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Ignacio Wistuba

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Erminia Massarelli; Heidi S Erickson; Faye M Johnson; Ignacio I Wistuba; Vassiliki A Papadimitrakopoulou
Uncommon Epidermal Growth Factor Receptor mutations in non-small cell lung cancer and their mechanisms of EGFR tyrosine kinase inhibitors sensitivity and resistance.
Jihan K Osborne; Mitsuo Sato; David S Shames; Misty D Shields; Ignacio I Wistuba; Luc Girard; Joshua X Gonzales; Ashwinikumar Kulkarni; Jill Everland Larsen; John D Minna; Melanie H Cobb
NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM.
Alda L Tam; Ximing Tang; Anne Tsao; Ignacio I Wistuba; Christine M Alden; George R Blumenschein; Joe Ensor; Jeremy J Erasmus; Marshall E Hicks; Waun K Hong; Edward S Kim; J Jack Lee; Scott M Lippman; Sanjay Gupta
Feasibility of image-guided transthoracic core-needle biopsy in the BATTLE lung trial.

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2013: Erminia Massarelli; Heidi S Erickson; Faye M Johnson; Ignacio I Wistuba; Vassiliki A Papadimitrakopoulou
Uncommon Epidermal Growth Factor Receptor mutations in non-small cell lung cancer and their mechanisms of EGFR tyrosine kinase inhibitors sensitivity and resistance.
Lung cancer (Amsterdam, Netherlands) 2013;80(3):235-41.
2013: Jihan K Osborne; Mitsuo Sato; David S Shames; Misty D Shields; Ignacio I Wistuba; Luc Girard; Joshua X Gonzales; Ashwinikumar Kulkarni; Jill Everland Larsen; John D Minna; Melanie H Cobb
NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(16):6524-9.
2013: Alda L Tam; Ximing Tang; Anne Tsao; Ignacio I Wistuba; Christine M Alden; George R Blumenschein; Joe Ensor; Jeremy J Erasmus; Marshall E Hicks; Waun K Hong; Edward S Kim; J Jack Lee; Scott M Lippman; Sanjay Gupta
Feasibility of image-guided transthoracic core-needle biopsy in the BATTLE lung trial.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2013;8(4):436-42.
2013: Hao Tang; Michael A White; Ignacio I Wistuba; Guanghua Xiao; Jeffrey Allen; Carmen Behrens; Chi-Wan Chow; Alejandro Corvalan; Jianhua Mao; John D Minna; Joan Schiller; Milind Suraokar; Yang Xie
A 12-gene set predicts survival benefits from adjuvant chemotherapy in non-small cell lung cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(6):1577-86.
2013: Neda Kalhor; Ignacio I Wistuba
Perfecting the fine-needle aspirate cell block.
Cancer cytopathology 2013;121(3):109-10.
2013: Chengcheng Guo; Faye M Johnson; Tongyu Lin; Maria I Nunez; Ludmila Prudkin; Maria G Raso; Jack A Roth; Ruping Shao; Luisa M Solis; Stephen G Swisher; Ignacio I Wistuba; Carmen Behrens; Arlene M Correa; Bingliang Fang; Abujiang Pataer
Prognostic significance of combinations of RNA-dependent protein kinase and EphA2 biomarkers for NSCLC.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2013;8(3):301-8.
2013: William N William; Ignacio I Wistuba; Arlene M Correa; Jeremy J Erasmus; Kathryn A Gold; John Heymach; Neda Kalhor; Edward S Kim; J Jack Lee; Reginald F Munden; Vassiliki A Papadimitrakopoulou; Abujiang Pataer; David C Rice; Stephen G Swisher
Computed tomography RECIST assessment of histopathologic response and prediction of survival in patients with resectable non-small-cell lung cancer after neoadjuvant chemotherapy.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2013;8(2):222-8.
2013: Muling Mao; John M Mariadason; Gordon B Mills; Garth Powis; Xi M Tang; Feng Tian; Chun C Tsao; Ignacio I Wistuba; Gideon Bollag; William G Bornman; Michael A Davies; Farshid Dayyani; Jayesh Desai; Gary E Gallick; YN Vashisht Gopal; Zhi-Qin Jiang; Robert Lemos; Scott Kopetz
Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(3):657-67.
2013: Wusheng Yan; Lixia Diao; Michael R Emmert-Buck; Alisa M Goldstein; Nan Hu; Scott M Lippman; Audrey Player; Jaime Rodriguez-Canales; Joanna Shih; Michael A Tangrea; Philip R Taylor; Jing Wang; Ignacio I Wistuba; Heidi S Erickson
Three-dimensional mRNA measurements reveal minimal regional heterogeneity in esophageal squamous cell carcinoma.
The American journal of pathology 2013;182(2):529-39.
2013: Pierre Saintigny; Luisa M Solis Soto; Ignacio I Wistuba; Li Zhang; Young-Ho Ahn; Carmen Behrens; Yulong Chen; Baruch Erez; Sangeeta Goswami; Roy S Herbst; John V Heymach; Waun Ki Hong; Edward S Kim; Jonathan M Kurie; J Jack Lee; Steven Lin; Scott M Lippman; Diane Liu; Erminia Massarelli; Michael S O'Reilly; Yuan Ping; Ja Seok Koo
CXCR2 expression in tumor cells is a poor prognostic factor and promotes invasion and metastasis in lung adenocarcinoma.
Cancer research 2013;73(2):571-82.
2013: Humam Kadara; Edward S Kim; Wenhua Lang; J Jack Lee; Diane A Liu; Li Mao; Pierre Saintigny; Li Shen; Jing Wang; Carmen Behrens; Chi-Wan Chow; Zuoming Chu; Kevin R Coombes; You-Hong Fan; Junya Fujimoto; Melinda Garcia; Kathryn A Gold; Waun Ki Hong; Mohamed Kabbout; Ignacio I Wistuba
Characterizing the molecular spatial and temporal field of injury in early-stage smoker non-small cell lung cancer patients after definitive surgery by expression profiling.
Cancer prevention research (Philadelphia, Pa.) 2013;6(1):8-17.
2013: Kathryn A Gold; Edward S Kim; Ignacio I Wistuba; Waun K Hong
Personalizing lung cancer prevention through a reverse migration strategy.
Topics in current chemistry 2013;329():221-40.
2012: Junya Fujimoto; Melinda M Garcia; Mohamed Kabbout; Humam Kadara; Neda Kalhor; Edward S Kim; J Jack Lee; Diane D Liu; Reuben Lotan; Cesar Moran; Amir Sharafkhaneh; Luisa M Solis; Carmen Behrens; Ignacio I Wistuba
G-protein coupled receptor family C, group 5, member A (GPRC5A) expression is decreased in the adjacent field and normal bronchial epithelia of patients with chronic obstructive pulmonary disease and non-small-cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012;7(12):1747-54.
2012: Annikka Weissferdt; Ignacio I Wistuba; Cesar A Moran
Molecular aspects of thymic carcinoma.
Lung cancer (Amsterdam, Netherlands) 2012;78(2):127-32.
2012: Eric S Kim; J Jack Lee; David J Stewart; Stephen G Swisher; Ignacio I Wistuba; Chi-Wan Chow; Junya Fujimoto; Guangan He; Neda Kalhor; Zahid H Siddik
Tissue platinum concentration and tumor response in non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(27):3345-52.
2012: Lauren Averett Byers; Kevin R Coombes; Lixia Diao; Boris Duchemann; You Hong Fan; Junya Fujimoto; Luc Girard; Uma Giri; Bonnie S Glisson; Vikas Bhardwaj; Neda Kalhor; Scott M Lippman; Wenbin Liu; Fatemeh Masrorpour; Gordon B Mills; John D Minna; Monique B Nilsson; Michael Peyton; Pierre Saintigny; Li Shen; Praveen Tumula; Jing Wang; Stephanie Weber; John N Weinstein; James Welsh; Ignacio I Wistuba; John Yordy; John V Heymach
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Cancer discovery 2012;2(9):798-811.
2012: Pierre Saintigny; Banibrata Sen; Ignacio I Wistuba; Li Zhang; Luc Girard; John V Heymach; Scott M Lippman; John D Minna; Shaohua Peng; Faye M Johnson
Global evaluation of Eph receptors and ephrins in lung adenocarcinomas identifies EphA4 as an inhibitor of cell migration and invasion.
Molecular cancer therapeutics 2012;11(9):2021-32.
2012: Annikka Weissferdt; Ignacio I Wistuba; Denise Woods; Junya Fujimoto; Heather Lin; Ximing Tang; Cesar A Moran
HER family receptor and ligand status in thymic carcinoma.
Lung cancer (Amsterdam, Netherlands) 2012;77(3):515-21.
2012: Koji Tsuta; Ignacio I Wistuba; Cesar A Moran
Differential expression of somatostatin receptors 1-5 in neuroendocrine carcinoma of the lung.
Pathology, research and practice 2012;208(8):470-4.
2012: Woo-Young Kim; Lei Feng; Bonnie Glisson; Bryan Hennessy; Waun Ki Hong; Edward S Kim; J Jack Lee; Ju Seog Lee; Scott M Lippman; Ludmila Prudkin; Ignacio I Wistuba; Ho-Young Lee
Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors.
Cancer 2012;118(16):3993-4003.
2012: Yangsik Jeong; Woochang Lee; Carmen Behrens; Angie L Bookout; Adi F Gadzar; Luc Girard; John D Minna; Gabriela Raso; Ignacio I Wistuba; Yang Xie; David J Mangelsdorf
Research resource: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer.
Molecular endocrinology (Baltimore, Md.) 2012;26(8):1443-54.
2012: Iker Antón; Javier De Las Rivas; José Hermida; Jackeline Agorreta; Diego Luis-Ravelo; Susana Martínez-Canarias; Eva Molina; Luis M Montuenga; Cristina Ormazabal; María J Pajares; Naiara Perurena; Victor Segura; Karmele Valencia; Ignacio I Wistuba; Carolina Zandueta; Fernando Lecanda
Receptor of activated protein C promotes metastasis and correlates with clinical outcome in lung adenocarcinoma.
