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Wolfgang Wintermeyer

Research Profile

Anatomy

Ribosomes

Living Beings

Escherichia coli

Chemicals & Drugs

Concepts & Ideas

Physiology

Protein Biosynthesis

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Hydrolysis

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Publications

TOP 3
Wolf Holtkamp; Sejeong Lee; Marina V Rodnina; Tamara Senyushkina; Thomas Bornemann; Wolfgang Wintermeyer
Dynamic switch of the signal recognition particle from scanning to targeting.
Georgina Cox; Thomas A Edwards; Steve W Homans; Huw Thomas Jenkins; Frank Peske; Marina V Rodnina; Andreas Savelsbergh; Gary S Thompson; Wolfgang Wintermeyer; Alexander John O'Neill
Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid.
Stephan Kuhlenkoetter; Wolfgang Wintermeyer; Marina V Rodnina
Different substrate-dependent transition states in the active site of the ribosome.

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All Publications

2012: Wolf Holtkamp; Sejeong Lee; Marina V Rodnina; Tamara Senyushkina; Thomas Bornemann; Wolfgang Wintermeyer
Dynamic switch of the signal recognition particle from scanning to targeting.
Nature structural & molecular biology 2012;19(12):1332-7.
2012: Georgina Cox; Thomas A Edwards; Steve W Homans; Huw Thomas Jenkins; Frank Peske; Marina V Rodnina; Andreas Savelsbergh; Gary S Thompson; Wolfgang Wintermeyer; Alexander John O'Neill
Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(6):2102-7.
2011: Stephan Kuhlenkoetter; Wolfgang Wintermeyer; Marina V Rodnina
Different substrate-dependent transition states in the active site of the ribosome.
Nature 2011;476(7360):351-4.
2011: Marina V Rodnina; Wolfgang Wintermeyer
The ribosome as a molecular machine: the mechanism of tRNA-mRNA movement in translocation.
Biochemical Society transactions 2011;39(2):658-62.
2010: Niels Fischer; Andrey Konevega; Wolfgang Wintermeyer; Marina V Rodnina; Holger Stark
Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy.
Nature 2010;466(7304):329-33.
2010: Pohl Milon; Marcello Carotti; Andrey L Konevega; Wolfgang Wintermeyer; Marina V Rodnina; Claudio O Gualerzi
The ribosome-bound initiation factor 2 recruits initiator tRNA to the 30S initiation complex.
EMBO reports 2010;11(4):312-6.
2010: Marina V Rodnina; Wolfgang Wintermeyer
The ribosome goes Nobel.
Trends in biochemical sciences 2010;35(1):1-5.
2009: Marina V Rodnina; Wolfgang Wintermeyer
Recent mechanistic insights into eukaryotic ribosomes.
Current opinion in cell biology 2009;21(3):435-43.
2009: Andreas Savelsbergh; Marina V Rodnina; Wolfgang Wintermeyer
Distinct functions of elongation factor G in ribosome recycling and translocation.
RNA (New York, N.Y.) 2009;15(5):772-80.
2008: Patricia Julián; Andrey L Konevega; Sjors H W Scheres; Melisa Lázaro; David Gil; Wolfgang Wintermeyer; Marina V Rodnina; Mikel Valle
Structure of ratcheted ribosomes with tRNAs in hybrid states.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(44):16924-7.
2008: Lorna E Lancaster; Andreas Savelsbergh; Colin Kleanthous; Wolfgang Wintermeyer; Marina V Rodnina
Colicin E3 cleavage of 16S rRNA impairs decoding and accelerates tRNA translocation on Escherichia coli ribosomes.
Molecular microbiology 2008;69(2):390-401.
2008: Thomas Bornemann; Johannes Jöckel; Marina V Rodnina; Wolfgang Wintermeyer
