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Dale Bredesen

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Alzheimer Disease

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Publications

TOP 3
Zhang Junli; Gorostiza Olivia F; Tang Huidong; Bredesen Dale E; Galvan Veronica
Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience.
Park Sun Ah; Shaked Gideon M; Bredesen Dale E; Koo Edward H
Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein.
Mille F; Llambi F; Guix C; Delloye-Bourgeois C; Guenebeaud C; Castro-Obregon S; Bredesen D E; Thibert C; Mehlen P
Interfering with multimerization of netrin-1 receptors triggers tumor cell death.

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All Publications

2010: Zhang Junli; Gorostiza Olivia F; Tang Huidong; Bredesen Dale E; Galvan Veronica
Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience.
Behavioural brain research 2010;206(2):202-7.
2009: Park Sun Ah; Shaked Gideon M; Bredesen Dale E; Koo Edward H
Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein.
Biochemical and biophysical research communications 2009;388(2):450-5.
2009: Mille F; Llambi F; Guix C; Delloye-Bourgeois C; Guenebeaud C; Castro-Obregon S; Bredesen D E; Thibert C; Mehlen P
Interfering with multimerization of netrin-1 receptors triggers tumor cell death.
Cell death and differentiation 2009;16(10):1344-51.
2009: Chinta Shankar J; Poksay Karen S; Kaundinya Gaayatri; Hart Matthew; Bredesen Dale E; Andersen Julie K; Rao Rammohan V
Endoplasmic reticulum stress-induced cell death in dopaminergic cells: effect of resveratrol.
Journal of molecular neuroscience : MN 2009;39(1-2):157-68.
2009: Galluzzi L; Aaronson S A; Abrams J; Alnemri E S; Andrews D W; Baehrecke E H; Bazan N G; Blagosklonny M V; Blomgren K; Borner C; Bredesen D E; Brenner C; Castedo M; Cidlowski J A; Ciechanover A; Cohen G M; De Laurenzi V; De Maria R; Deshmukh M; Dynlacht B D; El-Deiry W S; Flavell R A; Fulda S; Garrido C; Golstein P; Gougeon M-L; Green D R; Gronemeyer H; Hajnóczky G; Hardwick J M; Hengartner M O; Ichijo H; Jäättelä M; Kepp O; Kimchi A; Klionsky D J; Knight R A; Kornbluth S; Kumar S; Levine B; Lipton S A; Lugli E; Madeo F; Malomi W; Marine J-C W; Martin S J; Medema J P; Mehlen P; Melino G; Moll U M; Morselli E; Nagata S; Nicholson D W; Nicotera P; Nuñez G; Oren M; Penninger J; Pervaiz S; Peter M E; Piacentini M; Prehn J H M; Puthalakath H; Rabinovich G A; Rizzuto R; Rodrigues C M P; Rubinsztein D C; Rudel T; Scorrano L; Simon H-U; Steller H; Tschopp J; Tsujimoto Y; Vandenabeele P; Vitale I; Vousden K H; Youle R J; Yuan J; Zhivotovsky B; Kroemer G
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.
Cell death and differentiation 2009;16(8):1093-107.
2009: Lourenço F C; Galvan V; Fombonne J; Corset V; Llambi F; Müller U; Bredesen D E; Mehlen P
Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production.
Cell death and differentiation 2009;16(5):655-63.
2009: Fombonne Joanna; Rabizadeh Shahrooz; Banwait Surita; Mehlen Patrick; Bredesen Dale E
Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction.
Annals of neurology 2009;65(3):294-303.
2009: Bredesen Dale E
Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence.
Molecular neurodegeneration 2009;4():27.
2008: Rossi D; Brambilla L; Valori C F; Roncoroni C; Crugnola A; Yokota T; Bredesen D E; Volterra A
Focal degeneration of astrocytes in amyotrophic lateral sclerosis.
Cell death and differentiation 2008;15(11):1691-700.
2008: Ellerby H Michael; Bredesen Dale E; Fujimura Satoshi; John Varghese
Hunter-killer peptide (HKP) for targeted therapy.
Journal of medicinal chemistry 2008;51(19):5887-92.
2008: Galvan Veronica; Zhang Junli; Gorostiza Olivia F; Banwait Surita; Huang Wei; Ataie Marina; Tang Huidong; Bredesen Dale E
Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664.
Behavioural brain research 2008;191(2):246-55.
2008: Bakhshi Jason; Weinstein Lee; Poksay Karen S; Nishinaga Brian; Bredesen Dale E; Rao Rammohan V
Coupling endoplasmic reticulum stress to the cell death program in mouse melanoma cells: effect of curcumin.
Apoptosis : an international journal on programmed cell death 2008;13(7):904-14.
2008: Bredesen Dale E
Programmed cell death mechanisms in neurological disease.
Current molecular medicine 2008;8(3):173-86.
2008: Banwait Surita; Galvan Veronica; Zhang Junli; Gorostiza Olivia F; Ataie Marina; Huang Wei; Crippen Danielle; Koo Edward H; Bredesen Dale E
C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2008;13(1):1-16.
