FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

REGISTER

now for free

Martin Brechbiel

Research Profile

Living Beings

Chemicals & Drugs

Procedures

Concepts & Ideas

Anatomy

Tumor Cell Line

Register to see full profile

Co-author Network

Register to see all co-authors

Publications

TOP 3
Tapan K Nayak; Marcelino Bernardo; Peter L Choyke; Diane E Milenic; Martin W Brechbiel
Orthotopic pleural mesothelioma in mice: SPECT/CT and MR imaging with HER1- and HER2-targeted radiolabeled antibodies.
Kwon Joong Yong; Diane E Milenic; Kwamena Baidoo; Martin W Brechbiel
Sensitization of tumor to ²¹²Pb radioimmunotherapy by gemcitabine involves initial abrogation of G2 arrest and blocked DNA damage repair by interference with Rad51.
François Guérard; Yong-Sok Lee; Lawrence P Szajek; Raphaël Tripier; Jeffrey R Deschamps; Martin W Brechbiel
Investigation of Zr(IV) and 89Zr(IV) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging.

Register to see all publications

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Register to see more

Geonetwork of Martin Brechbiel (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Register to see more

All Publications

2013: Tapan K Nayak; Marcelino Bernardo; Peter L Choyke; Diane E Milenic; Martin W Brechbiel
Orthotopic pleural mesothelioma in mice: SPECT/CT and MR imaging with HER1- and HER2-targeted radiolabeled antibodies.
Radiology 2013;267(1):173-82.
2013: Kwon Joong Yong; Diane E Milenic; Kwamena Baidoo; Martin W Brechbiel
Sensitization of tumor to ²¹²Pb radioimmunotherapy by gemcitabine involves initial abrogation of G2 arrest and blocked DNA damage repair by interference with Rad51.
International journal of radiation oncology, biology, physics 2013;85(4):1119-26.
2013: François Guérard; Yong-Sok Lee; Lawrence P Szajek; Raphaël Tripier; Jeffrey R Deschamps; Martin W Brechbiel
Investigation of Zr(IV) and 89Zr(IV) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging.
Chemical communications (Cambridge, England) 2013;49(10):1002-4.
2013: Kwamena Baidoo; Kwon Yong; Martin W Brechbiel
Molecular pathways: targeted α-particle radiation therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(3):530-7.
2013: François Guérard; Jean-François Gestin; Martin W Brechbiel
Production of [(211)At]-astatinated radiopharmaceuticals and applications in targeted α-particle therapy.
Cancer biotherapy & radiopharmaceuticals 2013;28(1):1-20.
2012: Ching-Hui Huang; Kido Nwe; Ajlan Al Zaki; Martin W Brechbiel; Andrew Tsourkas
Biodegradable polydisulfide dendrimer nanoclusters as MRI contrast agents.
ACS nano 2012;6(11):9416-24.
2012: Young-Seung Kim; Diane E Milenic; Kido Nwe; Stanley Satz; Martin W Brechbiel; Kwamena Baidoo
Synthesis and characterization of αvβ₃-targeting peptidomimetic chelate conjugates for PET and SPECT imaging.
Bioorganic & medicinal chemistry letters 2012;22(17):5517-22.
2012: Young-Seung Kim; Martin W Brechbiel
An overview of targeted alpha therapy.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2012;33(3):573-90.
2012: Kido Nwe; Geoffrey L Ray; Young-Seung Kim; Diane E Milenic; Martin W Brechbiel
Preparation of cystamine core dendrimer and antibody-dendrimer conjugates for MRI angiography.
Molecular pharmaceutics 2012;9(3):374-81.
2012: Kwon Joong Yong; Diane E Milenic; Kwamena Baidoo; Martin W Brechbiel
(212)Pb-radioimmunotherapy induces G(2) cell-cycle arrest and delays DNA damage repair in tumor xenografts in a model for disseminated intraperitoneal disease.
Molecular cancer therapeutics 2012;11(3):639-48.
2011: Mamta Dadwal; Anzhi Dai; Chi Soo Kang; Hyun A Song; Xiang Sun; Kwamena Baidoo; Martin W Brechbiel; Hyun-Soon Chong
Synthesis and evaluation of a bifunctional chelate for development of Bi(III)-labeled radioimmunoconjugates.
Bioorganic & medicinal chemistry letters 2011;21(24):7513-5.
2011: Ambika Bumb; Peter L Choyke; Peter J Dobson; Jackson G Egen; Ronald N Germain; Celeste A S Regino; Marcelino Bernardo; Martin W Brechbiel
Trafficking of a dual-modality magnetic resonance and fluorescence imaging superparamagnetic iron oxide-based nanoprobe to lymph nodes.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2011;13(6):1163-72.
2011: Ambika Bumb; Susanta K Sarkar; Xufeng S Wu; Martin W Brechbiel; Keir C Neuman
Quantitative characterization of fluorophores in multi-component nanoprobes by single-molecule fluorescence.
Biomedical optics express 2011;2(10):2761-9.
2011: Tapan K Nayak; Martin W Brechbiel
86Y based PET radiopharmaceuticals: radiochemistry and biological applications.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2011;7(5):380-8.
2011: Kwon Yong; Martin W Brechbiel
Towards translation of 212Pb as a clinical therapeutic; getting the lead in!
Dalton transactions (Cambridge, England : 2003) 2011;40(23):6068-76.
2011: Hyun A Song; Anzhi Dai; Chi Soo Kang; Diane E Milenic; Kwamena Baidoo; Martin W Brechbiel; Yunwei Chen; Hyun-Soon Chong
Efficient bifunctional decadentate ligand 3p-C-DEPA for targeted α-radioimmunotherapy applications.
Bioconjugate chemistry 2011;22(6):1128-35.
2011: Kido Nwe; Diane E Milenic; L Henry Bryant; Celeste A S Regino; Martin W Brechbiel
Preparation, characterization and in vivo assessment of Gd-albumin and Gd-dendrimer conjugates as intravascular contrast-enhancing agents for MRI.
Journal of inorganic biochemistry 2011;105(5):722-7.
2011: Tapan K Nayak; Kayhan Garmestani; Kwamena Baidoo; Diane E Milenic; Martin W Brechbiel
PET imaging of tumor angiogenesis in mice with VEGF-A-targeted (86)Y-CHX-A″-DTPA-bevacizumab.
International journal of cancer. Journal international du cancer 2011;128(4):920-6.
2011: Tapan K Nayak; Kayhan Garmestani; Diane E Milenic; Kwamena Baidoo; Martin W Brechbiel
HER1-targeted 86Y-panitumumab possesses superior targeting characteristics than 86Y-cetuximab for PET imaging of human malignant mesothelioma tumors xenografts.
PloS one 2011;6(3):e18198.
2010: Aaron Joseph L Villaraza; Diane E Milenic; Martin W Brechbiel
Improved speciation characteristics of PEGylated indocyanine green-labeled Panitumumab: revisiting the solution and spectroscopic properties of a near-infrared emitting anti-HER1 antibody for optical imaging of cancer.
Bioconjugate chemistry 2010;21(12):2305-12.
2010: Laureen M Sena; Steven J Fishman; Kathy J Jenkins; Heng Xu; Martin W Brechbiel; Celeste A S Regino; Nobuyuki Kosaka; Marcelino Bernardo; Peter L Choyke; Hisataka Kobayashi
Magnetic resonance lymphangiography with a nano-sized gadolinium-labeled dendrimer in small and large animal models.
Nanomedicine (London, England) 2010;5(8):1183-91.
2010: Diane E Milenic; Karen J Wong; Kwamena Baidoo; Tapan K Nayak; Celeste A S Regino; Kayhan Garmestani; Martin W Brechbiel
Targeting HER2: a report on the in vitro and in vivo pre-clinical data supporting trastuzumab as a radioimmunoconjugate for clinical trials.
mAbs 2010;2(5):550-64.
2010: Ambika Bumb; Martin W Brechbiel; Peter Choyke
Macromolecular and dendrimer-based magnetic resonance contrast agents.
Acta radiologica (Stockholm, Sweden : 1987) 2010;51(7):751-67.
2010: K Nwe; Marcelino Bernardo; Celeste A S Regino; M Williams; Martin W Brechbiel
Comparison of MRI properties between derivatized DTPA and DOTA gadolinium-dendrimer conjugates.
Bioorganic & medicinal chemistry 2010;18(16):5925-31.
2010: Tapan K Nayak; Celeste A S Regino; Karen J Wong; Diane E Milenic; Kayhan Garmestani; Kwamena Baidoo; Lawrence P Szajek; Martin W Brechbiel
PET imaging of HER1-expressing xenografts in mice with 86Y-CHX-A''-DTPA-cetuximab.
European journal of nuclear medicine and molecular imaging 2010;37(7):1368-76.
2010: Kido Nwe; L Henry Bryant; Martin W Brechbiel
Poly(amidoamine) dendrimer based MRI contrast agents exhibiting enhanced relaxivities derived via metal preligation techniques.
Bioconjugate chemistry 2010;21(6):1014-7.
2010: Tapan K Nayak; Kayhan Garmestani; Kwamena Baidoo; Diane E Milenic; Martin W Brechbiel
Preparation, biological evaluation, and pharmacokinetics of the human anti-HER1 monoclonal antibody panitumumab labeled with 86Y for quantitative PET of carcinoma.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010;51(6):942-50.
2010: Aaron Joseph L Villaraza; Ambika Bumb; Martin W Brechbiel
Macromolecules, dendrimers, and nanomaterials in magnetic resonance imaging: the interplay between size, function, and pharmacokinetics.
Chemical reviews 2010;110(5):2921-59.
2010: Diane E Milenic; Erik D Brady; Kayhan Garmestani; Paul S Albert; Alia Abdulla; Martin W Brechbiel
Improved efficacy of alpha-particle-targeted radiation therapy: dual targeting of human epidermal growth factor receptor-2 and tumor-associated glycoprotein 72.
Cancer 2010;116(4 Suppl):1059-66.
2009: Rebecca A Herbertson; Niall C Tebbutt; Fook-Thean Lee; David J MacFarlane; Bridget Chappell; Noel Micallef; Sze-Ting Lee; Timothy Saunder; Wendie Hopkins; Fiona E Smyth; david wyld; John Bellen; Daryl S Sonnichsen; Martin W Brechbiel; Carmel Murone; Andrew M Scott
Phase I biodistribution and pharmacokinetic study of Lewis Y-targeting immunoconjugate CMD-193 in patients with advanced epithelial cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(21):6709-15.
2009: G L Ray; Kwamena Baidoo; Karen J Wong; M Williams; Kayhan Garmestani; Martin W Brechbiel; Diane E Milenic
Preclinical evaluation of a monoclonal antibody targeting the epidermal growth factor receptor as a radioimmunodiagnostic and radioimmunotherapeutic agent.
British journal of pharmacology 2009;157(8):1541-8.
2009: Heng Xu; Peter K Eck; Kwamena Baidoo; Peter L Choyke; Martin W Brechbiel
Toward preparation of antibody-based imaging probe libraries for dual-modality positron emission tomography and fluorescence imaging.
Bioorganic & medicinal chemistry 2009;17(14):5176-81.
2009: Kido Nwe; Heng Xu; Celeste A S Regino; Marcelino Bernardo; Lilia Ileva; Lisa Riffle; Karen J Wong; Martin W Brechbiel
A new approach in the preparation of dendrimer-based bifunctional diethylenetriaminepentaacetic acid MR contrast agent derivatives.
Bioconjugate chemistry 2009;20(7):1412-8.
2009: Meili Zhang; Zhengsheng Yao; Kayhan Garmestani; Sarah Yu; Carolyn K Goldman; Chang H Paik; Martin W Brechbiel; Jorge Carrasquillo; Thomas Waldmann
