FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Klas Wiman

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Genes, p53

Physiology

Anatomy

Living Beings

Mouse

Disorders

Concepts & Ideas

Molecular Sequence Data

Co-author Network

Publications

TOP 3
Ruby Shalom-Feuerstein; Hans van Bokhoven; Klas G Wiman; Huiqing Zhou; Daniel Aberdam; Edith Aberdam; Franz-Josef Müller; Laura Serror; Isabelle Petit
Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET.
Jinfeng Shen; Geuranne S Tjabringa; Hans van Bokhoven; Ellen H van den Bogaard; Simon J van Heeringen; Klas G Wiman; Qiang Zhang; Vladimir J N Bykov; Christian Gilissen; Evelyn N Kouwenhoven; Tuula Rinne; Joost Schalkwijk; Huiqing Zhou
APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations.
Harsha S Madapura; Eva Klein; George Klein; Sonia Lain; Daniel Salamon; Klas G Wiman; Noémi Nagy
p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAP.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Klas Wiman (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Ruby Shalom-Feuerstein; Hans van Bokhoven; Klas G Wiman; Huiqing Zhou; Daniel Aberdam; Edith Aberdam; Franz-Josef Müller; Laura Serror; Isabelle Petit
Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1MET.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(6):2152-6.
2013: Jinfeng Shen; Geuranne S Tjabringa; Hans van Bokhoven; Ellen H van den Bogaard; Simon J van Heeringen; Klas G Wiman; Qiang Zhang; Vladimir J N Bykov; Christian Gilissen; Evelyn N Kouwenhoven; Tuula Rinne; Joost Schalkwijk; Huiqing Zhou
APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(6):2157-62.
2012: Harsha S Madapura; Eva Klein; George Klein; Sonia Lain; Daniel Salamon; Klas G Wiman; Noémi Nagy
p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAP.
Cell cycle (Georgetown, Tex.) 2012;11(24):4563-9.
2012: Sören Lehmann; Ali Moshfegh; Christer Paul; Ulf Tidefelt; Bertil Uggla; Klas G Wiman; Jeffrey Yachnin; Ove Andrén; Vladimir J N Bykov; Honar Cherif; Gunnar Juliusson; Dina Ali; Per-Ola Andersson
Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(29):3633-9.
2011: A Vilborg; Margareta T Wilhelm; C Bersani; Klas G Wiman
The p53 target Wig-1: a regulator of mRNA stability and stem cell fate?
Cell death and differentiation 2011;18(9):1434-40.
2010: N Rökaeus; J Shen; I Eckhardt; V J N Bykov; Klas G Wiman; M T Wilhelm
PRIMA-1(MET)/APR-246 targets mutant forms of p53 family members p63 and p73.
Oncogene 2010;29(49):6442-51.
2010: Doriane A Gouas; Hong Shi; Agnès H Hautefeuille; Sandra L Ortiz-Cuaran; Pénélope C Legros; Katarzyna J Szymanska; Olivier Galy; Lars A Egevad; Behnoush Abedi-Ardekani; Klas G Wiman; Olivier Hantz; Claude Caron de Fromentel; Isabelle A Chemin; Pierre L Hainaut
Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: interaction with hepatitis B virus X protein.
Carcinogenesis 2010;31(8):1475-82.
2010: Klas G Wiman
Pharmacological reactivation of mutant p53: from protein structure to the cancer patient.
Oncogene 2010;29(30):4245-52.
2010: Anna Vilborg; Margareta T Wilhelm; Klas G Wiman
Regulation of tumor suppressor p53 at the RNA level.
Journal of molecular medicine (Berlin, Germany) 2010;88(7):645-52.
2010: Masoud Karimi; Francesca Conserva; Salah Mahmoudi; Jan Bergman; Klas G Wiman; Vladimir J N Bykov
Extract from Asteraceae Brachylaena ramiflora induces apoptosis preferentially in mutant p53-expressing human tumor cells.
Carcinogenesis 2010;31(6):1045-53.
2010: Marianne Farnebo; Vladimir J N Bykov; Klas G Wiman
The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancer.
Biochemical and biophysical research communications 2010;396(1):85-9.
2010: J M R Lambert; A Moshfegh; Pierre Hainaut; Klas G Wiman; V J N Bykov
Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis.
Oncogene 2010;29(9):1329-38.
2010: Salah Mahmoudi; Sofia Henriksson; Irene Weibrecht; Stephen Smith; Ola Söderberg; Staffan Strömblad; Klas G Wiman; Marianne Farnebo
WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies.
PLoS biology 2010;8(11):e1000521.
2009: Anna Vilborg; Jacob A Glahder; Margareta T Wilhelm; Cinzia Bersani; Martin Corcoran; Salah Mahmoudi; Maiken Rosenstierne; Dan Grandér; Marianne Farnebo; Bodil Norrild; Klas G Wiman
The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(37):15756-61.
2009: Pierre Hainaut; Klas G Wiman
30 years and a long way into p53 research.
The lancet oncology 2009;10(9):913-9.
2009: Esbjörn Paul; Esbjörn Paul; Bertil Uggla; Stefan Deneberg; Sofia Bengtzen; Monica Hermansson; Ingrid Dahlman; Richard Rosenquist; Klas G Wiman; Hareth Nahi
Low p14ARF expression in de novo acute myeloid leukemia with normal karyotype is associated with poor survival.
Leukemia & lymphoma 2009;50(9):1512-8.
2009: Vladimir J N Bykov; Jeremy M R Lambert; Pierre Hainaut; Klas G Wiman
Mutant p53 rescue and modulation of p53 redox state.
Cell cycle (Georgetown, Tex.) 2009;8(16):2509-17.
2009: Jeremy M R Lambert; Petr Gorzov; Dimitry B Veprintsev; Maja Söderqvist; Dan Segerbäck; Jan Bergman; Alan Fersht; Pierre Hainaut; Klas G Wiman; Vladimir J N Bykov
PRIMA-1 reactivates mutant p53 by covalent binding to the core domain.
Cancer cell 2009;15(5):376-88.
2009: Xin Wang; Anna Zhenchuk; Klas G Wiman; Freidoun Albertioni
Regulation of p53R2 and its role as potential target for cancer therapy.
Cancer letters 2009;276(1):1-7.
2009: Salah Mahmoudi; Sofia Henriksson; Martin Corcoran; Cristina Méndez-Vidal; Klas G Wiman; Marianne Farnebo
Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage.
Molecular cell 2009;33(4):462-71.
2009: György Stuber; Emilie Flaberg; Gabor Petranyi; Rita Otvös; Nina Rökaeus; Elena Kashuba; Klas G Wiman; George Klein; Laszlo Szekely
PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein.
Molecular cancer 2009;8():23.
2008: J Shen; H Vakifahmetoglu; Helene Stridh; Boris Zhivotovsky; Klas G Wiman
PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2.
Oncogene 2008;27(51):6571-80.
2008: R Rahman-Roblick; U Hellman; S Becker; F G Bader; Gert Auer; Klas G Wiman; U J Roblick
Proteomic identification of p53-dependent protein phosphorylation.
Oncogene 2008;27(35):4854-9.
2008: Hong Shi; Jeremy M R Lambert; Agnès Hautefeuille; Vladimir Bykov; Klas G Wiman; Pierre Hainaut; Claude Caron de Fromentel
In vitro and in vivo cytotoxic effects of PRIMA-1 on hepatocellular carcinoma cells expressing mutant p53ser249.
Carcinogenesis 2008;29(7):1428-34.
2008: Magdalena Prahl; Anna Vilborg; Carina Palmberg; Hans Jörnvall; Charlotte Asker; Klas G Wiman
The p53 target protein Wig-1 binds hnRNP A2/B1 and RNA Helicase A via RNA.
FEBS letters 2008;582(15):2173-7.
2008: Nicole Zache; Jeremy M R Lambert; Nina Rökaeus; Jinfeng Shen; Pierre Hainaut; Jan Bergman; Klas G Wiman; Vladimir J N Bykov
Mutant p53 targeting by the low molecular weight compound STIMA-1.
Molecular oncology 2008;2(1):70-80.
2008: Hareth Nahi; Galina Selivanova; S Lehmann; Lars Möllgård; S Bengtzen; H Concha; A Svensson; Klas G Wiman; Mats Merup; Christer Paul
Mutated and non-mutated TP53 as targets in the treatment of leukaemia.
British journal of haematology 2008;141(4):445-53.
2008: Nicole Zache; Jeremy M R Lambert; Klas G Wiman; Vladimir Bykov
PRIMA-1MET inhibits growth of mouse tumors carrying mutant p53.
Cellular oncology : the official journal of the International Society for Cellular Oncology 2008;30(5):411-8.
2007: thierry soussi; Klas G Wiman
Shaping genetic alterations in human cancer: the p53 mutation paradigm.
