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Roland Wolf

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Colin Henderson; Lesley A McLaughlin; C Roland Wolf
Evidence That Cytochrome b5 and Cytochrome b5 Reductase Can Act as Sole Electron Donors to the Hepatic Cytochrome P450 System.
Andreia Neves Carvalho; Colin J Henderson; Carla Marques; Paulo Pereira; Elsa Rodrigues; C Roland Wolf; Maria João Gama
Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice.
David S Riddick; Sebastien Ronseaux; C Roland Wolf; Qing-Yu Zhang; Ling Zou; Jun Gu; Colin J Henderson; Lesley A McLaughlin; Amit V Pandey; Todd D Porter; Xinxin Ding; Robert D Finn; Christa E Flück
NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.

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All Publications

2013: Colin Henderson; Lesley A McLaughlin; C Roland Wolf
Evidence That Cytochrome b5 and Cytochrome b5 Reductase Can Act as Sole Electron Donors to the Hepatic Cytochrome P450 System.
Molecular pharmacology 2013;83(6):1209-17.
2013: Andreia Neves Carvalho; Colin J Henderson; Carla Marques; Paulo Pereira; Elsa Rodrigues; C Roland Wolf; Maria João Gama
Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice.
Molecular neurobiology 2013;47(2):662-72.
2013: David S Riddick; Sebastien Ronseaux; C Roland Wolf; Qing-Yu Zhang; Ling Zou; Jun Gu; Colin J Henderson; Lesley A McLaughlin; Amit V Pandey; Todd D Porter; Xinxin Ding; Robert D Finn; Christa E Flück
NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(1):12-23.
2012: David J McGarry; C Roland Wolf; Colin J Henderson
Removal notice to “non-catalytic mechanisms involved in glutathione S-transferase Pi mediated cytoprotection” [Toxicology 290 (2011) 130].
Toxicology 2012;302(2-3):321.
2012: Nico Scheer; Sandra Buechel; Lynsey Chatham; Yury Kapelyukh; Anja Rode; C Roland Wolf
Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines.
Molecular pharmacology 2012;82(6):1022-9.
2012: Beate I Escher; Mriga Dutt; Erin Maylin; Janet Y M Tang; Simon Toze; C Roland Wolf; Matti Lang
Water quality assessment using the AREc32 reporter gene assay indicative of the oxidative stress response pathway.
Journal of environmental monitoring : JEM 2012;14(11):2877-85.
2012: Nico Scheer; Praveen Balimane; Sandra Buechel; Michael D Hayward; Gunther Kauselmann; C Roland Wolf
Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(11):2212-8.
2012: G Smith; M J Ferguson; C Gourley; C S Herrington; M T H Ng; L Shepherd; C Roland Wolf
Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer.
British journal of cancer 2012;107(8):1327-36.
2012: M Castro-Caldas; A Neves Carvalho; C J Henderson; C M P Rodrigues; E Rodrigues; C Roland Wolf; M J Gama
Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease.
Molecular neurobiology 2012;46(2):475-86.
2012: Margarida Castro-Caldas; Colin Henderson; Elsa Rodrigues; C Roland Wolf; Andreia Neves Carvalho; Maria João Gama
Glutathione S-transferase pi mediates MPTP-induced c-Jun N-terminal kinase activation in the nigrostriatal pathway.
Molecular neurobiology 2012;45(3):466-77.
2012: Dorota Kostrzewa-Nowak; Mark J I Paine; Bohdan Bieg; C Roland Wolf; Jolanta Tarasiuk
Role of structural factors of antitumour anthraquinone derivatives and analogues in the ability to undergo bioreductive activation by NADPH cytochrome P450 reductase: implications for increasing the activity against sensitive and multidrug-resistant leukaemia HL60 cells.
Anti-cancer drugs 2012;23(4):393-405.
2012: Alison D McNeilly; C Roland Wolf; Julie A Woods; Sally H Ibbotson; Gillian Smith
Characterization of a human keratinocyte HaCaT cell line model to study the regulation of CYP2S1.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(2):283-9.
2012: Clare M Lee; Gino Miele; Manikhandan A V Mudaliar; J Keith Vass; C Roland Wolf; D R Haggart; Desmond J Higham; Daniel Crowther
Simultaneous non-negative matrix factorization for multiple large scale gene expression datasets in toxicology.
PloS one 2012;7(12):e48238.
2012: Larry G Higgins; Sitheswaran Nainamalai; Peter R Ashby; Wojciech G Garbacz; Mattias C U Gustafsson; C Roland Wolf; Colin N A Palmer
Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo.
PPAR research 2012;2012():216817.
2011: Volker M Arlt; James D Evans; Peter B Farmer; Eva Frei; Gonçalo Gamboa da Costa; Colin J Henderson; Rajinder Singh; Marie Stiborová; C Roland Wolf; David H Phillips
Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adduct formation in P450 reductase conditional null mice.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(12):2169-73.
2011: Colin J Henderson; Aileen McLaren; Kenneth J Ritchie; Probir Chakravarty; C Roland Wolf
Increased skin papilloma formation in mice lacking glutathione transferase GSTP.
Cancer research 2011;71(22):7048-60.
2011: Maki Hasegawa; Yury Kapelyukh; Sylvia Krueger; Dongtao N Lee; Anja Rode; Jost Seibler; Harunobu Tahara; C Roland Wolf; Nico Scheer
Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line.
Molecular pharmacology 2011;80(3):518-28.
2011: Agnieszka Potega; Sebastien Ronseaux; C Roland Wolf; Magdalena Niemira; Emilia Dabrowska; Colin J Henderson; Agata Kot-Wasik; Zofia Mazerska
The imidazoacridinone antitumor drug, C-1311, is metabolized by flavin monooxygenases but not by cytochrome P450s.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(8):1423-32.
2011: Colin J Henderson; C Roland Wolf
Knockout and transgenic mice in glutathione transferase research.
Drug metabolism reviews 2011;43(2):152-64.
2011: Katerina Levová; Michaela Moserová; Vera Kotrbová; Miroslav Sulc; Colin Henderson; C Roland Wolf; David H Phillips; Eva Frei; Heinz H Schmeiser; Jaroslav Mares; Volker M Arlt; Marie Stiborová
Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.
Toxicological sciences : an official journal of the Society of Toxicology 2011;121(1):43-56.
2011: Douglas B Vasey; C Roland Wolf; Ken Brown; C Bruce A Whitelaw
Spatial p21 expression profile in the mid-term mouse embryo.
Transgenic research 2011;20(1):23-8.
