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Sergio Wittlin
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Research Profile (preview)
Chemicals & Drugs
Living Beings
Procedures
Disorders
Concepts & Ideas
Physiology
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Network (preview)
12
Matile, Hugues
11
Scheurer, Christian
11
Brun, Reto
10
Charman, Susan
10
Vennerstrom, Jonathan
9
Chollet, Jacques
9
Dong, Yuxiang
6
Charman, William
6
Lindeman, Geoffrey
6
Visvader, Jane
6
Wang, Xiaofang
4
Snyder, Christopher
4
Sutherland, Kate
4
Tang, Yuanqing
4
Scorneaux, Bernard
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Publications
- Wang Xiaofang; Creek Darren J; Schiaffo Charles E; Dong Yuxiang; Chollet Jacques; Scheurer Christian; Wittlin Sergio; Charman Susan A; Dussault Patrick H; Wood James K; Vennerstrom Jonathan L
Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity.
- Tritten Lucienne; Matile Hugues; Brun Reto; Wittlin Sergio
A new double-antibody sandwich ELISA targeting Plasmodium falciparum aldolase to evaluate anti-malarial drug sensitivity.
- Hofer Sandra; Brun Reto; Maerki Sonja; Matile Hugues; Scheurer Christian; Wittlin Sergio
In vitro assessment of the pharmacodynamic properties of DB75, piperaquine, OZ277 and OZ401 in cultures of Plasmodium falciparum.
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Geonetwork of Sergio Wittlin (preview)
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All Publications
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2009: Wang Xiaofang; Creek Darren J; Schiaffo Charles E; Dong Yuxiang; Chollet Jacques; Scheurer Christian; Wittlin Sergio; Charman Susan A; Dussault Patrick H; Wood James K; Vennerstrom Jonathan L
Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity.
Bioorganic & medicinal chemistry letters 2009;19(16):4542-5.
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2009: Tritten Lucienne; Matile Hugues; Brun Reto; Wittlin Sergio
A new double-antibody sandwich ELISA targeting Plasmodium falciparum aldolase to evaluate anti-malarial drug sensitivity.
Malaria journal 2009;8():226.
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2008: Hofer Sandra; Brun Reto; Maerki Sonja; Matile Hugues; Scheurer Christian; Wittlin Sergio
In vitro assessment of the pharmacodynamic properties of DB75, piperaquine, OZ277 and OZ401 in cultures of Plasmodium falciparum.
The Journal of antimicrobial chemotherapy 2008;62(5):1061-4.
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2008: Li Jia V; Wang Yulan; Saric Jasmina; Nicholson Jeremy K; Dirnhofer Stephan; Singer Burton H; Tanner Marcel; Wittlin Sergio; Holmes Elaine; Utzinger Jürg
Global metabolic responses of NMRI mice to an experimental Plasmodium berghei infection.
Journal of proteome research 2008;7(9):3948-56.
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2008: Sparatore Anna; Basilico Nicoletta; Casagrande Manolo; Parapini Silvia; Taramelli Donatella; Brun Reto; Wittlin Sergio; Sparatore Fabio
Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline.
Bioorganic & medicinal chemistry letters 2008;18(13):3737-40.
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2008: Ge Jian-Feng; Arai Chika; Kaiser Marcel; Wittlin Sergio; Brun Reto; Ihara Masataka
Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive 3,7-bis(dialkylamino)phenoxazin-5-ium derivatives.
Journal of medicinal chemistry 2008;51(12):3654-8.
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2008: Zhou Lin; Alker André; Ruf Armin; Wang Xiaofang; Chiu Francis C K; Morizzi Julia; Charman Susan A; Charman William N; Scheurer Christian; Wittlin Sergio; Dong Yuxiang; Hunziker Daniel; Vennerstrom Jonathan L
Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277.
Bioorganic & medicinal chemistry letters 2008;18(5):1555-8.
