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Owen Witte

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Jose S Gil; Dean O Campbell; Hidevaldo B Machado; Melissa McCracken; Caius Radu; Owen N Witte; Harvey R Herschman
Application of a Rapid, Simple, and Accurate Adenovirus-Based Method to Compare PET Reporter Gene/PET Reporter Probe Systems.
Francesca Giannoni; David Gjertson; Eric Gschweng; Cinnamon L Hardee; Michael L Kaufman; Ingrid Bahner; David Baltimore; Rebecca Chan; James S Economou; Vivian Gersuk; Antoni Ribas; Shantha Senadheera; Xiaoyan Wang; Jennifer Wherley; Owen N Witte; Donald B Kohn
Allelic Exclusion and Peripheral Reconstitution by TCR Transgenic T Cells Arising From Transduced Human Hematopoietic Stem/Progenitor Cells.
Chao Ma; Charles Ng; Antoni Ribas; Owen N Witte; Zhongqi Wu; Richard C Koya; Earl Avramis; David Baltimore; Ann F Cheung; Bartosz Chmielowski; Thinle Chodon; Alistair J Cochran; Begoña Comin-Anduix; James S Economou; James R Heath
Multifunctional T-cell analyses to study response and progression in adoptive cell transfer immunotherapy.

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All Publications

2013: Jose S Gil; Dean O Campbell; Hidevaldo B Machado; Melissa McCracken; Caius Radu; Owen N Witte; Harvey R Herschman
Application of a Rapid, Simple, and Accurate Adenovirus-Based Method to Compare PET Reporter Gene/PET Reporter Probe Systems.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2013;15(3):273-81.
2013: Francesca Giannoni; David Gjertson; Eric Gschweng; Cinnamon L Hardee; Michael L Kaufman; Ingrid Bahner; David Baltimore; Rebecca Chan; James S Economou; Vivian Gersuk; Antoni Ribas; Shantha Senadheera; Xiaoyan Wang; Jennifer Wherley; Owen N Witte; Donald B Kohn
Allelic Exclusion and Peripheral Reconstitution by TCR Transgenic T Cells Arising From Transduced Human Hematopoietic Stem/Progenitor Cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(5):1044-54.
2013: Chao Ma; Charles Ng; Antoni Ribas; Owen N Witte; Zhongqi Wu; Richard C Koya; Earl Avramis; David Baltimore; Ann F Cheung; Bartosz Chmielowski; Thinle Chodon; Alistair J Cochran; Begoña Comin-Anduix; James S Economou; James R Heath
Multifunctional T-cell analyses to study response and progression in adoptive cell transfer immunotherapy.
Cancer discovery 2013;3(4):418-29.
2013: Melissa N McCracken; Jami McLaughlin; Evan Nair-Gill; Christopher Nosala; Mireille Riedinger; Donghui Cheng; Aaron R Cooper; Eric H Gschweng; Donald B Kohn; Owen N Witte
Long-term in vivo monitoring of mouse and human hematopoietic stem cell engraftment with a human positron emission tomography reporter gene.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(5):1857-62.
2012: Yang Zong; Kiran K Chada; Jonathan I Epstein; Masashi Fukayama; Jiaoti Huang; Teppei Morikawa; Devipriya Sankarasharma; Owen N Witte
Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(50):E3395-404.
2012: Daniel Braas; Ethan Ahler; Matthias R Benz; Fritz C Eilber; David Nathanson; Mireille Riedinger; Kathleen B Smith; Brenna Tam; William D Tap; Owen N Witte; Hong Wu; Heather R Christofk
Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment.
Cancer discovery 2012;2(12):1109-17.
2012: Andrew S Goldstein; Owen N Witte
A plethora of progenitors in the post-natal prostate.
EMBO reports 2012;13(12):1036-7.
2012: Wayne R Austin; Dean O Campbell; Johannes Czernin; Harvey R Herschman; Terry Hsieh; David Nathanson; Michael E Phelps; Arun S Singh; Owen N Witte; Amanda L Armijo; Caius G Radu
Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.
The Journal of experimental medicine 2012;209(12):2215-28.
2012: Daniel Y Paik; Amanda M Schafenacker; May S Shung; Victor S Velasco; Owen N Witte; Donghui Cheng; Jiaoti Huang; Deanna M Janzen; Sanaz Memarzadeh
Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation.
Stem cells (Dayton, Ohio) 2012;30(11):2487-97.
2012: Tanya Stoyanova; Houjian Cai; Justin M Drake; Andrew S Goldstein; Jiaoti Huang; Owen N Witte
Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling.
Genes & development 2012;26(20):2271-85.
2012: Houjian Cai; Andrew S Kraft; Sanaz Memarzadeh; Tanya Stoyanova; Zanna Beharry; Owen N Witte
Collaboration of Kras and androgen receptor signaling stimulates EZH2 expression and tumor-propagating cells in prostate cancer.
Cancer research 2012;72(18):4672-81.
2012: Deanna M Janzen; Artur Jaroszewicz; Donghui Cheng; Andrew S Goldstein; Daniel Y Paik; Matteo Pellegrini; Amanda M Schafenacker; Owen N Witte; Sanaz Memarzadeh
Estrogen and progesterone together expand murine endometrial epithelial progenitor cells.
Stem cells (Dayton, Ohio) 2012;31(4):808-22.
2012: Satoshi Tsukada; R Cutler Allen; John W Belmont; Mary Ellen Conley; Max D Cooper; Ivana Klisak; Hiromi Kubagawa; Thuluvancheri Mohandas; Ornella Parolini; Shirley Quan; David J Rawlings; DC Saffran; Robert S Sparkes; Owen N Witte
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. 1993.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(7):2936-47.
2012: Justin M Drake; Andrew S Goldstein; Thomas G Graeber; Nicholas A Graham; Jiaoti Huang; Evangelia Komisopoulou; Amir Sedghi; Daniel A Smith; Tanya Stoyanova; Houjian Cai; Hong Zhang; Owen N Witte
Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(5):1643-8.
2012: Jing Jiao; Devon Lawson; Yunfeng Li; Linh M Tran; Shunyou Wang; Owen N Witte; Donghui Chen; Ladan Fazli; Isla P Garraway; Martin Gleave; Andrew S Goldstein; Changyong Guo; Antreas Hindoyan; Baohui Zhang; Hong Wu
Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells.
PloS one 2012;7(8):e42564.
2011: Sanaz Memarzadeh; Houjian Cai; Deanna M Janzen; Li Xin; Rita U Lukacs; Mireille Riedinger; Yang Zong; Karel DeGendt; Guido Verhoeven; Jiaoti Huang; Owen N Witte
Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(19):7962-7.
2011: Andrew S Goldstein; Justin M Drake; Daina L Burnes; David S Finley; Hong Zhang; Robert E Reiter; Jiaoti Huang; Owen N Witte
Purification and direct transformation of epithelial progenitor cells from primary human prostate.