2011: Matthew P Vaughn; C Roland Wolf; Srinivasan Yegnasubramanian; George Netto; Zachery R Reichert; Traci J Speed; Debika Biswal Shinohara; Nicole Castagna; Angelo M DeMarzo; Colin J Henderson; Jessica L Hicks; Bernard Kwabi-Addo; William G Nelson
Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose.
PloS one 2011;6(10):e25707.
2010: Rachel Young; C Roland Wolf; Ken Brown; John D Hayes; C Bruce A Whitelaw
Spatial monitoring of toxicity in HMOX-LacZ transgenic mice.
Transgenic research 2010;19(5):897-902.
2010: Rachel Young; John D Hayes; Ken Brown; C Roland Wolf; C Bruce A Whitelaw
Peroxiredoxin gene expression signatures in liver reflect toxic insult.
Assay and drug development technologies 2010;8(4):512-7.
2010: Jillian Ross; Simon M Plummer; Anja Rode; Nico Scheer; Conrad C Bower; Ortwin Vogel; Colin Henderson; C Roland Wolf; Clifford R Elcombe
Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.
Toxicological sciences : an official journal of the Society of Toxicology 2010;116(2):452-66.
2010: Nico Scheer; Jillian Ross; Yury Kapelyukh; Anja Rode; C Roland Wolf
In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(7):1046-53.
2010: G Smith; R Bounds; H Wolf; R J C Steele; F A Carey; C Roland Wolf
Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours - implications for personalised cancer medicine.
British journal of cancer 2010;102(4):693-703.
2010: Xiu Jun Wang; John D Hayes; Larry G Higgins; C Roland Wolf; Albena T Dinkova-Kostova
Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones.
Chemistry & biology 2010;17(1):75-85.
2009: Kenneth J Ritchie; Shaun Walsh; Owen J Sansom; Colin Henderson; C Roland Wolf
Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(49):20859-64.
2009: Katy Schmidt; Catherine Hughes; J A Chudek; Simon R Goodyear; Richard M Aspden; Richard Talbot; Thomas E Gundersen; Rune Blomhoff; Colin Henderson; C Roland Wolf; Cheryll Tickle
Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb.
Molecular and cellular biology 2009;29(10):2716-29.
2009: M J V Wilkie; G Smith; R K Day; Keith Matthews; D Smith; D Blackwood; Ian C Reid; C Roland Wolf
Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy.
The pharmacogenomics journal 2009;9(1):61-70.
2009: Lesley A Stanley; Brian C Horsburgh; Jillian Ross; Nico Scheer; C Roland Wolf
Drug transporters: gatekeepers controlling access of xenobiotics to the cellular interior.
Drug metabolism reviews 2009;41(1):27-65.
2009: Robert D Finn; Colin Henderson; Claire L Scott; C Roland Wolf
Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway.
The Biochemical journal 2009;417(1):43-54.
2008: Jiansheng Zhou; C Roland Wolf; Colin Henderson; Yeping Cai; Philip G Board; Paul S Foster; Dianne C Webb
Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthma.
American journal of respiratory and critical care medicine 2008;178(12):1202-10.
2008: Robert D Finn; Lesley A McLaughlin; Sebastien Ronseaux; Ian Rosewell; J Brian Houston; Colin Henderson; C Roland Wolf
Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.
The Journal of biological chemistry 2008;283(46):31385-93.
2008: Yury Kapelyukh; Mark Paine; Jean-Didier Marechal; Michael J Sutcliffe; C Roland Wolf; Gordon Roberts
Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(10):2136-44.
2008: Nico Scheer; Jillian Ross; Anja Rode; Branko Zevnik; Sandra Niehaves; Nicole Faust; C Roland Wolf
A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.
The Journal of clinical investigation 2008;118(9):3228-39.
2008: Lesley A McLaughlin; Leslie J Dickmann; C Roland Wolf; Colin Henderson
Functional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(7):1322-31.
2008: Jo M Rowe; Claire Welsh; Romi N Pena; C Roland Wolf; Ken Brown; C Bruce A Whitelaw
Illuminating role of CYP1A1 in skin function.
The Journal of investigative dermatology 2008;128(7):1866-8.
2008: Douglas B Vasey; C Roland Wolf; Thomas MacArtney; Ken Brown; C Bruce A Whitelaw
p21-LacZ reporter mice reflect p53-dependent toxic insult.
Toxicology and applied pharmacology 2008;227(3):440-50.
2008: Volker M Arlt; Marie Stiborová; Colin Henderson; Markus Thiemann; Eva Frei; Dagmar Aimová; Rajinder Singh; Gonçalo Gamboa da Costa; Oliver J Schmitz; Peter B Farmer; C Roland Wolf; David H Phillips
Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.
Carcinogenesis 2008;29(3):656-65.
2008: Jean-Didier Marechal; C A Kemp; Gordon Roberts; Mark Paine; C Roland Wolf; Michael J Sutcliffe
Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.
British journal of pharmacology 2008;153 Suppl 1():S82-9.
2008: Marie Stiborová; Volker M Arlt; Colin Henderson; C Roland Wolf; Vera Kotrbová; Michaela Moserová; Jirí Hudecek; David H Phillips; Eva Frei
Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse.
Toxicology and applied pharmacology 2008;226(3):318-27.
2007: Xiu Jun Wang; John D Hayes; Colin Henderson; C Roland Wolf
Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(49):19589-94.
2007: Gilliam Smith; Murray J V Wilkie; Yusuf Y Deeni; Peter M Farr; James Ferguson; C Roland Wolf; Sally H Ibbotson
Melanocortin 1 receptor (MC1R) genotype influences erythemal sensitivity to psoralen-ultraviolet A photochemotherapy.
The British journal of dermatology 2007;157(6):1230-4.
2007: Kenneth J Ritchie; Colin Henderson; Xiu Jun Wang; Olga Vassieva; Dianne Carrie; Peter B Farmer; Margaret Gaskell; Kevin Park; C Roland Wolf
Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane.
Cancer research 2007;67(19):9248-57.
2007: Rachel C Le Pla; Kenneth J Ritchie; Colin Henderson; C Roland Wolf; Chris Harrington; Peter B Farmer
Development of a liquid chromatography-electrospray ionization tandem mass spectrometry method for detecting oxaliplatin-DNA intrastrand cross-links in biological samples.
Chemical research in toxicology 2007;20(8):1177-82.
2007: Robert D Finn; Aileen W McLaren; Dianne Carrie; Colin Henderson; C Roland Wolf
Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: a new model for studying the functions of the P450 system.
The Journal of pharmacology and experimental therapeutics 2007;322(1):40-7.
