FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Alexander Wlodawer

Research Profile

Concepts & Ideas

Procedures

Genes & Molecular Sequences

Chemicals & Drugs

Phenomena

Physiology

Protein Folding

Living Beings

HIV-1

Co-author Network

Publications

TOP 3
Dongwen Zhou; Isabel F C Batista; Alla Gustchina; Yara A Lobo; Rafael Marques Porto; Maria L V Oliva; Alexander Wlodawer
Crystal Structures of a Plant Trypsin Inhibitor from Enterolobium contortisiliquum (EcTI) and of Its Complex with Bovine Trypsin.
Sergei Pletnev; Dmitry M Chudakov; Zbigniew Dauter; Sergey Lukyanov; Nadya V Pletneva; Ekaterina A Souslova; Alexander Wlodawer; Vladimir Pletnev
Structural basis for bathochromic shift of fluorescence in far-red fluorescent proteins eqFP650 and eqFP670.
Krisztina Matúz; János Mótyán; Mi Li; Alexander Wlodawer; József Tőzsér
Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Alexander Wlodawer (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Dongwen Zhou; Isabel F C Batista; Alla Gustchina; Yara A Lobo; Rafael Marques Porto; Maria L V Oliva; Alexander Wlodawer
Crystal Structures of a Plant Trypsin Inhibitor from Enterolobium contortisiliquum (EcTI) and of Its Complex with Bovine Trypsin.
PloS one 2013;8(4):e62252.
2012: Sergei Pletnev; Dmitry M Chudakov; Zbigniew Dauter; Sergey Lukyanov; Nadya V Pletneva; Ekaterina A Souslova; Alexander Wlodawer; Vladimir Pletnev
Structural basis for bathochromic shift of fluorescence in far-red fluorescent proteins eqFP650 and eqFP670.
Acta crystallographica. Section D, Biological crystallography 2012;68(Pt 9):1088-97.
2012: Krisztina Matúz; János Mótyán; Mi Li; Alexander Wlodawer; József Tőzsér
Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin.
The FEBS journal 2012;279(17):3276-86.
2012: Jesper S Oeemig; Alexander Wlodawer; Dongwen Zhou; Tommi Kajander; Hideo Iwaï
NMR and crystal structures of the Pyrococcus horikoshii RadA intein guide a strategy for engineering a highly efficient and promiscuous intein.
Journal of molecular biology 2012;421(1):85-99.
2012: Mauro Acchione; Morgan E DeSantis; Yi-Chien Lee; Mi Li; Claudia A Lipschultz; Aranganathan Shanmuganathan; Sandra J Smith-Gill; Richard L Walter; Alexander Wlodawer; Joseph J Barchi
Specific fluorine labeling of the HyHEL10 antibody affects antigen binding and dynamics.
Biochemistry 2012;51(30):6017-27.
2012: Sergei Pletnev; Fedor V. Subach; Zbigniew Dauter; Alexander Wlodawer; Vladislav Verkhusha
A structural basis for reversible photoswitching of absorbance spectra in red fluorescent protein rsTagRFP.
Journal of molecular biology 2012;417(3):144-51.
2012: Dongwen Zhou; Stuart F J Le Grice; Suhman Chung; Maria Miller; Alexander Wlodawer
Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus.
Journal of structural biology 2012;177(3):638-45.
2012: Prasenjit Bhaumik; Alla Gustchina; Alexander Wlodawer
Structural studies of vacuolar plasmepsins.
Biochimica et biophysica acta 2012;1824(1):207-23.
2011: Mi Li; Krisztina Matúz; Sirilak Namwong; József Tözsér; Ben M Dunn; Nathan E Goldfarb; Alla Gustchina; Alexander Wlodawer
Structural and biochemical characterization of the inhibitor complexes of xenotropic murine leukemia virus-related virus protease.
The FEBS journal 2011;278(22):4413-24.
2011: Prasenjit Bhaumik; Alla Gustchina; Koushi Hidaka; Yoshiaki Kiso; Huogen Xiao; Rickey Y Yada; Alexander Wlodawer
Structural insights into the activation and inhibition of histo-aspartic protease from Plasmodium falciparum.
Biochemistry 2011;50(41):8862-79.
2011: Brian C Bryksa; Dref C De Moura; John R Dutcher; Martin Kurylowicz; Eugenia Magracheva; Alexander Wlodawer; Prasenjit Bhaumik; Alexander Zdanov; Rickey Y Yada
Structure and mechanism of the saposin-like domain of a plant aspartic protease.
The Journal of biological chemistry 2011;286(32):28265-75.
2011: Nadezhda Pletneva; Irina I Shemiakina; Alexander Wlodawer; Vladimir Pletnev; Igor Artemyev; Dmitriy M Chudakov; Zbigniew Dauter; Sergei Pletnev
Crystallographic study of red fluorescent protein eqFP578 and its far-red variant Katushka reveals opposite pH-induced isomerization of chromophore.
Protein science : a publication of the Protein Society 2011;20(7):1265-74.
2011: Prasenjit Bhaumik; Yasumi Horimoto; Huogen Xiao; Takuya Miura; Koushi Hidaka; Yoshiaki Kiso; Alexander Wlodawer; Rickey Y Yada; Alla Gustchina
Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum.
Journal of structural biology 2011;175(1):73-84.
2011: Frank DiMaio; Thomas C Terwilliger; Randy J Read; Alexander Wlodawer; Gustav Oberdorfer; Ulrike Wagner; Eugene Valkov; Assaf Alon; Deborah Fass; Herbert L Axelrod; Debanu Das; Sergey M Vorobiev; Hideo Iwaï; P Raj Pokkuluri; David Baker
Improved molecular replacement by density- and energy-guided protein structure optimization.
Nature 2011;473(7348):540-3.
2011: Andrzej Lyskowski; Jesper S Oeemig; Anniina Jaakkonen; Katariina Rommi; Frank DiMaio; Dongwen Zhou; Tommi Kajander; David Baker; Alexander Wlodawer; Adrian Goldman; Hideo Iwaï
Cloning, expression, purification, crystallization and preliminary X-ray diffraction data of the Pyrococcus horikoshii RadA intein.
Acta crystallographica. Section F, Structural biology and crystallization communications 2011;67(Pt 5):623-6.
2011: Qin Xu; Jianzhuang Yao; Alexander Wlodawer; Hong Guo
Clarification of the mechanism of acylation reaction and origin of substrate specificity of the serine-carboxyl peptidase sedolisin through QM/MM free energy simulations.
The journal of physical chemistry. B 2011;115(10):2470-6.
2011: Mi Li; Frank Dimaio; Dongwen Zhou; Alla Gustchina; Jacek Lubkowski; Zbigniew Dauter; David Baker; Alexander Wlodawer
Crystal structure of XMRV protease differs from the structures of other retropepsins.
Nature structural & molecular biology 2011;18(2):227-9.
2011: Elena Peletskaya; Mikhail Potapov; Viktor Potapov; Tadashi Satoh; Jerry Alexandratos; Mark Andrake; Ravi S Bojja; Alla Gustchina; Alex Kogon; George Merkel; Alexander Wlodawer; Dongwen Zhou; Anna Marie Skalka
Localization of ASV integrase-DNA contacts by site-directed crosslinking and their structural analysis.
PloS one 2011;6(12):e27751.
