection of lysine.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(3):457-64.
2001: Dadachova E; Park C; Eberly N; Ma D; Paik C H; Brechbiel M W
In vitro and in vivo characterization of 67Ga(3+) complexes with cis,cis-1,3,5-triamino-cyclohexane-N,N',N"-triacetic acid derivatives.
Nuclear medicine and biology 2001;28(6):695-701.
2001: Deal K A; Park G; Shao J; Chasteen N D; Brechbiel M W; Planalp R P
Copper(II) complexes of novel N-alkylated derivatives of cis,cis-1,3,5-triaminocyclohexane. 2. Metal-promoted phosphate diester hydrolysis.
Inorganic chemistry 2001;40(17):4176-82.
2001: Park G; Shao J; Lu F H; Rogers R D; Chasteen N D; Brechbiel M W; Planalp R P
Copper(II) complexes of novel N-alkylated derivatives of cis,cis-1,3,5-triaminocyclohexane. 1. Preparation and structure.
Inorganic chemistry 2001;40(17):4167-75.
2001: Lövqvist A; Humm J L; Sheikh A; Finn R D; Koziorowski J; Ruan S; Pentlow K S; Jungbluth A; Welt S; Lee F T; Brechbiel M W; Larson S M
PET imaging of (86)Y-labeled anti-Lewis Y monoclonal antibodies in a nude mouse model: comparison between (86)Y and (111)In radiolabels.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2001;42(8):1281-7.
2001: Hassfjell S; Brechbiel M W
The development of the alpha-particle emitting radionuclides 212Bi and 213Bi, and their decay chain related radionuclides, for therapeutic applications.
Chemical reviews 2001;101(7):2019-36.
2001: Kobayashi H; Kawamoto S; Saga T; Sato N; Ishimori T; Konishi J; Ono K; Togashi K; Brechbiel M W
Avidin-dendrimer-(1B4M-Gd)(254): a tumor-targeting therapeutic agent for gadolinium neutron capture therapy of intraperitoneal disseminated tumor which can be monitored by MRI.
Bioconjugate chemistry 2001;12(4):587-93.
2001: Brechbiel M W
Chelated metal ions for therapeutic and diagnostic applications.
Experimental biology and medicine (Maywood, N.J.) 2001;226(7):627-8.
2001: Kobayashi H; Saga T; Kawamoto S; Sato N; Hiraga A; Ishimori T; Konishi J; Togashi K; Brechbiel M W
Dynamic micro-magnetic resonance imaging of liver micrometastasis in mice with a novel liver macromolecular magnetic resonance contrast agent DAB-Am64-(1B4M-Gd)(64).
Cancer research 2001;61(13):4966-70.
2001: Lee F T; Rigopoulos A; Hall C; Clarke K; Cody S H; Smyth F E; Liu Z; Brechbiel M W; Hanai N; Nice E C; Catimel B; Burgess A W; Welt S; Ritter G; Old L J; Scott A M
Specific localization, gamma camera imaging, and intracellular trafficking of radiolabelled chimeric anti-G(D3) ganglioside monoclonal antibody KM871 in SK-MEL-28 melanoma xenografts.
Cancer research 2001;61(11):4474-82.
2001: Garmestani K; Yao Z; Zhang M; Wong K; Park C W; Pastan I; Carrasquillo J A; Brechbiel M W
Synthesis and evaluation of a macrocyclic bifunctional chelating agent for use with bismuth radionuclides.
Nuclear medicine and biology 2001;28(4):409-18.
2001: Konda S D; Aref M; Wang S; Brechbiel M; Wiener E C
Specific targeting of folate-dendrimer MRI contrast agents to the high affinity folate receptor expressed in ovarian tumor xenografts.
Magma (New York, N.Y.) 2001;12(2-3):104-13.
2001: Renner C; Stehle I; Lee F T; Hall C; Catimel B; Nice E C; Mountain A; Rigopoulos A; Brechbiel M W; Pfreundschuh M; Scott A M
Targeting properties of an anti-CD16/anti-CD30 bispecific antibody in an in vivo system.