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2008: Posner Gary H; Chang Wonsuk; Hess Lindsey; Woodard Lauren; Sinishtaj Sandra; Usera Aimee R; Maio William; Rosenthal Andrew S; Kalinda Alvin S; D'Angelo John G; Petersen Kimberly S; Stohler Remo; Chollet Jacques; Santo-Tomas Josefina; Snyder Christopher; Rottmann Matthias; Wittlin Sergio; Brun Reto; Shapiro Theresa A
Malaria-infected mice are cured by oral administration of new artemisinin derivatives.
Journal of medicinal chemistry 2008;51(4):1035-42.
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2007: Wang Xiaofang; Dong Yuxiang; Wittlin Sergio; Creek Darren; Chollet Jacques; Charman Susan A; Tomas Josefina Santo; Scheurer Christian; Snyder Christopher; Vennerstrom Jonathan L
Spiro- and dispiro-1,2-dioxolanes: contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides.
Journal of medicinal chemistry 2007;50(23):5840-7.
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2007: Kaiser Marcel; Wittlin Sergio; Nehrbass-Stuedli Angela; Dong Yuxiang; Wang Xiaofang; Hemphill Andrew; Matile Hugues; Brun Reto; Vennerstrom Jonathan L
Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).
Antimicrobial agents and chemotherapy 2007;51(8):2991-3.
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2007: Dong Yuxiang; Creek Darren; Chollet Jacques; Matile Hugues; Charman Susan A; Wittlin Sergio; Wood James K; Vennerstrom Jonathan L
Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).
Antimicrobial agents and chemotherapy 2007;51(8):3033-5.
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2007: Osorio Lyda; Murillo Claribel; Aponte Samanda; Mayagaya Valeriana; Scheurer Christian; Brun Reto; Matile Hugues; Wittlin Sergio
In vitro susceptibility of P. falciparum populations from Colombia and Tanzania to a new synthetic peroxide (OZ277).
The American journal of tropical medicine and hygiene 2007;76(6):1024-6.
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2007: Tang Yuanqing; Dong Yuxiang; Wittlin Sergio; Charman Susan A; Chollet Jacques; Chiu Francis C K; Charman William N; Matile Hugues; Urwyler Heinrich; Dorn Arnulf; Bajpai Saroj; Wang Xiaofang; Padmanilayam Maniyan; Karle Jean M; Brun Reto; Vennerstrom Jonathan L
Weak base dispiro-1,2,4-trioxolanes: potent antimalarial ozonides.
Bioorganic & medicinal chemistry letters 2007;17(5):1260-5.
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2007: Snyder Christopher; Chollet Jacques; Santo-Tomas Josefina; Scheurer Christian; Wittlin Sergio
In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models.
Experimental parasitology 2007;115(3):296-300.
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2007: Uhlemann Anne-Catrin; Wittlin Sergio; Matile Hugues; Bustamante Leyla Y; Krishna Sanjeev
Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277).
Antimicrobial agents and chemotherapy 2007;51(2):667-72.
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2006: Padmanilayam Maniyan; Scorneaux Bernard; Dong Yuxiang; Chollet Jacques; Matile Hugues; Charman Susan A; Creek Darren J; Charman William N; Tomas Josefina Santo; Scheurer Christian; Wittlin Sergio; Brun Reto; Vennerstrom Jonathan L
Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine.
Bioorganic & medicinal chemistry letters 2006;16(21):5542-5.
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2006: Dong Yuxiang; Tang Yuanqing; Chollet Jacques; Matile Hugues; Wittlin Sergio; Charman Susan A; Charman William N; Tomas Josefina Santo; Scheurer Christian; Snyder Christopher; Scorneaux Bernard; Bajpai Saroj; Alexander Scott A; Wang Xiaofang; Padmanilayam Maniyan; Cheruku Srinivasa R; Brun Reto; Vennerstrom Jonathan L
Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes.