2011: Jill Glesner; Alla Gustchina; Martin Himly; Mi Li; Alexander Wlodawer; Sabina Wünschmann; Martin D Chapman; Anna Pomés
Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding.
PloS one 2011;6(7):e22223.
2011: Mi Li; Alla Gustchina; Jill Glesner; Sabina Wünschmann; Lisa D Vailes; Martin D Chapman; Anna Pomés; Alexander Wlodawer
Carbohydrates contribute to the interactions between cockroach allergen Bla g 2 and a monoclonal antibody.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(1):333-40.
2010: Zachary J Miknis; Eugenia Magracheva; Wei Li; Alexander Zdanov; Sergei V Kotenko; Alexander Wlodawer
Crystal structure of human interferon-λ1 in complex with its high-affinity receptor interferon-λR1.
Journal of molecular biology 2010;404(4):650-64.
2010: Maksymilian Chruszcz; Marcin Domagalski; Tomasz Osinski; Alexander Wlodawer; Wladek Minor
Unmet challenges of structural genomics.
Current opinion in structural biology 2010;20(5):587-97.
2010: Tinoush Moulaei; Shilpa R Shenoy; Barbara Giomarelli; Cheryl Thomas; James B McMahon; Zbigniew Dauter; Barry R O'Keefe; Alexander Wlodawer
Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity.
Structure (London, England : 1993) 2010;18(9):1104-15.
2010: Alexander Wlodawer; Jacek Lubkowski; Wladek Minor; Mariusz Jaskolski
Is too 'creative' language acceptable in crystallography?
Acta crystallographica. Section D, Biological crystallography 2010;66(Pt 9):1041-2.
2010: Tinoush Moulaei; Olga Stuchlik; Matthew Reed; Weirong Yuan; Jan Pohl; Wuyuan Lu; Lauren Haugh-Krumpe; Barry R O'Keefe; Alexander Wlodawer
Topology of the disulfide bonds in the antiviral lectin scytovirin.
Protein science : a publication of the Protein Society 2010;19(9):1649-61.
2010: Tadashi Satoh; Mi Li; Jeffrey-Tri Nguyen; Yoshiaki Kiso; Alla Gustchina; Alexander Wlodawer
Crystal structures of inhibitor complexes of human T-cell leukemia virus (HTLV-1) protease.
Journal of molecular biology 2010;401(4):626-41.
2010: Mi Li; Alla Gustchina; Fatima Rasulova; Edward E Melnikov; Michael R Maurizi; Tatyana V Rotanova; Zbigniew Dauter; Alexander Wlodawer
Structure of the N-terminal fragment of Escherichia coli Lon protease.
Acta crystallographica. Section D, Biological crystallography 2010;66(Pt 8):865-73.
2010: Zbigniew Dauter; Mariusz Jaskolski; Alexander Wlodawer
Impact of synchrotron radiation on macromolecular crystallography: a personal view.
Journal of synchrotron radiation 2010;17(4):433-44.
2010: Nadya V Pletneva; Vladimir Pletnev; Konstantin A Lukyanov; Nadya G Gurskaya; Ekaterina A Goryacheva; Vladimir Martynov; Alexander Wlodawer; Zbigniew Dauter; Sergei Pletnev
Structural evidence for a dehydrated intermediate in green fluorescent protein chromophore biosynthesis.
The Journal of biological chemistry 2010;285(21):15978-84.
2010: Arthur H Robbins; Roxana M Coman; Edith Bracho-Sanchez; Marty A Fernandez; C Taylor Gilliland; Mi Li; Mavis Agbandje-McKenna; Alexander Wlodawer; Ben M Dunn; Robert McKenna
Structure of the unbound form of HIV-1 subtype A protease: comparison with unbound forms of proteases from other HIV subtypes.
Acta crystallographica. Section D, Biological crystallography 2010;66(Pt 3):233-42.
2010: Sergei Pletnev; Fedor V. Subach; Zbigniew Dauter; Alexander Wlodawer; Vladislav Verkhusha
Understanding blue-to-red conversion in monomeric fluorescent timers and hydrolytic degradation of their chromophores.
Journal of the American Chemical Society 2010;132(7):2243-53.
2010: Elena Gustchina; Mi Li; John M Louis; D Eric Anderson; John Lloyd; Christian Frisch; Carole A Bewley; Alla Gustchina; Alexander Wlodawer; G Marius Clore
Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41.
PLoS pathogens 2010;6(11):e1001182.
2010: Eugenia Magracheva; Sergei Pletnev; Sergei V Kotenko; Wei Li; Alexander Wlodawer; Alexander Zdanov
Purification, crystallization and preliminary crystallographic studies of the complex of interferon-lambda1 with its receptor.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 1):61-3.
2009: Maria Miller; Zbigniew Dauter; Scott Cherry; Joseph E Tropea; Alexander Wlodawer
Structure of the Taz2 domain of p300: insights into ligand binding.
Acta crystallographica. Section D, Biological crystallography 2009;65(Pt 12):1301-8.
2009: Mauro Acchione; Claudia A Lipschultz; Morgan E DeSantis; Aranganathan Shanmuganathan; Mi Li; Alexander Wlodawer; Sergey Tarasov; Sandra J Smith-Gill
Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHEL-10 family of antibodies.
Molecular immunology 2009;47(2-3):457-64.
2009: Sergei Pletnev; Nadya G Gurskaya; Nadya V Pletneva; Konstantin A Lukyanov; Dmitri M Chudakov; Vladimir Martynov; Vladimir O Popov; Mikhail V Kovalchuk; Alexander Wlodawer; Zbigniew Dauter; Vladimir Pletnev
Structural basis for phototoxicity of the genetically encoded photosensitizer KillerRed.
The Journal of biological chemistry 2009;284(46):32028-39.
2009: Zbigniew Dauter; Alexander Wlodawer
Proteins do not have strong spines after all.
Structure (London, England : 1993) 2009;17(10):1278-9.
2009: Sang-Moon Yun; Tinoush Moulaei; Dan Lim; Jeong K Bang; Jung-Eun Park; Shilpa R Shenoy; Fa Liu; Young H Kang; Chenzhong Liao; Nak-Kyun Soung; Sunhee Lee; Do-Young Yoon; Yoongho Lim; Dong-Hee Lee; Akira Otaka; Ettore Appella; James B McMahon; Marc C Nicklaus; Terrence R Burke; Michael B Yaffe; Alexander Wlodawer; Kyung S Lee
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Nature structural & molecular biology 2009;16(8):876-82.
2009: Eugenia Magracheva; Serguei Kozlov; Colin L Stewart; Alexander Wlodawer; Alexander Zdanov
Structure of the lamin A/C R482W mutant responsible for dominant familial partial lipodystrophy (FPLD).
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 7):665-70.
2009: Mariusz Jaskolski; Jerry N Alexandratos; Grzegorz Bujacz; Alexander Wlodawer
Piecing together the structure of retroviral integrase, an important target in AIDS therapy.
The FEBS journal 2009;276(11):2926-46.
2009: Prasenjit Bhaumik; Huogen Xiao; Charity L Parr; Yoshiaki Kiso; Alla Gustchina; Rickey Y Yada; Alexander Wlodawer
Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum.
Journal of molecular biology 2009;388(3):520-40.
2009: Lisa M Miller Jenkins; Hiroshi Yamaguchi; Ryo Hayashi; Scott Cherry; Joseph E Tropea; Maria Miller; Alexander Wlodawer; Ettore Appella; Sharlyn J Mazur
Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation.