Preclinical evaluation of an anti-CD25 monoclonal antibody, 7G7/B6, armed with the beta-emitter, yttrium-90, as a radioimmunotherapeutic agent for treating lymphoma.
Cancer biotherapy & radiopharmaceuticals 2009;24(3):303-9.
2009: Kido Nwe; Martin W Brechbiel
Growing applications of "click chemistry" for bioconjugation in contemporary biomedical research.
Cancer biotherapy & radiopharmaceuticals 2009;24(3):289-302.
2009: Tapan K Nayak; Martin W Brechbiel
Radioimmunoimaging with longer-lived positron-emitting radionuclides: potentials and challenges.
Bioconjugate chemistry 2009;20(5):825-41.
2009: Lihui Wei; Xiuli Zhang; Fabio Gallazzi; Yubin Miao; Xiaofang Jin; Martin W Brechbiel; Heng Xu; Thomas Clifford; Michael J Welch; Jason S Lewis; Thomas P Quinn
Melanoma imaging using (111)In-, (86)Y- and (68)Ga-labeled CHX-A''-Re(Arg11)CCMSH.
Nuclear medicine and biology 2009;36(4):345-54.
2009: C Andrew Boswell; Celeste A S Regino; Kwamena Baidoo; Karen J Wong; Diane E Milenic; James A Kelley; Christopher C Lai; Martin W Brechbiel
A novel side-bridged hybrid phosphonate/acetate pendant cyclam: synthesis, characterization, and 64Cu small animal PET imaging.
Bioorganic & medicinal chemistry 2009;17(2):548-52.
2009: Marcus Kelly; Sze Ting Lee; F-T Lee; Fiona E Smyth; Ian D Davis; Martin W Brechbiel; Andrew M Scott
Therapeutic efficacy of 177Lu-CHX-A''-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy.
The Prostate 2009;69(1):92-104.
2008: Hyun-Soon Chong; Sooyoun Lim; Kwamena Baidoo; Diane E Milenic; Xiang Ma; Fang Jia; Hyun A Song; Martin W Brechbiel; Michael R Lewis
Synthesis and biological evaluation of a novel decadentate ligand DEPA.
Bioorganic & medicinal chemistry letters 2008;18(21):5792-5.
2008: Diane E Milenic; Karen J Wong; Kwamena Baidoo; Geoffrey L Ray; Kayhan Garmestani; Mark Williams; Martin W Brechbiel
Cetuximab: preclinical evaluation of a monoclonal antibody targeting EGFR for radioimmunodiagnostic and radioimmunotherapeutic applications.
Cancer biotherapy & radiopharmaceuticals 2008;23(5):619-31.
2008: Diane E Milenic; Kayhan Garmestani; Erik D Brady; Kwamena Baidoo; Paul S Albert; Karen J Wong; Joseph Flynn; Martin W Brechbiel
Multimodality therapy: potentiation of high linear energy transfer radiation with paclitaxel for the treatment of disseminated peritoneal disease.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(16):5108-15.
2008: Marcus Kelly; Fook-Thean Lee; Kiki Tahtis; Barbara E Power; Fiona E Smyth; Martin W Brechbiel; Peter J Hudson; Andrew M Scott
Tumor targeting by a multivalent single-chain Fv (scFv) anti-Lewis Y antibody construct.
Cancer biotherapy & radiopharmaceuticals 2008;23(4):411-23.
2008: Vladimir Tolmachev; Heng Xu; Helena Wållberg; Sara Ahlgren; Magnus Hjertman; Anna Sjöberg; Mattias Sandström; Lars Abrahmsén; Martin W Brechbiel; Anna Orlova
Evaluation of a maleimido derivative of CHX-A'' DTPA for site-specific labeling of affibody molecules.
Bioconjugate chemistry 2008;19(8):1579-87.
2008: C Andrew Boswell; Celeste A S Regino; Kwamena Baidoo; Karen J Wong; Ambika Bumb; Heng Xu; Diane E Milenic; James A Kelley; Christopher C Lai; Martin W Brechbiel
Synthesis of a cross-bridged cyclam derivative for peptide conjugation and 64Cu radiolabeling.
Bioconjugate chemistry 2008;19(7):1476-84.
2008: Hyun-Soon Chong; Hyun A Song; Xiang Ma; Diane E Milenic; Erik D Brady; Sooyoun Lim; Haisung Lee; Kwamena Baidoo; Dengfeng Cheng; Martin W Brechbiel
Novel bimodal bifunctional ligands for radioimmunotherapy and targeted MRI.
Bioconjugate chemistry 2008;19(7):1439-47.
2008: C Andrew Boswell; Peter K Eck; Celeste A S Regino; Marcelino Bernardo; Karen J Wong; Diane E Milenic; Peter L Choyke; Martin W Brechbiel
Synthesis, characterization, and biological evaluation of integrin alphavbeta3-targeted PAMAM dendrimers.
Molecular pharmaceutics 2008;5(4):527-39.
2008: Martin W Brechbiel
Bifunctional chelates for metal nuclides.
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology 2008;52(2):166-73.
2008: Heng Xu; Kwamena Baidoo; Karen J Wong; Martin W Brechbiel
A novel bifunctional maleimido CHX-A'' chelator for conjugation to thiol-containing biomolecules.
Bioorganic & medicinal chemistry letters 2008;18(8):2679-83.
2008: Matthew K Robinson; Calvin Shaller; Kayhan Garmestani; Paul S Plascjak; Kathryn M Hodge; Qing-An Yuan; James D Marks; Thomas Waldmann; Martin W Brechbiel; Gregory P Adams
Effective treatment of established human breast tumor xenografts in immunodeficient mice with a single dose of the alpha-emitting radioisotope astatine-211 conjugated to anti-HER2/neu diabodies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(3):875-82.
2008: Hyun-Soon Chong; Xiang Ma; Thien Le; Baidoo Kwamena; Diane E Milenic; Erik D Brady; Hyun A Song; Martin W Brechbiel
Rational design and generation of a bimodal bifunctional ligand for antibody-targeted radiation cancer therapy.
Journal of medicinal chemistry 2008;51(1):118-25.
2008: Celeste A S Regino; Stuart Walbridge; Marcelino Bernardo; Karen J Wong; Dennis Johnson; Russell Lonser; Edward H Oldfield; Peter L Choyke; Martin W Brechbiel
A dual CT-MR dendrimer contrast agent as a surrogate marker for convection-enhanced delivery of intracerebral macromolecular therapeutic agents.
Contrast media & molecular imaging 2008;3(1):2-8.
2008: D Scott Wilbur; Donald K Hamlin; Ming-Kuan Chyan; Martin W Brechbiel
Streptavidin in antibody pretargeting. 5. chemical modification of recombinant streptavidin for labeling with the alpha-particle-emitting radionuclides 213Bi and 211At.
Bioconjugate chemistry 2008;19(1):158-70.
2008: Matt L Childers; Joonhyung Cho; Celeste A S Regino; Martin W Brechbiel; Antonio G DiPasquale; Arnold L Rheingold; Suzy V Torti; Frank M Torti; Roy P Planalp
Influence of ligand structure on Fe(II) spin-state and redox rate in cytotoxic tripodal chelators.
Journal of inorganic biochemistry 2008;102(1):150-6.
2007: Martin W Brechbiel
Targeted alpha-therapy: past, present, future?
Dalton transactions (Cambridge, England : 2003) 2007;(43):4918-28.
2007: Hyun-Soon Chong; Santosh Mhaske; Mai Lin; Sankar Bhuniya; Hyun A Song; Martin W Brechbiel; Xiankai Sun
Novel synthetic ligands for targeted PET imaging and radiotherapy of copper.
Bioorganic & medicinal chemistry letters 2007;17(22):6107-10.
2007: C Andrew Boswell; Martin W Brechbiel
Development of radioimmunotherapeutic and diagnostic antibodies: an inside-out view.
Nuclear medicine and biology 2007;34(7):757-78.
2007: Heng Xu; Kwamena Baidoo; Andrew J Gunn; C Andrew Boswell; Diane E Milenic; Peter L Choyke; Martin W Brechbiel
Design, synthesis, and characterization of a dual modality positron emission tomography and fluorescence imaging agent for monoclonal antibody tumor-targeted imaging.
Journal of medicinal chemistry 2007;50(19):4759-65.
2007: Marcus Kelly; Fook-Thean Lee; Kiki Tahtis; Fiona E Smyth; Martin W Brechbiel; Andrew M Scott
Radioimmunotherapy with alpha-particle emitting 213Bi-C-functionalized trans-cyclohexyl-diethylenetriaminepentaacetic acid-humanized 3S193 is enhanced by combination with paclitaxel chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(18 Pt 2):5604s-5612s.
2007: Heng Xu; Celeste A S Regino; Yoshinori Koyama; Yukihiro Hama; Andrew J Gunn; Marcelino Bernardo; Hisataka Kobayashi; Peter L Choyke; Martin W Brechbiel
Preparation and preliminary evaluation of a biotin-targeted, lectin-targeted dendrimer-based probe for dual-modality magnetic resonance and fluorescence imaging.
Bioconjugate chemistry 2007;18(5):1474-82.
2007: Daniel A Vallera; Andy Sicheneder; Elizabeth Taras; Martin W Brechbiel; Jesse A Vallera; Angela Panoskaltsis-Mortari; Linda J Burns
Radiotherapy of CD45-expressing Daudi tumors in nude mice with yttrium-90-labeled, PEGylated anti-CD45 antibody.
Cancer biotherapy & radiopharmaceuticals 2007;22(4):488-500.
2007: Tristan Barrett; Martin W Brechbiel; Marcelino Bernardo; Peter L Choyke
MRI of tumor angiogenesis.
Journal of magnetic resonance imaging : JMRI 2007;26(2):235-49.
2007: Heng Xu; Celeste A S Regino; Marcelino Bernardo; Yoshinori Koyama; Hisataka Kobayashi; Peter L Choyke; Martin W Brechbiel
Toward improved syntheses of dendrimer-based magnetic resonance imaging contrast agents: new bifunctional diethylenetriaminepentaacetic acid ligands and nonaqueous conjugation chemistry.
Journal of medicinal chemistry 2007;50(14):3185-93.
2007: Andrew J Gunn; Martin W Brechbiel; Peter L Choyke
The emerging role of molecular imaging and targeted therapeutics in peritoneal carcinomatosis.
Expert opinion on drug delivery 2007;4(4):389-402.
2007: Emma Y Song; Syed M Abbas Rizvi; Chang F Qu; Chand Raja; Martin W Brechbiel; Alfred Morgenstern; Christos Apostolidis; Barry J Allen
Pharmacokinetics and toxicity of (213)Bi-labeled PAI2 in preclinical targeted alpha therapy for cancer.
Cancer biology & therapy 2007;6(6):898-904.
2007: Andrew M Scott; Niall Tebbutt; Fook-Thean Lee; Tina Cavicchiolo; Zhanqi Liu; Sanjeev Gill; Aurora M T Poon; Wendie Hopkins; Fiona E Smyth; Carmel Murone; Duncan MacGregor; Anthony T Papenfuss; Bridget Chappell; Tim Saunder; Martin W Brechbiel; Ian D Davis; Roger Murphy; Geoffrey Chong; Eric W Hoffman; Lloyd J Old
A phase I biodistribution and pharmacokinetic trial of humanized monoclonal antibody Hu3s193 in patients with advanced epithelial cancers that express the Lewis-Y antigen.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(11):3286-92.
2007: Meili Zhang; Zhengsheng Yao; Hiral Patel; Kayhan Garmestani; Zhuo Zhang; Vladimir S Talanov; Paul S Plascjak; Carolyn K Goldman; John Janik; Martin W Brechbiel; Thomas Waldmann
Effective therapy of murine models of human leukemia and lymphoma with radiolabeled anti-CD30 antibody, HeFi-1.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(20):8444-8.
2007: Yoshinori Koyama; Vladimir S Talanov; Marcelino Bernardo; Yukihiro Hama; Celeste A S Regino; Martin W Brechbiel; Peter L Choyke; Hisataka Kobayashi
A dendrimer-based nanosized contrast agent dual-labeled for magnetic resonance and optical fluorescence imaging to localize the sentinel lymph node in mice.
Journal of magnetic resonance imaging : JMRI 2007;25(4):866-71.
