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Joan Wither

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E Pau; Nan-Hua Chang; C Loh; G E S Minty; Joan E Wither
Identification of a lupus-susceptibility locus leading to impaired clearance of apoptotic debris on New Zealand Black chromosome 13.
Evelyn Pau; Yui-Ho Cheung; Ginette Lajoie; Christina Loh; Joan E Wither
TLR tolerance reduces IFN-alpha production despite plasmacytoid dendritic cell expansion and anti-nuclear antibodies in NZB bicongenic mice.
Y-H Cheung; C Landolt-Marticorena; Ginette Lajoie; Joan E Wither
The lupus phenotype in B6.NZBc1 congenic mice reflects interactions between multiple susceptibility loci and a suppressor locus.

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All Publications

2013: E Pau; Nan-Hua Chang; C Loh; G E S Minty; Joan E Wither
Identification of a lupus-susceptibility locus leading to impaired clearance of apoptotic debris on New Zealand Black chromosome 13.
Genes and immunity 2013;14(3):154-61.
2012: Evelyn Pau; Yui-Ho Cheung; Ginette Lajoie; Christina Loh; Joan E Wither
TLR tolerance reduces IFN-alpha production despite plasmacytoid dendritic cell expansion and anti-nuclear antibodies in NZB bicongenic mice.
PloS one 2012;7(5):e36761.
2011: Y-H Cheung; C Landolt-Marticorena; Ginette Lajoie; Joan E Wither
The lupus phenotype in B6.NZBc1 congenic mice reflects interactions between multiple susceptibility loci and a suppressor locus.
Genes and immunity 2011;12(4):251-62.
2011: Christina Loh; Evelyn Pau; Ginette Lajoie; Timothy T Li; Yuriy Baglaenko; Yui-Ho Cheung; Nan-Hua Chang; Joan E Wither
Epistatic suppression of fatal autoimmunity in New Zealand black bicongenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(10):5845-53.
2011: Evelyn Pau; Nan-Hua Chang; Christina Loh; Ginette Lajoie; Joan E Wither
Abrogation of pathogenic IgG autoantibody production in CD40L gene-deleted lupus-prone New Zealand Black mice.
Clinical immunology (Orlando, Fla.) 2011;139(2):215-27.
2011: Carolina Landolt-Marticorena; Robert Wither; Heather Reich; Andrew Herzenberg; James Scholey; Dafna D Gladman; Murray B Urowitz; Paul R Fortin; Joan E Wither
Increased expression of B cell activation factor supports the abnormal expansion of transitional B cells in systemic lupus erythematosus.
The Journal of rheumatology 2011;38(4):642-51.
2011: Elaheh Aghdassi; Wendy Zhang; Yvan St-Pierre; Ann E Clarke; Stacey Morrison; Valentina Peeva; Carolina Landolt-Marticorena; Jiandong Su; Heather Reich; James Scholey; Andrew Herzenberg; Janet E Pope; Christine Peschken; Joan E Wither; Paul R Fortin
Healthcare cost and loss of productivity in a Canadian population of patients with and without lupus nephritis.
The Journal of rheumatology 2011;38(4):658-66.
2011: Christina Loh; Evelyn Pau; Nan-Hua Chang; Joan E Wither
An intrinsic B-cell defect supports autoimmunity in New Zealand black chromosome 13 congenic mice.
European journal of immunology 2011;41(2):527-36.
2010: Lang-Jing Zhu; Carolina Landolt-Marticorena; Timothy Li; Xiao Yang; Xue-Qing Yu; Dafna D Gladman; Murray B Urowitz; Paul R Fortin; Joan E Wither
Altered expression of TNF-alpha signaling pathway proteins in systemic lupus erythematosus.
The Journal of rheumatology 2010;37(8):1658-66.
2010: Nan-Hua Chang; Robert D Inman; John E Dick; Joan E Wither
Bone marrow-derived human hematopoietic stem cells engraft NOD/SCID mice and traffic appropriately to an inflammatory stimulus in the joint.
The Journal of rheumatology 2010;37(3):496-502.
