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David Wilton

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TOP 3
Charles N Birts; C Howard Barton; David C Wilton
Catalytic and non-catalytic functions of human IIA phospholipase A2.
Charles N Birts; C Howard Barton; David C Wilton
A catalytically independent physiological function for human acute phase protein group IIA phospholipase A2: cellular uptake facilitates cell debris removal.
Robert M Hagan; Jane Worner-Gibbs; David C Wilton
The interaction of liver fatty-acid-binding protein (FABP) with anionic phospholipid vesicles: is there extended phospholipid anchorage under these conditions?

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All Publications

2010: Charles N Birts; C Howard Barton; David C Wilton
Catalytic and non-catalytic functions of human IIA phospholipase A2.
Trends in biochemical sciences 2010;35(1):28-35.
2008: Charles N Birts; C Howard Barton; David C Wilton
A catalytically independent physiological function for human acute phase protein group IIA phospholipase A2: cellular uptake facilitates cell debris removal.
The Journal of biological chemistry 2008;283(8):5034-45.
2008: Robert M Hagan; Jane Worner-Gibbs; David C Wilton
The interaction of liver fatty-acid-binding protein (FABP) with anionic phospholipid vesicles: is there extended phospholipid anchorage under these conditions?
The Biochemical journal 2008;410(1):123-9.
2007: Anthony D Postle; David C Wilton; Alan N Hunt; George S Attard
Probing phospholipid dynamics by electrospray ionisation mass spectrometry.
Progress in lipid research 2007;46(3-4):200-24.
2005: Robert M Hagan; Jane Worner-Gibbs; David C Wilton
Tryptophan insertion mutagenesis of liver fatty acid-binding protein: L28W mutant provides important insights into ligand binding and physiological function.
The Journal of biological chemistry 2005;280(3):1782-9.
2003: Sabine Beck; Gérard Lambeau; Kristen Scholz-Pedretti; Michael H Gelb; Marcel J W Janssen; Suzanne H Edwards; David C Wilton; Josef Pfeilschifter; Marietta Kaszkin
Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation.
The Journal of biological chemistry 2003;278(32):29799-812.
2003: Stephen A Beers; Andrew G Buckland; Niroshini Giles; Michael H Gelb; David C Wilton
Effect of tryptophan insertions on the properties of the human group IIA phospholipase A2: mutagenesis produces an enzyme with characteristics similar to those of the human group V phospholipase A2.
Biochemistry 2003;42(24):7326-38.
2002: Suzanne H Edwards; Darren Thompson; Sharon F Baker; Steve P Wood; David C Wilton
The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanism.
Biochemistry 2002;41(52):15468-76.
2002: Joanna K Davies; Robert M Hagan; David C Wilton
Effect of charge reversal mutations on the ligand- and membrane-binding properties of liver fatty acid-binding protein.
The Journal of biological chemistry 2002;277(50):48395-402.
2002: Robert M Hagan; Joanna K Davies; David C Wilton
The effect of charge reversal mutations in the alpha-helical region of liver fatty acid binding protein on the binding of fatty-acyl CoAs, lysophospholipids and bile acids.
Molecular and cellular biochemistry 2002;239(1-2):55-60.
2002: Stephen A Beers; Andrew G Buckland; Rao S Koduri; Wonhwa Cho; Michael H Gelb; David C Wilton
The antibacterial properties of secreted phospholipases A2: a major physiological role for the group IIA enzyme that depends on the very high pI of the enzyme to allow penetration of the bacterial cell wall.
The Journal of biological chemistry 2002;277(3):1788-93.
2001: Anthony D Postle; Emma Heeley; David C Wilton
A comparison of the molecular species compositions of mammalian lung surfactant phospholipids.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2001;129(1):65-73.
2000: Andrew G Buckland; David C Wilton
The antibacterial properties of secreted phospholipases A(2).
Biochimica et biophysica acta 2000;1488(1-2):71-82.
2000: Andrew G Buckland; Emma Heeley; David C Wilton
Bacterial cell membrane hydrolysis by secreted phospholipases A(2): a major physiological role of human group IIa sPLA(2) involving both bacterial cell wall penetration and interfacial catalysis.