2007: Diane E Milenic; Kayhan Garmestani; Erik D Brady; Paul S Albert; Alia Abdulla; Joseph Flynn; Martin W Brechbiel
Potentiation of high-LET radiation by gemcitabine: targeting HER2 with trastuzumab to treat disseminated peritoneal disease.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(6):1926-35.
2007: Andrew M Scott; Fook-Thean Lee; Niall Tebbutt; Rebecca Herbertson; Sanjeev S Gill; Zhanqi Liu; Effie Skrinos; Carmel Murone; Tim Saunder; Bridget Chappell; Anthony T Papenfuss; Aurora M T Poon; Wendie Hopkins; Fiona E Smyth; Duncan MacGregor; Lawrence M Cher; Achim A Jungbluth; Gerd Ritter; Martin W Brechbiel; Roger Murphy; Antony W Burgess; Eric W Hoffman; Terrance G Johns; Lloyd J Old
A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4071-6.
2007: Yukihiro Hama; Marcelino Bernardo; Celeste A S Regino; Yoshinori Koyama; Martin W Brechbiel; Murali K Cherukuri; Peter L Choyke; Hisataka Kobayashi
MR lymphangiography using dendrimer-based contrast agents: a comparison at 1.5T and 3.0T.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2007;57(2):431-6.
2006: Tristan Barrett; Hisataka Kobayashi; Martin W Brechbiel; Peter L Choyke
Macromolecular MRI contrast agents for imaging tumor angiogenesis.
European journal of radiology 2006;60(3):353-66.
2006: Ekaterina Dadachova; Mahesh C Patel; Sima Toussi; Christos Apostolidis; Alfred Morgenstern; Martin W Brechbiel; Miroslaw K Gorny; Susan Zolla-Pazner; Arturo Casadevall; Harris Goldstein
Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins.
PLoS medicine 2006;3(11):e427.
2006: Meili Zhang; Zhengsheng Yao; Zhuo Zhang; Kayhan Garmestani; Vladimir S Talanov; Paul S Plascjak; Sarah Yu; Hyung-Sik Kim; Carolyn K Goldman; Chang H Paik; Martin W Brechbiel; Jorge Carrasquillo; Thomas Waldmann
The anti-CD25 monoclonal antibody 7G7/B6, armed with the alpha-emitter 211At, provides effective radioimmunotherapy for a murine model of leukemia.
Cancer research 2006;66(16):8227-32.
2006: Zhuo Zhang; Meili Zhang; Kayhan Garmestani; Vladimir S Talanov; Paul S Plascjak; Barbara Beck; Carolyn K Goldman; Martin W Brechbiel; Thomas Waldmann
Effective treatment of a murine model of adult T-cell leukemia using 211At-7G7/B6 and its combination with unmodified anti-Tac (daclizumab) directed toward CD25.
Blood 2006;108(3):1007-12.
2006: Meili Zhang; Zhengsheng Yao; Zhuo Zhang; Kayhan Garmestani; Carolyn K Goldman; Jeffrey V Ravetch; John Janik; Martin W Brechbiel; Thomas Waldmann
Effective therapy for a murine model of human anaplastic large-cell lymphoma with the anti-CD30 monoclonal antibody, HeFi-1, does not require activating Fc receptors.
Blood 2006;108(2):705-10.
2006: Thomas Clifford; C Andrew Boswell; Grainne B Biddlecombe; Jason S Lewis; Martin W Brechbiel
Validation of a novel CHX-A'' derivative suitable for peptide conjugation: small animal PET/CT imaging using yttrium-86-CHX-A''-octreotide.
Journal of medicinal chemistry 2006;49(14):4297-304.
2006: Vladimir S Talanov; Celeste A S Regino; Hisataka Kobayashi; Marcelino Bernardo; Peter L Choyke; Martin W Brechbiel
Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging.
Nano letters 2006;6(7):1459-63.
2006: Gregory J A Murad; Stuart Walbridge; Paul F Morrison; Kayhan Garmestani; Jeffrey W Degen; Martin W Brechbiel; Edward H Oldfield; Russell R Lonser
Real-time, image-guided, convection-enhanced delivery of interleukin 13 bound to pseudomonas exotoxin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(10):3145-51.
2006: Vladimir S Talanov; Kayhan Garmestani; Celeste A S Regino; Diane E Milenic; Paul S Plascjak; Thomas Waldmann; Martin W Brechbiel
Preparation and in vivo evaluation of a novel stabilized linker for 211At labeling of protein.
Nuclear medicine and biology 2006;33(4):469-80.
2006: Hyun-Soon Chong; Diane E Milenic; Kayhan Garmestani; Erik D Brady; Hans Arora; Candice Pfiester; Martin W Brechbiel
In vitro and in vivo evaluation of novel ligands for radioimmunotherapy.
Nuclear medicine and biology 2006;33(4):459-67.
2006: Hisataka Kobayashi; Satomi Kawamoto; Marcelino Bernardo; Martin W Brechbiel; Michael V Knopp; Peter L Choyke
Delivery of gadolinium-labeled nanoparticles to the sentinel lymph node: comparison of the sentinel node visualization and estimations of intra-nodal gadolinium concentration by the magnetic resonance imaging.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(3):343-51.
2006: Marcus Kelly; Fook-Thean Lee; Fiona E Smyth; Martin W Brechbiel; Andrew M Scott
Enhanced efficacy of 90Y-radiolabeled anti-Lewis Y humanized monoclonal antibody hu3S193 and paclitaxel combined-modality radioimmunotherapy in a breast cancer model.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(4):716-25.
2006: Hyun-Soon Chong; Kayhan Garmestani; L Henry Bryant; Diane E Milenic; Terrish Overstreet; Noah Birch; Thien Le; Erik D Brady; Martin W Brechbiel
Synthesis and evaluation of novel macrocyclic and acyclic ligands as contrast enhancement agents for magnetic resonance imaging.
Journal of medicinal chemistry 2006;49(6):2055-62.
2006: Jeffrey P Norenberg; Boudewijn J Krenning; Inge R H M Konings; Donna F Kusewitt; Tapan K Nayak; Tamara L Anderson; Marion de Jong; Kayhan Garmestani; Martin W Brechbiel; Larry K Kvols
213Bi-[DOTA0, Tyr3]octreotide peptide receptor radionuclide therapy of pancreatic tumors in a preclinical animal model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(3 Pt 1):897-903.
2006: Rosemary S L Wong; Martin W Brechbiel
National cancer institute perspectives.
International journal of radiation oncology, biology, physics 2006;66(2 Suppl):S96-9.
2006: James W Dear; Hisataka Kobayashi; Martin W Brechbiel; robert star
Imaging acute renal failure with polyamine dendrimer-based MRI contrast agents.
Nephron. Clinical practice 2006;103(2):c45-9.
2005: Celeste A S Regino; Suzy V Torti; Rong Ma; Glenn P A Yap; Kevin A Kreisel; Frank M Torti; Roy P Planalp; Martin W Brechbiel
N-picolyl derivatives of Kemp's triamine as potential antitumor agents: a preliminary investigation.
Journal of medicinal chemistry 2005;48(25):7993-9.
2005: Hisataka Kobayashi; Martin W Brechbiel
Nano-sized MRI contrast agents with dendrimer cores.
Advanced drug delivery reviews 2005;57(15):2271-86.
2005: C Andrew Boswell; Martin W Brechbiel
Auger electrons: lethal, low energy, and coming soon to a tumor cell nucleus near you.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(12):1946-7.
2005: Hisataka Kobayashi; Satomi Kawamoto; Martin W Brechbiel; Marcelino Bernardo; Noriko Sato; Thomas Waldmann; Yutaka Tagaya; Peter L Choyke
Detection of lymph node involvement in hematologic malignancies using micromagnetic resonance lymphangiography with a gadolinum-labeled dendrimer nanoparticle.
Neoplasia (New York, N.Y.) 2005;7(11):984-91.
2005: Daniel A Vallera; Martin W Brechbiel; Linda J Burns; Angela Panoskaltsis-Mortari; Kathryn E Dusenbery; Dennis R Clohisy; Ellen S Vitetta
Radioimmunotherapy of CD22-expressing Daudi tumors in nude mice with a 90Y-labeled anti-CD22 monoclonal antibody.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(21):7920-8.
2005: Suzy V Torti; Rong Ma; Vincent J Venditto; Frank M Torti; Roy P Planalp; Martin W Brechbiel
Preliminary evaluation of the cytotoxicity of a series of tris-2-aminoethylamine (Tren) based hexadentate heterocyclic donor agents.
Bioorganic & medicinal chemistry 2005;13(21):5961-7.
2005: Jolyn Turner; Constantinos Koumenis; Timothy E Kute; Roy P Planalp; Martin W Brechbiel; Dillon I Beardsley; Brooke Cody; Kevin D Brown; Frank M Torti; Suzy V Torti
Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation.
Blood 2005;106(9):3191-9.
2005: Diane E Milenic; Kayhan Garmestani; Erik D Brady; Paul S Albert; Dangshe Ma; Alia Abdulla; Martin W Brechbiel
Alpha-particle radioimmunotherapy of disseminated peritoneal disease using a (212)Pb-labeled radioimmunoconjugate targeting HER2.
Cancer biotherapy & radiopharmaceuticals 2005;20(5):557-68.
2005: Buck E Rogers; Peter L Roberson; Sui Shen; Muhammad B Khazaeli; Mark Carpenter; Shigeru Yokoyama; Martin W Brechbiel; Albert F LoBuglio; Donald J Buchsbaum
Intraperitoneal radioimmunotherapy with a humanized anti-TAG-72 (CC49) antibody with a deleted CH2 region.
Cancer biotherapy & radiopharmaceuticals 2005;20(5):502-13.
2005: Fook-Thean Lee; Angela J Mountain; Marcus Kelly; Cathrine Hall; Angela Rigopoulos; Terrance G Johns; Fiona E Smyth; Martin W Brechbiel; Edouard C Nice; Antony W Burgess; Andrew M Scott
Enhanced efficacy of radioimmunotherapy with 90Y-CHX-A''-DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(19 Pt 2):7080s-7086s.
2005: Chang F Qu; Yan J Songl; Syed M A Rizvi; Yong Li; Ross Smith; Alan C Perkins; Alfred Morgenstern; Martin W Brechbiel; Barry J Allen
In vivo and in vitro inhibition of pancreatic cancer growth by targeted alpha therapy using 213Bi-CHX.A"-C595.
Cancer biology & therapy 2005;4(8):848-53.
2005: Christopher Vearing; Fook-Thean Lee; Sabine H Wimmer-Kleikamp; Violeta Spirkoska; Catherine To; Con Stylianou; Mark Spanevello; Martin W Brechbiel; Andrew W Boyd; Andrew M Scott; Martin Lackmann
Concurrent binding of anti-EphA3 antibody and ephrin-A5 amplifies EphA3 signaling and downstream responses: potential as EphA3-specific tumor-targeting reagents.
Cancer research 2005;65(15):6745-54.
2005: Vincent J Venditto; Celeste A S Regino; Martin W Brechbiel
PAMAM dendrimer based macromolecules as improved contrast agents.
Molecular pharmaceutics 2005;2(4):302-11.
2005: Noriko Sato; Raffit Hassan; Axworthy Don; Karen J Wong; Sarah Yu; Louis J Theodore; Yukang Lin; Luke Park; Martin W Brechbiel; Ira Pastan; Chang H Paik; Jorge Carrasquillo
Pretargeted radioimmunotherapy of mesothelin-expressing cancer using a tetravalent single-chain Fv-streptavidin fusion protein.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(7):1201-9.
2005: James W Dear; Hisataka Kobayashi; Sang-Kyung Jo; Mikaela K Holly; Xuzhen Hu; Peter S T Yuen; Martin W Brechbiel; robert star
Dendrimer-enhanced MRI as a diagnostic and prognostic biomarker of sepsis-induced acute renal failure in aged mice.
Kidney international 2005;67(6):2159-67.
2005: Kayhan Garmestani; Diane E Milenic; Erik D Brady; Paul S Plascjak; Martin W Brechbiel
