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Eckard Wimmer

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
35
Paul, Aniko
15
Mueller, Steffen
14
Gromeier, Matthias
14
Hellen, Christopher
13
Bernhardt, Günter
11
Kräusslich, Hans-Georg
9
Cuconati, A
9
Rieder, Elizabeth
7
Rossmann, Michael
7
Solecki, David
7
Yin, Jiang
6
Pestova, Tatyana
6
Franco, David
6
Cello, Jeronimo
6
Kuhn, Richard

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Publications

TOP 3
Liu Ying; Wimmer Eckard; Paul Aniko V
Cis-acting RNA elements in human and animal plus-strand RNA viruses.
Mueller Steffen; Coleman J Robert; Wimmer Eckard
Putting synthesis into biology: a viral view of genetic engineering through de novo gene and genome synthesis.
Zhang Ping; Mueller Steffen; Morais Marc C; Bator Carol M; Bowman Valorie D; Hafenstein Susan; Wimmer Eckard; Rossmann Michael G
Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses.

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All Publications

2009: Liu Ying; Wimmer Eckard; Paul Aniko V
Cis-acting RNA elements in human and animal plus-strand RNA viruses.
Biochimica et biophysica acta 2009;1789(9-10):495-517.
2009: Mueller Steffen; Coleman J Robert; Wimmer Eckard
Putting synthesis into biology: a viral view of genetic engineering through de novo gene and genome synthesis.
Chemistry & biology 2009;16(3):337-47.
2008: Zhang Ping; Mueller Steffen; Morais Marc C; Bator Carol M; Bowman Valorie D; Hafenstein Susan; Wimmer Eckard; Rossmann Michael G
Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18284-9.
2008: Khan Shaukat; Peng Xiaozhong; Yin Jiang; Zhang Ping; Wimmer Eckard
Characterization of the New World monkey homologues of human poliovirus receptor CD155.
Journal of virology 2008;82(14):7167-79.
2008: Coleman J Robert; Papamichail Dimitris; Skiena Steven; Futcher Bruce; Wimmer Eckard; Mueller Steffen
Virus attenuation by genome-scale changes in codon pair bias.
Science (New York, N.Y.) 2008;320(5884):1784-7.
2008: Cello Jeronimo; Toyoda Hidemi; Dejesus Nidia; Dobrikova Elena Y; Gromeier Matthias; Wimmer Eckard
Growth phenotypes and biosafety profiles in poliovirus-receptor transgenic mice of recombinant oncolytic polio/human rhinoviruses.
Journal of medical virology 2008;80(2):352-9.
2007: Toyoda Hidemi; Franco David; Fujita Kentaro; Paul Aniko V; Wimmer Eckard
Replication of poliovirus requires binding of the poly(rC) binding protein to the cloverleaf as well as to the adjacent C-rich spacer sequence between the cloverleaf and the internal ribosomal entry site.
Journal of virology 2007;81(18):10017-28.
2007: Yin Jiang; Liu Ying; Wimmer Eckard; Paul Aniko V
Complete protein linkage map between the P2 and P3 non-structural proteins of poliovirus.
The Journal of general virology 2007;88(Pt 8):2259-67.
2007: Liu Ying; Franco David; Paul Aniko V; Wimmer Eckard
Tyrosine 3 of poliovirus terminal peptide VPg(3B) has an essential function in RNA replication in the context of its precursor protein, 3AB.
Journal of virology 2007;81(11):5669-84.
2007: Jiang Ping; Faase Johan A J; Toyoda Hidemi; Paul Aniko; Wimmer Eckard; Gorbalenya Alexander E
Evidence for emergence of diverse polioviruses from C-cluster coxsackie A viruses and implications for global poliovirus eradication.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(22):9457-62.
2007: Fujita Kentaro; Krishnakumar Shyam S; Franco David; Paul Aniko V; London Erwin; Wimmer Eckard
Membrane topography of the hydrophobic anchor sequence of poliovirus 3A and 3AB proteins and the functional effect of 3A/3AB membrane association upon RNA replication.
Biochemistry 2007;46(17):5185-99.
2007: Toyoda Hidemi; Yin Jiang; Mueller Steffen; Wimmer Eckard; Cello Jeronimo
Oncolytic treatment and cure of neuroblastoma by a novel attenuated poliovirus in a novel poliovirus-susceptible animal model.
Cancer research 2007;67(6):2857-64.
2006: Lee Haekyung; Liu Ying; Mejia Edison; Paul Aniko V; Wimmer Eckard
The C-terminal hydrophobic domain of hepatitis C virus RNA polymerase NS5B can be replaced with a heterologous domain of poliovirus protein 3A.
Journal of virology 2006;80(22):11343-54.
2006: Mueller Steffen; Papamichail Dimitris; Coleman J Robert; Skiena Steven; Wimmer Eckard
Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivity.