Bioorganic & medicinal chemistry 2006;14(18):6368-82.
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2006: Maerki Sonja; Brun Reto; Charman Susan A; Dorn Arnulf; Matile Hugues; Wittlin Sergio
In vitro assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of Plasmodium falciparum.
The Journal of antimicrobial chemotherapy 2006;58(1):52-8.
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2006: Kocken Clemens H M; van der Wel Annemarie; Arbe-Barnes Sarah; Brun Reto; Matile Hugues; Scheurer Christian; Wittlin Sergio; Thomas Alan W
Plasmodium vivax: in vitro susceptibility of blood stages to synthetic trioxolane compounds and the diamidine DB75.
Experimental parasitology 2006;113(3):197-200.
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2006: Harris Jessica; Stanford Prudence M; Sutherland Kate; Oakes Samantha R; Naylor Matthew J; Robertson Fiona G; Blazek Katrina D; Kazlauskas Michael; Hilton Heidi N; Wittlin Sergio; Alexander Warren S; Lindeman Geoffrey J; Visvader Jane E; Ormandy Christopher J
Socs2 and elf5 mediate prolactin-induced mammary gland development.
Molecular endocrinology (Baltimore, Md.) 2006;20(5):1177-87.
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2005: Dong Yuxiang; Chollet Jacques; Matile Hugues; Charman Susan A; Chiu Francis C K; Charman William N; Scorneaux Bernard; Urwyler Heinrich; Santo Tomas Josefina; Scheurer Christian; Snyder Christopher; Dorn Arnulf; Wang Xiaofang; Karle Jean M; Tang Yuanqing; Wittlin Sergio; Brun Reto; Vennerstrom Jonathan L
Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.
Journal of medicinal chemistry 2005;48(15):4953-61.
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2004: Sutherland Kate D; Lindeman Geoffrey J; Choong David Y H; Wittlin Sergio; Brentzell Luci; Phillips Wayne; Campbell Ian G; Visvader Jane E
Differential hypermethylation of SOCS genes in ovarian and breast carcinomas.
Oncogene 2004;23(46):7726-33.
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2004: Vennerstrom Jonathan L; Arbe-Barnes Sarah; Brun Reto; Charman Susan A; Chiu Francis C K; Chollet Jacques; Dong Yuxiang; Dorn Arnulf; Hunziker Daniel; Matile Hugues; McIntosh Kylie; Padmanilayam Maniyan; Santo Tomas Josefina; Scheurer Christian; Scorneaux Bernard; Tang Yuanqing; Urwyler Heinrich; Wittlin Sergio; Charman William N
Identification of an antimalarial synthetic trioxolane drug development candidate.
Nature 2004;430(7002):900-4.
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2003: Wittlin Sergio; Sutherland Kate D; Visvader Jane E; Lindeman Geoffrey J
Identification of Taxreb107 as a lactogenic hormone responsive gene in mammary epithelial cells.
Biochimica et biophysica acta 2003;1642(3):139-47.
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2003: Wittlin Sergio; Sum Eleanor Y M; Jonas Nadeen K; Lindeman Geoffrey J; Visvader Jane E
Two promoters within the human LMO4 gene contribute to its overexpression in breast cancer cells.
Genomics 2003;82(3):280-7.
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2002: Peng Benjamin; Sutherland Kate D; Sum Eleanor Y M; Olayioye Monilola; Wittlin Sergio; Tang Tang K; Lindeman Geoffrey J; Visvader Jane E
CPAP is a novel stat5-interacting cofactor that augments stat5-mediated transcriptional activity.
Molecular endocrinology (Baltimore, Md.) 2002;16(9):2019-33.
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2001: Lindeman G J; Wittlin S; Lada H; Naylor M J; Santamaria M; Zhang J G; Starr R; Hilton D J; Alexander W S; Ormandy C J; Visvader J
SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.
Genes & development 2001;15(13):1631-6.
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