2008: Klionsky Daniel J; Abeliovich Hagai; Agostinis Patrizia; Agrawal Devendra K; Aliev Gjumrakch; Askew David S; Baba Misuzu; Baehrecke Eric H; Bahr Ben A; Ballabio Andrea; Bamber Bruce A; Bassham Diane C; Bergamini Ettore; Bi Xiaoning; Biard-Piechaczyk Martine; Blum Janice S; Bredesen Dale E; Brodsky Jeffrey L; Brumell John H; Brunk Ulf T; Bursch Wilfried; Camougrand Nadine; Cebollero Eduardo; Cecconi Francesco; Chen Yingyu; Chin Lih-Shen; Choi Augustine; Chu Charleen T; Chung Jongkyeong; Clarke Peter G H; Clark Robert S B; Clarke Steven G; Clavé Corinne; Cleveland John L; Codogno Patrice; Colombo María I; Coto-Montes Ana; Cregg James M; Cuervo Ana Maria; Debnath Jayanta; Demarchi Francesca; Dennis Patrick B; Dennis Phillip A; Deretic Vojo; Devenish Rodney J; Di Sano Federica; Dice J Fred; Difiglia Marian; Dinesh-Kumar Savithramma; Distelhorst Clark W; Djavaheri-Mergny Mojgan; Dorsey Frank C; Dröge Wulf; Dron Michel; Dunn William A; Duszenko Michael; Eissa N Tony; Elazar Zvulun; Esclatine Audrey; Eskelinen Eeva-Liisa; Fésüs László; Finley Kim D; Fuentes José M; Fueyo Juan; Fujisaki Kozo; Galliot Brigitte; Gao Fen-Biao; Gewirtz David A; Gibson Spencer B; Gohla Antje; Goldberg Alfred L; Gonzalez Ramon; González-Estévez Cristina; Gorski Sharon; Gottlieb Roberta A; Häussinger Dieter; He You-Wen; Heidenreich Kim; Hill Joseph A; Høyer-Hansen Maria; Hu Xun; Huang Wei-Pang; Iwasaki Akiko; Jäättelä Marja; Jackson William T; Jiang Xuejun; Jin Shengkan; Johansen Terje; Jung Jae U; Kadowaki Motoni; Kang Chanhee; Kelekar Ameeta; Kessel David H; Kiel Jan A K W; Kim Hong Pyo; Kimchi Adi; Kinsella Timothy J; Kiselyov Kirill; Kitamoto Katsuhiko; Knecht Erwin; Komatsu Masaaki; Kominami Eiki; Kondo Seiji; Kovács Attila L; Kroemer Guido; Kuan Chia-Yi; Kumar Rakesh; Kundu Mondira; Landry Jacques; Laporte Marianne; Le Weidong; Lei Huan-Yao; Lenardo Michael J; Levine Beth; Lieberman Andrew; Lim Kah-Leong; Lin Fu-Cheng; Liou Willisa; Liu Leroy F; Lopez-Berestein Gabriel; López-Otín Carlos; Lu Bo; Macleod Kay F; Malorni Walter; Martinet Wim; Matsuoka Ken; Mautner Josef; Meijer Alfred J; Meléndez Alicia; Michels Paul; Miotto Giovanni; Mistiaen Wilhelm P; Mizushima Noboru; Mograbi Baharia; Monastyrska Iryna; Moore Michael N; Moreira Paula I; Moriyasu Yuji; Motyl Tomasz; Münz Christian; Murphy Leon O; Naqvi Naweed I; Neufeld Thomas P; Nishino Ichizo; Nixon Ralph A; Noda Takeshi; Nürnberg Bernd; Ogawa Michinaga; Oleinick Nancy L; Olsen Laura J; Ozpolat Bulent; Paglin Shoshana; Palmer Glen E; Papassideri Issidora; Parkes Miles; Perlmutter David H; Perry George; Piacentini Mauro; Pinkas-Kramarski Ronit; Prescott Mark; Proikas-Cezanne Tassula; Raben Nina; Rami Abdelhaq; Reggiori Fulvio; Rohrer Bärbel; Rubinsztein David C; Ryan Kevin M; Sadoshima Junichi; Sakagami Hiroshi; Sakai Yasuyoshi; Sandri Marco; Sasakawa Chihiro; Sass Miklós; Schneider Claudio; Seglen Per O; Seleverstov Oleksandr; Settleman Jeffrey; Shacka John J; Shapiro Irving M; Sibirny Andrei; Silva-Zacarin Elaine C M; Simon Hans-Uwe; Simone Cristiano; Simonsen Anne; Smith Mark A; Spanel-Borowski Katharina; Srinivas Vickram; Steeves Meredith; Stenmark Harald; Stromhaug Per E; Subauste Carlos S; Sugimoto Seiichiro; Sulzer David; Suzuki Toshihiko; Swanson Michele S; Tabas Ira; Takeshita Fumihiko; Talbot Nicholas J; Tallóczy Zsolt; Tanaka Keiji; Tanaka Kozo; Tanida Isei; Taylor Graham S; Taylor J Paul; Terman Alexei; Tettamanti Gianluca; Thompson Craig B; Thumm Michael; Tolkovsky Aviva M; Tooze Sharon A; Truant Ray; Tumanovska Lesya V; Uchiyama Yasuo; Ueno Takashi; Uzcátegui Néstor L; van der Klei Ida; Vaquero Eva C; Vellai Tibor; Vogel Michael W; Wang Hong-Gang; Webster Paul; Wiley John W; Xi Zhijun; Xiao Gutian; Yahalom Joachim; Yang Jin-Ming; Yap George; Yin Xiao-Ming; Yoshimori Tamotsu; Yu Li; Yue Zhenyu; Yuzaki Michisuke; Zabirnyk Olga; Zheng Xiaoxiang; Zhu Xiongwei; Deter Russell L
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.
Autophagy 2008;4(2):151-75.
2008: Nguyen Thuy-Vi V; Galvan Veronica; Huang Wei; Banwait Surita; Tang Huidong; Zhang Junli; Bredesen Dale E
Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.
Journal of neurochemistry 2008;104(4):1065-80.
2008: Chinta Shankar J; Rane Anand; Poksay Karen S; Bredesen Dale E; Andersen Julie K; Rao Rammohan V
Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat.
Neuromolecular medicine 2008;10(4):333-42.
2007: Bredesen Dale E; Rabizadeh Shahrooz
APP-based neuroprotective strategies.
Current Alzheimer research 2007;4(5):541-3.
2007: Levy Robert M; Bredesen Dale E; Rosenblum Mark L
Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature. 1985.
Journal of neurosurgery 2007;107(6):1253-73; discussion 1251.
2007: Galvan Veronica; Bredesen Dale E
Neurogenesis in the adult brain: implications for Alzheimer's disease.
CNS & neurological disorders drug targets 2007;6(5):303-10.
2007: Galvan Veronica; Banwait Surita; Spilman Patricia; Gorostiza Olivia F; Peel Alyson; Ataie Marina; Crippen Danielle; Huang Wei; Sidhu Gurleen; Ichijo Hidenori; Bredesen Dale E
Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex.
Neurobiology of disease 2007;28(1):65-75.