Biochimica et biophysica acta 2000;1484(2-3):195-206.
2000: Andrew G Buckland; David C Wilton
Anionic phospholipids, interfacial binding and the regulation of cell functions.
Biochimica et biophysica acta 2000;1483(2):199-216.
1999: Joanna K Davies; AE Thumser; David C Wilton
Binding of recombinant rat liver fatty acid-binding protein to small anionic phospholipid vesicles results in ligand release: a model for interfacial binding and fatty acid targeting.
Biochemistry 1999;38(51):16932-40.
1999: Michael H Gelb; Wonhwa Cho; David C Wilton
Interfacial binding of secreted phospholipases A(2): more than electrostatics and a major role for tryptophan.
Current opinion in structural biology 1999;9(4):428-32.
1999: Sang Kyou Han; kwang pyo kim; Rao S Koduri; L Bittova; Nilda Munoz; Alan R Leff; David C Wilton; Michael H Gelb; Wonhwa Cho
Roles of Trp31 in high membrane binding and proinflammatory activity of human group V phospholipase A2.
The Journal of biological chemistry 1999;274(17):11881-8.
1999: M D Bryant; KE Flick; Rao S Koduri; David C Wilton; Barry L Stoddard; Michael H Gelb
1,3-Dioxane-4,6-dione-5-carboxamide-based inhibitors of human group IIA phospholipase A: X-ray structure of the complex and interfacial selection of inhibitors from a structural library.
Bioorganic & medicinal chemistry letters 1999;9(8):1097-102.
1998: Rao S Koduri; Sharon F Baker; Y Snitko; Sang Kyou Han; Wonhwa Cho; David C Wilton; Michael H Gelb
Action of human group IIa secreted phospholipase A2 on cell membranes. Vesicle but not heparinoid binding determines rate of fatty acid release by exogenously added enzyme.
The Journal of biological chemistry 1998;273(48):32142-53.
1998: Sharon F Baker; R Othman; David C Wilton
Tryptophan-containing mutant of human (group IIa) secreted phospholipase A2 has a dramatically increased ability to hydrolyze phosphatidylcholine vesicles and cell membranes.
Biochemistry 1998;37(38):13203-11.
1998: Suzanne H Edwards; Sharon F Baker; David C Wilton
Purification and properties of an active site mutant, H48Q, of human non-pancreatic secreted phospholipase A2.
Biochemical Society transactions 1998;26(3):S239.
1998: Joanna K Davies; AE Thumser; David C Wilton
Liver fatty acid binding protein (FABP) binds to anionic phospholipid vesicles with release of ligand.
Biochemical Society transactions 1998;26(3):S238.
1998: LI Lobo; David C Wilton
Lipoprotein lipase hydrolysis of human lipoproteins measured using a fluorescence displacement assay.
Biochemical Society transactions 1998;26(3):S237.
1998: Andrew G Buckland; David C Wilton
Phospholipase D enhances the hydrolysis of phospholipid vesicles by cytosolic phospholipase A2.
Biochemical Society transactions 1998;26(3):S236.
1998: David C Wilton
Anionic phospholipids and the regulation of cell functions.
Biochemical Society transactions 1998;26(3):378-83.
1998: Y Lin; Farideh Ghomashchi; Robert Nielsen; Y Snitko; Bao-Zhu Yu; S K Han; Wonhwa Cho; David C Wilton; Mahendra K Jain; Bruce H Robinson; Michael H Gelb
Binding of bee venom and human group IIa phospholipases A2 to membranes: a minor role for electrostatics.
Biochemical Society transactions 1998;26(3):341-5.
1998: AE Thumser; Andrew G Buckland; David C Wilton
Monoacylglycerol binding to human serum albumin: evidence that monooleoylglycerol binds at the dansylsarcosine site.
Journal of lipid research 1998;39(5):1033-8.
1998: Andrew G Buckland; David C Wilton
Inhibition of secreted phospholipases A2 by annexin V. Competition for anionic phospholipid interfaces allows an assessment of the relative interfacial affinities of secreted phospholipases A2.
