Alfred Wittinghofer

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Meyer Simon; Böhme Sabine; Krüger André; Steinhoff Heinz-Jürgen; Klare Johann P; Wittinghofer Alfred
Kissing G domains of MnmE monitored by X-ray crystallography and pulse electron paramagnetic resonance spectroscopy.
Veltel Stefan; Wittinghofer Alfred
RPGR and RP2: targets for the treatment of X-linked retinitis pigmentosa?
Meyer Simon; Wittinghofer Alfred; Versées Wim
G-domain dimerization orchestrates the tRNA wobble modification reaction in the MnmE/GidA complex.

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All Publications

2009: Meyer Simon; Böhme Sabine; Krüger André; Steinhoff Heinz-Jürgen; Klare Johann P; Wittinghofer Alfred
Kissing G domains of MnmE monitored by X-ray crystallography and pulse electron paramagnetic resonance spectroscopy.
PLoS biology 2009;7(10):e1000212.
2009: Veltel Stefan; Wittinghofer Alfred
RPGR and RP2: targets for the treatment of X-linked retinitis pigmentosa?
Expert opinion on therapeutic targets 2009;13(10):1239-51.
2009: Meyer Simon; Wittinghofer Alfred; Versées Wim
G-domain dimerization orchestrates the tRNA wobble modification reaction in the MnmE/GidA complex.
Journal of molecular biology 2009;392(4):910-22.
2009: Sirajuddin Minhajuddin; Farkasovsky Marian; Zent Eldar; Wittinghofer Alfred
GTP-induced conformational changes in septins and implications for function.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(39):16592-7.
2009: Yaman Elif; Gasper Raphael; Koerner Carolin; Wittinghofer Alfred; Tazebay Uygar H
RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange.
The FEBS journal 2009;276(16):4607-16.
2009: Gasper Raphael; Meyer Simon; Gotthardt Katja; Sirajuddin Minhajuddin; Wittinghofer Alfred
It takes two to tango: regulation of G proteins by dimerization.
Nature reviews. Molecular cell biology 2009;10(6):423-9.
2009: Ottmann Christian; Weyand Michael; Sassa Takeshi; Inoue Takatsugu; Kato Nobuo; Wittinghofer Alfred; Oecking Claudia
A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A.
Journal of molecular biology 2009;386(4):913-9.
2009: Uhlenbrock Katharina; Weiwad Matthias; Wetzker Reinhard; Fischer Gunter; Wittinghofer Alfred; Rubio Ignacio
Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway.
FEBS letters 2009;583(6):965-70.
2008: Lammers Michael; Meyer Simon; Kühlmann Dorothee; Wittinghofer Alfred
Specificity of interactions between mDia isoforms and Rho proteins.
The Journal of biological chemistry 2008;283(50):35236-46.
2008: Gotthardt Katja; Weyand Michael; Kortholt Arjan; Van Haastert Peter J M; Wittinghofer Alfred
Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase.
The EMBO journal 2008;27(17):2352.
2008: Gremer Lothar; Gilsbach Bernd; Ahmadian Mohammad Reza; Wittinghofer Alfred
Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGap interaction.
Biological chemistry 2008;389(9):1163-71.
2008: Rehmann H; Brüning M; Berghaus C; Schwarten M; Köhler K; Stocker H; Stoll R; Zwartkruis F J; Wittinghofer A
Biochemical characterisation of TCTP questions its function as a guanine nucleotide exchange factor for Rheb.
FEBS letters 2008;582(20):3005-10.
2008: Gotthardt Katja; Weyand Michael; Kortholt Arjan; Van Haastert Peter J M; Wittinghofer Alfred
Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase.
The EMBO journal 2008;27(16):2239-49.
2008: Schrader Nils; Koerner Carolin; Koessmeier Katja; Bangert Jan-Amadé; Wittinghofer Alfred; Stoll Raphael; Vetter Ingrid R
The crystal structure of the Ran-Nup153ZnF2 complex: a general Ran docking site at the nuclear pore complex.
Structure (London, England : 1993) 2008;16(7):1116-25.
2008: Veltel Stefan; Kravchenko Aleksandra; Ismail Shehab; Wittinghofer Alfred
Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex.
FEBS letters 2008;582(17):2501-7.
2008: Meyer S; Scrima A; Versées W; Wittinghofer A
Crystal structures of the conserved tRNA-modifying enzyme GidA: implications for its interaction with MnmE and substrate.
Journal of molecular biology 2008;380(3):532-47.
2008: Gasper Raphael; Thomas Christoph; Ahmadian Mohammad Reza; Wittinghofer Alfred
The role of the conserved switch II glutamate in guanine nucleotide exchange factor-mediated nucleotide exchange of GTP-binding proteins.
Journal of molecular biology 2008;379(1):51-63.
2008: Kötting Carsten; Kallenbach Angela; Suveyzdis Yan; Wittinghofer Alfred; Gerwert Klaus
The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(17):6260-5.
2008: Veltel Stefan; Gasper Raphael; Eisenacher Elke; Wittinghofer Alfred
The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3.
Nature structural & molecular biology 2008;15(4):373-80.
2008: Scrima Andrea; Thomas Christoph; Deaconescu Delia; Wittinghofer Alfred
The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues.
The EMBO journal 2008;27(7):1145-53.
2008: Berken Antje; Wittinghofer Alfred
Structure and function of Rho-type molecular switches in plants.
Plant physiology and biochemistry : PPB / Société française de physiologie végétale 2008;46(3):380-93.
2007: Sirajuddin Minhajuddin; Farkasovsky Marian; Hauer Florian; Kühlmann Dorothee; Macara Ian G; Weyand Michael; Stark Holger; Wittinghofer Alfred
Structural insight into filament formation by mammalian septins.