Cancer immunology, immunotherapy : CII 2001;50(2):102-8.
2001: Milenic D E; Roselli M; Mirzadeh S; Pippin C G; Gansow O A; Colcher D; Brechbiel M W; Schlom J
In vivo evaluation of bismuth-labeled monoclonal antibody comparing DTPA-derived bifunctional chelates.
Cancer biotherapy & radiopharmaceuticals 2001;16(2):133-46.
2001: Tahtis K; Lee F T; Smyth F E; Power B E; Renner C; Brechbiel M W; Old L J; Hudson P J; Scott A M
Biodistribution properties of (111)indium-labeled C-functionalized trans-cyclohexyl diethylenetriaminepentaacetic acid humanized 3S193 diabody and F(ab')(2) constructs in a breast carcinoma xenograft model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(4):1061-72.
2001: Kobayashi H; Sato N; Hiraga A; Saga T; Nakamoto Y; Ueda H; Konishi J; Togashi K; Brechbiel M W
3D-micro-MR angiography of mice using macromolecular MR contrast agents with polyamidoamine dendrimer core with reference to their pharmacokinetic properties.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;45(3):454-60.
2001: Luo H; Eberly N; Rogers R D; Brechbiel M W
Syntheses and characterizations of metal complexes derived from cis,cis-1,3,5-triaminocyclohexane-N,N',N"-triacetic acid.
Inorganic chemistry 2001;40(3):493-8.
2001: Kobayashi H; Sato N; Kawamoto S; Saga T; Hiraga A; Haque T L; Ishimori T; Konishi J; Togashi K; Brechbiel M W
Comparison of the macromolecular MR contrast agents with ethylenediamine-core versus ammonia-core generation-6 polyamidoamine dendrimer.
Bioconjugate chemistry 2001;12(1):100-7.
2001: Samuni A M; Afeworki M; Stein W; Yordanov A T; DeGraff W; Krishna M C; Mitchell J B; Brechbiel M W
Multifunctional antioxidant activity of HBED iron chelator.
Free radical biology & medicine 2001;30(2):170-7.
2000: Kennel S J; Mirzadeh S; Hurst G B; Foote L J; Lankford T K; Glowienka K A; Chappell L L; Kelso J R; Davern S M; Safavy A; Brechbiel M W
Labeling and distribution of linear peptides identified using in vivo phage display selection for tumors.
Nuclear medicine and biology 2000;27(8):815-25.
2000: McDevitt M R; Barendswaard E; Ma D; Lai L; Curcio M J; Sgouros G; Ballangrud A M; Yang W H; Finn R D; Pellegrini V; Geerlings M W; Lee M; Brechbiel M W; Bander N H; Cordon-Cardo C; Scheinberg D A
An alpha-particle emitting antibody ([213Bi]J591) for radioimmunotherapy of prostate cancer.
Cancer research 2000;60(21):6095-100.
2000: Mandler R; Wu C; Sausville E A; Roettinger A J; Newman D J; Ho D K; King C R; Yang D; Lippman M E; Landolfi N F; Dadachova E; Brechbiel M W; Waldmann T A
Immunoconjugates of geldanamycin and anti-HER2 monoclonal antibodies: antiproliferative activity on human breast carcinoma cell lines.
Journal of the National Cancer Institute 2000;92(19):1573-81.
2000: Kobayashi H; Sato N; Saga T; Nakamoto Y; Ishimori T; Toyama S; Togashi K; Konishi J; Brechbiel M W
Monoclonal antibody-dendrimer conjugates enable radiolabeling of antibody with markedly high specific activity with minimal loss of immunoreactivity.
European journal of nuclear medicine 2000;27(9):1334-9.
2000: Clarke K; Lee F T; Brechbiel M W; Smyth F E; Old L J; Scott A M
Therapeutic efficacy of anti-Lewis(y) humanized 3S193 radioimmunotherapy in a breast cancer model: enhanced activity when combined with taxol chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(9):3621-8.