2007: Young Jessica E; Gouw Launce; Propp Stephanie; Sopher Bryce L; Taylor Jillian; Lin Amy; Hermel Evan; Logvinova Anna; Chen Sylvia F; Chen Shiming; Bredesen Dale E; Truant Ray; Ptacek Louis J; La Spada Albert R; Ellerby Lisa M
Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.
The Journal of biological chemistry 2007;282(41):30150-60.
2007: Madden David T; Egger Lotti; Bredesen Dale E
A calpain-like protease inhibits autophagic cell death.
Autophagy 2007;3(5):519-22.
2007: Egger L; Madden D T; Rhême C; Rao R V; Bredesen D E
Endoplasmic reticulum stress-induced cell death mediated by the proteasome.
Cell death and differentiation 2007;14(6):1172-80.
2007: Bredesen Dale E
Key note lecture: toward a mechanistic taxonomy for cell death programs.
Stroke; a journal of cerebral circulation 2007;38(2 Suppl):652-60.
2007: Kurakin Alexei; Bredesen Dale E
An unconventional IAP-binding motif revealed by target-assisted iterative screening (TAIS) of the BIR3-cIAP1 domain.
Journal of molecular recognition : JMR 2007;20(1):39-50.
2007: Stoka Veronika; Turk Vito; Bredesen Dale E
Differential regulation of Smac/DIABLO and Hsp-70 during brain maturation.
Neuromolecular medicine 2007;9(3):255-63.
2007: Kurakin Alexei; Swistowski Andrzej; Wu Susan C; Bredesen Dale E
The PDZ domain as a complex adaptive system.
PloS one 2007;2(9):e953.
2007: del Rio Gabriel; Kane Darci J; Ball Keith D; Bredesen Dale E
A novel motif identified in dependence receptors.
PloS one 2007;2(5):e463.
2007: Cusack Michael P; Thibert Boris; Bredesen Dale E; Del Rio Gabriel
Efficient identification of critical residues based only on protein structure by network analysis.
PloS one 2007;2(5):e421.
2006: Saganich Michael J; Schroeder Brock E; Galvan Veronica; Bredesen Dale E; Koo Edward H; Heinemann Stephen F
Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(52):13428-36.
2006: Bredesen Dale E; Rao Rammohan V; Mehlen Patrick
Cell death in the nervous system.
Nature 2006;443(7113):796-802.
2006: Stoka Veronika; Turk Vito; Bredesen Dale E
Differential regulation of the intrinsic pathway of apoptosis in brain and liver during ageing.
FEBS letters 2006;580(15):3739-45.
2006: Shaked G M; Kummer M P; Lu D C; Galvan V; Bredesen D E; Koo E H
Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624).
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(8):1254-6.
2006: Galvan Veronica; Gorostiza Olivia F; Banwait Surita; Ataie Marina; Logvinova Anna V; Sitaraman Sandhya; Carlson Elaine; Sagi Sarah A; Chevallier Nathalie; Jin Kunlin; Greenberg David A; Bredesen Dale E
Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):7130-5.
2006: Rao R V; Niazi K; Mollahan P; Mao X; Crippen D; Poksay K S; Chen S; Bredesen D E
Coupling endoplasmic reticulum stress to the cell-death program: a novel HSP90-independent role for the small chaperone protein p23.
Cell death and differentiation 2006;13(3):415-25.
2005: Warner Huber; Anderson Julie; Austad Steven; Bergamini Ettore; Bredesen Dale; Butler Robert; Carnes Bruce A; Clark Brian F C; Cristofalo Vincent; Faulkner John; Guarente Leonard; Harrison David E; Kirkwood Tom; Lithgow Gordon; Martin George; Masoro Ed; Melov Simon; Miller Richard A; Olshansky S Jay; Partridge Linda; Pereira-Smith Olivia; Perls Tom; Richardson Arlan; Smith James; von Zglinicki Thomas; Wang Eugenia; Wei Jeanne Y; Williams T Franklin
Science fact and the SENS agenda. What can we reasonably expect from ageing research?
EMBO reports 2005;6(11):1006-8.
2005: Stoka Veronika; Chen Sylvia F; Turk Vito; Bredesen Dale E
Developmental shift in the apostat: comparison of neurones and astrocytes.
FEBS letters 2005;579(27):6147-50.
2005: Cottrell Barbara A; Galvan Veronica; Banwait Surita; Gorostiza Olivia; Lombardo Christian R; Williams Tristan; Schilling Birgit; Peel Alyson; Gibson Bradford; Koo Edward H; Link Christopher D; Bredesen Dale E
A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease.
Annals of neurology 2005;58(2):277-89.
2005: Bredesen D E; Mehlen P; Rabizadeh S
Receptors that mediate cellular dependence.
Cell death and differentiation 2005;12(8):1031-43.
2005: Thibert Boris; Bredesen Dale E; del Rio Gabriel
Improved prediction of critical residues for protein function based on network and phylogenetic analyses.
BMC bioinformatics 2005;6():213.
2004: Bredesen Dale E
Toward a mechanistic taxonomy of cell death programs.
Journal of Alzheimer's disease : JAD 2004;6(6 Suppl):S3-6.
2004: Rao Rammohan V; Bredesen Dale E
Misfolded proteins, endoplasmic reticulum stress and neurodegeneration.
Current opinion in cell biology 2004;16(6):653-62.
2004: Bredesen Dale E
Rebuttal to Austad: 'Is aging programmed?
Aging cell 2004;3(5):261-2.
2004: Bredesen Dale E
The non-existent aging program: how does it work?
Aging cell 2004;3(5):255-9.
2004: Sperandio S; Poksay K; de Belle I; Lafuente M J; Liu B; Nasir J; Bredesen D E
Paraptosis: mediation by MAP kinases and inhibition by AIP-1/Alix.
Cell death and differentiation 2004;11(10):1066-75.
2004: Mazelin Laetitia; Bernet Agnès; Bonod-Bidaud Christelle; Pays Laurent; Arnaud Ségolène; Gespach Christian; Bredesen Dale E; Scoazec Jean-Yves; Mehlen Patrick
Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.
Nature 2004;431(7004):80-4.
2004: Jin Kunlin; Galvan Veronica; Xie Lin; Mao Xiao Ou; Gorostiza Olivia F; Bredesen Dale E; Greenberg David A
Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13363-7.
