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Jean-Yves Winum

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Moufida Belfaragui; Achour Seridi; Jean-Yves Winum; Mohamed Abdaoui; Mekki Kadri
A spectrophotometric and thermodynamic study of the charge-transfer complexes of N-aryl-N'-isopropyloxycarbonylsulfamides with DDQ and TCNE.
Adeline Bonneau; Alfonso Maresca; Jean-Yves Winum; Claudiu T Supuran
Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors.
Jean-Yves Winum; Pedro A Colinas; Claudiu T Supuran
Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer.

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2013: Moufida Belfaragui; Achour Seridi; Jean-Yves Winum; Mohamed Abdaoui; Mekki Kadri
A spectrophotometric and thermodynamic study of the charge-transfer complexes of N-aryl-N'-isopropyloxycarbonylsulfamides with DDQ and TCNE.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2013;108():55-61.
2013: Adeline Bonneau; Alfonso Maresca; Jean-Yves Winum; Claudiu T Supuran
Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors.
Journal of enzyme inhibition and medicinal chemistry 2013;28(2):397-401.
2013: Jean-Yves Winum; Pedro A Colinas; Claudiu T Supuran
Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer.
Bioorganic & medicinal chemistry 2013;21(6):1419-26.
2013: Jean-Yves Winum; Clemente Capasso
Novel antibody to a carbonic anhydrase: patent evaluation of WO2011138279A1.
Expert opinion on therapeutic patents 2013;23(6):757-60.
2012: Jean-Yves Winum; Fabrizio Carta; Alfonso Maresca; Andrea Scozzafava; Claudiu T Supuran
Polypharmacology of sulfonamides: pazopanib, a multitargeted receptor tyrosine kinase inhibitor in clinical use, potently inhibits several mammalian carbonic anhydrases.
Chemical communications (Cambridge, England) 2012;48(66):8177-9.
2012: Katia D'Ambrosio; Giuseppina De Simone; Fatma-Zhora Smaine; Fabrizio Carta; Jean-Yves Winum; Claudiu T Supuran
Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups.
Journal of medicinal chemistry 2012;55(15):6776-83.
2012: Jean-Yves Winum; Carol Ward; Fabrizio Carta; Alessandro Cecchi; David Harrison; Ian Kunkler; Simon P Langdon; Peter Mullen; Andrea Scozzafava; Claudiu T Supuran
Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines.
Bioorganic & medicinal chemistry letters 2012;22(14):4681-5.
2012: Roben G Gieling; Lupti Mamnani; Andrea Scozzafava; Claudiu T Supuran; Brian A Telfer; Muhammad Babur; Natalie Burrows; Fabrizio Carta; Jean-Yves Winum; Kaye J Williams
Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.
Journal of medicinal chemistry 2012;55(11):5591-600.
2012: Marie Lopez; Stephan Köhler; Jean-Yves Winum
Zinc metalloenzymes as new targets against the bacterial pathogen Brucella.
Journal of inorganic biochemistry 2012;111():138-45.
2012: Gianfranco Balboni; Cenzo Congiu; Annalisa Maietti; Alfonso Maresca; Valentina Onnis; Andrea Scozzafava; Jean-Yves Winum; Claudiu T Supuran
Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins.
Bioorganic & medicinal chemistry letters 2012;22(9):3063-6.
2012: Alfonso Maresca; Andrea Scozzafava; Stephan Köhler; Jean-Yves Winum; Claudiu T Supuran
Inhibition of beta-carbonic anhydrases from the bacterial pathogen Brucella suis with inorganic anions.
Journal of inorganic biochemistry 2012;110():36-9.
2012: Paul C McDonald; Claudiu T Supuran; Jean-Yves Winum; Shoukat Dedhar
Recent developments in targeting carbonic anhydrase IX for cancer therapeutics.
Oncotarget 2012;3(1):84-97.
2011: Marouan Rami; Andrea Scozzafava; Alessio Innocenti; Jean-Louis Montero; Jean-Yves Winum; Claudiu T Supuran
Synthesis of rhodamine B-benzenesulfonamide conjugates and their inhibitory activity against human α- and bacterial/fungal β-carbonic anhydrases.