Nature protocols 2011;6(5):656-67.
2011: Houjian Cai; Daniel A Smith; Sanaz Memarzadeh; Clifford A Lowell; Jonathan A Cooper; Owen N Witte
Differential transformation capacity of Src family kinases during the initiation of prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(16):6579-84.
2011: Johannes Schwarzenberg; Caius G Radu; Matthias Benz; Barbara Fueger; Andrew Q Tran; Michael E Phelps; Owen N Witte; Nagichettiar Satyamurthy; Johannes Czernin; Christiaan Schiepers
Human biodistribution and radiation dosimetry of novel PET probes targeting the deoxyribonucleoside salvage pathway.
European journal of nuclear medicine and molecular imaging 2011;38(4):711-21.
2011: Andrew S Goldstein; Yang Zong; Owen N Witte
A two-step toward personalized therapies for prostate cancer.
Science translational medicine 2011;3(72):72ps7.
2011: Xinqiang Huang; Eric Gschweng; Ben Van Handel; Donghui Cheng; Hanna K A Mikkola; Owen N Witte
Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells.
Blood 2011;117(7):2157-65.
2011: Ting-Hsiang Wu; Tara Teslaa; Sheraz Kalim; Christopher T French; Shahriar Moghadam; Randolph Wall; Jeffery F Miller; Owen N Witte; Michael A Teitell; Pei-Yu Chiou
Photothermal nanoblade for large cargo delivery into mammalian cells.
Analytical chemistry 2011;83(4):1321-7.
2011: Houjian Cai; Ivan Babic; Xiao Wei; Jiaoti Huang; Owen N Witte
Invasive prostate carcinoma driven by c-Src and androgen receptor synergy.
Cancer research 2011;71(3):862-72.
2011: M Thai; P Y Ting; Jami McLaughlin; D Cheng; Markus Müschen; Owen N Witte; J Colicelli
ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1.
Leukemia 2011;25(2):290-300.
2011: Aishe Chen; Lixue Dong; Nancy R Leffler; Owen N Witte; Adam S Asch; Li V Yang
Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway.
PloS one 2011;6(11):e27586.
2010: Rita U Lukacs; Sanaz Memarzadeh; Hong Wu; Owen N Witte
Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation.
Cell stem cell 2010;7(6):682-93.
2010: Robert A J Signer; Encarnacion Montecino-Rodriguez; Owen N Witte; Kenneth Dorshkind
Immature B-cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia.
Blood 2010;116(14):2522-30.
2010: Sanaz Memarzadeh; Yang Zong; Deanna M Janzen; Andrew S Goldstein; Donghui Cheng; Takeshi Kurita; Amanda M Schafenacker; Jiaoti Huang; Owen N Witte
Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(40):17298-303.
2010: Andrew S Goldstein; Tanya Stoyanova; Owen N Witte
Primitive origins of prostate cancer: in vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells.
Molecular oncology 2010;4(5):385-96.
2010: Richard C Koya; Stephen Mok; Begoña Comin-Anduix; Thinle Chodon; Caius G Radu; Michael I Nishimura; Owen N Witte; Antoni Ribas
Kinetic phases of distribution and tumor targeting by T cell receptor engineered lymphocytes inducing robust antitumor responses.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14286-91.
2010: Andrew S Goldstein; Jiaoti Huang; Changyong Guo; Isla P Garraway; Owen N Witte
Identification of a cell of origin for human prostate cancer.
Science (New York, N.Y.) 2010;329(5991):568-71.
2010: Chengyi J Shu; Dean O Campbell; Jason T Lee; Andrew Q Tran; Jordan C Wengrod; Owen N Witte; Michael E Phelps; Nagichettiar Satyamurthy; Johannes Czernin; Caius G Radu
Novel PET probes specific for deoxycytidine kinase.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010;51(7):1092-8.
2010: Evan Nair-Gill; Stephanie M Wiltzius; Xiao X Wei; Donghui Cheng; Mireille Riedinger; Caius G Radu; Owen N Witte
PET probes for distinct metabolic pathways have different cell specificities during immune responses in mice.
The Journal of clinical investigation 2010;120(6):2005-15.
2010: Ken-ichiro Kamei; Minori Ohashi; Eric Gschweng; Quinn Ho; Jane Suh; Jinghua Tang; Zeta Tak For Yu; Amander T Clark; April D Pyle; Michael A Teitell; Ki-Bum Lee; Owen N Witte; Hsian-Rong Tseng
Microfluidic image cytometry for quantitative single-cell profiling of human pluripotent stem cells in chemically defined conditions.
Lab on a chip 2010;10(9):1113-9.
2010: Rita U Lukacs; Andrew S Goldstein; Devon A Lawson; Donghui Cheng; Owen N Witte
Isolation, cultivation and characterization of adult murine prostate stem cells.
Nature protocols 2010;5(4):702-13.
2010: Sarah Brewer; Evan Nair-Gill; Bo Wei; Ling Chen; Xiaoxiao Li; Mireille Riedinger; Dean O Campbell; Stephanie Wiltzius; Nagichettiar Satyamurthy; Michael E Phelps; Caius Radu; Owen N Witte; Jonathan Braun
Epithelial uptake of [18F]1-(2'-deoxy-2'-arabinofuranosyl) cytosine indicates intestinal inflammation in mice.
Gastroenterology 2010;138(4):1266-75.
2010: David Baltimore; Owen N Witte; Lili Yang; James Economou; Antoni Ribas
Overcoming barriers to programming a therapeutic cellular immune response to fight melanoma.
Pigment cell & melanoma research 2010;23(2):288-9.
2010: Isla P Garraway; Wenyi Sun; Chau P Tran; Sven Perner; Bao Zhang; Andrew S Goldstein; Scott A Hahm; Maahum Haider; Christian S Head; Robert E Reiter; Mark A Rubin; Owen N Witte
Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo.
The Prostate 2010;70(5):491-501.
2010: Gerald Toy; Wayne R Austin; Hsiang-I Liao; Donghui Cheng; Arun Singh; Dean O Campbell; Tomo-O Ishikawa; Lynn W Lehmann; Nagichettiar Satyamurthy; Michael E Phelps; Harvey R Herschman; Johannes Czernin; Owen N Witte; Caius G Radu
Requirement for deoxycytidine kinase in T and B lymphocyte development.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(12):5551-6.
2010: Hanna K A Mikkola; Caius G Radu; Owen N Witte
Targeting leukemia stem cells.
Nature biotechnology 2010;28(3):237-8.
2010: Devon A Lawson; Yang Zong; Sanaz Memarzadeh; Li Xin; Jiaoti Huang; Owen N Witte
Basal epithelial stem cells are efficient targets for prostate cancer initiation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(6):2610-5.
