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Eckard Wimmer

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Nusrat Jahan; Eckard Wimmer; Steffen Mueller
Polypyrimidine Tract Binding Protein-1 (PTB1) Is a Determinant of the Tissue and Host Tropism of a Human Rhinovirus/Poliovirus Chimera PV1(RIPO).
Yutong Song; Charles B Ward; Bruce Futcher; Ying Liu; Steffen Mueller; Aniko V Paul; Steven Skiena; Eckard Wimmer
Identification of two functionally redundant RNA elements in the coding sequence of poliovirus using computer-generated design.
Chunling Wang; Ping Jiang; Aniko V Paul; Claire Sand; Eckard Wimmer
Alanine scanning of poliovirus 2CATPase reveals new genetic evidence that capsid protein/2CATPase interactions are essential for morphogenesis.

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2013: Nusrat Jahan; Eckard Wimmer; Steffen Mueller
Polypyrimidine Tract Binding Protein-1 (PTB1) Is a Determinant of the Tissue and Host Tropism of a Human Rhinovirus/Poliovirus Chimera PV1(RIPO).
PloS one 2013;8(4):e60791.
2012: Yutong Song; Charles B Ward; Bruce Futcher; Ying Liu; Steffen Mueller; Aniko V Paul; Steven Skiena; Eckard Wimmer
Identification of two functionally redundant RNA elements in the coding sequence of poliovirus using computer-generated design.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(36):14301-7.
2012: Chunling Wang; Ping Jiang; Aniko V Paul; Claire Sand; Eckard Wimmer
Alanine scanning of poliovirus 2CATPase reveals new genetic evidence that capsid protein/2CATPase interactions are essential for morphogenesis.
Journal of virology 2012;86(18):9964-75.
2011: Varsha Sitaraman; Steven Skiena; Charles B Ward; Eckard Wimmer; Dmitri V Gnatenko; Patrick Hearing; Steffen Mueller; Wadie F Bahou
Computationally designed adeno-associated virus (AAV) Rep 78 is efficiently maintained within an adenovirus vector.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(34):14294-9.
2011: Nusrat Jahan; Eckard Wimmer; Steffen Mueller
A host-specific, temperature-sensitive translation defect determines the attenuation phenotype of a human rhinovirus/poliovirus chimera, PV1(RIPO).
Journal of virology 2011;85(14):7225-35.
2011: Eckard Wimmer; Aniko V Paul
Synthetic poliovirus and other designer viruses: what have we learned from them?
Annual review of microbiology 2011;65():583-609.
2011: Hidemi Toyoda; Eckard Wimmer; Jeronimo Cello
Oncolytic poliovirus therapy and immunization with poliovirus-infected cell lysate induces potent antitumor immunity against neuroblastoma in vivo.
International journal of oncology 2011;38(1):81-7.
2010: Steffen Mueller; J. Robert Coleman; Dimitris Papamichail; Charles B Ward; Anjaruwee Nimnual; Bruce Futcher; Steven Skiena; Eckard Wimmer
Live attenuated influenza virus vaccines by computer-aided rational design.
Nature biotechnology 2010;28(7):723-6.
2010: Ying Liu; Chunling Wang; Steffen Mueller; Aniko V Paul; Eckard Wimmer; Ping Jiang
Direct interaction between two viral proteins, the nonstructural protein 2C and the capsid protein VP3, is required for enterovirus morphogenesis.
PLoS pathogens 2010;6(8):e1001066.
2009: Eckard Wimmer; Steffen Mueller; Terrence M Tumpey; Jeffery K Taubenberger
Synthetic viruses: a new opportunity to understand and prevent viral disease.
Nature biotechnology 2009;27(12):1163-72.
2009: Ying Liu; Eckard Wimmer; Aniko V Paul
Cis-acting RNA elements in human and animal plus-strand RNA viruses.
Biochimica et biophysica acta 2009;1789(9-10):495-517.
2009: Steffen Mueller; J. Robert Coleman; Eckard Wimmer
Putting synthesis into biology: a viral view of genetic engineering through de novo gene and genome synthesis.
Chemistry & biology 2009;16(3):337-47.
2008: Ping Zhang; Steffen Mueller; Marc C Morais; Carol M Bator; valorie bowman; Susan Hafenstein; Eckard Wimmer; Michael G Rossmann
Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18284-9.
2008: Shaukat Khan; Xiaozhong Peng; Jiang Yin; Ping Zhang; Eckard Wimmer
Characterization of the New World monkey homologues of human poliovirus receptor CD155.
Journal of virology 2008;82(14):7167-79.
2008: J. Robert Coleman; Dimitris Papamichail; Steven Skiena; Bruce Futcher; Eckard Wimmer; Steffen Mueller
Virus attenuation by genome-scale changes in codon pair bias.
Science (New York, N.Y.) 2008;320(5884):1784-7.
2008: Jeronimo Cello; Hidemi Toyoda; Nidia Dejesus; Elena Y Dobrikova; Matthias Gromeier; Eckard Wimmer
Growth phenotypes and biosafety profiles in poliovirus-receptor transgenic mice of recombinant oncolytic polio/human rhinoviruses.
Journal of medical virology 2008;80(2):352-9.
2007: Hidemi Toyoda; David Franco; Kentaro Fujita; Aniko V Paul; Eckard Wimmer
Replication of poliovirus requires binding of the poly(rC) binding protein to the cloverleaf as well as to the adjacent C-rich spacer sequence between the cloverleaf and the internal ribosomal entry site.