Nature 2007;449(7160):311-5.
2007: Koller-Eichhorn Roland; Marquardt Tobias; Gail Robert; Wittinghofer Alfred; Kostrewa Dirk; Kutay Ulrike; Kambach Christian
Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins.
The Journal of biological chemistry 2007;282(27):19928-37.
2007: Bos Johannes L; Rehmann Holger; Wittinghofer Alfred
GEFs and GAPs: critical elements in the control of small G proteins.
Cell 2007;129(5):865-77.
2007: Chakrabarti Partha P; Daumke Oliver; Suveyzdis Yan; Kötting Carsten; Gerwert Klaus; Wittinghofer Alfred
Insight into catalysis of a unique GTPase reaction by a combined biochemical and FTIR approach.
Journal of molecular biology 2007;367(4):983-95.
2007: Ottmann Christian; Marco Sergio; Jaspert Nina; Marcon Caroline; Schauer Nicolas; Weyand Michael; Vandermeeren Caroline; Duby Geoffrey; Boutry Marc; Wittinghofer Alfred; Rigaud Jean-Louis; Oecking Claudia
Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy.
Molecular cell 2007;25(3):427-40.
2007: Ottmann Christian; Yasmin Lubna; Weyand Michael; Veesenmeyer Jeffrey L; Diaz Maureen H; Palmer Ruth H; Francis Matthew S; Hauser Alan R; Wittinghofer Alfred; Hallberg Bengt
Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis.
The EMBO journal 2007;26(3):902-13.
2007: Thomas Christoph; Fricke Inka; Scrima Andrea; Berken Antje; Wittinghofer Alfred
Structural evidence for a common intermediate in small G protein-GEF reactions.
Molecular cell 2007;25(1):141-9.
2007: Rehmann Holger; Wittinghofer Alfred; Bos Johannes L
Capturing cyclic nucleotides in action: snapshots from crystallographic studies.
Nature reviews. Molecular cell biology 2007;8(1):63-73.
2006: Brunsveld Luc; Kuhlmann Jürgen; Alexandrov Kirill; Wittinghofer Alfred; Goody Roger S; Waldmann Herbert
Lipidated ras and rab peptides and proteins--synthesis, structure, and function.
Angewandte Chemie (International ed. in English) 2006;45(40):6622-46.
2006: Kötting Carsten; Blessenohl Marco; Suveyzdis Yan; Goody Roger S; Wittinghofer Alfred; Gerwert Klaus
A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(38):13911-6.
2006: Gasper Raphael; Scrima Andrea; Wittinghofer Alfred
Structural insights into HypB, a GTP-binding protein that regulates metal binding.
The Journal of biological chemistry 2006;281(37):27492-502.
2006: Kortholt Arjan; Rehmann Holger; Kae Helmut; Bosgraaf Leonard; Keizer-Gunnink Ineke; Weeks Gerald; Wittinghofer Alfred; Van Haastert Peter J M
Characterization of the GbpD-activated Rap1 pathway regulating adhesion and cell polarity in Dictyostelium discoideum.
The Journal of biological chemistry 2006;281(33):23367-76.
2006: Scrima Andrea; Wittinghofer Alfred
Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element.
The EMBO journal 2006;25(12):2940-51.
2006: Thomas Christoph; Weyand Michael; Wittinghofer Alfred; Berken Antje
Purification and crystallization of the catalytic PRONE domain of RopGEF8 and its complex with Rop4 from Arabidopsis thaliana.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 6):607-10.
2006: Kupzig Sabine; Deaconescu Delia; Bouyoucef Dalila; Walker Simon A; Liu Qing; Polte Christian L; Daumke Oliver; Ishizaki Toshimasa; Lockyer Peter J; Wittinghofer Alfred; Cullen Peter J
GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins.
The Journal of biological chemistry 2006;281(15):9891-900.
2006: Ghosh Agnidipta; Praefcke Gerrit J K; Renault Louis; Wittinghofer Alfred; Herrmann Christian
How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP.
Nature 2006;440(7080):101-4.
2006: Kühnel Karin; Veltel Stefan; Schlichting Ilme; Wittinghofer Alfred
Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3.
Structure (London, England : 1993) 2006;14(2):367-78.
2006: Rehmann Holger; Das Joost; Knipscheer Puck; Wittinghofer Alfred; Bos Johannes L
Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state.
Nature 2006;439(7076):625-8.
2006: Wittinghofer Alfred
Phosphoryl transfer in Ras proteins, conclusive or elusive?
Trends in biochemical sciences 2006;31(1):20-3.
2005: Lammers Michael; Rose Rolf; Scrima Andrea; Wittinghofer Alfred
The regulation of mDia1 by autoinhibition and its release by Rho*GTP.
The EMBO journal 2005;24(23):4176-87.
2005: Berken Antje; Thomas Christoph; Wittinghofer Alfred
A new family of RhoGEFs activates the Rop molecular switch in plants.
Nature 2005;436(7054):1176-80.
2005: Farkasovsky Marian; Herter Peter; Voss Beate; Wittinghofer Alfred
Nucleotide binding and filament assembly of recombinant yeast septin complexes.
Biological chemistry 2005;386(7):643-56.
2005: Hanzal-Bayer Michael; Linari Marco; Wittinghofer Alfred
Properties of the interaction of Arf-like protein 2 with PDEdelta.
Journal of molecular biology 2005;350(5):1074-82.
2005: Rose R; Weyand M; Lammers M; Ishizaki T; Ahmadian M R; Wittinghofer A
Structural and mechanistic insights into the interaction between Rho and mammalian Dia.
Nature 2005;435(7041):513-8.