2010: Rachel E Laing; Evan Nair-Gill; Owen N Witte; Caius G Radu
Visualizing cancer and immune cell function with metabolic positron emission tomography.
Current opinion in genetics & development 2010;20(1):100-5.
2010: Jiaoti Huang; Owen N Witte
A seminal finding for prostate cancer?
The New England journal of medicine 2010;362(2):175-6.
2009: Leah C Kottyan; Ann R Collier; Khanh H Cao; Kathryn A Niese; Megan Hedgebeth; Caius G Radu; Owen N Witte; Gurjit K Khurana Hershey; Marc E Rothenberg; Nives Zimmermann
Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner.
Blood 2009;114(13):2774-82.
2009: Yang Zong; Li Xin; Andrew S Goldstein; Devon A Lawson; Michael A Teitell; Owen N Witte
ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(30):12465-70.
2009: Gabriel A Kwong; Caius G Radu; Kiwook Hwang; Chengyi J Shu; Chao Ma; Richard C Koya; Begonya Comin-Anduix; Sine Reker Hadrup; Ryan C Bailey; Owen N Witte; Schumacher Ton; Antoni Ribas; James R Heath
Modular nucleic acid assembled p/MHC microarrays for multiplexed sorting of antigen-specific T cells.
Journal of the American Chemical Society 2009;131(28):9695-703.
2009: Zeta Tak For Yu; Ken-ichiro Kamei; Hiroko Takahashi; Chengyi Jenny Shu; Xiaopu Wang; George Wenfu He; Robert Silverman; Caius G Radu; Owen N Witte; KiBum Lee; Hsian-Rong Tseng
Integrated microfluidic devices for combinatorial cell-based assays.
Biomedical microdevices 2009;11(3):547-55.
2009: Rachel E Laing; Martin A Walter; Dean O Campbell; Harvey R Herschman; Nagichettiar Satyamurthy; Michael E Phelps; Johannes Czernin; Owen N Witte; Caius G Radu
Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2847-52.
2009: Ken-ichiro Kamei; Shuling Guo; Zeta Tak For Yu; Hiroko Takahashi; Eric Gschweng; Carol Suh; Xiaopu Wang; Jinghua Tang; Jami McLaughlin; Owen N Witte; KiBum Lee; Hsian-Rong Tseng
An integrated microfluidic culture device for quantitative analysis of human embryonic stem cells.
Lab on a chip 2009;9(4):555-63.
2009: Chengyi J Shu; Caius G Radu; Stephanie M Shelly; Dan D Vo; Robert M Prins; Antoni Ribas; Michael E Phelps; Owen N Witte
Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen.
International immunology 2009;21(2):155-65.
2008: Andrew S Goldstein; Devon A Lawson; Donghui Cheng; Wenyi Sun; Isla P Garraway; Owen N Witte
Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(52):20882-7.
2008: Robert A J Signer; Encarnacion Montecino-Rodriguez; Owen N Witte; Kenneth Dorshkind
Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf.
Genes & development 2008;22(22):3115-20.
2008: Bahram Valamehr; Steven J Jonas; Julien Polleux; Rong Qiao; Shuling Guo; Eric H Gschweng; Bangyan Stiles; Korey Kam; Tzy-Jiun M Luo; Owen N Witte; Xin Liu; Bruce Dunn; Hong Wu
Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14459-64.
2008: Robert M Prins; Chengyi J Shu; Caius G Radu; Dan D Vo; Haumith Khan-Farooqi; Horacio Soto; Meng-Yin Yang; Muh-Shi Lin; Stephanie Shelly; Owen N Witte; Antoni Ribas; Linda M Liau
Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain.
Cancer immunology, immunotherapy : CII 2008;57(9):1279-89.
2008: Caius G Radu; Chengyi J Shu; Evan Nair-Gill; Stephanie M Shelly; Jorge R Barrio; Nagichettiar Satyamurthy; Michael E Phelps; Owen N Witte
Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2'-deoxycytidine analog.
Nature medicine 2008;14(7):783-8.
2008: Roger S Lo; Owen N Witte
Transforming growth factor-beta activation promotes genetic context-dependent invasion of immortalized melanocytes.
Cancer research 2008;68(11):4248-57.
2008: Christoph Peter; Michaela Waibel; Caius G Radu; Li V Yang; Owen N Witte; Klaus Schulze-Osthoff; Sebastian Wesselborg; Kirsten Lauber
Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A.
The Journal of biological chemistry 2008;283(9):5296-305.
2008: Evan D Nair-Gill; Chengyi J Shu; Caius G Radu; Owen N Witte
Non-invasive imaging of adaptive immunity using positron emission tomography.
Immunological reviews 2008;221():214-28.
2008: Miranda L Moore; Michael A Teitell; Yoon Kim; Tetsuro Watabe; Robert E Reiter; Owen N Witte; Purnima Dubey
Deletion of PSCA increases metastasis of TRAMP-induced prostate tumors without altering primary tumor formation.
The Prostate 2008;68(2):139-51.
2008: Rita U Lukacs; Devon A Lawson; Li Xin; Y Zong; Isla P Garraway; A S Goldstein; Sanaz Memarzadeh; Owen N Witte
Epithelial stem cells of the prostate and their role in cancer progression.
Cold Spring Harbor symposia on quantitative biology 2008;73():491-502.
2007: Jami McLaughlin; Donghui Cheng; Oded Singer; Rita U Lukacs; Caius G Radu; Inder M Verma; Owen N Witte
Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(51):20501-6.
2007: Sanaz Memarzadeh; Li Xin; David J Mulholland; Alka Mansukhani; Hong Wu; Michael A Teitell; Owen N Witte
Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor.
Cancer cell 2007;12(6):572-85.
2007: Li Xin; Rita U Lukacs; Devon A Lawson; Donghui Cheng; Owen N Witte
Self-renewal and multilineage differentiation in vitro from murine prostate stem cells.
Stem cells (Dayton, Ohio) 2007;25(11):2760-9.
2007: Kenneth Dorshkind; Owen N Witte
Linking the hematopoietic microenvironment to imatinib-resistant Ph+ B-ALL.
Genes & development 2007;21(18):2249-52.
2007: Robert A J Signer; Encarnacion Montecino-Rodriguez; Owen N Witte; Jami McLaughlin; Kenneth Dorshkind
Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia.
Blood 2007;110(6):1831-9.
2007: Devon A Lawson; Owen N Witte
Stem cells in prostate cancer initiation and progression.
The Journal of clinical investigation 2007;117(8):2044-50.
2007: Ryan C Bailey; Gabriel A Kwong; Caius G Radu; Owen N Witte; James R Heath
DNA-encoded antibody libraries: a unified platform for multiplexed cell sorting and detection of genes and proteins.
