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Stephen Wiviott

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Owen Mogabgab; Marc S Sabatine; Tracy Y Wang; Stephen D Wiviott; Elliot M Antman; Christopher P Cannon; JoAnne M Foody; Shuang Li; Robert P Giugliano
Relation between time of symptom onset of ST-segment elevation myocardial infarction and patient baseline characteristics: from the National Cardiovascular Data Registry.
Philippe Gabriel STEG; Stephen D Wiviott; Christoph Bode; Karen Fanouillere; Christophe Gaudin; Shamir R Mehta; Angele Moryusef; Charles V Pollack; Marc S Sabatine
Design and rationale of the treatment of acute coronary syndromes with otamixaban trial: a double-blind triple-dummy 2-stage randomized trial comparing otamixaban to unfractionated heparin and eptifibatide in non-ST-segment elevation acute coronary syndromes with a planned early invasive strategy.
Owen Mogabgab; Satishkumar Mohanavelu; Marc S Sabatine; Stephen D Wiviott; Elliott M Antman; Christopher P Cannon; Robert P Giugliano; Eugene Braunwald
Circadian variation in patient characteristics and outcomes in ST-segment elevation myocardial infarction.

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2013: Owen Mogabgab; Marc S Sabatine; Tracy Y Wang; Stephen D Wiviott; Elliot M Antman; Christopher P Cannon; JoAnne M Foody; Shuang Li; Robert P Giugliano
Relation between time of symptom onset of ST-segment elevation myocardial infarction and patient baseline characteristics: from the National Cardiovascular Data Registry.
Clinical cardiology 2013;36(4):222-7.
2012: Philippe Gabriel STEG; Stephen D Wiviott; Christoph Bode; Karen Fanouillere; Christophe Gaudin; Shamir R Mehta; Angele Moryusef; Charles V Pollack; Marc S Sabatine
Design and rationale of the treatment of acute coronary syndromes with otamixaban trial: a double-blind triple-dummy 2-stage randomized trial comparing otamixaban to unfractionated heparin and eptifibatide in non-ST-segment elevation acute coronary syndromes with a planned early invasive strategy.
American heart journal 2012;164(6):817-24.e13.
2012: Owen Mogabgab; Satishkumar Mohanavelu; Marc S Sabatine; Stephen D Wiviott; Elliott M Antman; Christopher P Cannon; Robert P Giugliano; Eugene Braunwald
Circadian variation in patient characteristics and outcomes in ST-segment elevation myocardial infarction.
Chronobiology international 2012;29(10):1390-6.
2012: Ravi V Shah; Tracy Y Wang; Stephen D Wiviott; Monique Anderson; DaJuanicia Holmes; Michael C Kontos; Benjamin M Scirica
Risk of heart failure complication during hospitalization for acute myocardial infarction in a contemporary population: insights from the National Cardiovascular Data ACTION Registry.
Circulation. Heart failure 2012;5(6):693-702.
2012: John P Vavalle; Tracy Y Wang; Stephen D Wiviott; Anita Y Chen; P Michael Ho; Renato D Lopes; L Kristin Newby; Eric D Peterson; Matthew T Roe; Bimal R Shah; Christopher B Granger
Hospital length of stay in patients with non-ST-segment elevation myocardial infarction.
The American journal of medicine 2012;125(11):1085-94.
2012: Udo Hoffmann; Shant Kalanjian; Hang Lee; Issam Mikati; Michael E Mullins; John T Nagurney; W Frank Peacock; J Hector Pope; David A Schoenfeld; Quynh A Truong; James E Udelson; Scott G Weiner; Charles S White; Stephen D Wiviott; Pamela K Woodard; Pearl Zakroysky; Eric T Chou; Jerome L Fleg; G Scott Gazelle; Alexander Goehler; Thomas H Hauser; Douglas Hayden
Coronary CT angiography versus standard evaluation in acute chest pain.
The New England journal of medicine 2012;367(4):299-308.
2012: Michelle L O'Donoghue; Fang Ren; Uwe Zeymer; Rafal Ziecina; Dominick J Angiolillo; Philip E Aylward; Deepak L Bhatt; Marcus D Flather; Shaun G Goodman; Shinya Goto; Hiroyuki Kobayashi; Gilles Montalescot; Stephen D Wiviott
Atopaxar and its effects on markers of platelet activation and inflammation: results from the LANCELOT CAD program.
Journal of thrombosis and thrombolysis 2012;34(1):36-43.
2012: Thomas M Maddox; Fredrick A Masoudi; S Andrew Peng; P Michael Ho; Shuang Li; Thomas T Tsai; Tracy Y Wang; Stephen D Wiviott; John S Rumsfeld
Clopidogrel use and hospital quality in medically managed patients with non-ST-segment-elevation myocardial infarction.
Circulation. Cardiovascular quality and outcomes 2012;5(4):523-31.
2012: David A Morrow; Sabina A Murphy; José Carlos Nicolau; A J Oude Ophuis; Ernesto Paolasso; Benjamin M Scirica; Jindrich Spinar; John Strony; Pierre Theroux; Stephen D Wiviott; Sebastian F Ameriso; Marc P Bonaca; Eugene Braunwald; Anthony J Dalby; Mary Polly Fish; Keith A A Fox; Leslie J Lipka; Xuan Liu
Vorapaxar in the secondary prevention of atherothrombotic events.