Bioorganic & medicinal chemistry letters 2011;21(18):5210-3.
2011: Mohamed-Chiheb Saada; Andrea Scozzafava; Daniela Vullo; Jean-Yves Winum; Jean-Louis Montero; Claudiu T Supuran
Carbonic anhydrase I and II activation with mono- and dihalogenated histamine derivatives.
Bioorganic & medicinal chemistry letters 2011;21(16):4884-7.
2011: Marie-Rose Abdo; Pascale Joseph; Jérémie Mortier; François Turtaut; Jean-Louis Montero; Bernard Masereel; Stephan Köhler; Jean-Yves Winum
Anti-virulence strategy against Brucella suis: synthesis, biological evaluation and molecular modeling of selective histidinol dehydrogenase inhibitors.
Organic & biomolecular chemistry 2011;9(10):3681-90.
2011: Marouan Rami; Alfonso Maresca; Fatma-Zhora Smaine; Jean-Louis Montero; Andrea Scozzafava; Jean-Yves Winum; Claudiu T Supuran
Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII.
Bioorganic & medicinal chemistry letters 2011;21(10):2975-9.
2011: Yuanmei Lou; Paul C McDonald; Andrew Minchinton; Arusha Oloumi; Christina Ostlund; Christopher M Overall; Fabio Pacchiano; Calvin Roskelley; Andrea Scozzafava; Claudiu T Supuran; Brent W Sutherland; Nadia Touisni; Dawn Waterhouse; Jean-Yves Winum; Ardalan Ahmadi; Ulrich auf dem Keller; Marcel Bally; Fabrizio Carta; Stephen Chia; Blaise Clarke; David Huntsman; Alastair Kyle; Samuel Leung; Shoukat Dedhar
Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.
Cancer research 2011;71(9):3364-76.
2011: Mohamed-Chiheb Saada; Jean-Louis Montero; Daniela Vullo; Andrea Scozzafava; Jean-Yves Winum; Claudiu T Supuran
Carbonic anhydrase activators: gold nanoparticles coated with derivatized histamine, histidine, and carnosine show enhanced activatory effects on several mammalian isoforms.
Journal of medicinal chemistry 2011;54(5):1170-7.
2011: Pascale Joseph; Safia Ouahrani-Bettache; Jean-Louis Montero; Isao Nishimori; Tomoko Minakuchi; Daniela Vullo; Andrea Scozzafava; Jean-Yves Winum; Stephan Köhler; Claudiu T Supuran
A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.
Bioorganic & medicinal chemistry 2011;19(3):1172-8.
2010: Anna Di Fiore; Simona Maria Monti; Alessio Innocenti; Jean-Yves Winum; Giuseppina De simone; Claudiu T Supuran
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
Bioorganic & medicinal chemistry letters 2010;20(12):3601-5.
2010: Daniela Vullo; Isao Nishimori; Andrea Scozzafava; Stephan Köhler; Jean-Yves Winum; Claudiu T Supuran
Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.
Bioorganic & medicinal chemistry letters 2010;20(7):2178-82.
2010: Pascale Joseph; François Turtaut; Safia Ouahrani-Bettache; Jean-Louis Montero; Isao Nishimori; Tomoko Minakuchi; Daniela Vullo; Andrea Scozzafava; Stephan Köhler; Jean-Yves Winum; Claudiu T Supuran
Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.
Journal of medicinal chemistry 2010;53(5):2277-85.
2010: Jean-Yves Winum; Stephan Köhler; Claudiu T Supuran
Brucella carbonic anhydrases: new targets for designing anti-infective agents.
Current pharmaceutical design 2010;16(29):3310-6.
2009: Jean-Yves Winum; Jean-Louis Montero; Daniela Vullo; Claudiu T Supuran
Carbonic anhydrase inhibitors: glycosylsulfanilamides act as subnanomolar inhibitors of the human secreted isoform VI.
Chemical biology & drug design 2009;74(6):636-9.
2009: Gihane Nasr; Eddy Petit; Claudiu T Supuran; Jean-Yves Winum; Mihail Barboiu
Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases.
Bioorganic & medicinal chemistry letters 2009;19(21):6014-7.