2000: Clarke K; Lee F T; Brechbiel M W; Smyth F E; Old L J; Scott A M
In vivo biodistribution of a humanized anti-Lewis Y monoclonal antibody (hu3S193) in MCF-7 xenografted BALB/c nude mice.
Cancer research 2000;60(17):4804-11.
2000: Chappell L L; Deal K A; Dadachova E; Brechbiel M W
Synthesis, conjugation, and radiolabeling of a novel bifunctional chelating agent for (225)Ac radioimmunotherapy applications.
Bioconjugate chemistry 2000;11(4):510-9.
2000: Kennel S J; Chappell L L; Dadachova K; Brechbiel M W; Lankford T K; Davis I A; Stabin M; Mirzadeh S
Evaluation of 225Ac for vascular targeted radioimmunotherapy of lung tumors.
Cancer biotherapy & radiopharmaceuticals 2000;15(3):235-44.
2000: Adams G P; Shaller C C; Chappell L L; Wu C; Horak E M; Simmons H H; Litwin S; Marks J D; Weiner L M; Brechbiel M W
Delivery of the alpha-emitting radioisotope bismuth-213 to solid tumors via single-chain Fv and diabody molecules.
Nuclear medicine and biology 2000;27(4):339-46.
2000: Mandler R; Dadachova E; Brechbiel J K; Waldmann T A; Brechbiel M W
Synthesis and evaluation of antiproliferative activity of a geldanamycin-Herceptin immunoconjugate.
Bioorganic & medicinal chemistry letters 2000;10(10):1025-8.
2000: Pai-Scherf L H; Carrasquillo J A; Paik C; Gansow O; Whatley M; Pearson D; Webber K; Hamilton M; Allegra C; Brechbiel M; Willingham M C; Pastan I
Imaging and phase I study of 111In- and 90Y-labeled anti-LewisY monoclonal antibody B3.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1720-30.
2000: Kobayashi H; Kao C H; Kreitman R J; Le N; Kim M K; Brechbiel M W; Paik C H; Pastan I; Carrasquillo J A
Pharmacokinetics of 111In- and 125I-labeled antiTac single-chain Fv recombinant immunotoxin.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2000;41(4):755-62.
2000: Chappell L L; Dadachova E; Milenic D E; Garmestani K; Wu C; Brechbiel M W
Synthesis, characterization, and evaluation of a novel bifunctional chelating agent for the lead isotopes 203Pb and 212Pb.
Nuclear medicine and biology 2000;27(1):93-100.
2000: Konda S D; Aref M; Brechbiel M; Wiener E C
Development of a tumor-targeting MR contrast agent using the high-affinity folate receptor: work in progress.
Investigative radiology 2000;35(1):50-7.
1999: Dadachova E; Chappell L L; Brechbiel M W
Spectrophotometric method for determination of bifunctional macrocyclic ligands in macrocyclic ligand-protein conjugates.
Nuclear medicine and biology 1999;26(8):977-82.
1999: Chappell L L; Rogers B E; Khazaeli M B; Mayo M S; Buchsbaum D J; Brechbiel M W
Improved synthesis of the bifunctional chelating agent 1,4,7,10-tetraaza-N-(1-carboxy-3-(4-nitrophenyl)propyl)-N',N'',N'''-tri s(acetic acid)cyclododecane (PA-DOTA).
Bioorganic & medicinal chemistry 1999;7(11):2313-20.
1999: Buchsbaum D J; Rogers B E; Khazaeli M B; Mayo M S; Milenic D E; Kashmiri S V; Anderson C J; Chappell L L; Brechbiel M W; Curiel D T
Targeting strategies for cancer radiotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(10 Suppl):3048s-3055s.
1999: Davis I A; Glowienka K A; Boll R A; Deal K A; Brechbiel M W; Stabin M; Bochsler P N; Mirzadeh S; Kennel S J
Comparison of 225actinium chelates: tissue distribution and radiotoxicity.
Nuclear medicine and biology 1999;26(5):581-9.
1999: Deal K A; Davis I A; Mirzadeh S; Kennel S J; Brechbiel M W
Improved in vivo stability of actinium-225 macrocyclic complexes.