American journal of respiratory and critical care medicine 2012;186(1):96-105.
2012: Kathryn A Gold; Ignacio I Wistuba; Edward S Kim
New strategies in squamous cell carcinoma of the lung: identification of tumor drivers to personalize therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(11):3002-7.
2012: Luisa M Solis; Ximing Tang; Ignacio I Wistuba; Ping Yuan; Carmen Behrens; Hector Galindo; Humam Kadara; Neda Kalhor; J Jack Lee; Heather Y Lin; M Gabriela Raso; Cesar A Moran
Histologic patterns and molecular characteristics of lung adenocarcinoma associated with clinical outcome.
Cancer 2012;118(11):2889-99.
2012: Maria Ines Nunez; David J Stewart; Milind Suraokar; Carmen Behrens; Wilbur Franklin; Wayne Hofstetter; Humam Kadara; Neda Kalhor; J Jack Lee; Heather Lin; Denise M Woods; Ignacio I Wistuba
High expression of folate receptor alpha in lung cancer correlates with adenocarcinoma histology and EGFR [corrected] mutation.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012;7(5):833-40.
2012: Humam Kadara; Ignacio I Wistuba
Field cancerization in non-small cell lung cancer: implications in disease pathogenesis.
Proceedings of the American Thoracic Society 2012;9(2):38-42.
2012: Weiwen Long; Chen Ding; Charles E Foulds; Jian Liu; David M Lonard; Jun Qin; Jun Qin; Luisa M Solis; Ming-Jer Tsai; Sophia Y Tsai; Ignacio I Wistuba; Bert W O'Malley
ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion.
The Journal of clinical investigation 2012;122(5):1869-80.
2012: Abujiang Pataer; Maria Gabriela Raso; Jack A Roth; David J Stewart; Stephen G Swisher; Ara A Vaporciyan; Ignacio I Wistuba; Carmen Behrens; Arlene M Correa; Jeremy J Erasmus; Neda Kalhor; Edward S Kim; J Jack Lee
Histopathologic response criteria predict survival of patients with resected lung cancer after neoadjuvant chemotherapy.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012;7(5):825-32.
2012: Deeksha Vishwamitra; Desiree Wilson; Ignacio I Wistuba; Choladda V Curry; Yong Li; Roxsan Manshouri; Andrea M Sheehan; Bin Shi; Ping Shi; Xi Ming Tang; Hesham M Amin
MicroRNA 96 is a post-transcriptional suppressor of anaplastic lymphoma kinase expression.
The American journal of pathology 2012;180(5):1772-80.
2012: Jin-Soo Kim; Carmen Behrens; Waun Ki Hong; Edward S Kim; J Jack Lee; Scott M Lippman; Diane Liu; Luisa Solis; Ignacio I Wistuba; Ho-Young Lee
Prognostic impact of insulin receptor expression on survival of patients with nonsmall cell lung cancer.
Cancer 2012;118(9):2454-65.
2012: María J Pajares; Ruben Pio; Jean-Francois Timsit; Wenceslao Torre; Aurélien Vesin; Ignacio I Wistuba; Isabel Zudaire; Jackeline Agorreta; Carmen Behrens; Christian Brambilla; Elisabeth Brambilla; Teresa Ezponda; John Field; Marta Larrayoz; María D Lozano; Luis M Montuenga
Expression of tumor-derived vascular endothelial growth factor and its receptors is associated with outcome in early squamous cell carcinoma of the lung.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(10):1129-36.
2012: Osamu Takahashi; Ignacio I Wistuba; Anderson Ryan; Paul D Smith; B Nebiyou Bekele; Anna Biernacka; Baruch Erez; Roy S Herbst; Keiko Hosho; Jörg J Jacoby; Juliane M Jürgensmeier; Ritsuko Komaki; Maria V Korshunova; Michael S O'Reilly
Combined MEK and VEGFR inhibition in orthotopic human lung cancer models results in enhanced inhibition of tumor angiogenesis, growth, and metastasis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(6):1641-54.
2012: Carol M Lewis; Robert A Lustig; David I Rosenthal; Ximing Tang; Fiona Wan; Mark S Chambers; Adel K El-Naggar; Lei Feng; Bonnie S Glisson; Ignacio I Wistuba; Randal S Weber
A phase II study of gefitinib for aggressive cutaneous squamous cell carcinoma of the head and neck.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(5):1435-46.
2012: Nathan T Ihle; Edward S Kim; Jill E Larsen; J Jack Lee; Scott M Lippman; Suyu Liu; John D Minna; Vassiliki A Papadimitrakopoulou; Mena F Abdelmelek; George R Blumenschein; Lauren A Byers; Lu Chen; Kevin R Coombes; Lixia Diao; Roy S Herbst; John V Heymach; Waun K Hong; Pierre Saintigny; Ximing Tang; Anne Tsao; Jing Wang; Ignacio I Wistuba; Shuxing Zhang; Garth Powis
Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome.
Journal of the National Cancer Institute 2012;104(3):228-39.
2012: Liqin Du; Adi F Gazdar; Rachel Greer; John D Minna; Jeoffrey J Schageman; Maria C Subauste; Milind Suraokar; Ignacio I Wistuba; Chin-Rang Yang; Zhenze Zhao; Michael Baker; Robert Borkowski; Christopher DeSevo; Alexander Pertsemlidis
miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers.
PloS one 2012;7(6):e39167.
2012: William W Lockwood; Calum E MacAulay; John D Minna; Nevin Murray; Maria I Nunez; Larissa A Pikor; Luisa M Solis; Kelsie L Thu; Ming-Sound Tsao; Ian M Wilson; Ignacio I Wistuba; John Yee; Carmen Behrens; Raj Chari; Bradley P Coe; John English; Adi F Gazdar; Stephen Lam; Wan L Lam
Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.
PloS one 2012;7(5):e37775.
2012: Charles Lu; John D McMannis; Maria I Nunez; Rajagopal Ramesh; James M Reuben; Veerabhadran Baladandayuthapani; Jeremy J Erasmus; Elizabeth A Grimm; Marshall E Hicks; Gitanjali Jayachandran; Lin Ji; J Jack Lee; David J Stewart; Nancy S Templeton; Ignacio I Wistuba; Jack A Roth
Phase I clinical trial of systemically administered TUSC2(FUS1)-nanoparticles mediating functional gene transfer in humans.
PloS one 2012;7(4):e34833.
2012: Yong He; John V Heymach; Wayne L Hofstetter; Wenxian Hu; Yiling Lu; Apar Pataer; Jack A Roth; Stephen G Swisher; Jing Wang; Li Wang; Ignacio I Wistuba; Yanbin Zhou; Zhen Zhou; Lauren Averett Byers; Arlene M Correa; Lixia Diao; Chengcheng Guo; Wei Guo; Bingliang Fang
Aberrant expression of proteins involved in signal transduction and DNA repair pathways in lung cancer and their association with clinical parameters.
PloS one 2012;7(2):e31087.
2011: Anne S Tsao; Ignacio I Wistuba; Hai T Tran; George R Blumenschein; Chusilp Charnsangavej; Frank V Fossella; Junya Fujimoto; Waun K Hong; Merrill S Kies; J Jack Lee; Suyu Liu; Edith M Marom; Vassiliki A Papadimitrakopoulou; David J Stewart
Phase II trials of imatinib mesylate and docetaxel in patients with metastatic non-small cell lung cancer and head and neck squamous cell carcinoma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011;6(12):2104-11.
2011: Young-Ho Ahn; Cristina A Alvarez; Chad J Creighton; Don L Gibbons; Elizabeth J Goldsmith; Wei Lin; Jonathon Roybal; Nishan Thilaganathan; Cathy Tournier; Ignacio I Wistuba; Fei Yang; Yanan Yang; Jonathan M Kurie
Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor γ2 expression.
Molecular and cellular biology 2011;31(21):4270-85.
2011: Anne S Tsao; Wei Wei; Waun Ki Hong; Elisabetta Kuhn; J Jack Lee; Luisa M Solis; Loreto Spencer; Milind Suraokar; Ignacio I Wistuba
Immunohistochemical overexpression of platelet-derived growth factor receptor-beta (PDGFR-β) is associated with PDGFRB gene copy number gain in sarcomatoid non-small-cell lung cancer.
Clinical lung cancer 2011;12(6):369-74.
2011: Koji Tsuta; Ignacio I Wistuba; Neda Kalhor; Cesar A Moran
Clinicopathological and immunohistochemical analysis of spindle-cell carcinoid tumour of the lung.
Histopathology 2011;59(3):526-36.
2011: Min P Kim; Adriana Lopez; Jack A Roth; Luisa Solis; Margaret R Spitz; Marnie Wismach; Ignacio I Wistuba; Carmen Behrens; B Nebiyou Bekele; Jie Qing Chen; Ying Chen; Lin Ji; Abha Khanna; Ruth L Katz
Activating enhancer-binding protein-2β nucleolar localization predicts poor survival after stage I non-small cell lung cancer resection.
The Annals of thoracic surgery 2011;92(3):1044-50.
2011: Yang Xie; Guanghua Xiao; Carmen Behrens; Kevin R Coombes; Kathy Danenberg; Heidi S Erickson; Luc Girard; John V Heymach; John D Minna; Cesar Moran; Gabriela Raso; Jack Roth; Luisa M Solis; Ignacio I Wistuba
Robust gene expression signature from formalin-fixed paraffin-embedded samples predicts prognosis of non-small-cell lung cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(17):5705-14.
2011: Fei Yang; Ximing Tang; Erick Riquelme; Carmen Behrens; Monique B Nilsson; Uma Giri; Marileila Varella-Garcia; Lauren A Byers; Heather Y Lin; Jing Wang; Maria G Raso; Luc Girard; Kevin Coombes; J Jack Lee; Roy S Herbst; John D Minna; John V Heymach; Ignacio I Wistuba
Increased VEGFR-2 gene copy is associated with chemoresistance and shorter survival in patients with non-small-cell lung carcinoma who receive adjuvant chemotherapy.