Journal of virology 2007;81(18):10017-28.
2007: Jiang Yin; Ying Liu; Eckard Wimmer; Aniko V Paul
Complete protein linkage map between the P2 and P3 non-structural proteins of poliovirus.
The Journal of general virology 2007;88(Pt 8):2259-67.
2007: Ying Liu; David Franco; Aniko V Paul; Eckard Wimmer
Tyrosine 3 of poliovirus terminal peptide VPg(3B) has an essential function in RNA replication in the context of its precursor protein, 3AB.
Journal of virology 2007;81(11):5669-84.
2007: Ping Jiang; Johan A J Faase; Hidemi Toyoda; Aniko Paul; Eckard Wimmer; Alexander E Gorbalenya
Evidence for emergence of diverse polioviruses from C-cluster coxsackie A viruses and implications for global poliovirus eradication.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(22):9457-62.
2007: Kentaro Fujita; Shyam S Krishnakumar; David Franco; Aniko V Paul; Erwin London; Eckard Wimmer
Membrane topography of the hydrophobic anchor sequence of poliovirus 3A and 3AB proteins and the functional effect of 3A/3AB membrane association upon RNA replication.
Biochemistry 2007;46(17):5185-99.
2007: Hidemi Toyoda; Jiang Yin; Steffen Mueller; Eckard Wimmer; Jeronimo Cello
Oncolytic treatment and cure of neuroblastoma by a novel attenuated poliovirus in a novel poliovirus-susceptible animal model.
Cancer research 2007;67(6):2857-64.
2006: Haekyung Lee; Ying Liu; Edison Mejia; Aniko V Paul; Eckard Wimmer
The C-terminal hydrophobic domain of hepatitis C virus RNA polymerase NS5B can be replaced with a heterologous domain of poliovirus protein 3A.
Journal of virology 2006;80(22):11343-54.
2006: Steffen Mueller; Dimitris Papamichail; J. Robert Coleman; Steven Skiena; Eckard Wimmer
Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivity.
Journal of virology 2006;80(19):9687-96.
2006: Eckard Wimmer
The test-tube synthesis of a chemical called poliovirus. The simple synthesis of a virus has far-reaching societal implications.
EMBO reports 2006;7 Spec No():S3-9.
2005: Nidia De Jesus; David Franco; Aniko Paul; Eckard Wimmer; Jeronimo Cello
Mutation of a single conserved nucleotide between the cloverleaf and internal ribosome entry site attenuates poliovirus neurovirulence.
Journal of virology 2005;79(22):14235-43.
2005: Steffen Mueller; Eckard Wimmer; Jeronimo Cello
Poliovirus and poliomyelitis: a tale of guts, brains, and an accidental event.
Virus research 2005;111(2):175-93.
2005: Chuan Xiao; Carol M Bator Kelly; Elizabeth Rieder; Paul R Chipman; Alister Craig; Richard J Kuhn; Eckard Wimmer; Michael G Rossmann
The crystal structure of coxsackievirus A21 and its interaction with ICAM-1.
Structure (London, England : 1993) 2005;13(7):1019-33.
2005: David Franco; Harsh B Pathak; Craig E Cameron; Bart Rombaut; Eckard Wimmer; Aniko V Paul
Stimulation of poliovirus synthesis in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro.
Journal of virology 2005;79(10):6358-67.
2005: Chengyu Liang; Elizabeth Rieder; Bumsuk Hahm; Sung Key Jang; Aniko Paul; Eckard Wimmer
Replication of a novel subgenomic HCV genotype 1a replicon expressing a puromycin resistance gene in Huh-7 cells.
Virology 2005;333(1):41-53.
2005: David Franco; Harsh B Pathak; Craig E Cameron; Bart Rombaut; Eckard Wimmer; Aniko V Paul
Stimulation of poliovirus RNA synthesis and virus maturation in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro.
Virology journal 2005;2():86.
2004: Haekyung Lee; Hyukwoo Shin; Eckard Wimmer; Aniko V Paul
cis-acting RNA signals in the NS5B C-terminal coding sequence of the hepatitis C virus genome.
Journal of virology 2004;78(20):10865-77.
2003: Aniko V Paul; Jiang Yin; JoAnn Mugavero; Elizabeth Rieder; Ying Liu; Eckard Wimmer
A "slide-back" mechanism for the initiation of protein-primed RNA synthesis by the RNA polymerase of poliovirus.
The Journal of biological chemistry 2003;278(45):43951-60.
2003: Steffen Mueller; Thomas A Rosenquist; Yoshimi Takai; Richard A Bronson; Eckard Wimmer
Loss of nectin-2 at Sertoli-spermatid junctions leads to male infertility and correlates with severe spermatozoan head and midpiece malformation, impaired binding to the zona pellucida, and oocyte penetration.
Biology of reproduction 2003;69(4):1330-40.
2003: Steffen Mueller; Eckard Wimmer
Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains.
The Journal of biological chemistry 2003;278(33):31251-60.
2003: Elizabeth Rieder; Wenkai Xiang; Aniko Paul; Eckard Wimmer
Analysis of the cloverleaf element in a human rhinovirus type 14/poliovirus chimera: correlation of subdomain D structure, ternary protein complex formation and virus replication.
The Journal of general virology 2003;84(Pt 8):2203-16.
