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Dyann Wirth

Research Profile

Disorders

Falciparum Malaria

Chemicals & Drugs

Concepts & Ideas

Molecular Sequence Data

Genes & Molecular Sequences

Physiology

Geographic Areas

Senegal

Procedures

Phenomena

Nucleic Acid Hybridization

Co-author Network

Publications

TOP 3
Rachel Daniels; Elizabeth J Hamilton; Daniel L Hartl; Amanda K Lukens; Souleymane MBoup; Daouda Ndiaye; Daniel E Neafsey; Danny C Park; Pardis C Sabeti; Stephen F Schaffner; Papa Diogoye Séne; Daria Van Tyne; Hsiao-Han Chang; Dyann F Wirth; Sarah K Volkman
Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal.
Bradley I Coleman; Amy K Bei; Micah Manary; Ulf Ribacke; Elizabeth A Winzeler; Dyann F Wirth; Manoj T Duraisingh
Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene.
Hsiao-Han Chang; Kevin J Galinsky; Souleymane MBoup; Daouda Ndiaye; Omar Ndir; Daniel E Neafsey; Daniel J Park; Pardis C Sabeti; Stephen F Schaffner; Sarah K Volkman; Roger C Wiegand; Dyann F Wirth; Daniel L Hartl
Genomic sequencing of Plasmodium falciparum malaria parasites from Senegal reveals the demographic history of the population.