Purification of cyclotron-produced 203Pb for labeling Herceptin.
Nuclear medicine and biology 2005;32(3):301-5.
2005: C Panousis; V M Rayzman; Terrance G Johns; C Renner; Zhanqi Liu; Glenn A Cartwright; Fook-Thean Lee; D Wang; Hui K Gan; D Cao; A Kypridis; Fiona E Smyth; Martin W Brechbiel; Antony W Burgess; Lloyd J Old; Andrew M Scott
Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR.
British journal of cancer 2005;92(6):1069-77.
2004: Diane E Milenic; Kayhan Garmestani; Erik D Brady; Paul S Albert; Dangshe Ma; Alia Abdulla; Martin W Brechbiel
Targeting of HER2 antigen for the treatment of disseminated peritoneal disease.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(23):7834-41.
2004: Hisataka Kobayashi; Martin W Brechbiel
Dendrimer-based nanosized MRI contrast agents.
Current pharmaceutical biotechnology 2004;5(6):539-49.
2004: Hisataka Kobayashi; Koen Reijnders; Sean English; Alexander T Yordanov; Diane E Milenic; Anastasia L Sowers; Deborah Citrin; Murali K Cherukuri; Thomas Waldmann; James B Mitchell; Martin W Brechbiel
Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(22):7712-20.
2004: Vladimir S Talanov; Alexander T Yordanov; Kayhan Garmestani; Diane E Milenic; Hans C Arora; Paul S Plascjak; William Eckelman; Thomas Waldmann; Martin W Brechbiel
Preparation and in vivo evaluation of novel linkers for 211At labeling of proteins.
Nuclear medicine and biology 2004;31(8):1061-71.
2004: Hyun-Soon Chong; Suzy V Torti; Rong Ma; Frank M Torti; Martin W Brechbiel
Synthesis and potent antitumor activities of novel 1,3,5-cis,cis-triaminocyclohexane N-pyridyl derivatives.
Journal of medicinal chemistry 2004;47(21):5230-4.
2004: Kevin A Camphausen; Mary Sproull; Steve Tantama; Vincent J Venditto; Sandeep Sankineni; Tamalee Scott; Martin W Brechbiel
Evaluation of chelating agents as anti-angiogenic therapy through copper chelation.
Bioorganic & medicinal chemistry 2004;12(19):5133-40.
2004: Deedee K Smart; Karen L Ortiz; David Mattson; C Matthew Bradbury; Kheem S Bisht; Leah K Sieck; Martin W Brechbiel; David Gius
Thioredoxin reductase as a potential molecular target for anticancer agents that induce oxidative stress.
Cancer research 2004;64(18):6716-24.
2004: Gregory P Adams; Calvin Shaller; Ekaterina Dadachova; Heidi H Simmons; Eva M Horak; Abohawariat Tesfaye; Andres J P Klein-Szanto; James D Marks; Martin W Brechbiel; Louis M Weiner
A single treatment of yttrium-90-labeled CHX-A"-C6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice.
Cancer research 2004;64(17):6200-6.
2004: Paul E Wallner; C Norman Coleman; Martin W Brechbiel; Diane E Milenic; Prabhakar Tripuraneni
Are radiation oncologists serious about systemic radiation therapy and if not, should we be?
International journal of radiation oncology, biology, physics 2004;60(1):1-2.
2004: Hisataka Kobayashi; Sang-Kyung Jo; Satomi Kawamoto; Hideo Yasuda; Xuzhen Hu; Michael V Knopp; Martin W Brechbiel; Peter L Choyke; robert star
Polyamine dendrimer-based MRI contrast agents for functional kidney imaging to diagnose acute renal failure.
Journal of magnetic resonance imaging : JMRI 2004;20(3):512-8.
2004: Wolfgang A Bethge; D Scott Wilbur; Rainer Storb; Donald K Hamlin; Erlinda B Santos; Martin W Brechbiel; Brenda M Sandmaier
Radioimmunotherapy with bismuth-213 as conditioning for nonmyeloablative allogeneic hematopoietic cell transplantation in dogs: a dose deescalation study.
Transplantation 2004;78(3):352-9.
2004: Meili Zhang; Zhuo Zhang; Kayhan Garmestani; Carolyn K Goldman; Jeffrey V Ravetch; Martin W Brechbiel; Jorge Carrasquillo; Thomas Waldmann
Activating Fc receptors are required for antitumor efficacy of the antibodies directed toward CD25 in a murine model of adult t-cell leukemia.
Cancer research 2004;64(16):5825-9.
2004: Erik D Brady; Hyun-Soon Chong; Diane E Milenic; Martin W Brechbiel
Development of a spectroscopic assay for bifunctional ligand-protein conjugates based on copper.
Nuclear medicine and biology 2004;31(6):795-802.
2004: Erik D Brady; Diane E Milenic; Martin W Brechbiel
Antibody guided precision radiation therapy.
Discovery medicine 2004;4(22):213-9.
2004: Diane E Milenic; Erik D Brady; Martin W Brechbiel
Antibody-targeted radiation cancer therapy.
Nature reviews. Drug discovery 2004;3(6):488-99.
2004: Neng Ye; Gyungse Park; Ann M Przyborowska; Paula E Sloan; Thomas Clifford; Cay Brian Bauer; Grant A Broker; Robin D Rogers; Rong Ma; Suzy V Torti; Martin W Brechbiel; Roy P Planalp
Nickel(II), copper(II) and zinc(II) binding properties and cytotoxicity of tripodal, hexadentate tris(ethylenediamine)--analogue chelators.
Dalton transactions (Cambridge, England : 2003) 2004;(9):1304-11.
2004: Hisataka Kobayashi; Satomi Kawamoto; Yoshio Sakai; Peter L Choyke; robert star; Martin W Brechbiel; Noriko Sato; Yutaka Tagaya; John C Morris; Thomas Waldmann
Lymphatic drainage imaging of breast cancer in mice by micro-magnetic resonance lymphangiography using a nano-size paramagnetic contrast agent.
Journal of the National Cancer Institute 2004;96(9):703-8.
2004: Zhengsheng Yao; Meili Zhang; Kayhan Garmestani; Axworthy Don; Robert W Mallett; Alan R Fritzberg; Louis J Theodore; Paul S Plascjak; William Eckelman; Thomas Waldmann; Ira Pastan; Chang H Paik; Martin W Brechbiel; Jorge Carrasquillo
Pretargeted alpha emitting radioimmunotherapy using (213)Bi 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid-biotin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):3137-46.
2004: Rong Zhao; Roy P Planalp; Rong Ma; Bryan T Greene; Bradley T Jones; Martin W Brechbiel; Frank M Torti; Suzy V Torti
Role of zinc and iron chelation in apoptosis mediated by tachpyridine, an anti-cancer iron chelator.
Biochemical pharmacology 2004;67(9):1677-88.
2004: Zhengsheng Yao; Weili Dai; James Perry; Martin W Brechbiel; Cynthia Sung
Effect of albumin fusion on the biodistribution of interleukin-2.
Cancer immunology, immunotherapy : CII 2004;53(5):404-10.
2004: Diane E Milenic; Kayhan Garmestani; Ekaterina Dadachova; Lara L Chappell; Paul Albert; Donald Hill; Jeffrey Schlom; Martin W Brechbiel
Radioimmunotherapy of human colon carcinoma xenografts using a 213Bi-labeled domain-deleted humanized monoclonal antibody.
Cancer biotherapy & radiopharmaceuticals 2004;19(2):135-47.
2004: Hisataka Kobayashi; Satomi Kawamoto; Martin W Brechbiel; Sang-Kyung Jo; Xuzhen Hu; Tianxin Yang; Bhalchandra A Diwan; Thomas Waldmann; Jurgen Schnermann; Peter L Choyke; robert star
Micro-MRI methods to detect renal cysts in mice.
Kidney international 2004;65(4):1511-6.
2004: Jon N Wesley; Edwin C McGee; Kayhan Garmestani; Martin W Brechbiel; Alexander T Yordanov; Chuanchu Wu; Otto A Gansow; William Eckelman; John Bacher; Michael Flynn; Carolyn K Goldman; Melvin MacLin; Uwe P Schwartz; Terri Jackson-White; Celeste M Phillip; Jean Decker; Thomas Waldmann
Systemic radioimmunotherapy using a monoclonal antibody, anti-Tac directed toward the alpha subunit of the IL-2 receptor armed with the alpha-emitting radionuclides (212)Bi or (211)At.
Nuclear medicine and biology 2004;31(3):357-64.
2004: Diane E Milenic; Martin W Brechbiel
Targeting of radio-isotopes for cancer therapy.
Cancer biology & therapy 2004;3(4):361-70.
2004: Marcelo Mamede; Tsuneo Saga; Takayoshi Ishimori; Tatsuya Higashi; Noriko Sato; Hisataka Kobayashi; Martin W Brechbiel; Junji Konishi
Hepatocyte targeting of 111In-labeled oligo-DNA with avidin or avidin-dendrimer complex.
Journal of controlled release : official journal of the Controlled Release Society 2004;95(1):133-41.
2004: Raya Mandler; Hisataka Kobayashi; Ella R Hinson; Martin W Brechbiel; Thomas Waldmann
Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity.
Cancer research 2004;64(4):1460-7.
2004: Daniel A Vallera; Michael Elson; Martin W Brechbiel; Kathryn E Dusenbery; Linda J Burns; Waclaw B Jaszcz; Norma K C Ramsay; Angela Panoskaltsis-Mortar; David W Kuroki; John E Wagner; Ellen S Vitetta; John H Kersey
Radiotherapy of CD19 expressing Daudi tumors in nude mice with Yttrium-90-labeled anti-CD19 antibody.
Cancer biotherapy & radiopharmaceuticals 2004;19(1):11-23.
2003: Kheem S Bisht; C Matthew Bradbury; David Mattson; Aradhana Kaushal; Anastasia L Sowers; Stephanie Markovina; Karen L Ortiz; Leah K Sieck; Jennifer S. Isaacs; Martin W Brechbiel; James B Mitchell; Leonard M Neckers; David Gius
Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.
Cancer research 2003;63(24):8984-95.
2003: Hisataka Kobayashi; Satomi Kawamoto; Peter L Choyke; Noriko Sato; Michael V Knopp; robert star; Thomas Waldmann; Yutaka Tagaya; Martin W Brechbiel
Comparison of dendrimer-based macromolecular contrast agents for dynamic micro-magnetic resonance lymphangiography.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2003;50(4):758-66.
2003: Steven J Wang; Martin W Brechbiel; Erik C Wiener
Characteristics of a new MRI contrast agent prepared from polypropyleneimine dendrimers, generation 2.
Investigative radiology 2003;38(10):662-8.
2003: Rosana B Michel; Adriane V Rosario; Martin W Brechbiel; Thomas J Jackson; David M Goldenberg; M Jules Mattes
Experimental therapy of disseminated B-Cell lymphoma xenografts with 213Bi-labeled anti-CD74.
Nuclear medicine and biology 2003;30(7):715-23.
2003: Kevin A Camphausen; Mary Sproull; Steve Tantama; Sandeep Sankineni; Tamalee Scott; Cynthia Ménard; C Norman Coleman; Martin W Brechbiel
Evaluation of copper chelation agents as anti-angiogenic therapy.
Bioorganic & medicinal chemistry 2003;11(19):4287-93.
2003: Marcelo Mamede; Tsuneo Saga; Hisataka Kobayashi; Takayoshi Ishimori; Tatsuya Higashi; Noriko Sato; Martin W Brechbiel; Junji Konishi
Radiolabeling of avidin with very high specific activity for internal radiation therapy of intraperitoneally disseminated tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3756-62.
2003: Hisataka Kobayashi; Satomi Kawamoto; robert star; Thomas Waldmann; Martin W Brechbiel; Peter L Choyke
Activated clearance of a biotinylated macromolecular MRI contrast agent from the blood pool using an avidin chase.
Bioconjugate chemistry 2003;14(5):1044-7.
2003: Lara L Chappell; Dangshe Ma; Diane E Milenic; Kayhan Garmestani; Vincent J Venditto; Markus Beitzel; Martin W Brechbiel