Biochemistry 2009;48(6):1244-55.
2009: Hanqiao Feng; Lisa M Miller Jenkins; Stewart R Durell; Ryo Hayashi; Sharlyn J Mazur; Scott Cherry; Joseph E Tropea; Maria Miller; Alexander Wlodawer; Ettore Appella; Yawen Bai
Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation.
Structure (London, England : 1993) 2009;17(2):202-10.
2008: jamaine davis; Jiawei Wang; Joseph E Tropea; Di Zhang; Zbigniew Dauter; David S Waugh; Alexander Wlodawer
Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri.
Protein science : a publication of the Protein Society 2008;17(12):2167-73.
2008: Sergei Pletnev; Dmitry Shcherbo; Dmitry M Chudakov; Nadezhda Pletneva; Ekaterina M Merzlyak; Alexander Wlodawer; Zbigniew Dauter; Vladimir Pletnev
A crystallographic study of bright far-red fluorescent protein mKate reveals pH-induced cis-trans isomerization of the chromophore.
The Journal of biological chemistry 2008;283(43):28980-7.
2008: Alessandro S Nascimento; Sandra Krauchenco; Alexander M Golubev; Alla Gustchina; Alexander Wlodawer; Igor Polikarpov
Statistical coupling analysis of aspartic proteinases based on crystal structures of the Trichoderma reesei enzyme and its complex with pepstatin A.
Journal of molecular biology 2008;382(3):763-78.
2008: Mi Li; Alla Gustchina; Jerry Alexandratos; Alexander Wlodawer; Sabina Wünschmann; Christopher L Kepley; Martin D Chapman; Anna Pomés
Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody.
The Journal of biological chemistry 2008;283(33):22806-14.
2008: Maksymilian Chruszcz; Alexander Wlodawer; Wladek Minor
Determination of protein structures--a series of fortunate events.
Biophysical journal 2008;95(1):1-9.
2008: Alexander Zdanov; Alexander Wlodawer
A new look at cytokine signaling.
Cell 2008;132(2):179-81.
2008: Edward E Melnikov; Anna G Andrianova; Andrey D Morozkin; Anton A Stepnov; Oksana V Makhovskaya; Istvan Botos; Alla Gustchina; Alexander Wlodawer; Tatyana V Rotanova
Limited proteolysis of E. coli ATP-dependent protease Lon - a unified view of the subunit architecture and characterization of isolated enzyme fragments.
Acta biochimica Polonica 2008;55(2):281-96.
2008: Alexander Wlodawer; Wladek Minor; Zbigniew Dauter; Mariusz Jaskolski
Protein crystallography for non-crystallographers, or how to get the best (but not more) from published macromolecular structures.
The FEBS journal 2008;275(1):1-21.
2007: Mariusz Jaskolski; Miroslaw Gilski; Zbigniew Dauter; Alexander Wlodawer
Numerology versus reality: a voice in a recent dispute.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 12):1282-3.
2007: Tinoush Moulaei; Istvan Botos; Natasza E Ziółkowska; Heidi R Bokesch; Lauren R Krumpe; Tawnya C McKee; Barry R O'Keefe; Zbigniew Dauter; Alexander Wlodawer
Atomic-resolution crystal structure of the antiviral lectin scytovirin.
Protein science : a publication of the Protein Society 2007;16(12):2756-60.
2007: Istvan Botos; Alexander Wlodawer
The expanding diversity of serine hydrolases.
Current opinion in structural biology 2007;17(6):683-90.
2007: Nadezhda Pletneva; Vladimir Pletnev; Tamara V Tikhonova; Alexey A Pakhomov; Vladimir Popov; Vladimir Martynov; Alexander Wlodawer; Zbigniew Dauter; Sergei Pletnev
Refined crystal structures of red and green fluorescent proteins from the button polyp Zoanthus.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 10):1082-93.
2007: Nadezhda Pletneva; Sergei Pletnev; D M Chudakov; Tamara V Tikhonova; Vladimir O Popov; Vladimir Martynov; Alexander Wlodawer; Z Dauter; Vladimir Pletnev
[Three-dimensional structure of yellow fluorescent protein zYFP538 from Zoanthus sp. at the resolution 1.8 angstrom].
Bioorganicheskaia khimiia 2007;33(4):421-30.
2007: Jiawei Wang; Alexander Wlodawer; Zbigniew Dauter
What happens when the signs of anomalous differences or the handedness of substructure are inverted?
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 7):751-8.
2007: Natasza E Ziółkowska; Shilpa R Shenoy; Barry R O'Keefe; Alexander Wlodawer
Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine.
Protein science : a publication of the Protein Society 2007;16(7):1485-9.
2007: Mario Sanches; Sandra Krauchenco; Nadia H Martins; Alla Gustchina; Alexander Wlodawer; Igor Polikarpov
Structural characterization of B and non-B subtypes of HIV-protease: insights into the natural susceptibility to drug resistance development.
Journal of molecular biology 2007;369(4):1029-40.
2007: Natasza E Ziółkowska; Shilpa R Shenoy; Barry R O'Keefe; James B McMahon; Kenneth Edward Palmer; Raymond A Dwek; Mark R Wormald; Alexander Wlodawer
Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin.
Proteins 2007;67(3):661-70.
2007: Mariusz Jaskolski; Miroslaw Gilski; Zbigniew Dauter; Alexander Wlodawer
Stereochemical restraints revisited: how accurate are refinement targets and how much should protein structures be allowed to deviate from them?
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 5):611-20.
2007: Qin Xu; Hao-Bo Guo; Alexander Wlodawer; Toru Nakayama; Hong Guo
The QM/MM molecular dynamics and free energy simulations of the acylation reaction catalyzed by the serine-carboxyl peptidase kumamolisin-As.
Biochemistry 2007;46(12):3784-92.
2007: Alexander Wlodawer
Deposition of structural data redux.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 3):421-3.
2007: Diogo Ribeiro Demartini; Alexander Wlodawer; Célia R Carlini
A comparative study of the expression of serine proteinases in quiescent seeds and in developing Canavalia ensiformis plants.
Journal of experimental botany 2007;58(3):521-32.
2007: Nicole A. LaRonde-LeBlanc; Arti N Santhanam; Alyson R Baker; Alexander Wlodawer; Nancy H Colburn
Structural basis for inhibition of translation by the tumor suppressor Pdcd4.
Molecular and cellular biology 2007;27(1):147-56.
2006: Tatyana V Rotanova; Istvan Botos; Edward E Melnikov; Fatima Rasulova; Alla Gustchina; Michael R Maurizi; Alexander Wlodawer
Slicing a protease: structural features of the ATP-dependent Lon proteases gleaned from investigations of isolated domains.
Protein science : a publication of the Protein Society 2006;15(8):1815-28.
2006: Haobo Guo; Alexander Wlodawer; Toru Nakayama; Qin Xu; Hong Guo
Catalytic role of proton transfers in the formation of a tetrahedral adduct in a serine carboxyl peptidase.
Biochemistry 2006;45(30):9129-37.
2006: Natasza E Ziółkowska; Barry R O'Keefe; Toshiyuki Mori; Charles Zhu; Barbara Giomarelli; Fakhrieh Vojdani; Kenneth Edward Palmer; James B McMahon; Alexander Wlodawer
Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding.
Structure (London, England : 1993) 2006;14(7):1127-35.