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All Publications

2013: Rachel Daniels; Elizabeth J Hamilton; Daniel L Hartl; Amanda K Lukens; Souleymane MBoup; Daouda Ndiaye; Daniel E Neafsey; Danny C Park; Pardis C Sabeti; Stephen F Schaffner; Papa Diogoye Séne; Daria Van Tyne; Hsiao-Han Chang; Dyann F Wirth; Sarah K Volkman
Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal.
PloS one 2013;8(4):e60780.
2012: Bradley I Coleman; Amy K Bei; Micah Manary; Ulf Ribacke; Elizabeth A Winzeler; Dyann F Wirth; Manoj T Duraisingh
Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene.
Cell host & microbe 2012;12(6):739-50.
2012: Hsiao-Han Chang; Kevin J Galinsky; Souleymane MBoup; Daouda Ndiaye; Omar Ndir; Daniel E Neafsey; Daniel J Park; Pardis C Sabeti; Stephen F Schaffner; Sarah K Volkman; Roger C Wiegand; Dyann F Wirth; Daniel L Hartl
Genomic sequencing of Plasmodium falciparum malaria parasites from Senegal reveals the demographic history of the population.
Molecular biology and evolution 2012;29(11):3427-39.
2012: Alfred Amambua-Ngwa; Kayla G Barnes; Amy K Bei; David J Conway; Amanda K Lukens; Daouda Ndiaye; Daniel E Neafsey; Daniel J Park; Papa Sene; Daria Van Tyne; Sarah K Volkman; Dyann F Wirth; Stephen F Schaffner
SNP genotyping identifies new signatures of selection in a deep sample of West African Plasmodium falciparum malaria parasites.
Molecular biology and evolution 2012;29(11):3249-53.
2012: Omar Ly; Souleymane MBoup; Dyann F Wirth; Ambroise D Ahouidi; Aida Sadikh Badiane; Amy K Bei; Awa Bineta Deme; Mouhamadou Diallo; Therese Dieng; Papa ElHadji Omar Gueye; Ousmane Sarr
Evolution of the pfcrt T76 and pfmdr1 Y86 markers and chloroquine susceptibility 8 years after cessation of chloroquine use in Pikine, Senegal.
Parasitology research 2012;111(4):1541-6.
2012: Daniel J Park; Ulf Ribacke; Pardis C Sabeti; Stephen F Schaffner; Clarissa Valim; Daria Van Tyne; Roger C Wiegand; Dyann F Wirth; Justin S Becker; Hsiao-Han Chang; Kevin Galinsky; Meghan Galligan; Daniel L Hartl; Amanda K Lukens; Souleymane MBoup; Daouda Ndiaye; Daniel E Neafsey; Sarah K Volkman
Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(32):13052-7.
2012: Carolina Bustamante; Onikepe A Folarin; Grace O Gbotosho; Elieth A Mesquita; Ayoade Oduola; Akintunde Sowunmi; Claudio José Struchiner; Amilcar Tanuri; Dyann F Wirth; Mariano G Zalis; Camila N Batista; Rodrigo M Brindeiro; Christian T Happi
In vitro-reduced susceptibility to artemether in P. falciparum and its association with polymorphisms on transporter genes.
The Journal of infectious diseases 2012;206(3):324-32.
2012: Rachel Daniels; Souleymane MBoup; Jason McKinney; Daouda Ndiaye; Pardis C Sabeti; Papa Diogoye Séne; Sarah K Volkman; Mikeal Wall; Dyann F Wirth
Rapid, field-deployable method for genotyping and discovery of single-nucleotide polymorphisms associated with drug resistance in Plasmodium falciparum.
Antimicrobial agents and chemotherapy 2012;56(6):2976-86.
2012: Sarah K Volkman; Daniel E Neafsey; Daniel J Park; Stephen F Schaffner; Dyann F Wirth
Harnessing genomics and genome biology to understand malaria biology.
Nature reviews. Genetics 2012;13(5):315-28.
2012: Tracy L Keller; Yeon-Jin Kim; Hak-Kyo Lee; Ralph Mazitschek; Anjana Rao; Mark S Sundrud; Joseph F Cortese; John David Dignam; Maja Edenius; Margaret Hendrick; Dyann F Wirth; Chang-Yeol Yeo; Jinah Yum; Davide Zocco; Malcolm Whitman
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.
Nature chemical biology 2012;8(3):311-7.
2012: Sarah K Volkman; Rachel F Daniels; Mahamadou DIAKITE; Daniel L Hartl; Ousmane A Koita; Donald J Krogstad; Marc A T Muskavitch; Daouda Ndiaye; Daniel E Neafsey; Davis Nwakanma; Daniel J Park; Pardis C Sabeti; Dyann F Wirth
Application of genomics to field investigations of malaria by the international centers of excellence for malaria research.
Acta tropica 2012;121(3):324-32.
2012: Danny A Milner; Malcolm E Molyneux; Jacqui Montgomery; Daniel E Neafsey; Daniel J Park; David M Rosen; Pardis C Sabeti; Stephen F Schaffner; Karl Boynton Seydel; Terrie E Taylor; Clarissa Valim; Jimmy Vareta; Sarah K Volkman; Roger C Wiegand; Kayla G Barnes; Rachel F Daniels; Simon J Glover; Steve Kamiza; Amanda K Lukens; Nira C Mahesh; Daria Van Tyne; Dyann F Wirth
Human cerebral malaria and Plasmodium falciparum genotypes in Malawi.
Malaria journal 2012;11():35.
2011: Jenny J Zhang; Michael Alifrangis; Priyanie H Amerasinghe; Rachel Daniels; Flemming Konradsen; Rupika Rajakaruna; Tharanga N Senaratne; Clarissa Valim; Dyann F Wirth; Nadira D Karunaweera
Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006.
The American journal of tropical medicine and hygiene 2011;85(5):811-4.
2011: Kathrin Buchholz; Thomas A Burke; Kim C Williamson; Roger C Wiegand; Dyann F Wirth; Matthias Marti
A high-throughput screen targeting malaria transmission stages opens new avenues for drug development.
The Journal of infectious diseases 2011;203(10):1445-53.
2011: Alexandre Melnikov; Daouda Ndiaye; Kayla G Barnes; Bruce Birren; James Bochicchio; Rachel Daniels; Timothy Fennell; Kevin Galinsky; Andreas Gnirke; Chad Nusbaum; Peter Rogov; Carsten Russ; Papa D Sene; Daria Van Tyne; Sarah K Volkman; Dyann F Wirth; Daniel E Neafsey
