David Wink

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Jackson Matthew I; Han Tae H; Serbulea Laura; Dutton Andrew; Ford Eleonora; Miranda Katrina M; Houk K N; Wink David A; Fukuto Jon M
Kinetic feasibility of nitroxyl reduction by physiological reductants and biological implications.
Flores-Santana Wilmarie; Switzer Christopher; Ridnour Lisa A; Basudhar Debashree; Mancardi Daniele; Donzelli Sonia; Thomas Douglas D; Miranda Katrina M; Fukuto Jon M; Wink David A
Comparing the chemical biology of NO and HNO.
MacDonald Christopher J; Cheng Robert Y S; Roberts David D; Wink David A; Yeh Grace Chao
Modulation of carcinogen metabolism by nitric oxide-aspirin 2 is associated with suppression of DNA damage and DNA adduct formation.

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All Publications

2009: Jackson Matthew I; Han Tae H; Serbulea Laura; Dutton Andrew; Ford Eleonora; Miranda Katrina M; Houk K N; Wink David A; Fukuto Jon M
Kinetic feasibility of nitroxyl reduction by physiological reductants and biological implications.
Free radical biology & medicine 2009;47(8):1130-9.
2009: Flores-Santana Wilmarie; Switzer Christopher; Ridnour Lisa A; Basudhar Debashree; Mancardi Daniele; Donzelli Sonia; Thomas Douglas D; Miranda Katrina M; Fukuto Jon M; Wink David A
Comparing the chemical biology of NO and HNO.
Archives of pharmacal research 2009;32(8):1139-53.
2009: MacDonald Christopher J; Cheng Robert Y S; Roberts David D; Wink David A; Yeh Grace Chao
Modulation of carcinogen metabolism by nitric oxide-aspirin 2 is associated with suppression of DNA damage and DNA adduct formation.
The Journal of biological chemistry 2009;284(33):22099-107.
2009: Samuni Yuval; Flores-Santana Wilmarie; Krishna Murali C; Mitchell James B; Wink David A
The inhibitors of histone deacetylase suberoylanilide hydroxamate and trichostatin A release nitric oxide upon oxidation.
Free radical biology & medicine 2009;47(4):419-23.
2009: Switzer Christopher H; Flores-Santana Wilmarie; Mancardi Daniele; Donzelli Sonia; Basudhar Debashree; Ridnour Lisa A; Miranda Katrina M; Fukuto Jon M; Paolocci Nazareno; Wink David A
The emergence of nitroxyl (HNO) as a pharmacological agent.
Biochimica et biophysica acta 2009;1787(7):835-40.
2009: Glynn Sharon A; Boersma Brenda J; Howe Tiffany M; Edvardsen Hege; Geisler Stephanie B; Goodman Julie E; Ridnour Lisa A; Lønning Per E; Børresen-Dale Anne-Lise; Naume Bjorn; Kristensen Vessela N; Chanock Stephen J; Wink David A; Ambs Stefan
A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(12):4165-73.
2009: Bass Sara E; Sienkiewicz Pawel; Macdonald Christopher J; Cheng Robert Y S; Sparatore Anna; Del Soldato Piero; Roberts David D; Moody Terry W; Wink David A; Yeh Grace Chao
Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(6):1964-72.
2008: Isenberg Jeff S; Frazier William A; Krishna Murali C; Wink David A; Roberts David D
Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling.
Current drug targets 2008;9(10):833-41.
2008: Isenberg Jeff S; Maxhimer Justin B; Hyodo Fuminori; Pendrak Michael L; Ridnour Lisa A; DeGraff William G; Tsokos Maria; Wink David A; Roberts David D
Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury.
The American journal of pathology 2008;173(4):1100-12.
2008: Dai Shujia; Jia Yifeng; Wu Shiaw-Lin; Isenberg Jeff S; Ridnour Lisa A; Bandle Russell W; Wink David A; Roberts David D; Karger Barry L
Comprehensive characterization of heat shock protein 27 phosphorylation in human endothelial cells stimulated by the microbial dithiole thiolutin.
Journal of proteome research 2008;7(10):4384-95.
2008: Martin-Manso Gema; Galli Susana; Ridnour Lisa A; Tsokos Maria; Wink David A; Roberts David D
Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells.
Cancer research 2008;68(17):7090-9.
2008: Wink David A; Ridnour Lisa A; Hussain S Perwez; Harris Curtis C
The reemergence of nitric oxide and cancer.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2008;19(2):65-7.
2008: Donzelli Sonia; Espey Michael Graham; Flores-Santana Wilmarie; Switzer Christopher H; Yeh Grace C; Huang Jinming; Stuehr Dennis J; King S Bruce; Miranda Katrina M; Wink David A
Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine.
Free radical biology & medicine 2008;45(5):578-84.