Biochimica et biophysica acta 1998;1391(3):367-76.
1998: AR Kinkaid; R Othman; JE Voysey; David C Wilton
Phospholipase D and phosphatidic acid enhance the hydrolysis of phospholipids in vesicles and in cell membranes by human secreted phospholipase A2.
Biochimica et biophysica acta 1998;1390(2):173-85.
1998: Andrew G Buckland; AR Kinkaid; David C Wilton
Cardiolipin hydrolysis by human phospholipases A2. The multiple enzymatic activities of human cytosolic phospholipase A2.
Biochimica et biophysica acta 1998;1390(1):65-72.
1998: Andrew G Buckland; David C Wilton
Inhibition of human cytosolic phospholipase A2 by human annexin V.
The Biochemical journal 1998;329 ( Pt 2)():369-72.
1997: AR Kinkaid; David C Wilton
The hydrolysis of phosphatidyl-alcohols by phospholipases A2: effect of head group size and polarity.
Biochemical pharmacology 1997;54(12):1331-9.
1997: Y Snitko; Rao S Koduri; Sang Kyou Han; R Othman; Sharon F Baker; B J Molini; David C Wilton; Michael H Gelb; Wonhwa Cho
Mapping the interfacial binding surface of human secretory group IIa phospholipase A2.
Biochemistry 1997;36(47):14325-33.
1997: LI Lobo; David C Wilton
Combined effects of sphingomyelin and cholesterol on the hydrolysis of emulsion particle triolein by lipoprotein lipase.
Biochimica et biophysica acta 1997;1349(2):122-30.
1997: LI Lobo; David C Wilton
Inhibition of lipoprotein lipase activity by tetrahydrolipstatin.
Biochemical Society transactions 1997;25(4):S682.
1997: Andrew G Buckland; David C Wilton
The effect of phosphatidylinositols on cytosolic phospholipase A2 activity using a continuous fluorescent displacement assay.
Biochemical Society transactions 1997;25(4):S599.
1997: Sharon F Baker; David C Wilton
The hydrolysis of biological membranes by secreted phospholipases A.
Biochemical Society transactions 1997;25(4):S598.
1997: AR Kinkaid; David C Wilton
A continuous fluorescence displacement assay for phospholipase D.
Biochemical Society transactions 1997;25(4):S595.
1997: Bao-Zhu Yu; J Rogers; G Ranadive; S Baker; David C Wilton; Rafael Apitz-Castro; Mahendra K Jain
Gossypol modification of Ala-1 of secreted phospholipase A2: a probe for the kinetic effects of sulfate glycoconjugates.
Biochemistry 1997;36(41):12400-11.
1997: AR Kinkaid; JE Voysey; David C Wilton
Cholesterol-3-sulfate enhances phospholipase A2 activity by promoting interfacial binding.
Biochemical Society transactions 1997;25(3):497S.
1997: E Lamura; K Hillier; AR Kinkaid; David C Wilton
Compartmentalisation and characteristics of a Ca2+-dependent phospholipase A2 in human colon mucosa.
Biochemical pharmacology 1997;53(9):1323-32.
1997: AE Thumser; JE Voysey; David C Wilton
A fluorescence displacement assay for the measurement of arachidonoyl ethanolamide (anandamide) and oleoyl amide (octadecenoamide) hydrolysis.
Biochemical pharmacology 1997;53(3):433-5.
1997: LI Lobo; David C Wilton
Effect of lipid composition on lipoprotein lipase activity measured by a continuous fluorescence assay: effect of cholesterol supports an interfacial surface penetration model.
The Biochemical journal 1997;321 ( Pt 3)():829-35.
1996: AE Thumser; David C Wilton
The binding of cholesterol and bile salts to recombinant rat liver fatty acid-binding protein.
The Biochemical journal 1996;320 ( Pt 3)():729-33.
1996: R Othman; S Baker; Y Li; A F Worrall; David C Wilton
Human non-pancreatic (group II) secreted phospholipase A2 expressed from a synthetic gene in Escherichia coli: characterisation of N-terminal mutants.