Hybrid selection for sequencing pathogen genomes from clinical samples.
Genome biology 2011;12(8):R73.
2010: Michael L Booker; Cecilia M Bastos; Martin L Kramer; Robert H Barker; Renato Skerlj; Amar Bir Sidhu; Xiaoyi Deng; Cassandra Celatka; Joseph F Cortese; Jose E Guerrero Bravo; Keila N Crespo Llado; Adelfa E Serrano; Iñigo Angulo-Barturen; María Belén Jiménez-Díaz; Sara Viera; Helen Garuti; Sergio Wittlin; Petros Papastogiannidis; Jing-Wen Lin; Chris J Janse; Shahid M Khan; Manoj Duraisingh; Bradley Coleman; Elizabeth J Goldsmith; Margaret A Phillips; Benito Munoz; Dyann F Wirth; Jeffrey D Klinger; Roger Wiegand; Edmund Sybertz
Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model.
The Journal of biological chemistry 2010;285(43):33054-64.
2010: Sameer Urgaonkar; Joseph F Cortese; Robert H Barker; Mandy Cromwell; Adelfa E Serrano; Dyann F Wirth; Jon Clardy; Ralph Mazitschek
A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity.
Organic letters 2010;12(18):3998-4001.
2010: Martine M Zilversmit; Sarah K Volkman; Mark A DePristo; Dyann F Wirth; Philip Awadalla; Daniel L Hartl
Low-complexity regions in Plasmodium falciparum: missing links in the evolution of an extreme genome.
Molecular biology and evolution 2010;27(9):2198-209.
2010: Sharmini Gunawardena; Nadira D Karunaweera; Marcelo U Ferreira; Myatt Phone-Kyaw; Richard J Pollack; Michael Alifrangis; Rupika S Rajakaruna; Flemming Konradsen; Priyanie H Amerasinghe; Mette L Schousboe; Gawrie N L Galappaththy; Rabindra R Abeyasinghe; Daniel L Hartl; Dyann F Wirth
Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia.
The American journal of tropical medicine and hygiene 2010;82(2):235-42.
2010: Daouda Ndiaye; Vishal Patel; Allison Demas; Michele LeRoux; Omar Ndir; Souleymane MBoup; Jon Clardy; Viswanathan Lakshmanan; Johanna Daily; Dyann F Wirth
A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials--increased sensitivity of P. falciparum to chloroquine in Senegal.
The American journal of tropical medicine and hygiene 2010;82(2):228-30.
2010: Pamela Orjuela-Sánchez; Nadira D Karunaweera; Mônica da Silva Nunes; Newton Soares da Silva; Kézia K G Scopel; Raquel M Gonçalves; Chanaki Amaratunga; Juliana Martha Sá; Duong Socheat; Rick M Fairhust; Sharmini Gunawardena; Thuraisamy Thavakodirasah; Gawrie L N Galapaththy; Rabindra Abeysinghe; Fumihiko Kawamoto; Dyann F Wirth; marcelo Urbano ferreira
Single-nucleotide polymorphism, linkage disequilibrium and geographic structure in the malaria parasite Plasmodium vivax: prospects for genome-wide association studies.
BMC genetics 2010;11():65.
2009: Margaret A Rush; Mary Lynn Baniecki; Ralph Mazitschek; Joseph F Cortese; Roger Wiegand; Jon Clardy; Dyann F Wirth
Colorimetric high-throughput screen for detection of heme crystallization inhibitors.
Antimicrobial agents and chemotherapy 2009;53(6):2564-8.
2009: Vishal Patel; Ralph Mazitschek; Bradley Coleman; Cokey Nguyen; Sameer Urgaonkar; Joseph Cortese; Robert H Barker; Edward Greenberg; Weiping Tang; James E Bradner; Stuart L Schreiber; Manoj T Duraisingh; Dyann F Wirth; Jon Clardy
Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.
Journal of medicinal chemistry 2009;52(8):2185-7.
2009: Jennifer S Sims; Kevin T Militello; Peter A Sims; Vishal P Patel; Jacob M Kasper; Dyann F Wirth
Patterns of gene-specific and total transcriptional activity during the Plasmodium falciparum intraerythrocytic developmental cycle.
Eukaryotic cell 2009;8(3):327-38.
2009: Christian T Happi; Grace O Gbotosho; Onikepe Folarin; Akintunde Sowunmi; T Hudson; M O'Neil; Wilbur K Milhous; Dyann F Wirth; A M J Oduola
Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria.
Antimicrobial agents and chemotherapy 2009;53(3):888-95.
2009: Carolyn K Dong; Vishal Patel; Jimmy C Yang; Jeffrey D Dvorin; Manoj T Duraisingh; Jon Clardy; Dyann F Wirth
Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(3):972-5.
2009: Neekesh V Dharia; Amar Bir Singh Sidhu; Maria Cassera; Scott J Westenberger; Selina Elisabeth Ruth Bopp; Richard Eastman; David Plouffe; Serge Batalov; Daniel J Park; Sarah K Volkman; Dyann F Wirth; Yingyao Zhou; Fidock David; Elizabeth A Winzeler
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum.
Genome biology 2009;10(2):R21.
2009: P M Lantos; A D Ahouidi; Amy K Bei; Cameron V Jennings; Ousmane Sarr; Omar Ndir; Dyann F Wirth; Souleymane MBoup; Manoj T Duraisingh
Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum.
Parasitology 2009;136(1):1-9.
2008: Vishal Patel; Michael Booker; Martin Kramer; Leila Ross; Cassandra A Celatka; Leah M Kennedy; Jeffrey D Dvorin; Manoj T Duraisingh; Piotr Sliz; Dyann F Wirth; Jon Clardy
Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.
The Journal of biological chemistry 2008;283(50):35078-85.
2008: Ousmane Sarr; Ambroise D Ahouidi; Omar Ly; Johanna Daily; Daouda Ndiaye; Omar Ndir; Souleymane MBoup; Dyann F Wirth
Mutations in PFCRT K76T do not correlate with sulfadoxine-pyrimethamine-amodiaquine failure in Pikine, Senegal.
