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Dominic Withers

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Lazaros C Foukas; Wayne Pearce; Sara Sancho; Khaled Ali; Lucia Bettedi; Benoit Bilanges; Dominic J Withers; Bart Vanhaesebroeck
Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism.
William R Scott; Dominic J Withers; Ahmed Yousseif; Chloé Amouyal; Fabrizio Andreelli; Keval Chandarana; Agharul I Choudhury; Cigdem Gelegen; Efthimia Karra; Rachel L Batterham
Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice.
C Gelegen; C B Hyde; Elaine E Irvine; A B Leiter; S E Sloan; Dominic J Withers; K Chandarana; Agharul I Choudhury; Marc Claret; I M Evans; Hind Al-Qassab; Fabrizio Andreelli; Rachel L Batterham
Regulation of hindbrain Pyy expression by acute food deprivation, prolonged caloric restriction, and weight loss surgery in mice.

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All Publications

2013: Lazaros C Foukas; Wayne Pearce; Sara Sancho; Khaled Ali; Lucia Bettedi; Benoit Bilanges; Dominic J Withers; Bart Vanhaesebroeck
Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism.
EMBO molecular medicine 2013;5(4):563-71.
2013: William R Scott; Dominic J Withers; Ahmed Yousseif; Chloé Amouyal; Fabrizio Andreelli; Keval Chandarana; Agharul I Choudhury; Cigdem Gelegen; Efthimia Karra; Rachel L Batterham
Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice.
PloS one 2013;8(3):e59407.
2012: C Gelegen; C B Hyde; Elaine E Irvine; A B Leiter; S E Sloan; Dominic J Withers; K Chandarana; Agharul I Choudhury; Marc Claret; I M Evans; Hind Al-Qassab; Fabrizio Andreelli; Rachel L Batterham
Regulation of hindbrain Pyy expression by acute food deprivation, prolonged caloric restriction, and weight loss surgery in mice.
American journal of physiology. Endocrinology and metabolism 2012;303(5):E659-68.
2012: Anisha Wijeyesekera; Richard H Barton; Elaine Holmes; Jeremy K Nicholson; Colin Selman; Dominic J Withers
Metabotyping of long-lived mice using 1H NMR spectroscopy.
Journal of proteome research 2012;11(4):2224-35.
2012: Derek A Costello; peter giese; Elaine E Irvine; Hind Al-Qassab; Agharul I Choudhury; Marc Claret; Florian Plattner; Dominic J Withers; Paola Pedarzani
Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity.
PloS one 2012;7(2):e31124.
2011: Elaine E Irvine; Laura Drinkwater; Kasia Radwanska; Hind Al-Qassab; Mark A Smith; Melissa O'Brien; Catherine Kielar; Agharul I Choudhury; Stefan Krauss; Jonathan D Cooper; Dominic J Withers; peter giese
Insulin receptor substrate 2 is a negative regulator of memory formation.
Learning & memory (Cold Spring Harbor, N.Y.) 2011;18(6):375-83.
2011: Keval Chandarana; Cigdem Gelegen; Efthimia Karra; Agharul I Choudhury; Megan E Drew; Veronique Fauveau; Benoit Viollet; Fabrizio Andreelli; Dominic J Withers; Rachel L Batterham
Diet and gastrointestinal bypass-induced weight loss: the roles of ghrelin and peptide YY.
Diabetes 2011;60(3):810-8.
2011: Marc Claret; Mark A Smith; Claude Knauf; Hind Al-Qassab; Angela Woods; Amanda Heslegrave; Kaisa Piipari; Julian J Emmanuel; André Colom; Philippe Valet; Patrice D Cani; Ghazala Begum; Anne White; Phillip Mucket; Marco Peters; Keiko Mizuno; Rachel L Batterham; peter giese; Alan Ashworth; Remy Burcelin; Michael L Ashford; David Carling; Dominic J Withers
Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice.
Diabetes 2011;60(3):735-45.
2010: Craig Beall; Kaisa Piipari; Hind Al-Qassab; Mark A Smith; Nadeene Parker; David Carling; Benoit Viollet; Dominic J Withers; Michael L J Ashford
Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.
The Biochemical journal 2010;429(2):323-33.