The New England journal of medicine 2012;366(15):1404-13.
2012: Christian T Ruff; Fredrik Schersten; Ricardo Seabro-Gomes; Stephen D Wiviott; Elliott M Antman; Luciano Baracioli; Eugene Braunwald; Robert P Giugliano; Herbertus Heuer; Chaim Lotan; Bela Merkely; Sabina A Murphy
Safety and efficacy of prasugrel compared with clopidogrel in different regions of the world.
International journal of cardiology 2012;155(3):424-9.
2012: Sumeet Subherwal; Jeffrey B Washam; Stephen D Wiviott; Karen P Alexander; Richard G Bach; Deepak L Bhatt; Anita Y Chen; Brian F Gage; Renato D Lopes; Eric D Peterson; Matthew T Roe; Tracy Y Wang
Admission international normalized ratio levels, early treatment strategies, and major bleeding risk among non-ST-segment-elevation myocardial infarction patients on home warfarin therapy: insights from the National Cardiovascular Data Registry.
Circulation 2012;125(11):1414-23.
2012: Marc P Bonaca; Eugene Braunwald; Sabina A Murphy; Christian T Ruff; Stephen D Wiviott; Elliott M Antman; David A Morrow
American College of Cardiology/American Heart Association/European Society of Cardiology/World Heart Federation universal definition of myocardial infarction classification system and the risk of cardiovascular death: observations from the TRITON-TIMI 38 trial (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis in Myocardial Infarction 38).
Circulation 2012;125(4):577-83.
2012: Caroline S Fox; Paul Muntner; Matthew T Roe; Karen P Alexander; Anita Y Chen; Stephen D Wiviott
Short-term outcomes of acute myocardial infarction in patients with acute kidney injury: a report from the national cardiovascular data registry.
Circulation 2012;125(3):497-504.
2012: Chee Tang Chin; James A deLemos; Michael C Kontos; Shuang Li; Eric D Peterson; Tracy Y Wang; Stephen D Wiviott; Matthew T Roe
Comparison of the prognostic value of peak creatine kinase-MB and troponin levels among patients with acute myocardial infarction: a report from the Acute Coronary Treatment and Intervention Outcomes Network Registry-get with the guidelines.
Clinical cardiology 2012;35(7):424-9.
2011: Stephen D Wiviott; Willibald Hochholzer
On-clopidogrel platelet reactivity: a target in sight?
Journal of the American College of Cardiology 2011;58(19):1955-7.
2011: Chiara Melloni; Eric D Peterson; Matthew T Roe; Tracy Y Wang; Stephen D Wiviott; Anita Y Chen; P Michael Ho; Karen P Alexander
Use of early clopidogrel by reperfusion strategy among patients presenting with ST-segment elevation myocardial infarction.
Circulation. Cardiovascular quality and outcomes 2011;4(6):603-9.
2011: Stephen D Wiviott; Elliott M Antman; Nihar Desai; Sabina A Murphy; Giuseppe Musumeci; Michael Ragosta; Eugene Braunwald
Efficacy and safety of intensive antiplatelet therapy with prasugrel from TRITON-TIMI 38 in a core clinical cohort defined by worldwide regulatory agencies.
The American journal of cardiology 2011;108(7):905-11.
2011: Elias B Hanna; Matthew T Roe; Anita Y Chen; Caroline S Fox; Stephen D Wiviott; Jorge F Saucedo
Characteristics and in-hospital outcomes of patients with non-ST-segment elevation myocardial infarction and chronic kidney disease undergoing percutaneous coronary intervention.
JACC. Cardiovascular interventions 2011;4(9):1002-8.
2011: Willibald Hochholzer; Adnan Kastrati; Jessica L Mega; Tanja Morath; Franz-Josef Neumann; Michelle L O'Donoghue; Marc S Sabatine; Albert Schömig; Christian Stratz; Dietmar Trenk; Christian M Valina; Stephen D Wiviott; Isabell Bernlochner; Charles F Contant; Jianping Guo; Dirk Sibbing
Impact of smoking on antiplatelet effect of clopidogrel and prasugrel after loading dose and on maintenance therapy.
American heart journal 2011;162(3):518-26.e5.
2011: Stephen D Wiviott
ILLUMINATE sheds more light.
Circulation 2011;124(5):536-7.
2011: Robin Mathews; Eric D Peterson; Matthew T Roe; Jorge F Saucedo; Elliott M Antman; Seth W Glickman; Alice K Jacobs; Shuang Li; Stephen D Wiviott; Tracy Y Wang
Use of emergency medical service transport among patients with ST-segment-elevation myocardial infarction: findings from the National Cardiovascular Data Registry Acute Coronary Treatment Intervention Outcomes Network Registry-Get With The Guidelines.
Circulation 2011;124(2):154-63.
2011: Roxana Mehran; Venu Menon; Eugenia Nikolsky; E Magnus Ohman; Sunil V Rao; Joseph F Sabik; Victor L Serebruany; Philippe Gabriel STEG; David Taggart; Marco Valgimigli; Pascal Vranckx; Deepak L Bhatt; Adriano Caixeta; Donald E Cutlip; John Eikelboom; C Michael Gibson; Sanjay Kaul; Mitchell W Krucoff; Stephen D Wiviott; Harvey White
Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium.