Journal of medicinal chemistry 1999;42(15):2988-92.
1999: Roselli M; Milenic D E; Brechbiel M W; Mirzadeh S; Pippin C G; Gansow O A; Colcher D; Schlom J
In vivo comparison of CHX-DTPA ligand isomers in athymic mice bearing carcinoma xenografts.
Cancer biotherapy & radiopharmaceuticals 1999;14(3):209-20.
1999: Wu C; Gansow O A; Brechbiel M W
Evaluation of methods for large scale preparation of antibody ligand conjugates.
Nuclear medicine and biology 1999;26(3):339-42.
1999: Bryant L H; Brechbiel M W; Wu C; Bulte J W; Herynek V; Frank J A
Synthesis and relaxometry of high-generation (G = 5, 7, 9, and 10) PAMAM dendrimer-DOTA-gadolinium chelates.
Journal of magnetic resonance imaging : JMRI 1999;9(2):348-52.
1999: Carrasquillo J A; White J D; Paik C H; Raubitschek A; Le N; Rotman M; Brechbiel M W; Gansow O A; Top L E; Perentesis P; Reynolds J C; Nelson D L; Waldmann T A
Similarities and differences in 111In- and 90Y-labeled 1B4M-DTPA antiTac monoclonal antibody distribution.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1999;40(2):268-76.
1999: Kennel S J; Stabin M; Yoriyaz H; Brechbiel M; Mirzadeh S
Treatment of lung tumor colonies with 90Y targeted to blood vessels: comparison with the alpha-particle emitter 213Bi.
Nuclear medicine and biology 1999;26(1):149-57.
1999: Nikula T K; McDevitt M R; Finn R D; Wu C; Kozak R W; Garmestani K; Brechbiel M W; Curcio M J; Pippin C G; Tiffany-Jones L; Geerlings M W; Apostolidis C; Molinet R; Geerlings M W; Gansow O A; Scheinberg D A
Alpha-emitting bismuth cyclohexylbenzyl DTPA constructs of recombinant humanized anti-CD33 antibodies: pharmacokinetics, bioactivity, toxicity and chemistry.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1999;40(1):166-76.
1999: Kobayashi H; Wu C; Kim M K; Paik C H; Carrasquillo J A; Brechbiel M W
Evaluation of the in vivo biodistribution of indium-111 and yttrium-88 labeled dendrimer-1B4M-DTPA and its conjugation with anti-Tac monoclonal antibody.
Bioconjugate chemistry 1999;10(1):103-11.
1998: Bulte J W; Wu C; Brechbiel M W; Brooks R A; Vymazal J; Holla M; Frank J A
Dysprosium-DOTA-PAMAM dendrimers as macromolecular T2 contrast agents. Preparation and relaxometry.
Investigative radiology 1998;33(11):841-5.
1998: McMurry T J; Pippin C G; Wu C; Deal K A; Brechbiel M W; Mirzadeh S; Gansow O A
Physical parameters and biological stability of yttrium(III) diethylenetriaminepentaacetic acid derivative conjugates.
Journal of medicinal chemistry 1998;41(18):3546-9.
1998: Torti S V; Torti F M; Whitman S P; Brechbiel M W; Park G; Planalp R P
Tumor cell cytotoxicity of a novel metal chelator.
Blood 1998;92(4):1384-9.
1998: Kobayashi H; Wu C; Yoo T M; Sun B F; Drumm D; Pastan I; Paik C H; Gansow O A; Carrasquillo J A; Brechbiel M W
Evaluation of the in vivo biodistribution of yttrium-labeled isomers of CHX-DTPA-conjugated monoclonal antibodies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1998;39(5):829-36.
1998: Milenic D E; Roselli M; Brechbiel M W; Pippin C G; McMurray T J; Carrasquillo J A; Colcher D; Lambrecht R; Gansow O A; Schlom J
In vivo evaluation of a lead-labeled monoclonal antibody using the DOTA ligand.
European journal of nuclear medicine 1998;25(5):471-80.