2010: Cathy Slack; Christian Werz; Daniela Wieser; Nazif Alic; Andrea Foley; Hugo Stocker; Dominic J Withers; Janet M Thornton; Ernst Hafen; Linda Partridge
Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk.
PLoS genetics 2010;6(3):e1000881.
2010: Xinzhong Li; Peter A Thomason; Dominic J Withers; James Scott
Bio-informatics analysis of a gene co-expression module in adipose tissue containing the diet-responsive gene Nnat.
BMC systems biology 2010;4():175.
2010: Lazaros C Foukas; Dominic J Withers
Phosphoinositide signalling pathways in metabolic regulation.
Current topics in microbiology and immunology 2010;346():115-41.
2009: Hind Al-Qassab; Mark A Smith; Elaine E Irvine; Julie Guillermet-Guibert; Marc Claret; Agharul I Choudhury; Colin Selman; Kaisa Piipari; Melanie Clements; Steven Lingard; Keval Chandarana; Jimmy D Bell; Gregory S Barsh; Andrew J H Smith; Rachel L Batterham; Michael L J Ashford; Bart Vanhaesebroeck; Dominic J Withers
Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons.
Cell metabolism 2009;10(5):343-54.
2009: Colin Selman; Jennifer M A Tullet; Daniela Wieser; Elaine Irvine; Steven J Lingard; Agharul I Choudhury; Marc Claret; Hind Al-Qassab; Danielle Carmignac; Faruk Ramadani; Angela Woods; Iain C A Robinson; Eugene Schuster; Rachel L Batterham; Sara C Kozma; George Thomas; David Carling; Klaus Okkenhaug; Janet M Thornton; Linda Partridge; David Gems; Dominic J Withers
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Science (New York, N.Y.) 2009;326(5949):140-4.
2009: Richard Killick; Georgie Scales; Karelle Leroy; Mirsada Causevic; Claudie Hooper; Elaine E Irvine; Agharul I Choudhury; Laura Drinkwater; Fiona Kerr; Hind Al-Qassab; John Stephenson; Zehra Yilmaz; peter giese; Jean-Pierre Brion; Dominic J Withers; Simon Lovestone
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice.
Biochemical and biophysical research communications 2009;386(1):257-62.
2009: K Hisadome; Mark A Smith; A I Choudhury; M Claret; Dominic J Withers; Michael L J Ashford
5-HT inhibition of rat insulin 2 promoter Cre recombinase transgene and proopiomelanocortin neuron excitability in the mouse arcuate nucleus.
Neuroscience 2009;159(1):83-93.
2009: James Cantley; Colin Selman; Deepa Shukla; Andrey Y Abramov; Frauke Forstreuter; Miguel A Esteban; Marc Claret; Steven J Lingard; Melanie Clements; Sarah K Harten; Henry Asare-Anane; Rachel L Batterham; Pedro L Herrera; Shanta J Persaud; Michael R Duchen; Patrick H Maxwell; Dominic J Withers
Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.
The Journal of clinical investigation 2009;119(1):125-35.
2008: Colin Selman; Steven Lingard; David Gems; Linda Partridge; Dominic J Withers
Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis".
Science (New York, N.Y.) 2008;320(5879):1012; author reply 1012.
2008: Colin Selman; Steven J Lingard; Agharul I Choudhury; Rachel L Batterham; Marc Claret; Melanie Clements; Faruk Ramadani; Klaus Okkenhaug; Eugene Schuster; Eric Blanc; Matthew D W Piper; Hind Al-Qassab; John R Speakman; Danielle Carmignac; Iain C A F Robinson; Janet M Thornton; David Gems; Linda Partridge; Dominic J Withers
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(3):807-18.
2007: Rachel L Batterham; Dominic H Ffytche; J Miranda Rosenthal; Fernando O Zelaya; Gareth Barker; Dominic J Withers; steven williams
PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans.
Nature 2007;450(7166):106-9.
2007: Marc Claret; Mark A Smith; Rachel L Batterham; Colin Selman; Agharul I Choudhury; Lee G D Fryer; Melanie Clements; Hind Al-Qassab; Helen Heffron; Allison W Xu; John R Speakman; Gregory S Barsh; Benoit Viollet; Sophie Vaulont; Michael L J Ashford; David Carling; Dominic J Withers
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.
The Journal of clinical investigation 2007;117(8):2325-36.