Journal of the American Chemical Society 2007;129(7):1959-67.
2007: Caius G Radu; Chengyi J Shu; Stephanie M Shelly; Michael E Phelps; Owen N Witte
Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(6):1937-42.
2007: Li V Yang; Caius G Radu; Meenakshi Roy; Sunyoung Lee; Jami McLaughlin; Michael A Teitell; M Luisa Iruela-Arispe; Owen N Witte
Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor.
Molecular and cellular biology 2007;27(4):1334-47.
2007: Devon A Lawson; Li Xin; Rita U Lukacs; Donghui Cheng; Owen N Witte
Isolation and functional characterization of murine prostate stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(1):181-6.
2006: Li Xin; Michael A Teitell; Devon A Lawson; Andrew Kwon; Ingo K Mellinghoff; Owen N Witte
Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(20):7789-94.
2006: Qunying Lei; Jing Jiao; Li Xin; Chun-Ju Chang; Shunyou Wang; Jing Gao; Martin E Gleave; Owen N Witte; Xin Liu; Hong Wu
NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.
Cancer cell 2006;9(5):367-78.
2006: Abdul Q Khan; Goutam Sen; Shuling Guo; Owen N Witte; Clifford M Snapper
Induction of in vivo antipolysaccharide immunoglobulin responses to intact Streptococcus pneumoniae is more heavily dependent on Btk-mediated B-cell receptor signaling than antiprotein responses.
Infection and immunity 2006;74(2):1419-24.
2006: Shunyou Wang; Alejandro J Garcia; Michelle Wu; Devon A Lawson; Owen N Witte; Hong Wu
Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1480-5.
2006: Caius G Radu; Donghui Cheng; Amar Nijagal; Mireille Riedinger; Jami McLaughlin; Li V Yang; James Johnson; Owen N Witte
Normal immune development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the T-cell death-associated gene 8 receptor.
Molecular and cellular biology 2006;26(2):668-77.
2006: Shuling Guo; Matthew I Wahl; Owen N Witte
Mutational analysis of the SH2-kinase linker region of Bruton's tyrosine kinase defines alternative modes of regulation for cytoplasmic tyrosine kinase families.
International immunology 2006;18(1):79-87.
2005: Chung-Cheng Lee; Guodong Sui; Arkadij Elizarov; Chengyi Jenny Shu; Young-Shik Shin; Alek N Dooley; Jiang Huang; Antoine Daridon; Paul Wyatt; David B Stout; Hartmuth C Kolb; Owen N Witte; Nagichettiar Satyamurthy; James R Heath; Michael E Phelps; Stephen R Quake; Hsian-Rong Tseng
Multistep synthesis of a radiolabeled imaging probe using integrated microfluidics.
Science (New York, N.Y.) 2005;310(5755):1793-6.
2005: Chengyi J Shu; Shuling Guo; Young J Kim; Stephanie M Shelly; Amar Nijagal; Pritha Ray; Sanjiv S Gambhir; Caius G Radu; Owen N Witte
Visualization of a primary anti-tumor immune response by positron emission tomography.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(48):17412-7.
2005: Li Xin; Devon A Lawson; Owen N Witte
The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(19):6942-7.
2005: Li Wang; Caius G Radu; Li V Yang; Laurent A Bentolila; Mireille Riedinger; Owen N Witte
Lysophosphatidylcholine-induced surface redistribution regulates signaling of the murine G protein-coupled receptor G2A.
Molecular biology of the cell 2005;16(5):2234-47.
2005: Emmanuel Beillard; Owen N Witte
Unraveling kinase signaling pathways with chemical genetic and chemical proteomic approaches.
Cell cycle (Georgetown, Tex.) 2005;4(3):434-7.
2005: Caius G Radu; Amar Nijagal; Jami McLaughlin; Li Wang; Owen N Witte
Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1632-7.
2005: Li V Yang; Caius G Radu; Li Wang; Mireille Riedinger; Owen N Witte
Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A.
Blood 2005;105(3):1127-34.
2005: Owen N Witte; Janusz H S Kabarowski; Yan Xu; Lu Q Le; Kui Zhu
Retraction.
Science (New York, N.Y.) 2005;307(5707):206.
2005: Devon A Lawson; Li Xin; Rita U Lukacs; Q Xu; Donghui Cheng; Owen N Witte
Prostate stem cells and prostate cancer.
Cold Spring Harbor symposia on quantitative biology 2005;70():187-96.
2004: Stephane Wong; Jami McLaughlin; Donghui Cheng; C Zhang; Kevan M Shokat; Owen N Witte
Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(50):17456-61.
2004: Shuling Guo; Gregory Z Ferl; Rajendar Deora; Mireille Riedinger; Sheng Yin; James L Kerwin; Joseph A Loo; Owen N Witte
A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(39):14180-5.
2004: Young J Kim; Purnima Dubey; Pritha Ray; Sanjiv S Gambhir; Owen N Witte
Multimodality imaging of lymphocytic migration using lentiviral-based transduction of a tri-fusion reporter gene.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2004;6(5):331-40.
2004: Phyllis W Yu; Ruby S Tabuchi; Roberta M Kato; Alexander Astrakhan; Stephanie Humblet-Baron; Kevin Kipp; Keun Chae; Wilfried Ellmeier; Owen N Witte; David J Rawlings
Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer.
Blood 2004;104(5):1281-90.
2004: Michael G Kharas; Jonathan Deane; Stephane Wong; Karen R O'Bosky; Naomi Rosenberg; Owen N Witte; David A Fruman
Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells.
Blood 2004;103(11):4268-75.
2004: Caius G Radu; Li V Yang; Mireille Riedinger; Matthew Au; Owen N Witte
T cell chemotaxis to lysophosphatidylcholine through the G2A receptor.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):245-50.
2004: Stephane Wong; Owen N Witte
The BCR-ABL story: bench to bedside and back.
Annual review of immunology 2004;22():247-306.
2003: Stephane Wong; Jami McLaughlin; Donghui Cheng; Kevin Shannon; Lorraine Robb; Owen N Witte
IL-3 receptor signaling is dispensable for BCR-ABL-induced myeloproliferative disease.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(20):11630-5.
2003: Li Xin; Hisamitsu Ide; Yoon Kim; Purnima Dubey; Owen N Witte
In vivo regeneration of murine prostate from dissociated cell populations of postnatal epithelia and urogenital sinus mesenchyme.
Proceedings of the National Academy of Sciences of the United States of America 2003;100 Suppl 1():11896-903.
2003: Gregory Z Ferl; John M Timmerman; Owen N Witte
Extending the utility of gene profiling data by bridging microarray platforms.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10585-7.
2003: Lindsey R Whyburn; Kristina E Halcomb; Cristina M Contreras; Clifford A Lowell; Owen N Witte; Anne B Satterthwaite
Reduced dosage of Bruton's tyrosine kinase uncouples B cell hyperresponsiveness from autoimmunity in lyn-/- mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1850-8.