2003: Jiang Yin; Aniko V Paul; Eckard Wimmer; Elizabeth Rieder
Functional dissection of a poliovirus cis-acting replication element [PV-cre(2C)]: analysis of single- and dual-cre viral genomes and proteins that bind specifically to PV-cre RNA.
Journal of virology 2003;77(9):5152-66.
2003: Yongning He; Steffen Mueller; Paul R Chipman; Carol M Bator; Xiaozhong Peng; valorie bowman; Suchetana Mukhopadhyay; Eckard Wimmer; Richard J Kuhn; Michael G Rossmann
Complexes of poliovirus serotypes with their common cellular receptor, CD155.
Journal of virology 2003;77(8):4827-35.
2003: Aniko V Paul; Julia Peters; JoAnn Mugavero; Jiang Yin; Jacques H van Boom; Eckard Wimmer
Biochemical and genetic studies of the VPg uridylylation reaction catalyzed by the RNA polymerase of poliovirus.
Journal of virology 2003;77(2):891-904.
2002: Jeronimo Cello; Aniko V Paul; Eckard Wimmer
Vaccines should be kept even if polio is wiped out.
Nature 2002;418(6901):915.
2002: Jeronimo Cello; Aniko V Paul; Eckard Wimmer
Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template.
Science (New York, N.Y.) 2002;297(5583):1016-8.
2002: David J Solecki; Matthias Gromeier; Steffen Mueller; Günter Bernhardt; Eckard Wimmer
Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog.
The Journal of biological chemistry 2002;277(28):25697-702.
2002: Y Verlinden; A Cuconati; Eckard Wimmer; B Rombau
The viral protein 3CD induces an equilibrium between the viral protein and RNA synthesis in a cell-free system for poliovirus replication.
Archives of virology 2002;147(4):731-44.
2002: Steffen Mueller; Xuemei Cao; Reinhold Welker; Eckard Wimmer
Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis.
The Journal of biological chemistry 2002;277(10):7897-904.
2002: Thomas Pfister; Huan Feng; Eckard Wimmer; Keith W Jones
Synchrotron radiation-induced X-ray emission to identify metal ions in preparations of purified protein.
BioTechniques 2002;32(1):134-6, 138, 140-1.
2001: K Gerber; Eckard Wimmer; Aniko V Paul
Biochemical and genetic studies of the initiation of human rhinovirus 2 RNA replication: identification of a cis-replicating element in the coding sequence of 2A(pro).
Journal of virology 2001;75(22):10979-90.
2001: K Gerber; Eckard Wimmer; Aniko V Paul
Biochemical and genetic studies of the initiation of human rhinovirus 2 RNA replication: purification and enzymatic analysis of the RNA-dependent RNA polymerase 3D(pol).
Journal of virology 2001;75(22):10969-78.
2001: WD Zhao; Eckard Wimmer
Genetic analysis of a poliovirus/hepatitis C virus chimera: new structure for domain II of the internal ribosomal entry site of hepatitis C virus.
Journal of virology 2001;75(8):3719-30.
2001: Chuan Xiao; Carol M Bator; valorie bowman; Elizabeth Rieder; Yongning He; Benoît Hébert; J Bella; Timothy S Baker; Eckard Wimmer; Richard J Kuhn; Michael G Rossmann
Interaction of coxsackievirus A21 with its cellular receptor, ICAM-1.
Journal of virology 2001;75(5):2444-51.
2001: X Li; H H Lu; Steffen Mueller; Eckard Wimmer
The C-terminal residues of poliovirus proteinase 2A(pro) are critical for viral RNA replication but not for cis- or trans-proteolytic cleavage.
The Journal of general virology 2001;82(Pt 2):397-408.
2001: Thomas Pfister; Eckard Wimmer
Polypeptide p41 of a Norwalk-like virus is a nucleic acid-independent nucleoside triphosphatase.
Journal of virology 2001;75(4):1611-9.
2001: Konstantin Chumakov; Eugenia Dragunsky; Anna V Ivshina; Joan C Enterline; V Wells; Tatsuji Nomura; Matthias Gromeier; Eckard Wimmer
Inactivated vaccines based on alternatives to wild-type seed virus.
Developments in biologicals 2001;105():171-7.
2001: Elizabeth Rieder; Alexander E Gorbalenya; Chuan Xiao; Yongning He; Timothy S Baker; Richard J Kuhn; Michael G Rossmann; Eckard Wimmer
Will the polio niche remain vacant?
Developments in biologicals 2001;105():111-22; discussion 149-50.
2000: Elizabeth Rieder; Aniko V Paul; D W Kim; Jacques H van Boom; Eckard Wimmer
Genetic and biochemical studies of poliovirus cis-acting replication element cre in relation to VPg uridylylation.
Journal of virology 2000;74(22):10371-80.
2000: Aniko V Paul; Elizabeth Rieder; D W Kim; Jacques H van Boom; Eckard Wimmer
Identification of an RNA hairpin in poliovirus RNA that serves as the primary template in the in vitro uridylylation of VPg.
Journal of virology 2000;74(22):10359-70.
2000: Y Verlinden; A Cuconati; Eckard Wimmer; Bart Rombaut
Cell-free synthesis of poliovirus: 14S subunits are the key intermediates in the encapsidation of poliovirus RNA.
The Journal of general virology 2000;81(Pt 11):2751-4.