2007: VANESSA RIBES; Diana M E Otto; Leslie Dickmann; Katy Schmidt; Brigitte Schuhbaur; Colin Henderson; Rune Blomhoff; C Roland Wolf; Cheryll Tickle; Pascal Dollé
Rescue of cytochrome P450 oxidoreductase (Por) mouse mutants reveals functions in vasculogenesis, brain and limb patterning linked to retinoic acid homeostasis.
Developmental biology 2007;303(1):66-81.
2007: Dorota Kostrzewa-Nowak; Mark Paine; Anna Korytowska; Katarzyna Serwatka; Sylwia Piotrowska; C Roland Wolf; Jolanta Tarasiuk
Bioreductive activation of mitoxantrone by NADPH cytochrome P450 reductase. Implications for increasing its ability to inhibit the growth of sensitive and multidrug resistant leukaemia HL60 cells.
Cancer letters 2007;245(1-2):252-62.
2006: Xiu Jun Wang; John D Hayes; C Roland Wolf
Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents.
Cancer research 2006;66(22):10983-94.
2006: Gilliam Smith; Sally H Ibbotson; Muriel M Comrie; Robert S Dawe; AM Bryden; James Ferguson; C Roland Wolf
Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo.
The British journal of dermatology 2006;155(2):275-81.
2006: Jinglei Yu; Mark Paine; Jean-Didier Marechal; Carol A Kemp; Clive J Ward; Simon Brown; Michael J Sutcliffe; Gordon Roberts; Elaine M Rankin; C Roland Wolf
In silico prediction of drug binding to CYP2D6: identification of a new metabolite of metoclopramide.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(8):1386-92.
2006: David M Mutch; Vanessa Crespy; Jennifer Clough; Colin Henderson; Sofiane Lariani; Robert Mansourian; Julie Moulin; C Roland Wolf; Gary Williamson
Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(1):G63-72.
2006: Jean-Didier Marechal; Jinglei Yu; Simon Brown; Iouri Kapelioukh; Elaine M Rankin; C Roland Wolf; Gordon Roberts; Mark Paine; Michael J Sutcliffe
In silico and in vitro screening for inhibition of cytochrome P450 CYP3A4 by comedications commonly used by patients with cancer.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(4):534-8.
2006: Volker M Arlt; Colin Henderson; C Roland Wolf; Heinz H Schmeiser; David H Phillips; Marie Stiborova
Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases.
Cancer letters 2006;234(2):220-31.
2006: Colin Henderson; Georgia J Pass; C Roland Wolf
The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity.
Toxicology letters 2006;162(1):111-7.
2006: Amy Leslie; Arlene Stewart; David U Baty; Dorothy Mechan; Louise McGreavey; Gillian Smith; C Roland Wolf; Mark Sales; Norman Pratt; R J C Steele; Francis A Carey
Chromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utility.
Genes, chromosomes & cancer 2006;45(2):126-35.
2006: Lesley A Stanley; Brian C Horsburgh; Jillian Ross; Nico Scheer; C Roland Wolf
PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.
Drug metabolism reviews 2006;38(3):515-97.
2005: Marie Stiborová; Volker M Arlt; Colin Henderson; C Roland Wolf; Eva Frei; Heinz H Schmeiser; David H Phillips
Molecular mechanism of genotoxicity of the environmental pollutant 3-nitrobenzanthrone.
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 2005;149(2):191-7.
2005: Lesley A McLaughlin; Mark Paine; Carol A Kemp; Jean-Didier Marechal; Jack U Flanagan; Clive J Ward; Michael J Sutcliffe; Gordon Roberts; C Roland Wolf
Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.
The Journal of biological chemistry 2005;280(46):38617-24.
2005: A Conlin; Gilliam Smith; Francis A Carey; C Roland Wolf; R J C Steele
The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma.
Gut 2005;54(9):1283-6.
2005: Dorota Kostrzewa-Nowak; Mark Paine; C Roland Wolf; Jolanta Tarasiuk
The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines.
British journal of cancer 2005;93(1):89-97.
2005: Xiu Jun Wang; Mark Chamberlain; Olga Vassieva; Colin Henderson; C Roland Wolf
Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice.
The Biochemical journal 2005;388(Pt 3):857-67.
2005: Georgia J Pass; Dianne Carrie; Michael Boylan; Sally A Lorimore; Eric Wright; Brian Houston; Colin Henderson; C Roland Wolf
Role of hepatic cytochrome p450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome p450 reductase null mouse.
Cancer research 2005;65(10):4211-7.
2005: Volker M Arlt; Marie Stiborova; Colin Henderson; Martin R Osborne; Christian A Bieler; Eva Frei; Vaclav Martinek; Bruno Sopko; C Roland Wolf; Heinz H Schmeiser; David H Phillips
Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols.
Cancer research 2005;65(7):2644-52.
2005: Sandra J Campbell; Colin Henderson; Daniel Anthony; Duncan Davidson; A John Clark; C Roland Wolf
The murine Cyp1a1 gene is expressed in a restricted spatial and temporal pattern during embryonic development.
The Journal of biological chemistry 2005;280(7):5828-35.
2005: Franck Rencurel; Alasdair Stenhouse; Simon A Hawley; Thomas Friedberg; D Grahame Hardie; Calum Sutherland; C Roland Wolf
AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line.
The Journal of biological chemistry 2005;280(6):4367-73.
2005: Kevin J Spears; Jillian Ross; Alasdair Stenhouse; Clive J Ward; Lay-Beng Goh; C Roland Wolf; Paul Morgan; Andrew Ayrton; Thomas Friedberg
Directional trans-epithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2.
Biochemical pharmacology 2005;69(3):415-23.
2005: Colin Henderson; C Roland Wolf
Disruption of the glutathione transferase pi class genes.
Methods in enzymology 2005;401():116-35.
2004: Ruth C Travis; Michael Churchman; Sarah A Edwards; Gillian Smith; Pia Verkasalo; C Roland Wolf; Helga Wolf; Timothy J Key
No association of polymorphisms in CYP17, CYP19, and HSD17-B1 with plasma estradiol concentrations in 1,090 British women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(12):2282-4.
2004: Faye Turner; Gilliam Smith; Christoph Sachse; Tracy Lightfoot; R Colin Garner; C Roland Wolf; David Forman; D Timothy Bishop; Jennifer H Barrett
Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer.
International journal of cancer. Journal international du cancer 2004;112(2):259-64.
2004: Carol A Kemp; Jack U Flanagan; Annamaria J van Eldik; Jean-Didier Marechal; C Roland Wolf; Gordon Roberts; Mark Paine; Michael J Sutcliffe
Validation of model of cytochrome P450 2D6: an in silico tool for predicting metabolism and inhibition.
