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Otto Windl

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Germany

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Oligonucleotide Array Sequence Analysis

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Mick J Stack; Otto Windl; M J Chaplin; L A Davis; S Everitt; J Hope; Marion M Simmons; P Burke
Four BSE cases with an L-BSE molecular profile in cattle from Great Britain.
Otto Windl; Mike Dawson
Animal prion diseases.
Leigh Thorne; Otto Windl; Jane Edwards; Kevin C Gough; Thomas Holder; Ben C Maddison; Andrew Ramsay; Maged Mohamed Taema; Linda Ann Terry
In vitro amplification of ovine prions from scrapie-infected sheep from Great Britain reveals distinct patterns of propagation.

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2013: Mick J Stack; Otto Windl; M J Chaplin; L A Davis; S Everitt; J Hope; Marion M Simmons; P Burke
Four BSE cases with an L-BSE molecular profile in cattle from Great Britain.
The Veterinary record 2013;172(3):70.
2012: Otto Windl; Mike Dawson
Animal prion diseases.
Sub-cellular biochemistry 2012;65():497-516.
2012: Leigh Thorne; Otto Windl; Jane Edwards; Kevin C Gough; Thomas Holder; Ben C Maddison; Andrew Ramsay; Maged Mohamed Taema; Linda Ann Terry
In vitro amplification of ovine prions from scrapie-infected sheep from Great Britain reveals distinct patterns of propagation.
BMC veterinary research 2012;8():223.
2011: Penelope Papasavva-Stylianou; Otto Windl; Ginny Saunders; Petroula Mavrikiou; Pavlos Toumazos; Charalambos Kakoyiannis
PrP gene polymorphisms in Cyprus goats and their association with resistance or susceptibility to natural scrapie.
Veterinary journal (London, England : 1997) 2011;187(2):245-50.
2011: Wilfred Goldmann; Lorenzo González; David Parnham; Kelly Ryan; Ginny Saunders; Paula Stewart; Otto Windl; Rosa Xicohtencatl; Alex Bossers; Nora Fernandez; James Foster
Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom.
Veterinary research 2011;42(1):110.
2010: Monique Provansal; Stephane Roche; Manuela Pastore; Danielle Casanova; Maxime Belondrade; Sandrine Alais; Pascal Leblanc; Otto Windl; Sylvain Lehmann
Proteomic consequences of expression and pathological conversion of the prion protein in inducible neuroblastoma N2a cells.
Prion 2010;4(4):292-301.
2010: Michael H Neale; Susan J Mountjoy; Jane C Edwards; Didier Vilette; Hubert Laude; Otto Windl; Ginny C Saunders
Infection of cell lines with experimental and natural ovine scrapie agents.
Journal of virology 2010;84(5):2444-52.
2010: Yue Tang; Wei Xiang; Linda Terry; Hans A Kretzschmar; Otto Windl
Transcriptional analysis implicates endoplasmic reticulum stress in bovine spongiform encephalopathy.
PloS one 2010;5(12):e14207.
2009: Lorenzo González; Stuart Martin; Sílvia Sisó; Timm Konold; Angel Ortiz-Peláez; Laura Phelan; Wilfred Goldmann; Paula Stewart; Ginny Saunders; Otto Windl; Martin Jeffrey; S A C Hawkins; Michael Dawson; James Hope
High prevalence of scrapie in a dairy goat herd: tissue distribution of disease-associated PrP and effect of PRNP genotype and age.
Veterinary research 2009;40(6):65.
2009: Yue Tang; Wei Xiang; Steve A C Hawkins; Hans A Kretzschmar; Otto Windl
Transcriptional changes in the brains of cattle orally infected with the bovine spongiform encephalopathy agent precede detection of infectivity.
Journal of virology 2009;83(18):9464-73.
2009: Saira Cawthraw; Ginny C Saunders; Trevor C Martin; Jason Sawyer; Otto Windl; Scott D Reaney
Real-time PCR detection and identification of prohibited mammalian and avian material in animal feeds.