Circulation 2011;123(23):2736-47.
2011: Willibald Hochholzer; Gilles Montalescot; Stephen D Wiviott; Elliott M Antman; Charles F Contant; Anthony J Dalby; Robert P Giugliano; Jianping Guo; Eugene Braunwald
Predictors of bleeding and time dependence of association of bleeding with mortality: insights from the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel--Thrombolysis in Myocardial Infarction 38 (TRITON-TIMI 38).
Circulation 2011;123(23):2681-9.
2011: Sean R Wilson; Marc S Sabatine; Stephen D Wiviott; Kausik K Ray; James A de Lemos; Shanggen Zhou; Nader Rifai; Christopher P Cannon; David A Morrow
Assessment of adiponectin and the risk of recurrent cardiovascular events in patients presenting with an acute coronary syndrome: observations from the Pravastatin Or atorVastatin Evaluation and Infection Trial-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22).
American heart journal 2011;161(6):1147-55.e1.
2011: Farhad Abtahian; Benjamin Olenchock; Fang-Shu Ou; Michael C Kontos; Jorge F Saucedo; Benjamin M Scirica; Nihar Desai; Eric Peterson; Matthew Roe; Christopher P Cannon; Stephen D Wiviott
Effect of prior stroke on the use of evidence-based therapies and in-hospital outcomes in patients with myocardial infarction (from the NCDR ACTION GWTG registry).
The American journal of cardiology 2011;107(10):1441-6.
2011: Michelle L O'Donoghue; Stephen D Wiviott; Uwe Zeymer; Rafal Ziecina; Dominick J Angiolillo; Philip E Aylward; Deepak L Bhatt; Charles F Contant; Dariusz Dudek; Desmond J Fitzgerald; Marcus D Flather; Shaun G Goodman; Shinya Goto; Victor Guetta; Gilles Montalescot
Safety and tolerability of atopaxar in the treatment of patients with acute coronary syndromes: the lessons from antagonizing the cellular effects of Thrombin–Acute Coronary Syndromes Trial.
Circulation 2011;123(17):1843-53.
2011: Stephen D Wiviott; Dominick J Angiolillo; Philip Aylward; Deepak L Bhatt; Charles F Contant; Fernando Cura; Dariusz Dudek; Desmond J Fitzgerald; Marcus D Flather; Shinya Goto; Victor Guetta; Michelle L O'Donoghue
Randomized trial of atopaxar in the treatment of patients with coronary artery disease: the lessons from antagonizing the cellular effect of Thrombin–Coronary Artery Disease Trial.
Circulation 2011;123(17):1854-63.
2011: Creighton W Don; Matthew T Roe; Shuang Li; Elizabeth Fraulo; Eugene Pomerantsev; Igor Palacios; Stephen D Wiviott
Temporal trends and practice variations in clopidogrel loading doses in patients with non-ST-segment elevation myocardial infarction, from the National Cardiovascular Data Registry.
American heart journal 2011;161(4):689-97.
2011: Kathryn A Britton; Vikas Aggarwal; Anita Y Chen; Karen P Alexander; Ezra A Amsterdam; Elizabeth Fraulo; Paul Muntner; Laine Thomas; Darren K McGuire; Stephen D Wiviott; Matthew T Roe; Ulrich Schubart; Caroline S Fox
No association between hemoglobin A1c and in-hospital mortality in patients with diabetes and acute myocardial infarction.
American heart journal 2011;161(4):657-663.e1.
2011: Nihar R Desai; Joshua Beckman; Stephen D Wiviott
When stable becomes unstable: the perils of impersonal medicine.
Circulation 2011;123(3):335-41.
2010: Daniel E Forman; Anita Y Chen; Stephen D Wiviott; Tracy Y Wang; David J Magid; Karen P Alexander
Comparison of outcomes in patients aged <75, 75 to 84, and ≥ 85 years with ST-elevation myocardial infarction (from the ACTION Registry-GWTG).
The American journal of cardiology 2010;106(10):1382-8.
2010: Mitul B Kadakia; Nihar R Desai; Karen P Alexander; Anita Y Chen; JoAnne M Foody; Christopher P Cannon; Stephen D Wiviott; Benjamin M Scirica
Use of anticoagulant agents and risk of bleeding among patients admitted with myocardial infarction: a report from the NCDR ACTION Registry--GWTG (National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry--Get With the Guidelines).
JACC. Cardiovascular interventions 2010;3(11):1166-77.
2010: Jessica L Mega; Tabassome Simon; Jean-Philippe Collet; Jeffrey L Anderson; Elliott M Antman; Kevin Bliden; Christopher P Cannon; Nicolas Danchin; Betti Giusti; Paul A Gurbel; Benjamin D Horne; Jean-Sebastian Hulot; Adnan Kastrati; Gilles Montalescot; Franz-Josef Neumann; Lei Shen; Dirk Sibbing; P Gabriel Steg; Dietmar Trenk; Stephen D Wiviott; Marc S Sabatine
Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis.
JAMA : the journal of the American Medical Association 2010;304(16):1821-30.