2008: Ridnour Lisa A; Thomas Douglas D; Switzer Christopher; Flores-Santana Wilmarie; Isenberg Jeffrey S; Ambs Stefan; Roberts David D; Wink David A
Molecular mechanisms for discrete nitric oxide levels in cancer.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2008;19(2):73-6.
2008: Isenberg Jeff S; Hyodo Fuminori; Ridnour Lisa A; Shannon Caitlin S; Wink David A; Krishna Murali C; Roberts David D
Thrombospondin 1 and vasoactive agents indirectly alter tumor blood flow.
Neoplasia (New York, N.Y.) 2008;10(8):886-96.
2008: Thomas Douglas D; Ridnour Lisa A; Isenberg Jeffrey S; Flores-Santana Wilmarie; Switzer Christopher H; Donzelli Sonia; Hussain Perwez; Vecoli Cecilia; Paolocci Nazareno; Ambs Stefan; Colton Carol A; Harris Curtis C; Roberts David D; Wink David A
The chemical biology of nitric oxide: implications in cellular signaling.
Free radical biology & medicine 2008;45(1):18-31.
2008: Matsumoto Shingo; Espey Michael Graham; Utsumi Hideo; Devasahayam Nallathamby; Matsumoto Ken-Ichiro; Matsumoto Atsuko; Hirata Hiroshi; Wink David A; Kuppusamy Periannan; Subramanian Sankaran; Mitchell James B; Krishna Murali C
Dynamic monitoring of localized tumor oxygenation changes using RF pulsed electron paramagnetic resonance in conscious mice.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2008;59(3):619-25.
2008: Isenberg Jeff S; Pappan Loretta K; Romeo Martin J; Abu-Asab Mones; Tsokos Maria; Wink David A; Frazier William A; Roberts David D
Blockade of thrombospondin-1-CD47 interactions prevents necrosis of full thickness skin grafts.
Annals of surgery 2008;247(1):180-90.
2008: Isenberg Jeff S; Romeo Martin J; Yu Christine; Yu Christine K; Nghiem Khauh; Monsale Jude; Rick Margaret E; Wink David A; Frazier William A; Roberts David D
Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling.
Blood 2008;111(2):613-23.
2007: Ridnour Lisa A; Windhausen Alisha N; Isenberg Jeffrey S; Yeung Nolan; Thomas Douglas D; Vitek Michael P; Roberts David D; Wink David A
Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):16898-903.
2007: Lopez Brenda E; Wink David A; Fukuto Jon M
The inhibition of glyceraldehyde-3-phosphate dehydrogenase by nitroxyl (HNO).
Archives of biochemistry and biophysics 2007;465(2):430-6.
2007: Isenberg Jeff S; Jia Yifeng; Fukuyama Julia; Switzer Christopher H; Wink David A; Roberts David D
Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake.
The Journal of biological chemistry 2007;282(21):15404-15.
2007: Isenberg J S; Jia Y; Field L; Ridnour L A; Sparatore A; Del Soldato P; Sowers A L; Yeh G C; Moody T W; Wink D A; Ramchandran R; Roberts D D
Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid.
British journal of pharmacology 2007;151(1):63-72.
2007: Isenberg Jeff S; Romeo Martin J; Abu-Asab Mones; Tsokos Maria; Oldenborg Anna; Pappan Loretta; Wink David A; Frazier William A; Roberts David D
Increasing survival of ischemic tissue by targeting CD47.
Circulation research 2007;100(5):712-20.
2007: Isenberg Jeff S; Hyodo Fuminori; Matsumoto Ken-Ichiro; Romeo Martin J; Abu-Asab Mones; Tsokos Maria; Kuppusamy Periannan; Wink David A; Krishna Murali C; Roberts David D
Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation.
Blood 2007;109(5):1945-52.
2007: Roberts David D; Isenberg Jeffery S; Ridnour Lisa A; Wink David A
Nitric oxide and its gatekeeper thrombospondin-1 in tumor angiogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(3):795-8.
2007: Paolocci Nazareno; Jackson Matthew I; Lopez Brenda E; Miranda Katrina; Tocchetti Carlo G; Wink David A; Hobbs Adrian J; Fukuto Jon M
The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NO.
Pharmacology & therapeutics 2007;113(2):442-58.
2007: Prueitt Robyn L; Boersma Brenda J; Howe Tiffany M; Goodman Julie E; Thomas Douglas D; Ying Lei; Pfiester Candice M; Yfantis Harris G; Cottrell John R; Lee Dong H; Remaley Alan T; Hofseth Lorne J; Wink David A; Ambs Stefan
Inflammation and IGF-I activate the Akt pathway in breast cancer.
International journal of cancer. Journal international du cancer 2007;120(4):796-805.
2007: Tocchetti Carlo G; Wang Wang; Froehlich Jeffrey P; Huke Sabine; Aon Miguel A; Wilson Gerald M; Di Benedetto Giulietta; O'Rourke Brian; Gao Wei Dong; Wink David A; Toscano John P; Zaccolo Manuela; Bers Donald M; Valdivia Hector H; Cheng Heping; Kass David A; Paolocci Nazareno
Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling.