2000: Y Verlinden; A Cuconati; Eckard Wimmer; Bart Rombaut
The antiviral compound 5-(3,4-dichlorophenyl) methylhydantoin inhibits the post-synthetic cleavages and the assembly of poliovirus in a cell-free system.
Antiviral research 2000;48(1):61-9.
2000: Matthias Gromeier; David J Solecki; Dhavalkumar D Patel; Eckard Wimmer
Expression of the human poliovirus receptor/CD155 gene during development of the central nervous system: implications for the pathogenesis of poliomyelitis.
Virology 2000;273(2):248-57.
2000: WD Zhao; FC Lahser; Eckard Wimmer
Genetic analysis of a poliovirus/hepatitis C virus (HCV) chimera: interaction between the poliovirus cloverleaf and a sequence in the HCV 5' nontranslated region results in a replication phenotype.
Journal of virology 2000;74(13):6223-6.
2000: Aniko V Paul; JoAnn Mugavero; Jiang Yin; S Hobson; S Schultz; Jacques H van Boom; Eckard Wimmer
Studies on the attenuation phenotype of polio vaccines: poliovirus RNA polymerase derived from Sabin type 1 sequence is temperature sensitive in the uridylylation of VPg.
Virology 2000;272(1):72-84.
2000: Matthias Gromeier; S Lachmann; M R Rosenfeld; Philip H Gutin; Eckard Wimmer
Intergeneric poliovirus recombinants for the treatment of malignant glioma.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6803-8.
2000: David J Solecki; Günter Bernhardt; M Lipp; Eckard Wimmer
Identification of a nuclear respiratory factor-1 binding site within the core promoter of the human polio virus receptor/CD155 gene.
The Journal of biological chemistry 2000;275(17):12453-62.
2000: Michael G Rossmann; J Bella; PR Kolatkar; Yongning He; Eckard Wimmer; Richard J Kuhn; Timothy S Baker
Cell recognition and entry by rhino- and enteroviruses.
Virology 2000;269(2):239-47.
2000: Yongning He; valorie bowman; Steffen Mueller; Carol M Bator; J Bella; X Peng; Timothy S Baker; Eckard Wimmer; Richard J Kuhn; Michael G Rossmann
Interaction of the poliovirus receptor with poliovirus.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):79-84.
2000: Thomas Pfister; K W Jones; Eckard Wimmer
A cysteine-rich motif in poliovirus protein 2C(ATPase) is involved in RNA replication and binds zinc in vitro.
Journal of virology 2000;74(1):334-43.
1999: Vadim I Agol; Aniko V Paul; Eckard Wimmer
Paradoxes of the replication of picornaviral genomes.
Virus research 1999;62(2):129-47.
1999: R Duggal; Eckard Wimmer
Genetic recombination of poliovirus in vitro and in vivo: temperature-dependent alteration of crossover sites.
Virology 1999;258(1):30-41.
1999: Thomas Pfister; Eckard Wimmer
Characterization of the nucleoside triphosphatase activity of poliovirus protein 2C reveals a mechanism by which guanidine inhibits poliovirus replication.
The Journal of biological chemistry 1999;274(11):6992-7001.
1999: WD Zhao; Eckard Wimmer; FC Lahser
Poliovirus/Hepatitis C virus (internal ribosomal entry site-core) chimeric viruses: improved growth properties through modification of a proteolytic cleavage site and requirement for core RNA sequences but not for core-related polypeptides.
Journal of virology 1999;73(2):1546-54.
1999: Matthias Gromeier; B Bossert; M Arita; A Nomoto; Eckard Wimmer
Dual stem loops within the poliovirus internal ribosomal entry site control neurovirulence.
Journal of virology 1999;73(2):958-64.
1999: David J Solecki; Eckard Wimmer; M Lipp; Günter Bernhardt
Identification and characterization of the cis-acting elements of the human CD155 gene core promoter.
The Journal of biological chemistry 1999;274(3):1791-800.
1998: Aniko V Paul; JoAnn Mugavero; A Molla; Eckard Wimmer
Internal ribosomal entry site scanning of the poliovirus polyprotein: implications for proteolytic processing.
Virology 1998;250(1):241-53.
1998: Wenkai Xiang; A Cuconati; Debra A Hope; K Kirkegaard; Eckard Wimmer
Complete protein linkage map of poliovirus P3 proteins: interaction of polymerase 3Dpol with VPg and with genetic variants of 3AB.
Journal of virology 1998;72(8):6732-41.
1998: A Cuconati; A Molla; Eckard Wimmer
Brefeldin A inhibits cell-free, de novo synthesis of poliovirus.
Journal of virology 1998;72(8):6456-64.
1998: Matthias Gromeier; Eckard Wimmer
Mechanism of injury-provoked poliomyelitis.
Journal of virology 1998;72(6):5056-60.
1998: Aniko V Paul; Jacques H van Boom; Dmitri V Filippov; Eckard Wimmer
Protein-primed RNA synthesis by purified poliovirus RNA polymerase.
Nature 1998;393(6682):280-4.
1998: A Cuconati; Wenkai Xiang; FC Lahser; Thomas Pfister; Eckard Wimmer
A protein linkage map of the P2 nonstructural proteins of poliovirus.
Journal of virology 1998;72(2):1297-307.
1998: David J Solecki; Matthias Gromeier; J Harber; Günter Bernhardt; Eckard Wimmer
Poliovirus and its cellular receptor: a molecular genetic dissection of a virus/receptor affinity interaction.
Journal of molecular recognition : JMR 1998;11(1-6):2-9.