2010: Jessica L Mega; Sandra L Close; Stephen D Wiviott; Lei Shen; Joseph R Walker; Tabassome Simon; Elliott M Antman; Eugene Braunwald; Marc S Sabatine
Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis.
Lancet 2010;376(9749):1312-9.
2010: Yuri B Pride; Patricia Tung; Satishkumar Mohanavelu; Cafer Zorkun; Stephen D Wiviott; Elliott M Antman; Robert P Giugliano; Eugene Braunwald; C Michael Gibson
Angiographic and clinical outcomes among patients with acute coronary syndromes presenting with isolated anterior ST-segment depression: a TRITON-TIMI 38 (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis In Myocardial Infarction 38) substudy.
JACC. Cardiovascular interventions 2010;3(8):806-11.
2010: Stephen D Wiviott; Elliott M Antman; Eugene Braunwald
Prasugrel.
Circulation 2010;122(4):394-403.
2010: James R Harkness; Marc S Sabatine; Eugene Braunwald; David A Morrow; Sarah Sloan; Stephen D Wiviott; Robert P Giugliano; Elliott M Antman; Christopher P Cannon; Benjamin M Scirica
Extent of ST-segment resolution after fibrinolysis adds improved risk stratification to clinical risk score for ST-segment elevation myocardial infarction.
American heart journal 2010;159(1):55-62.
2009: Sabina A Murphy; Christopher P Cannon; Stephen D Wiviott; Carolyn H McCabe; Eugene Braunwald
Reduction in recurrent cardiovascular events with intensive lipid-lowering statin therapy compared with moderate lipid-lowering statin therapy after acute coronary syndromes from the PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) trial.
Journal of the American College of Cardiology 2009;54(25):2358-62.
2009: Michelle L O'Donoghue; Eugene Braunwald; Elliott M Antman; Sabina A Murphy; Eric R Bates; Yoseph Rozenman; Alan D Michelson; Raymond W Hautvast; Peter N Ver Lee; Sandra L Close; Lei Shen; Jessica L Mega; Marc S Sabatine; Stephen D Wiviott
Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials.
Lancet 2009;374(9694):989-97.
2009: Michelle O'Donoghue; Elliott M Antman; Eugene Braunwald; Sabina A Murphy; Philippe Gabriel STEG; Ariel Finkelstein; William F Penny; Viliam Fridrich; Carolyn H McCabe; Marc S Sabatine; Stephen D Wiviott
The efficacy and safety of prasugrel with and without a glycoprotein IIb/IIIa inhibitor in patients with acute coronary syndromes undergoing percutaneous intervention: a TRITON-TIMI 38 (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis In Myocardial Infarction 38) analysis.
Journal of the American College of Cardiology 2009;54(8):678-85.
2009: Rebecca E Wrishko; C Steven Ernest; David S Small; Ying G Li; Govinda J Weerakkody; Jeffrey R Riesmeyer; William L Macias; Shashank Rohatagi; Daniel Salazar; Elliott M Antman; Stephen D Wiviott; Eugene Braunwald; Lan Ni
Population pharmacokinetic analyses to evaluate the influence of intrinsic and extrinsic factors on exposure of prasugrel active metabolite in TRITON-TIMI 38.
Journal of clinical pharmacology 2009;49(8):984-98.
2009: Roberto R Giraldez; Stephen D Wiviott; José Carlos Nicolau; Satishkumar Mohanavelu; David A Morrow; Elliott M Antman; Robert P Giugliano
Streptokinase and enoxaparin as an alternative to fibrin-specific lytic-based regimens: an ExTRACT-TIMI 25 analysis.
Drugs 2009;69(11):1433-43.
2009: Stephen D Wiviott; Satishkumar Mohanavelu; Joel S Raichlen; Valerie A Cain; Steven E Nissen; Peter Libby
Safety and efficacy of achieving very low low-density lipoprotein cholesterol levels with rosuvastatin 40 mg daily (from the ASTEROID Study).
The American journal of cardiology 2009;104(1):29-35.
2009: Alan D Michelson; Andrew L Frelinger; Eugene Braunwald; William E Downey; Dominick J Angiolillo; Nicholas P Xenopoulos; Joseph A Jakubowski; Youfu Li; Sabina A Murphy; Jie Qin; Carolyn H McCabe; Elliott M Antman; Stephen D Wiviott
Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial.
European heart journal 2009;30(14):1753-63.
2009: David A Morrow; Stephen D Wiviott; Harvey D White; Jose C Nicolau; Ezio Bramucci; Sabina A Murphy; Marc P Bonaca; Christian T Ruff; Benjamin M Scirica; Carolyn H McCabe; Elliott M Antman; Eugene Braunwald
Effect of the novel thienopyridine prasugrel compared with clopidogrel on spontaneous and procedural myocardial infarction in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel-Thrombolysis in Myocardial Infarction 38: an application of the classification system from the universal definition of myocardial infarction.
Circulation 2009;119(21):2758-64.
2009: Jessica L Mega; Sandra L Close; Stephen D Wiviott; Lei Shen; Richard D Hockett; John T Brandt; Joseph R Walker; Elliott M Antman; William L Macias; Eugene Braunwald; Marc S Sabatine
Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes.