Journal of medicinal chemistry 2004;47(22):5340-6.
2004: Jack U Flanagan; Jean-Didier Marechal; Richard Ward; Carol A Kemp; Lesley A McLaughlin; Michael J Sutcliffe; Gordon Roberts; Mark Paine; C Roland Wolf
Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.
The Biochemical journal 2004;380(Pt 2):353-60.
2004: Ruth L Stephen; Mattias Gustafsson; Morag Jarvis; Roger Tatoud; Barry R Marshall; Deborah Knight; Ewa Ehrenborg; Adrian L Harris; C Roland Wolf; Colin N A Palmer
Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines.
Cancer research 2004;64(9):3162-70.
2004: Jolanta Pawłowska; Waldemar Priebe; Mark Paine; C Roland Wolf; Edward Borowski; Jolanta Tarasiuk
The ability of new sugar-modified derivatives of antitumor anthracycline, daunorubicin, to stimulate NAD(P)H oxidation in different cellular oxidoreductase systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase.
Oncology research 2004;14(10):469-74.
2003: Colin Henderson; Diana M E Otto; Aileen W McLaren; Dianne Carrie; C Roland Wolf
Knockout mice in xenobiotic metabolism.
Drug metabolism reviews 2003;35(4):385-92.
2003: Colin Henderson; C Roland Wolf
Transgenic analysis of human drug-metabolizing enzymes: preclinical drug development and toxicology.
Molecular interventions 2003;3(6):331-43.
2003: Diana M E Otto; Colin Henderson; Dianne Carrie; Megan Davey; Thomas Gundersen; Rune Blomhoff; Ralf H Adams; Cheryll Tickle; C Roland Wolf
Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasis.
Molecular and cellular biology 2003;23(17):6103-16.
2003: Amy Leslie; Norman Pratt; Karen Gillespie; Mark Sales; Neil M Kernohan; Gillian Smith; C Roland Wolf; Francis A Carey; R J C Steele
Mutations of APC, K-ras, and p53 are associated with specific chromosomal aberrations in colorectal adenocarcinomas.
Cancer research 2003;63(15):4656-61.
2003: Gilliam Smith; Robert S Dawe; Colin Clark; Alan T Evans; Muriel M Comrie; C Roland Wolf; James Ferguson; Sally H Ibbotson
Quantitative real-time reverse transcription-polymerase chain reaction analysis of drug metabolizing and cytoprotective genes in psoriasis and regulation by ultraviolet radiation.
The Journal of investigative dermatology 2003;121(2):390-8.
2003: Robert Elsby; Neil R Kitteringham; Chris Goldring; Cerys A Lovatt; Mark Chamberlain; Colin Henderson; C Roland Wolf; B Kevin Park
Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi.
The Journal of biological chemistry 2003;278(25):22243-9.
2003: Aldo Gutierrez; Andrew W Munro; Alex Grunau; C Roland Wolf; Nigel S Scrutton; Gordon Roberts
Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding. Relaxation kinetic studies with coenzyme analogues.
European journal of biochemistry / FEBS 2003;270(12):2612-21.
2003: Aldo Gutierrez; Alex Grunau; Mark Paine; Andrew W Munro; C Roland Wolf; Gordon Roberts; Nigel S Scrutton
Electron transfer in human cytochrome P450 reductase.
Biochemical Society transactions 2003;31(Pt 3):497-501.
2003: Gilliam Smith; C Roland Wolf; Yusuf Y Deeni; Robert S Dawe; Alan T Evans; Muriel M Comrie; James Ferguson; Sally H Ibbotson
Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.
Lancet 2003;361(9366):1336-43.
2003: Colin Henderson; Diana M E Otto; Dianne Carrie; Mark Magnuson; Aileen W McLaren; Ian Rosewell; C Roland Wolf
Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.
The Journal of biological chemistry 2003;278(15):13480-6.
2003: Jack U Flanagan; Lesley A McLaughlin; Mark Paine; Michael J Sutcliffe; Gordon Roberts; C Roland Wolf
Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.
The Biochemical journal 2003;370(Pt 3):921-6.
2003: Robert D Finn; Jaswir Basran; Olivier Roitel; C Roland Wolf; Andrew W Munro; Mark Paine; Nigel S Scrutton
Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1.
European journal of biochemistry / FEBS 2003;270(6):1164-75.
2003: Mark Paine; Lesley A McLaughlin; Jack U Flanagan; Carol A Kemp; Michael J Sutcliffe; Gordon Roberts; C Roland Wolf
Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.
The Journal of biological chemistry 2003;278(6):4021-7.
2003: Neil R Kitteringham; Helen Powell; Rosalind E Jenkins; Jane Hamlett; Cerys A Lovatt; Robert Elsby; Colin Henderson; C Roland Wolf; Stephen R Pennington; B Kevin Park
Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol-induced toxicity in the liver.
Proteomics 2003;3(2):191-207.
2003: Jennifer H Barrett; Gilliam Smith; R Waxman; Nigel J Gooderham; Tracy Lightfoot; R Colin Garner; K Augustsson; C Roland Wolf; D Timothy Bishop; David Forman
Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer.
Carcinogenesis 2003;24(2):275-82.
2003: Jolanta Pawłowska; Jolanta Tarasiuk; C Roland Wolf; Mark Paine; Edward Borowski
Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase.
Oncology research 2003;13(5):245-52.
2003: Christoph Sachse; Upinder Bhambra; Gilliam Smith; Tracy Lightfoot; Jennifer H Barrett; Jenna Scollay; R Colin Garner; Alan R Boobis; C Roland Wolf; Nigel J Gooderham
Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.
British journal of clinical pharmacology 2003;55(1):68-76.
2002: Christoph Sachse; Gilliam Smith; Murray J V Wilkie; Jennifer H Barrett; Robin Waxman; frank sullivan; David Forman; D Timothy Bishop; C Roland Wolf
A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer.
Carcinogenesis 2002;23(11):1839-49.
2002: Simon A Chanas; Qing Jiang; Michael McMahon; Gail K McWalter; Lesley I McLellan; Clifford R Elcombe; Colin Henderson; C Roland Wolf; Graeme J Moffat; Ken Itoh; Masayuki Yamamoto; John D Hayes
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.
The Biochemical journal 2002;365(Pt 2):405-16.
2002: Gilliam Smith; Francis A Carey; Julie Beattie; Murray J V Wilkie; Tracy Lightfoot; Jonathan Coxhead; R Colin Garner; R J C Steele; C Roland Wolf
Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(14):9433-8.