2010: Nan-Hua Chang; Yui-Ho Cheung; Christina Loh; Evelyn Pau; Valerie Roy; Yong-Chun Cai; Joan E Wither
B cell activating factor (BAFF) and T cells cooperate to breach B cell tolerance in lupus-prone New Zealand Black (NZB) mice.
PloS one 2010;5(7):e11691.
2009: Alexandra-Chloé Villani; Mathieu Lemire; Geneviève Fortin; Edouard Louis; Mark S Silverberg; Catherine Collette; Nobuyasu Baba; Cecile Libioulle; Jacques Belaiche; Alain Bitton; Daniel Gaudet; Albert Cohen; Diane Langelier; Paul R Fortin; Joan E Wither; Marika Sarfati; Paul Rutgeerts; John D Rioux; Severine Vermeire; Thomas J Hudson; Denis Franchimont
Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.
Nature genetics 2009;41(1):71-6.
2008: Robert R Graham; Chris Cotsapas; Leela Davies; Rachel Hackett; Christopher J Lessard; Joanlise M Leon; Noël P Burtt; Candace Guiducci; Melissa Parkin; Casey Gates; Robert M Plenge; timothy wayne behrens; Joan E Wither; John D Rioux; Paul R Fortin; Deborah Cunninghame Graham; Andrew K Wong; Timothy J Vyse; Mark J Daly; David Altshuler; Kathy L Moser; Patrick M Gaffney
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
Nature genetics 2008;40(9):1059-61.
2008: Nan-Hua Chang; Tamara McKenzie; Gabriel Bonventi; Carolina Landolt-Marticorena; Paul R Fortin; Dafna Gladman; Murray Urowitz; Joan E Wither
Expanded population of activated antigen-engaged cells within the naive B cell compartment of patients with systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):1276-84.
2007: Valerie Roy; Gabriel Bonventi; Yongchun Cai; Ralph MacLeod; Joan E Wither
Immune mechanisms leading to abnormal B cell selection and activation in New Zealand Black mice.
European journal of immunology 2007;37(9):2645-56.
2007: Christina Loh; Yong-Chun Cai; Gabriel Bonventi; Ginette Lajoie; Ralph MacLeod; Joan E Wither
Dissociation of the genetic loci leading to b1a and NKT cell expansions from autoantibody production and renal disease in B6 mice with an introgressed New Zealand Black chromosome 4 interval.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1608-17.
2006: Jerrold S Levine; Rebecca Subang; Samih H Nasr; Sylvie Fournier; Ginette Lajoie; Joan E Wither; Joyce Rauch
Immunization with an apoptotic cell-binding protein recapitulates the nephritis and sequential autoantibody emergence of systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6504-16.
2006: Laurie L Baggio; Dianne Holland; Joan E Wither; Daniel J Drucker
Lymphocytic infiltration and immune activation in metallothionein promoter-exendin-4 (MT-Exendin) transgenic mice.
Diabetes 2006;55(6):1562-70.
2005: Yui-Ho Cheung; Nan-Hua Chang; Yong-Chun Cai; Gabriel Bonventi; Ralph MacLeod; Joan E Wither
Functional interplay between intrinsic B and T cell defects leads to amplification of autoimmune disease in New Zealand black chromosome 1 congenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(12):8154-64.
2005: Valerie Roy; Nan-Hua Chang; Yongchun Cai; Gabriel Bonventi; Joan E Wither
Aberrant IgM signaling promotes survival of transitional T1 B cells and prevents tolerance induction in lupus-prone New Zealand black mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7363-71.
2005: Joan E Wither; Christina Loh; Ginette Lajoie; Svinda Heinrichs; Yong-Chun Cai; Gabriel Bonventi; Ralph MacLeod
Colocalization of expansion of the splenic marginal zone population with abnormal B cell activation and autoantibody production in B6 mice with an introgressed New Zealand Black chromosome 13 interval.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4309-19.