2003: Stephane Wong; Jami McLaughlin; Donghui Cheng; Owen N Witte
Cell context-specific effects of the BCR-ABL oncogene monitored in hematopoietic progenitors.
Blood 2003;101(10):4088-97.
2003: Lindsey R Whyburn; Kristina E Halcomb; Cristina M Contreras; Rajita Pappu; Owen N Witte; Andrew C Chan; Anne B Satterthwaite
Haploinsufficiency of B cell linker protein enhances B cell signaling defects in mice expressing a limiting dosage of Bruton's tyrosine kinase.
International immunology 2003;15(3):383-92.
2003: Purnima Dubey; Helen Su; Nona Adonai; Shouying Du; Antonio Rosato; Jonathan Braun; Sanjiv S Gambhir; Owen N Witte
Quantitative imaging of the T cell antitumor response by positron-emission tomography.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1232-7.
2002: Hisamitsu Ide; David Seligson; Sanaz Memarzadeh; Li Xin; Steve Horvath; Purnima Dubey; Maryann B Flick; Barry M Kacinski; Aarno Palotie; Owen N Witte
Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14404-9.
2002: Janusz H S Kabarowski; Yan Xu; Owen N Witte
Lysophosphatidylcholine as a ligand for immunoregulation.
Biochemical pharmacology 2002;64(2):161-7.
2002: Manabu Fujimoto; Jonathan C Poe; Anne B Satterthwaite; Matthew I Wahl; Owen N Witte; Thomas F Tedder
Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(11):5465-76.
2002: Lu Q Le; Janusz H S Kabarowski; Stephane Wong; Khoi Nguyen; Sanjiv S Gambhir; Owen N Witte
Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene.
Cancer cell 2002;1(4):381-91.
2002: Jinzi J Wu; Daniel E H Afar; Hoang Phan; Owen N Witte; Kit S Lam
Recognition of multiple substrate motifs by the c-ABL protein tyrosine kinase.
Combinatorial chemistry & high throughput screening 2002;5(1):83-91.
2002: David A Fruman; Gregory Z Ferl; Sam S An; Amber C Donahue; Anne B Satterthwaite; Owen N Witte
Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):359-64.
2002: Tetsuro Watabe; Mark Lin; Hisamitsu Ide; Annemarie A Donjacour; Gerald R Cunha; Owen N Witte; Robert E Reiter
Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoter.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):401-6.
2002: T Era; Stephane Wong; Owen N Witte
Analysis of Bcr-Abl function using an in vitro embryonic stem cell differentiation system.
Methods in molecular biology (Clifton, N.J.) 2002;185():83-95.
2001: Keng Zhu; Linnea M Baudhuin; Guiying Hong; F S Williams; Kelly L Cristina; Janusz H S Kabarowski; Owen N Witte; Yan Xu
Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4.
The Journal of biological chemistry 2001;276(44):41325-35.
2001: S W Kang; Matthew I Wahl; J Chu; Jiro Kitaura; Y Kawakami; Roberta M Kato; R Tabuchi; A Tarakhovsky; T Kawakami; C W Turck; Owen N Witte; David J Rawlings
PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.
The EMBO journal 2001;20(20):5692-702.
2001: Stephane Wong; Owen N Witte
Modeling Philadelphia chromosome positive leukemias.
Oncogene 2001;20(40):5644-59.
2001: Janusz H S Kabarowski; Keng Zhu; Lu Q Le; Owen N Witte; Yan Xu
Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.
Science (New York, N.Y.) 2001;293(5530):702-5.
2001: Lu Q Le; Janusz H S Kabarowski; Z Weng; Anne B Satterthwaite; Eric T Harvill; ER Jensen; JF Miller; Owen N Witte
Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome.
Immunity 2001;14(5):561-71.
2001: Purnima Dubey; H Wu; Robert E Reiter; Owen N Witte
Alternative pathways to prostate carcinoma activate prostate stem cell antigen expression.
Cancer research 2001;61(8):3256-61.
2001: Taku Kouro; K Nagata; Satoshi Takaki; Sazuku Nisitani; Masayuki Hirano; Matthew I Wahl; Owen N Witte; Hajime Karasuyama; Kiyoshi Takatsu
Bruton's tyrosine kinase is required for signaling the CD79b-mediated pro-B to pre-B cell transition.
International immunology 2001;13(4):485-93.
2001: DC Saffran; Arthur B Raitano; RS Hubert; Owen N Witte; Robert E Reiter; Aya Jakobovits
Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2658-63.
2001: MG Tomlinson; D B Woods; M McMahon; Matthew I Wahl; Owen N Witte; T Kurosaki; JB Bolen; J A Johnston
A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells.
BMC immunology 2001;2():4.
2000: Janusz H S Kabarowski; J D Feramisco; Lu Q Le; J L Gu; Shiuh-Wen Luoh; Melvin I Simon; Owen N Witte
Direct genetic demonstration of G alpha 13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12109-14.
2000: Y M Lim; Stephane Wong; G Lau; Owen N Witte; John Colicelli
BCR/ABL inhibition by an escort/phosphatase fusion protein.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12233-8.
2000: Y Kawakami; Jiro Kitaura; Anne B Satterthwaite; R M Kato; K Asai; SE Hartman; Mari Maeda-Yamamoto; Clifford A Lowell; David J Rawlings; Owen N Witte; Toshiaki Kawakami
Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(3):1210-9.
2000: David A Fruman; Anne B Satterthwaite; Owen N Witte
Xid-like phenotypes: a B cell signalosome takes shape.
Immunity 2000;13(1):1-3.
2000: Anne B Satterthwaite; F Willis; P Kanchanastit; David A Fruman; L C Cantley; C D Helgason; R K Humphries; Clifford A Lowell; M Simon; Michael Leitges; A Tarakhovsky; Thomas F Tedder; Ralf Lesche; Hong Wu; Owen N Witte
A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6687-92.
2000: Anne B Satterthwaite; Owen N Witte
The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective.
Immunological reviews 2000;175():120-7.
2000: Sazuku Nisitani; Anne B Satterthwaite; Koichi Akashi; I L Weissman; Owen N Witte; Matthew I Wahl
Posttranscriptional regulation of Bruton's tyrosine kinase expression in antigen receptor-stimulated splenic B cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2737-42.
2000: Z Gu; G Thomas; Joyce Yamashiro; I Peter Shintaku; Frederick Dorey; Arthur B Raitano; Owen N Witte; Jonathan W Said; Massimo Loda; Robert E Reiter
Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer.
Oncogene 2000;19(10):1288-96.