Cancer research 2011;71(16):5512-21.
2011: Kathryn A Gold; Edward S Kim; J Jack Lee; Ignacio I Wistuba; Carol J Farhangfar; Waun Ki Hong
The BATTLE to personalize lung cancer prevention through reverse migration.
Cancer prevention research (Philadelphia, Pa.) 2011;4(7):962-72.
2011: Mariano Ponz-Sarvisé; Miriam Redrado; Ignacio I Wistuba; Jackeline Agorreta; Carmen Behrens; Alfonso Calvo; Jesús García-Foncillas; Carlos E García-Franco; María D Lozano; Luis M Montuenga; Paul A Nguewa; María J Pajares; Ruben Pio; Ignacio Gil-Bazo
Inhibitor of differentiation-1 as a novel prognostic factor in NSCLC patients with adenocarcinoma histology and its potential contribution to therapy resistance.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(12):4155-66.
2011: Marc Damelin; Veronica Diesl; John F DiJoseph; Maureen Dougher; Deborah Evans; Maximillian T Follettie; Kenneth G Geles; Jonathon Golas; Janet Gruzas; Philip R Hamann; Shuguang Huang; Maha Karnoub; Kiran Khandke; Arthur Kunz; Kimberly Marquette; Carol Rios; Latha Sridharan; Lioudmila Tchistiakova; Ignacio I Wistuba; Ping Yuan; Robert T Abraham; Douglas Armellino; Michelle Baxter; Carmen Behrens; Erwin R Boghaert; Sung E Choe; Bin-Bing S Zhou
Delineation of a cellular hierarchy in lung cancer reveals an oncofetal antigen expressed on tumor-initiating cells.
Cancer research 2011;71(12):4236-46.
2011: Edward S Kim; J Jack Lee; Scott M Lippman; Suyu Liu; Li Mao; Vassiliki Papadimitrakopoulou; David J Stewart; Ximing Tang; Hai T Tran; Anne Tsao; Ignacio I Wistuba; Christine M Alden; George R Blumenschein; Suzanne E Davis; Jeremy Erasmus; Frank Fossella; Sanjay Gupta; Roy S Herbst; John V Heymach; Marshall E Hicks; Bruce E Johnson; Fadlo R Khuri; Merrill S Kies; Waun K Hong
The BATTLE trial: personalizing therapy for lung cancer.
Cancer discovery 2011;1(1):44-53.
2011: Edward S Kim; J Jack Lee; Ignacio I Wistuba
Cotargeting cyclin D1 starts a new chapter in lung cancer prevention and therapy.
Cancer prevention research (Philadelphia, Pa.) 2011;4(6):779-82.
2011: Woo-Young Kim; Mi-Jung Kim; Hojin Moon; Ping Yuan; Jin-Soo Kim; Jong-Kyu Woo; Guangcheng Zhang; Young-Ah Suh; Lei Feng; Carmen Behrens; Carolyn S Van Pelt; Hyunseok Kang; J Jack Lee; Waun Ki Hong; Ignacio I Wistuba; Ho-Young Lee
Differential impacts of insulin-like growth factor-binding protein-3 (IGFBP-3) in epithelial IGF-induced lung cancer development.
Endocrinology 2011;152(6):2164-73.
2011: Ximing Tang; Humam Kadara; Carmen Behrens; Diane D Liu; Yun Xiao; David Rice; Adi F Gazdar; Junya Fujimoto; Cesar Moran; Marileila Varella-Garcia; J Jack Lee; Waun Ki Hong; Ignacio I Wistuba
Abnormalities of the TITF-1 lineage-specific oncogene in NSCLC: implications in lung cancer pathogenesis and prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2434-43.
2011: Koji Tsuta; Neda Kalhor; Maria Gabriela Raso; Ignacio I Wistuba; Cesar A Moran
Oncocytic neuroendocrine tumors of the lung: histopathologic spectrum and immunohistochemical analysis of 15 cases.
Human pathology 2011;42(4):578-85.
2011: Humam Kadara; Carmen Behrens; Ping Yuan; Luisa Solis; Diane Liu; Xuemin Gu; John D Minna; J Jack Lee; Edward Kim; Waun Ki Hong; Ignacio I Wistuba; Reuben Lotan
A five-gene and corresponding protein signature for stage-I lung adenocarcinoma prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(6):1490-501.
2011: Ignacio I Wistuba; Juri G Gelovani; Jörg J Jacoby; Suzanne E Davis; Roy S Herbst
Methodological and practical challenges for personalized cancer therapies.
Nature reviews. Clinical oncology 2011;8(3):135-41.
2011: Brigitte N Gomperts; Avrum Spira; Pierre P Massion; Tonya C Walser; Ignacio I Wistuba; John D Minna; Steven M Dubinett
Evolving concepts in lung carcinogenesis.
Seminars in respiratory and critical care medicine 2011;32(1):32-43.
2011: Kristy L Richards; Baili Zhang; Menghong Sun; Wenli Dong; Jennifer Churchill; Linda L Bachinski; Charmaine D Wilson; Keith A Baggerly; Guosheng Yin; David Hayes; Ignacio I Wistuba; Ralf Krahe
Methylation of the candidate biomarker TCF21 is very frequent across a spectrum of early-stage nonsmall cell lung cancers.
Cancer 2011;117(3):606-17.
2011: David J Stewart; Carmen Behrens; Jack Roth; Ignacio I Wistuba
Exponential decay nonlinear regression analysis of patient survival curves: preliminary assessment in non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2011;71(2):217-23.
2011: Yong He; Wayne L Hofstetter; Carmen Behrens; Arlene M Correa; Bingliang Fang; Maria Gabriela Raso; Jack A Roth; Stephen G Swisher; Ignacio I Wistuba; Liping Yu; Yihong Zhou; Apar Pataer
The role of PKR/eIF2α signaling pathway in prognosis of non-small cell lung cancer.
PloS one 2011;6(11):e24855.
2011: Yun-Ju Chen; Chao-Kai Chou; Tse-Chuan Chou; Sheng-Chieh Hsu; Wei-Chien Huang; Kwang-Yu Chang; Wen-Chang Chang; J Jack Lee; Heather Y Lin; Wu-Chou Su; Chang-Hai Tsai; Ya-Ling Wei; Ignacio I Wistuba; Chia-Jui Yen; Ping Yuan; Mien-Chie Hung
Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells.
PloS one 2011;6(6):e21428.
2011: Koji Tsuta; Maria G Raso; Neda Kalhor; Diane C Liu; Ignacio I Wistuba; Cesar A Moran
Sox10-positive sustentacular cells in neuroendocrine carcinoma of the lung.
Histopathology 2011;58(2):276-85.
2011: Koji Tsuta; Maria G Raso; Neda Kalhor; Diane D Liu; Ignacio I Wistuba; Cesar A Moran
Histologic features of low- and intermediate-grade neuroendocrine carcinoma (typical and atypical carcinoid tumors) of the lung.
Lung cancer (Amsterdam, Netherlands) 2011;71(1):34-41.
2010: Meera Nanjundan; Lauren Averett Byers; Mark S Carey; Doris R Siwak; Maria Gabriela Raso; Lixia Diao; Jing Wang; Kevin R Coombes; Jack A Roth; Gordon B Mills; Ignacio I Wistuba; John D Minna; John V Heymach
Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2010;5(12):1894-904.
2010: James P Sullivan; Monica Spinola; Michael Dodge; Maria G Raso; Carmen Behrens; Boning Gao; Katja Schuster; Chunli Shao; Jill E Larsen; Laura A Sullivan; Sofia Honorio; Yang Xie; Pier P Scaglioni; J Michael DiMaio; Adi F Gazdar; Jerry W Shay; Ignacio I Wistuba; John D Minna
Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling.
Cancer research 2010;70(23):9937-48.
2010: Abujiang Pataer; Maria Gabriela Raso; Arlene M Correa; Carmen Behrens; Koji Tsuta; Luisa Solis; Bingliang Fang; Jack A Roth; Ignacio I Wistuba; Stephen G Swisher
Prognostic significance of RNA-dependent protein kinase on non-small cell lung cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(22):5522-8.
2010: Pierre Saintigny; Ignacio I Wistuba; Edward S Kim
Bronchioloalveolar carcinoma: a translational perspective.
Oncology (Williston Park, N.Y.) 2010;24(10):907-8, 914.
2010: Aik T Ooi; Vei Mah; Derek W Nickerson; Jennifer L Gilbert; Vi Luan Ha; Ahmed E Hegab; Steve Horvath; Mohammad Alavi; Erin L Maresh; David Chia; Adam C Gower; Marc E Lenburg; Avrum Spira; Luisa M Solis; Ignacio I Wistuba; Tonya C Walser; William D Wallace; Steven M Dubinett; Lee Goodglick; Brigitte N Gomperts
Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer.
Cancer research 2010;70(16):6639-48.
2010: Luisa M Solis; Carmen Behrens; Wenli Dong; Milind Suraokar; Natalie C Ozburn; Cesar A Moran; Alejandro Corvalan; Shyam Biswal; Stephen G Swisher; B Nebiyou Bekele; John D Minna; David J Stewart; Ignacio I Wistuba
Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(14):3743-53.
2010: Lauren Averett Byers; F Christopher Holsinger; Merrill S Kies; William N William; Adel K El-Naggar; J Jack Lee; Jianhua Hu; Adriana Lopez; Hai T Tran; Shaoyu Yan; Zhiqiang Du; K Kian Ang; Bonnie S Glisson; Maria Gabriela Raso; Ignacio I Wistuba; Jeffrey N Myers; Waun Ki Hong; Vassiliki A Papadimitrakopoulou; Scott M Lippman; John V Heymach
Serum signature of hypoxia-regulated factors is associated with progression after induction therapy in head and neck squamous cell cancer.