2009: Rosa Maria Vitale; vincenzo alterio; Alessio Innocenti; Jean-Yves Winum; Simona Maria Monti; Giuseppina De Simone; Claudiu T Supuran
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.
Journal of medicinal chemistry 2009;52(19):5990-8.
2009: Jean-Yves Winum; Alessio Innocenti; Daniela Vullo; Jean-Louis Montero; Claudiu T Supuran
Carbonic anhydrase inhibitors; fluorinated phenyl sulfamates show strong inhibitory activity and selectivity for the inhibition of the tumor-associated isozymes IX and XII over the cytosolic ones I and II.
Bioorganic & medicinal chemistry letters 2009;19(17):5082-5.
2009: Gihane Nasr; Eddy Petit; Daniela Vullo; Jean-Yves Winum; Claudiu T Supuran; Mihail Barboiu
Carbonic anhydrase-encoded dynamic constitutional libraries: toward the discovery of isozyme-specific inhibitors.
Journal of medicinal chemistry 2009;52(15):4853-9.
2009: Jean-Yves Winum; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
Inhibition of carbonic anhydrase IX: a new strategy against cancer.
Anti-cancer agents in medicinal chemistry 2009;9(6):693-702.
2009: Jean-Yves Winum; Alessio Innocenti; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isoforms I and II and transmembrane, tumor-associated isoforms IX and XII with boronic acids.
Bioorganic & medicinal chemistry 2009;17(10):3649-52.
2009: Alessio Innocenti; Jean-Yves Winum; Rebecca A Hall; Fritz A Mühlschlegel; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Bioorganic & medicinal chemistry letters 2009;19(10):2642-5.
2009: Marie-Rose Abdo; Daniela Vullo; Mohamed-Chiheb Saada; Jean-Louis Montero; Andrea Scozzafava; Jean-Yves Winum; Claudiu T Supuran
Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido l-histidine derivatives.
Bioorganic & medicinal chemistry letters 2009;19(9):2440-3.
2009: Jean-Yves Winum; Sally-Ann Poulsen; Claudiu T Supuran
Therapeutic applications of glycosidic carbonic anhydrase inhibitors.
Medicinal research reviews 2009;29(3):419-35.
2009: Achour Seridi; Hocine Akkari; Jean-Yves Winum; Patricia Bénard-Rocherullé; Mohamed Abdaoui
tert-Butyl N-[N,N-bis-(2-chloro-ethyl)sulfamo-yl]-N-(2-chloro-ethyl)carbamate.
Acta crystallographica. Section E, Structure reports online 2009;65(Pt 10):o2543-4.
2008: Fatma-Zohra Smaine; Fabio Pacchiano; Marouan Rami; Véronique Barragan-Montero; Daniela Vullo; Andrea Scozzafava; Jean-Yves Winum; Claudiu T Supuran
Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.
Bioorganic & medicinal chemistry letters 2008;18(24):6332-5.
2008: Maamar Stiti; Alessandro Cecchi; Marouan Rami; Mohamed Abdaoui; Véronique Barragan-Montero; Andrea Scozzafava; Yannick Guari; Jean-Yves Winum; Claudiu T Supuran
Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II.
Journal of the American Chemical Society 2008;130(48):16130-1.
2008: Marouan Rami; Alessandro Cecchi; Jean-Louis Montero; Alessio Innocenti; Daniela Vullo; Andrea Scozzafava; Jean-Yves Winum; Claudiu T Supuran
Carbonic anhydrase inhibitors: design of membrane-impermeant copper(II) complexes of DTPA-, DOTA-, and TETA-tailed sulfonamides targeting the tumor-associated transmembrane isoform IX.
ChemMedChem 2008;3(11):1780-8.
2008: Alessandro Cecchi; Laura Ciani; Jean-Yves Winum; Jean-Louis Montero; Andrea Scozzafava; Sandra Ristori; Claudiu T Supuran
Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.
Bioorganic & medicinal chemistry letters 2008;18(12):3475-80.
2008: Marie-Rose Abdo; Pascale Joseph; Rose-Anne Boigegrain; Jean-Louis Montero; Stephan Köhler; Jean-Yves Winum
Brucella suis histidinol dehydrogenase: synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide.