Circulation 2009;119(19):2553-60.
2009: Patricia Tung; Stephen D Wiviott; Christopher P Cannon; Sabina A Murphy; Carolyn H McCabe; C Michael Gibson
Seasonal variation in lipids in patients following acute coronary syndrome on fixed doses of Pravastatin (40 mg) or Atorvastatin (80 mg) (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22 [PROVE IT-TIMI 22] Study).
The American journal of cardiology 2009;103(8):1056-60.
2009: Quynh A Truong; Christopher P Cannon; Neil A Zakai; Ian S Rogers; Robert P Giugliano; Stephen D Wiviott; Carolyn H McCabe; David A Morrow; Eugene Braunwald
Thrombolysis in Myocardial Infarction (TIMI) Risk Index predicts long-term mortality and heart failure in patients with ST-elevation myocardial infarction in the TIMI 2 clinical trial.
American heart journal 2009;157(4):673-9.e1.
2009: Gilles Montalescot; Stephen D Wiviott; Eugene Braunwald; Sabina A Murphy; C Michael Gibson; Carolyn H McCabe; Elliott M Antman
Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial.
Lancet 2009;373(9665):723-31.
2009: Jessica L Mega; Sandra L Close; Stephen D Wiviott; Lei Shen; Richard D Hockett; John T Brandt; Joseph R Walker; Elliott M Antman; William Macias; Eugene Braunwald; Marc S Sabatine
Cytochrome p-450 polymorphisms and response to clopidogrel.
The New England journal of medicine 2009;360(4):354-62.
2009: Deborah B Diercks; Michael C Kontos; Anita Y Chen; Charles V Pollack; Stephen D Wiviott; John S Rumsfeld; David J Magid; W Brian Gibler; Christopher P Cannon; eric peterson; Matthew T Roe
Utilization and impact of pre-hospital electrocardiograms for patients with acute ST-segment elevation myocardial infarction: data from the NCDR (National Cardiovascular Data Registry) ACTION (Acute Coronary Treatment and Intervention Outcomes Network) Registry.
Journal of the American College of Cardiology 2009;53(2):161-6.
2008: Stephen D Wiviott
Intensity of antiplatelet therapy in patients with acute coronary syndromes and percutaneous coronary intervention: the promise of prasugrel?
Cardiology clinics 2008;26(4):629-37.
2008: Stephen D Wiviott; Eugene Braunwald; Dominick J Angiolillo; Simha Meisel; Anthony J Dalby; Freek W A Verheugt; Shaun G Goodman; Ramon Corbalan; Drew A Purdy; Sabina A Murphy; Carolyn H McCabe; Elliott M Antman
Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in Myocardial Infarction 38.
Circulation 2008;118(16):1626-36.
2008: Sabina A Murphy; Elliott M Antman; Stephen D Wiviott; Govinda Weerakkody; Giorgio Morocutti; Kurt Huber; Jose Lopez-Sendon; Carolyn H McCabe; Eugene Braunwald
Reduction in recurrent cardiovascular events with prasugrel compared with clopidogrel in patients with acute coronary syndromes from the TRITON-TIMI 38 trial.
European heart journal 2008;29(20):2473-9.
2008: Benjamin A Olenchock; Stephen D Wiviott; Sabina A Murphy; Christopher P Cannon; Nader Rifai; Eugene Braunwald; David A Morrow
Lack of association between soluble CD40L and risk in a large cohort of patients with acute coronary syndrome in OPUS TIMI-16.
Journal of thrombosis and thrombolysis 2008;26(2):79-84.
2008: Emmanouil Brilakis; James A de Lemos; Christopher P Cannon; Stephen D Wiviott; Sabina A Murphy; David A Morrow; Marc S Sabatine; Subhash Banerjee; Michael A Blazing; Robert M Califf; Eugene Braunwald
Outcomes of patients with acute coronary syndrome and previous coronary artery bypass grafting (from the Pravastatin or Atorvastatin Evaluation and Infection Therapy [PROVE IT-TIMI 22] and the Aggrastat to Zocor [A to Z] trials).
The American journal of cardiology 2008;102(5):552-8.
2008: Elliott M Antman; Stephen D Wiviott; Sabina A Murphy; Juri Voitk; Yonathan Hasin; Petr Widimsky; Harish Chandna; William Macias; Carolyn H McCabe; Eugene Braunwald
Early and late benefits of prasugrel in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a TRITON-TIMI 38 (TRial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet InhibitioN with Prasugrel-Thrombolysis In Myocardial Infarction) analysis.
Journal of the American College of Cardiology 2008;51(21):2028-33.
2008: Stephen D Wiviott; Eugene Braunwald; Sabina A Murphy; Elliott M Antman
A perspective on the efficacy and safety of intensive antiplatelet therapy in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-thrombolysis in myocardial infarction 38.
The American journal of cardiology 2008;101(9):1367-70.
2008: Stephen D Wiviott; Eugene Braunwald; Carolyn H McCabe; Ivan Horvath; Mátyás Keltai; Jean-Paul R Herrman; Frans Van de Werf; William E Downey; Benjamin M Scirica; Sabina A Murphy; Elliott M Antman
Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: a subanalysis of a randomised trial.