Biochimica et biophysica acta 1996;1303(2):92-102.
1996: AE Thumser; J Voysey; David C Wilton
Mutations of recombinant rat liver fatty acid-binding protein at residues 102 and 122 alter its structural integrity and affinity for physiological ligands.
The Biochemical journal 1996;314 ( Pt 3)():943-9.
1995: A Creaney; David C Wilton
The effect of dioleoylglycerol on cytosolic phospholipase A2 activity using a continuous fluorescence displacement assay.
Biochemical Society transactions 1995;23(4):569S.
1995: AR Kinkaid; David C Wilton
The effect of anions on interfacial binding and activation of secretory phospholipase A2.
Biochemical Society transactions 1995;23(4):556S.
1995: G C Burdge; A Creaney; Anthony D Postle; David C Wilton
Mammalian secreted and cytosolic phospholipase A2 show different specificities for phospholipid molecular species.
The international journal of biochemistry & cell biology 1995;27(10):1027-32.
1995: W J Man; Y Li; C David O'Connor; David C Wilton
The binding of propionyl-CoA and carboxymethyl-CoA to Escherichia coli citrate synthase.
Biochimica et biophysica acta 1995;1250(1):69-75.
1995: AR Kinkaid; David C Wilton
Enhanced hydrolysis of phosphatidylcholine by human group II non-pancreatic secreted phospholipase A2 as a result of interfacial activation by specific anions. Potential role of cholesterol sulphate.
The Biochemical journal 1995;308 ( Pt 2)():507-12.
1995: AE Thumser; David C Wilton
The binding of natural and fluorescent lysophospholipids to wild-type and mutant rat liver fatty acid-binding protein and albumin.
The Biochemical journal 1995;307 ( Pt 1)():305-11.
1995: A Creaney; D J Masters; M B Needham; R D Gordon; R Mott; David C Wilton
The properties of a cloned human high-molecular-mass cytosolic phospholipase A2 investigated using a continuous fluorescence displacement assay: evidence for enzyme clustering on phospholipid vesicles.
The Biochemical journal 1995;306 ( Pt 3)():857-64.
1994: AE Thumser; J E Voysey; David C Wilton
The binding of lysophospholipids to rat liver fatty acid-binding protein and albumin.
The Biochemical journal 1994;301 ( Pt 3)():801-6.
1994: R Othman; A Worrall; David C Wilton
Some properties of a human group II phospholipase A2 expressed from a synthetic gene in E. coli.
Biochemical Society transactions 1994;22(3):317S.
1994: W J Man; P Tomlinson; David C Wilton
The effect of endotoxin on the activity of group II rat liver phospholipase A2.
Biochemical Society transactions 1994;22(3):316S.
1994: AR Kinkaid; David C Wilton
Comparison of the properties of human group II phospholipase A2 with other secretory phospholipases.
Biochemical Society transactions 1994;22(3):315S.
1994: A Creaney; David C Wilton
A rapid assay for lipocortins using a continuous fluorescence displacement assay for phospholipase A2.
Biochemical Society transactions 1994;22(3):306S.
1994: AE Thumser; David C Wilton
Characterization of binding and structural properties of rat liver fatty-acid-binding protein using tryptophan mutants.
The Biochemical journal 1994;300 ( Pt 3)():827-33.
1994: W J Man; Y Li; C David O'Connor; David C Wilton
The effect of replacing the conserved active-site residues His-264, Asp-312 and Arg-314 on the binding and catalytic properties of Escherichia coli citrate synthase.
The Biochemical journal 1994;300 ( Pt 3)():765-70.
1994: J E Voysey; David C Wilton
Rapid, sensitive fluorometric determination of serum triglyceride by measuring lipase-liberated fatty acids.
Clinical chemistry 1994;40(1):14-7.
1994: AE Thumser; C Evans; A F Worrall; David C Wilton
Effect on ligand binding of arginine mutations in recombinant rat liver fatty acid-binding protein.
The Biochemical journal 1994;297 ( Pt 1)():103-7.