Journal of enzyme inhibition and medicinal chemistry 2008;23(3):357-61.
2008: Jean-Yves Winum; Marouan Rami; Andrea Scozzafava; Jean-Louis Montero; Claudiu Supuran
Carbonic anhydrase IX: a new druggable target for the design of antitumor agents.
Medicinal research reviews 2008;28(3):445-63.
2008: Marouan Rami; Jean-Yves Winum; Alessio Innocenti; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.
Bioorganic & medicinal chemistry letters 2008;18(2):836-41.
2008: Jean-Yves Winum; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
Design of zinc binding functions for carbonic anhydrase inhibitors.
Current pharmaceutical design 2008;14(7):615-21.
2007: Pascale Joseph; Marie-Rose Abdo; Rose-Anne Boigegrain; Jean-Louis Montero; Jean-Yves Winum; Stephan Köhler
Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen.
Antimicrobial agents and chemotherapy 2007;51(10):3752-5.
2007: Fatma-Zohra Smaine; Jean-Yves Winum; Jean-Louis Montero; Zine Regainia; Daniela Vullo; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides.
Bioorganic & medicinal chemistry letters 2007;17(18):5096-100.
2007: Marie-Rose Abdo; Pascale Joseph; Rose-Anne Boigegrain; Jean-Pierre Liautard; Jean-Louis Montero; Stephan Köhler; Jean-Yves Winum
Brucella suis histidinol dehydrogenase: synthesis and inhibition studies of a series of substituted benzylic ketones derived from histidine.
Bioorganic & medicinal chemistry 2007;15(13):4427-33.
2007: Mounir Nessaiba; Mohamed Abdaoui; Abed El Ghani Djahoudi; Mekki Kadri; Jean-Yves Winum
Synthesis of substituted N-aryl-N'-Sulfamoyloxazolidin-2-ones with potential antibacterial activity.
Recent patents on anti-infective drug discovery 2007;2(2):131-9.
2007: Jean-Yves Winum; Anne Thiry; Khaled El Cheikh; Jean-Michel Dogné; Jean-Louis Montero; Daniela Vullo; Andrea Scozzafava; Bernard Masereel; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.
Bioorganic & medicinal chemistry letters 2007;17(10):2685-91.
2007: Claudia Temperini; Jean-Yves Winum; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(10):2795-801.
2007: Anna Di Fiore; Andrea Scozzafava; Jean-Yves Winum; Jean-Louis Montero; Carlo Pedone; Claudiu T Supuran; Giuseppina De simone
Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties.
Bioorganic & medicinal chemistry letters 2007;17(6):1726-31.
2007: Jean-Yves Winum; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
Metal binding functions in the design of carbonic anhydrase inhibitors.
Current topics in medicinal chemistry 2007;7(9):835-48.
2006: Jean-Yves Winum; Claudia Temperini; Khaled El Cheikh; Alessio Innocenti; Daniela Vullo; Samuele Ciattini; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.
Journal of medicinal chemistry 2006;49(24):7024-31.
2006: Jean-Yves Winum; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
Therapeutic potential of sulfamides as enzyme inhibitors.
Medicinal research reviews 2006;26(6):767-92.
2006: Giuseppina De simone; Rosa Maria Vitale; Anna Di Fiore; Carlo Pedone; Andrea Scozzafava; Jean-Louis Montero; Jean-Yves Winum; Claudiu T Supuran
Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.
Journal of medicinal chemistry 2006;49(18):5544-51.
2006: Achour Seridi; Jean-Yves Winum; Mekki Kadri; Mohamed Abdaoui; Jean-Louis Montero
Study on the decomposition of 2-chloroethylnitro- sosulfamides (CENS) in serum using HPLC on-line solid phase extraction.
Archiv der Pharmazie 2006;339(9):521-6.
2006: Jean-Yves Winum; Alessandro Cecchi; Achour Seridi; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
Carbonic anhydrase inhibitors. N-cyanomethylsulfonamides--a new zinc binding group in the design of inhibitors targeting cytosolic and membrane-anchored isoforms.
Journal of enzyme inhibition and medicinal chemistry 2006;21(4):477-81.