Parasitology research 2008;103(4):765-9.
2008: Ralph Mazitschek; Vishal Patel; Dyann F Wirth; Jon Clardy
Development of a fluorescence polarization based assay for histone deacetylase ligand discovery.
Bioorganic & medicinal chemistry letters 2008;18(9):2809-12.
2008: Nadira D Karunaweera; Marcelo U Ferreira; Anusha Munasinghe; John W Barnwell; William E Collins; Christopher L King; Fumihiko Kawamoto; Daniel L Hartl; Dyann F Wirth
Extensive microsatellite diversity in the human malaria parasite Plasmodium vivax.
Gene 2008;410(1):105-12.
2008: Daniel E Neafsey; Stephen F Schaffner; Sarah K Volkman; Daniel Park; Philip Montgomery; Danny A Milner; Amanda Lukens; David Rosen; Rachel Daniels; Nathan Houde; Joseph F Cortese; Erin Tyndall; Casey Gates; Nicole Stange-Thomann; Ousmane Sarr; Daouda Ndiaye; Omar Ndir; Soulyemane Mboup; Marcelo U Ferreira; Sandra do Lago Moraes; Aditya P Dash; Chetan E Chitnis; Roger C Wiegand; Daniel L Hartl; Bruce W Birren; Eric S Lander; Pardis C Sabeti; Dyann F Wirth
Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence.
Genome biology 2008;9(12):R171.
2008: Rachel Daniels; Sarah K Volkman; Danny A Milner; Nira Mahesh; Daniel E Neafsey; Daniel J Park; David Rosen; Elaine Angelino; Pardis C Sabeti; Dyann F Wirth; Roger C Wiegand
A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking.
Malaria journal 2008;7():223.
2007: Johanna Daily; Daniel Scanfeld; N Pochet; Karine G Le Roch; David Plouffe; M Kamal; Ousmane Sarr; Souleymane MBoup; Omar Ndir; David Wypij; K Levasseur; E Thomas; Pablo Tamayo; C Dong; Yingyao Zhou; Eric S Lander; Daouda Ndiaye; Dyann F Wirth; Elizabeth A Winzeler; Jill P Mesirov; A Regev
Distinct physiological states of Plasmodium falciparum in malaria-infected patients.
Nature 2007;450(7172):1091-5.
2007: Lara Bethke; Susan Thomas; Kerone Walker; Ronak Lakhia; Radha Rangarajan; Dyann F Wirth
The role of DNA mismatch repair in generating genetic diversity and drug resistance in malaria parasites.
Molecular and biochemical parasitology 2007;155(1):18-25.
2007: Anusha M Gunasekera; Alissa Myrick; Karine G Le Roch; Elizabeth A Winzeler; Dyann F Wirth
Plasmodium falciparum: genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatment.
Experimental parasitology 2007;117(1):87-92.
2007: Cameron V Jennings; Ambroise D Ahouidi; Martine Zilversmit; Amy K Bei; Julian C Rayner; Ousmane Sarr; Omar Ndir; Dyann F Wirth; Souleymane MBoup; Manoj T Duraisingh
Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from Senegal.
Infection and immunity 2007;75(7):3531-8.
2007: Anusha M Gunasekera; Alissa Myrick; Kevin T Militello; Jennifer S Sims; Carolyn K Dong; Todd Gierahn; Karine G Le Roch; Elizabeth A Winzeler; Dyann F Wirth
Regulatory motifs uncovered among gene expression clusters in Plasmodium falciparum.
Molecular and biochemical parasitology 2007;153(1):19-30.
2007: Marcelo U Ferreira; Nadira D Karunaweera; Mônica da Silva Nunes; Natal S da Silva; Dyann F Wirth; Daniel L Hartl
Population structure and transmission dynamics of Plasmodium vivax in rural Amazonia.
The Journal of infectious diseases 2007;195(8):1218-26.
2007: Anusha M Gunasekera; Thilan Wickramarachchi; Daniel E Neafsey; Ishani Ganguli; Lakshman Perera; Prasad H Premaratne; Daniel Hartl; Shiroma M Handunnetti; Preethi V Udagama-Randeniya; Dyann F Wirth
Genetic diversity and selection at the Plasmodium vivax apical membrane antigen-1 (PvAMA-1) locus in a Sri Lankan population.
Molecular biology and evolution 2007;24(4):939-47.
2007: Mary Lynn Baniecki; Dyann F Wirth; Jon Clardy
High-throughput Plasmodium falciparum growth assay for malaria drug discovery.
Antimicrobial agents and chemotherapy 2007;51(2):716-23.
2007: Sarah K Volkman; Elena R Lozovsky; Alyssa Barry; Trevor B C Bedford; Lara Bethke; Alissa Myrick; Karen P Day; Daniel L Hartl; Dyann F Wirth; Stanley A Sawyer
Genomic heterogeneity in the density of noncoding single-nucleotide and microsatellite polymorphisms in Plasmodium falciparum.
Gene 2007;387(1-2):1-6.
2007: Sarah K Volkman; Pardis C Sabeti; David DeCaprio; Daniel E Neafsey; Stephen F Schaffner; Danny A Milner; Johanna Daily; Ousmane Sarr; Daouda Ndiaye; Omar Ndir; Souleymane MBoup; Manoj T Duraisingh; Amanda Lukens; Alan Derr; Nicole Stange-Thomann; Skye Waggoner; Robert Onofrio; Liuda Ziaugra; Evan Mauceli; Sante Gnerre; David B Jaffe; Joanne Zainoun; Roger C Wiegand; Bruce Birren; Daniel L Hartl; James E Galagan; Eric S Lander; Dyann F Wirth
A genome-wide map of diversity in Plasmodium falciparum.
Nature genetics 2007;39(1):113-9.
2006: Christian T Happi; Grace O Gbotosho; Onikepe Folarin; Akintunde Sowunmi; Olayinka M Bolaji; Babasola A Fateye; Dennis E Kyle; Wilbur K Milhous; Dyann F Wirth; Ayoade Oduola
Linkage disequilibrium between two distinct loci in chromosomes 5 and 7 of Plasmodium falciparum and in vivo chloroquine resistance in Southwest Nigeria.
Parasitology research 2006;100(1):141-8.
2006: Lara Bethke; Martine Zilversmit; Kaare Nielsen; Johanna Daily; Sarah K Volkman; Daouda Ndiaye; Elena R Lozovsky; Daniel L Hartl; Dyann F Wirth
Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum.