2005: Rocks Oliver; Peyker Anna; Kahms Martin; Verveer Peter J; Koerner Carolin; Lumbierres Maria; Kuhlmann Jürgen; Waldmann Herbert; Wittinghofer Alfred; Bastiaens Philippe I H
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms.
Science (New York, N.Y.) 2005;307(5716):1746-52.
2005: Rose Rolf; Wittinghofer Alfred; Weyand Michael
The purification and crystallization of mDia1 in complex with RhoC.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 2):225-7.
2005: Spoerner Michael; Nuehs Andrea; Ganser Petra; Herrmann Christian; Wittinghofer Alfred; Kalbitzer Hans Robert
Conformational states of Ras complexed with the GTP analogue GppNHp or GppCH2p: implications for the interaction with effector proteins.
Biochemistry 2005;44(6):2225-36.
2005: Gail Robert; Frank Ronald; Wittinghofer Alfred
Systematic peptide array-based delineation of the differential beta-catenin interaction with Tcf4, E-cadherin, and adenomatous polyposis coli.
The Journal of biological chemistry 2005;280(8):7107-17.
2005: Scrima Andrea; Vetter Ingrid R; Armengod M Eugenia; Wittinghofer Alfred
The structure of the TrmE GTP-binding protein and its implications for tRNA modification.
The EMBO journal 2005;24(1):23-33.
2005: Rossbach Michael; Daumke Oliver; Klinger Claudia; Wittinghofer Alfred; Kaufmann Michael
Crystal structure of THEP1 from the hyperthermophile Aquifex aeolicus: a variation of the RecA fold.
BMC structural biology 2005;5():7.
2004: Spoerner Michael; Wittinghofer Alfred; Kalbitzer Hans Robert
Perturbation of the conformational equilibria in Ras by selective mutations as studied by 31P NMR spectroscopy.
FEBS letters 2004;578(3):305-10.
2004: Kühnel Karin; Jarchau Thomas; Wolf Eva; Schlichting Ilme; Walter Ulrich; Wittinghofer Alfred; Strelkov Sergei V
The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(49):17027-32.
2004: Soulère Laurent; Aldrich Courtney; Daumke Oliver; Gail Robert; Kissau Lars; Wittinghofer Alfred; Waldmann Herbert
Synthesis of GTP-derived Ras ligands.
Chembiochem : a European journal of chemical biology 2004;5(10):1448-53.
2004: Chakrabarti Partha P; Suveyzdis Yan; Wittinghofer Alfred; Gerwert Klaus
Fourier transform infrared spectroscopy on the Rap.RapGAP reaction, GTPase activation without an arginine finger.
The Journal of biological chemistry 2004;279(44):46226-33.
2004: Daumke Oliver; Weyand Michael; Chakrabarti Partha P; Vetter Ingrid R; Wittinghofer Alfred
The GTPase-activating protein Rap1GAP uses a catalytic asparagine.
Nature 2004;429(6988):197-201.
2004: Daumke Oliver; Wittinghofer Alfred; Weyand Michael
Purification, crystallization and preliminary structural characterization of human Rap1GAP.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 4):752-4.
2004: Shimada Atsushi; Nyitrai Miklós; Vetter Ingrid R; Kühlmann Dorothee; Bugyi Beáta; Narumiya Shuh; Geeves Michael A; Wittinghofer Alfred
The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization.
Molecular cell 2004;13(4):511-22.
2003: Seewald Michael J; Kraemer Astrid; Farkasovsky Marian; Körner Carolin; Wittinghofer Alfred; Vetter Ingrid R
Biochemical characterization of the Ran-RanBP1-RanGAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction?
Molecular and cellular biology 2003;23(22):8124-36.
2003: Rehmann Holger; Schwede Frank; Døskeland Stein O; Wittinghofer Alfred; Bos Johannes L
Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac.
The Journal of biological chemistry 2003;278(40):38548-56.
2003: Schlumberger Markus C; Friebel Andrea; Buchwald Gretel; Scheffzek Klaus; Wittinghofer Alfred; Hardt Wolf-Dietrich
Amino acids of the bacterial toxin SopE involved in G nucleotide exchange on Cdc42.
The Journal of biological chemistry 2003;278(29):27149-59.
2003: Rehmann Holger; Rueppel Alma; Bos Johannes L; Wittinghofer Alfred
Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac.
The Journal of biological chemistry 2003;278(26):23508-14.
2003: Würtele Martin; Jelich-Ottmann Christian; Wittinghofer Alfred; Oecking Claudia
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex.
The EMBO journal 2003;22(5):987-94.
2003: Kuiperij H Bea; de Rooij Johan; Rehmann Holger; van Triest Miranda; Wittinghofer Alfred; Bos Johannes L; Zwartkruis Fried J T
Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2.
Biochimica et biophysica acta 2003;1593(2-3):141-9.
2003: Rehmann Holger; Prakash Balaji; Wolf Eva; Rueppel Alma; de Rooij Johan; Bos Johannes L; Wittinghofer Alfred
Structure and regulation of the cAMP-binding domains of Epac2.
Nature structural biology 2003;10(1):26-32.
2002: Kraemer Astrid; Brinkmann Thilo; Plettner Ina; Goody Roger; Wittinghofer Alfred
Fluorescently labelled guanine nucleotide binding proteins to analyse elementary steps of GAP-catalysed reactions.
Journal of molecular biology 2002;324(4):763-74.
2002: Wittinghofer Alfred
Obg, a G domain with a beautiful extension.
Structure (London, England : 1993) 2002;10(11):1471-2.
2002: Buchwald Gretel; Friebel Andrea; Galán Jorge E; Hardt Wolf-Dietrich; Wittinghofer Alfred; Scheffzek Klaus
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE.