2004: Hashimoto Yuichi; Kaneko Yuka; Tsukamoto Emi; Frankowski Harald; Kouyama Keisuke; Kita Yoshiko; Niikura Takako; Aiso Sadakazu; Bredesen Dale E; Matsuoka Masaaki; Nishimoto Ikuo
Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid-beta peptides via p75NTR/PLAIDD.
Journal of neurochemistry 2004;90(3):549-58.
2004: Bredesen Dale E; Mehlen Patrick; Rabizadeh Shahrooz
Apoptosis and dependence receptors: a molecular basis for cellular addiction.
Physiological reviews 2004;84(2):411-30.
2004: Castro-Obregón Susana; Rao Rammohan V; del Rio Gabriel; Chen Sylvia F; Poksay Karen S; Rabizadeh Shahrooz; Vesce Sabino; Zhang Xiao-Khun; Swanson Raymond A; Bredesen Dale E
Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77.
The Journal of biological chemistry 2004;279(17):17543-53.
2004: Rao R V; Ellerby H M; Bredesen D E
Coupling endoplasmic reticulum stress to the cell death program.
Cell death and differentiation 2004;11(4):372-80.
2004: Hermel E; Gafni J; Propp S S; Leavitt B R; Wellington C L; Young J E; Hackam A S; Logvinova A V; Peel A L; Chen S F; Hook V; Singaraja R; Krajewski S; Goldsmith P C; Ellerby H M; Hayden M R; Bredesen D E; Ellerby L M
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.
Cell death and differentiation 2004;11(4):424-38.
2004: Galvan V; Kurakin A V; Bredesen D E
Interaction of checkpoint kinase 1 and the X-linked inhibitor of apoptosis during mitosis.
FEBS letters 2004;558(1-3):57-62.
2004: Mehlen P; Bredesen D E
The dependence receptor hypothesis.
Apoptosis : an international journal on programmed cell death 2004;9(1):37-49.
2004: Yokota Takanori; Miyagishi Makoto; Hino Taro; Matsumura Ryusuke; Tasinato Andrea; Urushitani Makoto; Rao Rammohan V; Takahashi Ryosuke; Bredesen Dale E; Taira Kazunari; Mizusawa Hidehiro;
siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme.
Biochemical and biophysical research communications 2004;314(1):283-91.
2004: Rao Rammohan V; Poksay Karen S; Castro-Obregon Susana; Schilling Birgit; Row Richard H; del Rio Gabriel; Gibson Bradford W; Ellerby H Michael; Bredesen Dale E
Molecular components of a cell death pathway activated by endoplasmic reticulum stress.
The Journal of biological chemistry 2004;279(1):177-87.
2004: Peel Alyson L; Sorscher Noah; Kim Joseph Y; Galvan Veronica; Chen Sylvia; Bredesen Dale E
Tau phosphorylation in Alzheimer's disease: potential involvement of an APP-MAP kinase complex.
Neuromolecular medicine 2004;5(3):205-18.
2004: Kurakin Alexei; Wu Susan; Bredesen Dale E
Target-assisted iterative screening of phage surface display cDNA libraries.
Methods in molecular biology (Clifton, N.J.) 2004;264():47-60.
2003: Lu Daniel C; Shaked Gideon M; Masliah Eliezer; Bredesen Dale E; Koo Edward H
Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes.
Annals of neurology 2003;54(6):781-9.
2003: Mehlen Patrick; Bredesen Dale E
Meeting report: cellular dependence--old concept, new mechanisms.
Science's STKE : signal transduction knowledge environment 2003;2003(213):pe55.
2003: Lu Daniel C; Soriano Salvador; Bredesen Dale E; Koo Edward H
Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity.
Journal of neurochemistry 2003;87(3):733-41.
2003: Peel Alyson L; Bredesen Dale E
Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice.
Neurobiology of disease 2003;14(1):52-62.
2003: Kurakin Alexei V; Wu Susan; Bredesen Dale E
Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening.
The Journal of biological chemistry 2003;278(36):34102-9.
2003: Ellerby H Michael; Lee Sannamu; Ellerby Lisa M; Chen Sylvia; Kiyota Taira; del Rio Gabriel; Sugihara Gohsuke; Sun Yan; Bredesen Dale E; Arap Wadih; Pasqualini Renata
An artificially designed pore-forming protein with anti-tumor effects.
The Journal of biological chemistry 2003;278(37):35311-6.
2003: Rabizadeh Shahrooz; Bredesen Dale E
Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).
Cytokine & growth factor reviews 2003;14(3-4):225-39.
2003: Galvan Veronica; Logvinova Anna; Sperandio Sabina; Ichijo Hidenori; Bredesen Dale E
Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1).
The Journal of biological chemistry 2003;278(15):13325-32.
2002: Wellington Cheryl L; Ellerby Lisa M; Gutekunst Claire-Anne; Rogers Danny; Warby Simon; Graham Rona K; Loubser Odell; van Raamsdonk Jeremy; Singaraja Roshni; Yang Yu-Zhou; Gafni Juliette; Bredesen Dale; Hersch Steven M; Leavitt Blair R; Roy Sophie; Nicholson Donald W; Hayden Michael R
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(18):7862-72.
2002: Castro-Obregón S; Del Rio G; Chen S F; Swanson R A; Frankowski H; Rao R V; Stoka V; Vesce S; Nicholls D G; Bredesen D E
A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death.
Cell death and differentiation 2002;9(8):807-17.
2002: Galvan Veronica; Chen Sylvia; Lu Daniel; Logvinova Anna; Goldsmith Paul; Koo Edward H; Bredesen Dale E
Caspase cleavage of members of the amyloid precursor family of proteins.
Journal of neurochemistry 2002;82(2):283-94.
2002: Kurakin Alexei; Bredesen Dale
Target-assisted iterative screening reveals novel interactors for PSD95, Nedd4, Src, Abl and Crk proteins.
Journal of biomolecular structure & dynamics 2002;19(6):1015-29.
2002: Rao Rammohan V; Castro-Obregon Susana; Frankowski Harald; Schuler Martin; Stoka Veronica; del Rio Gabriel; Bredesen Dale E; Ellerby H Michael
Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway.
The Journal of biological chemistry 2002;277(24):21836-42.