Signal sequence-independent membrane targeting of ribosomes containing short nascent peptides within the exit tunnel.
Nature structural & molecular biology 2008;15(5):494-9.
2007: Andrey Konevega; Niels Fischer; Yuri P Semenkov; Holger Stark; Wolfgang Wintermeyer; Marina V Rodnina
Spontaneous reverse movement of mRNA-bound tRNA through the ribosome.
Nature structural & molecular biology 2007;14(4):318-24.
2007: Marina V Rodnina; Malte Beringer; Wolfgang Wintermeyer
How ribosomes make peptide bonds.
Trends in biochemical sciences 2007;32(1):20-6.
2007: Lorna E Lancaster; Wolfgang Wintermeyer; Marina V Rodnina
Colicins and their potential in cancer treatment.
Blood cells, molecules & diseases 2007;38(1):15-8.
2006: Andrew Kubarenko; Petr V Sergiev; Wolfgang Wintermeyer; Olga A Dontsova; Marina V Rodnina
Involvement of helix 34 of 16 S rRNA in decoding and translocation on the ribosome.
The Journal of biological chemistry 2006;281(46):35235-44.
2006: Berthold Wilden; Andreas Savelsbergh; Marina V Rodnina; Wolfgang Wintermeyer
Role and timing of GTP binding and hydrolysis during EF-G-dependent tRNA translocation on the ribosome.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(37):13670-5.
2006: Marina V Rodnina; Malte Beringer; Wolfgang Wintermeyer
Mechanism of peptide bond formation on the ribosome.
Quarterly reviews of biophysics 2006;39(3):203-25.
2005: Andreas Savelsbergh; Dagmar Mohr; Ute Kothe; Wolfgang Wintermeyer; Marina V Rodnina
Control of phosphate release from elongation factor G by ribosomal protein L7/12.
The EMBO journal 2005;24(24):4316-23.
2005: Shan-Qing Gu; Johannes Jöckel; Philipp Beinker; Jens Warnecke; Yuri P Semenkov; Marina V Rodnina; Wolfgang Wintermeyer
Conformation of 4.5S RNA in the signal recognition particle and on the 30S ribosomal subunit.
RNA (New York, N.Y.) 2005;11(9):1374-84.
2005: Iwona Buskiewicz; Frank Peske; Hans-Joachim Wieden; Ignacy Gryczynski; Marina V Rodnina; Wolfgang Wintermeyer
Conformations of the signal recognition particle protein Ffh from Escherichia coli as determined by FRET.
Journal of molecular biology 2005;351(2):417-30.
2005: Iwona Buskiewicz; Andrew Kubarenko; Frank Peske; Marina V Rodnina; Wolfgang Wintermeyer
Domain rearrangement of SRP protein Ffh upon binding 4.5S RNA and the SRP receptor FtsY.
RNA (New York, N.Y.) 2005;11(6):947-57.
2005: Frank Peske; Marina V Rodnina; Wolfgang Wintermeyer
Sequence of steps in ribosome recycling as defined by kinetic analysis.
Molecular cell 2005;18(4):403-12.
2004: Frank Peske; Andreas Savelsbergh; Vladimir I Katunin; Marina V Rodnina; Wolfgang Wintermeyer
Conformational changes of the small ribosomal subunit during elongation factor G-dependent tRNA-mRNA translocation.
Journal of molecular biology 2004;343(5):1183-94.
2004: Wolfgang Wintermeyer; Frank Peske; Malte Beringer; Kirill B Gromadski; Andreas Savelsbergh; Marina V Rodnina
Mechanisms of elongation on the ribosome: dynamics of a macromolecular machine.
Biochemical Society transactions 2004;32(Pt 5):733-7.
2004: Iwona Buskiewicz; Elke Deuerling; Shan-Qing Gu; Johannes Jöckel; Marina V Rodnina; Bernd Bukau; Wolfgang Wintermeyer
Trigger factor binds to ribosome-signal-recognition particle (SRP) complexes and is excluded by binding of the SRP receptor.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):7902-6.