Journal of food protection 2009;72(5):1055-62.
2009: Ginny C Saunders; Saira Cawthraw; Susan J Mountjoy; Anna C Tout; Anthony R Sayers; James Hope; Otto Windl
Ovine PRNP untranslated region and promoter haplotype diversity.
The Journal of general virology 2009;90(Pt 5):1289-93.
2008: Umberto Agrimi; Romolo Nonno; Giacomo Dell'Omo; Michele Angelo Di Bari; Michela Conte; Barbara Chiappini; Elena Esposito; Giovanni Di Guardo; Otto Windl; Gabriele Vaccari; Hans-Peter Lipp
Prion protein amino acid determinants of differential susceptibility and molecular feature of prion strains in mice and voles.
PLoS pathogens 2008;4(7):e1000113.
2008: Sigrun Roeber; Eva Grasbon-Frodl; Otto Windl; Bjarne Krebs; Wei Xiang; Caren Vollmert; Thomas Illig; Andreas Schröter; Thomas Arzberger; Petra Frick; Inga Zerr; Hans A Kretzschmar
Evidence for a pathogenic role of different mutations at codon 188 of PRNP.
PloS one 2008;3(5):e2147.
2007: Wei Xiang; Manuela Hummel; Gerda Mitteregger; Claudia Pace; Otto Windl; Ulrich Mansmann; Hans A Kretzschmar
Transcriptome analysis reveals altered cholesterol metabolism during the neurodegeneration in mouse scrapie model.
Journal of neurochemistry 2007;102(3):834-47.
2006: C Vollmert; Otto Windl; Wei Xiang; Albert Rosenberger; I Zerr; H-E Wichmann; Heike Bickeböller; Thomas Illig; Hans A Kretzschmar
Significant association of a M129V independent polymorphism in the 5' UTR of the PRNP gene with sporadic Creutzfeldt-Jakob disease in a large German case-control study.
Journal of medical genetics 2006;43(10):e53.
2006: Niklas Piening; Romolo Nonno; Michele Angelo Di Bari; Stephanie Walter; Otto Windl; Umberto Agrimi; Hans A Kretzschmar; Uwe Bertsch
Conversion efficiency of bank vole prion protein in vitro is determined by residues 155 and 170, but does not correlate with the high susceptibility of bank voles to sheep scrapie in vivo.
The Journal of biological chemistry 2006;281(14):9373-84.
2005: Otto Windl; Malte Buchholz; Antonie Neubauer; Walter Schulz-Schaeffer; Martin H Groschup; S Walter; S Arendt; M Neumann; A K Voss; Hans A Kretzschmar
Breaking an absolute species barrier: transgenic mice expressing the mink PrP gene are susceptible to transmissible mink encephalopathy.
Journal of virology 2005;79(23):14971-5.
2005: Constanze Boesenberg; Walter Schulz-Schaeffer; Bettina Meissner; Kai Kallenberg; Mario Bartl; Uta Heinemann; Anna Krasnianski; Katharina Stoeck; Daniela Varges; Otto Windl; Hans A Kretzschmar; Inga Zerr
Clinical course in young patients with sporadic Creutzfeldt-Jakob disease.
Annals of neurology 2005;58(4):533-43.
2005: Wei Xiang; Otto Windl; Ingo M Westner; Manuela Neumann; Inga Zerr; Rosa M Lederer; Hans A Kretzschmar
Cerebral gene expression profiles in sporadic Creutzfeldt-Jakob disease.
Annals of neurology 2005;58(2):242-57.
2005: Claudia Cartoni; Maria Eugenia Schininà; Bruno Maras; Romolo Nonno; Gabriele Vaccari; M A Di Baria; Michela Conte; Q G Liu; M Lu; Franco Cardone; Otto Windl; Maurizio Pocchiari; Umberto Agrimi
Identification of the pathological prion protein allotypes in scrapie-infected heterozygous bank voles (Clethrionomys glareolus) by high-performance liquid chromatography-mass spectrometry.