2006: Ayumi Okubo; Mi Li; Masako Ashida; Hiroshi Oyama; Alla Gustchina; Kohei Oda; Ben M Dunn; Alexander Wlodawer; Toru Nakayama
Processing, catalytic activity and crystal structures of kumamolisin-As with an engineered active site.
The FEBS journal 2006;273(11):2563-76.
2006: M D Prasanna; Jiri Vondrasek; Alexander Wlodawer; H Rodriguez; T N Bhat
Chemical compound navigator: a web-based chem-BLAST, chemical taxonomy-based search engine for browsing compounds.
Proteins 2006;63(4):907-17.
2006: Qin Xu; Haobo Guo; Alexander Wlodawer; Hong Guo
The importance of dynamics in substrate-assisted catalysis and specificity.
Journal of the American Chemical Society 2006;128(18):5994-5.
2006: Changyun Xiong; Barry R O'Keefe; Istvan Botos; Alexander Wlodawer; James B McMahon
Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium.
Protein expression and purification 2006;46(2):233-9.
2006: Alla Gustchina; Mariusz Jaskólski; Alexander Wlodawer
Lessons learned fighting HIV can be applied to anti-cancer drug design.
Cell cycle (Georgetown, Tex.) 2006;5(5):463-4.
2006: Mariusz Jaskólski; Mi Li; Gary S Laco; Alla Gustchina; Alexander Wlodawer
Molecular replacement with pseudosymmetry and model dissimilarity: a case study.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 2):208-15.
2006: Natasza E Ziółkowska; Alexander Wlodawer
Structural studies of algal lectins with anti-HIV activity.
Acta biochimica Polonica 2006;53(4):617-26.
2005: Nicole A. LaRonde-LeBlanc; Alexander Wlodawer
The RIO kinases: an atypical protein kinase family required for ribosome biogenesis and cell cycle progression.
Biochimica et biophysica acta 2005;1754(1-2):14-24.
2005: Mi Li; Gary S Laco; Mariusz Jaskolski; Jan Rozycki; Jerry Alexandratos; Alexander Wlodawer; Alla Gustchina
Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18332-7.
2005: Haobo Guo; Alexander Wlodawer; Hong Guo
A general acid-base mechanism for the stabilization of a tetrahedral adduct in a serine-carboxyl peptidase: a computational study.
Journal of the American Chemical Society 2005;127(45):15662-3.
2005: Nicole A. LaRonde-LeBlanc; Alexander Wlodawer
A family portrait of the RIO kinases.
The Journal of biological chemistry 2005;280(45):37297-300.
2005: Mi Li; Fatima Rasulova; Edward E Melnikov; Tatyana V Rotanova; Alla Gustchina; Michael R Maurizi; Alexander Wlodawer
Crystal structure of the N-terminal domain of E. coli Lon protease.
Protein science : a publication of the Protein Society 2005;14(11):2895-900.
2005: Istvan Botos; Edward E Melnikov; Scott Cherry; Serguei Kozlov; Oksana V Makhovskaya; Joseph E Tropea; Alla Gustchina; Tatyana V Rotanova; Alexander Wlodawer
Atomic-resolution crystal structure of the proteolytic domain of Archaeoglobus fulgidus lon reveals the conformational variability in the active sites of lon proteases.
Journal of molecular biology 2005;351(1):144-57.
2005: Hiroshi Oyama; Tomoko Fujisawa; Takao Suzuki; Ben M Dunn; Alexander Wlodawer; Kohei Oda
Catalytic residues and substrate specificity of recombinant human tripeptidyl peptidase I (CLN2).
Journal of biochemistry 2005;138(2):127-34.
2005: Alexander Wlodawer
Giving credit where credit is due.
Nature structural & molecular biology 2005;12(8):634; discussion 634.
2005: Nicole A. LaRonde-LeBlanc; Tad Guszczynski; Terry D Copeland; Alexander Wlodawer
Structure and activity of the atypical serine kinase Rio1.
The FEBS journal 2005;272(14):3698-713.
2005: Zbigniew Dauter; Istvan Botos; Nicole A. LaRonde-LeBlanc; Alexander Wlodawer
Pathological crystallography: case studies of several unusual macromolecular crystals.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 7):967-75.
2005: Ashraf Brik; Jerry Alexandratos; Ying-Chuan Lin; John H Elder; Arthur J Olson; Alexander Wlodawer; David S Goodsell; Chi-Huey Wong
1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors.
Chembiochem : a European journal of chemical biology 2005;6(7):1167-9.
2005: M D Prasanna; Jiri Vondrasek; Alexander Wlodawer; T N Bhat
Application of InChI to curate, index, and query 3-D structures.
Proteins 2005;60(1):1-4.
2005: Nicole A. LaRonde-LeBlanc; Tad Guszczynski; Terry D Copeland; Alexander Wlodawer
Autophosphorylation of Archaeoglobus fulgidus Rio2 and crystal structures of its nucleotide-metal ion complexes.
The FEBS journal 2005;272(11):2800-10.
2005: Istvan Botos; Alexander Wlodawer
Proteins that bind high-mannose sugars of the HIV envelope.
Progress in biophysics and molecular biology 2005;88(2):233-82.
2005: Alla Gustchina; Mi Li; Sabina Wünschmann; Martin D Chapman; Anna Pomés; Alexander Wlodawer
Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition.
Journal of molecular biology 2005;348(2):433-44.
2005: Halina Zakowicz; Hsin-Sheng Yang; Cristi Stark; Alexander Wlodawer; Nicole A. LaRonde-LeBlanc; Nancy H Colburn
Mutational analysis of the DEAD-box RNA helicase eIF4AII characterizes its interaction with transformation suppressor Pdcd4 and eIF4GI.
RNA (New York, N.Y.) 2005;11(3):261-74.
2005: Adlina Mohd Yusof; Nien-Jen Hu; Alexander Wlodawer; Andreas Hofmann
Structural evidence for variable oligomerization of the N-terminal domain of cyclase-associated protein (CAP).
Proteins 2005;58(2):255-62.
2005: Sergei Pletnev; Eugenia Magracheva; Alexander Wlodawer; Alexander Zdanov
A model of the ternary complex of interleukin-10 with its soluble receptors.
BMC structural biology 2005;5():10.
2005: József Tözsér; Joseph E Tropea; Scott Cherry; Péter Bagossi; Terry D Copeland; Alexander Wlodawer; David S Waugh
Comparison of the substrate specificity of two potyvirus proteases.
The FEBS journal 2005;272(2):514-23.
2004: Tatyana V Rotanova; Edward E Melnikov; Anna G Khalatova; Oksana V Makhovskaya; Istvan Botos; Alexander Wlodawer; Alla Gustchina
Classification of ATP-dependent proteases Lon and comparison of the active sites of their proteolytic domains.
European journal of biochemistry / FEBS 2004;271(23-24):4865-71.
2004: Changsoo Chang; Andreas Plückthun; Alexander Wlodawer
Crystal structure of a truncated version of the phage lambda protein gpD.
Proteins 2004;57(4):866-8.
2004: Patrik Forrer; Changsoo Chang; David Ott; Alexander Wlodawer; Andreas Plückthun
Kinetic stability and crystal structure of the viral capsid protein SHP.
Journal of molecular biology 2004;344(1):179-93.
2004: Nicole A. LaRonde-LeBlanc; Alexander Wlodawer
Crystal structure of A. fulgidus Rio2 defines a new family of serine protein kinases.
Structure (London, England : 1993) 2004;12(9):1585-94.
