FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Robert Winslow

Research Profile

Chemicals & Drugs

Living Beings

Physiology

Disorders

Blood Pressure

Procedures

Whole Blood Exchange Transfusion

Co-author Network

Publications

TOP 3
Robert M Winslow
Oxygen: the poison is in the dose.
Mark A Young; Jeff Lohman; Ashok Malavalli; Kim Vandegriff; Robert M Winslow
Hemospan improves outcome in a model of perioperative hemodilution and blood loss in the rat: comparison with hydroxyethyl starch.
Kim Vandegriff; Ashok Malavalli; Gnel M Mkrtchyan; Stephanie N Spann; Dale A Baker; Robert M Winslow
Sites of modification of hemospan, a poly(ethylene glycol)-modified human hemoglobin for use as an oxygen therapeutic.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Robert Winslow (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Robert M Winslow
Oxygen: the poison is in the dose.
Transfusion 2013;53(2):424-37.
2009: Mark A Young; Jeff Lohman; Ashok Malavalli; Kim Vandegriff; Robert M Winslow
Hemospan improves outcome in a model of perioperative hemodilution and blood loss in the rat: comparison with hydroxyethyl starch.
Journal of cardiothoracic and vascular anesthesia 2009;23(3):339-47.
2008: Kim Vandegriff; Ashok Malavalli; Gnel M Mkrtchyan; Stephanie N Spann; Dale A Baker; Robert M Winslow
Sites of modification of hemospan, a poly(ethylene glycol)-modified human hemoglobin for use as an oxygen therapeutic.
Bioconjugate chemistry 2008;19(11):2163-70.
2008: Robert M Winslow
Cell-free oxygen carriers: scientific foundations, clinical development, and new directions.
Biochimica et biophysica acta 2008;1784(10):1382-6.
2008: Robert M Winslow; Marcos Intaglietta
Red cell age and loss of function: advance or SNO-job?
Transfusion 2008;48(3):411-4.
2008: Christina Olofsson; EB Nygårds; Sari Ponzer; Bengt Fagrell; Robert J Przybelski; Peter E Keipert; Nancy Winslow; Robert M Winslow
A randomized, single-blind, increasing dose safety trial of an oxygen-carrying plasma expander (Hemospan) administered to orthopaedic surgery patients with spinal anaesthesia.
Transfusion medicine (Oxford, England) 2008;18(1):28-39.
2008: Dmitri I Svergun; Fredrik Ekström; Kim Vandegriff; Ashok Malavalli; Dale A Baker; Calle Nilsson; Robert M Winslow
Solution structure of poly(ethylene) glycol-conjugated hemoglobin revealed by small-angle X-ray scattering: implications for a new oxygen therapeutic.
Biophysical journal 2008;94(1):173-81.
2007: Mark A Young; Louis Riddez; B Thomas Kjellström; Robert M Winslow
Effect of maleimide-polyethylene glycol hemoglobin (MP4) on hemodynamics and acid-base status after uncontrolled hemorrhage in anesthetized swine: comparison with crystalloid and blood.
The Journal of trauma 2007;63(6):1234-44.
2007: Mark A Young; Ashok Malavalli; Nancy Winslow; Kim Vandegriff; Robert M Winslow
Toxicity and hemodynamic effects after single dose administration of MalPEG-hemoglobin (MP4) in rhesus monkeys.
Translational research : the journal of laboratory and clinical medicine 2007;149(6):333-42.
2007: Russell H Cole; Kim Vandegriff; Andrew J Szeri; Omer Savaş; Dale A Baker; Robert M Winslow
A quantitative framework for the design of acellular hemoglobins as blood substitutes: implications of dynamic flow conditions.
Biophysical chemistry 2007;128(1):63-74.
2006: Christina Olofsson; Torbjörn Ahl; Torsten Johansson; Sune Larsson; Per Nellgård; Sari Ponzer; Bengt Fagrell; Robert J Przybelski; Peter E Keipert; Nancy Winslow; Robert M Winslow
A multicenter clinical study of the safety and activity of maleimide-polyethylene glycol-modified Hemoglobin (Hemospan) in patients undergoing major orthopedic surgery.
Anesthesiology 2006;105(6):1153-63.