2004: Shigeru Sugiyama; Masako Kohyama; Masayuki Oda; Takachika Azuma; Joan E Wither; Nobumichi Hozumi
Molecular basis of antigen recognition by insulin specific T cell receptor.
Immunology letters 2004;91(2-3):133-9.
2004: Nan-Hua Chang; Ralph MacLeod; Joan E Wither
Autoreactive B cells in lupus-prone New Zealand black mice exhibit aberrant survival and proliferation in the presence of self-antigen in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1553-60.
2003: Joan E Wither; Ginette Lajoie; Svinda Heinrichs; Yong-Chun Cai; Nan Chang; Amelia Ciofani; Yui-Ho Cheung; Ralph MacLeod
Functional dissection of lupus susceptibility loci on the New Zealand black mouse chromosome 1: evidence for independent genetic loci affecting T and B cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1697-706.
2000: Joan E Wither; B Vukusic
T-cell tolerance induction is normal in the (NZB x NZW)F1 murine model of systemic lupus erythematosus.
Immunology 2000;99(3):345-51.
2000: Joan E Wither; A D Paterson; B Vukusic
Genetic dissection of B cell traits in New Zealand black mice. The expanded population of B cells expressing up-regulated costimulatory molecules shows linkage to Nba2.
European journal of immunology 2000;30(2):356-65.
2000: Joan E Wither; Valerie Roy; L A Brennan
Activated B cells express increased levels of costimulatory molecules in young autoimmune NZB and (NZB x NZW)F(1) mice.
Clinical immunology (Orlando, Fla.) 2000;94(1):51-63.
1999: Joan E Wither; B Vukusic
The orientation and nature of the interaction between beef insulin-specific TCRs and the insulin/class II MHC complex.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):2113-22.
1998: Joan E Wither; B Vukusic
Autoimmunity develops in lupus-prone NZB mice despite normal T cell tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4555-62.
1998: Y Wu; MJ Nadler; L A Brennan; G D Gish; John Francis Timms; Noemi Fusaki; J Jongstra-Bilen; N Tada; T Pawson; Joan E Wither; Benjamin G Neel; Nobumichi Hozumi
The B-cell transmembrane protein CD72 binds to and is an in vivo substrate of the protein tyrosine phosphatase SHP-1.
Current biology : CB 1998;8(18):1009-17.
1998: A Carpentier; Joan E Wither; B Vukusic; K Lawday; A H Boss; G F Lewis
An epitaph for sulfated insulin: immunologic profile of the last patients as they are switched from sulfated beef to human insulin.
Diabetes care 1998;21(9):1571-2.
1998: Proton Rahman; Dafna D Gladman; Joan E Wither; M D Silver
Coexistence of Fabry's disease and systemic lupus erythematosus.
Clinical and experimental rheumatology 1998;16(4):475-8.
1997: Jenny Jongstra-Bilen; B Vukusic; Kata Boras; Joan E Wither
Resting B cells from autoimmune lupus-prone New Zealand Black and (New Zealand Black x New Zealand White)F1 mice are hyper-responsive to T cell-derived stimuli.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):5810-20.
1996: L Poplonski; B Vukusic; J Pawling; S Clapoff; J Roder; Nobumichi Hozumi; Joan E Wither
Tolerance is overcome in beef insulin-transgenic mice by activation of low-affinity autoreactive T cells.
European journal of immunology 1996;26(3):601-9.
1995: B Vukusic; L Poplonski; L Phillips; J Pawling; Terry L Delovitch; Nobumichi Hozumi; Joan E Wither
Both MHC and background gene heterozygosity alter T cell receptor repertoire selection in an antigen-specific response.
Molecular immunology 1995;32(17-18):1355-67.
1991: Joan E Wither; J Pawling; L Phillips; Terry L Delovitch; Nobumichi Hozumi
Amino acid residues in the T cell receptor CDR3 determine the antigenic reactivity patterns of insulin-reactive hybridomas.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(10):3513-22.
1990: J Kang; Joan E Wither; Nobumichi Hozumi
Long-term expression of a T-cell receptor beta-chain gene in mice reconstituted with retrovirus-infected hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9803-7.