2004: Alexander Wlodawer
How to kill an enzyme (in more ways than one).
Structure (London, England : 1993) 2004;12(7):1117-9.
2004: Alexander Wlodawer; Mi Li; Alla Gustchina; Naoki Tsuruoka; Masako Ashida; Hiroyuki Minakata; Hiroshi Oyama; Kohei Oda; Tokuzo Nishino; Toru Nakayama
Crystallographic and biochemical investigations of kumamolisin-As, a serine-carboxyl peptidase with collagenase activity.
The Journal of biological chemistry 2004;279(20):21500-10.
2004: Istvan Botos; Edward E Melnikov; Scott Cherry; Anna G Khalatova; Fatima Rasulova; Joseph E Tropea; Michael R Maurizi; Tatyana V Rotanova; Alla Gustchina; Alexander Wlodawer
Crystal structure of the AAA+ alpha domain of E. coli Lon protease at 1.9A resolution.
Journal of structural biology 2004;146(1-2):113-22.
2004: Istvan Botos; Edward E Melnikov; Scott Cherry; Joseph E Tropea; Anna G Khalatova; Fatima Rasulova; Zbigniew Dauter; Michael R Maurizi; Tatyana V Rotanova; Alexander Wlodawer; Alla Gustchina
The catalytic domain of Escherichia coli Lon protease has a unique fold and a Ser-Lys dyad in the active site.
The Journal of biological chemistry 2004;279(9):8140-8.
2004: Alexander Wlodawer; Mi Li; Alla Gustchina; Hiroshi Oyama; Kohei Oda; Bret B Beyer; Jose Clemente; Ben M Dunn
Two inhibitor molecules bound in the active site of Pseudomonas sedolisin: a model for the bi-product complex following cleavage of a peptide substrate.
Biochemical and biophysical research communications 2004;314(2):638-45.
2003: Alexander Wlodawer; Stewart R Durell; Mi Li; Hiroshi Oyama; Kohei Oda; Ben M Dunn
A model of tripeptidyl-peptidase I (CLN2), a ubiquitous and highly conserved member of the sedolisin family of serine-carboxyl peptidases.
BMC structural biology 2003;3():8.
2003: Sergei Pletnev; Eugenia Magracheva; Serguei Kozlov; Gregory Tobin; Sergei V Kotenko; Alexander Wlodawer; Alexander Zdanov
Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20.
Biochemistry 2003;42(43):12617-24.
2003: A S Zhdanov; Jason Phan; Artem G Evdokimov; Joseph E Tropea; Rachel B Kapust; Mi Li; Alexander Wlodawer; David S Waugh
[Tobacco etch virus proteinase: crystal structure of the active enzyme and its inactive mutant].
Bioorganicheskaia khimiia 2003;29(5):457-60.
2003: Sabine Breinig; Jukka Kervinen; Linda Stith; Andrew S Wasson; Robert Fairman; Alexander Wlodawer; Alexander Zdanov; Eileen K Jaffe
Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase.
Nature structural biology 2003;10(9):757-63.
2003: Andreas Hofmann; Deborah P Delmer; Alexander Wlodawer
The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 cluster.
European journal of biochemistry / FEBS 2003;270(12):2557-64.
2003: Changsoo Chang; Eugenia Magracheva; Serguei Kozlov; Steven Fong; Gregory Tobin; Sergei V Kotenko; Alexander Wlodawer; Alexander Zdanov
Crystal structure of interleukin-19 defines a new subfamily of helical cytokines.
The Journal of biological chemistry 2003;278(5):3308-13.
2003: Alexander Wlodawer; Mi Li; Alla Gustchina; Hiroshi Oyama; Ben M Dunn; Kohei Oda
Structural and enzymatic properties of the sedolisin family of serine-carboxyl peptidases.
Acta biochimica Polonica 2003;50(1):81-102.
2003: Jacek Lubkowski; Miroslawa Dauter; Khosrow Aghaiypour; Alexander Wlodawer; Zbigniew Dauter
Atomic resolution structure of Erwinia chrysanthemi L-asparaginase.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 1):84-92.
2002: Jason Phan; Alexander Zdanov; Artem G Evdokimov; Joseph E Tropea; Howard K Peters; Rachel B Kapust; Mi Li; Alexander Wlodawer; David S Waugh
Structural basis for the substrate specificity of tobacco etch virus protease.
The Journal of biological chemistry 2002;277(52):50564-72.
2002: Jiri Vondrasek; Alexander Wlodawer
HIVdb: a database of the structures of human immunodeficiency virus protease.
Proteins 2002;49(4):429-31.
2002: Andreas Hofmann; Sonja Hess; Angelika A Noegel; Michael Schleicher; Alexander Wlodawer
Crystallization of cyclase-associated protein from Dictyostelium discoideum.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 10 Pt 2):1858-61.
2002: Istvan Botos; Barry R O'Keefe; Shilpa R Shenoy; Laura K Cartner; Daniel M Ratner; Peter H Seeberger; Michael R Boyd; Alexander Wlodawer
Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides.
The Journal of biological chemistry 2002;277(37):34336-42.
2002: Andreas Hofmann; Hideo Iwai; Sonja Hess; Andreas Plückthun; Alexander Wlodawer
Structure of cyclized green fluorescent protein.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 9):1400-6.
2002: Alexander Wlodawer
Structure-based design of AIDS drugs and the development of resistance.
Vox sanguinis 2002;83 Suppl 1():23-6.
2002: Andreas Hofmann; Sergei Ruvinov; Sonja Hess; Rodolphe Schantz; Deborah P Delmer; Alexander Wlodawer
Plant annexins form calcium-independent oligomers in solution.
Protein science : a publication of the Protein Society 2002;11(8):2033-40.
2002: Alla Gustchina; Mi Li; Lowri H Phylip; Wendy E Lees; John Kay; Alexander Wlodawer
An unusual orientation for Tyr75 in the active site of the aspartic proteinase from Saccharomyces cerevisiae.
Biochemical and biophysical research communications 2002;295(4):1020-6.
2002: Istvan Botos; Toshiyuki Mori; Laura K Cartner; Michael R Boyd; Alexander Wlodawer
Domain-swapped structure of a mutant of cyanovirin-N.
Biochemical and biophysical research communications 2002;294(1):184-90.
2002: Eileen K Jaffe; Jukka Kervinen; Jacob Martins; Frédéric Stauffer; Reinhard Neier; Alexander Wlodawer; Alexander Zdanov
Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid.
The Journal of biological chemistry 2002;277(22):19792-9.
2002: Laura G Barrientos; John M Louis; Istvan Botos; Toshiyuki Mori; Zhaozhong Han; Barry R O'Keefe; Michael R Boyd; Alexander Wlodawer; Angela M Gronenborn
The domain-swapped dimer of cyanovirin-N is in a metastable folded state: reconciliation of X-ray and NMR structures.
Structure (London, England : 1993) 2002;10(5):673-86.
2002: Changsoo Chang; Dianne L Newton; Susanna M Rybak; Alexander Wlodawer
Crystallographic and functional studies of a modified form of eosinophil-derived neurotoxin (EDN) with novel biological activities.
Journal of molecular biology 2002;317(1):119-30.
2002: Andreas Hofmann; Sergey Tarasov; Melissa Grella; Sergei Ruvinov; Fahd Nasr; Witold Filipowicz; Alexander Wlodawer
Biophysical characterization of cyclic nucleotide phosphodiesterases.