The EMBO journal 2002;21(13):3286-95.
2002: Hanzal-Bayer Michael; Renault Louis; Roversi Pietro; Wittinghofer Alfred; Hillig Roman C
The complex of Arl2-GTP and PDE delta: from structure to function.
The EMBO journal 2002;21(9):2095-106.
2002: Brinkmann Thilo; Daumke Oliver; Herbrand Ulrike; Kühlmann Dorothee; Stege Patricia; Ahmadian Mohammad Reza; Wittinghofer Alfred
Rap-specific GTPase activating protein follows an alternative mechanism.
The Journal of biological chemistry 2002;277(15):12525-31.
2002: Ahmadian Mohammad Reza; Wittinghofer Alfred; Schmidt Gudula
The actin filament architecture: tightly regulated by the cells, manipulated by pathogens. International Titisee Conference on the actin cytoskeleton: from signalling to bacterial pathogenesis.
EMBO reports 2002;3(3):214-8.
2002: Seewald Michael J; Körner Carolin; Wittinghofer Alfred; Vetter Ingrid R
RanGAP mediates GTP hydrolysis without an arginine finger.
Nature 2002;415(6872):662-6.
2002: Ahmadian Mohammad Reza; Wittinghofer Alfred; Herrmann Christian
Fluorescence methods in the study of small GTP-binding proteins.
Methods in molecular biology (Clifton, N.J.) 2002;189():45-63.
2001: Scheffzek K; Grünewald P; Wohlgemuth S; Kabsch W; Tu H; Wigler M; Wittinghofer A; Herrmann C
The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast.
Structure (London, England : 1993) 2001;9(11):1043-50.
2001: Vetter I R; Wittinghofer A
The guanine nucleotide-binding switch in three dimensions.
Science (New York, N.Y.) 2001;294(5545):1299-304.
2001: Gail R; Costisella B; Ahmadian M R; Wittinghofer A
Ras-mediated cleavage of a GTP analogue by a novel mechanism.
Chembiochem : a European journal of chemical biology 2001;2(7-8):570-5.
2001: Buchwald G; Hostinova E; Rudolph M G; Kraemer A; Sickmann A; Meyer H E; Scheffzek K; Wittinghofer A
Conformational switch and role of phosphorylation in PAK activation.
Molecular and cellular biology 2001;21(15):5179-89.
2001: Allin C; Ahmadian M R; Wittinghofer A; Gerwert K
Monitoring the GAP catalyzed H-Ras GTPase reaction at atomic resolution in real time.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(14):7754-9.
2001: Rudolph M G; Linnemann T; Grunewald P; Wittinghofer A; Vetter I R; Herrmann C
Thermodynamics of Ras/effector and Cdc42/effector interactions probed by isothermal titration calorimetry.
The Journal of biological chemistry 2001;276(26):23914-21.
2001: Renault L; Kuhlmann J; Henkel A; Wittinghofer A
Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1).
Cell 2001;105(2):245-55.
2001: Spoerner M; Herrmann C; Vetter I R; Kalbitzer H R; Wittinghofer A
Dynamic properties of the Ras switch I region and its importance for binding to effectors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):4944-9.
2001: Kraemer A; Rehmann H R; Cool R H; Theiss C; de Rooij J; Bos J L; Wittinghofer A
Dynamic interaction of cAMP with the Rap guanine-nucleotide exchange factor Epac1.
Journal of molecular biology 2001;306(5):1167-77.
2001: Rohrer M; Prisner T F; Brügmann O; Käss H; Spoerner M; Wittinghofer A; Kalbitzer H R
Structure of the metal-water complex in Ras x GDP studied by high-field EPR spectroscopy and 31P NMR spectroscopy.
Biochemistry 2001;40(7):1884-9.
2001: Würtele M; Renault L; Barbieri J T; Wittinghofer A; Wolf E
Structure of the ExoS GTPase activating domain.
FEBS letters 2001;491(1-2):26-9.
2001: Würtele M; Wolf E; Pederson K J; Buchwald G; Ahmadian M R; Barbieri J T; Wittinghofer A
How the Pseudomonas aeruginosa ExoS toxin downregulates Rac.
Nature structural biology 2001;8(1):23-6.
2000: Hillig R C; Hanzal-Bayer M; Linari M; Becker J; Wittinghofer A; Renault L
Structural and biochemical properties show ARL3-GDP as a distinct GTP binding protein.
Structure (London, England : 1993) 2000;8(12):1239-45.
2000: Klockow B; Ahmadian M R; Block C; Wittinghofer A
Oncogenic insertional mutations in the P-loop of Ras are overactive in MAP kinase signaling.
Oncogene 2000;19(47):5367-76.
2000: Villa Braslavsky C I; Nowak C; Görlich D; Wittinghofer A; Kuhlmann J
Different structural and kinetic requirements for the interaction of Ran with the Ran-binding domains from RanBP2 and importin-beta.
Biochemistry 2000;39(38):11629-39.
2000: Prakash B; Renault L; Praefcke G J; Herrmann C; Wittinghofer A
Triphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanism.
The EMBO journal 2000;19(17):4555-64.
2000: de Bruyn K M; de Rooij J; Wolthuis R M; Rehmann H; Wesenbeek J; Cool R H; Wittinghofer A H; Bos J L
RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral.
The Journal of biological chemistry 2000;275(38):29761-6.
2000: de Rooij J; Rehmann H; van Triest M; Cool R H; Wittinghofer A; Bos J L
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.
The Journal of biological chemistry 2000;275(27):20829-36.
2000: Schmidt G; Wittinghofer A
Priming of PC12 cells for semiquantitative microinjection studies involving Ras.
FEBS letters 2000;474(2-3):184-8.