Molecular cancer therapeutics 2010;9(6):1755-63.
2010: J Jack Lee; Lei Feng; Daniel S Reshef; Anita L Sabichi; Brendell Williams; Waree Rinsurongkawong; Ignacio I Wistuba; Reuben Lotan; Scott M Lippman
Mortality in the randomized, controlled lung intergroup trial of isotretinoin.
Cancer prevention research (Philadelphia, Pa.) 2010;3(6):738-44.
2010: Lei Xu; M B Nilsson; P Saintigny; T Cascone; Matthew H Herynk; Z Du; P G Nikolinakos; Ying Yang; Ludmila Prudkin; Diane Liu; J Jack Lee; Faye M Johnson; Kwong-Kwok Wong; L Girard; Adi F Gazdar; John D Minna; Jonathan M Kurie; Ignacio I Wistuba; John V Heymach
Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1alpha in non-small cell lung cancer cells.
Oncogene 2010;29(18):2616-27.
2010: Kristin A Spivey; Jacqueline Banyard; Luisa M Solis; Ignacio I Wistuba; Justine A Barletta; Leena Gandhi; Henry A Feldman; Scott J Rodig; Lucian R Chirieac; Bruce R Zetter
Collagen XXIII: a potential biomarker for the detection of primary and recurrent non-small cell lung cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010;19(5):1362-72.
2010: Edward S Kim; Waun K Hong; J Jack Lee; Li Mao; Rodolfo C Morice; Diane D Liu; Carlos A Jimenez; Georgie A Eapen; Reuben Lotan; Ximing Tang; Robert A Newman; Ignacio I Wistuba; Jonathan M Kurie
Biological activity of celecoxib in the bronchial epithelium of current and former smokers.
Cancer prevention research (Philadelphia, Pa.) 2010;3(2):148-59.
2010: Doina Ivan; Victor G Prieto; Bita Esmaeli; Ignacio I Wistuba; Ximing Tang; Alexander Lazar
Epidermal growth factor receptor (EGFR) expression in periocular and extraocular sebaceous carcinoma.
Journal of cutaneous pathology 2010;37(2):231-6.
2010: Yangsik Jeong; Yang Xie; Guanghua Xiao; Carmen Behrens; Luc Girard; Ignacio I Wistuba; John D Minna; David J Mangelsdorf
Nuclear receptor expression defines a set of prognostic biomarkers for lung cancer.
PLoS medicine 2010;7(12):e1000378.
2010: Ping Yuan; Humam Kadara; Carmen Behrens; Ximing Tang; Denise Woods; Luisa M Solis; Jiaoti Huang; Monica Spinola; Wenli Dong; Guosheng Yin; Junya Fujimoto; Edward Kim; Yang Xie; Luc Girard; Cesar Moran; Waun Ki Hong; John D Minna; Ignacio I Wistuba
Sex determining region Y-Box 2 (SOX2) is a potential cell-lineage gene highly expressed in the pathogenesis of squamous cell carcinomas of the lung.
PloS one 2010;5(2):e9112.
2010: Carmen Behrens; Lei Feng; Humam Kadara; Hyun-Jung Kim; J Jack Lee; Reza Mehran; Waun Ki Hong; Reuben Lotan; Ignacio I Wistuba
Expression of interleukin-1 receptor-associated kinase-1 in non-small cell lung carcinoma and preneoplastic lesions.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(1):34-44.
2010: Luisa M Solis; M Gabriela Raso; Neda Kalhor; Carmen Behrens; Ignacio I Wistuba; Cesar A Moran
Primary oncocytic adenocarcinomas of the lung: a clinicopathologic, immunohistochemical, and molecular biologic analysis of 16 cases.
American journal of clinical pathology 2010;133(1):133-40.
2009: Jennifer M Brannan; Banibrata Sen; Babita Saigal; Ludmila Prudkin; Carmen Behrens; Luisa Solis; Wenli Dong; B Nebiyou Bekele; Ignacio I Wistuba; Faye M Johnson
EphA2 in the early pathogenesis and progression of non-small cell lung cancer.
Cancer prevention research (Philadelphia, Pa.) 2009;2(12):1039-49.
2009: Anne S Tsao; Diane Liu; Jack Martin; Xi-ming Tang; J Jack Lee; Adel K El-Naggar; Ignacio I Wistuba; Kirk S Culotta; Li Mao; Ann M Gillenwater; Yuko M Sagesaka; Waun K Hong; Vassiliki A Papadimitrakopoulou
Phase II randomized, placebo-controlled trial of green tea extract in patients with high-risk oral premalignant lesions.
Cancer prevention research (Philadelphia, Pa.) 2009;2(11):931-41.
2009: Alex H Ramos; Amit Dutt; Craig Mermel; Sven Perner; Jeonghee Cho; Christopher J Lafargue; Laura A Johnson; Ann-Cathrin Stiedl; Kumiko E Tanaka; Adam J Bass; Jordi Barretina; Barbara A Weir; Rameen Beroukhim; Roman K Thomas; John D Minna; Lucian R Chirieac; Neal Lindeman; Thomas J Giordano; David G Beer; Patrick Wagner; Ignacio I Wistuba; Mark A Rubin; Matthew Meyerson
Amplification of chromosomal segment 4q12 in non-small cell lung cancer.
Cancer biology & therapy 2009;8(21):2042-50.
2009: Woo-Young Kim; Quanri Jin; Seung-Hyun Oh; Edward S Kim; Youn Joo Yang; Dong Hoon Lee; Lei Feng; Carmen Behrens; Ludmila Prudkin; York E Miller; J Jack Lee; Scott M Lippman; Waun Ki Hong; Ignacio I Wistuba; Ho-Young Lee
Elevated epithelial insulin-like growth factor expression is a risk factor for lung cancer development.
Cancer research 2009;69(18):7439-48.
2009: William Pao; Mark G Kris; A John Iafrate; Marc Ladanyi; Pasi A Janne; Ignacio I Wistuba; Ryn Miake-Lye; Roy S Herbst; David P Carbone; Bruce E Johnson; Thomas J Lynch
Integration of molecular profiling into the lung cancer clinic.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(17):5317-22.
2009: Maria G Raso; Carmen Behrens; Matthew H Herynk; Suyu Liu; Ludmila Prudkin; Natalie Ozburn; Denise M Woods; Ximing Tang; Reza J Mehran; Cesar Moran; J Jack Lee; Ignacio I Wistuba
Immunohistochemical expression of estrogen and progesterone receptors identifies a subset of NSCLCs and correlates with EGFR mutation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(17):5359-68.
2009: Liqin Du; Jeoffrey Schageman; Maria C Subauste; Barbara Saber; Scott M Hammond; Ludmila Prudkin; Ignacio I Wistuba; Lin Ji; Jack A Roth; John D Minna; Alexander Pertsemlidis
miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1.
Molecular cancer research : MCR 2009;7(8):1234-43.
2009: Humam Kadara; ludovic lacroix; Carmen Behrens; Luisa Solis; Xuemin Gu; J Jack Lee; Eiji Tahara; Dafna Lotan; Waun Ki Hong; Ignacio I Wistuba; Reuben Lotan
Identification of gene signatures and molecular markers for human lung cancer prognosis using an in vitro lung carcinogenesis system.
Cancer prevention research (Philadelphia, Pa.) 2009;2(8):702-11.
2009: Menghong Sun; Carmen Behrens; Lei Feng; Natalie Ozburn; Ximing Tang; Guosheng Yin; Ritsuko Komaki; Marileila Varella-Garcia; Waun Ki Hong; Kenneth Aldape; Ignacio I Wistuba
HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(15):4829-37.
2009: Jennifer M Brannan; Wenli Dong; Ludmila Prudkin; Carmen Behrens; Reuben Lotan; B Nebiyou Bekele; Ignacio I Wistuba; Faye M Johnson
Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(13):4423-30.
2009: David J Stewart; Jean-Pierre J Issa; Razelle Kurzrock; Maria I Nunez; Jaroslav Jelinek; David Hong; Yasuhiro Oki; Zhong Guo; Sanjay Gupta; Ignacio I Wistuba
Decitabine effect on tumor global DNA methylation and other parameters in a phase I trial in refractory solid tumors and lymphomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(11):3881-8.
2009: Pablo Uribe; Ignacio I Wistuba; Sergio Gonzalez
Allelotyping, microsatellite instability, and BRAF mutation analyses in common and atypical melanocytic nevi and primary cutaneous melanomas.
The American Journal of dermatopathology 2009;31(4):354-63.
2009: Ludmila Prudkin; Diane D Liu; Natalie Ozburn; Menghong Sun; Carmen Behrens; Ximing Tang; Kathlynn Brown; B Nebiyou Bekele; Cesar Moran; Ignacio I Wistuba
Epithelial-to-mesenchymal transition in the development and progression of adenocarcinoma and squamous cell carcinoma of the lung.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009;22(5):668-78.
2009: Anne S Tsao; Ignacio I Wistuba; Jack A Roth; Hedy Lee Kindler
Malignant pleural mesothelioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(12):2081-90.
2009: Seyed Javad Moghaddam; Huaiguang Li; Sung-Nam Cho; Megan K Dishop; Ignacio I Wistuba; Lin Ji; Jonathan M Kurie; Burton F Dickey; Francesco J DeMayo
Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model.
American journal of respiratory cell and molecular biology 2009;40(4):443-53.
2009: Samanthi A Perera; Danan Li; Takeshi Shimamura; Maria G Raso; Hongbin Ji; Liang Chen; Christa L Borgman; Sara Zaghlul; Kathleyn A Brandstetter; Shigeto Kubo; Masaya Takahashi; Lucian R Chirieac; Robert F Padera; Roderick T Bronson; Geoffrey I Shapiro; Heidi Greulich; Matthew Meyerson; Ulrich Guertler; Pilar Garin Chesa; Flavio Solca; Ignacio I Wistuba; Kwok-Kin Wong
HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(2):474-9.
