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Myriam Witvrouw

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TOP 3
P Zhan; Myriam Witvrouw; R Z Yan; Erik De Clercq; X Y Liu; M T Molina; Christophe Pannecouque; S Vega
Synthesis and anti-HIV activity of novel 2,4-disubstituted-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine derivatives.
Muriel Billamboz; Fabrice Bailly; Cédric Lion; Christina Calmels; Marie-Line Andréola; Myriam Witvrouw; Frauke Christ; zeger debyser; Laura De Luca; Alba Chimirri; Philippe Cotelle
2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4.
Cédric Maurin; Cédric Lion; Fabrice Bailly; Nadia Touati; Hervé Vezin; Gladys Mbemba; Jean-François Mouscadet; zeger debyser; Myriam Witvrouw; Philippe Cotelle
New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase--discovery of a new polyhydroxylated antiviral agent.

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All Publications

2011: P Zhan; Myriam Witvrouw; R Z Yan; Erik De Clercq; X Y Liu; M T Molina; Christophe Pannecouque; S Vega
Synthesis and anti-HIV activity of novel 2,4-disubstituted-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine derivatives.
Drug discoveries & therapeutics 2011;5(6):279-85.
2011: Muriel Billamboz; Fabrice Bailly; Cédric Lion; Christina Calmels; Marie-Line Andréola; Myriam Witvrouw; Frauke Christ; zeger debyser; Laura De Luca; Alba Chimirri; Philippe Cotelle
2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4.
European journal of medicinal chemistry 2011;46(2):535-46.
2010: Cédric Maurin; Cédric Lion; Fabrice Bailly; Nadia Touati; Hervé Vezin; Gladys Mbemba; Jean-François Mouscadet; zeger debyser; Myriam Witvrouw; Philippe Cotelle
New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase--discovery of a new polyhydroxylated antiviral agent.
Bioorganic & medicinal chemistry 2010;18(14):5194-201.
2009: Suvi Rajamaki; Anna Innitzer; Chiara Falciani; Cristina Tintori; Frauke Christ; Myriam Witvrouw; zeger debyser; Silvio Massa; Maurizio Botta
Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(13):3615-8.
2008: Muriel Billamboz; Fabrice Bailly; Maria Letizia Barreca; Laura De Luca; Jean-François Mouscadet; Christina Calmels; Marie-Line Andréola; Myriam Witvrouw; Frauke Christ; zeger debyser; Philippe Cotelle
Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain.
Journal of medicinal chemistry 2008;51(24):7717-30.
2008: Clémence Queffélec; Fabrice Bailly; Gladys Mbemba; Jean-François Mouscadet; zeger debyser; Myriam Witvrouw; Philippe Cotelle
The total synthesis of fukiic acid, an HIV-1 integrase inhibitor.
European journal of medicinal chemistry 2008;43(10):2268-71.
2008: Serena Pasquini; Claudia Mugnaini; Cristina Tintori; Maurizio Botta; Alejandro Trejos; Riina K Arvela; Mats Larhed; Myriam Witvrouw; Martine Michiels; Frauke Christ; zeger debyser; Federico Corelli
Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors.
Journal of medicinal chemistry 2008;51(16):5125-9.
2008: Clémence Queffélec; Fabrice Bailly; Gladys Mbemba; Jean-François Mouscadet; Sean Hayes; zeger debyser; Myriam Witvrouw; Philippe Cotelle
Synthesis and antiviral properties of some polyphenols related to Salvia genus.
Bioorganic & medicinal chemistry letters 2008;18(16):4736-40.
2008: Anneleen Hombrouck; Barbara Van Remoortel; Martine Michiels; Wim Noppe; Frauke Christ; Anders Eneroth; Britt Louise Sahlberg; Kurt Benkestock; Lotta Vrang; Nils Gunnar Johansson; Maria Letizia Barreca; Laura De Luca; Stefania Ferro; Alba Chimirri; zeger debyser; Myriam Witvrouw
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.
Antimicrobial agents and chemotherapy 2008;52(8):2861-9.
2008: Anneleen Hombrouck; Arnout Voet; Barbara Van Remoortel; Christel Desadeleer; Marc De Maeyer; zeger debyser; Myriam Witvrouw
Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137.
Antimicrobial agents and chemotherapy 2008;52(6):2069-78.