Journal of virology 2006;80(19):9687-96.
2006: Wimmer Eckard
The test-tube synthesis of a chemical called poliovirus. The simple synthesis of a virus has far-reaching societal implications.
EMBO reports 2006;7 Spec No():S3-9.
2005: De Jesus Nidia; Franco David; Paul Aniko; Wimmer Eckard; Cello Jeronimo
Mutation of a single conserved nucleotide between the cloverleaf and internal ribosome entry site attenuates poliovirus neurovirulence.
Journal of virology 2005;79(22):14235-43.
2005: Mueller Steffen; Wimmer Eckard; Cello Jeronimo
Poliovirus and poliomyelitis: a tale of guts, brains, and an accidental event.
Virus research 2005;111(2):175-93.
2005: Xiao Chuan; Bator-Kelly Carol M; Rieder Elizabeth; Chipman Paul R; Craig Alister; Kuhn Richard J; Wimmer Eckard; Rossmann Michael G
The crystal structure of coxsackievirus A21 and its interaction with ICAM-1.
Structure (London, England : 1993) 2005;13(7):1019-33.
2005: Franco David; Pathak Harsh B; Cameron Craig E; Rombaut Bart; Wimmer Eckard; Paul Aniko V
Stimulation of poliovirus synthesis in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro.
Journal of virology 2005;79(10):6358-67.
2005: Liang Chengyu; Rieder Elizabeth; Hahm Bumsuk; Jang Sung Key; Paul Aniko; Wimmer Eckard
Replication of a novel subgenomic HCV genotype 1a replicon expressing a puromycin resistance gene in Huh-7 cells.
Virology 2005;333(1):41-53.
2005: Franco David; Pathak Harsh B; Cameron Craig E; Rombaut Bart; Wimmer Eckard; Paul Aniko V
Stimulation of poliovirus RNA synthesis and virus maturation in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro.
Virology journal 2005;2():86.
2004: Lee Haekyung; Shin Hyukwoo; Wimmer Eckard; Paul Aniko V
cis-acting RNA signals in the NS5B C-terminal coding sequence of the hepatitis C virus genome.
Journal of virology 2004;78(20):10865-77.
2003: Paul Aniko V; Yin Jiang; Mugavero JoAnn; Rieder Elizabeth; Liu Ying; Wimmer Eckard
A "slide-back" mechanism for the initiation of protein-primed RNA synthesis by the RNA polymerase of poliovirus.
The Journal of biological chemistry 2003;278(45):43951-60.
2003: Mueller Steffen; Rosenquist Thomas A; Takai Yoshimi; Bronson Richard A; Wimmer Eckard
Loss of nectin-2 at Sertoli-spermatid junctions leads to male infertility and correlates with severe spermatozoan head and midpiece malformation, impaired binding to the zona pellucida, and oocyte penetration.
Biology of reproduction 2003;69(4):1330-40.
2003: Rieder Elizabeth; Xiang Wenkai; Paul Aniko; Wimmer Eckard
Analysis of the cloverleaf element in a human rhinovirus type 14/poliovirus chimera: correlation of subdomain D structure, ternary protein complex formation and virus replication.
The Journal of general virology 2003;84(Pt 8):2203-16.
2003: Mueller Steffen; Wimmer Eckard
Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains.
The Journal of biological chemistry 2003;278(33):31251-60.
2003: Yin Jiang; Paul Aniko V; Wimmer Eckard; Rieder Elizabeth
Functional dissection of a poliovirus cis-acting replication element [PV-cre(2C)]: analysis of single- and dual-cre viral genomes and proteins that bind specifically to PV-cre RNA.
Journal of virology 2003;77(9):5152-66.
2003: He Yongning; Mueller Steffen; Chipman Paul R; Bator Carol M; Peng Xiaozhong; Bowman Valorie D; Mukhopadhyay Suchetana; Wimmer Eckard; Kuhn Richard J; Rossmann Michael G
Complexes of poliovirus serotypes with their common cellular receptor, CD155.
Journal of virology 2003;77(8):4827-35.
2003: Paul Aniko V; Peters Julia; Mugavero JoAnn; Yin Jiang; van Boom Jacques H; Wimmer E
Biochemical and genetic studies of the VPg uridylylation reaction catalyzed by the RNA polymerase of poliovirus.
Journal of virology 2003;77(2):891-904.
2002: Cello Jeronimo; Paul Aniko V; Wimmer Eckard
Vaccines should be kept even if polio is wiped out.
Nature 2002;418(6901):915.
2002: Cello Jeronimo; Paul Aniko V; Wimmer Eckard
Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template.
Science (New York, N.Y.) 2002;297(5583):1016-8.
2002: Solecki David J; Gromeier Matthias; Mueller Steffen; Bernhardt Günter; Wimmer Eckard
Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog.