2009: Junichi Soh; Naoki Okumura; William W Lockwood; Hiromasa Yamamoto; Hisayuki Shigematsu; Wei Zhang; Raj Chari; David S Shames; Ximing Tang; Calum MacAulay; Marileila Varella-Garcia; Tõnu Vooder; Ignacio I Wistuba; Stephen Lam; Rolf Brekken; Shinichi Toyooka; John D Minna; Wan L Lam; Adi F Gazdar
Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells.
PloS one 2009;4(10):e7464.
2009: Don L Gibbons; Wei Lin; Chad J Creighton; Shuling Zheng; Dror Berel; Y Yang; Maria Gabriela Raso; Diane D Liu; Ignacio I Wistuba; Guillermina Lozano; Jonathan M Kurie
Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma.
PloS one 2009;4(4):e5401.
2008: J Matthew McDonald; Christopher E Pelloski; Alicia Ledoux; Menghong Sun; Gabriela Raso; Ritsuko Komaki; Ignacio I Wistuba; B Nebiyou Bekele; Kenneth Aldape
Elevated phospho-S6 expression is associated with metastasis in adenocarcinoma of the lung.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(23):7832-7.
2008: Ignacio I Wistuba; Matthew Meyerson
Chromosomal deletions and progression of premalignant lesions: less is more.
Cancer prevention research (Philadelphia, Pa.) 2008;1(6):404-8.
2008: Yerko Borghero; Christopher H Crane; Janio Szklaruk; Mauricio Oyarzo; Steven Curley; Peter W Pisters; Douglas Evans; Eddie K Abdalla; Melanie Thomas; Prajnan Das; Ignacio I Wistuba; Sunil Krishnan; Jean-Nicolas Vauthey
Extrahepatic bile duct adenocarcinoma: patients at high-risk for local recurrence treated with surgery and adjuvant chemoradiation have an equivalent overall survival to patients with standard-risk treated with surgery alone.
Annals of surgical oncology 2008;15(11):3147-56.
2008: Carmen Behrens; Heather Y Lin; J Jack Lee; Maria Gabriela Raso; Waun Ki Hong; Ignacio I Wistuba; Reuben Lotan
Immunohistochemical expression of basic fibroblast growth factor and fibroblast growth factor receptors 1 and 2 in the pathogenesis of lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(19):6014-22.
2008: Narayan Shivapurkar; Victor Stastny; Naoki Okumura; Luc Girard; Yang Xie; Clemens Prinsen; Frederik B Thunnissen; Ignacio I Wistuba; Bogdan Czerniak; Eugene P Frenkel; Jack A Roth; Triantafillos Liloglou; George Xinarianos; John Field; John D Minna; Adi F Gazdar
Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene.
Cancer research 2008;68(18):7448-56.
2008: Hiromasa Yamamoto; Hisayuki Shigematsu; Masaharu Nomura; William W Lockwood; Mitsuo Sato; Naoki Okumura; Junichi Soh; Makoto Suzuki; Ignacio I Wistuba; Kwun M Fong; Huei Lee; Shinichi Toyooka; Hiroshi Date; Wan L Lam; John D Minna; Adi F Gazdar
PIK3CA mutations and copy number gains in human lung cancers.
Cancer research 2008;68(17):6913-21.
2008: Jie Zhang; Kentaro Iwanaga; Kuicheon C Choi; Marie Wislez; Maria Gabriela Raso; Wei Wei; Ignacio I Wistuba; Jonathan M Kurie
Intratumoral epiregulin is a marker of advanced disease in non-small cell lung cancer patients and confers invasive properties on EGFR-mutant cells.
Cancer prevention research (Philadelphia, Pa.) 2008;1(3):201-7.
2008: Ximing Tang; Marileila Varella-Garcia; Ana C Xavier; Erminia Massarelli; Natalie Ozburn; Cesar Moran; Ignacio I Wistuba
Epidermal growth factor receptor abnormalities in the pathogenesis and progression of lung adenocarcinomas.
Cancer prevention research (Philadelphia, Pa.) 2008;1(3):192-200.
2008: Hye-Sook Seo; Diane D Liu; B Nebiyou Bekele; Mi-Kyoung Kim; Katherine Pisters; Scott M Lippman; Ignacio I Wistuba; Ja Seok Koo
Cyclic AMP response element-binding protein overexpression: a feature associated with negative prognosis in never smokers with non-small cell lung cancer.
Cancer research 2008;68(15):6065-73.
2008: Elisabetta Kuhn; Ignacio I Wistuba
Molecular pathology of thymic epithelial neoplasms.
Hematology/oncology clinics of North America 2008;22(3):443-55.
2008: Alfredo Velasco; Alejandro Corvalan; Ignacio I Wistuba; Erick Riquelme; Rodrigo Chuaqui; Alejandro Majerson; Fredrick S Leach
Mismatch repair expression in testicular cancer predicts recurrence and survival.
International journal of cancer. Journal international du cancer 2008;122(8):1774-7.
2008: Y Yang; Marie Wislez; Nobukazu Fujimoto; Ludmila Prudkin; Julie G Izzo; Futoshi Uno; Lin Ji; Amy E Hanna; Robert R Langley; Diane Liu; Faye M Johnson; Ignacio I Wistuba; Jonathan M Kurie
A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras.
Molecular cancer therapeutics 2008;7(4):952-60.
2008: Kentaro Iwanaga; Y Yang; Maria Gabriela Raso; Lijiang Ma; Amy E Hanna; Nishan Thilaganathan; Seyed Moghaddam; Christopher M Evans; Huaiguang Li; Wei-Wen Cai; Mitsuo Sato; John D Minna; Hong Wu; Chad J Creighton; Francesco J DeMayo; Ignacio I Wistuba; Jonathan M Kurie
Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer.
Cancer research 2008;68(4):1119-27.
2008: Helena Deus; Romesh Stanislaus; Diogo F Veiga; Carmen Behrens; Ignacio I Wistuba; John D Minna; Harold R Garner; Stephen G Swisher; Jack A Roth; Arlene M Correa; Bradley Broom; Kevin R Coombes; Allen Chang; Lynn H Vogel; Jonas Almeida
A Semantic Web management model for integrative biomedical informatics.
PloS one 2008;3(8):e2946.
2008: Y Yang; Kentaro Iwanaga; Maria Gabriela Raso; Marie Wislez; Amy E Hanna; Eric Wieder; Jeffrey J Molldrem; Ignacio I Wistuba; Garth Powis; Francesco J DeMayo; Carla F. Kim; Jonathan M Kurie
Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer.
PloS one 2008;3(5):e2220.
2008: Ludmila Prudkin; Carmen Behrens; Diane D Liu; Xian Zhou; Natalie Ozburn; B Nebiyou Bekele; John D Minna; Cesar Moran; Jack A Roth; Lin Ji; Ignacio I Wistuba
Loss and reduction of FUS1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(1):41-7.
2007: Quanri Jin; Lei Feng; Carmen Behrens; B Nebiyou Bekele; Ignacio I Wistuba; Waun Ki Hong; Ho-Young Lee
Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin.
Cancer research 2007;67(24):11630-9.
2007: Toru Kawamoto; Savitri Krishnamurthy; Emily Tarco; Smita Trivedi; Ignacio I Wistuba; Donghui Li; Ivan Roa; Juan C Roa; Melanie Thomas
HER Receptor Family: Novel Candidate for Targeted Therapy for Gallbladder and Extrahepatic Bile Duct Cancer.
Gastrointestinal cancer research : GCR 2007;1(6):221-7.
2007: Vei Mah; David Seligson; Ai Li; Diana C Márquez; Ignacio I Wistuba; Yahya Elshimali; Michael C Fishbein; David Chia; Richard J Pietras; Lee Goodglick
Aromatase expression predicts survival in women with early-stage non small cell lung cancer.
Cancer research 2007;67(21):10484-90.
2007: Shinichi Toyooka; Keitaro Matsuo; Hisayuki Shigematsu; Takayuki Kosaka; Masaki Tokumo; Yasushi Yatabe; Shuji Ichihara; Michio Inukai; Hiroshi Suehisa; Junichi Soh; Katsuyuki Kiura; Kwun M Fong; Huei Lee; Ignacio I Wistuba; Adi F Gazdar; Tetsuya Mitsudomi; Hiroshi Date
The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(19):5763-8.
2007: Seung-Wook Kim; Kyounga Cheon; Chang-Hoon Kim; Joo-Heon Yoon; David H Hawke; Ryuji Kobayashi; Ludmila Prudkin; Ignacio I Wistuba; Reuben Lotan; Waun Ki Hong; Ja Seok Koo
Proteomics-based identification of proteins secreted in apical surface fluid of squamous metaplastic human tracheobronchial epithelial cells cultured by three-dimensional organotypic air-liquid interface method.
Cancer research 2007;67(14):6565-73.
2007: Anne S Tsao; Dandan He; Babita Saigal; Suyu Liu; J Jack Lee; Srinivasa Bakkannagari; Nelson G Ordonez; Waun Ki Hong; Ignacio I Wistuba; Faye M Johnson
Inhibition of c-Src expression and activation in malignant pleural mesothelioma tissues leads to apoptosis, cell cycle arrest, and decreased migration and invasion.
Molecular cancer therapeutics 2007;6(7):1962-72.
2007: Maria Gabriela Raso; Ignacio I Wistuba
Molecular pathogenesis of early-stage non-small cell lung cancer and a proposal for tissue banking to facilitate identification of new biomarkers.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2007;2(7 Suppl 3):S128-35.
2007: Anissa N Elayadi; Kausar N Samli; Ludmila Prudkin; Ying-Horng Liu; Aihua Bian; Xian-Jin Xie; Ignacio I Wistuba; Jack A Roth; Michael J McGuire; Kathlynn Brown
A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancer.
Cancer research 2007;67(12):5889-95.