2008: Laura De Luca; Maria Letizia Barreca; Stefania Ferro; Nunzio Iraci; Martine Michiels; Frauke Christ; zeger debyser; Myriam Witvrouw; Alba Chimirri
A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.
Bioorganic & medicinal chemistry letters 2008;18(9):2891-5.
2008: Mélanie Dubois; Fabrice Bailly; Gladys Mbemba; Jean-François Mouscadet; zeger debyser; Myriam Witvrouw; Philippe Cotelle
Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents.
Journal of medicinal chemistry 2008;51(8):2575-9.
2008: Xin-yong Liu; Ren-zhang Yan; Yan Wang; Peng Zhan; Erik De Clercq; Christophe Pannecouque; Myriam Witvrouw; Maria Teresa Molina; Salvador Vega
Synthesis and anti-HIV activity evaluation of novel 2,4-disubstituted 7-methyl-1,1,3-trioxo-2,4-dihydro-pyrazolo-[4,5-e][1,2]thiadiazines.
Archiv der Pharmazie 2008;341(4):216-22.
2008: Raveendra Dayam; Laith Q Al-Mawsawi; Zahrah Zawahir; Myriam Witvrouw; zeger debyser; Nouri Neamati
Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors.
Journal of medicinal chemistry 2008;51(5):1136-44.
2007: Laith Q Al-Mawsawi; Raveendra Dayam; Laleh Taheri; Myriam Witvrouw; zeger debyser; Nouri Neamati
Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(23):6472-5.
2007: Claudia Mugnaini; Suvi Rajamaki; Cristina Tintori; Federico Corelli; Silvio Massa; Myriam Witvrouw; zeger debyser; veljko veljkovic; Maurizio Botta
Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies.
Bioorganic & medicinal chemistry letters 2007;17(19):5370-3.
2007: Cristina Tintori; Fabrizio Manetti; Nevena Veljkovic; Vladimir Perovic; Jo Vercammen; Sean Hayes; Silvio Massa; Myriam Witvrouw; zeger debyser; veljko veljkovic; Maurizio Botta
Novel virtual screening protocol based on the combined use of molecular modeling and electron-ion interaction potential techniques to design HIV-1 integrase inhibitors.
Journal of chemical information and modeling 2007;47(4):1536-44.
2007: Stefania Ferro; Maria Letizia Barreca; Laura De Luca; Angela Rao; Anna Maria Monforte; zeger debyser; Myriam Witvrouw; Alba Chimirri
New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors.
Archiv der Pharmazie 2007;340(6):292-8.
2007: Anneleen Hombrouck; Anke Hantson; Barbara Van Remoortel; Martine Michiels; Jo Vercammen; D Rhodes; V Tetz; Yves Engelborghs; Frauke Christ; zeger debyser; Myriam Witvrouw
Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action.
The Journal of antimicrobial chemotherapy 2007;59(6):1084-95.
2007: Anneleen Hombrouck; Jan De Rijck; Jelle Hendrix; Linos Vandekerckhove; Arnout Voet; Marc De Maeyer; Myriam Witvrouw; Yves Engelborghs; Frauke Christ; Rik Gijsbers; zeger debyser
Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.
PLoS pathogens 2007;3(3):e47.
2006: Laith Q Al-Mawsawi; Valery Fikkert; Raveendra Dayam; Myriam Witvrouw; Terrence R Burke; Christoph H Borchers; Nouri Neamati
Discovery of a small-molecule HIV-1 integrase inhibitor-binding site.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(26):10080-5.
2006: Linos Vandekerckhove; Frauke Christ; Bénédicte Van Maele; Jan De Rijck; Rik Gijsbers; Chris Van den Haute; Myriam Witvrouw; zeger debyser
Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus.
Journal of virology 2006;80(4):1886-96.
2005: Maria Letizia Barreca; Stefania Ferro; Angela Rao; Laura De Luca; Maria Zappalà; Anna Maria Monforte; zeger debyser; Myriam Witvrouw; Alba Chimirri
Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.
Journal of medicinal chemistry 2005;48(22):7084-8.
2005: Stéphane Emiliani; Aurélie Mousnier; Katrien Busschots; Marlène Maroun; Bénédicte Van Maele; Denis Tempé; Linos Vandekerckhove; Fanny Moisant; Lilia Ben-Slama; Myriam Witvrouw; Frauke Christ; Jean-Christophe Rain; Catherine Dargemont; zeger debyser; Richard Benarous
Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication.