Circulation research 2007;100(1):96-104.
2006: Thomas Douglas D; Espey Michael G; Pociask Derek A; Ridnour Lisa A; Donzelli Sonia; Wink David A
Asbestos redirects nitric oxide signaling through rapid catalytic conversion to nitrite.
Cancer research 2006;66(24):11600-4.
2006: Katori Tatsuo; Donzelli Sonia; Tocchetti Carlo G; Miranda Katrina M; Cormaci Gianfrancesco; Thomas Douglas D; Ketner Elizabeth A; Lee Myung Jae; Mancardi Daniele; Wink David A; Kass David A; Paolocci Nazareno
Peroxynitrite and myocardial contractility: in vivo versus in vitro effects.
Free radical biology & medicine 2006;41(10):1606-18.
2006: Isenberg Jeff S; Ridnour Lisa A; Dimitry Julie; Frazier William A; Wink David A; Roberts David D
CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1.
The Journal of biological chemistry 2006;281(36):26069-80.
2006: Thomas Douglas D; Ridnour Lisa A; Espey Michael Graham; Donzelli Sonia; Ambs Stefan; Hussain S Perwez; Harris Curtis C; DeGraff William; Roberts David D; Mitchell James B; Wink David A
Superoxide fluxes limit nitric oxide-induced signaling.
The Journal of biological chemistry 2006;281(36):25984-93.
2006: Isenberg Jeff S; Wink David A; Roberts David D
Thrombospondin-1 antagonizes nitric oxide-stimulated vascular smooth muscle cell responses.
Cardiovascular research 2006;71(4):785-93.
2006: Donzelli Sonia; Switzer Christopher H; Thomas Douglas D; Ridnour Lisa A; Espey Michael Graham; Isenberg Jeffrey S; Tocchetti Carlo G; King S Bruce; Lazzarino Giuseppe; Miranda Katrina M; Roberts David D; Feelisch Martin; Wink David A
The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling.
Antioxidants & redox signaling 2006;8(7-8):1363-71.
2006: Ridnour Lisa A; Thomas Douglas D; Donzelli Sonia; Espey Michael G; Roberts David D; Wink David A; Isenberg Jeffrey S
The biphasic nature of nitric oxide responses in tumor biology.
Antioxidants & redox signaling 2006;8(7-8):1329-37.
2006: Donzelli Sonia; Espey Michael Graham; Thomas Douglas D; Mancardi Daniele; Tocchetti Carlo G; Ridnour Lisa A; Paolocci Nazareno; King S Bruce; Miranda Katrina M; Lazzarino Giuseppe; Fukuto Jon M; Wink David A
Discriminating formation of HNO from other reactive nitrogen oxide species.
Free radical biology & medicine 2006;40(6):1056-66.
2006: Isenberg Jeff S; Ridnour Lisa A; Thomas Douglas D; Wink David A; Roberts David D; Espey Michael Graham
Guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide gradients.
Free radical biology & medicine 2006;40(6):1028-33.
2006: Dutton Andrew S; Suhrada Christopher P; Miranda Katrina M; Wink David A; Fukuto Jon M; Houk K N
Mechanism of pH-dependent decomposition of monoalkylamine diazeniumdiolates to form HNO and NO, deduced from the model compound methylamine diazeniumdiolate, density functional theory, and CBS-QB3 calculations.
Inorganic chemistry 2006;45(6):2448-56.
2005: Miranda Katrina M; Katori Tatsuo; Torres de Holding Claudia L; Thomas Lynta; Ridnour Lisa A; McLendon William J; Cologna Stephanie M; Dutton Andrew S; Champion Hunter C; Mancardi Daniele; Tocchetti Carlo G; Saavedra Joseph E; Keefer Larry K; Houk K N; Fukuto Jon M; Kass David A; Paolocci Nazareno; Wink David A
Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo.
Journal of medicinal chemistry 2005;48(26):8220-8.
2005: Hewett Sandra J; Espey Michael G; Uliasz Tracy F; Wink David A
Neurotoxicity of nitroxyl: insights into HNO and NO biochemical imbalance.
Free radical biology & medicine 2005;39(11):1478-88.
2005: Isenberg Jeff S; Ridnour Lisa A; Perruccio Elizabeth M; Espey Michael G; Wink David A; Roberts David D
Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(37):13141-6.
2005: Ridnour Lisa A; Isenberg Jeffrey S; Espey Michael G; Thomas Douglas D; Roberts David D; Wink David A
Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(37):13147-52.
2005: Fukuto Jon M; Bartberger Michael D; Dutton Andrew S; Paolocci Nazareno; Wink David A; Houk K N
The physiological chemistry and biological activity of nitroxyl (HNO): the neglected, misunderstood, and enigmatic nitrogen oxide.
