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Shelagh Wilson

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David R Witty; John H Bateson; Guillaume J Hervieu; Phillip Jeffrey; Christopher N Johnson; Alison I Muir; Peter J O'Hanlon; Geoffrey Stemp; Alexander J Stevens; Kevin M Thewlis; Shelagh Wilson; Kim Y Winborn
SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): discovery of antagonist SB-568849.
Gemma K Ford; Kamal A Al-Barazanji; Shelagh Wilson; Declan N C Jones; Michael S Harbuz; David S Jessop
Orexin expression and function: glucocorticoid manipulation, stress, and feeding studies.
Sandra Milasta; Nicholas A Evans; Laura Ormiston; Shelagh Wilson; Robert J Lefkowitz; Graeme Milligan
The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation.

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All Publications

2006: David R Witty; John H Bateson; Guillaume J Hervieu; Phillip Jeffrey; Christopher N Johnson; Alison I Muir; Peter J O'Hanlon; Geoffrey Stemp; Alexander J Stevens; Kevin M Thewlis; Shelagh Wilson; Kim Y Winborn
SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): discovery of antagonist SB-568849.
Bioorganic & medicinal chemistry letters 2006;16(18):4865-71.
2005: Gemma K Ford; Kamal A Al-Barazanji; Shelagh Wilson; Declan N C Jones; Michael S Harbuz; David S Jessop
Orexin expression and function: glucocorticoid manipulation, stress, and feeding studies.
Endocrinology 2005;146(9):3724-31.
2005: Sandra Milasta; Nicholas A Evans; Laura Ormiston; Shelagh Wilson; Robert J Lefkowitz; Graeme Milligan
The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation.
The Biochemical journal 2005;387(Pt 3):573-84.
2004: Jane E Gartlon; Philip G Szekeres; Mark A Pullen; Henry M Sarau; Nambi Aiyar; Usman Shabon; David Michalovich; Klaudia Steplewski; Cathy Ellis; Nabil A Elshourbagy; Mark S Duxon; Tracey E Ashmeade; David C Harrison; Paul R Murdock; Shelagh Wilson; Abdel Ennaceur; Alan R Atkins; Christian A Heidbreder; James Hagan; A Jackie Hunter; Declan N C Jones
Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats.
Psychopharmacology 2004;177(1-2):1-14.
2003: Darren J Moore; Paul R Murdock; Jeannette M Watson; Richard L M Faull; Henry J Waldvogel; Philip G Szekeres; Shelagh Wilson; Katie B Freeman; Piers C Emson
GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function.
Brain research. Molecular brain research 2003;118(1-2):10-23.
2003: Celia P Briscoe; Moh Tadayyon; John L Andrews; William G Benson; Jon K Chambers; Michelle M Eilert; Catherine Ellis; Nabil A Elshourbagy; Aaron S Goetz; Dana T Minnick; Paul R Murdock; Howard R Sauls; Usman Shabon; Lisa D Spinage; Jay C Strum; Philip G Szekeres; Kong B Tan; James M Way; Diane M Ignar; Shelagh Wilson; Alison I Muir
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.
The Journal of biological chemistry 2003;278(13):11303-11.
2003: Andrew J Brown; Susan M Goldsworthy; Ashley A Barnes; Michelle M Eilert; Tcheang Lili; Dion Daniels; Alison I Muir; Mark J Wigglesworth; Ian J Kinghorn; Neil J Fraser; Nicholas B Pike; Jay C Strum; Klaudia Steplewski; Paul R Murdock; Julie C Holder; Fiona Marshall; Philip G Szekeres; Shelagh Wilson; Diane M Ignar; Steven M Foord; Alan Wise; Simon J Dowell
The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.
The Journal of biological chemistry 2003;278(13):11312-9.
2003: Alan Wise; Steven M Foord; Neil J Fraser; Ashley A Barnes; Nabil A Elshourbagy; Michelle M Eilert; Diane M Ignar; Paul R Murdock; Klaudia Steplewski; Andrew Green; Andrew J Brown; Simon J Dowell; Philip G Szekeres; David G Hassall; Fiona Marshall; Shelagh Wilson; Nicholas B Pike
Molecular identification of high and low affinity receptors for nicotinic acid.
The Journal of biological chemistry 2003;278(11):9869-74.
2003: Adam R Kennedy; Jeannie F Todd; Waljit S Dhillo; Leighton J Seal; Mohammad A Ghatei; C P O'Toole; M Jones; David R Witty; K Winborne; G Riley; Guillaume J Hervieu; Shelagh Wilson; Stephen R Bloom
Effect of direct injection of melanin-concentrating hormone into the paraventricular nucleus: further evidence for a stimulatory role in the adrenal axis via SLC-1.
Journal of neuroendocrinology 2003;15(3):268-72.
2002: Hamish J Small; Shelagh Wilson; DM Neil; P Hagan; GH Coombs
Detection of the parasitic dinoflagellate Hematodinium in the Norway lobster Nephrops norvegicus by ELISA.