2002: Adam Patterson; Kaye J Williams; Rachel L Cowen; Mohammed Jaffar; Brian A Telfer; M Saunders; Rachel E Airley; D Honess; Albert J van der Kogel; C Roland Wolf; Ian J Stratford
Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours.
Gene therapy 2002;9(14):946-54.
2002: Aldo Gutierrez; Mark Paine; C Roland Wolf; Nigel S Scrutton; Gordon Roberts
Relaxation kinetics of cytochrome P450 reductase: internal electron transfer is limited by conformational change and regulated by coenzyme binding.
Biochemistry 2002;41(14):4626-37.
2002: Stephen M Fowler; John M Taylor; Thomas Friedberg; C Roland Wolf; Robert J Riley
CYP3A4 active site volume modification by mutagenesis of leucine 211.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(4):452-6.
2002: C Roland Wolf
The Gerhard Zbinden memorial lecture: application of biochemical and genetic approaches to understanding pathways of chemical toxicity.
Toxicology letters 2002;127(1-3):3-17.
2002: Douglas J A Adamson; David Frew; Roger Tatoud; C Roland Wolf; Colin N A Palmer
Diclofenac antagonizes peroxisome proliferator-activated receptor-gamma signaling.
Molecular pharmacology 2002;61(1):7-12.
2001: Y Y Deeni; Mark Paine; Andrew Ayrton; S E Clarke; RJ Chenery; C Roland Wolf
Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein.
Archives of biochemistry and biophysics 2001;396(1):16-24.
2001: Helen Vosper; Lisa Patel; Tracey L Graham; Guennadi A Khoudoli; A Hill; Colin H Macphee; I Pinto; Stephen A Smith; Keith Suckling; C Roland Wolf; Colin N A Palmer
The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages.
The Journal of biological chemistry 2001;276(47):44258-65.
2001: Mark Paine; S Ayivor; Alastair Munro; P Tsan; Lu-Yun Lian; Gordon Roberts; C Roland Wolf
Role of the conserved phenylalanine 181 of NADPH-cytochrome P450 oxidoreductase in FMN binding and catalytic activity.
Biochemistry 2001;40(45):13439-47.
2001: S Ding; Mark Chamberlain; A McLaren; L Goh; I Duncan; C Roland Wolf
Cross-talk between signalling pathways and the multidrug resistant protein MDR-1.
British journal of cancer 2001;85(8):1175-84.
2001: S Ding; Denggao Yao; Yusuf Y Deeni; Brian Burchell; C Roland Wolf; Thomas Friedberg
Human NADPH-P450 oxidoreductase modulates the level of cytochrome P450 CYP2D6 holoprotein via haem oxygenase-dependent and -independent pathways.
The Biochemical journal 2001;356(Pt 2):613-9.
2001: Michael McMahon; Ken Itoh; Masayuki Yamamoto; Simon A Chanas; Colin Henderson; Lesley I McLellan; C Roland Wolf; Christophe Cavin; John D Hayes
The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.
Cancer research 2001;61(8):3299-307.
2001: C Roland Wolf
Chemoprevention: increased potential to bear fruit.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):2941-3.
2001: Aldo Gutierrez; Lu-Yun Lian; C Roland Wolf; Nigel S Scrutton; Gordon Roberts
Stopped-flow kinetic studies of flavin reduction in human cytochrome P450 reductase and its component domains.
Biochemistry 2001;40(7):1964-75.
2001: J M Baron; L B Goh; Denggao Yao; C Roland Wolf; Thomas Friedberg
Modulation of P450 CYP3A4-dependent metabolism by P-glycoprotein: implications for P450 phenotyping.
The Journal of pharmacology and experimental therapeutics 2001;296(2):351-8.
2001: O Döhr; Mark Paine; Thomas Friedberg; Gordon Roberts; C Roland Wolf
Engineering of a functional human NADH-dependent cytochrome P450 system.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(1):81-6.
2000: Aldo Gutierrez; O Doehr; Mark Paine; C Roland Wolf; Nigel S Scrutton; Gordon Roberts
Trp-676 facilitates nicotinamide coenzyme exchange in the reductive half-reaction of human cytochrome P450 reductase: properties of the soluble W676H and W676A mutant reductases.
Biochemistry 2000;39(51):15990-9.
2000: Colin Henderson; C Roland Wolf; Neil R Kitteringham; H Powell; Diana M E Otto; B K Park
Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12741-5.
2000: Denggao Yao; S Ding; Brian Burchell; C Roland Wolf; Thomas Friedberg
Detoxication of vinca alkaloids by human P450 CYP3A4-mediated metabolism: implications for the development of drug resistance.
The Journal of pharmacology and experimental therapeutics 2000;294(1):387-95.
2000: Dongtao Ni Li; Albrecht Seidel; Michael P Pritchard; C Roland Wolf; Thomas Friedberg
Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol.
Pharmacogenetics 2000;10(4):343-53.
2000: S M Fowler; Robert J Riley; Michael P Pritchard; Michael J Sutcliffe; Thomas Friedberg; C Roland Wolf
Amino acid 305 determines catalytic center accessibility in CYP3A4.
Biochemistry 2000;39(15):4406-14.
2000: Colin Henderson; A Sahraouei; C Roland Wolf
Cytochrome P450s and chemoprevention.
Biochemical Society transactions 2000;28(2):42-6.
2000: John D Hayes; Simon A Chanas; Colin Henderson; Michael McMahon; C Sun; Graeme J Moffat; C Roland Wolf; Masayuki Yamamoto
The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin.
Biochemical Society transactions 2000;28(2):33-41.
2000: Mark Paine; A P Garner; D Powell; J Sibbald; Mark Sales; Norman Pratt; T Smith; D G Tew; C Roland Wolf
Cloning and characterization of a novel human dual flavin reductase.
The Journal of biological chemistry 2000;275(2):1471-8.
2000: J Pawłowska; Jolanta Tarasiuk; Edward Borowski; Malgorzata Wasowska; Irena Oszczapowicz; C Roland Wolf
The ability of new formamidine sugar-modified derivatives of daunorubicin to stimulate free radical formation in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase and xanthine oxidase.
Acta biochimica Polonica 2000;47(1):141-7.
1999: Mirsada Causevic; C Roland Wolf; Colin N A Palmer
Substitution of a conserved amino acid residue alters the ligand binding properties of peroxisome proliferator activated receptors.
FEBS letters 1999;463(3):205-10.
1999: C S Allardyce; PD McDonagh; Lu-Yun Lian; C Roland Wolf; Gordon Roberts
The role of tyrosine-9 and the C-terminal helix in the catalytic mechanism of Alpha-class glutathione S-transferases.