Journal of chromatography. A 2005;1081(1):122-6.
2005: Neville Vassallo; Jochen Herms; Christina Behrens; Bjarne Krebs; Keiichi Saeki; Takashi Onodera; Otto Windl; Hans A Kretzschmar
Activation of phosphatidylinositol 3-kinase by cellular prion protein and its role in cell survival.
Biochemical and biophysical research communications 2005;332(1):75-82.
2005: Bjarne Krebs; Rosa-Maria Lederer; Otto Windl; Eva Grasbon-Frodl; Inga Zerr; Hans A Kretzschmar
Creutzfeldt-Jakob disease associated with an R148H mutation of the prion protein gene.
Neurogenetics 2005;6(2):97-100.
2005: Sigrun Roeber; Bjarne Krebs; Manuela Neumann; Otto Windl; Inga Zerr; Eva Grasbon-Frodl; Hans A Kretzschmar
Creutzfeldt-Jakob disease in a patient with an R208H mutation of the prion protein gene (PRNP) and a 17-kDa prion protein fragment.
Acta neuropathologica 2005;109(4):443-8.
2004: Bettina Drisaldi; Janaky Coomaraswamy; Peter Mastrangelo; Bob Strome; Jing Yang; Joel C Watts; M Azhar Chishti; Melissa Marvi; Otto Windl; Rosemary Ahrens; François Major; Man-Sun Sy; Hans A Kretzschmar; Paul E Fraser; Howard T J Mount; David Westaway
Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region.
The Journal of biological chemistry 2004;279(53):55443-54.
2004: Eva Grasbon-Frodl; Holger Lorenz; U Mann; Roger M Nitsch; Otto Windl; Hans A Kretzschmar
Loss of glycosylation associated with the T183A mutation in human prion disease.
Acta neuropathologica 2004;108(6):476-84.
2004: Eva Grasbon-Frodl; Rüdiger Schmalzbauer; Petra Frick; Bjarne Krebs; Otto Windl; Inga Zerr; Hans A Kretzschmar
A novel three extra-repeat insertion in the prion protein gene (PRNP) in a patient with Creutzfeldt-Jakob disease.
Neurogenetics 2004;5(4):249-50.
2004: Wei Xiang; Otto Windl; Gerda Wünsch; Martin Dugas; Alexander Kohlmann; Nicola Dierkes; Ingo M Westner; Hans A Kretzschmar
Identification of differentially expressed genes in scrapie-infected mouse brains by using global gene expression technology.
Journal of virology 2004;78(20):11051-60.
2004: Bettina Meissner; K Körtner; Mario Bartl; Ute Jastrow; Brit Mollenhauer; Andreas Schröter; M Finkenstaedt; Otto Windl; Sigrid Poser; Hans A Kretzschmar; Inga Zerr
Sporadic Creutzfeldt-Jakob disease: magnetic resonance imaging and clinical findings.
Neurology 2004;63(3):450-6.
2004: A Harder; A Gregor; T Wirth; F Kreuz; Walter Schulz-Schaeffer; Otto Windl; Michail Plotkin; H Amthauer; K Neukirch; Hans A Kretzschmar; T Kuhlmann; R Braas; H H Hahne; K Jendroska
Early age of onset in fatal familial insomnia. Two novel cases and review of the literature.
Journal of neurology 2004;251(6):715-24.
2004: Markus Otto; Lukas Cepek; Peter Ratzka; S Doehlinger; I Boekhoff; Jens Wiltfang; Eva Irle; G Pergande; B Ellers-Lenz; Otto Windl; Hans A Kretzschmar; Sigrid Poser; Hilmar Prange
Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study.
Neurology 2004;62(5):714-8.
2003: Hans A Kretzschmar; Shneh Sethi; Zsuzsanna Földvári; Otto Windl; Veronika Querner; Inga Zerr; Sigrid Poser
Latrogenic Creutzfeldt-Jakob disease with florid plaques.
Brain pathology (Zurich, Switzerland) 2003;13(3):245-9.