Molecular and biochemical parasitology 2006;150(1):10-24.
2006: Daouda Ndiaye; Johanna Daily; Ousmane Sarr; Omar Ndir; Oumar Gaye; Souleymane MBoup; Cally Roper; Dyann F Wirth
Defining the origin of Plasmodium falciparum resistant dhfr isolates in Senegal.
Acta tropica 2006;99(1):106-11.
2006: Christian T Happi; Grace O Gbotosho; Onikepe Folarin; Olayinka M Bolaji; Akintunde Sowunmi; Dennis E Kyle; Wilbur K Milhous; Dyann F Wirth; Ayoade Oduola
Association between mutations in Plasmodium falciparum chloroquine resistance transporter and P. falciparum multidrug resistance 1 genes and in vivo amodiaquine resistance in P. falciparum malaria-infected children in Nigeria.
The American journal of tropical medicine and hygiene 2006;75(1):155-61.
2006: Claire Kidgell; Sarah K Volkman; Johanna Daily; Justin O Borevitz; David Plouffe; Yingyao Zhou; Jeffrey R Johnson; Karine G Le Roch; Ousmane Sarr; Omar Ndir; Souleymane MBoup; Serge Batalov; Dyann F Wirth; Elizabeth A Winzeler
A systematic map of genetic variation in Plasmodium falciparum.
PLoS pathogens 2006;2(6):e57.
2006: Christian T Happi; Grace O Gbotosho; Onikepe Folarin; Danny Milner; Ousmane Sarr; Akintunde Sowunmi; Dennis E Kyle; Wilbur K Milhous; Dyann F Wirth; Ayoade Oduola
Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa.
Malaria journal 2006;5():82.
2005: Therese Dieng; IB Bah; Papa Ndiaye; I Diallo; Bernard M Diop; P Brasseur; Souleymane MBoup; Dyann F Wirth; Omar Ndir
[In vitro evaluation of the sensitivity of Plasmodium falciparum to chloroquine using the deli-microtest in region of Dakar, Senegal].
Médecine tropicale : revue du Corps de santé colonial 2005;65(6):580-3.
2005: Daouda Ndiaye; Johanna Daily; Ousmane Sarr; Omar Ndir; Oumar Gaye; Souleymane MBoup; Dyann F Wirth
Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Senegal.
Tropical medicine & international health : TM & IH 2005;10(11):1176-9.
2005: Deepa Jethwaney; Timothy Lepore; Saria Hassan; Kerrianne Mello; Radha Rangarajan; Willi Jahnen-Dechent; Dyann F Wirth; Ali A Sultan
Fetuin-A, a hepatocyte-specific protein that binds Plasmodium berghei thrombospondin-related adhesive protein: a potential role in infectivity.
Infection and immunity 2005;73(9):5883-91.
2005: Christian T Happi; Grace O Gbotosho; Onikepe Folarin; Dora O Akinboye; Bidemi O Yusuf; OO Ebong; Akintunde Sowunmi; Dennis E Kyle; Wilbur K Milhous; Dyann F Wirth; Ayoade Oduola
Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine-pyrimethamine resistance in malaria-infected patients from Nigeria.
Acta tropica 2005;95(3):183-93.
2005: Ousmane Sarr; Alissa Myrick; Johanna Daily; Bernard M Diop; Therese Dieng; Omar Ndir; Papa Salif Sow; Souleymane MBoup; Dyann F Wirth
In vivo and in vitro analysis of chloroquine resistance in Plasmodium falciparum isolates from Senegal.
Parasitology research 2005;97(2):136-40.
2005: Johanna Daily; Karine G Le Roch; Ousmane Sarr; Daouda Ndiaye; Amanda Lukens; Yingyao Zhou; Omar Ndir; Souleymane MBoup; Ali Sultan; Elizabeth A Winzeler; Dyann F Wirth
In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins.
The Journal of infectious diseases 2005;191(7):1196-203.
2005: Kevin T Militello; Vishal Patel; Anne-Danielle Chessler; Julia K Fisher; Jacob M Kasper; Anusha M Gunasekera; Dyann F Wirth
RNA polymerase II synthesizes antisense RNA in Plasmodium falciparum.
RNA (New York, N.Y.) 2005;11(4):365-70.
2005: Alissa Myrick; Ousmane Sarr; Therese Dieng; Omar Ndir; Souleymane MBoup; Dyann F Wirth
Analysis of the genetic diversity of the Plasmodium falciparum multidrug resistance gene 5' upstream region.
The American journal of tropical medicine and hygiene 2005;72(2):182-8.
2004: Lyndal R Emerson; B C Skillman; Hubert Wolfger; Karl Kuchler; Dyann F Wirth
The sensitivities of yeast strains deficient in PDR ABC transporters, to quinoline-ring antimalarial drugs.
Annals of tropical medicine and parasitology 2004;98(6):643-9.
2004: Johanna Daily; Karine G Le Roch; Ousmane Sarr; Xuemin Fang; Yingyao Zhou; Omar Ndir; Souleymane MBoup; Ali Sultan; Elizabeth A Winzeler; Dyann F Wirth
In vivo transcriptional profiling of Plasmodium falciparum.
Malaria journal 2004;3():30.
2004: Anusha M Gunasekera; Swati Patankar; Jonathan Schug; Geoffrey Eisen; Jessica Kissinger; David Roos; Dyann F Wirth
Widespread distribution of antisense transcripts in the Plasmodium falciparum genome.
Molecular and biochemical parasitology 2004;136(1):35-42.
2004: Matthew A Dodge; Ross F Waller; Larry M C Chow; Muhammad M Zaman; Leanne M Cotton; Malcolm J McConville; Dyann F Wirth
Localization and activity of multidrug resistance protein 1 in the secretory pathway of Leishmania parasites.
Molecular microbiology 2004;51(6):1563-75.
2004: Kevin T Militello; Matthew Dodge; Lara Bethke; Dyann F Wirth
Identification of regulatory elements in the Plasmodium falciparum genome.
Molecular and biochemical parasitology 2004;134(1):75-88.
2004: Christian T Happi; Grace O Gbotosho; Akintunde Sowunmi; Catherine O Falade; Dora O Akinboye; Lucia Gerena; Dennis E Kyle; Wilbur K Milhous; Dyann F Wirth; Ayoade Oduola