1998: Steffen Mueller; Eckard Wimmer
Expression of foreign proteins by poliovirus polyprotein fusion: analysis of genetic stability reveals rapid deletions and formation of cardioviruslike open reading frames.
Journal of virology 1998;72(1):20-31.
1997: R Duggal; A Cuconati; Matthias Gromeier; Eckard Wimmer
Genetic recombination of poliovirus in a cell-free system.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13786-91.
1997: Matthias Gromeier; Steffen Mueller; David J Solecki; B Bossert; Günter Bernhardt; Eckard Wimmer
Determinants of poliovirus neurovirulence.
Journal of neurovirology 1997;3 Suppl 1():S35-8.
1997: David J Solecki; S Schwarz; Eckard Wimmer; M Lipp; Günter Bernhardt
The promoters for human and monkey poliovirus receptors. Requirements for basic and cell type-specific activity.
The Journal of biological chemistry 1997;272(9):5579-86.
1996: Matthias Gromeier; L Alexander; Eckard Wimmer
Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2370-5.
1996: H H Lu; Eckard Wimmer
Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1412-7.
1996: X Cao; Eckard Wimmer
Genetic variation of the poliovirus genome with two VPg coding units.
The EMBO journal 1996;15(1):23-33.
1995: J Harber; Günter Bernhardt; H H Lu; J Y Sgro; Eckard Wimmer
Canyon rim residues, including antigenic determinants, modulate serotype-specific binding of polioviruses to mutants of the poliovirus receptor.
Virology 1995;214(2):559-70.
1995: H H Lu; X Li; A Cuconati; Eckard Wimmer
Analysis of picornavirus 2A(pro) proteins: separation of proteinase from translation and replication functions.
Journal of virology 1995;69(12):7445-52.
1995: W Xiang; A Cuconati; Aniko V Paul; X Cao; Eckard Wimmer
Molecular dissection of the multifunctional poliovirus RNA-binding protein 3AB.
RNA (New York, N.Y.) 1995;1(9):892-904.
1995: H H Lu; L Alexander; Eckard Wimmer
Construction and genetic analysis of dicistronic polioviruses containing open reading frames for epitopes of human immunodeficiency virus type 1 gp120.
Journal of virology 1995;69(8):4797-806.
1995: X Cao; Eckard Wimmer
Intragenomic complementation of a 3AB mutant in dicistronic polioviruses.
Virology 1995;209(2):315-26.
1995: W Xiang; Kevin Harris; L Alexander; Eckard Wimmer
Interaction between the 5'-terminal cloverleaf and 3AB/3CDpro of poliovirus is essential for RNA replication.
Journal of virology 1995;69(6):3658-67.
1995: Matthias Gromeier; H H Lu; Günter Bernhardt; J J Harber; J A Bibb; Eckard Wimmer
The human poliovirus receptor. Receptor-virus interaction and parameters of disease specificity.
Annals of the New York Academy of Sciences 1995;753():19-36.
1995: Matthias Gromeier; H H Lu; Eckard Wimmer
Mouse neuropathogenic poliovirus strains cause damage in the central nervous system distinct from poliomyelitis.
Microbial pathogenesis 1995;18(4):253-67.
1994: Aniko V Paul; X Cao; Kevin Harris; J Lama; Eckard Wimmer
Studies with poliovirus polymerase 3Dpol. Stimulation of poly(U) synthesis in vitro by purified poliovirus protein 3AB.
The Journal of biological chemistry 1994;269(46):29173-81.
1994: Tatyana V Pestova; Christopher U T Hellen; Eckard Wimmer
A conserved AUG triplet in the 5' nontranslated region of poliovirus can function as an initiation codon in vitro and in vivo.
Virology 1994;204(2):729-37.
1994: H H Lu; C F Yang; A D Murdin; MH Klein; J J Harber; O M Kew; Eckard Wimmer
Mouse neurovirulence determinants of poliovirus type 1 strain LS-a map to the coding regions of capsid protein VP1 and proteinase 2Apro.
Journal of virology 1994;68(11):7507-15.
1994: A Molla; Kevin Harris; Aniko V Paul; S H Shin; J Mugavero; Eckard Wimmer
Stimulation of poliovirus proteinase 3Cpro-related proteolysis by the genome-linked protein VPg and its precursor 3AB.
The Journal of biological chemistry 1994;269(43):27015-20.
1994: Kevin Harris; W Xiang; L Alexander; William Stratton Lane; Aniko V Paul; Eckard Wimmer
Interaction of poliovirus polypeptide 3CDpro with the 5' and 3' termini of the poliovirus genome. Identification of viral and cellular cofactors needed for efficient binding.
The Journal of biological chemistry 1994;269(43):27004-14.
1994: Christopher U T Hellen; Tatyana V Pestova; Eckard Wimmer
Effect of mutations downstream of the internal ribosome entry site on initiation of poliovirus protein synthesis.
Journal of virology 1994;68(10):6312-22.
1994: J A Bibb; Günter Bernhardt; Eckard Wimmer
The human poliovirus receptor alpha is a serine phosphoprotein.
Journal of virology 1994;68(9):6111-5.
1994: Günter Bernhardt; J Harber; A Zibert; M deCrombrugghe; Eckard Wimmer
The poliovirus receptor: identification of domains and amino acid residues critical for virus binding.
Virology 1994;203(2):344-56.