1993: AR Kinkaid; David C Wilton
A continuous fluorescence displacement assay for phospholipase A2 using albumin and medium chain phospholipid substrates.
Analytical biochemistry 1993;212(1):65-70.
1992: M Sheridan; David C Wilton
The binding of the fluorescent ATP analogue 2'(3')-trinitrophenyladenosine-5'-triphosphate to rat liver fatty acid-binding protein.
FEBS letters 1992;314(3):486-8.
1992: Alan N Hunt; AR Kinkaid; David C Wilton; Anthony D Postle
Phospholipase A2 specificities determined in mixed substrate vesicles using a combination of continuous fluorescence displacement and quantitative HPLC analyses.
Biochemical Society transactions 1992;20(3):298S.
1992: W J Man; C David O'Connor; David C Wilton
The effect of an active site mutation of E. coli citrate synthase on NADH inhibition and KCl activation.
Biochemical Society transactions 1992;20(3):291S.
1992: AR Kinkaid; David C Wilton
A study of the 14 kDa phospholipase A2 from rat liver using a continuous fluorescent displacement assay for the enzyme.
Biochemical Society transactions 1992;20(3):287S.
1991: W J Man; Y Li; C David O'Connor; David C Wilton
Conversion of citrate synthase into citryl-CoA lyase as a result of mutation of the active-site aspartic acid residue to glutamic acid.
The Biochemical journal 1991;280 ( Pt 2)():521-6.
1991: AR Kinkaid; David C Wilton
Comparison of the catalytic properties of phospholipase A2 from pancreas and venom using a continuous fluorescence displacement assay.
The Biochemical journal 1991;278 ( Pt 3)():843-8.
1991: A F Worrall; C Evans; David C Wilton
Synthesis of a gene for rat liver fatty-acid-binding protein and its expression in Escherichia coli.
The Biochemical journal 1991;278 ( Pt 2)():365-8.
1991: David C Wilton
A continuous fluorescence-displacement assay for triacylglycerol lipase and phospholipase C that also allows the measurement of acylglycerols.
The Biochemical journal 1991;276 ( Pt 1)():129-33.
1990: C Evans; David C Wilton
The chemical modification of cysteine-69 of rat liver fatty acid-binding protein (FABP): a fluorescence approach to FABP structure and function.
Molecular and cellular biochemistry 1990;98(1-2):135-40.
1990: David C Wilton
The fatty acid analogue 11-(dansylamino)undecanoic acid is a fluorescent probe for the bilirubin-binding sites of albumin and not for the high-affinity fatty acid-binding sites.
The Biochemical journal 1990;270(1):163-6.
1990: David C Wilton
A continuous fluorescence displacement assay for the measurement of phospholipase A2 and other lipases that release long-chain fatty acids.
The Biochemical journal 1990;266(2):435-9.
1989: David C Wilton
Studies on fatty-acid-binding proteins. The purification of rat liver fatty-acid-binding protein and the role of cysteine-69 in fatty acid binding.
The Biochemical journal 1989;261(1):273-6.
1988: P A Handford; S S Ner; D P Bloxham; David C Wilton
Site-directed mutagenesis of citrate synthase; the role of the active-site aspartate in the binding of acetyl-CoA but not oxaloacetate.
Biochimica et biophysica acta 1988;953(3):232-40.
1987: T C Wilkinson; David C Wilton
Studies on fatty acid-binding proteins. The binding properties of rat liver fatty acid-binding protein.
The Biochemical journal 1987;247(2):485-8.
1987: M Sheridan; T C Wilkinson; David C Wilton
Studies on fatty acid-binding proteins. Changes in the concentration of hepatic fatty acid-binding protein during development in the rat.
The Biochemical journal 1987;242(3):919-22.
1987: T C Wilkinson; David C Wilton
Studies on fatty acid-binding proteins. The diurnal variation shown by rat liver fatty acid-binding protein.
The Biochemical journal 1987;242(3):913-7.
1986: T C Wilkinson; David C Wilton
Studies on fatty acid-binding proteins. The detection and quantification of the protein from rat liver by using a fluorescent fatty acid analogue.
The Biochemical journal 1986;238(2):419-24.