The Biochemical journal 1999;343 Pt 3():525-31.
1999: Colin N A Palmer; Mattias Gustafsson; H Dobson; Claes von Wachenfeldt; C Roland Wolf
Adaptive responses to fatty acids are mediated by the regulated expression of cytochromes P450.
Biochemical Society transactions 1999;27(4):374-8.
1999: MW Voice; Y Zhang; C Roland Wolf; Brian Burchell; Thomas Friedberg
Effects of human cytochrome b5 on CYP3A4 activity and stability in vivo.
Archives of biochemistry and biophysics 1999;366(1):116-24.
1999: Thomas Friedberg; Michael P Pritchard; M Bandera; SP Hanlon; Denggao Yao; Lesley A McLaughlin; S Ding; Brian Burchell; C Roland Wolf
Merits and limitations of recombinant models for the study of human P450-mediated drug metabolism and toxicity: an intralaboratory comparison.
Drug metabolism reviews 1999;31(2):523-44.
1999: Dongtao Ni Li; Michael P Pritchard; SP Hanlon; Brian Burchell; C Roland Wolf; Thomas Friedberg
Competition between cytochrome P-450 isozymes for NADPH-cytochrome P-450 oxidoreductase affects drug metabolism.
The Journal of pharmacology and experimental therapeutics 1999;289(2):661-7.
1999: A P Garner; Mark Paine; I Rodriguez-Crespo; Edwin C Chinje; Paul R. Ortiz de Montellano; Ian J Stratford; D G Tew; C Roland Wolf
Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents.
Cancer research 1999;59(8):1929-34.
1999: PD McDonagh; David J Judah; John D Hayes; Lu-Yun Lian; GE Neal; C Roland Wolf; Gordon Roberts
Determinants of specificity for aflatoxin B1-8,9-epoxide in alpha-class glutathione S-transferases.
The Biochemical journal 1999;339 ( Pt 1)():95-101.
1999: Q Zhao; S Modi; Gilliam Smith; Mark Paine; PD McDonagh; C Roland Wolf; D Tew; Lu-Yun Lian; Gordon Roberts; H P Driessen
Crystal structure of the FMN-binding domain of human cytochrome P450 reductase at 1.93 A resolution.
Protein science : a publication of the Protein Society 1999;8(2):298-306.
1999: Lesley A McLaughlin; Brian Burchell; M Pritchard; C Roland Wolf; Thomas Friedberg
Treatment of mammalian cells with the endoplasmic reticulum-proliferator compactin strongly induces recombinant and endogenous xenobiotic metabolizing enzymes and 3-hydroxy-3-methylglutaryl-CoA reductase in vitro.
Journal of cell science 1999;112 ( Pt 4)():515-23.
1998: Gilliam Smith; M J Stubbins; L W Harries; C Roland Wolf
Molecular genetics of the human cytochrome P450 monooxygenase superfamily.
Xenobiotica; the fate of foreign compounds in biological systems 1998;28(12):1129-65.
1998: Colin N A Palmer; C Roland Wolf
cis-parinaric acid is a ligand for the human peroxisome proliferator activated receptor gamma: development of a novel spectrophotometric assay for the discovery of PPARgamma ligands.
FEBS letters 1998;431(3):476-80.
1998: Colin N A Palmer; E Axen; V Hughes; C Roland Wolf
The repressor protein, Bm3R1, mediates an adaptive response to toxic fatty acids in Bacillus megaterium.
The Journal of biological chemistry 1998;273(29):18109-16.
1998: C Roland Wolf; C J Henderson
Use of transgenic animals in understanding molecular mechanisms of toxicity.
The Journal of pharmacy and pharmacology 1998;50(6):567-74.
1998: Gilliam Smith; S Modi; I Pillai; Lu-Yun Lian; Michael J Sutcliffe; Michael P Pritchard; Thomas Friedberg; Gordon Roberts; C Roland Wolf
Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.
The Biochemical journal 1998;331 ( Pt 3)():783-92.
1998: Colin Henderson; A G Smith; J Ure; K Brown; E J Bacon; C Roland Wolf
Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(9):5275-80.
1998: Colin Henderson; Aileen W McLaren; Graeme J Moffat; E J Bacon; C Roland Wolf
Pi-class glutathione S-transferase: regulation and function.
Chemico-biological interactions 1998;111-112():69-82.
1998: Nancy E Hopkins; N English; V Hughes; Christopher W Rowley; C Roland Wolf; William L Alworth
Induction of CYP102 (cytochrome P450BM-3) in Bacillus megaterium by 17 beta-estradiol and 4-sec-butylphenol.
Biochemical and biophysical research communications 1998;244(3):868-72.
1998: Michael P Pritchard; M J Glancey; J A Blake; David Gilham; Brian Burchell; C Roland Wolf; Thomas Friedberg
Functional co-expression of CYP2D6 and human NADPH-cytochrome P450 reductase in Escherichia coli.
Pharmacogenetics 1998;8(1):33-42.
1998: C Roland Wolf; Sandra J Campbell; A J Clark; A Smith; J O Bishop; Colin Henderson
The use of transgenic animals to assess the role of metabolism in target organ toxicity.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1998;20():443-53.
1997: S Ding; Denggao Yao; Brian Burchell; C Roland Wolf; Thomas Friedberg
High levels of recombinant CYP3A4 expression in Chinese hamster ovary cells are modulated by coexpressed human P450 reductase and hemin supplementation.
Archives of biochemistry and biophysics 1997;348(2):403-10.
1997: Colin N A Palmer; Mirsada Causevic; C Roland Wolf
Modulation of fatty acid signalling by cytochrome P-450-mediated hydroxylation.
Biochemical Society transactions 1997;25(4):1160-5.
1997: N English; Colin N A Palmer; William L Alworth; L Kang; V Hughes; C Roland Wolf
Fatty acid signals in Bacillus megaterium are attenuated by cytochrome P-450-mediated hydroxylation.
The Biochemical journal 1997;327 ( Pt 2)():363-8.
1997: Michael P Pritchard; R Ossetian; Dongtao Ni Li; C J Henderson; Brian Burchell; C Roland Wolf; Thomas Friedberg
A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1.
Archives of biochemistry and biophysics 1997;345(2):342-54.
1997: C A Smith; M Wadelius; A C Gough; D J Harrison; C Roland Wolf; A Rane
A simplified assay for the arylamine N-acetyltransferase 2 polymorphism validated by phenotyping with isoniazid.
Journal of medical genetics 1997;34(9):758-60.