2007: Erick Riquelme; Moying Tang; Sergio Baez; Alfonso Diaz; Martha Pruyas; Ignacio I Wistuba; Alejandro Corvalan
Frequent epigenetic inactivation of chromosome 3p candidate tumor suppressor genes in gallbladder carcinoma.
Cancer letters 2007;250(1):100-6.
2007: Erminia Massarelli; Marileila Varella-Garcia; Ximing Tang; Ana C Xavier; Natalie Ozburn; Diane D Liu; B Nebiyou Bekele; Roy S Herbst; Ignacio I Wistuba
KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(10):2890-6.
2007: T S Khatlani; Marie Wislez; Menghong Sun; Harish Srinivas; K Iwanaga; Long Ma; Amy E Hanna; D Liu; L Girard; Y H Kim; Jonathan R Pollack; John D Minna; Ignacio I Wistuba; Jonathan M Kurie
c-Jun N-terminal kinase is activated in non-small-cell lung cancer and promotes neoplastic transformation in human bronchial epithelial cells.
Oncogene 2007;26(18):2658-66.
2007: Masaharu Nomura; Hisayuki Shigematsu; Lin Li; Makoto Suzuki; Takao Takahashi; Pila Estess; Mark Siegelman; Ziding Feng; Harubumi Kato; Antonio Marchetti; Jerry W Shay; Margaret R Spitz; Ignacio I Wistuba; John D Minna; Adi F Gazdar
Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers.
PLoS medicine 2007;4(4):e125.
2007: Narayan Shivapurkar; Victor Stastny; Makoto Suzuki; Ignacio I Wistuba; Lin Li; Yingye Zheng; Ziding Feng; Bernard Hol; Clemens F M Prinsen; Frederik B J M Thunnissen; Adi F Gazdar
Application of a methylation gene panel by quantitative PCR for lung cancers.
Cancer letters 2007;247(1):56-71.
2007: Kevin Haigis; Ignacio I Wistuba; Jonathan M Kurie
Lung premalignancy induced by mutant B-Raf, what is thy fate? To senesce or not to senesce, that is the question.
Genes & development 2007;21(4):361-6.
2007: Dianren Xia; Harish Srinivas; Young-Ho Ahn; Gautam Sethi; Xiaoyang Sheng; W K Alfred Yung; Qianghua Xia; Paul J Chiao; Heetae Kim; Powel H Brown; Ignacio I Wistuba; Bharat B Aggarwal; Jonathan M Kurie
Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway.
The Journal of biological chemistry 2007;282(6):3507-19.
2007: Ignacio I Wistuba
Genetics of preneoplasia: lessons from lung cancer.
Current molecular medicine 2007;7(1):3-14.
2007: Jie Zhang; Shailaja Kalyankrishna; Marie Wislez; Nishan Thilaganathan; Babita Saigal; Wei Wei; Long Ma; Ignacio I Wistuba; Faye M Johnson; Jonathan M Kurie
SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines.
The American journal of pathology 2007;170(1):366-76.
2006: Jian Gu; berman david; Charles Lu; Ignacio I Wistuba; Jack A Roth; Marsha L Frazier; Margaret R Spitz; Xifeng Wu
Aberrant promoter methylation profile and association with survival in patients with non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(24):7329-38.
2006: Jie Shen; Carmen Behrens; Ignacio I Wistuba; Lei Feng; J Jack Lee; Waun Ki Hong; Reuben Lotan
Identification and validation of differences in protein levels in normal, premalignant, and malignant lung cells and tissues using high-throughput Western Array and immunohistochemistry.
Cancer research 2006;66(23):11194-206.
2006: Ximing Tang; Diane Liu; Shishir Shishodia; Natalie Ozburn; Carmen Behrens; J Jack Lee; Waun Ki Hong; Bharat B Aggarwal; Ignacio I Wistuba
Nuclear factor-kappaB (NF-kappaB) is frequently expressed in lung cancer and preneoplastic lesions.
Cancer 2006;107(11):2637-46.
2006: William D Travis; Kavita Garg; Wilbur A Franklin; Ignacio I Wistuba; Bradley Sabloff; Masayuki Noguchi; Ryutaro Kakinuma; Maureen F Zakowski; Michelle Ginsberg; Robert F Padera; Francine Jacobson; Bruce E Johnson; Fred Hirsch; Elizabeth Brambilla; Douglas B Flieder; Kim R Geisinger; Frederik B J M Thunnissen; Keith Kerr; David Yankelevitz; Teri J Franks; Jeffrey Galvin; Douglas W Henderson; Andrew G Nicholson; Philip S Hasleton; Victor L Roggli; Ming Tsao; Federico Cappuzzo; Madeline Vazquez
Bronchioloalveolar carcinoma and lung adenocarcinoma: the clinical importance and research relevance of the 2004 World Health Organization pathologic criteria.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006;1(9 Suppl):S13-9.
2006: Ludmila Prudkin; Ignacio I Wistuba
Epidermal growth factor receptor abnormalities in lung cancer. Pathogenetic and clinical implications.
Annals of diagnostic pathology 2006;10(5):306-15.
2006: Marie Wislez; Nobukazu Fujimoto; Julie G Izzo; Amy E Hanna; Dianna D Cody; Robert R Langley; Hongli Tang; Marie D Burdick; Mitsuo Sato; John D Minna; Li Mao; Ignacio I Wistuba; Robert M Strieter; Jonathan M Kurie
High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras.
Cancer research 2006;66(8):4198-207.
2006: Anne S Tsao; Xi Ming Tang; Bradley Sabloff; Lianchun Xiao; Hisayuki Shigematsu; Jack Roth; Margaret Spitz; Waun Ki Hong; Adi F Gazdar; Ignacio I Wistuba
Clinicopathologic characteristics of the EGFR gene mutation in non-small cell lung cancer.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006;1(3):231-9.
2006: Ignacio I Wistuba; Adi F Gazdar
Lung cancer preneoplasia.
Annual review of pathology 2006;1():331-48.
2005: Nobukazu Fujimoto; Marie Wislez; Jie Zhang; Kentaro Iwanaga; Jennifer Dackor; Amy E Hanna; Shailaja Kalyankrishna; Dianna D Cody; Roger E Price; Mitsuo Sato; Jerry W Shay; John D Minna; Michael Peyton; Ximing Tang; Erminia Massarelli; Roy Herbst; David Threadgill; Ignacio I Wistuba; Jonathan M Kurie
High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor.
Cancer research 2005;65(24):11478-85.
2005: Ximing Tang; Hisayuki Shigematsu; B Nebiyou Bekele; Jack A Roth; John D Minna; Waun Ki Hong; Adi F Gazdar; Ignacio I Wistuba
EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients.
Cancer research 2005;65(17):7568-72.
2005: Pablo Uribe; Ignacio I Wistuba; Antonieta Solar; Claudia Balestrini; Maria Luisa Perez-Cotapos; Sergio Gonzalez
Comparative analysis of loss of heterozygosity and microsatellite instability in adult and pediatric melanoma.
The American Journal of dermatopathology 2005;27(4):279-85.
2005: Mauricio Moreno; Fernando Pimentel; Adi F Gazdar; Ignacio I Wistuba; Juan Miquel
TP53 abnormalities are frequent and early events in the sequential pathogenesis of gallbladder carcinoma.
Annals of hepatology 2005;4(3):192-9.
2005: Takao Takahashi; Makoto Suzuki; Hisayuki Shigematsu; Narayan Shivapurkar; Chinyere Echebiri; Masaharu Nomura; Victor Stastny; Meena Augustus; Cheng-Wen Wu; Ignacio I Wistuba; Meltzer Stephen J.; Adi F Gazdar
Aberrant methylation of Reprimo in human malignancies.
International journal of cancer. Journal international du cancer 2005;115(4):503-10.
2005: William D Travis; Kavita Garg; Wilbur A Franklin; Ignacio I Wistuba; Bradley Sabloff; Masayuki Noguchi; Ryutaro Kakinuma; Maureen F Zakowski; Michelle Ginsberg; Robert F Padera; Francine Jacobson; Bruce E Johnson; Fred Hirsch; Elizabeth Brambilla; Douglas B Flieder; Kim R Geisinger; Frederik Thunnisen; Keith Kerr; David Yankelevitz; Teri J Franks; Jeffrey Galvin; Douglas W Henderson; Andrew G Nicholson; Philip S Hasleton; Victor L Roggli; Ming Tsao; Federico Cappuzzo; Madeline Vazquez
Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(14):3279-87.
2005: Bradley S Sabloff; Ignacio I Wistuba; Jeremy J Erasmus
Cystic bronchioloalveolar cell carcinoma.
Journal of thoracic imaging 2005;20(2):110-4.
2005: Marie Wislez; M Loreto Spencer; Julie G Izzo; Denise M Juroske; Kamna Balhara; Dianna D Cody; Roger E Price; Walter N Hittelman; Ignacio I Wistuba; Jonathan M Kurie
Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras.
Cancer research 2005;65(8):3226-35.
2005: Hisayuki Shigematsu; Li Lin; Takao Takahashi; Masaharu Nomura; Makoto Suzuki; Ignacio I Wistuba; Kwun M Fong; Huei Lee; Shinichi Toyooka; Nobuyoshi Shimizu; Takehiko Fujisawa; Ziding Feng; Jack A Roth; Joachim Herz; John D Minna; Adi F Gazdar
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.
Journal of the National Cancer Institute 2005;97(5):339-46.
2005: Hisayuki Shigematsu; Takao Takahashi; Masaharu Nomura; Kuntal Majmudar; Makoto Suzuki; Huei Lee; Ignacio I Wistuba; Kwun M Fong; Shinichi Toyooka; Nobuyoshi Shimizu; Takehiko Fujisawa; John D Minna; Adi F Gazdar
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas.
Cancer research 2005;65(5):1642-6.
2005: Ignacio I Wistuba
Histologic evaluation of bronchial squamous lesions: any role in lung cancer risk assessment?
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(4):1358-60.