The Journal of biological chemistry 2002;277(28):25697-702.
2002: Verlinden Y; Cuconati A; Wimmer E; Rombau B
The viral protein 3CD induces an equilibrium between the viral protein and RNA synthesis in a cell-free system for poliovirus replication.
Archives of virology 2002;147(4):731-44.
2002: Mueller Steffen; Cao Xuemei; Welker Reinhold; Wimmer Eckard
Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis.
The Journal of biological chemistry 2002;277(10):7897-904.
2002: Pfister Thomas; Feng Huan; Wimmer Eckard; Jones Keith W
Synchrotron radiation-induced X-ray emission to identify metal ions in preparations of purified protein.
BioTechniques 2002;32(1):134-6, 138, 140-1.
2001: Gerber K; Wimmer E; Paul A V
Biochemical and genetic studies of the initiation of human rhinovirus 2 RNA replication: identification of a cis-replicating element in the coding sequence of 2A(pro).
Journal of virology 2001;75(22):10979-90.
2001: Gerber K; Wimmer E; Paul A V
Biochemical and genetic studies of the initiation of human rhinovirus 2 RNA replication: purification and enzymatic analysis of the RNA-dependent RNA polymerase 3D(pol).
Journal of virology 2001;75(22):10969-78.
2001: Zhao W D; Wimmer E
Genetic analysis of a poliovirus/hepatitis C virus chimera: new structure for domain II of the internal ribosomal entry site of hepatitis C virus.
Journal of virology 2001;75(8):3719-30.
2001: Xiao C; Bator C M; Bowman V D; Rieder E; He Y; Hébert B; Bella J; Baker T S; Wimmer E; Kuhn R J; Rossmann M G
Interaction of coxsackievirus A21 with its cellular receptor, ICAM-1.
Journal of virology 2001;75(5):2444-51.
2001: Li X; Lu H H; Mueller S; Wimmer E
The C-terminal residues of poliovirus proteinase 2A(pro) are critical for viral RNA replication but not for cis- or trans-proteolytic cleavage.
The Journal of general virology 2001;82(Pt 2):397-408.
2001: Pfister T; Wimmer E
Polypeptide p41 of a Norwalk-like virus is a nucleic acid-independent nucleoside triphosphatase.
Journal of virology 2001;75(4):1611-9.
2001: Chumakov K; Dragunsky E; Ivshina A; Enterline J; Wells V; Nomura T; Gromeier M; Wimmer E
Inactivated vaccines based on alternatives to wild-type seed virus.
Developments in biologicals 2001;105():171-7.
2001: Rieder E; Gorbalenya A E; Xiao C; He Y; Baker T S; Kuhn R J; Rossmann M G; Wimmer E
Will the polio niche remain vacant?
Developments in biologicals 2001;105():111-22; discussion 149-50.
2000: Rieder E; Paul A V; Kim D W; van Boom J H; Wimmer E
Genetic and biochemical studies of poliovirus cis-acting replication element cre in relation to VPg uridylylation.
Journal of virology 2000;74(22):10371-80.
2000: Paul A V; Rieder E; Kim D W; van Boom J H; Wimmer E
Identification of an RNA hairpin in poliovirus RNA that serves as the primary template in the in vitro uridylylation of VPg.
Journal of virology 2000;74(22):10359-70.
2000: Verlinden Y; Cuconati A; Wimmer E; Rombaut B
Cell-free synthesis of poliovirus: 14S subunits are the key intermediates in the encapsidation of poliovirus RNA.
The Journal of general virology 2000;81(Pt 11):2751-4.
2000: Verlinden Y; Cuconati A; Wimmer E; Rombaut B
The antiviral compound 5-(3,4-dichlorophenyl) methylhydantoin inhibits the post-synthetic cleavages and the assembly of poliovirus in a cell-free system.
Antiviral research 2000;48(1):61-9.
2000: Gromeier M; Solecki D; Patel D D; Wimmer E
Expression of the human poliovirus receptor/CD155 gene during development of the central nervous system: implications for the pathogenesis of poliomyelitis.
Virology 2000;273(2):248-57.
2000: Zhao W D; Lahser F C; Wimmer E
Genetic analysis of a poliovirus/hepatitis C virus (HCV) chimera: interaction between the poliovirus cloverleaf and a sequence in the HCV 5' nontranslated region results in a replication phenotype.
Journal of virology 2000;74(13):6223-6.
2000: Paul A V; Mugavero J; Yin J; Hobson S; Schultz S; van Boom J H; Wimmer E
Studies on the attenuation phenotype of polio vaccines: poliovirus RNA polymerase derived from Sabin type 1 sequence is temperature sensitive in the uridylylation of VPg.
Virology 2000;272(1):72-84.
2000: Gromeier M; Lachmann S; Rosenfeld M R; Gutin P H; Wimmer E
Intergeneric poliovirus recombinants for the treatment of malignant glioma.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6803-8.