1994: J A Bibb; Günter Bernhardt; Eckard Wimmer
Cleavage site of the poliovirus receptor signal sequence.
The Journal of general virology 1994;75 ( Pt 8)():1875-81.
1994: J A Bibb; G Witherell; Günter Bernhardt; Eckard Wimmer
Interaction of poliovirus with its cell surface binding site.
Virology 1994;201(1):107-15.
1994: G W Witherell; Eckard Wimmer
Encephalomyocarditis virus internal ribosomal entry site RNA-protein interactions.
Journal of virology 1994;68(5):3183-92.
1994: Aniko V Paul; A Molla; Eckard Wimmer
Studies of a putative amphipathic helix in the N-terminus of poliovirus protein 2C.
Virology 1994;199(1):188-99.
1994: Günter Bernhardt; J A Bibb; Jonathan Bradley; Eckard Wimmer
Molecular characterization of the cellular receptor for poliovirus.
Virology 1994;199(1):105-13.
1994: L Alexander; H H Lu; Eckard Wimmer
Polioviruses containing picornavirus type 1 and/or type 2 internal ribosomal entry site elements: genetic hybrids and the expression of a foreign gene.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(4):1406-10.
1994: Christopher U T Hellen; Tatyana V Pestova; M Litterst; Eckard Wimmer
The cellular polypeptide p57 (pyrimidine tract-binding protein) binds to multiple sites in the poliovirus 5' nontranslated region.
Journal of virology 1994;68(2):941-50.
1994: J Lama; Aniko V Paul; Kevin Harris; Eckard Wimmer
Properties of purified recombinant poliovirus protein 3aB as substrate for viral proteinases and as co-factor for RNA polymerase 3Dpol.
The Journal of biological chemistry 1994;269(1):66-70.
1994: M Schmid; Eckard Wimmer
IRES-controlled protein synthesis and genome replication of poliovirus.
Archives of virology. Supplementum 1994;9():279-89.
1994: L Alexander; H H Lu; Matthias Gromeier; Eckard Wimmer
Dicistronic polioviruses as expression vectors for foreign genes.
AIDS research and human retroviruses 1994;10 Suppl 2():S57-60.
1993: Eckard Wimmer; A Nomoto
Molecular biology and cell-free synthesis of poliovirus.
Biologicals : journal of the International Association of Biological Standardization 1993;21(4):349-56.
1993: A Molla; Aniko V Paul; M Schmid; S K Jang; Eckard Wimmer
Studies on dicistronic polioviruses implicate viral proteinase 2Apro in RNA replication.
Virology 1993;196(2):739-47.
1993: A Molla; Aniko V Paul; Eckard Wimmer
Effects of temperature and lipophilic agents on poliovirus formation and RNA synthesis in a cell-free system.
Journal of virology 1993;67(10):5932-8.
1993: X Cao; R J Kuhn; Eckard Wimmer
Replication of poliovirus RNA containing two VPg coding sequences leads to a specific deletion event.
Journal of virology 1993;67(9):5572-8.
1993: G W Witherell; A Gil; Eckard Wimmer
Interaction of polypyrimidine tract binding protein with the encephalomyocarditis virus mRNA internal ribosomal entry site.
Biochemistry 1993;32(32):8268-75.
1993: Christopher U T Hellen; G W Witherell; M Schmid; S H Shin; Tatyana V Pestova; A Gil; Eckard Wimmer
A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7642-6.
1993: M S Freistadt; H B Fleit; Eckard Wimmer
Poliovirus receptor on human blood cells: a possible extraneural site of poliovirus replication.
Virology 1993;195(2):798-803.
1993: A Molla; Christopher U T Hellen; Eckard Wimmer
Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors.
Journal of virology 1993;67(8):4688-95.
1993: A Molla; Aniko V Paul; Eckard Wimmer
In vitro synthesis of poliovirus.
Developments in biological standardization 1993;78():39-53.
1993: Eckard Wimmer; Christopher U T Hellen; X Cao
Genetics of poliovirus.
Annual review of genetics 1993;27():353-436.
1992: Christopher U T Hellen; Eckard Wimmer
Viral proteases as targets for chemotherapeutic intervention.
Current opinion in biotechnology 1992;3(6):643-9.
1992: Kevin Harris; S R Reddigari; M J Nicklin; T Hämmerle; Eckard Wimmer
Purification and characterization of poliovirus polypeptide 3CD, a proteinase and a precursor for RNA polymerase.
Journal of virology 1992;66(12):7481-9.
1992: A Zibert; Eckard Wimmer
N glycosylation of the virus binding domain is not essential for function of the human poliovirus receptor.
Journal of virology 1992;66(12):7368-73.
1992: T Hämmerle; A Molla; Eckard Wimmer
Mutational analysis of the proposed FG loop of poliovirus proteinase 3C identifies amino acids that are necessary for 3CD cleavage and might be determinants of a function distinct from proteolytic activity.
Journal of virology 1992;66(10):6028-34.
1992: A Zibert; H C Selinka; O Elroy-Stein; Eckard Wimmer
The soluble form of two N-terminal domains of the poliovirus receptor is sufficient for blocking viral infection.
Virus research 1992;25(1-2):51-61.
1992: C Mirzayan; Eckard Wimmer
Genetic analysis of an NTP-binding motif in poliovirus polypeptide 2C.
Virology 1992;189(2):547-55.
1992: Christopher U T Hellen; C K Lee; Eckard Wimmer
Determinants of substrate recognition by poliovirus 2A proteinase.