2005: Martial Guillaud; Jean C Le Riche; Chris Dawe; Jagoda Korbelik; Andrew J Coldman; Ignacio I Wistuba; In-Won Park; Adi F Gazdar; Stephen Lam; Calum MacAulay
Nuclear morphometry as a biomarker for bronchial intraepithelial neoplasia: correlation with genetic damage and cancer development.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 2005;63(1):34-40.
2004: Ximing Tang; Weiguo Wu; Shi-Yong Sun; Ignacio I Wistuba; Waun Ki Hong; Li Mao
Hypermethylation of the death-associated protein kinase promoter attenuates the sensitivity to TRAIL-induced apoptosis in human non-small cell lung cancer cells.
Molecular cancer research : MCR 2004;2(12):685-91.
2004: Alfredo Velasco; Erick Riquelme; Marcela Schultz; Ignacio I Wistuba; Luis Villarroel; Moon S Koh; Fredrick S Leach
Microsatellite instability and loss of heterozygosity have distinct prognostic value for testicular germ cell tumor recurrence.
Cancer biology & therapy 2004;3(11):1152-8; discussion 1159-61.
2004: David Goldenberg; Eli Rosenbaum; Pedram Argani; Ignacio I Wistuba; David Sidransky; Paul J Thuluvath; Manuel Hidalgo; Joseph A Califano; Anirban Maitra
The V599E BRAF mutation is uncommon in biliary tract cancers.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2004;17(11):1386-91.
2004: Alfredo Velasco; Erick Riquelme; Marcela Schultz; Ignacio I Wistuba; Luis Villarroel; Javier Pizarro; Alejandro Berlin; Michael Ittmann; Moon S Koh; Fredrick S Leach
Mismatch repair gene expression and genetic instability in testicular germ cell tumor.
Cancer biology & therapy 2004;3(10):977-82.
2004: Takao Takahashi; Narayan Shivapurkar; Erick Riquelme; Hisayuki Shigematsu; Jyotsna Reddy; Makoto Suzuki; Kuniharu Miyajima; Xian Zhou; B Nebiyou Bekele; Adi F Gazdar; Ignacio I Wistuba
Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(18 Pt 1):6126-33.
2004: Bradley S Sabloff; Mylene T Truong; Ignacio I Wistuba; Jeremy J Erasmus
Bronchioalveolar cell carcinoma: radiologic appearance and dilemmas in the assessment of response.
Clinical lung cancer 2004;6(2):108-12.
2004: Ignacio I Wistuba; Adi F Gazdar
Gallbladder cancer: lessons from a rare tumour.
Nature reviews. Cancer 2004;4(9):695-706.
2004: Demian A Fullerton; Francisco López; Rodolfo Avendaño; Rodrigo Aparicio; Ignacio I Wistuba
[Atypical presentation of a colorectal carcinoma].
Revista médica de Chile 2004;132(8):985-8.
2004: Moying Tang; Sergio Baez; Martha Pruyas; Alfonso Diaz; Alfonso Calvo; Erick Riquelme; Ignacio I Wistuba
Mitochondrial DNA mutation at the D310 (displacement loop) mononucleotide sequence in the pathogenesis of gallbladder carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(3):1041-6.
2003: Michael G House; Ignacio I Wistuba; Pedram Argani; Mingzhou Guo; Richard D Schulick; Ralph Hruban; James G Herman; Anirban Maitra
Progression of gene hypermethylation in gallstone disease leading to gallbladder cancer.
Annals of surgical oncology 2003;10(8):882-9.
2003: Pablo Uribe; Ignacio I Wistuba; Sergio González
BRAF mutation: a frequent event in benign, atypical, and malignant melanocytic lesions of the skin.
The American Journal of dermatopathology 2003;25(5):365-70.
2003: Ignacio I Wistuba; Carmen Behrens; Jorge Albores-Saavedra; Ruby Delgado; Francisco Lopez; Adi F Gazdar
Distinct K-ras mutation pattern characterizes signet ring cell colorectal carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(10 Pt 1):3615-9.
2003: Moying Tang; Yumai Pires; Marcela Schultz; Ignacio Duarte; Marcela Gallegos; Ignacio I Wistuba
Microsatellite analysis of synchronous and metachronous tumors: a tool for double primary tumor and metastasis assessment.
Diagnostic molecular pathology : the American journal of surgical pathology, part B 2003;12(3):151-9.
2003: Donna E Hansel; Ayman Rahman; Manuel Hidalgo; Paul J Thuluvath; Keith D Lillemoe; Richard Shulick; Ja-Lok Ku; Jae-Gahb Park; Kohje Miyazaki; Raheela Ashfaq; Ignacio I Wistuba; Ram Varma; Lesleyann Hawthorne; Joseph Geradts; Pedram Argani; Anirban Maitra
Identification of novel cellular targets in biliary tract cancers using global gene expression technology.
The American journal of pathology 2003;163(1):217-29.
2003: Ignacio I Wistuba; Adi F Gazdar
Characteristic genetic alterations in lung cancer.
Methods in molecular medicine 2003;74():3-28.
2002: Ignacio I Wistuba; Li Mao; Adi F Gazdar
Smoking molecular damage in bronchial epithelium.
Oncogene 2002;21(48):7298-306.
2002: Ignacio I Wistuba; Anirban Maitra; R Carrasco; Moying Tang; P Troncoso; J D Minna; Adi F Gazdar
High resolution chromosome 3p, 8p, 9q and 22q allelotyping analysis in the pathogenesis of gallbladder carcinoma.
British journal of cancer 2002;87(4):432-40.
2002: Shinichi Toyooka; Yasuro Fukuyama; Ignacio I Wistuba; Melvyn S Tockman; John D Minna; Adi F Gazdar
Differential expression of FEZ1/LZTS1 gene in lung cancers and their cell cultures.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2292-7.
2002: Ignacio I Wistuba; Raheela Ashfaq; Anirban Maitra; Hector Alvarez; Erick Riquelme; Adi F Gazdar
Fragile histidine triad gene abnormalities in the pathogenesis of gallbladder carcinoma.
The American journal of pathology 2002;160(6):2073-9.
2002: Jiaoti Huang; Carmen Behrens; Ignacio I Wistuba; Adi F Gazdar; Jaishree Jagirdar
Clonality of combined tumors.
Archives of pathology & laboratory medicine 2002;126(4):437-41.
2001: Ignacio I Wistuba
[Molecular pathology: applications of molecular biology in pathological anatomy].
Revista médica de Chile 2001;129(7):791-804.
2001: Anirban Maitra; Ignacio I Wistuba; C Washington; Arvind K Virmani; Raheela Ashfaq; Sara Milchgrub; Adi F Gazdar; John D Minna
High-resolution chromosome 3p allelotyping of breast carcinomas and precursor lesions demonstrates frequent loss of heterozygosity and a discontinuous pattern of allele loss.
The American journal of pathology 2001;159(1):119-30.
2001: Anirban Maitra; Ignacio I Wistuba; Adi F Gazdar
Microdissection and the study of cancer pathways.
Current molecular medicine 2001;1(1):153-62.
2000: Sabine Zöchbauer-Müller; Ignacio I Wistuba; J D Minna; Adi F Gazdar
Fragile histidine triad (FHIT) gene abnormalities in lung cancer.
Clinical lung cancer 2000;2(2):141-5.
2000: Ignacio I Wistuba; Gail Tomlinson; C Behrens; Arvind K Virmani; Joseph Geradts; Joanne L Blum; John D Minna; Adi F Gazdar
Two identical triplet sisters carrying a germline BRCA1 gene mutation acquire very similar breast cancer somatic mutations at multiple other sites throughout the genome.
Genes, chromosomes & cancer 2000;28(4):359-69.
2000: Ignacio I Wistuba; J Berry; Carmen Behrens; Anirban Maitra; Narayan Shivapurkar; Sara Milchgrub; Bruce Mackay; John D Minna; Adi F Gazdar
Molecular changes in the bronchial epithelium of patients with small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(7):2604-10.
2000: Ignacio I Wistuba; Carmen Behrens; Arvind K Virmani; G Mele; Sara Milchgrub; Luc Girard; John W Fondon; Harold R Garner; B McKay; Farida Latif; Michael I Lerman; Stephen Lam; Adi F Gazdar; John D Minna
High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints.
Cancer research 2000;60(7):1949-60.
2000: Narayan Shivapurkar; Thorsten Wiethege; Ignacio I Wistuba; Sara Milchgrub; KM Muller; A F Gazdar
Presence of simian virus 40 sequences in malignant pleural, peritoneal and noninvasive mesotheliomas.
International journal of cancer. Journal international du cancer 2000;85(5):743-5.
2000: Sara Milchgrub; Ignacio I Wistuba; B K Kim; Cynthia Rutherford; J Urban; Ponciano D Cruz; Adi F Gazdar
Molecular identification of metastatic cancer to the skin using laser capture microdissection: a case report.
Cancer 2000;88(4):749-54.
2000: Ignacio I Wistuba; Adi F Gazdar
Molecular pathology of lung cancer.
Verhandlungen der Deutschen Gesellschaft für Pathologie 2000;84():96-105.
1999: David M Euhus; Anirban Maitra; Ignacio I Wistuba; Raheela Ashfaq; A Alberts; D Gibbons; Adi F Gazdar
Use of archival fine-needle aspirates for the allelotyping of tumors.
Cancer 1999;87(6):372-9.
1999: Anirban Maitra; Fattaneh A Tavassoli; Jorge Albores-Saavedra; Carmen Behrens; Ignacio I Wistuba; D Bryant; Arthur G Weinberg; Beverly B Rogers; M Hossein Saboorian; Adi F Gazdar
Molecular abnormalities associated with secretory carcinomas of the breast.
Human pathology 1999;30(12):1435-40.
1999: Narayan Shivapurkar; Thorsten Wiethege; Ignacio I Wistuba; E Salomon; Sara Milchgrub; KM Muller; A Churg; Harvey I Pass; Adi F Gazdar
Presence of simian virus 40 sequences in malignant mesotheliomas and mesothelial cell proliferations.