2000: Solecki D; Bernhardt G; Lipp M; Wimmer E
Identification of a nuclear respiratory factor-1 binding site within the core promoter of the human polio virus receptor/CD155 gene.
The Journal of biological chemistry 2000;275(17):12453-62.
2000: Rossmann M G; Bella J; Kolatkar P R; He Y; Wimmer E; Kuhn R J; Baker T S
Cell recognition and entry by rhino- and enteroviruses.
Virology 2000;269(2):239-47.
2000: He Y; Bowman V D; Mueller S; Bator C M; Bella J; Peng X; Baker T S; Wimmer E; Kuhn R J; Rossmann M G
Interaction of the poliovirus receptor with poliovirus.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(1):79-84.
2000: Pfister T; Jones K W; Wimmer E
A cysteine-rich motif in poliovirus protein 2C(ATPase) is involved in RNA replication and binds zinc in vitro.
Journal of virology 2000;74(1):334-43.
1999: Agol V I; Paul A V; Wimmer E
Paradoxes of the replication of picornaviral genomes.
Virus research 1999;62(2):129-47.
1999: Duggal R; Wimmer E
Genetic recombination of poliovirus in vitro and in vivo: temperature-dependent alteration of crossover sites.
Virology 1999;258(1):30-41.
1999: Pfister T; Wimmer E
Characterization of the nucleoside triphosphatase activity of poliovirus protein 2C reveals a mechanism by which guanidine inhibits poliovirus replication.
The Journal of biological chemistry 1999;274(11):6992-7001.
1999: Zhao W D; Wimmer E; Lahser F C
Poliovirus/Hepatitis C virus (internal ribosomal entry site-core) chimeric viruses: improved growth properties through modification of a proteolytic cleavage site and requirement for core RNA sequences but not for core-related polypeptides.
Journal of virology 1999;73(2):1546-54.
1999: Gromeier M; Bossert B; Arita M; Nomoto A; Wimmer E
Dual stem loops within the poliovirus internal ribosomal entry site control neurovirulence.
Journal of virology 1999;73(2):958-64.
1999: Solecki D; Wimmer E; Lipp M; Bernhardt G
Identification and characterization of the cis-acting elements of the human CD155 gene core promoter.
The Journal of biological chemistry 1999;274(3):1791-800.
1998: Paul A V; Mugavero J; Molla A; Wimmer E
Internal ribosomal entry site scanning of the poliovirus polyprotein: implications for proteolytic processing.
Virology 1998;250(1):241-53.
1998: Xiang W; Cuconati A; Hope D; Kirkegaard K; Wimmer E
Complete protein linkage map of poliovirus P3 proteins: interaction of polymerase 3Dpol with VPg and with genetic variants of 3AB.
Journal of virology 1998;72(8):6732-41.
1998: Cuconati A; Molla A; Wimmer E
Brefeldin A inhibits cell-free, de novo synthesis of poliovirus.
Journal of virology 1998;72(8):6456-64.
1998: Gromeier M; Wimmer E
Mechanism of injury-provoked poliomyelitis.
Journal of virology 1998;72(6):5056-60.
1998: Paul A V; van Boom J H; Filippov D; Wimmer E
Protein-primed RNA synthesis by purified poliovirus RNA polymerase.
Nature 1998;393(6682):280-4.
1998: Cuconati A; Xiang W; Lahser F; Pfister T; Wimmer E
A protein linkage map of the P2 nonstructural proteins of poliovirus.
Journal of virology 1998;72(2):1297-307.
1998: Mueller S; Wimmer E
Expression of foreign proteins by poliovirus polyprotein fusion: analysis of genetic stability reveals rapid deletions and formation of cardioviruslike open reading frames.
Journal of virology 1998;72(1):20-31.
1998: Solecki D; Gromeier M; Harber J; Bernhardt G; Wimmer E
Poliovirus and its cellular receptor: a molecular genetic dissection of a virus/receptor affinity interaction.
Journal of molecular recognition : JMR 1998;11(1-6):2-9.
1997: Duggal R; Cuconati A; Gromeier M; Wimmer E
Genetic recombination of poliovirus in a cell-free system.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13786-91.
1997: Gromeier M; Mueller S; Solecki D; Bossert B; Bernhardt G; Wimmer E
Determinants of poliovirus neurovirulence.
Journal of neurovirology 1997;3 Suppl 1():S35-8.
1997: Solecki D; Schwarz S; Wimmer E; Lipp M; Bernhardt G
The promoters for human and monkey poliovirus receptors. Requirements for basic and cell type-specific activity.
The Journal of biological chemistry 1997;272(9):5579-86.
1996: Gromeier M; Alexander L; Wimmer E
Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2370-5.
1996: Lu H H; Wimmer E
Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1412-7.