1997: Igor Barsukov; S Modi; Lu-Yun Lian; Kong Hung SZE; Mark Paine; C Roland Wolf; Gordon Roberts
1H, 15N and 13C NMR resonance assignment, secondary structure and global fold of the FMN-binding domain of human cytochrome P450 reductase.
Journal of biomolecular NMR 1997;10(1):63-75.
1997: Graeme J Moffat; Aileen W McLaren; C Roland Wolf
Transcriptional and post-transcriptional mechanisms can regulate cell-specific expression of the human Pi-class glutathione S-transferase gene.
The Biochemical journal 1997;324 ( Pt 1)():91-5.
1997: S Modi; David Gilham; Michael J Sutcliffe; Lu-Yun Lian; WU Primrose; C Roland Wolf; Gordon Roberts
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a substrate of cytochrome P450 2D6: allosteric effects of NADPH-cytochrome P450 reductase.
Biochemistry 1997;36(15):4461-70.
1997: L W Harries; M J Stubbins; David Forman; G C Howard; C Roland Wolf
Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer.
Carcinogenesis 1997;18(4):641-4.
1997: K A Vallis; John Reglinski; M Garner; M M Bridgeman; C Roland Wolf
Menadione-resistant Chinese hamster ovary cells have an increased capacity for glutathione synthesis.
British journal of cancer 1997;76(7):870-7.
1997: David Gilham; W Cairns; Mark Paine; S Modi; R Poulsom; Gordon Roberts; C Roland Wolf
Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.
Xenobiotica; the fate of foreign compounds in biological systems 1997;27(1):111-25.
1996: J A Blake; M Pritchard; S Ding; G C Smith; Brian Burchell; C Roland Wolf; Thomas Friedberg
Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coli.
FEBS letters 1996;397(2-3):210-4.
1996: M J Stubbins; L W Harries; Gilliam Smith; M H Tarbit; C Roland Wolf
Genetic analysis of the human cytochrome P450 CYP2C9 locus.
Pharmacogenetics 1996;6(5):429-39.
1996: Graeme J Moffat; Aileen W McLaren; C Roland Wolf
Functional characterization of the transcription silencer element located within the human Pi class glutathione S-transferase promoter.
The Journal of biological chemistry 1996;271(34):20740-7.
1996: Ann K Daly; J Brockmöller; F Broly; M Eichelbaum; William Evans; F J Gonzalez; J D Huang; JR Idle; M Ingelman-Sundberg; T Ishizaki; Evelyne Jacqz-Aigrain; U A Meyer; D W Nebert; Vidar M Steen; C Roland Wolf; Uli Zanger
Nomenclature for human CYP2D6 alleles.
Pharmacogenetics 1996;6(3):193-201.
1996: N English; V Hughes; C Roland Wolf
Induction of cytochrome P-450 BM-3 (CYP 102) by non-steroidal anti-inflammatory drugs in Bacillus megaterium.
The Biochemical journal 1996;316 ( Pt 1)():279-83.
1996: S Modi; Mark Paine; Michael J Sutcliffe; Lu-Yun Lian; WU Primrose; C Roland Wolf; Gordon Roberts
A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding.
Biochemistry 1996;35(14):4540-50.
1996: Mark Paine; D Gilham; Gordon Roberts; C Roland Wolf
Functional high level expression of cytochrome P450 CYP2D6 using baculoviral expression systems.
Archives of biochemistry and biophysics 1996;328(1):143-50.
1996: K A Vallis; C Roland Wolf
Relationship between the adaptive response to oxidants and stable menadione-resistance in Chinese hamster ovary cell lines.
Carcinogenesis 1996;17(4):649-54.
1996: Robert Hume; Ann Burchell; B B Allan; C Roland Wolf; R W Kelly; A Hallas; Brian Burchell
The ontogeny of key endoplasmic reticulum proteins in human embryonic and fetal red blood cells.
Blood 1996;87(2):762-70.
1996: Graeme J Moffat; Aileen W McLaren; C Roland Wolf
Sp1-mediated transcriptional activation of the human Pi class glutathione S-transferase promoter.
The Journal of biological chemistry 1996;271(2):1054-60.
1995: Lesley I McLellan; A D Lewis; D J Hall; J D Ansell; C Roland Wolf
Uptake and distribution of N-acetylcysteine in mice: tissue-specific effects on glutathione concentrations.
Carcinogenesis 1995;16(9):2099-106.
1995: S Modi; Lu-Yun Lian; Gordon Roberts; G C Smith; Mark Paine; C Roland Wolf
Structural studies on FMN domain of cytochrome P450 reductase.
Biochemical Society transactions 1995;23(3):476S.
1995: T K Bammler; H Driessen; N Finnstrom; C Roland Wolf
Amino acid differences at positions 10, 11, and 104 explain the profound catalytic differences between two murine pi-class glutathione S-transferases.
Biochemistry 1995;34(28):9000-8.
1995: Ian N H White; F De Matteis; A H Gibbs; C K Lim; C Roland Wolf; C Henderson; L L Smith
Species differences in the covalent binding of [14C]tamoxifen to liver microsomes and the forms of cytochrome P450 involved.
Biochemical pharmacology 1995;49(8):1035-42.
1995: S Ding; B G Lake; Thomas Friedberg; C Roland Wolf
Expression and alternative splicing of the cytochrome P-450 CYP2A7.
The Biochemical journal 1995;306 ( Pt 1)():161-6.
1994: J E Freeman; C Roland Wolf
Evidence against a role for serine 129 in determining murine cytochrome P450 Cyp2e-1 protein levels.
Biochemistry 1994;33(47):13963-6.
1994: N English; V Hughes; C Roland Wolf
Common pathways of cytochrome P450 gene regulation by peroxisome proliferators and barbiturates in Bacillus megaterium ATCC14581.
The Journal of biological chemistry 1994;269(43):26836-41.
1994: G C Smith; D G Tew; C Roland Wolf
Dissection of NADPH-cytochrome P450 oxidoreductase into distinct functional domains.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(18):8710-4.
1994: A L Russell; Colin Henderson; G Smith; C Roland Wolf
Suppression of multi-drug resistance gene expression in the mouse liver by 1,4-bis[2,(3,5-dichloropyridyloxy)]benzene.
International journal of cancer. Journal international du cancer 1994;58(4):550-4.
1994: Colin Henderson; T Bammler; C Roland Wolf
Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney.
Biochimica et biophysica acta 1994;1200(2):182-90.
1994: Graeme J Moffat; Aileen W McLaren; C Roland Wolf
Involvement of Jun and Fos proteins in regulating transcriptional activation of the human pi class glutathione S-transferase gene in multidrug-resistant MCF7 breast cancer cells.
The Journal of biological chemistry 1994;269(23):16397-402.