Synthesis and evaluation of novel bifunctional chelating agents based on 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid for radiolabeling proteins.
Nuclear medicine and biology 2003;30(6):581-95.
2003: Paul Mitchell; Fook-Thean Lee; Cathrine Hall; Angela Rigopoulos; Fiona E Smyth; Anne-Marie Hekman; Gijs M van Schijndel; Ray Powles; Martin W Brechbiel; Andrew M Scott
Targeting primary human Ph(+) B-cell precursor leukemia-engrafted SCID mice using radiolabeled anti-CD19 monoclonal antibodies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(7):1105-12.
2003: Wolfgang A Bethge; D Scott Wilbur; Rainer Storb; Donald K Hamlin; Erlinda B Santos; Martin W Brechbiel; Darrell R Fisher; Brenda M Sandmaier
Selective T-cell ablation with bismuth-213-labeled anti-TCRalphabeta as nonmyeloablative conditioning for allogeneic canine marrow transplantation.
Blood 2003;101(12):5068-75.
2003: Michael J Blend; Jerry J Stastny; Steven M Swanson; Martin W Brechbiel
Labeling anti-HER2/neu monoclonal antibodies with 111In and 90Y using a bifunctional DTPA chelating agent.
Cancer biotherapy & radiopharmaceuticals 2003;18(3):355-63.
2003: Mary Sproull; Martin W Brechbiel; Kevin A Camphausen
Antiangiogenic therapy through copper chelation.
Expert opinion on therapeutic targets 2003;7(3):405-9.
2003: Daniel A Vallera; M Elson; Martin W Brechbiel; Kathryn E Dusenbery; Linda J Burns; KM Skubitz; Waclaw B Jaszcz; Norma K C Ramsay; Angela Panoskaltsis-Mortari; David W Kuroki; J E Wagner; John H Kersey
Preclinical studies targeting normal and leukemic hematopoietic cells with Yttrium-90-labeled anti-CD45 antibody in vitro and in vivo in nude mice.
Cancer biotherapy & radiopharmaceuticals 2003;18(2):133-45.
2003: Rosana B Michel; Martin W Brechbiel; M Jules Mattes
A comparison of 4 radionuclides conjugated to antibodies for single-cell kill.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(4):632-40.
2003: Tung T Nguyen; Yashdip S Pannu; Cynthia Sung; Robert L Dedrick; Stuart Walbridge; Martin W Brechbiel; Kayhan Garmestani; Markus Beitzel; Alexander T Yordanov; Edward H Oldfield
Convective distribution of macromolecules in the primate brain demonstrated using computerized tomography and magnetic resonance imaging.
Journal of neurosurgery 2003;98(3):584-90.
2003: Hisataka Kobayashi; Satomi Kawamoto; Sang-Kyung Jo; Henry L Bryant; Martin W Brechbiel; robert star
Macromolecular MRI contrast agents with small dendrimers: pharmacokinetic differences between sizes and cores.
Bioconjugate chemistry 2003;14(2):388-94.
2003: Meili Zhang; Zhuo Zhang; Kayhan Garmestani; Jody Schultz; Axworthy Don; Carolyn K Goldman; Martin W Brechbiel; Jorge Carrasquillo; Thomas Waldmann
Pretarget radiotherapy with an anti-CD25 antibody-streptavidin fusion protein was effective in therapy of leukemia/lymphoma xenografts.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1891-5.
2003: Hisataka Kobayashi; Satomi Kawamoto; robert star; Thomas Waldmann; Yutaka Tagaya; Martin W Brechbiel
Micro-magnetic resonance lymphangiography in mice using a novel dendrimer-based magnetic resonance imaging contrast agent.
Cancer research 2003;63(2):271-6.
2003: Hisataka Kobayashi; Martin W Brechbiel
Dendrimer-based macromolecular MRI contrast agents: characteristics and application.
Molecular imaging 2003;2(1):1-10.
2002: Hyun-Soon Chong; Frank M Torti; Suzy V Torti; Martin W Brechbiel
Synthesis of 1,3,5-cis,cis-triaminocyclohexane N-pyridyl derivatives as potential antitumor agents.
The Journal of organic chemistry 2002;67(23):8072-8.
2002: Zhengsheng Yao; Meili Zhang; Axworthy Don; Karen J Wong; Kayhan Garmestani; Luke Park; Chang W Park; Robert W Mallett; Louis J Theodore; Eric K Yau; Thomas Waldmann; Martin W Brechbiel; Chang H Paik; Ira Pastan; Jorge Carrasquillo
Radioimmunotherapy of A431 xenografted mice with pretargeted B3 antibody-streptavidin and (90)Y-labeled 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA)-biotin.
Cancer research 2002;62(20):5755-60.
2002: Russell R Lonser; Stuart Walbridge; Kayhan Garmestani; John A Butman; Hugh A Walters; Alexander O Vortmeyer; Paul F Morrison; Martin W Brechbiel; Edward H Oldfield
Successful and safe perfusion of the primate brainstem: in vivo magnetic resonance imaging of macromolecular distribution during infusion.
Journal of neurosurgery 2002;97(4):905-13.
2002: D Scott Wilbur; Ming-Kuan Chyan; Donald K Hamlin; Brian B Kegley; Rune Nilsson; Bengt E B Sandberg; Martin W Brechbiel
Trifunctional conjugation reagents. Reagents that contain a biotin and a radiometal chelation moiety for application to extracorporeal affinity adsorption of radiolabeled antibodies.
Bioconjugate chemistry 2002;13(5):1079-92.
2002: Joseph G Jurcic; Steven M Larson; George Sgouros; Michael R McDevitt; Ronald D Finn; Chaitanya R Divgi; Ase M Ballangrud; Klaus A Hamacher; Dangshe Ma; John L Humm; Martin W Brechbiel; Roger Molinet; David A Scheinberg
Targeted alpha particle immunotherapy for myeloid leukemia.
Blood 2002;100(4):1233-9.
2002: Roy P Planalp; A M Przyborowska; Gyungse Park; N Ye; F H Lu; Robin D Rogers; G A Broker; Suzy V Torti; Martin W Brechbiel
Novel cytotoxic chelators that bind iron(II) selectively over zinc(II) under aqueous aerobic conditions.
Biochemical Society transactions 2002;30(4):758-62.
2002: Hisataka Kobayashi; Tsuneo Saga; Satomi Kawamoto; Noriko Sato; Akira Hiraga; Takayoshi Ishimori; Junji Konishi; Kaori Togashi; Martin W Brechbiel
Dynamic micro-MRI of liver micrometastasis with a novel liver macromolecular MR contrast agent DAB-Am64-(1B4M-Gd)64.
Academic radiology 2002;9 Suppl 2():S452-4.
2002: Erik C Wiener; Sheela D Konda; Steven Wang; Martin W Brechbiel
Imaging folate binding protein expression with MRI.
Academic radiology 2002;9 Suppl 2():S316-9.
2002: Hyun-Soon Chong; Kayhan Garmestani; Dangshe Ma; Diane E Milenic; Terrish Overstreet; Martin W Brechbiel
Synthesis and biological evaluation of novel macrocyclic ligands with pendent donor groups as potential yttrium chelators for radioimmunotherapy with improved complex formation kinetics.
Journal of medicinal chemistry 2002;45(16):3458-64.
2002: Bryan T Greene; Jacqueline Thorburn; Mark C Willingham; Andrew Thorburn; Roy P Planalp; Martin W Brechbiel; Jamie E Jennings-Gee; John C Wilkinson; Frank M Torti; Suzy V Torti
Activation of caspase pathways during iron chelator-mediated apoptosis.
The Journal of biological chemistry 2002;277(28):25568-75.
2002: Amram Samuni; Murali K Cherukuri; William DeGraff; Angelo Russo; Roy P Planalp; Martin W Brechbiel; James B Mitchell
Mechanisms underlying the cytotoxic effects of Tachpyr--a novel metal chelator.
Biochimica et biophysica acta 2002;1571(3):211-8.
2002: Raya Mandler; Hisataka Kobayashi; Marie Y Davis; Thomas Waldmann; Martin W Brechbiel
Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates.
Bioconjugate chemistry 2002;13(4):786-91.
2002: Kayhan Garmestani; Diane E Milenic; Paul S Plascjak; Martin W Brechbiel
A new and convenient method for purification of 86Y using a Sr(II) selective resin and comparison of biodistribution of 86Y and 111In labeled Herceptin.
Nuclear medicine and biology 2002;29(5):599-606.
2002: Brenda M Sandmaier; Wolfgang A Bethge; D Scott Wilbur; Donald K Hamlin; Erlinda B Santos; Martin W Brechbiel; Darrell R Fisher; Rainer Storb
Bismuth 213-labeled anti-CD45 radioimmunoconjugate to condition dogs for nonmyeloablative allogeneic marrow grafts.
Blood 2002;100(1):318-26.
2002: Meili Zhang; Zhengsheng Yao; Kayhan Garmestani; Axworthy Don; Zhuo Zhang; Robert W Mallett; Louis J Theodore; Carolyn K Goldman; Martin W Brechbiel; Jorge Carrasquillo; Thomas Waldmann
Pretargeting radioimmunotherapy of a murine model of adult T-cell leukemia with the alpha-emitting radionuclide, bismuth 213.
Blood 2002;100(1):208-16.
2002: Hisataka Kobayashi; Satomi Kawamoto; Sang-Kyung Jo; Noriko Sato; Tsuneo Saga; Akira Hiraga; Junji Konishi; Susan Hu; Kaori Togashi; Martin W Brechbiel; robert star
Renal tubular damage detected by dynamic micro-MRI with a dendrimer-based magnetic resonance contrast agent.
Kidney international 2002;61(6):1980-5.
2002: Stephen J Kennel; Saed Mirzadeh; William Eckelman; Thomas Waldmann; Kayhan Garmestani; Alexander T Yordanov; Michael G Stabin; Martin W Brechbiel
Vascular-targeted radioimmunotherapy with the alpha-particle emitter 211At.
Radiation research 2002;157(6):633-41.
2002: Alexander T Yordanov; Ken-ichi Yamada; Murali K Cherukuri; Angelo Russo; John Yoo; Sean English; James B Mitchell; Martin W Brechbiel
Acyl-protected hydroxylamines as spin label generators for EPR brain imaging.
Journal of medicinal chemistry 2002;45(11):2283-8.
2002: Diane E Milenic; Kayhan Garmestani; Lara L Chappell; Ekaterina Dadachova; Alexander T Yordanov; Dangshe Ma; Jeffrey Schlom; Martin W Brechbiel
In vivo comparison of macrocyclic and acyclic ligands for radiolabeling of monoclonal antibodies with 177Lu for radioimmunotherapeutic applications.
Nuclear medicine and biology 2002;29(4):431-42.
2002: Stephen J Kennel; Martin W Brechbiel; Diane E Milenic; Jeffrey Schlom; Saed Mirzadeh
Actinium-225 conjugates of MAb CC49 and humanized delta CH2CC49.
Cancer biotherapy & radiopharmaceuticals 2002;17(2):219-31.
2002: Sheela D Konda; Steven Wang; Martin W Brechbiel; Erik C Wiener
Biodistribution of a 153 Gd-folate dendrimer, generation = 4, in mice with folate-receptor positive and negative ovarian tumor xenografts.
Investigative radiology 2002;37(4):199-204.
2002: Michael Aref; Martin W Brechbiel; Erik C Wiener
Identifying tumor vascular permeability heterogeneity with magnetic resonance imaging contrast agents.
Investigative radiology 2002;37(4):178-92.
2002: William Eckelman; Joseph A Frank; Martin W Brechbiel
Theory and practice of imaging saturable binding sites.
Investigative radiology 2002;37(3):101-6.
2002: Hisataka Kobayashi; Kazuo Shirakawa; Satomi Kawamoto; Tsuneo Saga; Noriko Sato; Akira Hiraga; Ichiro Watanabe; Yuji Heike; Kaori Togashi; Junji Konishi; Martin W Brechbiel; Hiro Wakasugi
Rapid accumulation and internalization of radiolabeled herceptin in an inflammatory breast cancer xenograft with vasculogenic mimicry predicted by the contrast-enhanced dynamic MRI with the macromolecular contrast agent G6-(1B4M-Gd)(256).