2006: Amy Tsai; Pedro Cabrales; Belur N Manjula; Seetharama A Acharya; Robert M Winslow; Marcos Intaglietta
Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers.
Blood 2006;108(10):3603-10.
2006: Kim Vandegriff; Ashok Malavalli; Charles Minn; Eva Jiang; Jeff Lohman; Mark A Young; Michele Samaja; Robert M Winslow
Oxidation and haem loss kinetics of poly(ethylene glycol)-conjugated haemoglobin (MP4): dissociation between in vitro and in vivo oxidation rates.
The Biochemical journal 2006;399(3):463-71.
2005: Pedro Cabrales; Amy Tsai; Robert M Winslow; Marcos Intaglietta
Extreme hemodilution with PEG-hemoglobin vs. PEG-albumin.
American journal of physiology. Heart and circulatory physiology 2005;289(6):H2392-400.
2005: Mark A Young; Louis Riddez; B Thomas Kjellström; Jenny Bursell; Ford Winslow; Jeff Lohman; Robert M Winslow
MalPEG-hemoglobin (MP4) improves hemodynamics, acid-base status, and survival after uncontrolled hemorrhage in anesthetized swine.
Critical care medicine 2005;33(8):1794-804.
2005: Pedro Cabrales; Amy Tsai; Robert M Winslow; Marcos Intaglietta
Effects of extreme hemodilution with hemoglobin-based O2 carriers on microvascular pressure.
American journal of physiology. Heart and circulatory physiology 2005;288(5):H2146-53.
2005: Magnus Björkholm; Bengt Fagrell; Robert J Przybelski; Nancy Winslow; Mark Young; Robert M Winslow
A phase I single blind clinical trial of a new oxygen transport agent (MP4), human hemoglobin modified with maleimide-activated polyethylene glycol.
Haematologica 2005;90(4):505-15.
2005: Seetharama A Acharya; Joel Mitchel Friedman; Belur N Manjula; Marcos Intaglietta; Amy Tsai; Robert M Winslow; Ashok Malavalli; Kim Vandegriff; Paul K Smith
Enhanced molecular volume of conservatively pegylated Hb: (SP-PEG5K)6-HbA is non-hypertensive.
Artificial cells, blood substitutes, and immobilization biotechnology 2005;33(3):239-55.
2004: Reto Wettstein; Pedro Cabrales; Dominique Erni; Amy Tsai; Robert M Winslow; Marcos Intaglietta
Resuscitation from hemorrhagic shock with MalPEG-albumin: comparison with MalPEG-hemoglobin.
Shock (Augusta, Ga.) 2004;22(4):351-7.
2004: Robert M Winslow; Jeff Lohman; Ashok Malavalli; Kim Vandegriff
Comparison of PEG-modified albumin and hemoglobin in extreme hemodilution in the rat.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;97(4):1527-34.
2004: Kim Vandegriff; Andrea Bellelli; Michele Samaja; Ashok Malavalli; Maurizio Brunori; Robert M Winslow
Kinetics of NO and O2 binding to a maleimide poly(ethylene glycol)-conjugated human haemoglobin.
The Biochemical journal 2004;382(Pt 1):183-9.
2004: Dan Drobin; B Thomas Kjellstrom; Elisabeth Malm; Ashok Malavalli; Jeff Lohman; Kim Vandegriff; Mark A Young; Robert M Winslow
Hemodynamic response and oxygen transport in pigs resuscitated with maleimide-polyethylene glycol-modified hemoglobin (MP4).
Journal of applied physiology (Bethesda, Md. : 1985) 2004;96(5):1843-53.
2003: Robert M Winslow
Alternative oxygen therapeutics: products, status of clinical trials, and future prospects.
Current hematology reports 2003;2(6):503-10.
2003: Amy Tsai; Pedro Cabrales; Robert M Winslow; Marcos Intaglietta
Microvascular oxygen distribution in awake hamster window chamber model during hyperoxia.
American journal of physiology. Heart and circulatory physiology 2003;285(4):H1537-45.
2003: Amy Tsai; Kim Vandegriff; Marcos Intaglietta; Robert M Winslow
Targeted O2 delivery by low-P50 hemoglobin: a new basis for O2 therapeutics.
American journal of physiology. Heart and circulatory physiology 2003;285(4):H1411-9.
2003: Reto Wettstein; Amy Tsai; Dominique Erni; Robert M Winslow; Marcos Intaglietta