2002: Rao Rammohan V; Peel Alyson; Logvinova Anna; del Rio Gabriel; Hermel Evan; Yokota Takanori; Goldsmith Paul C; Ellerby Lisa M; Ellerby H Michael; Bredesen Dale E
Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78.
FEBS letters 2002;514(2-3):122-8.
2002: Arap Wadih; Haedicke Wolfgang; Bernasconi Michele; Kain Renate; Rajotte Daniel; Krajewski Stanislaw; Ellerby H Michael; Bredesen Dale E; Pasqualini Renata; Ruoslahti Erkki
Targeting the prostate for destruction through a vascular address.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1527-31.
2002: Frankowski Harald; Castro-Obregon Susana; del Rio Gabriel; Rao Rammohan V; Bredesen Dale E
PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor.
Neuromolecular medicine 2002;1(3):153-70.
2001: Ethell D W; Bossy-Wetzel E; Bredesen D E
Caspase 7 can cleave tumor necrosis factor receptor-I (p60) at a non-consensus motif, in vitro.
Biochimica et biophysica acta 2001;1541(3):231-8.
2001: Lee M; Hyun D H; Marshall K A; Ellerby L M; Bredesen D E; Jenner P; Halliwell B
Effect of overexpression of BCL-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome.
Free radical biology & medicine 2001;31(12):1550-9.
2001: del Rio G; Bartley T F; del-Rio H; Rao R; Jin K L; Greenberg D A; Eshoo M; Bredesen D E
Mining DNA microarray data using a novel approach based on graph theory.
FEBS letters 2001;509(2):230-4.
2001: Lee S; Furuya T; Kiyota T; Takami N; Murata K; Niidome Y; Bredesen D E; Ellerby H M; Sugihara G
De novo-designed peptide transforms Golgi-specific lipids into Golgi-like nanotubules.
The Journal of biological chemistry 2001;276(44):41224-8.
2001: Bredesen D E
Neurodegenerative disease and cancer: two sides of a coin?
Hospital practice (1995) 2001;36(9):39-42, 45.
2001: Rao R V; Hermel E; Castro-Obregon S; del Rio G; Ellerby L M; Ellerby H M; Bredesen D E
Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation.
The Journal of biological chemistry 2001;276(36):33869-74.
2001: Zhong L T; Manzi A; Skowronski E; Notterpek L; Fluharty A L; Faull K F; Masada I; Rabizadeh S; Varsanyi-Nagy M; Ruan Y; Oh J D; Butcher L L; Bredesen D E
A monoclonal antibody that induces neuronal apoptosis binds a metastasis marker.
Cancer research 2001;61(15):5741-8.
2001: Peel A L; Rao R V; Cottrell B A; Hayden M R; Ellerby L M; Bredesen D E
Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue.
Human molecular genetics 2001;10(15):1531-8.
2001: del Rio G; Castro-Obregon S; Rao R; Ellerby H M; Bredesen D E
APAP, a sequence-pattern recognition approach identifies substance P as a potential apoptotic peptide.
FEBS letters 2001;494(3):213-9.
2001: Forcet C; Ye X; Granger L; Corset V; Shin H; Bredesen D E; Mehlen P
The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3416-21.
2001: Stoka V; Turk B; Schendel S L; Kim T H; Cirman T; Snipas S J; Ellerby L M; Bredesen D; Freeze H; Abrahamson M; Bromme D; Krajewski S; Reed J C; Yin X M; Turk V; Salvesen G S
Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route.
The Journal of biological chemistry 2001;276(5):3149-57.
2001: Gerlag D M; Borges E; Tak P P; Ellerby H M; Bredesen D E; Pasqualini R; Ruoslahti E; Firestein G S
Suppression of murine collagen-induced arthritis by targeted apoptosis of synovial neovasculature.
Arthritis research 2001;3(6):357-61.
2000: Rabizadeh S; Ye X; Sperandio S; Wang J J; Ellerby H M; Ellerby L M; Giza C; Andrusiak R L; Frankowski H; Yaron Y; Moayeri N N; Rovelli G; Evans C J; Butcher L L; Nolan G P; Assa-Munt N; Bredesen D E
Neurotrophin dependence domain: a domain required for the mediation of apoptosis by the p75 neurotrophin receptor.
Journal of molecular neuroscience : MN 2000;15(3):215-29.
2000: Sperandio S; de Belle I; Bredesen D E
An alternative, nonapoptotic form of programmed cell death.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14376-81.
2000: Cafe C; Testa M P; Sheldon P J; French W P; Ellerby L M; Bredesen D E
Loss of oxidation-reduction specificity in amyotrophic lateral sclerosis-associated CuZnSOD mutants.
Journal of molecular neuroscience : MN 2000;15(2):71-83.
2000: Bredesen D E
Apoptosis: overview and signal transduction pathways.
Journal of neurotrauma 2000;17(10):801-10.
2000: Wang J J; Tasinato A; Ethell D W; Testa M P; Bredesen D E
Phosphorylation of the common neurotrophin receptor p75 by p38beta2 kinase affects NF-kappaB and AP-1 activities.
Journal of molecular neuroscience : MN 2000;15(1):19-29.
2000: Bordeaux M C; Forcet C; Granger L; Corset V; Bidaud C; Billaud M; Bredesen D E; Edery P; Mehlen P
The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease.
The EMBO journal 2000;19(15):4056-63.
2000: Mehlen P; Bredesen D E
[Dependence receptors: links between apoptosis, nervous system development and control of tumorigenesis]
Bulletin du cancer 2000;87(7-8):537-41.
2000: Wei H; Leeds P; Chen R W; Wei W; Leng Y; Bredesen D E; Chuang D M
Neuronal apoptosis induced by pharmacological concentrations of 3-hydroxykynurenine: characterization and protection by dantrolene and Bcl-2 overexpression.
Journal of neurochemistry 2000;75(1):81-90.
2000: Wang J J; Rabizadeh S; Tasinato A; Sperandio S; Ye X; Green M; Assa-Munt N; Spencer D; Bredesen D E
Dimerization-dependent block of the proapoptotic effect of p75(NTR).
Journal of neuroscience research 2000;60(5):587-93.