2000: A Oda; Yasuo Ikeda; HD Ochs; Brian J Druker; K Ozaki; Makoto Handa; T Ariga; Y Sakiyama; Owen N Witte; Matthew I Wahl
Rapid tyrosine phosphorylation and activation of Bruton's tyrosine/Tec kinases in platelets induced by collagen binding or CD32 cross-linking.
Blood 2000;95(5):1663-70.
2000: T Era; Owen N Witte
Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fate.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(4):1737-42.
2000: Janusz H S Kabarowski; Owen N Witte
Consequences of BCR-ABL expression within the hematopoietic stem cell in chronic myeloid leukemia.
Stem cells (Dayton, Ohio) 2000;18(6):399-408.
1999: N Craft; C Chhor; Chris Tran; Arie Belldegrun; Jean B deKernion; Owen N Witte; Jonathan Said; Robert E Reiter; Charles L Sawyers
Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process.
Cancer research 1999;59(19):5030-6.
1999: Sazuku Nisitani; Roberta M Kato; David J Rawlings; Owen N Witte; Matthew I Wahl
In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):2221-6.
1999: DC Saffran; Robert E Reiter; Aya Jakobovits; Owen N Witte
Target antigens for prostate cancer immunotherapy.
Cancer metastasis reviews 1999;18(4):437-49.
1998: AC Fluckiger; Eva Sanz; Maria I Garcia-Lloret; T Su; Q l Hao; Roberta M Kato; S Quan; Antonio de la Hera; Gay M Crooks; Owen N Witte; David J Rawlings
In vitro reconstitution of human B-cell ontogeny: from CD34(+) multipotent progenitors to Ig-secreting cells.
Blood 1998;92(12):4509-20.
1998: S Mahlmann; Jami McLaughlin; Daniel E H Afar; R Mohr; R J Kay; Owen N Witte
Dissection of signaling pathways and cloning of new signal transducers in tyrosine kinase-induced pathways by genetic selection.
Leukemia 1998;12(12):1858-65.
1998: Anne B Satterthwaite; David J Rawlings; Owen N Witte
DSHP: a "power bar" for sustained immune responses?
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13355-7.
1998: Z Weng; AC Fluckiger; Sazuku Nisitani; Matthew I Wahl; Lu Q Le; C A Hunter; A A Fernal; M M Le Beau; Owen N Witte
A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12334-9.
1998: Renata Stripecke; Dianne Skelton; Tanja A Gruber; Daniel E H Afar; PK Pattengale; Owen N Witte; Donald B Kohn
Immune response to Philadelphia chromosome-positive acute lymphoblastic leukemia induced by expression of CD80, interleukin 2, and granulocyte-macrophage colony-stimulating factor.
Human gene therapy 1998;9(14):2049-62.
1998: Anne B Satterthwaite; Clifford A Lowell; Wasif Khan; P Sideras; FW Alt; Owen N Witte
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.
The Journal of experimental medicine 1998;188(5):833-44.
1998: Anne B Satterthwaite; Z Li; Owen N Witte
Btk function in B cell development and response.
Seminars in immunology 1998;10(4):309-16.
1998: D Hata; Y Kawakami; N Inagaki; C S Lantz; T Kitamura; Wasif Khan; Mari Maeda-Yamamoto; T Miura; W Han; SE Hartman; L Yao; H Nagai; A E Goldfeld; FW Alt; Stephen J Galli; Owen N Witte; Toshiaki Kawakami
Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production.
The Journal of experimental medicine 1998;187(8):1235-47.
1998: AC Fluckiger; Z Li; Roberta M Kato; Matthew I Wahl; HD Ochs; R Longnecker; Jean-Pierre Kinet; Owen N Witte; Andrew M Scharenberg; David J Rawlings
Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation.
The EMBO journal 1998;17(7):1973-85.
1998: Hiroaki Honda; H Oda; Takahiro Suzuki; Tokiharu Takahashi; Owen N Witte; Keiya Ozawa; T Ishikawa; Yoshio Yazaki; Hisamura Hirai
Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210bcr/abl: a novel transgenic model for human Ph1-positive leukemias.
Blood 1998;91(6):2067-75.
1998: Gustavo Amarante-Mendes; AJ McGahon; W K Nishioka; Daniel E H Afar; Owen N Witte; Douglas R Green
Bcl-2-independent Bcr-Abl-mediated resistance to apoptosis: protection is correlated with up regulation of Bcl-xL.
Oncogene 1998;16(11):1383-90.
1998: Robert E Reiter; Z Gu; Tetsuro Watabe; G Thomas; K Szigeti; E Davis; M Wahl; Sazuku Nisitani; Joyce Yamashiro; M M Le Beau; Massimo Loda; Owen N Witte
Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1735-40.
1997: Z Li; Matthew I Wahl; Alicia Eguinoa; Len R Stephens; Phillip T Hawkins; Owen N Witte
Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13820-5.
1997: Anne B Satterthwaite; Hilde Cheroutre; Wasif Khan; P Sideras; Owen N Witte
Btk dosage determines sensitivity to B cell antigen receptor cross-linking.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13152-7.
1997: Matthew I Wahl; AC Fluckiger; Roberta M Kato; H Park; Owen N Witte; David J Rawlings
Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11526-33.
1997: T Li; David J Rawlings; H Park; Roberta M Kato; Owen N Witte; Anne B Satterthwaite
Constitutive membrane association potentiates activation of Bruton tyrosine kinase.
Oncogene 1997;15(12):1375-83.
1997: Daniel E H Afar; L Han; Jami McLaughlin; Stephane Wong; Ajay Dhaka; K Parmar; N Rosenberg; Owen N Witte; John Colicelli
Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1.
Immunity 1997;6(6):773-82.
1996: Anne B Satterthwaite; Owen N Witte
Lessons from human genetic variants in the study of B-cell differentiation.
Current opinion in immunology 1996;8(4):454-8.
1996: Todd R Golub; A Goga; G F Barker; Daniel E H Afar; Jami McLaughlin; S K Bohlander; J D Rowley; Owen N Witte; D Gary Gilliland
Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia.
Molecular and cellular biology 1996;16(8):4107-16.
1996: Daniel E H Afar; H Park; B W Howell; David J Rawlings; J Cooper; Owen N Witte
Regulation of Btk by Src family tyrosine kinases.
Molecular and cellular biology 1996;16(7):3465-71.
1996: H Park; Matthew I Wahl; Daniel E H Afar; C W Turck; David J Rawlings; C Tam; Andrew M Scharenberg; Jean-Pierre Kinet; Owen N Witte
Regulation of Btk function by a major autophosphorylation site within the SH3 domain.
Immunity 1996;4(5):515-25.
1996: David J Rawlings; Andrew M Scharenberg; H Park; Matthew I Wahl; S Lin; Roberta M Kato; AC Fluckiger; Owen N Witte; Jean-Pierre Kinet
Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.
Science (New York, N.Y.) 1996;271(5250):822-5.