Resuscitation with polyethylene glycol-modified human hemoglobin improves microcirculatory blood flow and tissue oxygenation after hemorrhagic shock in awake hamsters.
Critical care medicine 2003;31(6):1824-30.
2003: Kim Vandegriff; Ashok Malavalli; Jerod Wooldridge; Jeff Lohman; Robert M Winslow
MP4, a new nonvasoactive PEG-Hb conjugate.
Transfusion 2003;43(4):509-16.
2003: Belur N Manjula; Amy Tsai; R Upadhya; Krishnaveni Perumalsamy; Paul K Smith; Ashok Malavalli; Kim Vandegriff; Robert M Winslow; Marcos Intaglietta; Muthuchidambaram Prabhakaran; Joel Mitchel Friedman; Seetharama A Acharya
Site-specific PEGylation of hemoglobin at Cys-93(beta): correlation between the colligative properties of the PEGylated protein and the length of the conjugated PEG chain.
Bioconjugate chemistry 2003;14(2):464-72.
2001: M R McCarthy; Kim Vandegriff; Robert M Winslow
The role of facilitated diffusion in oxygen transport by cell-free hemoglobins: implications for the design of hemoglobin-based oxygen carriers.
Biophysical chemistry 2001;92(1-2):103-17.
1999: Robert M Winslow
New transfusion strategies: red cell substitutes.
Annual review of medicine 1999;50():337-53.
1998: Roberto Motterlini; A Gonzales; Roberta Foresti; James E Clark; Colin J Green; Robert M Winslow
Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo.
Circulation research 1998;83(5):568-77.
1998: Robert M Winslow; A Gonzales; Maria L Gonzales; MD Magde; M McCarthy; RJ Rohlfs; Kim Vandegriff
Vascular resistance and the efficacy of red cell substitutes in a rat hemorrhage model.
Journal of applied physiology (Bethesda, Md. : 1985) 1998;85(3):993-1003.
1998: Roberto Motterlini; H Kerger; Colin J Green; Robert M Winslow; Marcos Intaglietta
Depression of endothelial and smooth muscle cell oxygen consumption by endotoxin.
The American journal of physiology 1998;275(3 Pt 2):H776-82.
1998: RJ Rohlfs; E Bruner; A Chiu; A Gonzales; Maria L Gonzales; Douglas Magde; MD Magde; Kim Vandegriff; Robert M Winslow
Arterial blood pressure responses to cell-free hemoglobin solutions and the reaction with nitric oxide.
The Journal of biological chemistry 1998;273(20):12128-34.
1998: Kim Vandegriff; RJ Rohlfs; MD Magde; Robert M Winslow
Hemoglobin-oxygen equilibrium curves measured during enzymatic oxygen consumption.
Analytical biochemistry 1998;256(1):107-16.
1997: Kim Vandegriff; M McCarthy; RJ Rohlfs; Robert M Winslow
Colloid osmotic properties of modified hemoglobins: chemically cross-linked versus polyethylene glycol surface-conjugated.
Biophysical chemistry 1997;69(1):23-30.
1997: R Migita; A Gonzales; Maria L Gonzales; Kim Vandegriff; Robert M Winslow
Blood volume and cardiac index in rats after exchange transfusion with hemoglobin-based oxygen carriers.
Journal of applied physiology (Bethesda, Md. : 1985) 1997;82(6):1995-2002.
1997: H Kerger; Darin J Saltzman; A Gonzales; Amy Tsai; K van Ackern; Robert M Winslow; Marcos Intaglietta
Microvascular oxygen delivery and interstitial oxygenation during sodium pentobarbital anesthesia.
Anesthesiology 1997;86(2):372-86.
1997: H Kerger; Amy Tsai; Darin J Saltzman; Robert M Winslow; Marcos Intaglietta
Fluid resuscitation with O2 vs. non-O2 carriers after 2 h of hemorrhagic shock in conscious hamsters.
The American journal of physiology 1997;272(1 Pt 2):H525-37.
1996: Lois R Manning; W T Jenkins; John R Hess; Kim Vandegriff; Robert M Winslow; James M Manning
Subunit dissociations in natural and recombinant hemoglobins.
Protein science : a publication of the Protein Society 1996;5(4):775-81.
1996: Roberto Motterlini; Kim Vandegriff; Robert M Winslow
Hemoglobin-nitric oxide interaction and its implications.
Transfusion medicine reviews 1996;10(2):77-84.
1996: Roberto Motterlini; Roberta Foresti; Marcos Intaglietta; Robert M Winslow