Diseases of aquatic organisms 2002;52(2):175-7.
2001: K Freeman; Ping Tsui; Darren J Moore; P C Emson; L Vawter; S Naheed; P Lane; H Bawagan; Nicole C Herrity; K Murphy; Henry M Sarau; Robert S Ames; Shelagh Wilson; George P Livi; Jon K Chambers
Cloning, pharmacology, and tissue distribution of G-protein-coupled receptor GPR105 (KIAA0001) rodent orthologs.
Genomics 2001;78(3):124-8.
2001: Alison I Muir; L Chamberlain; Nabil A Elshourbagy; David Michalovich; Darren J Moore; A Calamari; Philip G Szekeres; Henry M Sarau; Jon K Chambers; Paul R Murdock; Klaudia Steplewski; Usman Shabon; JE Miller; S E Middleton; J G Darker; C G Larminie; Shelagh Wilson; DJ Bergsma; Piers C Emson; R Faull; KL Philpott; David C Harrison
AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1.
The Journal of biological chemistry 2001;276(31):28969-75.
2001: jeffrey hill; Malcolm Duckworth; Paul R Murdock; GI Rennie; C Sabido-David; Robert S Ames; Philip G Szekeres; Shelagh Wilson; DJ Bergsma; IS Gloger; D S Levy; Jon K Chambers; Alison I Muir
Molecular cloning and functional characterization of MCH2, a novel human MCH receptor.
The Journal of biological chemistry 2001;276(23):20125-9.
2001: Kamal A Al-Barazanji; Shelagh Wilson; J Baker; David S Jessop; Michael S Harbuz
Central orexin-A activates hypothalamic-pituitary-adrenal axis and stimulates hypothalamic corticotropin releasing factor and arginine vasopressin neurones in conscious rats.
Journal of neuroendocrinology 2001;13(5):421-4.
2001: Mary McVey; Douglas Ramsay; Elaine Kellett; Steven Rees; Shelagh Wilson; Andrew J Pope; Graeme Milligan
Monitoring receptor oligomerization using time-resolved fluorescence resonance energy transfer and bioluminescence resonance energy transfer. The human delta -opioid receptor displays constitutive oligomerization at the cell surface, which is not regulated by receptor occupancy.
The Journal of biological chemistry 2001;276(17):14092-9.
2001: Nicholas A Evans; DA Groarke; J Warrack; C J Greenwood; K Dodgson; Graeme Milligan; Shelagh Wilson
Visualizing differences in ligand-induced beta-arrestin-GFP interactions and trafficking between three recently characterized G protein-coupled receptors.
Journal of neurochemistry 2001;77(2):476-85.
2001: Yuan Zhu; David Michalovich; H Wu; Kong B Tan; GM Dytko; Ishrat J Mannan; Rogely Boyce; J Alston; Lauren A Tierney; X Li; Nicole C Herrity; L Vawter; Henry M Sarau; Robert S Ames; C M Davenport; J Paul Hieble; Shelagh Wilson; DJ Bergsma; LR Fitzgerald
Cloning, expression, and pharmacological characterization of a novel human histamine receptor.
Molecular pharmacology 2001;59(3):434-41.
2001: DA Groarke; T Drmota; Daljit S Bahia; Nicholas A Evans; Shelagh Wilson; Graeme Milligan
Analysis of the C-terminal tail of the rat thyrotropin-releasing hormone receptor-1 in interactions and cointernalization with beta-arrestin 1-green fluorescent protein.
Molecular pharmacology 2001;59(2):375-85.
2000: Nabil A Elshourbagy; Robert S Ames; LR Fitzgerald; James J Foley; Jon K Chambers; Philip G Szekeres; Nicholas A Evans; Dulcie B Schmidt; Peter T Buckley; GM Dytko; Paul R Murdock; Graeme Milligan; DA Groarke; Kong B Tan; Usman Shabon; Parvathi Nuthulaganti; D Y Wang; Shelagh Wilson; DJ Bergsma; Henry M Sarau
Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor.
The Journal of biological chemistry 2000;275(34):25965-71.
2000: LR Fitzgerald; GM Dytko; Henry M Sarau; Ishrat J Mannan; C Ellis; P A Lane; Kong B Tan; Paul R Murdock; Shelagh Wilson; DJ Bergsma; Robert S Ames; James J Foley; D A Campbell; LJ McMillan; N Evans; Nabil A Elshourbagy; H Minehart; Ping Tsui
Identification of an EDG7 variant, HOFNH30, a G-protein-coupled receptor for lysophosphatidic acid.
Biochemical and biophysical research communications 2000;273(3):805-10.
2000: Philip G Szekeres; Alison I Muir; L D Spinage; JE Miller; S I Butler; A Smith; GI Rennie; Paul R Murdock; LR Fitzgerald; H l Wu; LJ McMillan; S Guerrera; L Vawter; Nabil A Elshourbagy; J L Mooney; DJ Bergsma; Shelagh Wilson; Jon K Chambers
Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3.