Cancer cell 2007;12(4):303-12.
2007: Galina Selivanova; Klas G Wiman
Reactivation of mutant p53: molecular mechanisms and therapeutic potential.
Oncogene 2007;26(15):2243-54.
2007: Rubaiyat Rahman-Roblick; Uwe Johannes Roblick; Ulf Hellman; Paolo Conrotto; Tao Liu; Susanne Becker; Hirschberg Daniel; Hans Jörnvall; Gert Auer; Klas G Wiman
p53 targets identified by protein expression profiling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(13):5401-6.
2007: T Liu; C Laurell; Galina Selivanova; J Lundeberg; Peter Nilsson; Klas G Wiman
Hypoxia induces p53-dependent transactivation and Fas/CD95-dependent apoptosis.
Cell death and differentiation 2007;14(3):411-21.
2007: N Rökaeus; George Klein; Klas G Wiman; Laszlo Szekely; Karin Mattsson
PRIMA-1(MET) induces nucleolar accumulation of mutant p53 and PML nuclear body-associated proteins.
Oncogene 2007;26(7):982-92.
2007: Klas G Wiman
Restoration of wild-type p53 function in human tumors: strategies for efficient cancer therapy.
Advances in cancer research 2007;97():321-38.
2006: Cristina Méndez-Vidal; Magdalena Prahl; Klas G Wiman
The p53-induced Wig-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs.
FEBS letters 2006;580(18):4401-8.
2006: Klas G Wiman
Strategies for therapeutic targeting of the p53 pathway in cancer.
Cell death and differentiation 2006;13(6):921-6.
2006: Hareth Nahi; Mats Merup; S Lehmann; S Bengtzen; L Möllgård; Galina Selivanova; Klas G Wiman; Christer Paul
PRIMA-1 induces apoptosis in acute myeloid leukaemia cells with p53 gene deletion.
British journal of haematology 2006;132(2):230-6.
2005: Vladimir Bykov; Natalia Issaeva; Nicole Zache; Alexandre Shilov; Monica Hultcrantz; Jan Bergman; Galina Selivanova; Klas G Wiman
Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.
The Journal of biological chemistry 2005;280(34):30384-91.
2005: Vladimir Bykov; Nicole Zache; Helene Stridh; Jacob Westman; Jan Bergman; Galina Selivanova; Klas G Wiman
PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis.
Oncogene 2005;24(21):3484-91.
2005: Rubaiyat Rahman; Leena Latonen; Klas G Wiman
hTERT antagonizes p53-induced apoptosis independently of telomerase activity.
Oncogene 2005;24(8):1320-7.
2004: Hareth Nahi; S Lehmann; L Mollgard; S Bengtzen; Galina Selivanova; Klas G Wiman; Christer Paul; Mats Merup
Effects of PRIMA-1 on chronic lymphocytic leukaemia cells with and without hemizygous p53 deletion.
British journal of haematology 2004;127(3):285-91.
2004: Fredrik Hellborg; Klas G Wiman
The p53-induced Wig-1 zinc finger protein is highly conserved from fish to man.
International journal of oncology 2004;24(6):1559-64.
2003: Natalia Issaeva; Assaf Friedler; Przemyslaw Bozko; Klas G Wiman; Alan Fersht; Galina Selivanova
Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13303-7.
2003: Vladimir Bykov; Galina Selivanova; Klas G Wiman
Small molecules that reactivate mutant p53.
European journal of cancer (Oxford, England : 1990) 2003;39(13):1828-34.
2003: Mikael Lindström; Klas G Wiman
Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts.
Oncogene 2003;22(32):4993-5005.
2003: Vladimir Bykov; Klas G Wiman
Novel cancer therapy by reactivation of the p53 apoptosis pathway.
Annals of medicine 2003;35(7):458-65.
2002: Vladimir Bykov; Natalia Issaeva; Galina Selivanova; Klas G Wiman
Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.
Carcinogenesis 2002;23(12):2011-8.
2002: Mikael Lindström; Klas G Wiman
Role of genetic and epigenetic changes in Burkitt lymphoma.
Seminars in cancer biology 2002;12(5):381-7.
2002: Maria Hägg; Kenneth Bivén; Takayuki Ueno; Lars Rydlander; Peter Björklund; Klas G Wiman; Maria C Shoshan; Stig Linder
A novel high-through-put assay for screening of pro-apoptotic drugs.