NO-mediated activation of heme oxygenase: endogenous cytoprotection against oxidative stress to endothelium.
The American journal of physiology 1996;270(1 Pt 2):H107-14.
1995: Robert M Winslow
Blood substitutes--a moving target.
Nature medicine 1995;1(11):1212-5.
1995: W Kaca; R I Roth; Kim Vandegriff; G C Chen; Frans A Kuypers; Robert M Winslow; J Levin
Effects of bacterial endotoxin on human cross-linked and native hemoglobins.
Biochemistry 1995;34(35):11176-85.
1995: Roberto Motterlini; Roberta Foresti; Kim Vandegriff; Marcos Intaglietta; Robert M Winslow
Oxidative-stress response in vascular endothelial cells exposed to acellular hemoglobin solutions.
The American journal of physiology 1995;269(2 Pt 2):H648-55.
1995: H Kerger; I P Torres Filho; marcelo rivas; Robert M Winslow; Marcos Intaglietta
Systemic and subcutaneous microvascular oxygen tension in conscious Syrian golden hamsters.
The American journal of physiology 1995;268(2 Pt 2):H802-10.
1995: H Yanase; Lois R Manning; Kim Vandegriff; Robert M Winslow; James M Manning
A recombinant human hemoglobin with asparagine-102(beta) substituted by alanine has a limiting low oxygen affinity, reduced marginally by chloride.
Protein science : a publication of the Protein Society 1995;4(1):21-8.
1995: Roberto Motterlini; Roberta Foresti; Kim Vandegriff; Robert M Winslow
The autoxidation of alpha alpha cross-linked hemoglobin: a possible role in the oxidative stress to endothelium.
Artificial cells, blood substitutes, and immobilization biotechnology 1995;23(3):291-301.
1994: H Yanase; Sean M Cahill; J J Martin de Llano; Lois R Manning; K Schneider; Brian T Chait; Kim Vandegriff; Robert M Winslow; James M Manning
Properties of a recombinant human hemoglobin with aspartic acid 99(beta), an important intersubunit contact site, substituted by lysine.
Protein science : a publication of the Protein Society 1994;3(8):1213-23.
1994: Peter Keipert; C L Gomez; A Gonzales; V W MacDonald; John R Hess; Robert M Winslow
Diaspirin cross-linked hemoglobin: tissue distribution and long-term excretion after exchange transfusion.
The Journal of laboratory and clinical medicine 1994;123(5):701-11.
1994: Robert M Winslow; A Murray; C C Gibson
Oxygen equilibrium curve of concentrated hemoglobin.
Methods in enzymology 1994;232():486-95.
1994: Robert M Winslow; K W Chapman
Pilot-scale preparation of hemoglobin solutions.
Methods in enzymology 1994;231():3-16.
1994: Kim Vandegriff; D F Wallach; Robert M Winslow
Encapsulation of hemoglobin in non-phospholipid vesicles.
Artificial cells, blood substitutes, and immobilization biotechnology 1994;22(3):849-54.
1994: Amy Tsai; B Friesenecker; Robert M Winslow; Marcos Intaglietta
Functional capillary density changes during blood substitution with alpha alpha Hb and dextran 70: influence on oxygen delivery.
Artificial cells, blood substitutes, and immobilization biotechnology 1994;22(3):841-7.
1993: Peter Keipert; A Gonzales; C L Gomez; V W MacDonald; John R Hess; Robert M Winslow
Acute changes in systemic blood pressure and urine output of conscious rats following exchange transfusion with diaspirin-crosslinked hemoglobin solution.
Transfusion 1993;33(9):701-8.
1992: D J Smith; Robert M Winslow
Effects of extraerythrocytic hemoglobin and its components on mononuclear cell procoagulant activity.
The Journal of laboratory and clinical medicine 1992;119(2):176-82.
1992: V W MacDonald; Robert M Winslow
Oxygen delivery and myocardial function in rabbit hearts perfused with cell-free hemoglobin.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(2):476-83.
1992: Peter Keipert; C L Gomez; A Gonzales; V W Macdonald; Robert M Winslow