2000: Huber F; Gronwald W; Wohlgemuth S; Herrmann C; Geyer M; Wittinghofer A; Kalbitzer H R
Sequential NMR assignment of the RAS-binding domain of Byr2.
Journal of biomolecular NMR 2000;16(4):355-6.
2000: Prakash B; Praefcke G J; Renault L; Wittinghofer A; Herrmann C
Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins.
Nature 2000;403(6769):567-71.
2000: Bader B; Kuhn K; Owen D J; Waldmann H; Wittinghofer A; Kuhlmann J
Bioorganic synthesis of lipid-modified proteins for the study of signal transduction.
Nature 2000;403(6766):223-6.
1999: de Rooij J; Boenink N M; van Triest M; Cool R H; Wittinghofer A; Bos J L
PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2.
The Journal of biological chemistry 1999;274(53):38125-30.
1999: Cool R H; Schmidt G; Lenzen C U; Prinz H; Vogt D; Wittinghofer A
The Ras mutant D119N is both dominant negative and activated.
Molecular and cellular biology 1999;19(9):6297-305.
1999: Hillig R C; Renault L; Vetter I R; Drell T; Wittinghofer A; Becker J
The crystal structure of rna1p: a new fold for a GTPase-activating protein.
Molecular cell 1999;3(6):781-91.
1999: Bauer B; Mirey G; Vetter I R; García-Ranea J A; Valencia A; Wittinghofer A; Camonis J H; Cool R H
Effector recognition by the small GTP-binding proteins Ras and Ral.
The Journal of biological chemistry 1999;274(25):17763-70.
1999: Ahmadian M R; Zor T; Vogt D; Kabsch W; Selinger Z; Wittinghofer A; Scheffzek K
Guanosine triphosphatase stimulation of oncogenic Ras mutants.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):7065-70.
1999: Vetter I R; Linnemann T; Wohlgemuth S; Geyer M; Kalbitzer H R; Herrmann C; Wittinghofer A
Structural and biochemical analysis of Ras-effector signaling via RalGDS.
FEBS letters 1999;451(2):175-80.
1999: Vetter I R; Arndt A; Kutay U; Görlich D; Wittinghofer A
Structural view of the Ran-Importin beta interaction at 2.3 A resolution.
Cell 1999;97(5):635-46.
1999: Linnemann T; Geyer M; Jaitner B K; Block C; Kalbitzer H R; Wittinghofer A; Herrmann C
Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily.
The Journal of biological chemistry 1999;274(19):13556-62.
1999: Rudolph M G; Wittinghofer A; Vetter I R
Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: two different nucleotide states in one crystal.
Protein science : a publication of the Protein Society 1999;8(4):778-87.
1999: van den Berghe N; Cool R H; Wittinghofer A
Discriminatory residues in Ras and Rap for guanine nucleotide exchange factor recognition.
The Journal of biological chemistry 1999;274(16):11078-85.
1999: Vetter I R; Nowak C; Nishimoto T; Kuhlmann J; Wittinghofer A
Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport.
Nature 1999;398(6722):39-46.
1999: Renault L; Nassar N; Wittinghofer A; Roth M; Vetter I R
Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):272-5.
1999: Herter P; Kuhnen C; Müller K M; Wittinghofer A; Müller O
Intracellular distribution of beta-catenin in colorectal adenomas, carcinomas and Peutz-Jeghers polyps.
Journal of cancer research and clinical oncology 1999;125(5):297-304.
1998: de Rooij J; Zwartkruis F J; Verheijen M H; Cool R H; Nijman S M; Wittinghofer A; Bos J L
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.
Nature 1998;396(6710):474-7.
1998: Daub M; Jöckel J; Quack T; Weber C K; Schmitz F; Rapp U R; Wittinghofer A; Block C
The RafC1 cysteine-rich domain contains multiple distinct regulatory epitopes which control Ras-dependent Raf activation.
Molecular and cellular biology 1998;18(11):6698-710.
1998: Esser D; Bauer B; Wolthuis R M; Wittinghofer A; Cool R H; Bayer P
Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf.
Biochemistry 1998;37(39):13453-62.
1998: Wittinghofer A
Signal transduction via Ras.
Biological chemistry 1998;379(8-9):933-7.
1998: Scheffzek K; Ahmadian M R; Wiesmüller L; Kabsch W; Stege P; Schmitz F; Wittinghofer A
Structural analysis of the GAP-related domain from neurofibromin and its implications.
The EMBO journal 1998;17(15):4313-27.
1998: Scheffzek K; Ahmadian M R; Wittinghofer A
GTPase-activating proteins: helping hands to complement an active site.
Trends in biochemical sciences 1998;23(7):257-62.
1998: Rudolph M G; Bayer P; Abo A; Kuhlmann J; Vetter I R; Wittinghofer A
The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation.
The Journal of biological chemistry 1998;273(29):18067-76.
1998: Lenzen C; Cool R H; Prinz H; Kuhlmann J; Wittinghofer A
Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25Mm.
Biochemistry 1998;37(20):7420-30.
1998: Renault L; Nassar N; Vetter I; Becker J; Klebe C; Roth M; Wittinghofer A
The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller.
Nature 1998;392(6671):97-101.
1997: Wittinghofer A
Signaling mechanistics: aluminum fluoride for molecule of the year.
Current biology : CB 1997;7(11):R682-5.
1997: Jaitner B K; Becker J; Linnemann T; Herrmann C; Wittinghofer A; Block C
Discrimination of amino acids mediating Ras binding from noninteracting residues affecting raf activation by double mutant analysis.
The Journal of biological chemistry 1997;272(47):29927-33.
1997: Kuhlmann J; Macara I; Wittinghofer A
Dynamic and equilibrium studies on the interaction of Ran with its effector, RanBP1.