Cancer research 2002;62(3):860-6.
2002: Kazuo Shirakawa; Hisataka Kobayashi; Yuji Heike; Satomi Kawamoto; Martin W Brechbiel; Fujio Kasumi; Toshihiko Iwanaga; Fumio Konishi; Masaaki Terada; Hiro Wakasugi
Hemodynamics in vasculogenic mimicry and angiogenesis of inflammatory breast cancer xenograft.
Cancer research 2002;62(2):560-6.
2002: Dangshe Ma; Michael R McDevitt; EC Barendswaard; L Lai; Michael J Curcio; Virginia A Pellegrini; Martin W Brechbiel; David A Scheinberg
Radioimmunotherapy for model B cell malignancies using 90Y-labeled anti-CD19 and anti-CD20 monoclonal antibodies.
Leukemia 2002;16(1):60-6.
2002: Dangshe Ma; Francis Lu; Terrish Overstreet; Diane E Milenic; Martin W Brechbiel
Novel chelating agents for potential clinical applications of copper.
Nuclear medicine and biology 2002;29(1):91-105.
2001: Hisataka Kobayashi; Satomi Kawamoto; Tsuneo Saga; Noriko Sato; Akira Hiraga; Junji Konishi; Kaori Togashi; Martin W Brechbiel
Micro-MR angiography of normal and intratumoral vessels in mice using dedicated intravascular MR contrast agents with high generation of polyamidoamine dendrimer core: reference to pharmacokinetic properties of dendrimer-based MR contrast agents.
Journal of magnetic resonance imaging : JMRI 2001;14(6):705-13.
2001: Noriko Sato; Hisataka Kobayashi; Akira Hiraga; Tsuneo Saga; Kaori Togashi; Junji Konishi; Martin W Brechbiel
Pharmacokinetics and enhancement patterns of macromolecular MR contrast agents with various sizes of polyamidoamine dendrimer cores.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(6):1169-73.
2001: Hyun-Soon Chong; Kayhan Garmestani; L H Bryant; Martin W Brechbiel
Synthesis of DTPA analogues derived from piperidine and azepane: potential contrast enhancement agents for magnetic resonance imaging.
The Journal of organic chemistry 2001;66(23):7745-50.
2001: Noriko Sato; Hisataka Kobayashi; Tsuneo Saga; Yuji Nakamoto; Takayoshi Ishimori; Kaori Togashi; Yasuhisa Fujibayashi; Junji Konishi; Martin W Brechbiel
Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(11):3606-12.
2001: Hisataka Kobayashi; Satomi Kawamoto; Tsuneo Saga; Noriko Sato; Akira Hiraga; Takayoshi Ishimori; Y Akita; Marcelo Mamede; Junji Konishi; Kaori Togashi; Martin W Brechbiel
Novel liver macromolecular MR contrast agent with a polypropylenimine diaminobutyl dendrimer core: comparison to the vascular MR contrast agent with the polyamidoamine dendrimer core.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(4):795-802.
2001: Hisataka Kobayashi; Satomi Kawamoto; Tsuneo Saga; Noriko Sato; Akira Hiraga; Takayoshi Ishimori; Junji Konishi; Kaori Togashi; Martin W Brechbiel
Positive effects of polyethylene glycol conjugation to generation-4 polyamidoamine dendrimers as macromolecular MR contrast agents.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(4):781-8.
2001: Andrew M Scott; Fook-Thean Lee; Wendie Hopkins; Jonathan Cebon; J M Wheatley; Zhanqi Liu; Fiona E Smyth; Carmel Murone; Sue Sturrock; Duncan MacGregor; Nobuo Hanai; K Inoue; M Yamasaki; Martin W Brechbiel; Ian D Davis; Roger Murphy; Anthony Hannah; M Lim-Joon; T Chan; Geoffrey Chong; Gerd Ritter; Eric W Hoffman; Antony W Burgess; Lloyd J Old
Specific targeting, biodistribution, and lack of immunogenicity of chimeric anti-GD3 monoclonal antibody KM871 in patients with metastatic melanoma: results of a phase I trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(19):3976-87.
2001: Alexander T Yordanov; Kayhan Garmestani; Meili Zhang; Zhuo Zhang; Zhengsheng Yao; K E Phillips; B Herring; EM Horak; Markus Beitzel; U P Schwarz; Otto A Gansow; Paul S Plascjak; William Eckelman; Thomas Waldmann; Martin W Brechbiel
Preparation and in vivo evaluation of linkers for 211At labeling of humanized anti-Tac.
Nuclear medicine and biology 2001;28(7):845-56.
2001: R D Abeysinghe; Bryan T Greene; R Haynes; Mark C Willingham; Jolyn Turner; Roy P Planalp; Martin W Brechbiel; Frank M Torti; Suzy V Torti
p53-independent apoptosis mediated by tachpyridine, an anti-cancer iron chelator.
Carcinogenesis 2001;22(10):1607-14.
2001: Hisataka Kobayashi; Noriko Sato; Satomi Kawamoto; Tsuneo Saga; Akira Hiraga; Takayoshi Ishimori; Junji Konishi; Kaori Togashi; Martin W Brechbiel
3D MR angiography of intratumoral vasculature using a novel macromolecular MR contrast agent.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(3):579-85.
2001: Hisataka Kobayashi; Noriko Sato; Satomi Kawamoto; Tsuneo Saga; Akira Hiraga; Takayoshi Ishimori; Junji Konishi; Kaori Togashi; Martin W Brechbiel
Novel intravascular macromolecular MRI contrast agent with generation-4 polyamidoamine dendrimer core: accelerated renal excretion with coinjection of lysine.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;46(3):457-64.
2001: K A Deal; Gyungse Park; J Shao; N Dennis Chasteen; Martin W Brechbiel; Roy P Planalp
Copper(II) complexes of novel N-alkylated derivatives of cis,cis-1,3,5-triaminocyclohexane. 2. Metal-promoted phosphate diester hydrolysis.
Inorganic chemistry 2001;40(17):4176-82.
2001: Gyungse Park; J Shao; F H Lu; Robin D Rogers; N Dennis Chasteen; Martin W Brechbiel; Roy P Planalp
Copper(II) complexes of novel N-alkylated derivatives of cis,cis-1,3,5-triaminocyclohexane. 1. Preparation and structure.
Inorganic chemistry 2001;40(17):4167-75.
2001: Ekaterina Dadachova; C Park; N Eberly; Dangshe Ma; Chang H Paik; Martin W Brechbiel
In vitro and in vivo characterization of 67Ga(3+) complexes with cis,cis-1,3,5-triamino-cyclohexane-N,N',N"-triacetic acid derivatives.
Nuclear medicine and biology 2001;28(6):695-701.
2001: A Lövqvist; John L Humm; Arif Sheikh; Ronald D Finn; Jacek Koziorowski; Shutian Ruan; Keith S Pentlow; Achim Jungbluth; Sydney Welt; F T Lee; Martin W Brechbiel; Steven M Larson
PET imaging of (86)Y-labeled anti-Lewis Y monoclonal antibodies in a nude mouse model: comparison between (86)Y and (111)In radiolabels.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2001;42(8):1281-7.
2001: S Hassfjell; Martin W Brechbiel
The development of the alpha-particle emitting radionuclides 212Bi and 213Bi, and their decay chain related radionuclides, for therapeutic applications.
Chemical reviews 2001;101(7):2019-36.
2001: Hisataka Kobayashi; Satomi Kawamoto; Tsuneo Saga; Noriko Sato; Takayoshi Ishimori; Junji Konishi; Koji Ono; Kaori Togashi; Martin W Brechbiel
Avidin-dendrimer-(1B4M-Gd)(254): a tumor-targeting therapeutic agent for gadolinium neutron capture therapy of intraperitoneal disseminated tumor which can be monitored by MRI.
Bioconjugate chemistry 2001;12(4):587-93.
2001: Martin W Brechbiel
Chelated metal ions for therapeutic and diagnostic applications.
Experimental biology and medicine (Maywood, N.J.) 2001;226(7):627-8.
2001: Hisataka Kobayashi; Tsuneo Saga; Satomi Kawamoto; Noriko Sato; Akira Hiraga; Takayoshi Ishimori; Junji Konishi; Kaori Togashi; Martin W Brechbiel
Dynamic micro-magnetic resonance imaging of liver micrometastasis in mice with a novel liver macromolecular magnetic resonance contrast agent DAB-Am64-(1B4M-Gd)(64).
Cancer research 2001;61(13):4966-70.
2001: Fook-Thean Lee; Angela Rigopoulos; Cathrine Hall; K Clarke; Stephen H Cody; Fiona E Smyth; Zhanqi Liu; Martin W Brechbiel; Nobuo Hanai; Edouard C Nice; Bruno Catimel; Antony W Burgess; Sydney Welt; Gerd Ritter; Lloyd J Old; Andrew M Scott
Specific localization, gamma camera imaging, and intracellular trafficking of radiolabelled chimeric anti-G(D3) ganglioside monoclonal antibody KM871 in SK-MEL-28 melanoma xenografts.
Cancer research 2001;61(11):4474-82.
2001: Kayhan Garmestani; Zhengsheng Yao; Meili Zhang; K Wong; Chang W Park; Ira Pastan; Jorge Carrasquillo; Martin W Brechbiel
Synthesis and evaluation of a macrocyclic bifunctional chelating agent for use with bismuth radionuclides.
Nuclear medicine and biology 2001;28(4):409-18.
2001: Sheela D Konda; Michael Aref; Steven Wang; Martin W Brechbiel; Erik C Wiener
Specific targeting of folate-dendrimer MRI contrast agents to the high affinity folate receptor expressed in ovarian tumor xenografts.
Magma (New York, N.Y.) 2001;12(2-3):104-13.
2001: C Renner; I Stehle; Fook-Thean Lee; Cathrine Hall; Bruno Catimel; Edouard C Nice; Angela J Mountain; Angela Rigopoulos; Martin W Brechbiel; Michael Pfreundschuh; Andrew M Scott
Targeting properties of an anti-CD16/anti-CD30 bispecific antibody in an in vivo system.
Cancer immunology, immunotherapy : CII 2001;50(2):102-8.
2001: Diane E Milenic; M Roselli; Saed Mirzadeh; CG Pippin; Otto A Gansow; David Colcher; Martin W Brechbiel; Jeffrey Schlom
In vivo evaluation of bismuth-labeled monoclonal antibody comparing DTPA-derived bifunctional chelates.
Cancer biotherapy & radiopharmaceuticals 2001;16(2):133-46.
2001: Kiki Tahtis; Fook-Thean Lee; Fiona E Smyth; Barbara E Power; C Renner; Martin W Brechbiel; Lloyd J Old; Peter J Hudson; Andrew M Scott
Biodistribution properties of (111)indium-labeled C-functionalized trans-cyclohexyl diethylenetriaminepentaacetic acid humanized 3S193 diabody and F(ab')(2) constructs in a breast carcinoma xenograft model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(4):1061-72.
2001: Hisataka Kobayashi; Noriko Sato; Akira Hiraga; Tsuneo Saga; Yuji Nakamoto; H Ueda; Junji Konishi; Kaori Togashi; Martin W Brechbiel
3D-micro-MR angiography of mice using macromolecular MR contrast agents with polyamidoamine dendrimer core with reference to their pharmacokinetic properties.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;45(3):454-60.
2001: H Luo; N Eberly; R D Rogers; Martin W Brechbiel
Syntheses and characterizations of metal complexes derived from cis,cis-1,3,5-triaminocyclohexane-N,N',N"-triacetic acid.
Inorganic chemistry 2001;40(3):493-8.
2001: Amram Samuni; M Afeworki; William Stein; Alexander T Yordanov; William DeGraff; Murali K Cherukuri; James B Mitchell; Martin W Brechbiel
Multifunctional antioxidant activity of HBED iron chelator.
Free radical biology & medicine 2001;30(2):170-7.
2001: Hisataka Kobayashi; Noriko Sato; Satomi Kawamoto; Tsuneo Saga; Akira Hiraga; T L Haque; Takayoshi Ishimori; Junji Konishi; Kaori Togashi; Martin W Brechbiel