2006: Jean-Yves Winum; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
New zinc binding motifs in the design of selective carbonic anhydrase inhibitors.
Mini reviews in medicinal chemistry 2006;6(8):921-36.
2006: Julien Hanson; Denis Reynaud; Na Qiao; Philippe Devel; Anne-Lise Moray; Jean-François Renard; Leanne P Kelley; Jean-Yves Winum; Jean-Louis Montero; B Therese Kinsella; Bernard Pirotte; Cecil R Pace-Asciak; Jean-Michel Dogné
Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor.
Journal of medicinal chemistry 2006;49(12):3701-9.
2006: Achour Seridi; Mekki Kadri; Mohamed Abdaoui; Jean-Yves Winum; Jean-Louis Montero
Kinetic investigation on aqueous decomposition of 2-chloroethylnitrososulfamide.
Bioorganic & medicinal chemistry letters 2006;16(4):1021-7.
2006: Jean-Yves Winum; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
The sulfamide motif in the design of enzyme inhibitors.
Expert opinion on therapeutic patents 2006;16(1):27-47.
2005: Véronique Barragan-Montero; Jean-Yves Winum; Jean-Pierre Molès; Emmanuelle Juan; Caroline Clavel; Jean-Louis Montero
Synthesis and properties of isocannabinoid and cholesterol derivatized rhamnosurfactants: application to liposomal targeting of keratinocytes and skin.
European journal of medicinal chemistry 2005;40(10):1022-9.
2005: Alessandro Cecchi; Alzbeta Hulikova; Jaromir Pastorek; Silvia Pastoreková; Andrea Scozzafava; Jean-Yves Winum; Jean-Louis Montero; Claudiu T Supuran
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.
Journal of medicinal chemistry 2005;48(15):4834-41.
2005: Jean-Yves Winum; Alessandro Cecchi; Jean-Louis Montero; Alessio Innocenti; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumors.
Bioorganic & medicinal chemistry letters 2005;15(13):3302-6.
2005: Vladimir Garaj; Luca Puccetti; Giuseppe Fasolis; Jean-Yves Winum; Jean-Louis Montero; Andrea Scozzafava; Daniela Vullo; Alessio Innocenti; Claudiu T Supuran
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.
Bioorganic & medicinal chemistry letters 2005;15(12):3102-8.
2005: Luca Puccetti; Giuseppe Fasolis; Alessandro Cecchi; Jean-Yves Winum; Alessandro Gamberi; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.
Bioorganic & medicinal chemistry letters 2005;15(9):2359-64.
2005: Jean-Yves Winum; Alessio Innocenti; Jihane Nasr; Jean-Louis Montero; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(9):2353-8.
2005: Jean-Yves Winum; Jean-Michel Dogné; Angela Casini; Xavier de Leval; Jean-Louis Montero; Andrea Scozzafava; Daniela Vullo; Alessio Innocenti; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties.
Journal of medicinal chemistry 2005;48(6):2121-5.
2005: Jean-Yves Winum; Alessio Innocenti; Valérie Gagnard; Jean-Louis Montero; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates.
Bioorganic & medicinal chemistry letters 2005;15(6):1683-6.
2005: Jean-Yves Winum; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
Sulfamates and their therapeutic potential.
Medicinal research reviews 2005;25(2):186-228.
2005: Mekki Kadri; Rayenne Djemil; Mohamed Abdaoui; Jean-Yves Winum; Frédéric Coutrot; Jean-Louis Montero
Inclusion complexes of N-sulfamoyloxazolidinones with beta-cyclodextrin.
Bioorganic & medicinal chemistry letters 2005;15(4):889-94.
2005: Jean-Yves Winum; Silvia Pastorekova; Lydia Jakubickova; Jean-Louis Montero; Andrea Scozzafava; Jaromir Pastorek; Daniela Vullo; Alessio Innocenti; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.
Bioorganic & medicinal chemistry letters 2005;15(3):579-84.
2004: Fabien Julémont; Xavier de Leval; Catherine Michaux; Jean-François Renard; Jean-Yves Winum; Jean-Louis Montero; Jacques Damas; Jean-Michel Dogné; Bernard Pirotte
Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors.