The Journal of biological chemistry 2005;280(27):25517-23.
2005: Myriam Witvrouw; Valery Fikkert; Anke Hantson; Christophe Pannecouque; Barry R O'Keefe; James McMahon; Leonidas Stamatatos; Erik De Clercq; Anders Bolmstedt
Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A.
Journal of virology 2005;79(12):7777-84.
2005: Anke Hantson; Valery Fikkert; Barbara Van Remoortel; Christophe Pannecouque; Peter Cherepanov; Barry Matthews; George Holan; Erik De Clercq; Anne-Mieke Vandamme; zeger debyser; Myriam Witvrouw
Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology.
Antiviral chemistry & chemotherapy 2005;16(4):253-66.
2004: Valery Fikkert; Anneleen Hombrouck; Barbara Van Remoortel; Marc De Maeyer; Christophe Pannecouque; Erik De Clercq; zeger debyser; Myriam Witvrouw
Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360.
AIDS (London, England) 2004;18(15):2019-28.
2004: Myriam Witvrouw; Bénédicte Van Maele; Jo Vercammen; Anke Hantson; Yves Engelborghs; Erik De Clercq; Christophe Pannecouque; zeger debyser
Novel inhibitors of HIV-1 integration.
Current drug metabolism 2004;5(4):291-304.
2004: Maria Letizia Barreca; Angela Rao; Laura De Luca; Maria Zappalà; Cristina Gurnari; Pietro Monforte; Erik De Clercq; Bénédicte Van Maele; zeger debyser; Myriam Witvrouw; James M Briggs; Alba Chimirri
Efficient 3D database screening for novel HIV-1 IN inhibitors.
Journal of chemical information and computer sciences 2004;44(4):1450-5.
2004: Myriam Witvrouw; Christophe Pannecouque; William Switzer; Thomas M Folks; Erik De Clercq; Walid Heneine
Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: implications for treatment and postexposure prophylaxis.
Antiviral therapy 2004;9(1):57-65.
2003: Myriam Witvrouw; Christophe Pannecouque; Valery Fikkert; Anke Hantson; Barbara Van Remoortel; Marjan Hezareh; Erik De Clercq; Stephen J Brown
Potent and selective inhibition of HIV and SIV by prostratin interacting with viral entry.
Antiviral chemistry & chemotherapy 2003;14(6):321-8.
2003: Valery Fikkert; Bénédicte Van Maele; Jo Vercammen; Anke Hantson; Barbara Van Remoortel; Martine Michiels; Cristina Gurnari; Christophe Pannecouque; Marc De Maeyer; Yves Engelborghs; Erik De Clercq; zeger debyser; Myriam Witvrouw
Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations.
Journal of virology 2003;77(21):11459-70.
2003: Irene M Lagoja; Christophe Pannecouque; Arthur Van Aerschot; Myriam Witvrouw; zeger debyser; Jan Balzarini; Piet Herdewijn; Erik De Clercq
N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action.
Journal of medicinal chemistry 2003;46(8):1546-53.
2002: Valery Fikkert; Peter Cherepanov; Kristel Van Laethem; Anke Hantson; Barbara Van Remoortel; Christophe Pannecouque; Erik De Clercq; zeger debyser; Anne-Mieke Vandamme; Myriam Witvrouw
env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors.
Antimicrobial agents and chemotherapy 2002;46(12):3954-62.
2002: Wim Pluymers; Godwin C G Pais; Bénédicte Van Maele; Christophe Pannecouque; Valery Fikkert; Terrence R Burke; Erik De Clercq; Myriam Witvrouw; Nouri Neamati; zeger debyser
Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives.
Antimicrobial agents and chemotherapy 2002;46(10):3292-7.
2002: Christophe Pannecouque; Wim Pluymers; Bénédicte Van Maele; Victor Tetz; Peter Cherepanov; Erik De Clercq; Myriam Witvrouw; zeger debyser
New class of HIV integrase inhibitors that block viral replication in cell culture.
Current biology : CB 2002;12(14):1169-77.
2002: zeger debyser; Peter Cherepanov; Bénédicte Van Maele; Erik De Clercq; Myriam Witvrouw
In search of authentic inhibitors of HIV-1 integration.
Antiviral chemistry & chemotherapy 2002;13(1):1-15.
2001: Maria Letizia Barreca; Alba Chimirri; Laura De Luca; Anna Maria Monforte; Pietro Monforte; Angela Rao; Maria Zappalà; Jan Balzarini; Erik De Clercq; Christophe Pannecouque; Myriam Witvrouw
Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents.