1996: Cao X; Wimmer E
Genetic variation of the poliovirus genome with two VPg coding units.
The EMBO journal 1996;15(1):23-33.
1995: Harber J; Bernhardt G; Lu H H; Sgro J Y; Wimmer E
Canyon rim residues, including antigenic determinants, modulate serotype-specific binding of polioviruses to mutants of the poliovirus receptor.
Virology 1995;214(2):559-70.
1995: Lu H H; Li X; Cuconati A; Wimmer E
Analysis of picornavirus 2A(pro) proteins: separation of proteinase from translation and replication functions.
Journal of virology 1995;69(12):7445-52.
1995: Xiang W; Cuconati A; Paul A V; Cao X; Wimmer E
Molecular dissection of the multifunctional poliovirus RNA-binding protein 3AB.
RNA (New York, N.Y.) 1995;1(9):892-904.
1995: Lu H H; Alexander L; Wimmer E
Construction and genetic analysis of dicistronic polioviruses containing open reading frames for epitopes of human immunodeficiency virus type 1 gp120.
Journal of virology 1995;69(8):4797-806.
1995: Cao X; Wimmer E
Intragenomic complementation of a 3AB mutant in dicistronic polioviruses.
Virology 1995;209(2):315-26.
1995: Xiang W; Harris K S; Alexander L; Wimmer E
Interaction between the 5'-terminal cloverleaf and 3AB/3CDpro of poliovirus is essential for RNA replication.
Journal of virology 1995;69(6):3658-67.
1995: Gromeier M; Lu H H; Bernhardt G; Harber J J; Bibb J A; Wimmer E
The human poliovirus receptor. Receptor-virus interaction and parameters of disease specificity.
Annals of the New York Academy of Sciences 1995;753():19-36.
1995: Gromeier M; Lu H H; Wimmer E
Mouse neuropathogenic poliovirus strains cause damage in the central nervous system distinct from poliomyelitis.
Microbial pathogenesis 1995;18(4):253-67.
1994: Paul A V; Cao X; Harris K S; Lama J; Wimmer E
Studies with poliovirus polymerase 3Dpol. Stimulation of poly(U) synthesis in vitro by purified poliovirus protein 3AB.
The Journal of biological chemistry 1994;269(46):29173-81.
1994: Pestova T V; Hellen C U; Wimmer E
A conserved AUG triplet in the 5' nontranslated region of poliovirus can function as an initiation codon in vitro and in vivo.
Virology 1994;204(2):729-37.
1994: Lu H H; Yang C F; Murdin A D; Klein M H; Harber J J; Kew O M; Wimmer E
Mouse neurovirulence determinants of poliovirus type 1 strain LS-a map to the coding regions of capsid protein VP1 and proteinase 2Apro.
Journal of virology 1994;68(11):7507-15.
1994: Hellen C U; Pestova T V; Wimmer E
Effect of mutations downstream of the internal ribosome entry site on initiation of poliovirus protein synthesis.
Journal of virology 1994;68(10):6312-22.
1994: Molla A; Harris K S; Paul A V; Shin S H; Mugavero J; Wimmer E
Stimulation of poliovirus proteinase 3Cpro-related proteolysis by the genome-linked protein VPg and its precursor 3AB.
The Journal of biological chemistry 1994;269(43):27015-20.
1994: Harris K S; Xiang W; Alexander L; Lane W S; Paul A V; Wimmer E
Interaction of poliovirus polypeptide 3CDpro with the 5' and 3' termini of the poliovirus genome. Identification of viral and cellular cofactors needed for efficient binding.
The Journal of biological chemistry 1994;269(43):27004-14.
1994: Bibb J A; Bernhardt G; Wimmer E
The human poliovirus receptor alpha is a serine phosphoprotein.
Journal of virology 1994;68(9):6111-5.
1994: Bernhardt G; Harber J; Zibert A; deCrombrugghe M; Wimmer E
The poliovirus receptor: identification of domains and amino acid residues critical for virus binding.
Virology 1994;203(2):344-56.
1994: Bibb J A; Bernhardt G; Wimmer E
Cleavage site of the poliovirus receptor signal sequence.
The Journal of general virology 1994;75 ( Pt 8)():1875-81.
1994: Bibb J A; Witherell G; Bernhardt G; Wimmer E
Interaction of poliovirus with its cell surface binding site.
Virology 1994;201(1):107-15.
1994: Witherell G W; Wimmer E
Encephalomyocarditis virus internal ribosomal entry site RNA-protein interactions.
Journal of virology 1994;68(5):3183-92.
1994: Hellen C U; Pestova T V; Litterst M; Wimmer E
The cellular polypeptide p57 (pyrimidine tract-binding protein) binds to multiple sites in the poliovirus 5' nontranslated region.
Journal of virology 1994;68(2):941-50.