Lancet 2008;371(9621):1353-63.
2007: Stephen D Wiviott; Dietmar Trenk; Andrew L Frelinger; Michelle O'Donoghue; Franz-Josef Neumann; Alan D Michelson; Dominick J Angiolillo; Hanoch Hod; Gilles Montalescot; Debra L Miller; Joseph A Jakubowski; Richard Cairns; Sabina A Murphy; Carolyn H McCabe; Elliott M Antman; Eugene Braunwald
Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial Infarction 44 trial.
Circulation 2007;116(25):2923-32.
2007: Robert W Yeh; Stephen D Wiviott; Robert P Giugliano; David A Morrow; Amy Shui; Jie Qin; Benjamin M Scirica; James E Bradner; Ik-Kyung Jang; C Michael Gibson; Elliott M Antman
Effect of thrombocytopenia on outcomes following treatment with either enoxaparin or unfractionated heparin in patients presenting with acute coronary syndromes.
The American journal of cardiology 2007;100(12):1734-8.
2007: James A de Lemos; David A Morrow; Michael A Blazing; Petr Jarolim; Stephen D Wiviott; Marc S Sabatine; Robert M Califf; Eugene Braunwald
Serial measurement of monocyte chemoattractant protein-1 after acute coronary syndromes: results from the A to Z trial.
Journal of the American College of Cardiology 2007;50(22):2117-24.
2007: Stephen D Wiviott; Eugene Braunwald; Carolyn H McCabe; Gilles Montalescot; Witold Ruzyllo; Shmuel Gottlieb; Franz-Joseph Neumann; Diego Ardissino; Stefano De Servi; Sabina A Murphy; Jeffrey Riesmeyer; Govinda J Weerakkody; C Michael Gibson; Elliott M Antman
Prasugrel versus clopidogrel in patients with acute coronary syndromes.
The New England journal of medicine 2007;357(20):2001-15.
2007: Christian T Ruff; Stephen D Wiviott; David A Morrow; Satishkumar Mohanavelu; Sabina A Murphy; Elliott M Antman; Eugene Braunwald
TIMI risk index and the benefit of enoxaparin in patients with ST-elevation myocardial infarction.
The American journal of medicine 2007;120(11):993-8.
2007: Stephen D Wiviott; James A de Lemos
Antiplatelet agents make a comeback in ST-elevation myocardial infarction.
American heart journal 2007;154(4):603-6.
2007: Sabina A Murphy; Christopher P Cannon; Stephen D Wiviott; James A de Lemos; Michael A Blazing; Carolyn H McCabe; Robert M Califf; Eugene Braunwald
Effect of intensive lipid-lowering therapy on mortality after acute coronary syndrome (a patient-level analysis of the Aggrastat to Zocor and Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 trials).
The American journal of cardiology 2007;100(7):1047-51.
2007: Benjamin M Scirica; David A Morrow; Christopher P Cannon; James A de Lemos; Sabina Murphy; Marc S Sabatine; Stephen D Wiviott; Nader Rifai; Carolyn H McCabe; Eugene Braunwald
Clinical application of C-reactive protein across the spectrum of acute coronary syndromes.
Clinical chemistry 2007;53(10):1800-7.
2007: Benjamin M Scirica; David A Morrow; Zygmunt Sadowski; Mikhail Ruda; José Carlos Nicolau; Robert P Giugliano; Stephen D Wiviott; Marc S Sabatine; Amy Shui; Elliott M Antman; Eugene Braunwald
A strategy of using enoxaparin as adjunctive antithrombin therapy reduces death and recurrent myocardial infarction in patients who achieve early ST-segment resolution after fibrinolytic therapy: the ExTRACT-TIMI 25 ECG study.
European heart journal 2007;28(17):2070-6.
2007: Jonathan D Rich; Stephen D Wiviott
New antiplatelet therapies for acute coronary syndromes.
Current cardiology reports 2007;9(4):303-11.
2007: Robert P Giugliano; Stephen D Wiviott; Peter H Stone; Daniel I Simon; Marc J Schweiger; Alain Bouchard; Massoud A Leesar; Michael A Goulder; Steven R Deitcher; Carolyn H McCabe; Eugene Braunwald
Recombinant nematode anticoagulant protein c2 in patients with non-ST-segment elevation acute coronary syndrome: the ANTHEM-TIMI-32 trial.
Journal of the American College of Cardiology 2007;49(25):2398-407.
2007: Marc P Bonaca; Stephen D Wiviott; Marc S Sabatine; Jacqueline Buros; Sabina A Murphy; Benjamin M Scirica; Nader Rifai; Elliott M Antman; David A Morrow
Hemodynamic significance of periprocedural myocardial injury assessed with N-terminal pro-B-type natriuretic peptide after percutaneous coronary intervention in patients with stable and unstable coronary artery disease (from the JUMBO-TIMI 26 trial).
The American journal of cardiology 2007;99(3):344-8.
2007: John T Brandt; Christopher D Payne; Stephen D Wiviott; Govinda J Weerakkody; Nagy A Farid; David S Small; Joseph A Jakubowski; Hideo Naganuma; Kenneth J Winters
A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation.
American heart journal 2007;153(1):66.e9-16.