Investigational new drugs 2002;20(3):253-9.
2002: Margareta T Wilhelm; Cristina Méndez-Vidal; Klas G Wiman
Identification of functional p53-binding motifs in the mouse wig-1 promoter.
FEBS letters 2002;524(1-3):69-72.
2002: Jamileh Hashemi; Mikael Lindström; Charlotte Asker; Anton Platz; Johan Hansson; Klas G Wiman
A melanoma-predisposing germline CDKN2A mutation with functional significance for both p16 and p14ARF.
Cancer letters 2002;180(2):211-21.
2002: Cristina Méndez-Vidal; Margareta T Wilhelm; Fredrik Hellborg; Wang Qian; Klas G Wiman
The p53-induced mouse zinc finger protein wig-1 binds double-stranded RNA with high affinity.
Nucleic acids research 2002;30(9):1991-6.
2002: Thomas M Rippin; Vladimir Bykov; Stefan M V Freund; Galina Selivanova; Klas G Wiman; Alan Fersht
Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.
Oncogene 2002;21(14):2119-29.
2002: Vladimir Bykov; Natalia Issaeva; Alexandre Shilov; Monica Hultcrantz; Elena Pugacheva; Peter Chumakov; Jan Bergman; Klas G Wiman; Galina Selivanova
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.
Nature medicine 2002;8(3):282-8.
2001: Fredrik Hellborg; W Qian; C Mendez-Vidal; Charlotte Asker; Maria Kost-Alimova; M Wilhelm; Stefan Imreh; Klas G Wiman
Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein.
Oncogene 2001;20(39):5466-74.
2001: Mikael Lindström; U Klangby; Klas G Wiman
p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53.
Oncogene 2001;20(17):2171-7.
2001: M Nakamura; T Watanabe; U Klangby; Charlotte Asker; Klas G Wiman; Yasuhiro Yonekawa; Paul Kleihues; Hiroko Ohgaki
p14ARF deletion and methylation in genetic pathways to glioblastomas.
Brain pathology (Zurich, Switzerland) 2001;11(2):159-68.
2001: Marie Henriksson; Galina Selivanova; M Lindström; Klas G Wiman
Inactivation of Myc-induced p53-dependent apoptosis in human tumors.
Apoptosis : an international journal on programmed cell death 2001;6(1-2):133-7.
2000: Dawei Xu; Q Wang; Astrid Gruber; Magnus Björkholm; Z Chen; A Zaid; Galina Selivanova; C Peterson; Klas G Wiman; P Pisa
Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells.
Oncogene 2000;19(45):5123-33.
2000: Mikael Lindström; U Klangby; R Inoue; P Pisa; Klas G Wiman; Charlotte Asker
Immunolocalization of human p14(ARF) to the granular component of the interphase nucleolus.
Experimental cell research 2000;256(2):400-10.
2000: Kristinn Magnusson; M Sandström; M Ståhlberg; M Larsson; Jenny Flygare; D Hellgren; Klas G Wiman; S Ljungquist
p53 splice acceptor site mutation and increased HsRAD51 protein expression in Bloom's syndrome GM1492 fibroblasts.
Gene 2000;246(1-2):247-54.
2000: W Qian; Klas G Wiman
Polyoma virus middle T and small t antigens cooperate to antagonize p53-induced cell cycle arrest and apoptosis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000;11(1):31-9.
1999: Charlotte Asker; Klas G Wiman; Galina Selivanova
p53-induced apoptosis as a safeguard against cancer.
Biochemical and biophysical research communications 1999;265(1):1-6.
1999: R Inoue; Charlotte Asker; U Klangby; P Pisa; Klas G Wiman
Induction of the human ARF protein by serum starvation.
Anticancer research 1999;19(4B):2939-43.
1999: Galina Selivanova; L Ryabchenko; E Jansson; V Iotsova; Klas G Wiman
Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.
Molecular and cellular biology 1999;19(5):3395-402.
1998: Klas G Wiman
New p53-based anti-cancer therapeutic strategies.
Medical oncology (Northwood, London, England) 1998;15(4):222-8.
1998: Kristinn Magnusson; R Satalino; W Qian; George Klein; Klas G Wiman
Is conversion of solid into more anoxic ascites tumors associated with p53 inactivation?
Oncogene 1998;17(18):2333-7.
1998: U Klangby; I Okan; Kristinn Magnusson; M Wendland; P Lind; Klas G Wiman