2004: Andrey Konevega; Natalia G Soboleva; Valentin I Makhno; Yuri P Semenkov; Wolfgang Wintermeyer; Marina V Rodnina; Vladimir I Katunin
Purine bases at position 37 of tRNA stabilize codon-anticodon interaction in the ribosomal A site by stacking and Mg2+-dependent interactions.
RNA (New York, N.Y.) 2004;10(1):90-101.
2003: Andrew Kubarenko; IN Lavrik; Petr V Sergiev; M Heupl; Marina V Rodnina; Wolfgang Wintermeyer; Alexey A Bogdanov; Olga A Dontsova
Contacts of elongation factor G with the small ribosomal subunit: cross-linking approach.
Doklady. Biochemistry and biophysics 2003;393():312-4.
2003: Malte Beringer; Sarah Adio; Wolfgang Wintermeyer; Marina V Rodnina
The G2447A mutation does not affect ionization of a ribosomal group taking part in peptide bond formation.
RNA (New York, N.Y.) 2003;9(8):919-22.
2003: Marina V Rodnina; Wolfgang Wintermeyer
Peptide bond formation on the ribosome: structure and mechanism.
Current opinion in structural biology 2003;13(3):334-40.
2003: Andreas Savelsbergh; Vladimir I Katunin; Dagmar Mohr; Frank Peske; Marina V Rodnina; Wolfgang Wintermeyer
An elongation factor G-induced ribosome rearrangement precedes tRNA-mRNA translocation.
Molecular cell 2003;11(6):1517-23.
2003: Shan-Qing Gu; Frank Peske; Hans-Joachim Wieden; Marina V Rodnina; Wolfgang Wintermeyer
The signal recognition particle binds to protein L23 at the peptide exit of the Escherichia coli ribosome.
RNA (New York, N.Y.) 2003;9(5):566-73.
2002: Holger Stark; Marina V Rodnina; Hans-Joachim Wieden; Friedrich Zemlin; Wolfgang Wintermeyer; Marin van Heel
Ribosome interactions of aminoacyl-tRNA and elongation factor Tu in the codon-recognition complex.
Nature structural biology 2002;9(11):849-54.
2002: Vladimir I Katunin; Andreas Savelsbergh; Marina V Rodnina; Wolfgang Wintermeyer
Coupling of GTP hydrolysis by elongation factor G to translocation and factor recycling on the ribosome.
Biochemistry 2002;41(42):12806-12.
2002: Dagmar Mohr; Wolfgang Wintermeyer; Marina V Rodnina
GTPase activation of elongation factors Tu and G on the ribosome.
Biochemistry 2002;41(41):12520-8.
2002: Marina V Rodnina; Tina Daviter; Kirill B Gromadski; Wolfgang Wintermeyer
Structural dynamics of ribosomal RNA during decoding on the ribosome.
Biochimie 2002;84(8):745-54.
2002: Vladimir I Katunin; Gregory W Muth; Scott A Strobel; Wolfgang Wintermeyer; Marina V Rodnina
Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome.
Molecular cell 2002;10(2):339-46.
2001: A B Matassova; Marina V Rodnina; Wolfgang Wintermeyer
Elongation factor G-induced structural change in helix 34 of 16S rRNA related to translocation on the ribosome.
RNA (New York, N.Y.) 2001;7(12):1879-85.
2001: Marina V Rodnina; Iu P Semenkov; Andreas Savelsbergh; Vladimir I Katunin; Frank Peske; Berthold Wilden; Wolfgang Wintermeyer
[Mechanism of tRNA translocation on the ribosome].
Molekuliarnaia biologiia 2001;35(4):655-65.
2001: JR Jagath; Natalia Matassova; Erik de Leeuw; J M Warnecke; Georg Lentzen; Marina V Rodnina; Joen Luirink; Wolfgang Wintermeyer
Important role of the tetraloop region of 4.5S RNA in SRP binding to its receptor FtsY.
RNA (New York, N.Y.) 2001;7(2):293-301.
2001: Hans-Joachim Wieden; Wolfgang Wintermeyer; Marina V Rodnina
A common structural motif in elongation factor Ts and ribosomal protein L7/12 may be involved in the interaction with elongation factor Tu.