2000: Wellington C L; Singaraja R; Ellerby L; Savill J; Roy S; Leavitt B; Cattaneo E; Hackam A; Sharp A; Thornberry N; Nicholson D W; Bredesen D E; Hayden M R
Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells.
The Journal of biological chemistry 2000;275(26):19831-8.
2000: Kluck R M; Ellerby L M; Ellerby H M; Naiem S; Yaffe M P; Margoliash E; Bredesen D; Mauk A G; Sherman F; Newmeyer D D
Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation.
The Journal of biological chemistry 2000;275(21):16127-33.
2000: Lu D C; Rabizadeh S; Chandra S; Shayya R F; Ellerby L M; Ye X; Salvesen G S; Koo E H; Bredesen D E
A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor.
Nature medicine 2000;6(4):397-404.
2000: Kelner G S; Lee M; Clark M E; Maciejewski D; McGrath D; Rabizadeh S; Lyons T; Bredesen D; Jenner P; Maki R A
The copper transport protein Atox1 promotes neuronal survival.
The Journal of biological chemistry 2000;275(1):580-4.
2000: Ellerby L M; Bredesen D E
Measurement of cellular oxidation, reactive oxygen species, and antioxidant enzymes during apoptosis.
Methods in enzymology 2000;322():413-21.
1999: Rabizadeh S; Rabizadeh S; Ye X; Wang J J; Bredesen D E
Neurotrophin dependence mediated by p75NTR: contrast between rescue by BDNF and NGF.
Cell death and differentiation 1999;6(12):1222-7.
1999: Irie S; Hachiya T; Rabizadeh S; Maruyama W; Mukai J; Li Y; Reed J C; Bredesen D E; Sato T A
Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation.
FEBS letters 1999;460(2):191-8.
1999: Ye X; Mehlen P; Rabizadeh S; VanArsdale T; Zhang H; Shin H; Wang J J; Leo E; Zapata J; Hauser C A; Reed J C; Bredesen D E
TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.
The Journal of biological chemistry 1999;274(42):30202-8.
1999: Ellerby H M; Arap W; Ellerby L M; Kain R; Andrusiak R; Rio G D; Krajewski S; Lombardo C R; Rao R; Ruoslahti E; Bredesen D E; Pasqualini R
Anti-cancer activity of targeted pro-apoptotic peptides.
Nature medicine 1999;5(9):1032-8.
1999: Krajewski S; Krajewska M; Ellerby L M; Welsh K; Xie Z; Deveraux Q L; Salvesen G S; Bredesen D E; Rosenthal R E; Fiskum G; Reed J C
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5752-7.
1999: Ellerby L M; Andrusiak R L; Wellington C L; Hackam A S; Propp S S; Wood J D; Sharp A H; Margolis R L; Ross C A; Salvesen G S; Hayden M R; Bredesen D E
Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.
The Journal of biological chemistry 1999;274(13):8730-6.
1999: Ellerby L M; Hackam A S; Propp S S; Ellerby H M; Rabizadeh S; Cashman N R; Trifiro M A; Pinsky L; Wellington C L; Salvesen G S; Hayden M R; Bredesen D E
Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity.
Journal of neurochemistry 1999;72(1):185-95.
1999: Hong C S; Caromile L; Nomata Y; Mori H; Bredesen D E; Koo E H
Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(2):637-43.
1998: Mehlen P; Rabizadeh S; Snipas S J; Assa-Munt N; Salvesen G S; Bredesen D E
The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis.
Nature 1998;395(6704):801-4.
1998: Stennicke H R; Jürgensmeier J M; Shin H; Deveraux Q; Wolf B B; Yang X; Zhou Q; Ellerby H M; Ellerby L M; Bredesen D; Green D R; Reed J C; Froelich C J; Salvesen G S
Pro-caspase-3 is a major physiologic target of caspase-8.
The Journal of biological chemistry 1998;273(42):27084-90.
1998: Spear N; Estévez A G; Johnson G V; Bredesen D E; Thompson J A; Beckman J S
Enhancement of peroxynitrite-induced apoptosis in PC12 cells by fibroblast growth factor-1 and nerve growth factor requires p21Ras activation and is suppressed by Bcl-2.
Archives of biochemistry and biophysics 1998;356(1):41-5.
1998: Wei H; Wei W; Bredesen D E; Perry D C
Bcl-2 protects against apoptosis in neuronal cell line caused by thapsigargin-induced depletion of intracellular calcium stores.
Journal of neurochemistry 1998;70(6):2305-14.
1998: Bredesen D E; Ye X; Tasinato A; Sperandio S; Wang J J; Assa-Munt N; Rabizadeh S
p75NTR and the concept of cellular dependence: seeing how the other half die.
Cell death and differentiation 1998;5(5):365-71.
1998: Jürgensmeier J M; Xie Z; Deveraux Q; Ellerby L; Bredesen D; Reed J C
Bax directly induces release of cytochrome c from isolated mitochondria.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):4997-5002.
1998: Wellington C L; Ellerby L M; Hackam A S; Margolis R L; Trifiro M A; Singaraja R; McCutcheon K; Salvesen G S; Propp S S; Bromm M; Rowland K J; Zhang T; Rasper D; Roy S; Thornberry N; Pinsky L; Kakizuka A; Ross C A; Nicholson D W; Bredesen D E; Hayden M R
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
The Journal of biological chemistry 1998;273(15):9158-67.
1998: Martindale D; Hackam A; Wieczorek A; Ellerby L; Wellington C; McCutcheon K; Singaraja R; Kazemi-Esfarjani P; Devon R; Kim S U; Bredesen D E; Tufaro F; Hayden M R
Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates.
Nature genetics 1998;18(2):150-4.
1998: Bruce-Keller A J; Begley J G; Fu W; Butterfield D A; Bredesen D E; Hutchins J B; Hensley K; Mattson M P
Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta-peptide.
Journal of neurochemistry 1998;70(1):31-9.
1997: Ruan Y; Rabizadeh S; Camerini D; Bredesen D E
Expression of CD40 induces neural apoptosis.
Journal of neuroscience research 1997;50(3):383-90.
1997: Yeo T T; Chua-Couzens J; Butcher L L; Bredesen D E; Cooper J D; Valletta J S; Mobley W C; Longo F M
Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(20):7594-605.