Journal of virology 1992;66(6):3330-8.
1992: H C Selinka; A Zibert; Eckard Wimmer
A chimeric poliovirus/CD4 receptor confers susceptibility to poliovirus on mouse cells.
Journal of virology 1992;66(4):2523-6.
1992: Christopher U T Hellen; Eckard Wimmer
Maturation of poliovirus capsid proteins.
Virology 1992;187(2):391-7.
1992: A Molla; S K Jang; Aniko V Paul; Q Reuer; Eckard Wimmer
Cardioviral internal ribosomal entry site is functional in a genetically engineered dicistronic poliovirus.
Nature 1992;356(6366):255-7.
1992: A D Murdin; H H Lu; M G Murray; Eckard Wimmer
Poliovirus antigenic hybrids simultaneously expressing antigenic determinants from all three serotypes.
The Journal of general virology 1992;73 ( Pt 3)():607-11.
1991: A Molla; Aniko V Paul; Eckard Wimmer
Cell-free, de novo synthesis of poliovirus.
Science (New York, N.Y.) 1991;254(5038):1647-51.
1991: Tatyana V Pestova; Christopher U T Hellen; Eckard Wimmer
Translation of poliovirus RNA: role of an essential cis-acting oligopyrimidine element within the 5' nontranslated region and involvement of a cellular 57-kilodalton protein.
Journal of virology 1991;65(11):6194-204.
1991: R Altmeyer; A D Murdin; J J Harber; Eckard Wimmer
Construction and characterization of a poliovirus/rhinovirus antigenic hybrid.
Virology 1991;184(2):636-44.
1991: Christopher U T Hellen; M Fäcke; Hans-Georg Kräusslich; C K Lee; Eckard Wimmer
Characterization of poliovirus 2A proteinase by mutational analysis: residues required for autocatalytic activity are essential for induction of cleavage of eukaryotic initiation factor 4F polypeptide p220.
Journal of virology 1991;65(8):4226-31.
1991: K Partin; G Zybarth; L Ehrlich; M DeCrombrugghe; Eckard Wimmer; C Carter
Deletion of sequences upstream of the proteinase improves the proteolytic processing of human immunodeficiency virus type 1.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(11):4776-80.
1991: C Mirzayan; R Ingraham; Eckard Wimmer
Specificity of the polioviral proteinase 3C towards genetically engineered cleavage sites in the viral capsid.
The Journal of general virology 1991;72 ( Pt 5)():1159-63.
1991: A Zibert; H C Selinka; O Elroy-Stein; Bernard Moss; Eckard Wimmer
Vaccinia virus-mediated expression and identification of the human poliovirus receptor.
Virology 1991;182(1):250-9.
1991: H C Selinka; A Zibert; Eckard Wimmer
Poliovirus can enter and infect mammalian cells by way of an intercellular adhesion molecule 1 pathway.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3598-602.
1991: T Hämmerle; Christopher U T Hellen; Eckard Wimmer
Site-directed mutagenesis of the putative catalytic triad of poliovirus 3C proteinase.
The Journal of biological chemistry 1991;266(9):5412-6.
1991: J J Harber; Jonathan Bradley; C W Anderson; Eckard Wimmer
Catalysis of poliovirus VP0 maturation cleavage is not mediated by serine 10 of VP2.
Journal of virology 1991;65(1):326-34.
1991: A D Murdin; C Mirzayan; A Kameda; Eckard Wimmer
The effect of site and mode of expression of a heterologous antigenic determinant on the properties of poliovirus hybrids.
Microbial pathogenesis 1991;10(1):27-37.
1991: K Partin; Eckard Wimmer; C Carter
Mutational analysis of a native substrate of the HIV-1 proteinase.
Advances in experimental medicine and biology 1991;306():503-6.
1991: A D Murdin; A Kameda; M G Murray; Eckard Wimmer
Phenotypic characterization of antigenic hybrids of poliovirus.
Microbial pathogenesis 1991;10(1):39-45.
1990: L S Ehrlich; H G Krausslich; Eckard Wimmer; Carol A Carter
Expression in Escherichia coli and purification of human immunodeficiency virus type 1 capsid protein (p24).
AIDS research and human retroviruses 1990;6(10):1169-75.
1990: S K Jang; Eckard Wimmer
Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein.
Genes & development 1990;4(9):1560-72.
1990: K Partin; Hans-Georg Kräusslich; L Ehrlich; Eckard Wimmer; C Carter
Mutational analysis of a native substrate of the human immunodeficiency virus type 1 proteinase.
Journal of virology 1990;64(8):3938-47.
1990: Q Reuer; R J Kuhn; Eckard Wimmer
Characterization of poliovirus clones containing lethal and nonlethal mutations in the genome-linked protein VPg.
Journal of virology 1990;64(6):2967-75.
1990: Hans-Georg Kräusslich; C Hölscher; Q Reuer; J Harber; Eckard Wimmer
Myristoylation of the poliovirus polyprotein is required for proteolytic processing of the capsid and for viral infectivity.
Journal of virology 1990;64(5):2433-6.
1990: A D Murdin; M G Murray; Eckard Wimmer
Novel approaches to picornavirus vaccines.
Advances in biotechnological processes 1990;14():301-23.
1990: S K Jang; Tatyana V Pestova; Christopher U T Hellen; G W Witherell; Eckard Wimmer
Cap-independent translation of picornavirus RNAs: structure and function of the internal ribosomal entry site.