Chemical research in toxicology 2005;18(5):790-801.
2005: Miranda Katrina M; Dutton Andrew S; Ridnour Lisa A; Foreman Christian A; Ford Eleonora; Paolocci Nazareno; Katori Tatsuo; Tocchetti Carlo G; Mancardi Daniele; Thomas Douglas D; Espey Michael G; Houk K N; Fukuto Jon M; Wink David A
Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH.
Journal of the American Chemical Society 2005;127(2):722-31.
2005: Isenberg Jeff S; Ridnour Lisa A; Espey Michael Graham; Wink David A; Roberts David D
Nitric oxide in wound-healing.
Microsurgery 2005;25(5):442-51.
2005: Fukuto Jon M; Switzer Christopher H; Miranda Katrina M; Wink David A
Nitroxyl (HNO): chemistry, biochemistry, and pharmacology.
Annual review of pharmacology and toxicology 2005;45():335-55.
2004: Mancardi Daniele; Ridnour Lisa A; Thomas Douglas D; Katori Tatsuo; Tocchetti Carlo G; Espey Michael G; Miranda Katrina M; Paolocci Nazareno; Wink David A
The chemical dynamics of NO and reactive nitrogen oxides: a practical guide.
Current molecular medicine 2004;4(7):723-40.
2004: Cook John A; Gius David; Wink David A; Krishna Murali C; Russo Angelo; Mitchell James B
Oxidative stress, redox, and the tumor microenvironment.
Seminars in radiation oncology 2004;14(3):259-66.
2004: Thomas Douglas D; Espey Michael Graham; Ridnour Lisa A; Hofseth Lorne J; Mancardi Daniele; Harris Curtis C; Wink David A
Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(24):8894-9.
2004: Ridnour Lisa A; Thomas Douglas D; Mancardi Daniele; Espey Michael G; Miranda Katrina M; Paolocci Nazareno; Feelisch Martin; Fukuto Jon; Wink David A
The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations.
Biological chemistry 2004;385(1):1-10.
2003: Wink David A; Miranda Katrina M; Katori Tatsuo; Mancardi Daniele; Thomas Douglas D; Ridnour Lisa; Espey Michael G; Feelisch Martin; Colton Carol A; Fukuto Jon M; Pagliaro Pasquale; Kass David A; Paolocci Nazareno
Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm.
American journal of physiology. Heart and circulatory physiology 2003;285(6):H2264-76.
2003: Miranda Katrina M; Paolocci Nazareno; Katori Tatsuo; Thomas Douglas D; Ford Eleonora; Bartberger Michael D; Espey Michael G; Kass David A; Feelisch Martin; Fukuto Jon M; Wink David A
A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9196-201.
2003: Thomas Douglas D; Miranda Katrina M; Colton Carol A; Citrin Deborah; Espey Michael Graham; Wink David A
Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation.
Antioxidants & redox signaling 2003;5(3):307-17.
2003: Paolocci Nazareno; Katori Tatsuo; Champion Hunter C; St John Marcus E; Miranda Katrina M; Fukuto Jon M; Wink David A; Kass David A
Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from beta-adrenergic signaling.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5537-42.
2003: Wink David A; Mitchell James B
Nitric oxide and cancer: an introduction.
Free radical biology & medicine 2003;34(8):951-4.
2003: Miranda Katrina M; Nims Raymond W; Thomas Douglas D; Espey Michael G; Citrin Deborah; Bartberger Michael D; Paolocci Nazareno; Fukuto Jon M; Feelisch Martin; Wink David A
Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS.
Journal of inorganic biochemistry 2003;93(1-2):52-60.
2003: Hofseth Lorne J; Saito Shin'ichi; Hussain S Perwez; Espey Michael G; Miranda Katrina M; Araki Yuzuru; Jhappan Chamelli; Higashimoto Yuichiro; He Peijun; Linke Steven P; Quezado Martha M; Zurer Irit; Rotter Varda; Wink David A; Appella Ettore; Harris Curtis C
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):143-8.
2003: Pagliaro Pasquale; Mancardi Daniele; Rastaldo Raffaella; Penna Claudia; Gattullo Donatella; Miranda Katrina M; Feelisch Martin; Wink David A; Kass David A; Paolocci Nazareno
Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning.
Free radical biology & medicine 2003;34(1):33-43.
2002: Thomas Douglas D; Espey Michael Graham; Vitek Michael P; Miranda Katrina M; Wink David A
Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reaction.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12691-6.
2002: Espey Michael Graham; Miranda Katrina M; Thomas Douglas D; Wink David A
Ingress and reactive chemistry of nitroxyl-derived species within human cells.
Free radical biology & medicine 2002;33(6):827-34.