Biochemistry 1997;36(40):12027-35.
1997: Geyer M; Herrmann C; Wohlgemuth S; Wittinghofer A; Kalbitzer H R
Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling.
Nature structural biology 1997;4(9):694-9.
1997: Ahmadian M R; Stege P; Scheffzek K; Wittinghofer A
Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras.
Nature structural biology 1997;4(9):686-9.
1997: van den Berghe N; Cool R H; Horn G; Wittinghofer A
Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N).
Oncogene 1997;15(7):845-50.
1997: Scheffzek K; Ahmadian M R; Kabsch W; Wiesmüller L; Lautwein A; Schmitz F; Wittinghofer A
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.
Science (New York, N.Y.) 1997;277(5324):333-8.
1997: Wittinghofer A; Scheffzek K; Ahmadian M R
The interaction of Ras with GTPase-activating proteins.
FEBS letters 1997;410(1):63-7.
1997: Ahmadian M R; Mittal R; Hall A; Wittinghofer A
Aluminum fluoride associates with the small guanine nucleotide binding proteins.
FEBS letters 1997;408(3):315-8.
1997: Ahmadian M R; Hoffmann U; Goody R S; Wittinghofer A
Individual rate constants for the interaction of Ras proteins with GTPase-activating proteins determined by fluorescence spectroscopy.
Biochemistry 1997;36(15):4535-41.
1997: Schweins T; Scheffzek K; Assheuer R; Wittinghofer A
The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+.
Journal of molecular biology 1997;266(4):847-56.
1997: Scheffzek K; Lautwein A; Scherer A; Franken S; Wittinghofer A
Crystallization and preliminary X-ray crystallographic study of the Ras-GTPase-activating domain of human p120GAP.
Proteins 1997;27(2):315-8.
1996: Wittinghofer A; Nassar N
How Ras-related proteins talk to their effectors.
Trends in biochemical sciences 1996;21(12):488-91.
1996: Scheffzek K; Lautwein A; Kabsch W; Ahmadian M R; Wittinghofer A
Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras.
Nature 1996;384(6609):591-6.
1996: Schweins T; Geyer M; Kalbitzer H R; Wittinghofer A; Warshel A
Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras.
Biochemistry 1996;35(45):14225-31.
1996: Geyer M; Schweins T; Herrmann C; Prisner T; Wittinghofer A; Kalbitzer H R
Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP.
Biochemistry 1996;35(32):10308-20.
1996: Nassar N; Horn G; Herrmann C; Block C; Janknecht R; Wittinghofer A
Ras/Rap effector specificity determined by charge reversal.
Nature structural biology 1996;3(8):723-9.
1996: Wolthuis R M; Bauer B; van 't Veer L J; de Vries-Smits A M; Cool R H; Spaargaren M; Wittinghofer A; Burgering B M; Bos J L
RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.
Oncogene 1996;13(2):353-62.
1996: Ahmadian M R; Wiesmüller L; Lautwein A; Bischoff F R; Wittinghofer A
Structural differences in the minimal catalytic domains of the GTPase-activating proteins p120GAP and neurofibromin.
The Journal of biological chemistry 1996;271(27):16409-15.
1996: Mittal R; Ahmadian M R; Goody R S; Wittinghofer A
Formation of a transition-state analog of the Ras GTPase reaction by Ras-GDP, tetrafluoroaluminate, and GTPase-activating proteins.
Science (New York, N.Y.) 1996;273(5271):115-7.
1996: Herrmann C; Horn G; Spaargaren M; Wittinghofer A
Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor.
The Journal of biological chemistry 1996;271(12):6794-800.
1996: Block C; Janknecht R; Herrmann C; Nassar N; Wittinghofer A
Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo.
Nature structural biology 1996;3(3):244-51.
1996: Schmidt G; Lenzen C; Simon I; Deuter R; Cool R H; Goody R S; Wittinghofer A
Biochemical and biological consequences of changing the specificity of p21ras from guanosine to xanthosine nucleotides.
Oncogene 1996;12(1):87-96.
1995: Block C; Wittinghofer A
Switching to Rac and Rho.
Structure (London, England : 1993) 1995;3(12):1281-4.
1995: Klebe C; Prinz H; Wittinghofer A; Goody R S
The kinetic mechanism of Ran--nucleotide exchange catalyzed by RCC1.
Biochemistry 1995;34(39):12543-52.
1995: Scheidig A J; Franken S M; Corrie J E; Reid G P; Wittinghofer A; Pai E F; Goody R S
X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
Journal of molecular biology 1995;253(1):132-50.
1995: Wittinghofer A; Herrmann C
Ras-effector interactions, the problem of specificity.
FEBS letters 1995;369(1):52-6.
1995: Nassar N; Horn G; Herrmann C; Scherer A; McCormick F; Wittinghofer A
The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue.
Nature 1995;375(6532):554-60.
1995: Becker J; Melchior F; Gerke V; Bischoff F R; Ponstingl H; Wittinghofer A
RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae.
The Journal of biological chemistry 1995;270(20):11860-5.
1995: Wiesmüller L; Scheffzek K; Kliche W; Goody R S; Wittinghofer A; Reinstein J
Crystallization and preliminary X-ray analysis of UMP/CMP-kinase from Dictyostelium discoideum with the specific bisubstrate inhibitor P1-(adenosine 5')-P5-(uridine 5')-pentaphosphate (UP5A).
FEBS letters 1995;363(1-2):22-4.
1995: Scheffzek K; Klebe C; Fritz-Wolf K; Kabsch W; Wittinghofer A
Crystal structure of the nuclear Ras-related protein Ran in its GDP-bound form.
Nature 1995;374(6520):378-81.