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Blood 1998;91(5):1680-7.
1998: Galina Selivanova; T Kawasaki; L Ryabchenko; Klas G Wiman
Reactivation of mutant p53: a new strategy for cancer therapy.
Seminars in cancer biology 1998;8(5):369-78.
1997: S Varmeh-Ziaie; I Okan; Y Wang; Kristinn Magnusson; P Warthoe; M Strauss; Klas G Wiman
Wig-1, a new p53-induced gene encoding a zinc finger protein.
Oncogene 1997;15(22):2699-704.
1997: Klas G Wiman
p53: emergency brake and target for cancer therapy.
Experimental cell research 1997;237(1):14-8.
1997: Galina Selivanova; V Iotsova; I Okan; Michael Fritsche; M Ström; B Groner; R C Grafström; Klas G Wiman
Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain.
Nature medicine 1997;3(6):632-8.
1997: W Qian; Elena Kashuba; Kristinn Magnusson; Katja Pokrovskaja; I Okan; George Klein; Klas G Wiman
Role of p53 mutation in polyomavirus-induced tumorigenesis.
The Journal of general virology 1997;78 ( Pt 4)():893-903.
1996: Katja Pokrovskaja; Barbro Ehlin-Henriksson; J Bartkova; J Bartek; R Scuderi; Laszlo Szekely; Klas G Wiman; George Klein
Phenotype-related differences in the expression of D-type cyclins in human B cell-derived lines.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(12):1723-32.
1996: Galina Selivanova; V Iotsova; E Kiseleva; M Ström; Georgy Bakalkin; Roland C Grafström; Klas G Wiman
The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.
Nucleic acids research 1996;24(18):3560-7.
1996: Olle Sangfelt; Stefan Einhorn; A C Björklund; Klas G Wiman; I Okan; Dan Grandér
Wild-type p53-induced apoptosis in a Burkitt lymphoma cell line is inhibited by interferon gamma.
International journal of cancer. Journal international du cancer 1996;67(1):106-12.
1996: Y Wang; I Okan; Katja Pokrovskaja; Klas G Wiman
Abrogation of p53-induced G1 arrest by the HPV 16 E7 protein does not inhibit p53-induced apoptosis.
Oncogene 1996;12(12):2731-5.
1996: Yoshihiko Tomita; Vladimir Bilim; T Kawasaki; Kota Takahashi; I Okan; Kristinn Magnusson; Klas G Wiman
Frequent expression of Bcl-2 in renal-cell carcinomas carrying wild-type p53.
International journal of cancer. Journal international du cancer 1996;66(3):322-5.
1996: R Scuderi; Karolina A Palucka; Katja Pokrovskaja; Magnus Björkholm; Klas G Wiman; Pavel Pisa
Cyclin E overexpression in relapsed adult acute lymphoblastic leukemias of B-cell lineage.
Blood 1996;87(8):3360-7.
1995: Charlotte Asker; Kristinn Magnusson; Steven Piccoli; K Andersson; George Klein; Michael D Cole; Klas G Wiman
Mouse and rat B-myc share amino acid sequence homology with the c-myc transcriptional activator domain and contain a B-myc specific carboxy terminal region.
Oncogene 1995;11(10):1963-9.
1995: Laszlo Szekely; W Q Jiang; Katja Pokrovskaja; Klas G Wiman; George Klein; NR Ringertz
Reversible nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 and hsp70 proteins after exposure to heat shock or cell density congestion.
The Journal of general virology 1995;76 ( Pt 10)():2423-32.
1995: P S Kulkarni; K Sundqvist; C Betsholtz; P Höglund; Klas G Wiman; B Zhivotovsky; F Bertolero; Y Liu; Roland C Grafström
Characterization of human buccal epithelial cells transfected with the simian virus 40 T-antigen gene.
Carcinogenesis 1995;16(10):2515-21.
1995: I Okan; Y Wang; F Chen; L F Hu; Stefan Imreh; George Klein; Klas G Wiman
The EBV-encoded LMP1 protein inhibits p53-triggered apoptosis but not growth arrest.
Oncogene 1995;11(6):1027-31.
1995: Kristinn Magnusson; J Minarovits; George Klein; Klas G Wiman
A splice donor site mutation results in the insertion of five extra amino acids into P53 from SEWA mouse sarcoma cells.
Gene 1995;162(2):231-4.
1995: Y Wang; I Okan; Laszlo Szekely; George Klein; Klas G Wiman