2002: Bartberger Michael D; Liu Wei; Ford Eleonora; Miranda Katrina M; Switzer Christopher; Fukuto Jon M; Farmer Patrick J; Wink David A; Houk Kendall N
The reduction potential of nitric oxide (NO) and its importance to NO biochemistry.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):10958-63.
2002: Espey Michael G; Thomas Douglas D; Miranda Katrina M; Wink David A
Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxide.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11127-32.
2002: Espey Michael G; Miranda Katrina M; Thomas Douglas D; Xavier Sandhya; Citrin Deborah; Vitek Michael P; Wink David A
A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species.
Annals of the New York Academy of Sciences 2002;962():195-206.
2002: Miranda Katrina M; Yamada Ken-ichi; Espey Michael G; Thomas Douglas D; DeGraff William; Mitchell James B; Krishna Murali C; Colton Carol A; Wink David A
Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite.
Archives of biochemistry and biophysics 2002;401(2):134-44.
2002: Espey Michael Graham; Xavier Sandhya; Thomas Douglas D; Miranda Katrina M; Wink David A
Direct real-time evaluation of nitration with green fluorescent protein in solution and within human cells reveals the impact of nitrogen dioxide vs. peroxynitrite mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):3481-6.
2002: Thomas Douglas D; Miranda Katrina M; Espey Michael Graham; Citrin Deborah; Jourd'heuil David; Paolocci Nazareno; Hewett Sandra J; Colton Carol A; Grisham Matthew B; Feelisch Martin; Wink David A
Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems.
Methods in enzymology 2002;359():84-105.
2001: Paolocci N; Saavedra W F; Miranda K M; Martignani C; Isoda T; Hare J M; Espey M G; Fukuto J M; Feelisch M; Wink D A; Kass D A
Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10463-8.
2001: Espey M G; Miranda K M; Thomas D D; Wink D A
Distinction between nitrosating mechanisms within human cells and aqueous solution.
The Journal of biological chemistry 2001;276(32):30085-91.
2001: Wink D A; Miranda K M; Espey M G; Pluta R M; Hewett S J; Colton C; Vitek M; Feelisch M; Grisham M B
Mechanisms of the antioxidant effects of nitric oxide.
Antioxidants & redox signaling 2001;3(2):203-13.
2001: Miranda K M; Espey M G; Wink D A
A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2001;5(1):62-71.
2001: Ogawa R; Pacelli R; Espey M G; Miranda K M; Friedman N; Kim S M; Cox G; Mitchell J B; Wink D A; Russo A
Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and NO donors: insights into listeriocidal activity of oxidative and nitrosative stress.
Free radical biology & medicine 2001;30(3):268-76.
2001: Miranda K M; Espey M G; Yamada K; Krishna M; Ludwick N; Kim S; Jourd'heuil D; Grisham M B; Feelisch M; Fukuto J M; Wink D A
Unique oxidative mechanisms for the reactive nitrogen oxide species, nitroxyl anion.
The Journal of biological chemistry 2001;276(3):1720-7.
2000: Zhou X; Espey M G; Chen J X; Hofseth L J; Miranda K M; Hussain S P; Wink D A; Harris C C
Inhibitory effects of nitric oxide and nitrosative stress on dopamine-beta-hydroxylase.
The Journal of biological chemistry 2000;275(28):21241-6.
2000: Miranda K M; Espey M G; Wink D A
A discussion of the chemistry of oxidative and nitrosative stress in cytotoxicity.
Journal of inorganic biochemistry 2000;79(1-4):237-40.
2000: Espey M G; Miranda K M; Pluta R M; Wink D A
Nitrosative capacity of macrophages is dependent on nitric-oxide synthase induction signals.
The Journal of biological chemistry 2000;275(15):11341-7.
2000: Wink D A; Miranda K M; Espey M G
Effects of oxidative and nitrosative stress in cytotoxicity.
Seminars in perinatology 2000;24(1):20-3.
2000: Espey M G; Miranda K M; Feelisch M; Fukuto J; Grisham M B; Vitek M P; Wink D A
Mechanisms of cell death governed by the balance between nitrosative and oxidative stress.
Annals of the New York Academy of Sciences 2000;899():209-21.
2000: McKinney L C; Aquilla E M; Coffin D; Wink D A; Vodovotz Y
Ionizing radiation potentiates the induction of nitric oxide synthase by interferon-gamma and/or lipopolysaccharide in murine macrophage cell lines. Role of tumor necrosis factor-alpha.
Annals of the New York Academy of Sciences 2000;899():61-8.
1999: Gbadegesin M; Vicini S; Hewett S J; Wink D A; Espey M; Pluta R M; Colton C A
Hypoxia modulates nitric oxide-induced regulation of NMDA receptor currents and neuronal cell death.
The American journal of physiology 1999;277(4 Pt 1):C673-83.
1999: Okayama N; Grisham M B; Kevil C G; Eppihimer L A; Wink D A; Alexander J S
Effect of reactive oxygen metabolites on endothelial permeability: role of nitric oxide and iron.