1997: Hileman M R; Chapman B S; Rabizadeh S; Krishnan V V; Bredesen D; Assa-Munt N; Plesniak L A
A cytoplasmic peptide of the neurotrophin receptor p75NTR: induction of apoptosis and NMR determined helical conformation.
FEBS letters 1997;415(2):145-54.
1997: Bredesen D E; Ellerby L M; Hart P J; Wiedau-Pazos M; Valentine J S
Do posttranslational modifications of CuZnSOD lead to sporadic amyotrophic lateral sclerosis?
Annals of neurology 1997;42(2):135-7.
1997: Ellerby H M; Martin S J; Ellerby L M; Naiem S S; Rabizadeh S; Salvesen G S; Casiano C A; Cashman N R; Green D R; Bredesen D E
Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(16):6165-78.
1997: Bredesen D E; Rabizadeh S
p75NTR and apoptosis: Trk-dependent and Trk-independent effects.
Trends in neurosciences 1997;20(7):287-90.
1997: Kruman I; Bruce-Keller A J; Bredesen D; Waeg G; Mattson M P
Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(13):5089-100.
1997: Longo V D; Ellerby L M; Bredesen D E; Valentine J S; Gralla E B
Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast.
The Journal of cell biology 1997;137(7):1581-8.
1997: Keane R W; Srinivasan A; Foster L M; Testa M P; Ord T; Nonner D; Wang H G; Reed J C; Bredesen D E; Kayalar C
Activation of CPP32 during apoptosis of neurons and astrocytes.
Journal of neuroscience research 1997;48(2):168-80.
1996: Lyons T J; Liu H; Goto J J; Nersissian A; Roe J A; Graden J A; Café C; Ellerby L M; Bredesen D E; Gralla E B; Valentine J S
Mutations in copper-zinc superoxide dismutase that cause amyotrophic lateral sclerosis alter the zinc binding site and the redox behavior of the protein.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12240-4.
1996: Bredesen D E; Wiedau-Pazos M; Goto J J; Rabizadeh S; Roe J A; Gralla E B; Ellerby L M; Valentine J S
Cell death mechanisms in ALS.
Neurology 1996;47(4 Suppl 2):S36-8; discussion S38-9.
1996: Srinivasan A; Foster L M; Testa M P; Ord T; Keane R W; Bredesen D E; Kayalar C
Bcl-2 expression in neural cells blocks activation of ICE/CED-3 family proteases during apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(18):5654-60.
1996: Murphy A N; Bredesen D E; Cortopassi G; Wang E; Fiskum G
Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9893-8.
1996: Ellerby L M; Ellerby H M; Park S M; Holleran A L; Murphy A N; Fiskum G; Kane D J; Testa M P; Kayalar C; Bredesen D E
Shift of the cellular oxidation-reduction potential in neural cells expressing Bcl-2.
Journal of neurochemistry 1996;67(3):1259-67.
1996: Wiedau-Pazos M; Trudell J R; Altenbach C; Kane D J; Hubbell W L; Bredesen D E
Expression of bcl-2 inhibits cellular radical generation.
Free radical research 1996;24(3):205-12.
1996: Kayalar C; Ord T; Testa M P; Zhong L T; Bredesen D E
Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(5):2234-8.
1996: Wiedau-Pazos M; Goto J J; Rabizadeh S; Gralla E B; Roe J A; Lee M K; Valentine J S; Bredesen D E
Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis.
Science (New York, N.Y.) 1996;271(5248):515-8.
1996: Bredesen D E
Genetic control of neural cell apoptosis.
Perspectives on developmental neurobiology 1996;3(2):101-9.
1996: Sarafian T A; Bredesen D E; Verity M A
Cellular resistance to methylmercury.
Neurotoxicology 1996;17(1):27-36.
1995: Bredesen D E
Neural apoptosis.
Annals of neurology 1995;38(6):839-51.
1995: Myers K M; Fiskum G; Liu Y; Simmens S J; Bredesen D E; Murphy A N
Bcl-2 protects neural cells from cyanide/aglycemia-induced lipid oxidation, mitochondrial injury, and loss of viability.
Journal of neurochemistry 1995;65(6):2432-40.
1995: Verity M A; Bredesen D E; Sarafian T
Role of reactive oxygen species (ROS) in neuronal degeneration. Modulation by protooncogene expression.
Annals of the New York Academy of Sciences 1995;765():340.
1995: Hisanaga K; Kure S; Bredesen D E; Ikeda Y; Kohsaka S; Sharp F R
Apoptotic cell death of a temperature-sensitive central neuronal cell line.
Brain research 1995;684(1):79-86.
1995: Rabizadeh S; Gralla E B; Borchelt D R; Gwinn R; Valentine J S; Sisodia S; Wong P; Lee M; Hahn H; Bredesen D E
Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):3024-8.
1995: Kane D J; Ord T; Anton R; Bredesen D E
Expression of bcl-2 inhibits necrotic neural cell death.
Journal of neuroscience research 1995;40(2):269-75.
1995: Anton R; Kordower J H; Kane D J; Markham C H; Bredesen D E
Neural transplantation of cells expressing the anti-apoptotic gene bcl-2.
Cell transplantation 1995;4(1):49-54.
1994: Sarafian T A; Vartavarian L; Kane D J; Bredesen D E; Verity M A
bcl-2 expression decreases methyl mercury-induced free-radical generation and cell killing in a neural cell line.
Toxicology letters 1994;74(2):149-55.
1994: Rabizadeh S; Bitler C M; Butcher L L; Bredesen D E
Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(22):10703-6.
1994: Sarafian T A; Bredesen D E
Is apoptosis mediated by reactive oxygen species?
Free radical research 1994;21(1):1-8.
1994: Rabizadeh S; Bredesen D E
Is p75NGFR involved in developmental neural cell death?
Developmental neuroscience 1994;16(3-4):207-11.
1993: Rabizadeh S; LaCount D J; Friesen P D; Bredesen D E
Expression of the baculovirus p35 gene inhibits mammalian neural cell death.
Journal of neurochemistry 1993;61(6):2318-21.
1993: Kane D J; Sarafian T A; Anton R; Hahn H; Gralla E B; Valentine J S; Ord T; Bredesen D E
Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species.