2002: Henriette J Tschampa; Jochen Herms; Walter Schulz-Schaeffer; Brigitte Maruschak; Otto Windl; Ute Jastrow; Inga Zerr; Bernhard J Steinhoff; Sigrid Poser; Hans A Kretzschmar
Clinical findings in sporadic Creutzfeldt-Jakob disease correlate with thalamic pathology.
Brain : a journal of neurology 2002;125(Pt 11):2558-66.
2002: C Wegner; A Römer; Rüdiger Schmalzbauer; Holger Lorenz; Otto Windl; Hans A Kretzschmar
Mutant prion protein acquires resistance to protease in mouse neuroblastoma cells.
The Journal of general virology 2002;83(Pt 5):1237-45.
2002: Holger Lorenz; Otto Windl; Hans A Kretzschmar
Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases.
The Journal of biological chemistry 2002;277(10):8508-16.
2001: Michael L Kramer; Hartmut Kratzin; Bernhard Schmidt; A Römer; Otto Windl; S Liemann; Simone Hornemann; Hans A Kretzschmar
Prion protein binds copper within the physiological concentration range.
The Journal of biological chemistry 2001;276(20):16711-9.
2001: Manfred Oehmichen; Walter Schulz-Schaeffer; Hans A Kretzschmar; I Theuerkauf; I Gerling; Otto Windl; Christoph Meissner
Creutzfeldt-Jakob disease (CJD) in a case of suspected chronic heavy metal poisoning.
Journal of forensic sciences 2001;46(3):702-7.
2000: Inga Zerr; Walter Schulz-Schaeffer; Armin Giese; Monika Bodemer; Andreas Schröter; Karsten Henkel; Henriette J Tschampa; Otto Windl; A Pfahlberg; Bernhard J Steinhoff; Olaf Gefeller; Hans A Kretzschmar; Sigrid Poser
Current clinical diagnosis in Creutzfeldt-Jakob disease: identification of uncommon variants.
Annals of neurology 2000;48(3):323-9.
2000: Markus Otto; Hermann Esselmann; W Schulz-Shaeffer; Manuela Neumann; Andreas Schröter; Peter Ratzka; Lukas Cepek; Inga Zerr; Petra Steinacker; Otto Windl; Johannes Kornhuber; Hans A Kretzschmar; Sigrid Poser; Jens Wiltfang
Decreased beta-amyloid1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Neurology 2000;54(5):1099-102.
1999: A Harder; K Jendroska; F Kreuz; T Wirth; C Schafranka; N Karnatz; A Théallier-Janko; J Dreier; K Lohan; D Emmerich; J Cervós-Navarro; Otto Windl; Hans A Kretzschmar; Peter Nürnberg; R Witkowski
Novel twelve-generation kindred of fatal familial insomnia from germany representing the entire spectrum of disease expression.
American journal of medical genetics 1999;87(4):311-6.
1999: KH Skworc; Otto Windl; Walter Schulz-Schaeffer; Armin Giese; J Bergk; A Nägele; Peter Vieregge; Inga Zerr; Sigrid Poser; Hans A Kretzschmar
Familial Creutzfeldt-Jakob disease with a novel 120-bp insertion in the prion protein gene.
Annals of neurology 1999;46(5):693-700.
1999: Jochen Herms; Tobias Tings; S Gall; A Madlung; Armin Giese; Heike Siebert; P Schürmann; Otto Windl; Nils Brose; Hans A Kretzschmar
Evidence of presynaptic location and function of the prion protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(20):8866-75.
1999: Otto Windl; Armin Giese; Walter Schulz-Schaeffer; Inga Zerr; KH Skworc; S Arendt; C Oberdieck; Monika Bodemer; Sigrid Poser; Hans A Kretzschmar
Molecular genetics of human prion diseases in Germany.
Human genetics 1999;105(3):244-52.