Microcirculation (New York, N.Y. : 1994) 1999;6(2):107-16.
1999: Vodovotz Y; Chesler L; Chong H; Kim S J; Simpson J T; DeGraff W; Cox G W; Roberts A B; Wink D A; Barcellos-Hoff M H
Regulation of transforming growth factor beta1 by nitric oxide.
Cancer research 1999;59(9):2142-9.
1999: Jourd'heuil D; Miranda K M; Kim S M; Espey M G; Vodovotz Y; Laroux S; Mai C T; Miles A M; Grisham M B; Wink D A
The oxidative and nitrosative chemistry of the nitric oxide/superoxide reaction in the presence of bicarbonate.
Archives of biochemistry and biophysics 1999;365(1):92-100.
1999: Vidwans A S; Kim S; Coffin D O; Wink D A; Hewett S J
Analysis of the neuroprotective effects of various nitric oxide donor compounds in murine mixed cortical cell culture.
Journal of neurochemistry 1999;72(5):1843-52.
1999: Grisham M B; Jourd'Heuil D; Wink D A
Nitric oxide. I. Physiological chemistry of nitric oxide and its metabolites:implications in inflammation.
The American journal of physiology 1999;276(2 Pt 1):G315-21.
1999: Jourd'heuil D; Laroux F S; Miles A M; Wink D A; Grisham M B
Effect of superoxide dismutase on the stability of S-nitrosothiols.
Archives of biochemistry and biophysics 1999;361(2):323-30.
1999: Vodovotz Y; Coffin D; DeLuca A M; McKinney L; Cook J A; Wink D; Mitchell J B
Induction of nitric oxide production in infiltrating leukocytes following in vivo irradiation of tumor-bearing mice.
Radiation oncology investigations 1999;7(2):86-97.
1999: Wink D A; Vodovotz Y; Grisham M B; DeGraff W; Cook J C; Pacelli R; Krishna M; Mitchell J B
Antioxidant effects of nitric oxide.
Methods in enzymology 1999;301():413-24.
1999: Jourd'heuil D; Laroux F S; Kang D; Miles A M; Wink D A; Grisham M B
Stability of S-nitrosothiols in presence of copper, zinc-superoxide dismutase.
Methods in enzymology 1999;301():220-7.
1999: Wink D A; Kim S; Coffin D; Cook J C; Vodovotz Y; Chistodoulou D; Jourd'heuil D; Grisham M B
Detection of S-nitrosothiols by fluorometric and colorimetric methods.
Methods in enzymology 1999;301():201-11.
1998: Mitchell J B; DeGraff W; Kim S; Cook J A; Gamson J; Christodoulou D; Feelisch M; Wink D A
Redox generation of nitric oxide to radiosensitize hypoxic cells.
International journal of radiation oncology, biology, physics 1998;42(4):795-8.
1998: McKinney L C; Aquilla E M; Coffin D; Wink D A; Vodovotz Y
Ionizing radiation potentiates the induction of nitric oxide synthase by IFN-gamma and/or LPS in murine macrophage cell lines: role of TNF-alpha.
Journal of leukocyte biology 1998;64(4):459-66.
1998: Wink D A; Mitchell J B
Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide.
Free radical biology & medicine 1998;25(4-5):434-56.
1998: Wink D A; Vodovotz Y; Cook J A; Krishna M C; Kim S; Coffin D; DeGraff W; Deluca A M; Liebmann J; Mitchell J B
The role of nitric oxide chemistry in cancer treatment.
Biochemistry. Biokhimii?a 1998;63(7):802-9.
1998: Wink D A; Vodovotz Y; Laval J; Laval F; Dewhirst M W; Mitchell J B
The multifaceted roles of nitric oxide in cancer.
Carcinogenesis 1998;19(5):711-21.
1998: Jourd'heuil D; Mai C T; Laroux F S; Wink D A; Grisham M B
The reaction of S-nitrosoglutathione with superoxide.
Biochemical and biophysical research communications 1998;246(3):525-30.
1998: Jourd'heuil D; Mai C T; Laroux F S; Wink D A; Grisham M B
The reaction of S-nitrosoglutathione with superoxide.
Biochemical and biophysical research communications 1998;244(2):525-30.
1998: Wink D A; Feelisch M; Fukuto J; Chistodoulou D; Jourd'heuil D; Grisham M B; Vodovotz Y; Cook J A; Krishna M; DeGraff W G; Kim S; Gamson J; Mitchell J B
The cytotoxicity of nitroxyl: possible implications for the pathophysiological role of NO.
Archives of biochemistry and biophysics 1998;351(1):66-74.
1998: Vodovotz Y; Kopp J B; Takeguchi H; Shrivastav S; Coffin D; Lucia M S; Mitchell J B; Webber R; Letterio J; Wink D; Roberts A B
Increased mortality, blunted production of nitric oxide, and increased production of TNF-alpha in endotoxemic TGF-beta1 transgenic mice.