Biochemical and biophysical research communications 2002;291(4):875-83.
2002: Andreas Hofmann; Melissa Grella; Istvan Botos; Witold Filipowicz; Alexander Wlodawer
Crystal structures of the semireduced and inhibitor-bound forms of cyclic nucleotide phosphodiesterase from Arabidopsis thaliana.
The Journal of biological chemistry 2002;277(2):1419-25.
2002: Ben M Dunn; Maureen M Goodenow; Alla Gustchina; Alexander Wlodawer
Retroviral proteases.
Genome biology 2002;3(4):REVIEWS3006.
2002: Alexander Wlodawer
Rational approach to AIDS drug design through structural biology.
Annual review of medicine 2002;53():595-614.
2001: Alexander Wlodawer; M Li; Alla Gustchina; Zbigniew Dauter; K Uchida; H Oyama; N E Goldfarb; Ben M Dunn; Kohei Oda
Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase.
Biochemistry 2001;40(51):15602-11.
2001: Khosrow Aghaiypour; Alexander Wlodawer; Jacek Lubkowski
Do bacterial L-asparaginases utilize a catalytic triad Thr-Tyr-Glu?
Biochimica et biophysica acta 2001;1550(2):117-28.
2001: Istvan Botos; Zhibin Wu; Wuyuan Lu; Alexander Wlodawer
Crystal structure of a cyclic form of bovine pancreatic trypsin inhibitor.
FEBS letters 2001;509(1):90-4.
2001: Jukka Kervinen; Eileen K Jaffe; Frédéric Stauffer; Reinhard Neier; Alexander Wlodawer; Alexander Zdanov
Mechanistic basis for suicide inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid, an inhibitor that shows dramatic species selectivity.
Biochemistry 2001;40(28):8227-36.
2001: C Chang; A Mooser; Andreas Plückthun; Alexander Wlodawer
Crystal structure of the dimeric C-terminal domain of TonB reveals a novel fold.
The Journal of biological chemistry 2001;276(29):27535-40.
2001: Khosrow Aghaiypour; Alexander Wlodawer; Jacek Lubkowski
Structural basis for the activity and substrate specificity of Erwinia chrysanthemi L-asparaginase.
Biochemistry 2001;40(19):5655-64.
2001: Alexander Wlodawer; Mi Li; Zbigniew Dauter; Alla Gustchina; K Uchida; Hiroshi Oyama; Ben M Dunn; Kohei Oda
Carboxyl proteinase from Pseudomonas defines a novel family of subtilisin-like enzymes.
Nature structural biology 2001;8(5):442-6.
2001: Mariusz Jaskólski; Maciej Kozak; J Lubkowski ; G Palm ; Alexander Wlodawer
Structures of two highly homologous bacterial L-asparaginases: a case of enantiomorphic space groups.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 3):369-77.
2001: Zbigniew Dauter; M Li; Alexander Wlodawer
Practical experience with the use of halides for phasing macromolecular structures: a powerful tool for structural genomics.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 2):239-49.
2001: Lowri H Phylip; Wendy E Lees; B G Brownsey; Daniel Bur; Ben M Dunn; J R Winther; Alla Gustchina; Mi Li; T Copeland; Alexander Wlodawer; John Kay
The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiae.
The Journal of biological chemistry 2001;276(3):2023-30.
2000: Andreas Hofmann; Alexander Zdanov; P Genschik; Sergei Ruvinov; Witold Filipowicz; Alexander Wlodawer
Structure and mechanism of activity of the cyclic phosphodiesterase of Appr>p, a product of the tRNA splicing reaction.
The EMBO journal 2000;19(22):6207-17.
2000: F Yang; Zbigniew Dauter; Alexander Wlodawer
Effects of crystal twinning on the ability to solve a macromolecular structure using multiwavelength anomalous diffraction.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 8):959-64.
2000: Alexander Wlodawer; Alla Gustchina
Structural and biochemical studies of retroviral proteases.
Biochimica et biophysica acta 2000;1477(1-2):16-34.
2000: F Yang; P Forrer; Z Dauter; James F Conway; Naiqian Cheng; Mario E Cerritelli; Alasdair C Steven; A Plückthun; Alexander Wlodawer
Novel fold and capsid-binding properties of the lambda-phage display platform protein gpD.
Nature structural biology 2000;7(3):230-7.
2000: Mi Li; Lowri H Phylip; Wendy E Lees; J R Winther; Ben M Dunn; Alexander Wlodawer; John Kay; Alla Gustchina
The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix.
Nature structural biology 2000;7(2):113-7.
2000: M Li; Garrett M Morris; T Lee; Gary S Laco; C H Wong; Arthur J Olson; John H Elder; Alexander Wlodawer; Alla Gustchina
Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease.
Proteins 2000;38(1):29-40.
1999: Jacek Lubkowski; Z Dauter; F Yang; Jerry Alexandratos; George Merkel; Anna Marie Skalka; Alexander Wlodawer
Atomic resolution structures of the core domain of avian sarcoma virus integrase and its D64N mutant.
Biochemistry 1999;38(41):13512-22.
1999: Jukka Kervinen; Gregory Tobin; Júlia Costa; David S Waugh; Alexander Wlodawer; Alexander Zdanov
Crystal structure of plant aspartic proteinase prophytepsin: inactivation and vacuolar targeting.
The EMBO journal 1999;18(14):3947-55.
1999: Jacek Lubkowski; F Hennecke; A Plückthun; Alexander Wlodawer
Filamentous phage infection: crystal structure of g3p in complex with its coreceptor, the C-terminal domain of TolA.
Structure (London, England : 1993) 1999;7(6):711-22.
1999: F Yang; Carole A Bewley; J M Louis; K R Gustafson; M R Boyd; A M Gronenborn; G M Clore; Alexander Wlodawer
Crystal structure of cyanovirin-N, a potent HIV-inactivating protein, shows unexpected domain swapping.
Journal of molecular biology 1999;288(3):403-12.
1999: D M Hoover; C Schalk-Hihi; C C Chou; S Menon; Alexander Wlodawer; Alexander Zdanov
Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization.
European journal of biochemistry / FEBS 1999;262(1):134-41.
1999: Alexander Wlodawer
Crystal structures of catalytic core domains of retroviral integrases and role of divalent cations in enzymatic activity.
Advances in virus research 1999;52():335-50.
1999: Jacek Lubkowski; Alexander Wlodawer
Decamers observed in the crystals of bovine pancreatic trypsin inhibitor.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):335-7.
1998: Jacek Lubkowski; F Yang; Jerry Alexandratos; George Merkel; Richard Katz; K Gravuer; Anna Marie Skalka; Alexander Wlodawer
Structural basis for inactivating mutations and pH-dependent activity of avian sarcoma virus integrase.
The Journal of biological chemistry 1998;273(49):32685-9.
1998: S Glathe; Jukka Kervinen; M Nimtz; G H Li; Gregory Tobin; T D Copeland; David A Ashford; Alexander Wlodawer; Júlia Costa
Transport and activation of the vacuolar aspartic proteinase phytepsin in barley (Hordeum vulgare L.).
The Journal of biological chemistry 1998;273(47):31230-6.
1998: J K Rao; G Bujacz; Alexander Wlodawer
Crystal structure of rabbit muscle creatine kinase.
FEBS letters 1998;439(1-2):133-7.