The role of the kidneys in the excretion of chemically modified hemoglobins.
Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology 1992;20(2-4):737-45.
1992: J C Hsia; D L Song; S S Er; Lawrence T Wong; Peter Keipert; C L Gomez; A Gonzales; V W Macdonald; John R Hess; Robert M Winslow
Pharmacokinetic studies in the rat on a o-raffinose polymerized human hemoglobin.
Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology 1992;20(2-4):587-95.
1992: John R Hess; V W MacDonald; Robert M Winslow
Dehydration and shock: an animal model of hemorrhage and resuscitation of battlefield injury.
Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology 1992;20(2-4):499-502.
1992: K W Chapman; S M Snell; R G Jesse; J K Morano; J Everse; Robert M Winslow
Pilot scale production of pyrogen-free human hemoglobin for research.
Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology 1992;20(2-4):415-21.
1992: Robert M Winslow
Potential clinical applications for blood substitutes.
Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology 1992;20(2-4):205-17.
1991: Kim Vandegriff; Y C Le Tellier; Robert M Winslow; RJ Rohlfs; J S Olson
Determination of the rate and equilibrium constants for oxygen and carbon monoxide binding to R-state human hemoglobin cross-linked between the alpha subunits at lysine 99.
The Journal of biological chemistry 1991;266(26):17049-59.
1991: Lois R Manning; S Morgan; Ronald C Beavis; Brian T Chait; James M Manning; John R Hess; M Cross; D L Currell; M A Marini; Robert M Winslow
Preparation, properties, and plasma retention of human hemoglobin derivatives: comparison of uncrosslinked carboxymethylated hemoglobin with crosslinked tetrameric hemoglobin.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3329-33.
1991: John R Hess; C E Wade; Robert M Winslow
Filtration-assisted exchange transfusion using alpha alpha Hb, an erythrocyte substitute.
Journal of applied physiology (Bethesda, Md. : 1985) 1991;70(4):1639-44.
1991: Kim Vandegriff; L Benazzi; Marilena Ripamonti; Michele Perrella; Y C Le Tellier; A Zegna; Robert M Winslow
Carbon dioxide binding to human hemoglobin cross-linked between the alpha chains.
The Journal of biological chemistry 1991;266(5):2697-700.
1990: V W Macdonald; Robert M Winslow; M A Marini; M T Klinker
Coronary vasoconstrictor activity of purified and modified human hemoglobin.
Biomaterials, artificial cells, and artificial organs 1990;18(2):263-82.
1989: Kim Vandegriff; F Medina; M A Marini; Robert M Winslow
Equilibrium oxygen binding to human hemoglobin cross-linked between the alpha chains by bis(3,5-dibromosalicyl) fumarate.
The Journal of biological chemistry 1989;264(30):17824-33.
1989: Robert M Winslow; K W Chapman; C C Gibson; Michele Samaja; C C Monge; E Goldwasser; M Sherpa; F D Blume; R Santolaya
Different hematologic responses to hypoxia in Sherpas and Quechua Indians.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(4):1561-9.
1989: Robert M Winslow; M L Swenberg; J Benson; Michele Perrella; L Benazzi
Gas exchange properties of goat hemoglobins A and C.
The Journal of biological chemistry 1989;264(9):4812-7.
1989: Robert M Winslow
Blood substitutes--minireview.
Progress in clinical and biological research 1989;319():305-21; discussion 322-3.
1989: John R Hess; S O Fadare; L S Tolentino; N R Bangal; Robert M Winslow
The intravascular persistence of crosslinked human hemoglobin.
Progress in clinical and biological research 1989;319():351-7; discussion 358-60.
1988: Robert M Winslow
Optimal hematologic variables for oxygen transport, including P50, hemoglobin cooperativity, hematocrit, acid-base status, and cardiac function.
Biomaterials, artificial cells, and artificial organs 1988;16(1-3):149-71.