1994: Paul A V; Molla A; Wimmer E
Studies of a putative amphipathic helix in the N-terminus of poliovirus protein 2C.
Virology 1994;199(1):188-99.
1994: Bernhardt G; Bibb J A; Bradley J; Wimmer E
Molecular characterization of the cellular receptor for poliovirus.
Virology 1994;199(1):105-13.
1994: Alexander L; Lu H H; Wimmer E
Polioviruses containing picornavirus type 1 and/or type 2 internal ribosomal entry site elements: genetic hybrids and the expression of a foreign gene.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(4):1406-10.
1994: Lama J; Paul A V; Harris K S; Wimmer E
Properties of purified recombinant poliovirus protein 3aB as substrate for viral proteinases and as co-factor for RNA polymerase 3Dpol.
The Journal of biological chemistry 1994;269(1):66-70.
1994: Schmid M; Wimmer E
IRES-controlled protein synthesis and genome replication of poliovirus.
Archives of virology. Supplementum 1994;9():279-89.
1994: Alexander L; Lu H H; Gromeier M; Wimmer E
Dicistronic polioviruses as expression vectors for foreign genes.
AIDS research and human retroviruses 1994;10 Suppl 2():S57-60.
1993: Wimmer E; Nomoto A
Molecular biology and cell-free synthesis of poliovirus.
Biologicals : journal of the International Association of Biological Standardization 1993;21(4):349-56.
1993: Molla A; Paul A V; Schmid M; Jang S K; Wimmer E
Studies on dicistronic polioviruses implicate viral proteinase 2Apro in RNA replication.
Virology 1993;196(2):739-47.
1993: Molla A; Paul A V; Wimmer E
Effects of temperature and lipophilic agents on poliovirus formation and RNA synthesis in a cell-free system.
Journal of virology 1993;67(10):5932-8.
1993: Cao X; Kuhn R J; Wimmer E
Replication of poliovirus RNA containing two VPg coding sequences leads to a specific deletion event.
Journal of virology 1993;67(9):5572-8.
1993: Hellen C U; Witherell G W; Schmid M; Shin S H; Pestova T V; Gil A; Wimmer E
A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7642-6.
1993: Witherell G W; Gil A; Wimmer E
Interaction of polypyrimidine tract binding protein with the encephalomyocarditis virus mRNA internal ribosomal entry site.
Biochemistry 1993;32(32):8268-75.
1993: Freistadt M S; Fleit H B; Wimmer E
Poliovirus receptor on human blood cells: a possible extraneural site of poliovirus replication.
Virology 1993;195(2):798-803.
1993: Molla A; Hellen C U; Wimmer E
Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors.
Journal of virology 1993;67(8):4688-95.
1993: Molla A; Paul A V; Wimmer E
In vitro synthesis of poliovirus.
Developments in biological standardization 1993;78():39-53.
1993: Wimmer E; Hellen C U; Cao X
Genetics of poliovirus.
Annual review of genetics 1993;27():353-436.
1992: Hellen C U; Wimmer E
Viral proteases as targets for chemotherapeutic intervention.
Current opinion in biotechnology 1992;3(6):643-9.
1992: Harris K S; Reddigari S R; Nicklin M J; Hämmerle T; Wimmer E
Purification and characterization of poliovirus polypeptide 3CD, a proteinase and a precursor for RNA polymerase.
Journal of virology 1992;66(12):7481-9.
1992: Zibert A; Wimmer E
N glycosylation of the virus binding domain is not essential for function of the human poliovirus receptor.
Journal of virology 1992;66(12):7368-73.
1992: Hämmerle T; Molla A; Wimmer E
Mutational analysis of the proposed FG loop of poliovirus proteinase 3C identifies amino acids that are necessary for 3CD cleavage and might be determinants of a function distinct from proteolytic activity.
Journal of virology 1992;66(10):6028-34.
1992: Zibert A; Selinka H C; Elroy-Stein O; Wimmer E
The soluble form of two N-terminal domains of the poliovirus receptor is sufficient for blocking viral infection.
Virus research 1992;25(1-2):51-61.
1992: Mirzayan C; Wimmer E
Genetic analysis of an NTP-binding motif in poliovirus polypeptide 2C.
Virology 1992;189(2):547-55.
1992: Hellen C U; Lee C K; Wimmer E
Determinants of substrate recognition by poliovirus 2A proteinase.
Journal of virology 1992;66(6):3330-8.
1992: Selinka H C; Zibert A; Wimmer E
A chimeric poliovirus/CD4 receptor confers susceptibility to poliovirus on mouse cells.
Journal of virology 1992;66(4):2523-6.
1992: Hellen C U; Wimmer E
Maturation of poliovirus capsid proteins.
Virology 1992;187(2):391-7.
1992: Murdin A D; Lu H H; Murray M G; Wimmer E
Poliovirus antigenic hybrids simultaneously expressing antigenic determinants from all three serotypes.