1997: Horak E; Hartmann F; Garmestani K; Wu C; Brechbiel M; Gansow O A; Landolfi N F; Waldmann T A
Radioimmunotherapy targeting of HER2/neu oncoprotein on ovarian tumor using lead-212-DOTA-AE1.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1997;38(12):1944-50.
1997: Wiener E C; Konda S; Shadron A; Brechbiel M; Gansow O
Targeting dendrimer-chelates to tumors and tumor cells expressing the high-affinity folate receptor.
Investigative radiology 1997;32(12):748-54.
1997: Wu C; Kobayashi H; Sun B; Yoo T M; Paik C H; Gansow O A; Carrasquillo J A; Pastan I; Brechbiel M W
Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p-nitrobenzyl)-trans-CyDTPA.
Bioorganic & medicinal chemistry 1997;5(10):1925-34.
1997: Lang L; Jagoda E; Wu C; Brechbiel M W; Gansow O A; Pastan I; Paik C H; Carrasquillo J A; Eckelman W C
Factors influencing the in vivo pharmacokinetics of peptides and antibody fragments: the pharmacokinetics of two PET-labeled low molecular weight proteins.
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) 1997;41(2):53-61.
1997: Brechbiel M W; Beitzel P M; Gansow O A
Purification of p-nitrobenzyl C-functionalized diethylenetriamine pentaacetic acids for clinical applications using anion-exchange chromatography.
Journal of chromatography. A 1997;771(1-2):63-9.
1997: Wu C; Jagoda E; Brechbiel M; Webber K O; Pastan I; Gansow O; Eckelman W C
Biodistribution and catabolism of Ga-67-labeled anti-Tac dsFv fragment.
Bioconjugate chemistry 1997;8(3):365-9.
1997: Lee J; Garmestani K; Wu C; Brechbiel M W; Chang H K; Choi C W; Gansow O A; Carrasquillo J A; Paik C H
In vitro and in vivo evaluation of structure-stability relationship of 111In- and 67Ga-labeled antibody via 1B4M or C-NOTA chelates.
Nuclear medicine and biology 1997;24(3):225-30.
1995: Waldmann T A; White J D; Carrasquillo J A; Reynolds J C; Paik C H; Gansow O A; Brechbiel M W; Jaffe E S; Fleisher T A; Goldman C K; Top L E; Bamford R; Zaknoen E; Roessler E; Kasten-Sportes C; England R; Litou H; Johnson J A; Jackson-White T; Manns A; Hanchard B; Junghans R P; Nelson D L
Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac.
Blood 1995;86(11):4063-75.
1995: Nikula T K; Curcio M J; Brechbiel M W; Gansow O A; Finn R D; Scheinberg D A
A rapid, single vessel method for preparation of clinical grade ligand conjugated monoclonal antibodies.
Nuclear medicine and biology 1995;22(3):387-90.
1994: Kinuya S; Jeong J M; Garmestani K; Saga T; Camera L; Brechbiel M W; Gansow O A; Carrasquillo J A; Neumann R D; Paik C H
Effect of metabolism on retention of indium-111-labeled monoclonal antibody in liver and blood.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1994;35(11):1851-7.
1994: Hartmann F; Horak E M; Garmestani K; Wu C; Brechbiel M W; Kozak R W; Tso J; Kosteiny S A; Gansow O A; Nelson D L
Radioimmunotherapy of nude mice bearing a human interleukin 2 receptor alpha-expressing lymphoma utilizing the alpha-emitting radionuclide-conjugated monoclonal antibody 212Bi-anti-Tac.
Cancer research 1994;54(16):4362-70.
1994: Camera L; Kinuya S; Garmestani K; Brechbiel M W; Wu C; Pai L H; McMurry T J; Gansow O A; Pastan I; Paik C H
Comparative biodistribution of indium- and yttrium-labeled B3 monoclonal antibody conjugated to either 2-(p-SCN-Bz)-6-methyl-DTPA (1B4M-DTPA) or 2-(p-SCN-Bz)-1,4,7,10-tetraazacyclododecane tetraacetic acid (2B-DOTA).