1995: Daniel E H Afar; Jami McLaughlin; C J Sherr; Owen N Witte; M F Roussel
Signaling by ABL oncogenes through cyclin D1.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9540-4.
1995: A Goga; Jami McLaughlin; Daniel E H Afar; DC Saffran; Owen N Witte
Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene.
Cell 1995;82(6):981-8.
1995: J D Kerner; M W Appleby; R N Mohr; S Chien; David J Rawlings; C R Maliszewski; Owen N Witte; Roger M Perlmutter
Impaired expansion of mouse B cell progenitors lacking Btk.
Immunity 1995;3(3):301-12.
1995: A Goga; Xueli Liu; T M Hambuch; K Senechal; E Major; A J Berk; Owen N Witte; Charles L Sawyers
p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase.
Oncogene 1995;11(4):791-9.
1995: David J Rawlings; Owen N Witte
The Btk subfamily of cytoplasmic tyrosine kinases: structure, regulation and function.
Seminars in immunology 1995;7(4):237-46.
1995: T Li; S Tsukada; Anne B Satterthwaite; M H Havlik; H Park; K Takatsu; Owen N Witte
Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain.
Immunity 1995;2(5):451-60.
1995: David J Rawlings; S G Quan; Roberta M Kato; Owen N Witte
Long-term culture system for selective growth of human B-cell progenitors.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1570-4.
1995: E A Faust; David J Rawlings; DC Saffran; Owen N Witte
Development of btk transgenic mice.
Current topics in microbiology and immunology 1995;194():363-70.
1995: Daniel E H Afar; Owen N Witte
Characterization of breakpoint cluster region kinase and SH2-binding activities.
Methods in enzymology 1995;256():125-9.
1994: S L Orr; T P Hughes; C L Sawyers; Roberta M Kato; S G Quan; S P Williams; Owen N Witte; Leroy Hood
Isolation of unknown genes from human bone marrow by differential screening and single-pass cDNA sequence determination.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):11869-73.
1994: S Tsukada; M I Simon; Owen N Witte; A Katz
Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):11256-60.
1994: S Tsukada; David J Rawlings; Owen N Witte
Role of Bruton's tyrosine kinase in immunodeficiency.
Current opinion in immunology 1994;6(4):623-30.
1994: Q Zhu; M Zhang; David J Rawlings; Mauno Vihinen; TL Hagemann; DC Saffran; SP Kwan; L Nilsson; C I Smith; Owen N Witte; Shi-Han Chen; Hans D Ochs
Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA).
The Journal of experimental medicine 1994;180(2):461-70.
1994: DC Saffran; Ornella Parolini; M E Fitch-Hilgenberg; David J Rawlings; Daniel E H Afar; Owen N Witte; Mary Ellen Conley
Brief report: a point mutation in the SH2 domain of Bruton's tyrosine kinase in atypical X-linked agammaglobulinemia.
The New England journal of medicine 1994;330(21):1488-91.
1994: Daniel E H Afar; A Goga; Jami McLaughlin; Owen N Witte; Charles L Sawyers
Differential complementation of Bcr-Abl point mutants with c-Myc.
Science (New York, N.Y.) 1994;264(5157):424-6.
1994: David J Rawlings; Owen N Witte
Bruton's tyrosine kinase is a key regulator in B-cell development.
Immunological reviews 1994;138():105-19.
1994: S Tsukada; Owen N Witte
X-linked agammaglobulinemia and Bruton's tyrosine kinase.
Advances in experimental medicine and biology 1994;365():233-8.
1994: Daniel E H Afar; A Goga; L Cohen; Charles L Sawyers; Jami McLaughlin; R N Mohr; Owen N Witte
Genetic approaches to defining signaling by the CML-associated tyrosine kinase BCR-ABL.
Cold Spring Harbor symposia on quantitative biology 1994;59():589-94.
1993: A Goga; Jami McLaughlin; Ann Marie Pendergast; K Parmar; A Muller; N Rosenberg; Owen N Witte
Oncogenic activation of c-ABL by mutation within its last exon.
Molecular and cellular biology 1993;13(8):4967-75.
1993: M L Gishizky; J Johnson-White; Owen N Witte
Evaluating the effect of P210 BCR/ABL on growth of hematopoietic progenitor cells and its role in the pathogenesis of human chronic myelogenous leukemia.
Seminars in hematology 1993;30(3 Suppl 3):6-8.
1993: M L Gishizky; J Johnson-White; Owen N Witte
Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3755-9.
1993: A J Muller; Ann Marie Pendergast; K Parmar; M H Havlik; N Rosenberg; Owen N Witte
En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3457-61.
1993: E A Faust; DC Saffran; D Toksoz; D A Williams; Owen N Witte
Distinctive growth requirements and gene expression patterns distinguish progenitor B cells from pre-B cells.
The Journal of experimental medicine 1993;177(4):915-23.
1993: Ann Marie Pendergast; M L Gishizky; M H Havlik; Owen N Witte
SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence.
Molecular and cellular biology 1993;13(3):1728-36.
1993: Owen N Witte
Role of the BCR-ABL oncogene in human leukemia: fifteenth Richard and Hinda Rosenthal Foundation Award Lecture.
Cancer research 1993;53(3):485-9.
1992: A J Muller; Ann Marie Pendergast; M H Havlik; L Puil; T Pawson; Owen N Witte
A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction.
Molecular and cellular biology 1992;12(11):5087-93.
1992: Charles L Sawyers; W Callahan; Owen N Witte
Dominant negative MYC blocks transformation by ABL oncogenes.
Cell 1992;70(6):901-10.
1992: M L Gishizky; Owen N Witte
Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro.
Science (New York, N.Y.) 1992;256(5058):836-9.
1992: Charles L Sawyers; M L Gishizky; S Quan; David W Golde; Owen N Witte
Propagation of human blastic myeloid leukemias in the SCID mouse.
Blood 1992;79(8):2089-98.
1992: M L Gishizky; Owen N Witte
BCR/ABL enhances growth of multipotent progenitor cells but does not block their differentiation potential in vitro.
Current topics in microbiology and immunology 1992;182():65-72.
1992: DC Saffran; E A Faust; Owen N Witte
Establishment of a reproducible culture technique for the selective growth of B-cell progenitors.
Current topics in microbiology and immunology 1992;182():37-43.
1991: Y Maru; Owen N Witte
The BCR gene encodes a novel serine/threonine kinase activity within a single exon.
Cell 1991;67(3):459-68.
1991: M L Gishizky; Jami McLaughlin; Ann Marie Pendergast; Owen N Witte
The 5' non-coding region of the BCR/ABL oncogene augments its ability to stimulate the growth of immature lymphoid cells.
Oncogene 1991;6(8):1299-306.