1998: Jukka Kervinen; Jacek Lubkowski; Alexander Zdanov; D Bhatt; Ben M Dunn; K Y Hui; David J Powell; John Kay; Alexander Wlodawer; Alla Gustchina
Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV.
Protein science : a publication of the Protein Society 1998;7(11):2314-23.
1998: F Yang; K R Gustafson; M R Boyd; Alexander Wlodawer
Crystal structure of Escherichia coli HdeA.
Nature structural biology 1998;5(9):763-4.
1998: Jacek Lubkowski; F Yang; Jerry Alexandratos; Alexander Wlodawer; H Zhao; T R Burke; N Neamati; Y Pommier; George Merkel; Anna Marie Skalka
Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):4831-6.
1998: Jacek Lubkowski; F Hennecke; A Plückthun; Alexander Wlodawer
The structural basis of phage display elucidated by the crystal structure of the N-terminal domains of g3p.
Nature structural biology 1998;5(2):140-7.
1998: Alexander Wlodawer; Jiri Vondrasek
Inhibitors of HIV-1 protease: a major success of structure-assisted drug design.
Annual review of biophysics and biomolecular structure 1998;27():249-84.
1998: David J Powell; Daniel Bur; Alexander Wlodawer; Alla Gustchina; Ben M Dunn; John Kay
The aspartic proteinase from equine infectious anaemia virus.
Advances in experimental medicine and biology 1998;436():41-5.
1997: G Bujacz; M Miller; Robert W Harrison; Narmada Thanki; Gary L Gilliland; C M Ogata; S H Kim; Alexander Wlodawer
Structure of monellin refined to 2.3 a resolution in the orthorhombic crystal form.
Acta crystallographica. Section D, Biological crystallography 1997;53(Pt 6):713-9.
1997: Gary S Laco; C Schalk-Hihi; Jacek Lubkowski; G Morris; Alexander Zdanov; A Olson; John H Elder; Alexander Wlodawer; Alla Gustchina
Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor.
Biochemistry 1997;36(35):10696-708.
1997: G Bujacz; Jerry Alexandratos; Alexander Wlodawer; George Merkel; Mark D Andrake; Richard Katz; Anna Marie Skalka
Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity.
The Journal of biological chemistry 1997;272(29):18161-8.
1997: Alexander Zdanov; C Schalk-Hihi; S Menon; K W Moore; Alexander Wlodawer
Crystal structure of Epstein-Barr virus protein BCRF1, a homolog of cellular interleukin-10.
Journal of molecular biology 1997;268(2):460-7.
1997: Jiri Vondrasek; Alexander Wlodawer
Database of HIV proteinase structures.
Trends in biochemical sciences 1997;22(5):183.
1997: Alexander Wlodawer
Deposition of macromolecular coordinates resulting from crystallographic and NMR studies.
Nature structural biology 1997;4(3):173-4.
1997: Júlia Costa; David A Ashford; M Nimtz; Isabel Bento; C Frazäo; C L Esteves; Carlos Faro; Jukka Kervinen; Euclides Pires; Paula Verissimo; Alexander Wlodawer; Maria Arménia Carrondo
The glycosylation of the aspartic proteinases from barley (Hordeum vulgare L.) and cardoon (Cynara cardunculus L.).
European journal of biochemistry / FEBS 1997;243(3):695-700.
1997: Jacek Lubkowski; G Bujacz; L Boqué; Peter J Domaille; Tracy M Handel; Alexander Wlodawer
The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions.
Nature structural biology 1997;4(1):64-9.
1997: Jiri Vondrasek; C P van Buskirk; Alexander Wlodawer
Database of three-dimensional structures of HIV proteinases.
Nature structural biology 1997;4(1):8.
1996: G Bujacz; Jerry Alexandratos; Z L Qing; C Clément-Mella; Alexander Wlodawer
The catalytic domain of human immunodeficiency virus integrase: ordered active site in the F185H mutant.
FEBS letters 1996;398(2-3):175-8.
1996: M Jaskólski; Alexander Wlodawer
A minimalist's approach to the phase problem - phasing selenomethionyl protein structures using Cu Kalpha data.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 6):1075-81.
1996: David J Powell; Daniel Bur; Alexander Wlodawer; Alla Gustchina; S L Payne; Ben M Dunn; J Kay
Expression, characterisation and mutagenesis of the aspartic proteinase from equine infectious anaemia virus.
European journal of biochemistry / FEBS 1996;241(2):664-74.
1996: Jacek Lubkowski; G J Palm; Gary L Gilliland; Christian Derst; Klaus-Heinrich Röhm; Alexander Wlodawer
Crystal structure and amino acid sequence of Wolinella succinogenes L-asparaginase.
European journal of biochemistry / FEBS 1996;241(1):201-7.
1996: Alexander Zdanov; C Schalk-Hihi; Alexander Wlodawer
Crystal structure of human interleukin-10 at 1.6 A resolution and a model of a complex with its soluble receptor.
Protein science : a publication of the Protein Society 1996;5(10):1955-62.
1996: Martina Schnölzer; Hans-Richard Rackwitz; Alla Gustchina; Gary S Laco; Alexander Wlodawer; John H Elder; SB Kent
Comparative properties of feline immunodeficiency virus (FIV) and human immunodeficiency virus type 1 (HIV-1) proteinases prepared by total chemical synthesis.
Virology 1996;224(1):268-75.
1996: Alla Gustchina; Jukka Kervinen; David J Powell; Alexander Zdanov; J Kay; Alexander Wlodawer
Structure of equine infectious anemia virus proteinase complexed with an inhibitor.
Protein science : a publication of the Protein Society 1996;5(8):1453-65.
1996: G J Palm; Jacek Lubkowski; Christian Derst; S Schleper; Klaus-Heinrich Röhm; Alexander Wlodawer
A covalently bound catalytic intermediate in Escherichia coli asparaginase: crystal structure of a Thr-89-Val mutant.
FEBS letters 1996;390(2):211-6.
1996: G Bujacz; M Jaskólski; Jerry Alexandratos; Alexander Wlodawer; George Merkel; Richard Katz; Anna Marie Skalka
The catalytic domain of avian sarcoma virus integrase: conformation of the active-site residues in the presence of divalent cations.
Structure (London, England : 1993) 1996;4(1):89-96.
1995: G Bujacz; M Jaskólski; Jerry Alexandratos; Alexander Wlodawer; George Merkel; Richard Katz; Anna Marie Skalka
High-resolution structure of the catalytic domain of avian sarcoma virus integrase.
Journal of molecular biology 1995;253(2):333-46.
1995: Alexander Zdanov; C Schalk-Hihi; Alla Gustchina; M Tsang; J Weatherbee; Alexander Wlodawer
Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma.
Structure (London, England : 1993) 1995;3(6):591-601.
1995: Alexander Wlodawer; Alla Gustchina; L Reshetnikova; Jacek Lubkowski; Alexander Zdanov; K Y Hui; E L Angleton; William G Farmerie; Maureen M Goodenow; D Bhatt
Structure of an inhibitor complex of the proteinase from feline immunodeficiency virus.
Nature structural biology 1995;2(6):480-8.
1995: Alexander Wlodawer
Proteasome: a complex protease with a new fold and a distinct mechanism.
Structure (London, England : 1993) 1995;3(5):417-20.
1995: Alla Gustchina; Alexander Zdanov; C Schalk-Hihi; Alexander Wlodawer
A model of the complex between interleukin-4 and its receptors.
Proteins 1995;21(2):140-8.