The Journal of general virology 1992;73 ( Pt 3)():607-11.
1992: Molla A; Jang S K; Paul A V; Reuer Q; Wimmer E
Cardioviral internal ribosomal entry site is functional in a genetically engineered dicistronic poliovirus.
Nature 1992;356(6366):255-7.
1991: Molla A; Paul A V; Wimmer E
Cell-free, de novo synthesis of poliovirus.
Science (New York, N.Y.) 1991;254(5038):1647-51.
1991: Pestova T V; Hellen C U; Wimmer E
Translation of poliovirus RNA: role of an essential cis-acting oligopyrimidine element within the 5' nontranslated region and involvement of a cellular 57-kilodalton protein.
Journal of virology 1991;65(11):6194-204.
1991: Altmeyer R; Murdin A D; Harber J J; Wimmer E
Construction and characterization of a poliovirus/rhinovirus antigenic hybrid.
Virology 1991;184(2):636-44.
1991: Hellen C U; Fäcke M; Kräusslich H G; Lee C K; Wimmer E
Characterization of poliovirus 2A proteinase by mutational analysis: residues required for autocatalytic activity are essential for induction of cleavage of eukaryotic initiation factor 4F polypeptide p220.
Journal of virology 1991;65(8):4226-31.
1991: Partin K; Zybarth G; Ehrlich L; DeCrombrugghe M; Wimmer E; Carter C
Deletion of sequences upstream of the proteinase improves the proteolytic processing of human immunodeficiency virus type 1.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(11):4776-80.
1991: Mirzayan C; Ingraham R; Wimmer E
Specificity of the polioviral proteinase 3C towards genetically engineered cleavage sites in the viral capsid.
The Journal of general virology 1991;72 ( Pt 5)():1159-63.
1991: Zibert A; Selinka H C; Elroy-Stein O; Moss B; Wimmer E
Vaccinia virus-mediated expression and identification of the human poliovirus receptor.
Virology 1991;182(1):250-9.
1991: Selinka H C; Zibert A; Wimmer E
Poliovirus can enter and infect mammalian cells by way of an intercellular adhesion molecule 1 pathway.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3598-602.
1991: Hämmerle T; Hellen C U; Wimmer E
Site-directed mutagenesis of the putative catalytic triad of poliovirus 3C proteinase.
The Journal of biological chemistry 1991;266(9):5412-6.
1991: Harber J J; Bradley J; Anderson C W; Wimmer E
Catalysis of poliovirus VP0 maturation cleavage is not mediated by serine 10 of VP2.
Journal of virology 1991;65(1):326-34.
1991: Murdin A D; Mirzayan C; Kameda A; Wimmer E
The effect of site and mode of expression of a heterologous antigenic determinant on the properties of poliovirus hybrids.
Microbial pathogenesis 1991;10(1):27-37.
1991: Murdin A D; Kameda A; Murray M G; Wimmer E
Phenotypic characterization of antigenic hybrids of poliovirus.
Microbial pathogenesis 1991;10(1):39-45.
1991: Partin K; Wimmer E; Carter C
Mutational analysis of a native substrate of the HIV-1 proteinase.
Advances in experimental medicine and biology 1991;306():503-6.
1990: Ehrlich L S; Krausslich H G; Wimmer E; Carter C A
Expression in Escherichia coli and purification of human immunodeficiency virus type 1 capsid protein (p24).
AIDS research and human retroviruses 1990;6(10):1169-75.
1990: Jang S K; Wimmer E
Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein.
Genes & development 1990;4(9):1560-72.
1990: Partin K; Kräusslich H G; Ehrlich L; Wimmer E; Carter C
Mutational analysis of a native substrate of the human immunodeficiency virus type 1 proteinase.
Journal of virology 1990;64(8):3938-47.
1990: Reuer Q; Kuhn R J; Wimmer E
Characterization of poliovirus clones containing lethal and nonlethal mutations in the genome-linked protein VPg.
Journal of virology 1990;64(6):2967-75.
1990: Kräusslich H G; Hölscher C; Reuer Q; Harber J; Wimmer E
Myristoylation of the poliovirus polyprotein is required for proteolytic processing of the capsid and for viral infectivity.
Journal of virology 1990;64(5):2433-6.
1990: Murdin A D; Murray M G; Wimmer E
Novel approaches to picornavirus vaccines.
Advances in biotechnological processes 1990;14():301-23.
1990: Jang S K; Pestova T V; Hellen C U; Witherell G W; Wimmer E
Cap-independent translation of picornavirus RNAs: structure and function of the internal ribosomal entry site.
Enzyme 1990;44(1-4):292-309.
1989: Hellen C U; Kräusslich H G; Wimmer E
Proteolytic processing of polyproteins in the replication of RNA viruses.