Journal of molecular evolution 2001;52(2):129-36.
2001: Marina V Rodnina; Wolfgang Wintermeyer
Ribosome fidelity: tRNA discrimination, proofreading and induced fit.
Trends in biochemical sciences 2001;26(2):124-30.
2001: Wolfgang Wintermeyer; Andreas Savelsbergh; Yuri P Semenkov; Vladimir I Katunin; Marina V Rodnina
Mechanism of elongation factor G function in tRNA translocation on the ribosome.
Cold Spring Harbor symposia on quantitative biology 2001;66():449-58.
2001: Marina V Rodnina; Wolfgang Wintermeyer
Fidelity of aminoacyl-tRNA selection on the ribosome: kinetic and structural mechanisms.
Annual review of biochemistry 2001;70():415-35.
2000: Yuri P Semenkov; Marina V Rodnina; Wolfgang Wintermeyer
Energetic contribution of tRNA hybrid state formation to translocation catalysis on the ribosome.
Nature structural biology 2000;7(11):1027-31.
2000: Frank Peske; Natalia Matassova; Andreas Savelsbergh; Marina V Rodnina; Wolfgang Wintermeyer
Conformationally restricted elongation factor G retains GTPase activity but is inactive in translocation on the ribosome.
Molecular cell 2000;6(2):501-5.
2000: Andreas Savelsbergh; Natalia Matassova; Marina V Rodnina; Wolfgang Wintermeyer
Role of domains 4 and 5 in elongation factor G functions on the ribosome.
Journal of molecular biology 2000;300(4):951-61.
2000: D Mohr; Wolfgang Wintermeyer; Marina V Rodnina
Arginines 29 and 59 of elongation factor G are important for GTP hydrolysis or translocation on the ribosome.
The EMBO journal 2000;19(13):3458-64.
2000: Jerneja Tomsic; Luca Vitali; Tina Daviter; Andreas Savelsbergh; Roberto Spurio; P Striebeck; Wolfgang Wintermeyer; Marina V Rodnina; Claudio O Gualerzi
Late events of translation initiation in bacteria: a kinetic analysis.
The EMBO journal 2000;19(9):2127-36.
2000: Marina V Rodnina; Holger Stark; Andreas Savelsbergh; Hans-Joachim Wieden; Dagmar Mohr; Natalia Matassova; Frank Peske; Tina Daviter; C O Gualerzi; Wolfgang Wintermeyer
GTPases mechanisms and functions of translation factors on the ribosome.
Biological chemistry 2000;381(5-6):377-87.
2000: O Piepenburg; T Pape; JA Pleiss; Wolfgang Wintermeyer; Olke C Uhlenbeck; Marina V Rodnina
Intact aminoacyl-tRNA is required to trigger GTP hydrolysis by elongation factor Tu on the ribosome.
Biochemistry 2000;39(7):1734-8.
2000: Holger Stark; Marina V Rodnina; Hans-Joachim Wieden; Marin van Heel; Wolfgang Wintermeyer
Large-scale movement of elongation factor G and extensive conformational change of the ribosome during translocation.
Cell 2000;100(3):301-9.
2000: T Pape; Wolfgang Wintermeyer; Marina V Rodnina
Conformational switch in the decoding region of 16S rRNA during aminoacyl-tRNA selection on the ribosome.
Nature structural biology 2000;7(2):104-7.
2000: JR Jagath; Marina V Rodnina; Wolfgang Wintermeyer
Conformational changes in the bacterial SRP receptor FtsY upon binding of guanine nucleotides and SRP.
Journal of molecular biology 2000;295(4):745-53.
2000: Andreas Savelsbergh; Dagmar Mohr; Berthold Wilden; Wolfgang Wintermeyer; Marina V Rodnina
Stimulation of the GTPase activity of translation elongation factor G by ribosomal protein L7/12.
The Journal of biological chemistry 2000;275(2):890-4.
2000: Wolfgang Wintermeyer; Marina V Rodnina
Translational elongation factor G: a GTP-driven motor of the ribosome.
Essays in biochemistry 2000;35():117-29.