bcl-2 inhibits wild-type p53-triggered apoptosis but not G1 cell cycle arrest and transactivation of WAF1 and bax.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(9):1071-5.
1995: Laszlo Szekely; Y Wang; George Klein; Klas G Wiman
RB-reconstituted human retinoblastoma cells form RB-positive intraocular and intracerebral but not subcutaneous tumors in SCID mice.
International journal of cancer. Journal international du cancer 1995;61(5):683-91.
1995: Laszlo Szekely; Katja Pokrovskaja; W Q Jiang; Galina Selivanova; M Löwbeer; NR Ringertz; Klas G Wiman; George Klein
Resting B-cells, EBV-infected B-blasts and established lymphoblastoid cell lines differ in their Rb, p53 and EBNA-5 expression patterns.
Oncogene 1995;10(9):1869-74.
1995: Georgy Bakalkin; Galina Selivanova; Tatiana Yakovleva; E Kiseleva; Elena Kashuba; Kristinn Magnusson; Laszlo Szekely; George Klein; Lars Terenius; Klas G Wiman
p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain.
Nucleic acids research 1995;23(3):362-9.
1995: Galina Selivanova; Klas G Wiman
p53: a cell cycle regulator activated by DNA damage.
Advances in cancer research 1995;66():143-80.
1994: M Aguilar-Santelises; Kristinn Magnusson; Klas G Wiman; Håkan Mellstedt; M Jondal
Progressive B-cell chronic lymphocytic leukaemia frequently exhibits aberrant p53 expression.
International journal of cancer. Journal international du cancer 1994;58(4):474-9.
1994: Pierre Savatier; S Huang; Laszlo Szekely; Klas G Wiman; Jacques Samarut
Contrasting patterns of retinoblastoma protein expression in mouse embryonic stem cells and embryonic fibroblasts.
Oncogene 1994;9(3):809-18.
1994: Georgy Bakalkin; Tatiana Yakovleva; Galina Selivanova; Kristinn Magnusson; Laszlo Szekely; E Kiseleva; George Klein; Lars Terenius; Klas G Wiman
p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):413-7.
1993: Y Wang; Laszlo Szekely; I Okan; George Klein; Klas G Wiman
Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma line.
Oncogene 1993;8(12):3427-31.
1993: Klas G Wiman
The retinoblastoma gene: role in cell cycle control and cell differentiation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(10):841-5.
1993: Laszlo Szekely; Galina Selivanova; Kristinn Magnusson; George Klein; Klas G Wiman
EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(12):5455-9.
1993: T Ramqvist; Kristinn Magnusson; Y Wang; Laszlo Szekely; George Klein; Klas G Wiman
Wild-type p53 induces apoptosis in a Burkitt lymphoma (BL) line that carries mutant p53.
Oncogene 1993;8(6):1495-500.
1993: Y Wang; T Ramqvist; Laszlo Szekely; H Axelson; George Klein; Klas G Wiman
Reconstitution of wild-type p53 expression triggers apoptosis in a p53-negative v-myc retrovirus-induced T-cell lymphoma line.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1993;4(6):467-73.
1993: Laszlo Szekely; P Jin; W Q Jiang; A Rosén; Klas G Wiman; George Klein; NR Ringertz
Position-dependent nuclear accumulation of the retinoblastoma (RB) protein during in vitro myogenesis.
Journal of cellular physiology 1993;155(2):313-22.
1992: Laszlo Szekely; W Q Jiang; Floriana Bulic-Jakus; A Rosen; NR Ringertz; George Klein; Klas G Wiman
Cell type and differentiation dependent heterogeneity in retinoblastoma protein expression in SCID mouse fetuses.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992;3(3):149-56.
1991: Klas G Wiman; Kristinn Magnusson; T Ramqvist; George Klein
Mutant p53 detected in a majority of Burkitt lymphoma cell lines by monoclonal antibody PAb240.
Oncogene 1991;6(9):1633-9.
1991: Laszlo Szekely; Eva Uzvolgyi; W Q Jiang; M Durko; Klas G Wiman; George Klein; Janos Sumegi
Subcellular localization of the retinoblastoma protein.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(6):287-95.