1995: Herrmann C; Martin G A; Wittinghofer A
Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase.
The Journal of biological chemistry 1995;270(7):2901-5.
1995: Klebe C; Bischoff F R; Ponstingl H; Wittinghofer A
Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1.
Biochemistry 1995;34(2):639-47.
1995: Rensland H; John J; Linke R; Simon I; Schlichting I; Wittinghofer A; Goody R S
Substrate and product structural requirements for binding of nucleotides to H-ras p21: the mechanism of discrimination between guanosine and adenosine nucleotides.
Biochemistry 1995;34(2):593-9.
1995: Schweins T; Geyer M; Scheffzek K; Warshel A; Kalbitzer H R; Wittinghofer A
Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.
Nature structural biology 1995;2(1):36-44.
1995: Lenzen C; Cool R H; Wittinghofer A
Analysis of intrinsic and CDC25-stimulated guanine nucleotide exchange of p21ras-nucleotide complexes by fluorescence measurements.
Methods in enzymology 1995;255():95-109.
1994: Scheidig A J; Sanchez-Llorente A; Lautwein A; Pai E F; Corrie J E; Reid G P; Wittinghofer A; Goody R S
Crystallographic studies on p21(H-ras) using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 4):512-20.
1994: Schweins T; Wittinghofer A
GTP-binding proteins. Structures, interactions and relationships.
Current biology : CB 1994;4(6):547-50.
1994: Bischoff F R; Klebe C; Kretschmer J; Wittinghofer A; Ponstingl H
RanGAP1 induces GTPase activity of nuclear Ras-related Ran.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2587-91.
1994: Frech M; Darden T A; Pedersen L G; Foley C K; Charifson P S; Anderson M W; Wittinghofer A
Role of glutamine-61 in the hydrolysis of GTP by p21H-ras: an experimental and theoretical study.
Biochemistry 1994;33(11):3237-44.
1994: Wittinghofer A
The structure of transducin G alpha t: more to view than just ras.
Cell 1994;76(2):201-4.
1993: Wittinghofer A
From EF-Tu to p21ras and back again.
Current biology : CB 1993;3(12):874-6.
1993: John J; Rensland H; Schlichting I; Vetter I; Borasio G D; Goody R S; Wittinghofer A
Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras.
The Journal of biological chemistry 1993;268(2):923-9.
1993: Wittinghofer A; Franken S M; Scheidig A J; Rensland H; Lautwein A; Pai E F; Goody R S
Three-dimensional structure and properties of wild-type and mutant H-ras-encoded p21.
Ciba Foundation symposium 1993;176():6-21; discussion 21-7.
1992: Wolber V; Maeda K; Schumann R; Brandmeier B; Wiesmüller L; Wittinghofer A
A universal expression-purification system based on the coiled-coil interaction of myosin heavy chain.
Bio/technology (Nature Publishing Company) 1992;10(8):900-4.
1992: Serth J; Weber W; Frech M; Wittinghofer A; Pingoud A
Binding of the H-ras p21 GTPase activating protein by the activated epidermal growth factor receptor leads to inhibition of the p21 GTPase activity in vitro.
Biochemistry 1992;31(28):6361-5.
1992: Mistou M Y; Jacquet E; Poullet P; Rensland H; Gideon P; Schlichting I; Wittinghofer A; Parmeggiani A
Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator.
The EMBO journal 1992;11(7):2391-7.
1992: Müller O; Frech M; Gideon P; Wittinghofer A; Schwarz M
Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice.
Oncogene 1992;7(7):1407-12.
1992: Foley C K; Pedersen L G; Charifson P S; Darden T A; Wittinghofer A; Pai E F; Anderson M W
Simulation of the solution structure of the H-ras p21-GTP complex.
Biochemistry 1992;31(21):4951-9.
1992: Wiesmüller L; Wittinghofer A
Expression of the GTPase activating domain of the neurofibromatosis type 1 (NF1) gene in Escherichia coli and role of the conserved lysine residue.
The Journal of biological chemistry 1992;267(15):10207-10.
1992: Gideon P; John J; Frech M; Lautwein A; Clark R; Scheffler J E; Wittinghofer A
Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity.
Molecular and cellular biology 1992;12(5):2050-6.
1992: Wolber V; Rensland H; Brandmeier B; Sagemann M; Hoffmann R; Kalbitzer H R; Wittinghofer A
Expression, purification and biochemical characterisation of the human immunodeficiency virus 1 nef gene product.
European journal of biochemistry / FEBS 1992;205(3):1115-21.
1992: Goody R S; Pai E F; Schlichting I; Rensland H; Scheidig A; Franken S; Wittinghofer A
Studies on the structure and mechanism of H-ras p21.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1992;336(1276):3-10; discussion 10-1.
1991: Rensland H; Lautwein A; Wittinghofer A; Goody R S
Is there a rate-limiting step before GTP cleavage by H-ras p21?
Biochemistry 1991;30(46):11181-5.
1991: Wittinghofer A; Pai E F
The structure of Ras protein: a model for a universal molecular switch.
Trends in biochemical sciences 1991;16(10):382-7.
1991: Reinstein J; Schlichting I; Frech M; Goody R S; Wittinghofer A
p21 with a phenylalanine 28----leucine mutation reacts normally with the GTPase activating protein GAP but nevertheless has transforming properties.
The Journal of biological chemistry 1991;266(26):17700-6.
1991: Kalbitzer H R; Maeda K; Rösch A; Maéda Y; Geyer M; Beneicke W; Neidig K P; Wittinghofer A
C-terminal structure and mobility of rabbit skeletal muscle light meromyosin as studied by one- and two-dimensional 1H NMR spectroscopy and X-ray small-angle scattering.
Biochemistry 1991;30(32):8083-91.