1999: Marina V Rodnina; Andreas Savelsbergh; Natalia Matassova; Vladimir I Katunin; Yuri P Semenkov; Wolfgang Wintermeyer
Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9586-90.
1999: Natalia Matassova; Marina V Rodnina; Rainer Endermann; H P Kroll; U Pleiss; H Wild; Wolfgang Wintermeyer
Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors.
RNA (New York, N.Y.) 1999;5(7):939-46.
1999: T Pape; Wolfgang Wintermeyer; Marina V Rodnina
Induced fit in initial selection and proofreading of aminoacyl-tRNA on the ribosome.
The EMBO journal 1999;18(13):3800-7.
1999: Marina V Rodnina; Andreas Savelsbergh; Wolfgang Wintermeyer
Dynamics of translation on the ribosome: molecular mechanics of translocation.
FEMS microbiology reviews 1999;23(3):317-33.
1998: T Pape; Wolfgang Wintermeyer; Marina V Rodnina
Complete kinetic mechanism of elongation factor Tu-dependent binding of aminoacyl-tRNA to the A site of the E. coli ribosome.
The EMBO journal 1998;17(24):7490-7.
1998: JR Jagath; Marina V Rodnina; Georg Lentzen; Wolfgang Wintermeyer
Interaction of guanine nucleotides with the signal recognition particle from Escherichia coli.
Biochemistry 1998;37(44):15408-13.
1998: Marina V Rodnina; Wolfgang Wintermeyer
Form follows function: structure of an elongation factor G-ribosome complex.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7237-9.
1998: QA Valent; Pier A Scotti; Stephen High; Jan-Willem de Gier; Gunnar von Heijne; Georg Lentzen; Wolfgang Wintermeyer; Bauke Oudega; Joen Luirink
The Escherichia coli SRP and SecB targeting pathways converge at the translocon.
The EMBO journal 1998;17(9):2504-12.
1997: Holger Stark; Marina V Rodnina; Jutta Rinke-Appel; Richard Brimacombe; Wolfgang Wintermeyer; Marin van Heel
Visualization of elongation factor Tu on the Escherichia coli ribosome.
Nature 1997;389(6649):403-6.
1997: Holger Stark; Elena V Orlova; Jutta Rinke-Appel; N Jünke; Florian Mueller; Marina V Rodnina; Wolfgang Wintermeyer; Richard Brimacombe; Marin van Heel
Arrangement of tRNAs in pre- and posttranslocational ribosomes revealed by electron cryomicroscopy.
Cell 1997;88(1):19-28.
1997: Marina V Rodnina; Andreas Savelsbergh; Vladimir I Katunin; Wolfgang Wintermeyer
Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome.
Nature 1997;385(6611):37-41.
1996: E Vorstenbosch; T Pape; Marina V Rodnina; Barend Kraal; Wolfgang Wintermeyer
The G222D mutation in elongation factor Tu inhibits the codon-induced conformational changes leading to GTPase activation on the ribosome.
The EMBO journal 1996;15(23):6766-74.
1996: Y P Semenkov; Marina V Rodnina; Wolfgang Wintermeyer
The "allosteric three-site model" of elongation cannot be confirmed in a well-defined ribosome system from Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12183-8.
1996: C Borowski; Marina V Rodnina; Wolfgang Wintermeyer
Truncated elongation factor G lacking the G domain promotes translocation of the 3' end but not of the anticodon domain of peptidyl-tRNA.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4202-6.
1996: Georg Lentzen; H Moine; C Ehresmann; B Ehresmann; Wolfgang Wintermeyer
Structure of 4.5S RNA in the signal recognition particle of Escherichia coli as studied by enzymatic and chemical probing.
RNA (New York, N.Y.) 1996;2(3):244-53.
1996: Marina V Rodnina; T Pape; R Fricke; L Kuhn; Wolfgang Wintermeyer