Bioorganic & medicinal chemistry letters 2001;11(13):1793-6.
2001: Alba Chimirri; Pietro Monforte; Angela Rao; Maria Zappalà; Anna Maria Monforte; G De Sarro; Christophe Pannecouque; Myriam Witvrouw; Jan Balzarini; Erik De Clercq
Synthesis, biological activity, pharmacokinetic properties and molecular modelling studies of novel 1H,3H-oxazolo[3,4-a]benzimidazoles: non-nucleoside HIV-1 reverse transcriptase inhibitors.
Antiviral chemistry & chemotherapy 2001;12(3):169-74.
2001: Kristel Van Laethem; Myriam Witvrouw; Christophe Pannecouque; Barbara Van Remoortel; Jean-Claude Schmit; Robert M Esnouf; JP Kleim; Jan Balzarini; Jan Desmyter; Erik De Clercq; Anne-Mieke Vandamme
Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype.
AIDS (London, England) 2001;15(5):553-61.
2000: Myriam Witvrouw; Valery Fikkert; Wim Pluymers; Barry Matthews; K Mardel; Dominique Schols; J Raff; zeger debyser; Erik De Clercq; George Holan; Christophe Pannecouque
Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle.
Molecular pharmacology 2000;58(5):1100-8.
2000: Wim Pluymers; Nouri Neamati; Christophe Pannecouque; Valery Fikkert; C Marchand; Terrence R Burke; Y Pommier; Dominique Schols; Erik De Clercq; zeger debyser; Myriam Witvrouw
Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters.
Molecular pharmacology 2000;58(3):641-8.
2000: Kristien Van Vaerenbergh; Kristel Van Laethem; J Albert; C A Boucher; Bonaventura Clotet; Marco Floridia; J Gerstoft; B Hejdeman; C Nielsen; Christophe Pannecouque; L Perrin; Maria F Pirillo; Lidia Ruiz; Jean-Claude Schmit; F Schneider; A Schoolmeester; R Schuurman; Hans-Jürgen Stellbrink; Lieven Stuyver; Jan van Lunzen; Barbara Van Remoortel; Eric Van Wijngaerden; STEFANO VELLA; Myriam Witvrouw; S Yerly; Erik De Clercq; J Destmyer; Anne-Mieke Vandamme
Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues.
Antimicrobial agents and chemotherapy 2000;44(8):2109-17.
2000: Kristel Van Laethem; Jean-Claude Schmit; H Pelemans; Jan Balzarini; Myriam Witvrouw; María-Jesús Pérez-Pérez; María-José Camarasa; Robert M Esnouf; Stefano Aquaro; Alessandra Cenci; Carlo Federico Perno; Philippe Hermans; S Sprecher; Lidia Ruiz; Bonaventura Clotet; Eric Van Wijngaerden; Marc Van Ranst; Jan Desmyter; Erik De Clercq; Anne-Mieke Vandamme
Presence of 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",2"-oxath iole-2",2"-dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients.
AIDS research and human retroviruses 2000;16(9):825-33.
2000: Myriam Witvrouw; Christophe Pannecouque; Jan Desmyter; Erik De Clercq; Koen Andries
In vitro evaluation of the effect of temporary removal of HIV drug pressure.
Antiviral research 2000;46(3):215-21.
2000: Kristel Van Laethem; Myriam Witvrouw; Jan Balzarini; Jean-Claude Schmit; S Sprecher; Philippe Hermans; M Leal; Thomas Harrer; Lidia Ruiz; Bonaventura Clotet; Marc Van Ranst; Jan Desmyter; Erik De Clercq; Anne-Mieke Vandamme
Patient HIV-1 strains carrying the multiple nucleoside resistance mutations are cross-resistant to abacavir.
AIDS (London, England) 2000;14(4):469-71.
2000: Myriam Witvrouw; H Weigold; Christophe Pannecouque; Dominique Schols; Erik De Clercq; George Holan
Potent anti-HIV (type 1 and type 2) activity of polyoxometalates: structure-activity relationship and mechanism of action.
Journal of medicinal chemistry 2000;43(5):778-83.