Comparison of the macromolecular MR contrast agents with ethylenediamine-core versus ammonia-core generation-6 polyamidoamine dendrimer.
Bioconjugate chemistry 2001;12(1):100-7.
2000: Stephen J Kennel; Saed Mirzadeh; Gregory B Hurst; Linda J Foote; Trish K Lankford; K A Glowienka; L L Chappell; J R Kelso; Sandra Davern; A Safavy; Martin W Brechbiel
Labeling and distribution of linear peptides identified using in vivo phage display selection for tumors.
Nuclear medicine and biology 2000;27(8):815-25.
2000: Michael R McDevitt; EC Barendswaard; Dangshe Ma; L Lai; Michael J Curcio; George Sgouros; Ase M Ballangrud; Wei-Hong Yang; Ronald D Finn; Virginia A Pellegrini; MW Geerlings; M Lee; Martin W Brechbiel; Neil H Bander; Carlos Cordon-Cardo; David A Scheinberg
An alpha-particle emitting antibody ([213Bi]J591) for radioimmunotherapy of prostate cancer.
Cancer research 2000;60(21):6095-100.
2000: Raya Mandler; Chuanchu Wu; Edward A Sausville; A J Roettinger; David Newman; D K Ho; C R King; D Yang; Marc Lippman; N F Landolfi; Ekaterina Dadachova; Martin W Brechbiel; Thomas Waldmann
Immunoconjugates of geldanamycin and anti-HER2 monoclonal antibodies: antiproliferative activity on human breast carcinoma cell lines.
Journal of the National Cancer Institute 2000;92(19):1573-81.
2000: Hisataka Kobayashi; Noriko Sato; Tsuneo Saga; Yuji Nakamoto; Takayoshi Ishimori; S Toyama; Kaori Togashi; Junji Konishi; Martin W Brechbiel
Monoclonal antibody-dendrimer conjugates enable radiolabeling of antibody with markedly high specific activity with minimal loss of immunoreactivity.
European journal of nuclear medicine 2000;27(9):1334-9.
2000: K Clarke; Fook-Thean Lee; Martin W Brechbiel; Fiona E Smyth; Lloyd J Old; Andrew M Scott
Therapeutic efficacy of anti-Lewis(y) humanized 3S193 radioimmunotherapy in a breast cancer model: enhanced activity when combined with taxol chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(9):3621-8.
2000: K Clarke; Fook-Thean Lee; Martin W Brechbiel; Fiona E Smyth; Lloyd J Old; Andrew M Scott
In vivo biodistribution of a humanized anti-Lewis Y monoclonal antibody (hu3S193) in MCF-7 xenografted BALB/c nude mice.
Cancer research 2000;60(17):4804-11.
2000: Lara L Chappell; KA Deal; Ekaterina Dadachova; Martin W Brechbiel
Synthesis, conjugation, and radiolabeling of a novel bifunctional chelating agent for (225)Ac radioimmunotherapy applications.
Bioconjugate chemistry 2000;11(4):510-9.
2000: Stephen J Kennel; L L Chappell; K Dadachova; Martin W Brechbiel; Trish K Lankford; IA Davis; Michael Stabin; Saed Mirzadeh
Evaluation of 225Ac for vascular targeted radioimmunotherapy of lung tumors.
Cancer biotherapy & radiopharmaceuticals 2000;15(3):235-44.
2000: Raya Mandler; Ekaterina Dadachova; J K Brechbiel; Thomas Waldmann; Martin W Brechbiel
Synthesis and evaluation of antiproliferative activity of a geldanamycin-Herceptin immunoconjugate.
Bioorganic & medicinal chemistry letters 2000;10(10):1025-8.
2000: Gregory P Adams; Calvin Shaller; L L Chappell; Carl Wu; Eva M Horak; Heidi H Simmons; S Litwin; James D Marks; Louis M Weiner; Martin W Brechbiel
Delivery of the alpha-emitting radioisotope bismuth-213 to solid tumors via single-chain Fv and diabody molecules.
Nuclear medicine and biology 2000;27(4):339-46.
2000: Lee Pai-Scherf; Jorge Carrasquillo; Chang H Paik; Otto A Gansow; Millie Whatley; D Pearson; KO Webber; Michael Hamilton; Carmen J Allegra; Martin W Brechbiel; Mark C Willingham; Ira Pastan
Imaging and phase I study of 111In- and 90Y-labeled anti-LewisY monoclonal antibody B3.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1720-30.
2000: Hisataka Kobayashi; C H Kao; Robert J Kreitman; Nhat Le; Meyoung-Kon Kim; Martin W Brechbiel; Chang H Paik; Ira Pastan; Jorge Carrasquillo
Pharmacokinetics of 111In- and 125I-labeled antiTac single-chain Fv recombinant immunotoxin.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2000;41(4):755-62.
2000: Lara L Chappell; Ekaterina Dadachova; Diane E Milenic; Kayhan Garmestani; Chuanchu Wu; Martin W Brechbiel
Synthesis, characterization, and evaluation of a novel bifunctional chelating agent for the lead isotopes 203Pb and 212Pb.
Nuclear medicine and biology 2000;27(1):93-100.
2000: Sheela D Konda; Michael Aref; Martin W Brechbiel; Erik C Wiener
Development of a tumor-targeting MR contrast agent using the high-affinity folate receptor: work in progress.
Investigative radiology 2000;35(1):50-7.
1999: Ekaterina Dadachova; Lara L Chappell; Martin W Brechbiel
Spectrophotometric method for determination of bifunctional macrocyclic ligands in macrocyclic ligand-protein conjugates.
Nuclear medicine and biology 1999;26(8):977-82.
1999: Lara L Chappell; Buck E Rogers; Muhammad B Khazaeli; MS Mayo; Donald J Buchsbaum; Martin W Brechbiel
Improved synthesis of the bifunctional chelating agent 1,4,7,10-tetraaza-N-(1-carboxy-3-(4-nitrophenyl)propyl)-N',N'',N'''-tri s(acetic acid)cyclododecane (PA-DOTA).
Bioorganic & medicinal chemistry 1999;7(11):2313-20.
1999: Donald J Buchsbaum; Buck E Rogers; Muhammad B Khazaeli; MS Mayo; Diane E Milenic; Syed V S Kashmiri; C J Anderson; Lara L Chappell; Martin W Brechbiel; David T Curiel
Targeting strategies for cancer radiotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(10 Suppl):3048s-3055s.
1999: KA Deal; IA Davis; Saed Mirzadeh; Stephen J Kennel; Martin W Brechbiel
Improved in vivo stability of actinium-225 macrocyclic complexes.
Journal of medicinal chemistry 1999;42(15):2988-92.
1999: IA Davis; K A Glowienka; Rose A Boll; KA Deal; Martin W Brechbiel; Michael Stabin; P N Bochsler; Saed Mirzadeh; Stephen J Kennel
Comparison of 225actinium chelates: tissue distribution and radiotoxicity.
Nuclear medicine and biology 1999;26(5):581-9.
1999: M Roselli; Diane E Milenic; Martin W Brechbiel; Saed Mirzadeh; CG Pippin; Otto A Gansow; David Colcher; Jeffrey Schlom
In vivo comparison of CHX-DTPA ligand isomers in athymic mice bearing carcinoma xenografts.
Cancer biotherapy & radiopharmaceuticals 1999;14(3):209-20.
1999: Chuanchu Wu; Otto A Gansow; Martin W Brechbiel
Evaluation of methods for large scale preparation of antibody ligand conjugates.
Nuclear medicine and biology 1999;26(3):339-42.
1999: L Henry Bryant; Martin W Brechbiel; Carl Wu; Jeff W M Bulte; Vit Herynek; Joseph A Frank
Synthesis and relaxometry of high-generation (G = 5, 7, 9, and 10) PAMAM dendrimer-DOTA-gadolinium chelates.
Journal of magnetic resonance imaging : JMRI 1999;9(2):348-52.
1999: Jorge Carrasquillo; Jeffrey D White; Chang H Paik; Andrew Raubitschek; Nhat Le; M Rotman; Martin W Brechbiel; Otto A Gansow; Lois E Top; P Perentesis; James C Reynolds; David L Nelson; Thomas Waldmann
Similarities and differences in 111In- and 90Y-labeled 1B4M-DTPA antiTac monoclonal antibody distribution.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1999;40(2):268-76.
1999: Stephen J Kennel; Michael Stabin; H Yoriyaz; Martin W Brechbiel; Saed Mirzadeh
Treatment of lung tumor colonies with 90Y targeted to blood vessels: comparison with the alpha-particle emitter 213Bi.
Nuclear medicine and biology 1999;26(1):149-57.
1999: Tuomo K Nikula; Michael R McDevitt; Ronald D Finn; Chuanchu Wu; R W Kozak; Kayhan Garmestani; Martin W Brechbiel; Michael J Curcio; CG Pippin; L Tiffany-Jones; MW Geerlings; Christos Apostolidis; Roger Molinet; M W Geerlings; Otto A Gansow; David A Scheinberg
Alpha-emitting bismuth cyclohexylbenzyl DTPA constructs of recombinant humanized anti-CD33 antibodies: pharmacokinetics, bioactivity, toxicity and chemistry.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1999;40(1):166-76.
1999: Hisataka Kobayashi; Carl Wu; M K Kim; Chang H Paik; Jorge Carrasquillo; Martin W Brechbiel
Evaluation of the in vivo biodistribution of indium-111 and yttrium-88 labeled dendrimer-1B4M-DTPA and its conjugation with anti-Tac monoclonal antibody.
Bioconjugate chemistry 1999;10(1):103-11.
1998: Jeff W M Bulte; Carl Wu; Martin W Brechbiel; Rodney A Brooks; J Vymazal; M Holla; Joseph A Frank
Dysprosium-DOTA-PAMAM dendrimers as macromolecular T2 contrast agents. Preparation and relaxometry.
Investigative radiology 1998;33(11):841-5.
1998: T J McMurry; CG Pippin; Chuanchu Wu; KA Deal; Martin W Brechbiel; Saed Mirzadeh; Otto A Gansow
Physical parameters and biological stability of yttrium(III) diethylenetriaminepentaacetic acid derivative conjugates.
Journal of medicinal chemistry 1998;41(18):3546-9.
1998: Suzy V Torti; Frank M Torti; S P Whitman; Martin W Brechbiel; Gyungse Park; Roy P Planalp
Tumor cell cytotoxicity of a novel metal chelator.
Blood 1998;92(4):1384-9.
1998: Hisataka Kobayashi; Chuanchu Wu; Tae M Yoo; BF Sun; D Drumm; Ira Pastan; Chang H Paik; Otto A Gansow; Jorge Carrasquillo; Martin W Brechbiel
Evaluation of the in vivo biodistribution of yttrium-labeled isomers of CHX-DTPA-conjugated monoclonal antibodies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1998;39(5):829-36.
1998: Diane E Milenic; M Roselli; Martin W Brechbiel; CG Pippin; T J McMurray; Jorge Carrasquillo; David Colcher; R Lambrecht; Otto A Gansow; Jeffrey Schlom
In vivo evaluation of a lead-labeled monoclonal antibody using the DOTA ligand.
European journal of nuclear medicine 1998;25(5):471-80.
1997: EM Horak; F Hartmann; Kayhan Garmestani; Chuanchu Wu; Martin W Brechbiel; Otto A Gansow; N F Landolfi; Thomas Waldmann
Radioimmunotherapy targeting of HER2/neu oncoprotein on ovarian tumor using lead-212-DOTA-AE1.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1997;38(12):1944-50.
1997: Erik C Wiener; Sheela D Konda; A Shadron; Martin W Brechbiel; Otto A Gansow
Targeting dendrimer-chelates to tumors and tumor cells expressing the high-affinity folate receptor.
Investigative radiology 1997;32(12):748-54.
1997: Chuanchu Wu; Hisataka Kobayashi; B Sun; Tae M Yoo; Chang H Paik; Otto A Gansow; Jorge Carrasquillo; Ira Pastan; Martin W Brechbiel
Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p-nitrobenzyl)-trans-CyDTPA.
Bioorganic & medicinal chemistry 1997;5(10):1925-34.
1997: Lixin Lang; Elaine M Jagoda; Chuanchu Wu; Martin W Brechbiel; Otto A Gansow; Ira Pastan; Chang H Paik; Jorge Carrasquillo; William Eckelman