Journal of cellular biochemistry 1999;76(2):181-8.
1999: I W Park; Ignacio I Wistuba; Anirban Maitra; Sara Milchgrub; Arvind K Virmani; John D Minna; Adi F Gazdar
Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer.
Journal of the National Cancer Institute 1999;91(21):1863-8.
1999: Ignacio I Wistuba; S Syed; Carmen Behrens; M Duong; Sara Milchgrub; Carolyn Y Muller; Jaishree Jagirdar; Adi F Gazdar
Comparison of molecular changes in cervical intraepithelial neoplasia in HIV-positive and HIV-indeterminate subjects.
Gynecologic oncology 1999;74(3):519-26.
1999: Anirban Maitra; Ignacio I Wistuba; D Gibbons; Adi F Gazdar; Jorge Albores-Saavedra
Allelic losses at chromosome 3p are seen in human papilloma virus 16 associated transitional cell carcinoma of the cervix.
Gynecologic oncology 1999;74(3):361-8.
1999: Narayan Shivapurkar; S Sood; Ignacio I Wistuba; Arvind K Virmani; Anirban Maitra; Sara Milchgrub; John D Minna; Adi F Gazdar
Multiple regions of chromosome 4 demonstrating allelic losses in breast carcinomas.
Cancer research 1999;59(15):3576-80.
1999: Ignacio I Wistuba; C Behrens; Adi F Gazdar
Pathogenesis of non-AIDS-defining cancers: a review.
AIDS patient care and STDs 1999;13(7):415-26.
1999: L C Flowers; Ignacio I Wistuba; J Scurry; Carolyn Y Muller; Raheela Ashfaq; David S Miller; John D Minna; Adi F Gazdar
Genetic changes during the multistage pathogenesis of human papillomavirus positive and negative vulvar carcinomas.
Journal of the Society for Gynecologic Investigation 1999;6(4):213-21.
1999: DM Ramnani; Ignacio I Wistuba; Carmen Behrens; Adi F Gazdar; Leslie H Sobin; Jorge Albores-Saavedra
K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix.
Cancer 1999;86(1):14-21.
1999: Ignacio I Wistuba; D Bryant; Carmen Behrens; Sara Milchgrub; Arvind K Virmani; Raheela Ashfaq; John D Minna; Adi F Gazdar
Comparison of features of human lung cancer cell lines and their corresponding tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(5):991-1000.
1999: David M Euhus; Anirban Maitra; Ignacio I Wistuba; A Alberts; Jorge Albores-Saavedra; Adi F Gazdar
Loss of heterozygosity at 3p in benign lesions preceding invasive breast cancer.
The Journal of surgical research 1999;83(1):13-8.
1999: Ignacio I Wistuba; Carmen Behrens; Arvind K Virmani; Sara Milchgrub; S Syed; Stephen Lam; Bruce Mackay; John D Minna; Adi F Gazdar
Allelic losses at chromosome 8p21-23 are early and frequent events in the pathogenesis of lung cancer.
Cancer research 1999;59(8):1973-9.
1999: N Onuki; Ignacio I Wistuba; William D Travis; Arvind K Virmani; K Yashima; Elizabeth Brambilla; P Hasleton; Adi F Gazdar
Genetic changes in the spectrum of neuroendocrine lung tumors.
Cancer 1999;85(3):600-7.
1999: Ignacio I Wistuba; Carmen Behrens; Sara Milchgrub; D Bryant; Jaclyn Y Hung; John D Minna; Adi F Gazdar
Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma.
Oncogene 1999;18(3):643-50.
1999: Ignacio I Wistuba; Jorge Albores-Saavedra
Genetic abnormalities involved in the pathogenesis of gallbladder carcinoma.
Journal of hepato-biliary-pancreatic surgery 1999;6(3):237-44.
1999: Ignacio I Wistuba; Juan Miquel; Adi F Gazdar; Jorge Albores-Saavedra
Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas.
Human pathology 1999;30(1):21-5.
1999: Narayan Shivapurkar; Arvind K Virmani; Ignacio I Wistuba; Sara Milchgrub; Bruce Mackay; John D Minna; Adi F Gazdar
Deletions of chromosome 4 at multiple sites are frequent in malignant mesothelioma and small cell lung carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(1):17-23.
1999: Ignacio I Wistuba; B Thomas; Carmen Behrens; N Onuki; Guy Lindberg; Jorge Albores-Saavedra; Adi F Gazdar
Molecular abnormalities associated with endocrine tumors of the uterine cervix.
Gynecologic oncology 1999;72(1):3-9.
1998: Adi F Gazdar; V Kurvari; Arvind K Virmani; Lauren S Gollahon; Masahiro Sakaguchi; M Westerfield; DR Kodagoda; V Stasny; H Thomas Cunningham; Ignacio I Wistuba; Gail Tomlinson; Vijay S Tonk; Raheela Ashfaq; A Marilyn Leitch; John D Minna; Jerry W Shay
Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer.
International journal of cancer. Journal international du cancer 1998;78(6):766-74.
1998: Ignacio I Wistuba; Carmen Behrens; Sara Milchgrub; S Syed; M Ahmadian; Arvind K Virmani; V Kurvari; T H Cunningham; Raheela Ashfaq; John D Minna; Adi F Gazdar
Comparison of features of human breast cancer cell lines and their corresponding tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(12):2931-8.
1998: Eva Forgacs; EJ Biesterveld; Yoshitaka Sekido; Kwun Fong; Sabeeha Muneer; Ignacio I Wistuba; Sara Milchgrub; Ruth I Brezinschek; Arvind K Virmani; Adi F Gazdar; John D Minna
Mutation analysis of the PTEN/MMAC1 gene in lung cancer.
Oncogene 1998;17(12):1557-65.
1998: Gail Tomlinson; Tina T-L Chen; Victor Stastny; Arvind K Virmani; M A Spillman; Vijay S Tonk; Joanne L Blum; N R Schneider; Ignacio I Wistuba; Jerry W Shay; John D Minna; Adi F Gazdar
Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier.
Cancer research 1998;58(15):3237-42.
1998: Yoshitaka Sekido; M Ahmadian; Ignacio I Wistuba; Farida Latif; SA Bader; Ming-Hui Wei; Fuh-Mei Duh; Adi F Gazdar; Michael I Lerman; John D Minna
Cloning of a breast cancer homozygous deletion junction narrows the region of search for a 3p21.3 tumor suppressor gene.
Oncogene 1998;16(24):3151-7.
1998: Ignacio I Wistuba; Carmen Behrens; Sara Milchgrub; Arvind K Virmani; Jaishree Jagirdar; B Thomas; H L Ioachim; L A Litzky; E M Brambilla; John D Minna; Adi F Gazdar
Comparison of molecular changes in lung cancers in HIV-positive and HIV-indeterminate subjects.
JAMA : the journal of the American Medical Association 1998;279(19):1554-9.
1998: Carolyn Y Muller; JD O'Boyle; Kwun M Fong; Ignacio I Wistuba; EJ Biesterveld; M Ahmadian; David S Miller; Adi F Gazdar; John D Minna
Abnormalities of fragile histidine triad genomic and complementary DNAs in cervical cancer: association with human papillomavirus type.
Journal of the National Cancer Institute 1998;90(6):433-9.
1997: Ignacio I Wistuba; Stephen Lam; Carmen Behrens; Arvind K Virmani; Kwun M Fong; J LeRiche; Jonathan M Samet; sudhir srivastava; John D Minna; Adi F Gazdar
Molecular damage in the bronchial epithelium of current and former smokers.
Journal of the National Cancer Institute 1997;89(18):1366-73.
1997: M Ahmadian; Ignacio I Wistuba; Kwun M Fong; Carmen Behrens; DR Kodagoda; M Hossein Saboorian; Jerry W Shay; Gail Tomlinson; J Blum; John D Minna; Adi F Gazdar
Analysis of the FHIT gene and FRA3B region in sporadic breast cancer, preneoplastic lesions, and familial breast cancer probands.
Cancer research 1997;57(17):3664-8.
1997: Ignacio I Wistuba; F D Montellano; Sara Milchgrub; Arvind K Virmani; Carmen Behrens; Hong Chen; M Ahmadian; Jan Anthony Nowak; C Muller; John D Minna; Adi F Gazdar
Deletions of chromosome 3p are frequent and early events in the pathogenesis of uterine cervical carcinoma.
Cancer research 1997;57(15):3154-8.
1997: K Yashima; L A Litzky; L Kaiser; T Rogers; Stephen Lam; Ignacio I Wistuba; Sara Milchgrub; sudhir srivastava; M A Piatyszek; Jerry W Shay; Adi F Gazdar
Telomerase expression in respiratory epithelium during the multistage pathogenesis of lung carcinomas.
Cancer research 1997;57(12):2373-7.
1997: Kwun M Fong; EJ Biesterveld; Arvind K Virmani; Ignacio I Wistuba; Yoshitaka Sekido; SA Bader; M Ahmadian; ST Ong; Feyruz V Rassool; Paul V Zimmerman; G Giaccone; Adi F Gazdar; John D Minna
FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.
Cancer research 1997;57(11):2256-67.
1996: Y Yamamoto; Arvind K Virmani; Ignacio I Wistuba; D McIntire; F Vuitch; Jorge Albores-Saavedra; Adi F Gazdar
Loss of heterozygosity and microsatellite alterations in p53 and RB genes in adenoid cystic carcinoma of the salivary glands.
Human pathology 1996;27(11):1204-10.
1995: Ignacio I Wistuba; K Sugio; Jaclyn Y Hung; Y Kishimoto; Arvind K Virmani; I Roa; Jorge Albores-Saavedra; Adi F Gazdar
Allele-specific mutations involved in the pathogenesis of endemic gallbladder carcinoma in Chile.
Cancer research 1995;55(12):2511-5.