2006: Stephen D Wiviott; Christopher P Cannon
The safety and efficacy of achieving very low LDL-cholesterol concentrations with high dose statin therapy.
Current opinion in lipidology 2006;17(6):626-30.
2006: Michelle O'Donoghue; Stephen D Wiviott
Clopidogrel response variability and future therapies: clopidogrel: does one size fit all?
Circulation 2006;114(22):e600-6.
2006: Stephen D Wiviott
Clopidogrel response variability, resistance, or both?
The American journal of cardiology 2006;98(10A):18N-24N.
2006: Stephen D Wiviott; Elliott M Antman; C Michael Gibson; Gilles Montalescot; Jeffrey Riesmeyer; Govinda J Weerakkody; Kenneth J Winters; Jeffrey W Warmke; Carolyn H McCabe; Eugene Braunwald
Evaluation of prasugrel compared with clopidogrel in patients with acute coronary syndromes: design and rationale for the TRial to assess Improvement in Therapeutic Outcomes by optimizing platelet InhibitioN with prasugrel Thrombolysis In Myocardial Infarction 38 (TRITON-TIMI 38).
American heart journal 2006;152(4):627-35.
2006: Kausik K Ray; Richard G Bach; Christopher P Cannon; Richard Cairns; Ajay J Kirtane; Stephen D Wiviott; Carolyn H McCabe; Eugene Braunwald; C Michael Gibson
Benefits of achieving the NCEP optional LDL-C goal among elderly patients with ACS.
European heart journal 2006;27(19):2310-6.
2006: James A de Lemos; Stephen D Wiviott; Sabina A Murphy; Michael A Blazing; Eldrin F Lewis; Robert M Califf; Marc A Pfeffer; Eugene Braunwald
Evaluation of the National Cholesterol Education Program Adult Treatment Panel III algorithm for selecting candidates for statin therapy: insights from the A to Z trial.
The American journal of cardiology 2006;98(6):739-42.
2006: Stephen D Wiviott; Christopher P Cannon
Update on lipid-lowering therapy and LDL-cholesterol targets.
Nature clinical practice. Cardiovascular medicine 2006;3(8):424-36.
2006: David A Morrow; James A de Lemos; Marc S Sabatine; Stephen D Wiviott; Michael A Blazing; Amy Shui; Nader Rifai; Robert M Califf; Eugene Braunwald
Clinical relevance of C-reactive protein during follow-up of patients with acute coronary syndromes in the Aggrastat-to-Zocor Trial.
Circulation 2006;114(4):281-8.
2006: Benjamin M Scirica; Marc S Sabatine; David A Morrow; C Michael Gibson; Sabina A Murphy; Stephen D Wiviott; Robert P Giugliano; Carolyn H McCabe; Christopher P Cannon; Eugene Braunwald
The role of clopidogrel in early and sustained arterial patency after fibrinolysis for ST-segment elevation myocardial infarction: the ECG CLARITY-TIMI 28 Study.
Journal of the American College of Cardiology 2006;48(1):37-42.
2006: Stephen D Wiviott; David A Morrow; Paul D Frederick; Elliott M Antman; Eugene Braunwald
Application of the Thrombolysis in Myocardial Infarction risk index in non-ST-segment elevation myocardial infarction: evaluation of patients in the National Registry of Myocardial Infarction.
Journal of the American College of Cardiology 2006;47(8):1553-8.
2006: Stephen D Wiviott; James A de Lemos; Christopher P Cannon; Michael A Blazing; Sabina A Murphy; Carolyn H McCabe; Robert M Califf; Eugene Braunwald
A tale of two trials: a comparison of the post-acute coronary syndrome lipid-lowering trials A to Z and PROVE IT-TIMI 22.
Circulation 2006;113(11):1406-14.
2006: Stephen D Wiviott; Alan D Michelson; Peter B Berger; Norman E Lepor; Dean J Kereiakes
Therapeutic goals for effective platelet inhibition: a consensus document.
Reviews in cardiovascular medicine 2006;7(4):214-25.
2006: Stephen D Wiviott; Udaya S Tantry; Paul A Gurbel
Clinical applications of antiplatelet therapy.
Reviews in cardiovascular medicine 2006;7(3):130-46; quiz 148-9.
2005: Stephen D Wiviott; Christopher P Cannon; David A Morrow; Kausik K Ray; Marc A Pfeffer; Eugene Braunwald
Can low-density lipoprotein be too low? The safety and efficacy of achieving very low low-density lipoprotein with intensive statin therapy: a PROVE IT-TIMI 22 substudy.
Journal of the American College of Cardiology 2005;46(8):1411-6.
2005: Stephen D Wiviott; Elliott M Antman; Kenneth J Winters; Govinda J Weerakkody; Sabina A Murphy; Bruce D Behounek; Robert J Carney; Charles Lazzam; Raymond G McKay; Carolyn H McCabe; Eugene Braunwald
Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2Y12 antagonist, with clopidogrel in percutaneous coronary intervention: results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial.
Circulation 2005;111(25):3366-73.
2004: C Michael Gibson; Raphaelle L Dumaine; Eli V Gelfand; Sabina A Murphy; David A Morrow; Stephen D Wiviott; Robert P Giugliano; Christopher P Cannon; Elliott M Antman; Eugene Braunwald
Association of glomerular filtration rate on presentation with subsequent mortality in non-ST-segment elevation acute coronary syndrome; observations in 13,307 patients in five TIMI trials.