2000: Dirk Daelemans; Dominique Schols; Myriam Witvrouw; Christophe Pannecouque; Sigrid Hatse; Sonia Van Dooren; François Hamy; Thomas Klimkait; Erik De Clercq; Anne-Mieke Vandamme
A second target for the peptoid Tat/transactivation response element inhibitor CGP64222: inhibition of human immunodeficiency virus replication by blocking CXC-chemokine receptor 4-mediated virus entry.
Molecular pharmacology 2000;57(1):116-24.
1999: M E Arranz; JA Díaz; ST Ingate; Myriam Witvrouw; Christophe Pannecouque; Jan Balzarini; Erik De Clercq; S Vega
Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs): a new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 1999;7(12):2811-22.
1999: Kristel Van Laethem; Koen A De Smet; Jean-Claude Schmit; S Sprecher; Philippe Hermans; V De Vroey; R Schuurman; Thomas Harrer; Myriam Witvrouw; Eric Van Wijngaerden; Lieven Stuyver; Marc Van Ranst; Jan Desmyter; Erik De Clercq; Anne-Mieke Vandamme
Phenotypic assays and sequencing are less sensitive than point mutation assays for detection of resistance in mixed HIV-1 genotypic populations.
Journal of acquired immune deficiency syndromes (1999) 1999;22(2):107-18.
1999: Gary J Bridger; Renato T Skerlj; S Padmanabhan; S A Martellucci; Geoffrey Henson; Sofie Struyf; Myriam Witvrouw; Dominique Schols; Erik De Clercq
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4.
Journal of medicinal chemistry 1999;42(19):3971-81.
1999: Jan Van Gelder; Myriam Witvrouw; Christophe Pannecouque; Geoffrey Henson; Gary J Bridger; Lieve Naesens; Erik De Clercq; Pieter Annaert; Manijeh Shafiee; Guy Van den Mooter; Renaat Kinget; Patrick Augustijns
Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA.
International journal of pharmaceutics 1999;186(2):127-36.
1999: Myriam Witvrouw; C Pannecouque; Kristel Van Laethem; Jan Desmyter; Erik De Clercq; Anne-Mieke Vandamme
Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV.
AIDS (London, England) 1999;13(12):1477-83.
1999: Alba Chimirri; Silvana Grasso; Pietro Monforte; Angela Rao; Maria Zappalà; Anna Maria Monforte; Christophe Pannecouque; Myriam Witvrouw; Jan Balzarini; Erik De Clercq
Synthesis and biological activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles: non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.
Antiviral chemistry & chemotherapy 1999;10(4):211-7.
1999: Myriam Witvrouw; Christophe Pannecouque; Erik De Clercq; E Fernández-Alvarez; JL Marco
Inhibition of human immunodeficiency virus type (HIV-1) replication by some diversely functionalized spirocyclopropyl derivatives.
Archiv der Pharmazie 1999;332(5):163-6.
1999: Anne-Mieke Vandamme; Kristel Van Laethem; Jean-Claude Schmit; Eric Van Wijngaerden; M Reynders; zeger debyser; Myriam Witvrouw; Marc Van Ranst; Erik De Clercq; Jan Desmyter
Long-term stability of human immunodeficiency virus viral load and infectivity in whole blood.
European journal of clinical investigation 1999;29(5):445-52.
1998: Jean-Claude Schmit; Kristel Van Laethem; Lidia Ruiz; Philippe Hermans; S Sprecher; Anders Sönnerborg; M Leal; Thomas Harrer; Bonaventura Clotet; Vic Arendt; E Lissen; Myriam Witvrouw; Jan Desmyter; Erik De Clercq; Anne-Mieke Vandamme
Multiple dideoxynucleoside analogue-resistant (MddNR) HIV-1 strains isolated from patients from different European countries.
AIDS (London, England) 1998;12(15):2007-15.
1998: E Arranz; JA Díaz; ST Ingate; Myriam Witvrouw; Christophe Pannecouque; Jan Balzarini; Erik De Clercq; S Vega
Novel 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine derivatives as non-nucleoside reverse transcriptase inhibitors that inhibit human immunodeficiency virus type 1 replication.
Journal of medicinal chemistry 1998;41(21):4109-17.
1998: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Pietro Monforte; Angela Rao; Maria Zappalà; G Bruno; F Nicolò; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq
Synthesis, structure and in vitro anti-human immunodeficiency virus activity of novel 3-methyl-1H,3H-thiazolo[3,4-a]benzimidazoles.
Antiviral chemistry & chemotherapy 1998;9(5):431-8.