1991: Ann Marie Pendergast; A J Muller; M H Havlik; Y Maru; Owen N Witte
BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner.
Cell 1991;66(1):161-71.
1991: Ann Marie Pendergast; A J Muller; M H Havlik; R Clark; F McCormick; Owen N Witte
Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(13):5927-31.
1991: A J Muller; J C Young; Ann Marie Pendergast; M Pondel; N R Landau; Dan R Littman; Owen N Witte
BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.
Molecular and cellular biology 1991;11(4):1785-92.
1991: N P Shah; Owen N Witte; Christopher T Denny
Characterization of the BCR promoter in Philadelphia chromosome-positive and -negative cell lines.
Molecular and cellular biology 1991;11(4):1854-60.
1991: J C Young; M L Gishizky; Owen N Witte
Hyperexpression of interleukin-7 is not necessary or sufficient for transformation of a pre-B lymphoid cell line.
Molecular and cellular biology 1991;11(2):854-63.
1991: Charles L Sawyers; C T Denny; Owen N Witte
Leukemia and the disruption of normal hematopoiesis.
Cell 1991;64(2):337-50.
1990: Owen N Witte
Steel locus defines new multipotent growth factor.
Cell 1990;63(1):5-6.
1990: T G Lugo; Ann Marie Pendergast; A J Muller; Owen N Witte
Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.
Science (New York, N.Y.) 1990;247(4946):1079-82.
1990: P A Scherle; Kenneth Dorshkind; Owen N Witte
Clonal lymphoid progenitor cell lines expressing the BCR/ABL oncogene retain full differentiative function.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(5):1908-12.
1990: Charles L Sawyers; L Timson; E S Kawasaki; Steven S Clark; Owen N Witte; Richard Champlin
Molecular relapse in chronic myelogenous leukemia patients after bone marrow transplantation detected by polymerase chain reaction.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(2):563-7.
1990: P A Scherle; Owen N Witte
Functionality of clonal lymphoid progenitor cells expressing the P210 BCR/ABL oncogene.
Current topics in microbiology and immunology 1990;166():189-95.
1990: K A Denis; S Provost; Owen N Witte; R L Brinster; Ursula Storb
Delay of early B-lymphocyte development by gamma 2b immunoglobulin transgene: effect on differentiation-specific molecules.
Developmental immunology 1990;1(2):105-12.
1989: Vesna Najfeld; J Cuttner; A Figur; E S Kawasaki; Owen N Witte; Steven S Clark
P185BCR-ABL in two patients with late appearing Philadelphia chromosome-positive acute nonlymphocytic leukemia.
Leukemia 1989;3(12):841-6.
1989: A J Muller; Owen N Witte
The 5' noncoding region of the human leukemia-associated oncogene BCR/ABL is a potent inhibitor of in vitro translation.
Molecular and cellular biology 1989;9(11):5234-8.
1989: Christopher T Denny; N P Shah; S Ogden; Cheryl L Willman; T McConnell; William M Crist; A Carroll; Owen N Witte
Localization of preferential sites of rearrangement within the BCR gene in Philadelphia chromosome-positive acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4254-8.
1989: Ann Marie Pendergast; R Clark; E S Kawasaki; F P McCormick; Owen N Witte
Baculovirus expression of functional P210 BCR-ABL oncogene product.
Oncogene 1989;4(6):759-66.
1989: Jami McLaughlin; E Chianese; Owen N Witte
Alternative forms of the BCR-ABL oncogene have quantitatively different potencies for stimulation of immature lymphoid cells.
Molecular and cellular biology 1989;9(5):1866-74.
1989: M S Timmons; Owen N Witte
Structural characterization of the BCR gene product.
Oncogene 1989;4(5):559-67.
1989: K A Denis; L K Timson; Owen N Witte
VH repertoire in progeny of long term lymphoid-cultured cells used to reconstitute immunodeficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(9):2981-7.
1989: L W Dow; N Tachibana; Susana C Raimondi; S J Lauer; Owen N Witte; Steven S Clark
Comparative biochemical and cytogenetic studies of childhood acute lymphoblastic leukemia with the Philadelphia chromosome and other 22q 11 variants.
Blood 1989;73(5):1291-7.
1989: T G Lugo; Owen N Witte
The BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc.
Molecular and cellular biology 1989;9(3):1263-70.
1989: Steven S Clark; W M Crist; Owen N Witte
Molecular pathogenesis of Ph-positive leukemias.
Annual review of medicine 1989;40():113-22.
1988: J C Young; Owen N Witte
Selective transformation of primitive lymphoid cells by the BCR/ABL oncogene expressed in long-term lymphoid or myeloid cultures.
Molecular and cellular biology 1988;8(10):4079-87.
1988: E S Kawasaki; Steven S Clark; M Y Coyne; S D Smith; Richard Champlin; Owen N Witte; F P McCormick
Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(15):5698-702.
1988: Steven S Clark; Jami McLaughlin; M Timmons; Ann Marie Pendergast; Y Ben-Neriah; L W Dow; W Crist; G Rovera; S D Smith; Owen N Witte
Expression of a distinctive BCR-ABL oncogene in Ph1-positive acute lymphocytic leukemia (ALL).
Science (New York, N.Y.) 1988;239(4841 Pt 1):775-7.
1987: Ann Marie Pendergast; J A Traugh; Owen N Witte
Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation.
Molecular and cellular biology 1987;7(12):4280-9.
1987: K A Denis; Owen N Witte
Long-term culture systems for analysis of early B lymphocyte development.
International reviews of immunology 1987;2(3):285-305.
1987: A M Mes-Masson; Owen N Witte
Role of the abl oncogene in chronic myelogenous leukemia.
Advances in cancer research 1987;49():53-74.
1986: Owen N Witte
Involvement of the abl oncogene in human chronic myelogenous leukemia.
Princess Takamatsu symposia 1986;17():143-9.
1985: Ursula Storb; K A Denis; R L Brinster; Owen N Witte
Pre-B cells in kappa-transgenic mice.
Nature 1985;316(6026):356-8.
1984: S F Ziegler; L J Treiman; Owen N Witte
kappa gene diversity among the clonal progeny of pre-B lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(5):1529-33.
1983: C A Whitlock; S F Ziegler; Owen N Witte
Progression of the transformed phenotype in clonal lines of Abelson virus-infected lymphocytes.
Molecular and cellular biology 1983;3(4):596-604.
1983: C A Whitlock; S F Ziegler; L J Treiman; J I Stafford; Owen N Witte
Differentiation of cloned populations of immature B cells after transformation with Abelson murine leukemia virus.
Cell 1983;32(3):903-11.
1981: S F Ziegler; C A Whitlock; S P Goff; A Gifford; Owen N Witte
Lethal effect of the Abelson murine leukemia virus transforming gene product.
Cell 1981;27(3 Pt 2):477-86.