European journal of nuclear medicine 1994;21(7):640-6.
1994: Camera L; Kinuya S; Garmestani K; Wu C; Brechbiel M W; Pai L H; McMurry T J; Gansow O A; Pastan I; Paik C H
Evaluation of the serum stability and in vivo biodistribution of CHX-DTPA and other ligands for yttrium labeling of monoclonal antibodies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1994;35(5):882-9.
1994: Wiener E C; Brechbiel M W; Brothers H; Magin R L; Gansow O A; Tomalia D A; Lauterbur P C
Dendrimer-based metal chelates: a new class of magnetic resonance imaging contrast agents.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1994;31(1):1-8.
1993: Junghans R P; Dobbs D; Brechbiel M W; Mirzadeh S; Raubitschek A A; Gansow O A; Waldmann T A
Pharmacokinetics and bioactivity of 1,4,7,10-tetra-azacylododecane off',N'',N'''-tetraacetic acid (DOTA)-bismuth-conjugated anti-Tac antibody for alpha-emitter (212Bi) therapy.
Cancer research 1993;53(23):5683-9.
1993: Camera L; Kinuya S; Garmestani K; Pai L H; Brechbiel M W; Gansow O A; Paik C H; Pastan I; Carrasquillo J A
Evaluation of a new DTPA-derivative chelator: comparative biodistribution and imaging studies of 111In-labeled B3 monoclonal antibody in athymic mice bearing human epidermoid carcinoma xenografts.
Nuclear medicine and biology 1993;20(8):955-62.
1993: Camera L; Kinuya S; Pai L H; Garmestani K; Brechbiel M W; Gansow O A; Paik C H; Pastan I; Carrasquillo J A
Preclinical evaluation of 111In-labeled B3 monoclonal antibody: biodistribution and imaging studies in nude mice bearing human epidermoid carcinoma xenografts.
Cancer research 1993;53(12):2834-9.
1993: McMurry T J; Brechbiel M; Wu C; Gansow O A
Synthesis of 2-(p-thiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid: application of the 4-methoxy-2,3,6-trimethylbenzenesulfonamide protecting group in the synthesis of macrocyclic polyamines.
Bioconjugate chemistry 1993;4(3):236-45.
1992: Parenteau G L; Dirbas F M; Garmestani K; Brechbiel M W; Bukowski M A; Goldman C K; Clark R; Gansow O A; Waldmann T A
Prolongation of graft survival in primate allograft transplantation by yttrium-90-labeled anti-Tac in conjunction with granulocyte colony-stimulating factor.
Transplantation 1992;54(6):963-8.
1992: Huneke R B; Pippin C G; Squire R A; Brechbiel M W; Gansow O A; Strand M
Effective alpha-particle-mediated radioimmunotherapy of murine leukemia.
Cancer research 1992;52(20):5818-20.
1992: Pippin C G; Parker T A; McMurry T J; Brechbiel M W
Spectrophotometric method for the determination of a bifunctional DTPA ligand in DTPA-monoclonal antibody conjugates.
Bioconjugate chemistry 1992;3(4):342-5.
1992: McMurry T J; Brechbiel M; Kumar K; Gansow O A
Convenient synthesis of bifunctional tetraaza macrocycles.
Bioconjugate chemistry 1992;3(2):108-17.
1991: Brechbiel M W; Gansow O A
Backbone-substituted DTPA ligands for 90Y radioimmunotherapy.
Bioconjugate chemistry 1991;2(3):187-94.
1991: Roselli M; Schlom J; Gansow O A; Brechbiel M W; Mirzadeh S; Pippin C G; Milenic D E; Colcher D
Comparative biodistribution studies of DTPA-derivative bifunctional chelates for radiometal labeled monoclonal antibodies.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1991;18(4):389-94.
1990: Cooper M M; Robbins R C; Goldman C K; Mirzadeh S; Brechbiel M W; Stone C D; Gansow O A; Clark R E; Waldmann T A
Use of yttrium-90-labeled anti-Tac antibody in primate xenograft transplantation.