1998: Myriam Witvrouw; Dirk Daelemans; Christophe Pannecouque; Johan Neyts; Graciela Andrei; Robert Snoeck; Anne-Mieke Vandamme; Jan Balzarini; Jan Desmyter; M Baba; Erik De Clercq
Broad-spectrum antiviral activity and mechanism of antiviral action of the fluoroquinolone derivative K-12.
Antiviral chemistry & chemotherapy 1998;9(5):403-11.
1998: Myriam Witvrouw; M E Arranz; Christophe Pannecouque; Ruben Declercq; H Jonckheere; Jean-Claude Schmit; Anne-Mieke Vandamme; J A Diaz; ST Ingate; Jan Desmyter; Robert M Esnouf; Luc Van Meervelt; S Vega; Jan Balzarini; Erik De Clercq
1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activity.
Antimicrobial agents and chemotherapy 1998;42(3):618-23.
1998: H Jonckheere; Myriam Witvrouw; Erik De Clercq; Jozef Anne
Lamivudine resistance of HIV type 1 does not delay development of resistance to nonnucleoside HIV type 1-specific reverse transcriptase inhibitors as compared with wild-type HIV type 1.
AIDS research and human retroviruses 1998;14(3):249-53.
1998: José A Esté; C Cabrera; Dominique Schols; Peter Cherepanov; A Gutierrez; Myriam Witvrouw; Christophe Pannecouque; zeger debyser; RF Rando; B Clotet; Jan Desmyter; E De Clercq
Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).
Molecular pharmacology 1998;53(2):340-5.
1997: Dirk Daelemans; José A Esté; Myriam Witvrouw; Christophe Pannecouque; H Jonckheere; Stefano Aquaro; Carlo Federico Perno; Erik De Clercq; Anne-Mieke Vandamme
S-adenosylhomocysteine hydrolase inhibitors interfere with the replication of human immunodeficiency virus type 1 through inhibition of the LTR transactivation.
Molecular pharmacology 1997;52(6):1157-63.
1997: Myriam Witvrouw; Erik De Clercq
Sulfated polysaccharides extracted from sea algae as potential antiviral drugs.
General pharmacology 1997;29(4):497-511.
1997: Jan Balzarini; J Kruining; O Wedgwood; Christophe Pannecouque; Stefano Aquaro; Carlo Federico Perno; Lieve Naesens; Myriam Witvrouw; Rudolf Heijtink; Erik De Clercq; Christopher McGuigan
Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.
FEBS letters 1997;410(2-3):324-8.
1997: Jan Balzarini; T Vahlenkamp; Herman Egberink; K Hartmann; Myriam Witvrouw; Christophe Pannecouque; P Casara; J F Navé; Erik De Clercq
Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI mice.
Antimicrobial agents and chemotherapy 1997;41(3):611-6.
1997: Myriam Witvrouw; Jan Balzarini; Christophe Pannecouque; S Jhaumeer-Laulloo; José A Esté; Dominique Schols; Peter Cherepanov; Jean-Claude Schmit; zeger debyser; Anne-Mieke Vandamme; Jan Desmyter; S R Ramadas; Erik De Clercq
SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus.
Antimicrobial agents and chemotherapy 1997;41(2):262-8.
1997: Myriam Witvrouw; Jean-Claude Schmit; Barbara Van Remoortel; Dirk Daelemans; José A Esté; Anne-Mieke Vandamme; Jan Desmyter; Erik De Clercq
Cell type-dependent effect of sodium valproate on human immunodeficiency virus type 1 replication in vitro.
AIDS research and human retroviruses 1997;13(2):187-92.
1996: Jean-Claude Schmit; J Cogniaux; P Hermans; Christophe Van Vaeck; S Sprecher; B Van Remoortel; Myriam Witvrouw; Jan Balzarini; Jan Desmyter; E De Clercq; Anne-Mieke Vandamme
Multiple drug resistance to nucleoside analogues and nonnucleoside reverse transcriptase inhibitors in an efficiently replicating human immunodeficiency virus type 1 patient strain.
The Journal of infectious diseases 1996;174(5):962-8.
1996: Anne-Mieke Vandamme; Jean-Claude Schmit; Sonia Van Dooren; Kristel Van Laethem; E Gobbers; W Kok; Patrick Goubau; Myriam Witvrouw; W Peetermans; E De Clercq; Jan Desmyter
Quantification of HIV-1 RNA in plasma: comparable results with the NASBA HIV-1 RNA QT and the AMPLICOR HIV monitor test.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1996;13(2):127-39.