Initial binding of the elongation factor Tu.GTP.aminoacyl-tRNA complex preceding codon recognition on the ribosome.
The Journal of biological chemistry 1996;271(2):646-52.
1995: Marina V Rodnina; T Pape; R Fricke; Wolfgang Wintermeyer
Elongation factor Tu, a GTPase triggered by codon recognition on the ribosome: mechanism and GTP consumption.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1995;73(11-12):1221-7.
1995: R Kusters; Georg Lentzen; E Eppens; A van Geel; C C van der Weijden; Wolfgang Wintermeyer; Joen Luirink
The functioning of the SRP receptor FtsY in protein-targeting in E. coli is correlated with its ability to bind and hydrolyse GTP.
FEBS letters 1995;372(2-3):253-8.
1995: Marina V Rodnina; R Fricke; L Kuhn; Wolfgang Wintermeyer
Codon-dependent conformational change of elongation factor Tu preceding GTP hydrolysis on the ribosome.
The EMBO journal 1995;14(11):2613-9.
1995: W Zeidler; C Egle; S Ribeiro; A Wagner; Vladimir I Katunin; R Kreutzer; Marina V Rodnina; Wolfgang Wintermeyer; Mathias Sprinzl
Site-directed mutagenesis of Thermus thermophilus elongation factor Tu. Replacement of His85, Asp81 and Arg300.
European journal of biochemistry / FEBS 1995;229(3):596-604.
1995: Marina V Rodnina; Wolfgang Wintermeyer
GTP consumption of elongation factor Tu during translation of heteropolymeric mRNAs.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):1945-9.
1994: Marina V Rodnina; R Fricke; Wolfgang Wintermeyer
Transient conformational states of aminoacyl-tRNA during ribosome binding catalyzed by elongation factor Tu.
Biochemistry 1994;33(40):12267-75.
1994: Georg Lentzen; B Dobberstein; Wolfgang Wintermeyer
Formation of SRP-like particle induces a conformational change in E. coli 4.5S RNA.
FEBS letters 1994;348(3):233-8.
1994: Marina V Rodnina; Y P Semenkov; Wolfgang Wintermeyer
Purification of fMet-tRNA(fMet) by fast protein liquid chromatography.
Analytical biochemistry 1994;219(2):380-1.
1992: Marina V Rodnina; Wolfgang Wintermeyer
Two tRNA-binding sites in addition to A and P sites on eukaryotic ribosomes.
Journal of molecular biology 1992;228(2):450-9.
1989: Roland Lill; J M Robertson; Wolfgang Wintermeyer
Binding of the 3' terminus of tRNA to 23S rRNA in the ribosomal exit site actively promotes translocation.
The EMBO journal 1989;8(12):3933-8.
1988: Roland Lill; A Lepier; F Schwägele; M Sprinzl; H Vogt; Wolfgang Wintermeyer
Specific recognition of the 3'-terminal adenosine of tRNAPhe in the exit site of Escherichia coli ribosomes.
Journal of molecular biology 1988;203(3):699-705.
1988: Roland Lill; Wolfgang Wintermeyer
Quantitative indicator assay of tRNA binding to the ribosomal P and A sites.
Methods in enzymology 1988;164():597-611.
1987: J M Robertson; Wolfgang Wintermeyer
Shielding of the D loop of ribosome-bound tRNA by elongation factor G.
Journal of molecular biology 1987;198(1):133-6.
1987: Roland Lill; Wolfgang Wintermeyer
Destabilization of codon-anticodon interaction in the ribosomal exit site.
Journal of molecular biology 1987;196(1):137-48.
1986: Roland Lill; J M Robertson; Wolfgang Wintermeyer
Affinities of tRNA binding sites of ribosomes from Escherichia coli.
Biochemistry 1986;25(11):3245-55.
1984: Roland Lill; J M Robertson; Wolfgang Wintermeyer
tRNA binding sites of ribosomes from Escherichia coli.
Biochemistry 1984;23(26):6710-7.