Journal of leukocyte biology 1998;63(1):31-9.
1997: Wink D A; Cook J A; Kim S Y; Vodovotz Y; Pacelli R; Krishna M C; Russo A; Mitchell J B; Jourd'heuil D; Miles A M; Grisham M B
Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates. Chemical aspects involved in the balance between oxidative and nitrosative stress.
The Journal of biological chemistry 1997;272(17):11147-51.
1997: Wink D A; Cook J A; Christodoulou D; Krishna M C; Pacelli R; Kim S; DeGraff W; Gamson J; Vodovotz Y; Russo A; Mitchell J B
Nitric oxide and some nitric oxide donor compounds enhance the cytotoxicity of cisplatin.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 1997;1(1):88-94.
1997: Cook J A; Krishna M C; Pacelli R; DeGraff W; Liebmann J; Mitchell J B; Russo A; Wink D A
Nitric oxide enhancement of melphalan-induced cytotoxicity.
British journal of cancer 1997;76(3):325-34.
1996: Mitchell J B; Cook J A; Krishna M C; DeGraff W; Gamson J; Fisher J; Christodoulou D; Wink D A
Radiation sensitisation by nitric oxide releasing agents.
The British journal of cancer. Supplement 1996;27():S181-4.
1996: Wink D A; Cook J A; Pacelli R; DeGraff W; Gamson J; Liebmann J; Krishna M C; Mitchell J B
The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: a direct correlation between nitric oxide formation and protection.
Archives of biochemistry and biophysics 1996;331(2):241-8.
1996: Cook J A; Kim S Y; Teague D; Krishna M C; Pacelli R; Mitchell J B; Vodovotz Y; Nims R W; Christodoulou D; Miles A M; Grisham M B; Wink D A
Convenient colorimetric and fluorometric assays for S-nitrosothiols.
Analytical biochemistry 1996;238(2):150-8.
1996: Pacelli R; Taira J; Cook J A; Wink D A; Krishna M C
Hydroxyurea reacts with heme proteins to generate nitric oxide.
Lancet 1996;347(9005):900.
1996: Miles A M; Bohle D S; Glassbrenner P A; Hansert B; Wink D A; Grisham M B
Modulation of superoxide-dependent oxidation and hydroxylation reactions by nitric oxide.
The Journal of biological chemistry 1996;271(1):40-7.
1996: Keefer L K; Nims R W; Davies K M; Wink D A
"NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms.
Methods in enzymology 1996;268():281-93.
1996: Wink D A; Grisham M B; Miles A M; Nims R W; Krishna M C; Pacelli R; Teague D; Poore C M; Cook J A; Ford P C
Determination of selectivity of reactive nitrogen oxide species for various substrates.
Methods in enzymology 1996;268():120-30.
1996: Miles A M; Wink D A; Cook J C; Grisham M B
Determination of nitric oxide using fluorescence spectroscopy.
Methods in enzymology 1996;268():105-20.
1996: Nims R W; Cook J C; Krishna M C; Christodoulou D; Poore C M; Miles A M; Grisham M B; Wink D A
Colorimetric assays for nitric oxide and nitrogen oxide species formed from nitric oxide stock solutions and donor compounds.
Methods in enzymology 1996;268():93-105.
1996: Christodoulou D; Kudo S; Cook J A; Krishna M C; Miles A; Grisham M B; Murugesan M; Ford P C; Wink D A
Electrochemical methods for detection of nitric oxide.
Methods in enzymology 1996;268():69-83.
1996: Wink D A; Grisham M B; Mitchell J B; Ford P C
Direct and indirect effects of nitric oxide in chemical reactions relevant to biology.
Methods in enzymology 1996;268():12-31.
1996: Wink D A; Hanbauer I; Grisham M B; Laval F; Nims R W; Laval J; Cook J; Pacelli R; Liebmann J; Krishna M; Ford P C; Mitchell J B
Chemical biology of nitric oxide: regulation and protective and toxic mechanisms.
Current topics in cellular regulation 1996;34():159-87.
1995: Wink D A; Cook J A; Pacelli R; Liebmann J; Krishna M C; Mitchell J B
Nitric oxide (NO) protects against cellular damage by reactive oxygen species.
Toxicology letters 1995;82-83():221-6.
1995: Pacelli R; Wink D A; Cook J A; Krishna M C; DeGraff W; Friedman N; Tsokos M; Samuni A; Mitchell J B
Nitric oxide potentiates hydrogen peroxide-induced killing of Escherichia coli.
The Journal of experimental medicine 1995;182(5):1469-79.
1995: Miles A M; Gibson M F; Kirshina M; Cook J C; Pacelli R; Wink D; Grisham M B
Effects of superoxide on nitric oxide-dependent N-nitrosation reactions.
Free radical research 1995;23(4):379-90.