Molecular analysis of Plasmodium falciparum recrudescent malaria infections in children treated with chloroquine in Nigeria.
The American journal of tropical medicine and hygiene 2004;70(1):20-6.
2003: Anusha M Gunasekera; Swati Patankar; Jonathan Schug; Geoffrey Eisen; Dyann F Wirth
Drug-induced alterations in gene expression of the asexual blood forms of Plasmodium falciparum.
Molecular microbiology 2003;50(4):1229-39.
2003: Alissa Myrick; Anusha Munasinghe; Swati Patankar; Dyann F Wirth
Mapping of the Plasmodium falciparum multidrug resistance gene 5'-upstream region, and evidence of induction of transcript levels by antimalarial drugs in chloroquine sensitive parasites.
Molecular microbiology 2003;49(3):671-83.
2003: TC Happi; S M Thomas; Grace O Gbotosho; Catherine O Falade; Dora O Akinboye; Lucia Gerena; T Hudson; Akintunde Sowunmi; Dennis E Kyle; Wilbur K Milhous; Dyann F Wirth; Ayoade Oduola
Point mutations in the pfcrt and pfmdr-1 genes of Plasmodium falciparum and clinical response to chloroquine, among malaria patients from Nigeria.
Annals of tropical medicine and parasitology 2003;97(5):439-51.
2003: Connie S Chow; Dyann F Wirth
Linker scanning mutagenesis of the Plasmodium gallinaceum sexual stage specific gene pgs28 reveals a novel downstream cis-control element.
Molecular and biochemical parasitology 2003;129(2):199-208.
2003: Johanna Daily; C Roberts; Susan M Thomas; Omar Ndir; Therese Dieng; Souleymane MBoup; Dyann F Wirth
Prevalence of Plasmodium falciparum pfcrt polymorphisms and in vitro chloroquine sensitivity in Senegal.
Parasitology 2003;126(Pt 5):401-5.
2003: Kaare M Nielsen; Jacob Kasper; Mehee Choi; Trevor B C Bedford; Kurt Kristiansen; Dyann F Wirth; Sarah K Volkman; Elena R Lozovsky; Daniel L Hartl
Gene conversion as a source of nucleotide diversity in Plasmodium falciparum.
Molecular biology and evolution 2003;20(5):726-34.
2003: Kevin T Militello; Dyann F Wirth
A new reporter gene for transient transfection of Plasmodium falciparum.
Parasitology research 2003;89(2):154-7.
2002: Sarah K Volkman; Daniel L Hartl; Dyann F Wirth; Kaare M Nielsen; Mehee Choi; Serge Batalov; Yingyao Zhou; David Plouffe; Karine G Le Roch; Ruben Abagyan; Elizabeth A Winzeler
Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum.
Science (New York, N.Y.) 2002;298(5591):216-8.
2002: Dyann F Wirth
Biological revelations.
Nature 2002;419(6906):495-6.
2002: Daniel L Hartl; Sarah K Volkman; Kaare M Nielsen; Alyssa Barry; Karen P Day; Dyann F Wirth; Elizabeth A Winzeler
The paradoxical population genetics of Plasmodium falciparum.
Trends in parasitology 2002;18(6):266-72.
2002: Susan M Thomas; Omar Ndir; Therese Dieng; Souleymane MBoup; David Wypij; James H Maguire; Dyann F Wirth
In vitro chloroquine susceptibility and PCR analysis of pfcrt and pfmdr1 polymorphisms in Plasmodium falciparum isolates from Senegal.
The American journal of tropical medicine and hygiene 2002;66(5):474-80.
2002: Lyndal R Emerson; Martin E Nau; Rodger K Martin; Dennis E Kyle; Maryanne Vahey; Dyann F Wirth
Relationship between chloroquine toxicity and iron acquisition in Saccharomyces cerevisiae.
Antimicrobial agents and chemotherapy 2002;46(3):787-96.
2001: Swati Patankar; Anusha Munasinghe; A Shoaibi; L M Cummings; Dyann F Wirth
Serial analysis of gene expression in Plasmodium falciparum reveals the global expression profile of erythrocytic stages and the presence of anti-sense transcripts in the malarial parasite.
Molecular biology of the cell 2001;12(10):3114-25.
2001: Sarah K Volkman; Alyssa Barry; E J Lyons; Kaare M Nielsen; Susan M Thomas; Mehee Choi; S S Thakore; Karen P Day; Dyann F Wirth; Daniel L Hartl
Recent origin of Plasmodium falciparum from a single progenitor.
Science (New York, N.Y.) 2001;293(5529):482-4.
2001: WF Mbacham; C S Chow; Johanna Daily; Linnie M Golightly; Dyann F Wirth
Deletion analysis of the 5' flanking sequence of the Plasmodium gallinaceum sexual stage specific gene pgs28 suggests a bipartite arrangement of cis-control elements.
Molecular and biochemical parasitology 2001;113(1):183-7.
2001: Anusha Munasinghe; Swati Patankar; Brian P Cook; S L Madden; Rodger K Martin; Dennis E Kyle; A Shoaibi; L M Cummings; Dyann F Wirth
Serial analysis of gene expression (SAGE) in Plasmodium falciparum: application of the technique to A-T rich genomes.
Molecular and biochemical parasitology 2001;113(1):23-34.
2000: Swati Patankar; H Fujioka; Dyann F Wirth
The signal sequence and C-terminal hydrophobic domain are required for localization of the sexual stage antigen pgs28 to the surface of P. gallinaceum ookinetes.
Molecular and biochemical parasitology 2000;111(2):425-35.
2000: Martin E Nau; Lyndal R Emerson; Rodger K Martin; Dennis E Kyle; Dyann F Wirth; Maryanne Vahey
Technical assessment of the affymetrix yeast expression GeneChip YE6100 platform in a heterologous model of genes that confer resistance to antimalarial drugs in yeast.
Journal of clinical microbiology 2000;38(5):1901-8.
2000: Linnie M Golightly; WF Mbacham; Johanna Daily; Dyann F Wirth
3' UTR elements enhance expression of Pgs28, an ookinete protein of Plasmodium gallinaceum.