1991: Serth J; Lautwein A; Frech M; Wittinghofer A; Pingoud A
The inhibition of the GTPase activating protein-Ha-ras interaction by acidic lipids is due to physical association of the C-terminal domain of the GTPase activating protein with micellar structures.
The EMBO journal 1991;10(6):1325-30.
1991: Kalbitzer H R; Wittinghofer A
The effect of kirromycin on the metal ion coordination in complexes of elongation factor Tu from Bacillus stearothermophilus as inferred from the 17O-55Mn superhyperfine interaction.
Biochimica et biophysica acta 1991;1078(2):133-8.
1991: Maeda K; Rösch A; Maéda Y; Kalbitzer H R; Wittinghofer A
Rabbit skeletal muscle myosin. Unfolded carboxyl-terminus and its role in molecular assembly.
FEBS letters 1991;281(1-2):23-6.
1991: Bock-Möbius I; Brune M; Wittinghofer A; Zimmermann H; Leberman R; Dauvergne M T; Zimmermann S; Brandmeier B; Rösch P
Identification of valine/leucine/isoleucine and threonine/alanine/glycine proton-spin systems of Escherichia coli adenylate kinase by selective deuteration and selective protonation.
The Biochemical journal 1991;273(Pt 2)():311-6.
1990: Reinstein J; Schlichting I; Wittinghofer A
Structurally and catalytically important residues in the phosphate binding loop of adenylate kinase of Escherichia coli.
Biochemistry 1990;29(32):7451-9.
1990: Reinstein J; Vetter I R; Schlichting I; Rösch P; Wittinghofer A; Goody R S
Fluorescence and NMR investigations on the ligand binding properties of adenylate kinases.
Biochemistry 1990;29(32):7440-50.
1990: Krengel U; Schlichting I; Scherer A; Schumann R; Frech M; John J; Kabsch W; Pai E F; Wittinghofer A
Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell 1990;62(3):539-48.
1990: Pai E F; Krengel U; Petsko G A; Goody R S; Kabsch W; Wittinghofer A
Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.
The EMBO journal 1990;9(8):2351-9.
1990: Frech M; John J; Pizon V; Chardin P; Tavitian A; Clark R; McCormick F; Wittinghofer A
Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product.
Science (New York, N.Y.) 1990;249(4965):169-71.
1990: John J; Sohmen R; Feuerstein J; Linke R; Wittinghofer A; Goody R S
Kinetics of interaction of nucleotides with nucleotide-free H-ras p21.
Biochemistry 1990;29(25):6058-65.
1990: Schlichting I; Almo S C; Rapp G; Wilson K; Petratos K; Lentfer A; Wittinghofer A; Kabsch W; Pai E F; Petsko G A
Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis.
Nature 1990;345(6273):309-15.
1990: Frech M; Schlichting I; Wittinghofer A; Chardin P
Guanine nucleotide binding properties of the mammalian RalA protein produced in Escherichia coli.
The Journal of biological chemistry 1990;265(11):6353-9.
1990: Kalbitzer H R; Feuerstein J; Goody R S; Wittinghofer A
Stereochemistry and lifetime of the GTP hydrolysis intermediate at the active site of elongation factor Tu from Bacillus stearothermophilus as inferred from the 17O-55Mn superhyperfine interaction.
European journal of biochemistry / FEBS 1990;188(2):355-9.
1990: Schlichting I; John J; Frech M; Chardin P; Wittinghofer A; Zimmermann H; Rösch P
Proton NMR studies of transforming and nontransforming H-ras p21 mutants.
Biochemistry 1990;29(2):504-11.
1989: Schlichting I; Rapp G; John J; Wittinghofer A; Pai E F; Goody R S
Biochemical and crystallographic characterization of a complex of c-Ha-ras p21 and caged GTP with flash photolysis.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7687-90.
1989: Pai E F; Kabsch W; Krengel U; Holmes K C; John J; Wittinghofer A
Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation.
Nature 1989;341(6239):209-14.
1989: John J; Schlichting I; Schiltz E; Rösch P; Wittinghofer A
C-terminal truncation of p21H preserves crucial kinetic and structural properties.
The Journal of biological chemistry 1989;264(22):13086-92.
1989: Haase G H; Brune M; Reinstein J; Pai E F; Pingoud A; Wittinghofer A
Adenylate kinases from thermosensitive Escherichia coli strains.
Journal of molecular biology 1989;207(1):151-62.
1988: Pingoud A; Wehrmann M; Pieper U; Gast F U; Urbanke C; Alves J; Feuerstein J; Wittinghofer A
Spectroscopic and hydrodynamic studies reveal structural differences in normal and transforming H-ras gene products.
Biochemistry 1988;27(13):4735-40.
1988: Reinstein J; Brune M; Wittinghofer A
Mutations in the nucleotide binding loop of adenylate kinase of Escherichia coli.
Biochemistry 1988;27(13):4712-20.
1988: Bock I; Reinstein J; Brune M; Wittinghofer A; Rösch P
Proton-nuclear magnetic resonance studies of the aromatic spin systems of Escherichia coli adenylate kinase.
Journal of molecular biology 1988;200(4):745-8.
1988: Schlichting I; Wittinghofer A; Rösch P
Proton NMR studies of the GDP.Mg2+ complex of the Ha-ras oncogene product p21.
Biochemical and biophysical research communications 1988;150(1):444-8.
1987: Feuerstein J; Kalbitzer H R; John J; Goody R S; Wittinghofer A
Characterisation of the metal-ion-GDP complex at the active sites of transforming and nontransforming p21 proteins by observation of the 17O-Mn superhyperfine coupling and by kinetic methods.
European journal of biochemistry / FEBS 1987;162(1):49-55.

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