Factors influencing the in vivo pharmacokinetics of peptides and antibody fragments: the pharmacokinetics of two PET-labeled low molecular weight proteins.
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) 1997;41(2):53-61.
1997: Martin W Brechbiel; P M Beitzel; Otto A Gansow
Purification of p-nitrobenzyl C-functionalized diethylenetriamine pentaacetic acids for clinical applications using anion-exchange chromatography.
Journal of chromatography. A 1997;771(1-2):63-9.
1997: Chuanchu Wu; E Jagoda; Martin W Brechbiel; KO Webber; Ira Pastan; Otto A Gansow; William Eckelman
Biodistribution and catabolism of Ga-67-labeled anti-Tac dsFv fragment.
Bioconjugate chemistry 1997;8(3):365-9.
1997: J Lee; Kayhan Garmestani; Chuanchu Wu; Martin W Brechbiel; H K Chang; C W Choi; Otto A Gansow; Jorge Carrasquillo; Chang H Paik
In vitro and in vivo evaluation of structure-stability relationship of 111In- and 67Ga-labeled antibody via 1B4M or C-NOTA chelates.
Nuclear medicine and biology 1997;24(3):225-30.
1995: Thomas Waldmann; Jeffrey D White; Jorge Carrasquillo; James C Reynolds; Chang H Paik; Otto A Gansow; Martin W Brechbiel; Elaine S Jaffe; Thomas A Fleisher; Carolyn K Goldman; Lois E Top; RN Bamford; E Zaknoen; E Roessler; C Kasten-Sportes; R England; H Litou; J A Johnson; T Jackson-White; Angela Manns; Barrie Hanchard; Richard P. Junghans; David L Nelson
Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac.
Blood 1995;86(11):4063-75.
1995: T K Nikula; M J Curcio; Martin W Brechbiel; Otto A Gansow; Ronald D Finn; David A Scheinberg
A rapid, single vessel method for preparation of clinical grade ligand conjugated monoclonal antibodies.
Nuclear medicine and biology 1995;22(3):387-90.
1994: S Kinuya; J M Jeong; Kayhan Garmestani; T Saga; L Camera; Martin W Brechbiel; Otto A Gansow; Jorge Carrasquillo; Ronald D Neumann; Chang H Paik
Effect of metabolism on retention of indium-111-labeled monoclonal antibody in liver and blood.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1994;35(11):1851-7.
1994: F Hartmann; E M Horak; Kayhan Garmestani; Chuanchu Wu; Martin W Brechbiel; R W Kozak; J Tso; S A Kosteiny; Otto A Gansow; David L Nelson
Radioimmunotherapy of nude mice bearing a human interleukin 2 receptor alpha-expressing lymphoma utilizing the alpha-emitting radionuclide-conjugated monoclonal antibody 212Bi-anti-Tac.
Cancer research 1994;54(16):4362-70.
1994: L Camera; S Kinuya; Kayhan Garmestani; Martin W Brechbiel; Chuanchu Wu; L H Pai; T J McMurry; Otto A Gansow; Ira Pastan; Chang H Paik
Comparative biodistribution of indium- and yttrium-labeled B3 monoclonal antibody conjugated to either 2-(p-SCN-Bz)-6-methyl-DTPA (1B4M-DTPA) or 2-(p-SCN-Bz)-1,4,7,10-tetraazacyclododecane tetraacetic acid (2B-DOTA).
European journal of nuclear medicine 1994;21(7):640-6.
1994: L Camera; S Kinuya; Kayhan Garmestani; Chuanchu Wu; Martin W Brechbiel; L H Pai; T J McMurry; Otto A Gansow; Ira Pastan; Chang H Paik
Evaluation of the serum stability and in vivo biodistribution of CHX-DTPA and other ligands for yttrium labeling of monoclonal antibodies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1994;35(5):882-9.
1994: E C Wiener; Martin W Brechbiel; H Brothers; Richard L Magin; Otto A Gansow; D A Tomalia; Paul C Lauterbur
Dendrimer-based metal chelates: a new class of magnetic resonance imaging contrast agents.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1994;31(1):1-8.
1993: Richard P. Junghans; D Dobbs; Martin W Brechbiel; Saed Mirzadeh; A A Raubitschek; Otto A Gansow; Thomas Waldmann
Pharmacokinetics and bioactivity of 1,4,7,10-tetra-azacylododecane off',N'',N'''-tetraacetic acid (DOTA)-bismuth-conjugated anti-Tac antibody for alpha-emitter (212Bi) therapy.
Cancer research 1993;53(23):5683-9.
1993: L Camera; S Kinuya; Kayhan Garmestani; L H Pai; Martin W Brechbiel; Otto A Gansow; Chang H Paik; Ira Pastan; Jorge Carrasquillo
Evaluation of a new DTPA-derivative chelator: comparative biodistribution and imaging studies of 111In-labeled B3 monoclonal antibody in athymic mice bearing human epidermoid carcinoma xenografts.
Nuclear medicine and biology 1993;20(8):955-62.
1993: L Camera; S Kinuya; L H Pai; Kayhan Garmestani; Martin W Brechbiel; Otto A Gansow; Chang H Paik; Ira Pastan; Jorge Carrasquillo
Preclinical evaluation of 111In-labeled B3 monoclonal antibody: biodistribution and imaging studies in nude mice bearing human epidermoid carcinoma xenografts.
Cancer research 1993;53(12):2834-9.
1993: T J McMurry; Martin W Brechbiel; Chuanchu Wu; Otto A Gansow
Synthesis of 2-(p-thiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid: application of the 4-methoxy-2,3,6-trimethylbenzenesulfonamide protecting group in the synthesis of macrocyclic polyamines.
Bioconjugate chemistry 1993;4(3):236-45.
1992: G L Parenteau; F M Dirbas; Kayhan Garmestani; Martin W Brechbiel; M A Bukowski; Carolyn K Goldman; R Clark; Otto A Gansow; Thomas Waldmann
Prolongation of graft survival in primate allograft transplantation by yttrium-90-labeled anti-Tac in conjunction with granulocyte colony-stimulating factor.
Transplantation 1992;54(6):963-8.
1992: R B Huneke; CG Pippin; Robert A. Squire; Martin W Brechbiel; Otto A Gansow; M Strand
Effective alpha-particle-mediated radioimmunotherapy of murine leukemia.
Cancer research 1992;52(20):5818-20.
1992: CG Pippin; T A Parker; T J McMurry; Martin W Brechbiel
Spectrophotometric method for the determination of a bifunctional DTPA ligand in DTPA-monoclonal antibody conjugates.
Bioconjugate chemistry 1992;3(4):342-5.
1992: T J McMurry; Martin W Brechbiel; K Kumar; Otto A Gansow
Convenient synthesis of bifunctional tetraaza macrocycles.
Bioconjugate chemistry 1992;3(2):108-17.
1991: Martin W Brechbiel; Otto A Gansow
Backbone-substituted DTPA ligands for 90Y radioimmunotherapy.
Bioconjugate chemistry 1991;2(3):187-94.
1991: Mario Roselli; Jeffrey Schlom; Otto A Gansow; Martin W Brechbiel; Saed Mirzadeh; CG Pippin; Diane E Milenic; David Colcher
Comparative biodistribution studies of DTPA-derivative bifunctional chelates for radiometal labeled monoclonal antibodies.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1991;18(4):389-94.
1990: M M Cooper; R C Robbins; Carolyn K Goldman; Saed Mirzadeh; Martin W Brechbiel; C D Stone; Otto A Gansow; R E Clark; Thomas Waldmann
Use of yttrium-90-labeled anti-Tac antibody in primate xenograft transplantation.
Transplantation 1990;50(5):760-5.
1990: V K Langmuir; R W Atcher; J J Hines; Martin W Brechbiel
Iodine-125-NRLU-10 kinetic studies and bismuth-212-NRLU-10 toxicity in LS174T multicell spheroids.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1990;31(9):1527-33.
1990: J A Greager; T C Chao; Michael J Blend; R W Atcher; Otto A Gansow; Martin W Brechbiel; Tapas K Das Gupta
Localization of pulmonary human sarcoma xenografts in athymic nude mice with indium-111-labeled monoclonal antibodies.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1990;31(8):1378-83.
1990: C L Ruegg; W T Anderson-Berg; Martin W Brechbiel; Saed Mirzadeh; Otto A Gansow; M Strand
Improved in vivo stability and tumor targeting of bismuth-labeled antibody.
Cancer research 1990;50(14):4221-6.
1990: Ban-An Khaw; Otto A Gansow; Martin W Brechbiel; S M O'Donnell; N Nossiff
Use of isothiocyanatobenzyl-DTPA derivatized monoclonal antimyosin fab for enhanced in vivo target localization.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1990;31(2):211-7.
1990: Saed Mirzadeh; Martin W Brechbiel; R W Atcher; Otto A Gansow
Radiometal labeling of immunoproteins: covalent linkage of 2-(4-isothiocyanatobenzyl)diethylenetriaminepentaacetic acid ligands to immunoglobulin.
Bioconjugate chemistry 1990;1(1):59-65.
1989: R W Kozak; A Raubitschek; Saed Mirzadeh; Martin W Brechbiel; Richard P. Junghans; Otto A Gansow; Thomas Waldmann; R Junghaus
Nature of the bifunctional chelating agent used for radioimmunotherapy with yttrium-90 monoclonal antibodies: critical factors in determining in vivo survival and organ toxicity.
Cancer research 1989;49(10):2639-44.
1989: Mario Roselli; Jeffrey Schlom; Otto A Gansow; A Raubitschek; Saed Mirzadeh; Martin W Brechbiel; David Colcher
Comparative biodistributions of yttrium- and indium-labeled monoclonal antibody B72.3 in athymic mice bearing human colon carcinoma xenografts.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1989;30(5):672-82.
1988: Michael J Blend; J A Greager; R W Atcher; J M Brown; Martin W Brechbiel; Otto A Gansow; Tapas K Das Gupta
Improved sarcoma imaging and reduced hepatic activity with indium-111-SCN-Bz-DTPA linked to MoAb 19-24.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1988;29(11):1810-6.
1988: S H Kurtzman; A Russo; James B Mitchell; William DeGraff; W F Sindelar; Martin W Brechbiel; Otto A Gansow; A M Friedman; J J Hines; Janet Gamson
212Bismuth linked to an antipancreatic carcinoma antibody: model for alpha-particle-emitter radioimmunotherapy.
Journal of the National Cancer Institute 1988;80(6):449-52.
1987: J M Esteban; J Schlom; Otto A Gansow; R W Atcher; Martin W Brechbiel; D E Simpson; D Colcher
New method for the chelation of indium-111 to monoclonal antibodies: biodistribution and imaging of athymic mice bearing human colon carcinoma xenografts.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1987;28(5):861-70.
1987: R H Knop; Joseph A Frank; Andrew J Dwyer; M E Girton; M Naegele; M Schrader; J Cobb; Otto A Gansow; M Maegerstadt; Martin W Brechbiel
Gadolinium cryptelates as MR contrast agents.
Journal of computer assisted tomography 1987;11(1):35-42.
1986: Joseph A Frank; Andrew J Dwyer; M Girton; R H Knop; V J Sank; Otto A Gansow; M Magerstadt; Martin W Brechbiel; John L Doppman
Opening of blood-ocular barrier demonstrated by contrast-enhanced MR imaging.
Journal of computer assisted tomography 1986;10(6):912-6.
1986: M Magerstädt; Otto A Gansow; Martin W Brechbiel; D Colcher; L Baltzer; R H Knop; M E Girton; M Naegele
Gd(DOTA): an alternative to Gd(DTPA) as a T1,2 relaxation agent for NMR imaging or spectroscopy.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1986;3(5):808-12.

Register to see more

Copyright © 2011 Elsevier Inc. All rights reserved.