2007: J Cantley; Agharul I Choudhury; Henry Asare-Anane; Colin Selman; Steven J Lingard; Helen Heffron; P Herrera; Shanta J Persaud; Dominic J Withers
Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice.
Diabetologia 2007;50(6):1248-56.
2007: Irina Neganova; Hind Al-Qassab; Helen Heffron; Colin Selman; Agharul I Choudhury; Steven J Lingard; Ivan Diakonov; Michael Patterson; Mohammad A Ghatei; Stephen R Bloom; Stephen Franks; Ilpo Huhtaniemi; Kate Hardy; Dominic J Withers
Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse.
Biology of reproduction 2007;76(6):1045-53.
2007: Mark A Smith; Kazunari Hisadome; Hind Al-Qassab; Helen Heffron; Dominic J Withers; Michael L J Ashford
Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances.
The Journal of physiology 2007;578(Pt 2):425-38.
2007: Joshua J McElwee; Eugene Schuster; Eric Blanc; Matthew D W Piper; James H Thomas; Dhaval S Patel; Colin Selman; Dominic J Withers; Janet M Thornton; Linda Partridge; David Gems
Evolutionary conservation of regulated longevity assurance mechanisms.
Genome biology 2007;8(7):R132.
2006: Colin Selman; Nicola D Kerrison; Anisha Cooray; Matthew D W Piper; Steven J Lingard; Richard H Barton; Eugene Schuster; Eric Blanc; David Gems; Jeremy K Nicholson; Janet M Thornton; Linda Partridge; Dominic J Withers
Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice.
Physiological genomics 2006;27(3):187-200.
2006: Rachel L Batterham; Helen Heffron; Saloni Kapoor; Joanna E Chivers; Keval Chandarana; Herbert Herzog; Carel W le Roux; E Louise Thomas; Jimmy D Bell; Dominic J Withers
Critical role for peptide YY in protein-mediated satiation and body-weight regulation.
Cell metabolism 2006;4(3):223-33.
2006: Lazaros C Foukas; Marc Claret; Wayne Pearce; Klaus Okkenhaug; Stephen Meek; Emma Peskett; Sara Sancho; Andrew J H Smith; Dominic J Withers; Bart Vanhaesebroeck
Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.
Nature 2006;441(7091):366-70.
2006: Marcus Simmgen; Claude Knauf; M Lopez; Agharul I Choudhury; M Charalambous; J Cantley; David Bedford; Marc Claret; Miguel A Iglesias; Helen Heffron; Patrice Cani; Antonio Vidal-Puig; Rémy Burcelin; Dominic J Withers
Liver-specific deletion of insulin receptor substrate 2 does not impair hepatic glucose and lipid metabolism in mice.
Diabetologia 2006;49(3):552-61.
2005: Agharul I Choudhury; Helen Heffron; Mark A Smith; Hind Al-Qassab; Allison W Xu; Colin Selman; Marcus Simmgen; Melanie Clements; Marc Claret; Gavin MacColl; David Bedford; Kazunari Hisadome; Ivan Diakonov; Vazira Moosajee; Jimmy D Bell; John R Speakman; Rachel L Batterham; Gregory S Barsh; Michael L J Ashford; Dominic J Withers
The role of insulin receptor substrate 2 in hypothalamic and beta cell function.
The Journal of clinical investigation 2005;115(4):940-50.
2005: Linda Partridge; David Gems; Dominic J Withers
Sex and death: what is the connection?
Cell 2005;120(4):461-72.
2005: Susan J Broughton; Matthew D W Piper; Tomoatsu Ikeya; Timothy M Bass; Jake Jacobson; Yasmine Driege; Pedro Martinez; Ernst Hafen; Dominic J Withers; Sally J Leevers; Linda Partridge
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):3105-10.
2003: Rachel L Batterham; Mark A Cohen; Sandra M Ellis; Carel W le Roux; Dominic J Withers; Gary S Frost; Mohammad A Ghatei; Stephen R Bloom
Inhibition of food intake in obese subjects by peptide YY3-36.
The New England journal of medicine 2003;349(10):941-8.
2000: Dominic J Withers; M White
Perspective: The insulin signaling system--a common link in the pathogenesis of type 2 diabetes.
Endocrinology 2000;141(6):1917-21.