Transplantation 1990;50(5):760-5.
1990: Langmuir V K; Atcher R W; Hines J J; Brechbiel M W
Iodine-125-NRLU-10 kinetic studies and bismuth-212-NRLU-10 toxicity in LS174T multicell spheroids.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1990;31(9):1527-33.
1990: Greager J A; Chao T C; Blend M J; Atcher R W; Gansow O A; Brechbiel M W; Das Gupta T K
Localization of pulmonary human sarcoma xenografts in athymic nude mice with indium-111-labeled monoclonal antibodies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1990;31(8):1378-83.
1990: Ruegg C L; Anderson-Berg W T; Brechbiel M W; Mirzadeh S; Gansow O A; Strand M
Improved in vivo stability and tumor targeting of bismuth-labeled antibody.
Cancer research 1990;50(14):4221-6.
1990: Khaw B A; Gansow O; Brechbiel M W; O'Donnell S M; Nossiff N
Use of isothiocyanatobenzyl-DTPA derivatized monoclonal antimyosin fab for enhanced in vivo target localization.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1990;31(2):211-7.
1990: Mirzadeh S; Brechbiel M W; Atcher R W; Gansow O A
Radiometal labeling of immunoproteins: covalent linkage of 2-(4-isothiocyanatobenzyl)diethylenetriaminepentaacetic acid ligands to immunoglobulin.
Bioconjugate chemistry 1990;1(1):59-65.
1989: Roselli M; Schlom J; Gansow O A; Raubitschek A; Mirzadeh S; Brechbiel M W; Colcher D
Comparative biodistributions of yttrium- and indium-labeled monoclonal antibody B72.3 in athymic mice bearing human colon carcinoma xenografts.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1989;30(5):672-82.
1989: Kozak R W; Raubitschek A; Mirzadeh S; Brechbiel M W; Junghans R P; Gansow O A; Waldmann T A;
Nature of the bifunctional chelating agent used for radioimmunotherapy with yttrium-90 monoclonal antibodies: critical factors in determining in vivo survival and organ toxicity.
Cancer research 1989;49(10):2639-44.
1988: Blend M J; Greager J A; Atcher R W; Brown J M; Brechbiel M W; Gansow O A; Das Gupta T K
Improved sarcoma imaging and reduced hepatic activity with indium-111-SCN-Bz-DTPA linked to MoAb 19-24.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1988;29(11):1810-6.
1988: Kurtzman S H; Russo A; Mitchell J B; DeGraff W; Sindelar W F; Brechbiel M W; Gansow O A; Friedman A M; Hines J J; Gamson J
212Bismuth linked to an antipancreatic carcinoma antibody: model for alpha-particle-emitter radioimmunotherapy.
Journal of the National Cancer Institute 1988;80(6):449-52.
1987: Esteban J M; Schlom J; Gansow O A; Atcher R W; Brechbiel M W; Simpson D E; Colcher D
New method for the chelation of indium-111 to monoclonal antibodies: biodistribution and imaging of athymic mice bearing human colon carcinoma xenografts.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1987;28(5):861-70.
1987: Knop R H; Frank J A; Dwyer A J; Girton M E; Naegele M; Schrader M; Cobb J; Gansow O; Maegerstadt M; Brechbiel M
Gadolinium cryptelates as MR contrast agents.
Journal of computer assisted tomography 1987;11(1):35-42.
1986: Frank J A; Dwyer A J; Girton M; Knop R H; Sank V J; Gansow O A; Magerstadt M; Brechbiel M; Doppman J L
Opening of blood-ocular barrier demonstrated by contrast-enhanced MR imaging.
Journal of computer assisted tomography 1986;10(6):912-6.
1986: Magerstädt M; Gansow O A; Brechbiel M W; Colcher D; Baltzer L; Knop R H; Girton M E; Naegele M
Gd(DOTA): an alternative to Gd(DTPA) as a T1,2 relaxation agent for NMR imaging or spectroscopy.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1986;3(5):808-12.

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