Biochemistry 1989;28(26):9881-90.
1989: Murdin A D; Wimmer E
Construction of a poliovirus type 1/type 2 antigenic hybrid by manipulation of neutralization antigenic site II.
Journal of virology 1989;63(12):5251-7.
1989: Jang S K; Davies M V; Kaufman R J; Wimmer E
Initiation of protein synthesis by internal entry of ribosomes into the 5' nontranslated region of encephalomyocarditis virus RNA in vivo.
Journal of virology 1989;63(4):1651-60.
1989: Kräusslich H G; Ingraham R H; Skoog M T; Wimmer E; Pallai P V; Carter C A
Activity of purified biosynthetic proteinase of human immunodeficiency virus on natural substrates and synthetic peptides.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):807-11.
1988: Nicklin M J; Harris K S; Pallai P V; Wimmer E
Poliovirus proteinase 3C: large-scale expression, purification, and specific cleavage activity on natural and synthetic substrates in vitro.
Journal of virology 1988;62(12):4586-93.
1988: Kräusslich H G; Schneider H; Zybarth G; Carter C A; Wimmer E
Processing of in vitro-synthesized gag precursor proteins of human immunodeficiency virus (HIV) type 1 by HIV proteinase generated in Escherichia coli.
Journal of virology 1988;62(11):4393-7.
1988: Kuhn R J; Tada H; Ypma-Wong M F; Semler B L; Wimmer E
Mutational analysis of the genome-linked protein VPg of poliovirus.
Journal of virology 1988;62(11):4207-15.
1988: Lee C K; Wimmer E
Proteolytic processing of poliovirus polyprotein: elimination of 2Apro-mediated, alternative cleavage of polypeptide 3CD by in vitro mutagenesis.
Virology 1988;166(2):405-14.
1988: Jang S K; Kräusslich H G; Nicklin M J; Duke G M; Palmenberg A C; Wimmer E
A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation.
Journal of virology 1988;62(8):2636-43.
1988: Murray M G; Bradley J; Yang X F; Wimmer E; Moss E G; Racaniello V R
Poliovirus host range is determined by a short amino acid sequence in neutralization antigenic site I.
Science (New York, N.Y.) 1988;241(4862):213-5.
1988: Murray M G; Kuhn R J; Arita M; Kawamura N; Nomoto A; Wimmer E
Poliovirus type 1/type 3 antigenic hybrid virus constructed in vitro elicits type 1 and type 3 neutralizing antibodies in rabbits and monkeys.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(9):3203-7.
1988: Kräusslich H G; Nicklin M J; Lee C K; Wimmer E
Polyprotein processing in picornavirus replication.
Biochimie 1988;70(1):119-30.
1988: Kuhn R J; Tada H; Ypma-Wong M F; Dunn J J; Semler B L; Wimmer E
Construction of a "mutagenesis cartridge" for poliovirus genome-linked viral protein: isolation and characterization of viable and nonviable mutants.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(2):519-23.
1987: Paul A V; Schultz A; Pincus S E; Oroszlan S; Wimmer E
Capsid protein VP4 of poliovirus is N-myristoylated.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(22):7827-31.
1987: Kräusslich H G; Nicklin M J; Toyoda H; Etchison D; Wimmer E
Poliovirus proteinase 2A induces cleavage of eucaryotic initiation factor 4F polypeptide p220.
Journal of virology 1987;61(9):2711-8.
1987: Takeda N; Yang C F; Kuhn R J; Wimmer E
Uridylylation of the genome-linked protein of poliovirus in vitro is dependent upon an endogenous RNA template.
Virus research 1987;8(3):193-204.
1987: Nicklin M J; Kräusslich H G; Toyoda H; Dunn J J; Wimmer E
Poliovirus polypeptide precursors: expression in vitro and processing by exogenous 3C and 2A proteinases.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(12):4002-6.
1987: Arnold E; Luo M; Vriend G; Rossmann M G; Palmenberg A C; Parks G D; Nicklin M J; Wimmer E
Implications of the picornavirus capsid structure for polyprotein processing.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(1):21-5.
1987: Wimmer E; Kuhn R J; Pincus S; Yang C F; Toyoda H; Nicklin M J; Takeda N
Molecular events leading to picornavirus genome replication.
Journal of cell science. Supplement 1987;7():251-76.
1987: Paul A V; Yang C F; Jang S K; Kuhn R J; Tada H; Nicklin M; Kräusslich H G; Lee C K; Wimmer E
Molecular events leading to poliovirus genome replication.
Cold Spring Harbor symposia on quantitative biology 1987;52():343-52.
1986: Toyoda H; Nicklin M J; Murray M G; Anderson C W; Dunn J J; Studier F W; Wimmer E
A second virus-encoded proteinase involved in proteolytic processing of poliovirus polyprotein.
Cell 1986;45(5):761-70.

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