Journal of medicinal chemistry 2004;47(27):6749-59.
2004: Alessandro Cecchi; Jean-Yves Winum; Alessio Innocenti; Daniela Vullo; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.
Bioorganic & medicinal chemistry letters 2004;14(23):5775-80.
2004: Vladimir Garaj; Luca Puccetti; Giuseppe Fasolis; Jean-Yves Winum; Jean-Louis Montero; Andrea Scozzafava; Daniela Vullo; Alessio Innocenti; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.
Bioorganic & medicinal chemistry letters 2004;14(21):5427-33.
2004: Laurent Bonnac; Alessio Innocenti; Jean-Yves Winum; Angela Casini; Jean-Louis Montero; Andrea Scozzafava; Veronique Barragan; Claudiu T Supuran
Carbonic anhydrase inhibitors: aliphatic N-phosphorylated sulfamates--a novel zinc-anchoring group leading to nanomolar inhibitors.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):275-8.
2004: Francesco Abbate; Jean-Yves Winum; Barry V L Potter; Angela Casini; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.
Bioorganic & medicinal chemistry letters 2004;14(1):231-4.
2004: Jean-Yves Winum; Angela Casini; Francesco Mincione; Michele Starnotti; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.
Bioorganic & medicinal chemistry letters 2004;14(1):225-9.
2004: Mekki Kadri; Nabila Dhaoui; Mohamed Abdaoui; Jean-Yves Winum; Jean-Louis Montero
Inclusion complexes of 2-chloroethylnitrososulfamides (CENS) with beta-cyclodextrin.
European journal of medicinal chemistry 2004;39(1):79-84.
2003: Jean-Yves Winum; Daniela Vullo; Angela Casini; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.
Journal of medicinal chemistry 2003;46(25):5471-7.
2003: Isabelle Passagne; Alexandre Evrard; Jean-Yves Winum; Philippe Depeille; Pierre Cuq; Jean-Louis Montero; Didier Cupissol; Laurence Vian
Cytotoxicity, DNA damage, and apoptosis induced by new fotemustine analogs on human melanoma cells in relation to O6-methylguanine DNA-methyltransferase expression.
The Journal of pharmacology and experimental therapeutics 2003;307(2):816-23.
2003: Jean-Yves Winum; Daniela Vullo; Angela Casini; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.
Journal of medicinal chemistry 2003;46(11):2197-204.
2003: Angela Casini; Jean-Yves Winum; Jean-Louis Montero; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.
Bioorganic & medicinal chemistry letters 2003;13(5):837-40.
2003: Jean-Yves Winum; Jean Luc Bouissière; Isabelle Passagne; Alexandre Evrard; Véronique Montero; Pierre Cuq; Jean-Louis Montero
Synthesis and biological evaluation of Fotemustine analogues on human melanoma cell lines.
European journal of medicinal chemistry 2003;38(3):319-24.
2002: Jean-Yves Winum; Stephen Baghdiguian; Thérèse Commes; Alain Leydet; Jean-Louis Montero
Synthesis of new Targretin analogues that induce apoptosis in leukemia HL-60 cells.
Bioorganic & medicinal chemistry letters 2002;12(24):3529-32.
2001: Jean-Yves Winum; Loïc Toupet; V Barragan; Georges Dewynter; Jean-Louis Montero
N-(tert-butoxycarbonyl)-N-[4-(dimethylazaniumylidene)-1,4-dihydropyridin-1-ylsulfonyl]azanide: a new sulfamyolating agent. Structure and reactivity toward amines.
Organic letters 2001;3(14):2241-3.
2001: Jean-Yves Winum; Alain Leydet; Michel Seman; Jean-Louis Montero
Synthesis and biological activity of glycosyl conjugates of N-(4-hydroxyphenyl)retinamide.
Farmaco (Società chimica italiana : 1989) 2001;56(4):319-24.
1997: Jean-Yves Winum; M Kamal; H Defacque; Thérèse Commes; C Chavis; M Lucas; Jacques Marti; Jean-Louis Montero
Synthesis and biological activities of higher homologues of retinoic acid.
Farmaco (Società chimica italiana : 1989) 1997;52(1):39-42.