Science (New York, N.Y.) 1993;262(5137):1274-7.
1993: Garcia P A; Bredesen D E; Vinters H V; Graefin von Einsiedel R; Williams R L; Kahn J O; Byers V S; Levin A S; Waites L A; Messing R O
Neurological reactions in HIV-infected patients treated with trichosanthin.
Neuropathology and applied neurobiology 1993;19(5):402-5.
1993: Zhong L T; Kane D J; Bredesen D E
BCL-2 blocks glutamate toxicity in neural cell lines.
Brain research. Molecular brain research 1993;19(4):353-5.
1993: Rabizadeh S; Oh J; Zhong L T; Yang J; Bitler C M; Butcher L L; Bredesen D E
Induction of apoptosis by the low-affinity NGF receptor.
Science (New York, N.Y.) 1993;261(5119):345-8.
1993: Zhong L T; Sarafian T; Kane D J; Charles A C; Mah S P; Edwards R H; Bredesen D E
bcl-2 inhibits death of central neural cells induced by multiple agents.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4533-7.
1993: Mah S P; Zhong L T; Liu Y; Roghani A; Edwards R H; Bredesen D E
The protooncogene bcl-2 inhibits apoptosis in PC12 cells.
Journal of neurochemistry 1993;60(3):1183-6.
1993: Verity A N; Bredesen D; Vonderscher C; Handley V W; Campagnoni A T
Expression of myelin protein genes and other myelin components in an oligodendrocytic cell line conditionally immortalized with a temperature-sensitive retrovirus.
Journal of neurochemistry 1993;60(2):577-87.
1993: Foster L M; Phan T; Verity A N; Bredesen D; Campagnoni A T
Generation and analysis of normal and shiverer temperature-sensitive immortalized cell lines exhibiting phenotypic characteristics of oligodendrocytes at several stages of differentiation.
Developmental neuroscience 1993;15(2):100-9.
1992: Yang J; Seelig M; Rayner S; Bredesen D E
Increasing the proliferative capacity of muscular dystrophy myoblasts.
Muscle & nerve 1992;15(8):941-8.
1992: Bredesen D E; Kane D J; Holtzman D M; Epstein C J
Preliminary characterization of long-term reaggregating cultures of trisomy 16 central nervous system.
Progress in clinical and biological research 1992;379():259-70.
1990: Kahn J O; Kaplan L D; Gambertoglio J G; Bredesen D; Arri C J; Turin L; Kibort T; Williams R L; Lifson J D; Volberding P A
The safety and pharmacokinetics of GLQ223 in subjects with AIDS and AIDS-related complex: a phase I study.
AIDS (London, England) 1990;4(12):1197-204.
1990: Bredesen D E; Hisanaga K; Sharp F R
Neural transplantation using temperature-sensitive immortalized neural cells: a preliminary report.
Annals of neurology 1990;27(2):205-7.
1990: Levy R M; Bredesen D E; Rosenblum M L
Neurologic complications of HIV infection.
American family physician 1990;41(2):517-36.
1990: Levy R M; Mills C M; Posin J P; Moore S G; Rosenblum M L; Bredesen D E
The efficacy and clinical impact of brain imaging in neurologically symptomatic AIDS patients: a prospective CT/MRI study.
Journal of acquired immune deficiency syndromes 1990;3(5):461-71.
1989: Ho D D; Bredesen D E; Vinters H V; Daar E S
The acquired immunodeficiency syndrome (AIDS) dementia complex.
Annals of internal medicine 1989;111(5):400-10.
1989: Engstrom J W; Lowenstein D H; Bredesen D E
Cerebral infarctions and transient neurologic deficits associated with acquired immunodeficiency syndrome.
The American journal of medicine 1989;86(5):528-32.
1989: Levy R M; Bredesen D E; Rosenblum M L; Davis R L
Central nervous system disorders in AIDS.
Immunology series 1989;44():371-401.
1989: Levy R M; Bredesen D E
Controversies in HIV-related central nervous system disease: neuropsychological aspects of HIV-1 infection.
AIDS clinical review 1989;():151-91.
1988: Bredesen D E; Levy R M; Rosenblum M L
The neurology of human immunodeficiency virus infection.
The Quarterly journal of medicine 1988;68(257):665-77.
1988: Scott M R; Butler D A; Bredesen D E; Wälchli M; Hsiao K K; Prusiner S B
Prion protein gene expression in cultured cells.
Protein engineering 1988;2(1):69-76.
1988: Rosenblum M L; Levy R M; Bredesen D E
Neurosurgical implications of the acquired immunodeficiency syndrome (AIDS).
Clinical neurosurgery 1988;34():419-45.
1988: Levy R M; Bredesen D E
Central nervous system dysfunction in acquired immunodeficiency syndrome.
Journal of acquired immune deficiency syndromes 1988;1(1):41-64.
1988: Rosenblum M L; Levy R M; Bredesen D E; So Y T; Wara W; Ziegler J L
Primary central nervous system lymphomas in patients with AIDS.
Annals of neurology 1988;23 Suppl():S13-6.
1988: Levy R M; Bredesen D E; Rosenblum M L
Opportunistic central nervous system pathology in patients with AIDS.
Annals of neurology 1988;23 Suppl():S7-12.
1985: Dix R D; Bredesen D E; Erlich K S; Mills J
Recovery of herpesviruses from cerebrospinal fluid of immunodeficient homosexual men.
Annals of neurology 1985;18(5):611-4.
1985: Parry G J; Bredesen D E
Sensory neuropathy with low-dose pyridoxine.
Neurology 1985;35(10):1466-8.
1985: Levy R M; Bredesen D E; Rosenblum M L
Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature.
Journal of neurosurgery 1985;62(4):475-95.
1984: Raskin N H; Bredesen D; Ehrenfeld W K; Kerlan R K
Periodic confusion caused by congenital extrahepatic portacaval shunt.
Neurology 1984;34(5):666-9.
1983: Cutler J R; Bredesen D E; Edwards R; Simon R P
Failure of naloxone to reverse vascular neurologic deficits.
Neurology 1983;33(11):1517-8.
1978: McCarty K S; Bredesen D E; Vogel F S
Neoplasms of the anterior pituitary.
Neurosurgery 1978;3(1):96-104.

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