Molecular and biochemical parasitology 2000;105(1):61-70.
1999: KF Laserson; I Petralanda; R Almera; R H Barker; Andrew Spielman; James H Maguire; Dyann F Wirth
Genetic characterization of an epidemic of Plasmodium falciparum malaria among Yanomami Amerindians.
The Journal of infectious diseases 1999;180(6):2081-5.
1999: Margarita Saiz; Young Tae Ro; Dyann F Wirth; Jean L Patterson
Host cell proteins bind specifically to the capsid-cleaved 5' end of Leishmaniavirus RNA.
Journal of biochemistry 1999;126(3):538-44.
1999: Koen J Dechering; Anita M Kaan; WF Mbacham; Dyann F Wirth; Wijnand Eling; RN Konings; Hendrik G Stunnenberg
Isolation and functional characterization of two distinct sexual-stage-specific promoters of the human malaria parasite Plasmodium falciparum.
Molecular and cellular biology 1999;19(2):967-78.
1998: Margarita Saiz; Alejandro Llanos-Cuentas; Juan I Echevarria; Norma Roncal; Maria Cruz; M T Muniz; C Lucas; Dyann F Wirth; SM Scheffter; Allan Magill; Jean L Patterson
Short report: detection of Leishmaniavirus in human biopsy samples of leishmaniasis from Peru.
The American journal of tropical medicine and hygiene 1998;58(2):192-4.
1998: Sarah K Volkman; Dyann F Wirth
Functional analysis of pfmdr1 gene of Plasmodium falciparum.
Methods in enzymology 1998;292():174-81.
1997: Margaret E Perkins; Sarah K Volkman; Dyann F Wirth; Sylvie M Le Blancq
Characterization of an ATP-binding cassette transporter in Cryptosporidium parvum.
Molecular and biochemical parasitology 1997;87(1):117-22.
1995: Sarah K Volkman; Alan F Cowman; Dyann F Wirth
Functional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr1 gene of Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8921-5.
1994: A K Wong; M A Curotto de Lafaille; Dyann F Wirth
Identification of a cis-acting gene regulatory element from the lemdr1 locus of Leishmania enriettii.
The Journal of biological chemistry 1994;269(42):26497-502.
1994: R H Barker; T Banchongaksorn; J M Courval; wannapa suwonkerd; K Rimwungtragoon; Dyann F Wirth
Plasmodium falciparum and P. vivax: factors affecting sensitivity and specificity of PCR-based diagnosis of malaria.
Experimental parasitology 1994;79(1):41-9.
1994: A F Coutaux; J J Mooney; Dyann F Wirth
Neuronal monoamine reuptake inhibitors enhance in vitro susceptibility to chloroquine in resistant Plasmodium falciparum.
Antimicrobial agents and chemotherapy 1994;38(6):1419-21.
1994: A K Wong; L M Chow; Dyann F Wirth
A homologous recombination strategy to analyze the vinblastine resistance property of the V-circle in Leishmania.
Molecular and biochemical parasitology 1994;64(1):75-86.
1994: R H Barker; T Banchongaksorn; J M Courval; wannapa suwonkerd; K Rimwungtragoon; N Srittong; Dyann F Wirth
DNA probes as epidemiological tools for surveillance of Plasmodium falciparum malaria in Thailand.
International journal of epidemiology 1994;23(1):161-8.
1994: M G Zalis; C M Wilson; Y Zhang; Dyann F Wirth
Characterization of the pfmdr2 gene for Plasmodium falciparum.
Molecular and biochemical parasitology 1994;63(2):311.
1993: J F Tobin; Dyann F Wirth
Mutational analysis of a signal sequence required for protein secretion in Leishmania major.
Molecular and biochemical parasitology 1993;62(2):243-9.
1993: M G Zalis; C M Wilson; Y Zhang; Dyann F Wirth
Characterization of the pfmdr2 gene for Plasmodium falciparum.
Molecular and biochemical parasitology 1993;62(1):83-92.
1993: L M Chow; A K Wong; Buddy Ullman; Dyann F Wirth
Cloning and functional analysis of an extrachromosomally amplified multidrug resistance-like gene in Leishmania enriettii.
Molecular and biochemical parasitology 1993;60(2):195-208.
1993: J V Iralu; Venkataraman Sritharan; W S Pieciak; Dyann F Wirth; James H Maguire; R H Barker
Diagnosis of Mycobacterium avium bacteremia by polymerase chain reaction.
Journal of clinical microbiology 1993;31(7):1811-4.
1993: J F Tobin; Steven L Reiner; F Hatam; S Zheng; C L Leptak; Dyann F Wirth; Richard M Locksley
Transfected Leishmania expressing biologically active IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(11):5059-69.
1993: Sarah K Volkman; C M Wilson; Dyann F Wirth
Stage-specific transcripts of the Plasmodium falciparum pfmdr 1 gene.
Molecular and biochemical parasitology 1993;57(2):203-11.
1993: C M Wilson; Sarah K Volkman; Sodsri Thaithong; R K Martin; Dennis E Kyle; Wilbur K Milhous; Dyann F Wirth
Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand.
Molecular and biochemical parasitology 1993;57(1):151-60.
1993: A L Fontanet; D B Johnston; Alexander Walker; W Rooney; Krongthong Thimasarn; D Sturchler; M Macdonald; M Hours; Dyann F Wirth
High prevalence of mefloquine-resistant falciparum malaria in eastern Thailand.
Bulletin of the World Health Organization 1993;71(3-4):377-83.
1992: M A Curotto de Lafaille; Dyann F Wirth
Creation of Null/+ mutants of the alpha-tubulin gene in Leishmania enriettii by gene cluster deletion.
The Journal of biological chemistry 1992;267(33):23839-46.
1992: R H Barker; T Banchongaksorn; J M Courval; wannapa suwonkerd; K Rimwungtragoon; Dyann F Wirth