1994: Jacek Lubkowski; Alexander Wlodawer; D Housset; Irene T Weber; H L Ammon; K C Murphy; A L Swain
Refined crystal structure of Acinetobacter glutaminasificans glutaminase-asparaginase.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 6):826-32.
1994: Jacek Lubkowski; Alexander Wlodawer; H L Ammon; T D Copeland; A L Swain
Structural characterization of Pseudomonas 7A glutaminase-asparaginase.
Biochemistry 1994;33(34):10257-65.
1994: R C Hoffman; C Schalk-Hihi; Beverly J Castner; M G Gibson; B D Rasmussen; Alexander Zdanov; Alla Gustchina; CJ March; Alexander Wlodawer
Stoichiometry of the complex of human interleukin-4 with its receptor.
FEBS letters 1994;347(1):17-21.
1994: Alla Gustchina; C Sansom; M Prevost; J Richelle; S Y Wodak; Alexander Wlodawer; Irene T Weber
Energy calculations and analysis of HIV-1 protease-inhibitor crystal structures.
Protein engineering 1994;7(3):309-17.
1993: Alexander Wlodawer; A Pavlovsky; Alla Gustchina
Hematopoietic cytokines: similarities and differences in the structures, with implications for receptor binding.
Protein science : a publication of the Protein Society 1993;2(9):1373-82.
1993: A T Danishefsky; D Housset; K S Kim; F Tao; J Fuchs; Clare Woodward; Alexander Wlodawer
Crevice-forming mutants in the rigid core of bovine pancreatic trypsin inhibitor: crystal structures of F22A, Y23A, N43G, and F45A.
Protein science : a publication of the Protein Society 1993;2(4):577-87.
1993: K S Kim; F Tao; J Fuchs; A T Danishefsky; D Housset; Alexander Wlodawer; Clare Woodward
Crevice-forming mutants of bovine pancreatic trypsin inhibitor: stability changes and new hydrophobic surface.
Protein science : a publication of the Protein Society 1993;2(4):588-96.
1993: A L Swain; M Jaskólski; D Housset; J K Rao; Alexander Wlodawer
Crystal structure of Escherichia coli L-asparaginase, an enzyme used in cancer therapy.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(4):1474-8.
1993: Alexander Wlodawer; J W Erickson
Structure-based inhibitors of HIV-1 protease.
Annual review of biochemistry 1993;62():543-85.
1992: Alexander Wlodawer; A Wlodaver; A Pavlovsky; Alla Gustchina
Crystal structure of human recombinant interleukin-4 at 2.25 A resolution.
FEBS letters 1992;309(1):59-64.
1992: N Thanki; J K Rao; SI Foundling; W J Howe; J B Moon; J O Hui; Alfredo G Tomasselli; Robert L Heinrikson; S Thaisrivongs; Alexander Wlodawer
Crystal structure of a complex of HIV-1 protease with a dihydroxyethylene-containing inhibitor: comparisons with molecular modeling.
Protein science : a publication of the Protein Society 1992;1(8):1061-72.
1992: Alexander Wlodawer
Another piece of the HIV puzzle falls into place.
Science (New York, N.Y.) 1992;256(5065):1766.
1991: D Housset; K S Kim; J Fuchs; Clare Woodward; Alexander Wlodawer
Crystal structure of a Y35G mutant of bovine pancreatic trypsin inhibitor.
Journal of molecular biology 1991;220(3):757-70.
1991: J K Rao; J W Erickson; Alexander Wlodawer
Structural and evolutionary relationships between retroviral and eucaryotic aspartic proteinases.
Biochemistry 1991;30(19):4663-71.
1991: M Jaskólski; A G Tomasselli; T K Sawyer; D G Staples; R L Heinrikson; J Schneider; S B Kent; Alexander Wlodawer
Structure at 2.5-A resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene-based inhibitor.
Biochemistry 1991;30(6):1600-9.
1991: Alla Gustchina; Irene T Weber; Alexander Wlodawer
Molecular modeling of the HIV-2 protease.
Advances in experimental medicine and biology 1991;306():549-53.
1991: A L Swain; Alla Gustchina; Alexander Wlodawer
Comparison of three inhibitor complexes of human immunodeficiency virus protease.
Advances in experimental medicine and biology 1991;306():433-41.
1990: M Jaskólski; M Miller; J K Rao; J Leis; Alexander Wlodawer
Structure of the aspartic protease from Rous sarcoma retrovirus refined at 2-A resolution.
Biochemistry 1990;29(25):5889-98.
1989: Alexander Wlodawer; M Miller; M Jaskólski; Bangalore Sathyanarayana; E Baldwin; Irene T Weber; L M Selk; L Clawson; J Schneider; S B Kent
Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease.
Science (New York, N.Y.) 1989;245(4918):616-21.
1989: Irene T Weber; M Miller; M Jaskólski; J Leis; A M Skalka; Alexander Wlodawer
Molecular modeling of the HIV-1 protease and its substrate binding site.
Science (New York, N.Y.) 1989;243(4893):928-31.
1989: M Miller; M Jaskólski; J K Rao; J Leis; Alexander Wlodawer
Crystal structure of a retroviral protease proves relationship to aspartic protease family.
Nature 1989;337(6207):576-9.
1989: Alexander Wlodawer; H Savage; G Dodson
Structure of insulin: results of joint neutron and X-ray refinement.
Acta crystallographica. Section B, Structural science 1989;45 ( Pt 1)():99-107.
1988: M Miller; Robert W Harrison; Alexander Wlodawer; E Appella; Joel Sussman
Crystal structure of 15-mer DNA duplex containing unpaired bases.
Nature 1988;334(6177):85-6.
1988: Robert W Harrison; Alexander Wlodawer; Lennart Sjölin
Analysis of solvent structure and hydrogen exchange in proteins on the basis of neutron diffraction data from deuterated and hydrogenous crystals.
Acta crystallographica. Section A, Foundations of crystallography 1988;44 ( Pt 3)():309-20.
1988: Alexander Wlodawer; L A Svensson; Lennart Sjölin; Gary L Gilliland
Structure of phosphate-free ribonuclease A refined at 1.26 A.
Biochemistry 1988;27(8):2705-17.
1988: H L Ammon; Irene T Weber; Alexander Wlodawer; Robert W Harrison; Gary L Gilliland; K C Murphy; Lennart Sjölin; Joseph Roberts
Preliminary crystal structure of Acinetobacter glutaminasificans glutaminase-asparaginase.
The Journal of biological chemistry 1988;263(1):150-6.
1987: Alexander Wlodawer; J Nachman; Gary L Gilliland; W Gallagher; Clare Woodward
Structure of form III crystals of bovine pancreatic trypsin inhibitor.
Journal of molecular biology 1987;198(3):469-80.
1987: M Miller; Alexander Wlodawer; E Appella; Joel Sussman
Crystallization of a DNA duplex 15-mer containing unpaired bases: d(CGCGAAATTTACGCG).
Journal of molecular biology 1987;195(4):967-8.
1986: L A Svensson; Lennart Sjölin; Gary L Gilliland; B C Finzel; Alexander Wlodawer
Multiple conformations of amino acid residues in ribonuclease A.
Proteins 1986;1(4):370-5.
1985: H L Ammon; K C Murphy; K Chandrasekhar; Alexander Wlodawer
Preliminary crystallographic study of an L-asparaginase from Vibrio succinogenes.
Journal of molecular biology 1985;184(1):179-81.