European heart journal 2004;25(22):1998-2005.
2004: James A de Lemos; Michael A Blazing; Stephen D Wiviott; William E Brady; Harvey D White; Keith A A Fox; Joanne Palmisano; Karen E Ramsey; David W Bilheimer; Eldrin F Lewis; M Pfeffer; Robert M Califf; Eugene Braunwald
Enoxaparin versus unfractionated heparin in patients treated with tirofiban, aspirin and an early conservative initial management strategy: results from the A phase of the A-to-Z trial.
European heart journal 2004;25(19):1688-94.
2004: James A de Lemos; Michael A Blazing; Stephen D Wiviott; Eldrin F Lewis; Keith A A Fox; Harvey D White; Jean-Lucien Rouleau; Terje R Pedersen; Laura H Gardner; Robin Mukherjee; Karen E Ramsey; Joanne Palmisano; David W Bilheimer; Marc A Pfeffer; Robert M Califf; Eugene Braunwald
Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trial.
JAMA : the journal of the American Medical Association 2004;292(11):1307-16.
2004: Stephen D Wiviott; David A Morrow; Paul D Frederick; Robert P Giugliano; C Michael Gibson; Carolyn H McCabe; Christopher P Cannon; Elliott M Antman; Eugene Braunwald
Performance of the thrombolysis in myocardial infarction risk index in the National Registry of Myocardial Infarction-3 and -4: a simple index that predicts mortality in ST-segment elevation myocardial infarction.
Journal of the American College of Cardiology 2004;44(4):783-9.
2004: Stephen D Wiviott; James A de Lemos; David A Morrow
Pathophysiology, prognostic significance and clinical utility of B-type natriuretic peptide in acute coronary syndromes.
Clinica chimica acta; international journal of clinical chemistry 2004;346(2):119-28.
2004: Stephen D Wiviott; Eugene Braunwald
Unstable angina and non-ST-segment elevation myocardial infarction: part II. Coronary revascularization, hospital discharge, and post-hospital care.
American family physician 2004;70(3):535-8.
2004: Stephen D Wiviott; Eugene Braunwald
Unstable angina and non-ST-segment elevation myocardial infarction: part I. Initial evaluation and management, and hospital care.
American family physician 2004;70(3):525-32.
2004: Stephen D Wiviott; Elliott M Antman
Clopidogrel resistance: a new chapter in a fast-moving story.
Circulation 2004;109(25):3064-7.
2004: Stephen D Wiviott; Christopher P Cannon; David A Morrow; Sabina A Murphy; C Michael Gibson; Carolyn H McCabe; Marc S Sabatine; Nader Rifai; Robert P Giugliano; Peter M DiBattiste; Laura A Demopoulos; Elliott M Antman; Eugene Braunwald
Differential expression of cardiac biomarkers by gender in patients with unstable angina/non-ST-elevation myocardial infarction: a TACTICS-TIMI 18 (Treat Angina with Aggrastat and determine Cost of Therapy with an Invasive or Conservative Strategy-Thrombolysis In Myocardial Infarction 18) substudy.
Circulation 2004;109(5):580-6.
2003: C Michael Gibson; Duane S Pinto; Sabina A Murphy; David A Morrow; Hans-Peter Hobbach; Stephen D Wiviott; Robert P Giugliano; Christopher P Cannon; Elliott M Antman; Eugene Braunwald
Association of creatinine and creatinine clearance on presentation in acute myocardial infarction with subsequent mortality.
Journal of the American College of Cardiology 2003;42(9):1535-43.
2000: Andreas Jeron; Gary F Mitchell; Jun Zhou; Mitsunobu Murata; Barry London; Peter D Buckett; Stephen D Wiviott; Gideon Koren
Inducible polymorphic ventricular tachyarrhythmias in a transgenic mouse model with a long Q-T phenotype.
American journal of physiology. Heart and circulatory physiology 2000;278(6):H1891-8.
1999: D M Kaye; Stephen D Wiviott; Ralph A Kelly
Activation of nitric oxide synthase (NOS3) by mechanical activity alters contractile activity in a Ca2+-independent manner in cardiac myocytes: role of troponin I phosphorylation.
Biochemical and biophysical research communications 1999;256(2):398-403.
1997: D M Kaye; Stephen D Wiviott; Lester Kobzik; Ralph A Kelly; T W Smith
S-nitrosothiols inhibit neuronal norepinephrine transport.
The American journal of physiology 1997;272(2 Pt 2):H875-83.
1996: T W Smith; J L Balligand; D M Kaye; Stephen D Wiviott; W W Simmons; X Han; Thomas Michel; K Singh; Ralph A Kelly
The role of the NO pathway in the control of cardiac function.
Journal of cardiac failure 1996;2(4 Suppl):S141-7.
1996: D M Kaye; Stephen D Wiviott; J L Balligand; W W Simmons; T W Smith; Ralph A Kelly
Frequency-dependent activation of a constitutive nitric oxide synthase and regulation of contractile function in adult rat ventricular myocytes.
Circulation research 1996;78(2):217-24.