The Journal of biological chemistry 2000;275(27):20247-50.
2000: Jon K Chambers; L E Macdonald; Henry M Sarau; Robert S Ames; K Freeman; James J Foley; Yuan Zhu; Megan M McLaughlin; Paul R Murdock; LJ McMillan; John J Trill; A Swift; Nambi Aiyar; P Taylor; L Vawter; S Naheed; Philip G Szekeres; Guillaume J Hervieu; C Scott; J M Watson; Andrew J Murphy; E Duzic; C Klein; DJ Bergsma; Shelagh Wilson; George P Livi
A G protein-coupled receptor for UDP-glucose.
The Journal of biological chemistry 2000;275(15):10767-71.
1999: Robert S Ames; Henry M Sarau; Jon K Chambers; Robert N Willette; Nambi Aiyar; Anne M Romanic; CS Louden; James J Foley; Charles F Sauermelch; Robert W Coatney; Zhaohui Ao; Jyoti Disa; S D Holmes; JM Stadel; J D Martin; W S Liu; G I Glover; Shelagh Wilson; Dean E McNulty; CE Ellis; Nabil A Elshourbagy; Usman Shabon; John J Trill; Douglas W P Hay; Eliot ohlstein; DJ Bergsma; Stephen Douglas
Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
Nature 1999;401(6750):282-6.
1999: Henry M Sarau; Robert S Ames; J Chambers; C Ellis; Nabil A Elshourbagy; James J Foley; Dulcie B Schmidt; RM Muccitelli; O Jenkins; Paul R Murdock; Nicole C Herrity; WS Halsey; Ganesh Sathe; Alison I Muir; Parvathi Nuthulaganti; GM Dytko; Peter T Buckley; Shelagh Wilson; DJ Bergsma; Douglas W P Hay
Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor.
Molecular pharmacology 1999;56(3):657-63.
1999: DA Groarke; Shelagh Wilson; C Krasel; Graeme Milligan
Visualization of agonist-induced association and trafficking of green fluorescent protein-tagged forms of both beta-arrestin-1 and the thyrotropin-releasing hormone receptor-1.
The Journal of biological chemistry 1999;274(33):23263-9.
1999: J Chambers; Robert S Ames; DJ Bergsma; A Muir; LR Fitzgerald; Guillaume J Hervieu; GM Dytko; James J Foley; J Martin; W S Liu; J Park; C Ellis; S Ganguly; S Konchar; Jane E Cluderay; R Leslie; Shelagh Wilson; Henry M Sarau
Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.
Nature 1999;400(6741):261-5.
1999: Andrea C Haynes; B Jackson; P Overend; RE Buckingham; Shelagh Wilson; Moh Tadayyon; Jonathan R S Arch
Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat.
Peptides 1999;20(9):1099-105.
1998: Shelagh Wilson; DJ Bergsma; Jon K Chambers; Alison I Muir; K G Fantom; C Ellis; Paul R Murdock; Nicole C Herrity; JM Stadel
Orphan G-protein-coupled receptors: the next generation of drug targets?
British journal of pharmacology 1998;125(7):1387-92.
1998: Andrea C Haynes; Jonathan R S Arch; Shelagh Wilson; S McClue; RE Buckingham
Characterisation of the neuropeptide Y receptor that mediates feeding in the rat: a role for the Y5 receptor?
Regulatory peptides 1998;75-76():355-61.
1998: Takeshi Sakurai; A Amemiya; M Ishii; I Matsuzaki; Richard M Chemelli; Hirokazu Tanaka; S Clay Williams; J A Richarson; gerald paul kozlowski; Shelagh Wilson; Jonathan R S Arch; R E Buckingham; Andrea C Haynes; Steve Carr; Roland S Annan; Dean E McNulty; W S Liu; JA Terrett; Nabil A Elshourbagy; DJ Bergsma; Masashi Yanagisawa
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.
Cell 1998;92(5):1 page following 696.
1998: Takeshi Sakurai; A Amemiya; M Ishii; I Matsuzaki; Richard M Chemelli; Hirokazu Tanaka; S Clay Williams; James A Richardson; gerald paul kozlowski; Shelagh Wilson; Jonathan R S Arch; R E Buckingham; Andrea C Haynes; Steve Carr; Roland S Annan; Dean E McNulty; W S Liu; JA Terrett; Nabil A Elshourbagy; DJ Bergsma; Masashi Yanagisawa
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.
Cell 1998;92(4):573-85.
1997: JM Stadel; Shelagh Wilson; DJ Bergsma
Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery.
Trends in pharmacological sciences 1997;18(11):430-7.
1996: Andrea C Haynes; Kamal A Al-Barazanji; RE Buckingham; Jonathan R S Arch; A L Gott; Steven McClue; Shelagh Wilson
Functional characterisation of the neuropeptide Y receptor mediating feeding in the rat.
Biochemical Society transactions 1996;24(2):286S.