A simple method to detect Plasmodium falciparum directly from blood samples using the polymerase chain reaction.
The American journal of tropical medicine and hygiene 1992;46(4):416-26.
1992: M A Curotto de Lafaille; A Laban; Dyann F Wirth
Gene expression in Leishmania: analysis of essential 5' DNA sequences.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(7):2703-7.
1992: J F Tobin; Dyann F Wirth
A sequence insertion targeting vector for Leishmania enriettii.
The Journal of biological chemistry 1992;267(7):4752-8.
1991: J W Fries; R J Patel; W F Piessens; Dyann F Wirth
Detection of untreated mycobacteria by using polymerase chain reaction and specific DNA probes.
Journal of clinical microbiology 1991;29(8):1744-7.
1991: J F Tobin; A Laban; Dyann F Wirth
Homologous recombination in Leishmania enriettii.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):864-8.
1990: M R Rodgers; Stephen Popper; Dyann F Wirth
Amplification of kinetoplast DNA as a tool in the detection and diagnosis of Leishmania.
Experimental parasitology 1990;71(3):267-75.
1990: J W Fries; R J Patel; W F Piessens; Dyann F Wirth
Genus- and species-specific DNA probes to identify mycobacteria using the polymerase chain reaction.
Molecular and cellular probes 1990;4(2):87-105.
1990: R J Patel; J W Fries; W F Piessens; Dyann F Wirth
Sequence analysis and amplification by polymerase chain reaction of a cloned DNA fragment for identification of Mycobacterium tuberculosis.
Journal of clinical microbiology 1990;28(3):513-8.
1990: A Laban; J F Tobin; M A Curotto de Lafaille; Dyann F Wirth
Stable expression of the bacterial neor gene in Leishmania enriettii.
Nature 1990;343(6258):572-4.
1989: A Laban; Dyann F Wirth
Transfection of Leishmania enriettii and expression of chloramphenicol acetyltransferase gene.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9119-23.
1989: R H Barker; A D Brandling-Bennett; Davy K Koech; M Mugambi; B Khan; R David; J R David; Dyann F Wirth
Plasmodium falciparum: DNA probe diagnosis of malaria in Kenya.
Experimental parasitology 1989;69(3):226-33.
1989: J T Joseph; S M Aldritt; T Unnasch; O Puijalon; Dyann F Wirth
Characterization of a conserved extrachromosomal element isolated from the avian malarial parasite Plasmodium gallinaceum.
Molecular and cellular biology 1989;9(9):3621-9.
1989: S M Aldritt; J T Joseph; Dyann F Wirth
Sequence identification of cytochrome b in Plasmodium gallinaceum.
Molecular and cellular biology 1989;9(9):3614-20.
1989: R H Barker; L Suebsaeng; W Rooney; Dyann F Wirth
Detection of Plasmodium falciparum infection in human patients: a comparison of the DNA probe method to microscopic diagnosis.
The American journal of tropical medicine and hygiene 1989;41(3):266-72.
1989: S E Meredith; Thomas R Unnasch; M Karam; WF Piessens; Dyann F Wirth
Cloning and characterization of an Onchocerca volvulus specific DNA sequence.
Molecular and biochemical parasitology 1989;36(1):1-10.
1989: C M Wilson; A E Serrano; A Wasley; M P Bogenschutz; A H Shankar; Dyann F Wirth
Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.
Science (New York, N.Y.) 1989;244(4909):1184-6.
1989: R J Patel; W F Piessens; J R David; Dyann F Wirth
A cloned DNA fragment for identification of Mycobacterium tuberculosis.
Reviews of infectious diseases 1989;11 Suppl 2():S411-9.
1989: Dyann F Wirth; W O Rogers; R Barker; H Dourado; L Suesbang; B Albuquerque
Leishmaniasis and malaria: DNA probes for diagnosis and epidemiologic analysis.
Annals of the New York Academy of Sciences 1989;569():183-92.
1988: W O Rogers; P F Burnheim; Dyann F Wirth
Detection of Leishmania within sand flies by kinetoplast DNA hybridization.
The American journal of tropical medicine and hygiene 1988;39(5):434-9.
1988: W O Rogers; Dyann F Wirth
Generation of sequence diversity in the kinetoplast DNA minicircles of Leishmania mexicana amazonensis.
Molecular and biochemical parasitology 1988;30(1):1-8.
1988: S I Miller; Dyann F Wirth
trans splicing in Leishmania enriettii and identification of ribonucleoprotein complexes containing the spliced leader and U2 equivalent RNAs.
Molecular and cellular biology 1988;8(6):2597-603.
1987: J S Shah; M Karam; WF Piessens; Dyann F Wirth
Characterization of an Onchocerca-specific DNA clone from Onchocerca volvulus.
The American journal of tropical medicine and hygiene 1987;37(2):376-84.
1987: W O Rogers; Dyann F Wirth
Kinetoplast DNA minicircles: regions of extensive sequence divergence.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(2):565-9.
1986: Dyann F Wirth; W O Rogers; R Barker; H Dourado; L Suesebang; B Albuquerque
Leishmaniasis and malaria: new tools for epidemiologic analysis.
Science (New York, N.Y.) 1986;234(4779):975-9.
1986: J S Shah; L Lamontagne; T R Unnasch; Dyann F Wirth; WF Piessens
Characterization of a ribosomal DNA clone of Brugia malayi.
Molecular and biochemical parasitology 1986;19(1):67-75.
1986: R H Barker; L Suebsaeng; W Rooney; G C Alecrim; H V Dourado; Dyann F Wirth
Specific DNA probe for the diagnosis of Plasmodium falciparum malaria.
Science (New York, N.Y.) 1986;231(4744):1434-6.