Enzyme 1990;44(1-4):292-309.
1989: Christopher U T Hellen; Hans-Georg Kräusslich; Eckard Wimmer
Proteolytic processing of polyproteins in the replication of RNA viruses.
Biochemistry 1989;28(26):9881-90.
1989: A D Murdin; Eckard Wimmer
Construction of a poliovirus type 1/type 2 antigenic hybrid by manipulation of neutralization antigenic site II.
Journal of virology 1989;63(12):5251-7.
1989: S K Jang; M V Davies; Randal J Kaufman; Eckard Wimmer
Initiation of protein synthesis by internal entry of ribosomes into the 5' nontranslated region of encephalomyocarditis virus RNA in vivo.
Journal of virology 1989;63(4):1651-60.
1989: Hans-Georg Kräusslich; R H Ingraham; M T Skoog; Eckard Wimmer; P V Pallai; Carol A Carter
Activity of purified biosynthetic proteinase of human immunodeficiency virus on natural substrates and synthetic peptides.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):807-11.
1988: M J Nicklin; Kevin Harris; P V Pallai; Eckard Wimmer
Poliovirus proteinase 3C: large-scale expression, purification, and specific cleavage activity on natural and synthetic substrates in vitro.
Journal of virology 1988;62(12):4586-93.
1988: Hans-Georg Kräusslich; H Schneider; G Zybarth; Carol A Carter; Eckard Wimmer
Processing of in vitro-synthesized gag precursor proteins of human immunodeficiency virus (HIV) type 1 by HIV proteinase generated in Escherichia coli.
Journal of virology 1988;62(11):4393-7.
1988: R J Kuhn; H Tada; M F Ypma-Wong; Bert L Semler; Eckard Wimmer
Mutational analysis of the genome-linked protein VPg of poliovirus.
Journal of virology 1988;62(11):4207-15.
1988: C K Lee; Eckard Wimmer
Proteolytic processing of poliovirus polyprotein: elimination of 2Apro-mediated, alternative cleavage of polypeptide 3CD by in vitro mutagenesis.
Virology 1988;166(2):405-14.
1988: S K Jang; Hans-Georg Kräusslich; M J Nicklin; Gregory M Duke; A C Palmenberg; Eckard Wimmer
A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation.
Journal of virology 1988;62(8):2636-43.
1988: M G Murray; Jonathan Bradley; X F Yang; Eckard Wimmer; Eric G. Moss; Vincent Racaniello
Poliovirus host range is determined by a short amino acid sequence in neutralization antigenic site I.
Science (New York, N.Y.) 1988;241(4862):213-5.
1988: M G Murray; R J Kuhn; M Arita; N Kawamura; A Nomoto; Eckard Wimmer
Poliovirus type 1/type 3 antigenic hybrid virus constructed in vitro elicits type 1 and type 3 neutralizing antibodies in rabbits and monkeys.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(9):3203-7.
1988: Hans-Georg Kräusslich; M J Nicklin; C K Lee; Eckard Wimmer
Polyprotein processing in picornavirus replication.
Biochimie 1988;70(1):119-30.
1988: R J Kuhn; H Tada; M F Ypma-Wong; John J Dunn; Bert L Semler; Eckard Wimmer
Construction of a "mutagenesis cartridge" for poliovirus genome-linked viral protein: isolation and characterization of viable and nonviable mutants.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(2):519-23.
1987: Aniko V Paul; A Schultz; S E Pincus; S Oroszlan; Eckard Wimmer
Capsid protein VP4 of poliovirus is N-myristoylated.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(22):7827-31.
1987: Hans-Georg Kräusslich; M J Nicklin; H Toyoda; D Etchison; Eckard Wimmer
Poliovirus proteinase 2A induces cleavage of eucaryotic initiation factor 4F polypeptide p220.
Journal of virology 1987;61(9):2711-8.
1987: N Takeda; C F Yang; R J Kuhn; Eckard Wimmer
Uridylylation of the genome-linked protein of poliovirus in vitro is dependent upon an endogenous RNA template.
Virus research 1987;8(3):193-204.
1987: M J Nicklin; Hans-Georg Kräusslich; H Toyoda; J J Dunn; Eckard Wimmer
Poliovirus polypeptide precursors: expression in vitro and processing by exogenous 3C and 2A proteinases.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(12):4002-6.
1987: Eddy Arnold; M Luo; G Vriend; M G Rossmann; A C Palmenberg; G D Parks; M J Nicklin; Eckard Wimmer
Implications of the picornavirus capsid structure for polyprotein processing.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(1):21-5.
1987: Eckard Wimmer; R J Kuhn; S Pincus; C F Yang; H Toyoda; M J Nicklin; N Takeda
Molecular events leading to picornavirus genome replication.
Journal of cell science. Supplement 1987;7():251-76.
1987: Aniko V Paul; C F Yang; S K Jang; R J Kuhn; H Tada; M Nicklin; Hans-Georg Kräusslich; C K Lee; Eckard Wimmer
Molecular events leading to poliovirus genome replication.
Cold Spring Harbor symposia on quantitative biology 1987;52():343-52.
1986: H Toyoda; M J Nicklin; M G Murray; C W Anderson; J J Dunn; F W Studier; Eckard Wimmer
A second virus-encoded proteinase involved in proteolytic processing of poliovirus polyprotein.
Cell 1986;45(5):761-70.