1996: Jan Balzarini; H Pelemans; Stefano Aquaro; Carlo Federico Perno; Myriam Witvrouw; Dominique Schols; E De Clercq; Anna Karlsson
Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication.
Molecular pharmacology 1996;50(2):394-401.
1996: M Vandevelde; Myriam Witvrouw; Jean-Claude Schmit; S Sprecher; E De Clercq; J P Tassignon
ADA, a potential anti-HIV drug.
AIDS research and human retroviruses 1996;12(7):567-8.
1996: Alain Leydet; H El Hachemi; B Boyer; G Lamaty; JP Roque; Dominique Schols; Robert Snoeck; Graciela Andrei; S Ikeda; Johan Neyts; D Reymen; J Este; Myriam Witvrouw; E De Clercq
Polyanion inhibitors of human immunodeficiency virus and other viruses. Part 2. Polymerized anionic surfactants derived from amino acids and dipeptides.
Journal of medicinal chemistry 1996;39(8):1626-34.
1996: José A Esté; K De Vreese; Myriam Witvrouw; Jean-Claude Schmit; Anne-Mieke Vandamme; Jozef Anne; Jan Desmyter; Geoffrey Henson; Gary J Bridger; E De Clercq
Antiviral activity of the bicyclam derivative JM3100 against drug-resistant strains of human immunodeficiency virus type 1.
Antiviral research 1996;29(2-3):297-307.
1996: Jan Balzarini; Stefano Aquaro; Carlo Federico Perno; Myriam Witvrouw; Antonín Holý; E De Clercq
Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems.
Biochemical and biophysical research communications 1996;219(2):337-41.
1996: Gary J Bridger; Renato T Skerlj; S Padmanabhan; S A Martellucci; Geoffrey Henson; M J Abrams; H C Joao; Myriam Witvrouw; K De Vreese; Rudi Pauwels; E De Clercq
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit human immunodeficiency virus replication. 2. Effect of heteroaromatic linkers on the activity of bicyclams.
Journal of medicinal chemistry 1996;39(1):109-19.
1995: José A Esté; Myriam Witvrouw; J Tu; Jan Desmyter; E De Clercq; Anne-Mieke Vandamme
Inhibition of HIV type 1 Tat-mediated trans-activation by oncostatin M in HLtat cells.
AIDS research and human retroviruses 1995;11(11):1355-8.
1995: Johan Neyts; D Reymen; Didier Letourneur; J Jozefonvicz; Dominique Schols; J Este; Graciela Andrei; P McKenna; Myriam Witvrouw; S Ikeda
Differential antiviral activity of derivatized dextrans.
Biochemical pharmacology 1995;50(6):743-51.
1995: Halldor Thormar; Jan Balzarini; zeger debyser; Myriam Witvrouw; Jan Desmyter; E De Clercq
Inhibition of visna virus replication and cytopathic effect in sheep choroid plexus cell cultures by selected anti-HIV agents.
Antiviral research 1995;27(1-2):49-57.
1994: Elsa B Damonte; Johan Neyts; Carlos A Pujol; R Snoeck; Graciela Andrei; S Ikeda; Myriam Witvrouw; D Reymen; H Haines; María C Matulewicz
Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata.
Biochemical pharmacology 1994;47(12):2187-92.
1994: E De Clercq; N Yamamoto; Rudi Pauwels; Jan Balzarini; Myriam Witvrouw; K De Vreese; zeger debyser; B Rosenwirth; Peter Peichl; R Datema
Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100.
Antimicrobial agents and chemotherapy 1994;38(4):668-74.
1992: Myriam Witvrouw; Rudi Pauwels; Anne-Mieke Vandamme; Dominique Schols; D Reymen; N Yamamoto; Jan Desmyter; E De Clercq
Cell type-specific anti-human immunodeficiency virus type 1 activity of the transactivation inhibitor Ro5-3335.
Antimicrobial agents and chemotherapy 1992;36(12):2628-33.
1990: Myriam Witvrouw; M Baba; Jan Balzarini; Rudi Pauwels; E De Clercq
Establishment of a bioassay to determine serum levels of dextran sulfate and pentosan polysulfate, two potent inhibitors of human immunodeficiency virus.
Journal of acquired immune deficiency syndromes 1990;3(4):343-7.