1999: Piero Parchi; A Giese; Sabina Capellari; P Brown; Walter Schulz-Schaeffer; Otto Windl; I Zerr; Herbert Budka; Nicolas Kopp; Pedro Piccardo; S Poser; A Rojiani; N Streichemberger; J Julien; Claude Vital; Bernardino Ghetti; Pierluigi Gambetti; Hans A Kretzschmar
Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects.
Annals of neurology 1999;46(2):224-33.
1999: Otto Windl; Holger Lorenz; C Behrens; A Römer; Hans A Kretzschmar
Construction and characterization of murine neuroblastoma cell clones allowing inducible and high expression of the prion protein.
The Journal of general virology 1999;80 ( Pt 1)():15-21.
1999: Stefan Kropp; Walter Schulz-Schaeffer; M Finkenstaedt; C Riedemann; Otto Windl; Bernhard J Steinhoff; Inga Zerr; Hans A Kretzschmar; Sigrid Poser
The Heidenhain variant of Creutzfeldt-Jakob disease.
Archives of neurology 1999;56(1):55-61.
1998: Inga Zerr; Armin Giese; Otto Windl; Stefan Kropp; Walter Schulz-Schaeffer; C Riedemann; KH Skworc; Monika Bodemer; Hans A Kretzschmar; Sigrid Poser
Phenotypic variability in fatal familial insomnia (D178N-129M) genotype.
Neurology 1998;51(5):1398-405.
1998: Hans A Kretzschmar; Armin Giese; Inga Zerr; Otto Windl; Walter Schulz-Schaeffer; KH Skworc; Sigrid Poser
The German FFI cases.
Brain pathology (Zurich, Switzerland) 1998;8(3):559-61.
1998: Inga Zerr; Monika Bodemer; Olaf Gefeller; Markus Otto; Sigrid Poser; Jens Wiltfang; Otto Windl; Hans A Kretzschmar; T Weber
Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease.
Annals of neurology 1998;43(1):32-40.
1996: J Weis; Hans A Kretzschmar; Otto Windl; K Podoll; M Schwarz
Fatal spongiform encephalopathy in a patient who had handled animal feed.
Lancet 1996;348(9036):1240.
1996: Walter Schulz-Schaeffer; Armin Giese; Otto Windl; Hans A Kretzschmar
Polymorphism at codon 129 of the prion protein gene determines cerebellar pathology in Creutzfeldt-Jakob disease.
Clinical neuropathology 1996;15(6):353-7.
1996: Inga Zerr; Monika Bodemer; Markus Otto; Sigrid Poser; Otto Windl; Hans A Kretzschmar; Olaf Gefeller; T Weber
Diagnosis of Creutzfeldt-Jakob disease by two-dimensional gel electrophoresis of cerebrospinal fluid.
Lancet 1996;348(9031):846-9.
1996: Otto Windl; M Dempster; J P Estibeiro; Richard Lathe; R De Silva; T Esmonde; Robert Will; A Springbett; Tracy A Campbell; K C Sidle; M S Palmer; John Collinge
Genetic basis of Creutzfeldt-Jakob disease in the United Kingdom: a systematic analysis of predisposing mutations and allelic variation in the PRNP gene.
Human genetics 1996;98(3):259-64.
1995: Otto Windl; M Dempster; P Estibeiro; Richard Lathe
A candidate marsupial PrP gene reveals two domains conserved in mammalian PrP proteins.
Gene 1995;159(2):181-6.
1995: D Nicholl; Otto Windl; R De Silva; S Sawcer; M Dempster; James W Ironside; J P Estibeiro; G M Yuill; Richard Lathe; Robert G Will
Inherited Creutzfeldt-Jakob disease in a British family associated with a novel 144 base pair insertion of the prion protein gene.
Journal of neurology, neurosurgery, and psychiatry 1995;58(1):65-9.
1994: R De Silva; James W Ironside; Linda McCardle; T Esmonde; J Bell; Robert Will; Otto Windl; M Dempster; P Estibeiro; Richard Lathe
Neuropathological phenotype and 'prion protein' genotype correlation in sporadic Creutzfeldt-Jakob disease.
Neuroscience letters 1994;179(1-2):50-2.