1995: Wink D A; Cook J A; Krishna M C; Hanbauer I; DeGraff W; Gamson J; Mitchell J B
Nitric oxide protects against alkyl peroxide-mediated cytotoxicity: further insights into the role nitric oxide plays in oxidative stress.
Archives of biochemistry and biophysics 1995;319(2):402-7.
1994: Wink D A; Laval J
The Fpg protein, a DNA repair enzyme, is inhibited by the biomediator nitric oxide in vitro and in vivo.
Carcinogenesis 1994;15(10):2125-9.
1994: Routledge M N; Mirsky F J; Wink D A; Keefer L K; Dipple A
Nitrite-induced mutations in a forward mutation assay: influence of nitrite concentration and pH.
Mutation research 1994;322(4):341-6.
1994: Wink D A; Wink C B; Nims R W; Ford P C
Oxidizing intermediates generated in the Fenton reagent: kinetic arguments against the intermediacy of the hydroxyl radical.
Environmental health perspectives 1994;102 Suppl 3():11-5.
1994: Routledge M N; Wink D A; Keefer L K; Dipple A
DNA sequence changes induced by two nitric oxide donor drugs in the supF assay.
Chemical research in toxicology 1994;7(5):628-32.
1994: Wink D A; Nims R W; Saavedra J E; Utermahlen W E; Ford P C
The Fenton oxidation mechanism: reactivities of biologically relevant substrates with two oxidizing intermediates differ from those predicted for the hydroxyl radical.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6604-8.
1994: Wink D A; Nims R W; Darbyshire J F; Christodoulou D; Hanbauer I; Cox G W; Laval F; Laval J; Cook J A; Krishna M C
Reaction kinetics for nitrosation of cysteine and glutathione in aerobic nitric oxide solutions at neutral pH. Insights into the fate and physiological effects of intermediates generated in the NO/O2 reaction.
Chemical research in toxicology 1994;7(4):519-25.
1994: Liebmann J; DeLuca A M; Coffin D; Keefer L K; Venzon D; Wink D A; Mitchell J B
In vivo radiation protection by nitric oxide modulation.
Cancer research 1994;54(13):3365-8.
1993: Mitchell J B; Wink D A; DeGraff W; Gamson J; Keefer L K; Krishna M C
Hypoxic mammalian cell radiosensitization by nitric oxide.
Cancer research 1993;53(24):5845-8.
1993: Wink D A; Hanbauer I; Krishna M C; DeGraff W; Gamson J; Mitchell J B
Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):9813-7.
1993: Routledge M N; Wink D A; Keefer L K; Dipple A
Mutations induced by saturated aqueous nitric oxide in the pSP189 supF gene in human Ad293 and E. coli MBM7070 cells.
Carcinogenesis 1993;14(7):1251-4.
1993: Morley D; Maragos C M; Zhang X Y; Boignon M; Wink D A; Keefer L K
Mechanism of vascular relaxation induced by the nitric oxide (NO)/nucleophile complexes, a new class of NO-based vasodilators.
Journal of cardiovascular pharmacology 1993;21(4):670-6.
1993: Nims R W; Syi J L; Wink D A; Nelson V C; Thomas P E; Jones C R; Diwan B A; Keefer L K; Rice J M; Lubet R A
Hepatic cytochrome P450 2B-type induction by ethyl/phenyl-substituted congeners of phenobarbital in the rat.
Chemical research in toxicology 1993;6(2):180-7.
1993: Wink D A; Darbyshire J F; Nims R W; Saavedra J E; Ford P C
Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: determination of the kinetics for oxidation and nitrosation by intermediates generated in the NO/O2 reaction.
Chemical research in toxicology 1993;6(1):23-7.
1993: Wink D A; Osawa Y; Darbyshire J F; Jones C R; Eshenaur S C; Nims R W
Inhibition of cytochromes P450 by nitric oxide and a nitric oxide-releasing agent.
Archives of biochemistry and biophysics 1993;300(1):115-23.
1991: Maragos C M; Morley D; Wink D A; Dunams T M; Saavedra J E; Hoffman A; Bove A A; Isaac L; Hrabie J A; Keefer L K
Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects.
Journal of medicinal chemistry 1991;34(11):3242-7.
1991: Wink D A; Kasprzak K S; Maragos C M; Elespuru R K; Misra M; Dunams T M; Cebula T A; Koch W H; Andrews A W; Allen J S
DNA deaminating ability and genotoxicity of nitric oxide and its progenitors.
Science (New York, N.Y.) 1991;254(5034):1001-3.
1991: Wink D A; Nims R W; Desrosiers M F; Ford P C; Keefer L K
A kinetic investigation of intermediates formed during the Fenton reagent mediated degradation of N-nitrosodimethylamine: evidence for an oxidative pathway not involving hydroxyl radical.
Chemical research in toxicology 1991;4(5):510-2.

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