1994: T K Bammler; C A Smith; C Roland Wolf
Isolation and characterization of two mouse Pi-class glutathione S-transferase genes.
The Biochemical journal 1994;298 ( Pt 2)():385-90.
1994: A C Gough; S Zhong; C Roland Wolf; Nigel K Spurr
Chromosome assignment of the human glutathione S-transferase mu 3 gene (GSTM3) to chromosome 1 by gene specific polymerase chain reaction.
Cytogenetics and cell genetics 1994;65(1-2):111-4.
1994: Christopher Smith; G Smith; C Roland Wolf
Genetic polymorphisms in xenobiotic metabolism.
European journal of cancer (Oxford, England : 1990) 1994;30A(13):1921-35.
1993: G C Smith; J G Kenna; D J Harrison; D Tew; C Roland Wolf
Autoantibodies to hepatic microsomal carboxylesterase in halothane hepatitis.
Lancet 1993;342(8877):963-4.
1993: C J Wareing; Stephen Matthew Black; John D Hayes; C Roland Wolf
Increased levels of alpha-class and pi-class glutathione S-transferases in cell lines resistant to 1-chloro-2,4-dinitrobenzene.
European journal of biochemistry / FEBS 1993;217(2):671-6.
1993: A P Simula; M B Crichton; Stephen Matthew Black; S Pemble; H F Bligh; J D Beggs; C Roland Wolf
Heterologous expression of drug-metabolizing enzymes in cellular and whole animal models.
Toxicology 1993;82(1-3):3-20.
1993: S Zhong; A H Wyllie; D Barnes; C Roland Wolf; N K Spurr
Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer.
Carcinogenesis 1993;14(9):1821-4.
1993: T P Simula; M J Glancey; C Roland Wolf
Human glutathione S-transferase-expressing Salmonella typhimurium tester strains to study the activation/detoxification of mutagenic compounds: studies with halogenated compounds, aromatic amines and aflatoxin B1.
Carcinogenesis 1993;14(7):1371-6.
1993: G Smith; D J Harrison; N East; F Rae; H Wolf; C Roland Wolf
Regulation of cytochrome P450 gene expression in human colon and breast tumour xenografts.
British journal of cancer 1993;68(1):57-63.
1993: S Zhong; N K Spurr; J D Hayes; C Roland Wolf
Deduced amino acid sequence, gene structure and chromosomal location of a novel human class Mu glutathione S-transferase, GSTM4.
The Biochemical journal 1993;291 ( Pt 1)():41-50.
1993: A C Gough; C A Smith; S M Howell; C Roland Wolf; S P Bryant; Nigel K Spurr
Localization of the CYP2D gene locus to human chromosome 22q13.1 by polymerase chain reaction, in situ hybridization, and linkage analysis.
Genomics 1993;15(2):430-2.
1993: G Smith; Colin Henderson; M G Parker; R White; R G Bars; C Roland Wolf
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, an extremely potent modulator of mouse hepatic cytochrome P-450 gene expression.
The Biochemical journal 1993;289 ( Pt 3)():807-13.
1992: S Zhong; C Roland Wolf; Nigel K Spurr
Chromosomal assignment and linkage analysis of the human glutathione S-transferase mu gene (GSTM1) using intron specific polymerase chain reaction.
Human genetics 1992;90(4):435-9.
1992: C A Smith; J E Moss; A C Gough; Nigel K Spurr; C Roland Wolf
Molecular genetic analysis of the cytochrome P450-debrisoquine hydroxylase locus and association with cancer susceptibility.
Environmental health perspectives 1992;98():107-12.
1992: C Roland Wolf; C A Smith; G Smith; A C Gough; S Bryant; Nigel K Spurr; D J Harrison
Molecular genetics of the human cytochrome P450-dependent monooxygenases.
The Tohoku journal of experimental medicine 1992;168(2):73-81.
1992: L A Stanley; J Carmichael; C Roland Wolf
Cytochrome P-450 induction in human lung tumor-derived cell lines. Characterisation and effects of inflammatory mediators.
European journal of biochemistry / FEBS 1992;208(2):521-9.
1992: C Roland Wolf; C A Smith; A C Gough; J E Moss; K A Vallis; G Howard; F J Carey; K Mills; W McNee; J Carmichael
Relationship between the debrisoquine hydroxylase polymorphism and cancer susceptibility.
Carcinogenesis 1992;13(6):1035-8.
1992: A Bartoszek; C Roland Wolf
Enhancement of doxorubicin toxicity following activation by NADPH cytochrome P450 reductase.
Biochemical pharmacology 1992;43(7):1449-57.
1992: J E Freeman; David Stirling; A L Russell; C Roland Wolf
cDNA sequence, deduced amino acid sequence, predicted gene structure and chemical regulation of mouse Cyp2e1.
The Biochemical journal 1992;281 ( Pt 3)():689-95.
1992: Stephen Matthew Black; S Ellard; J M Parry; C Roland Wolf
Increased sterigmatocystin-induced mutation frequency in Saccharomyces cerevisiae expressing cytochrome P450 CYP2B1.
Biochemical pharmacology 1992;43(2):374-6.
1992: Colin Henderson; A L Russell; J A Allan; C Roland Wolf
Sexual differentiation and regulation of cytochrome P-450 CYP2C7.
Biochimica et biophysica acta 1992;1118(2):99-106.
1992: H F Bligh; C Roland Wolf; G Smith; J D Beggs
Production of cytochrome P450 reductase yeast-rat hybrid proteins in Saccharomyces cerevisiae.
Gene 1992;110(1):33-9.
1991: J S Miles; J E Moss; B A Taylor; B Burchell; C Roland Wolf
Mapping genes encoding drug-metabolizing enzymes in recombinant inbred mice.
Genomics 1991;11(2):309-16.
1991: Colin Henderson; C Roland Wolf
Evidence that the androgen receptor mediates sexual differentiation of mouse renal cytochrome P450 expression.
The Biochemical journal 1991;278 ( Pt 2)():499-503.
1991: L A Stanley; D J Adams; F R Balkwill; D Griffin; C Roland Wolf
Differential effects of recombinant interferon alpha on constitutive and inducible cytochrome P450 isozymes in mouse liver.
Biochemical pharmacology 1991;42(2):311-20.
1991: C Roland Wolf; J E Moss; J S Miles; A C Gough; Nigel K Spurr
Prediction of debrisoquine phenotype.
Lancet 1991;337(8741):623.
1991: M Moorghen; J Cairns; Lesley Forrester; John D Hayes; A Hall; A R Cattan; C Roland Wolf; Adrian L Harris
Enhanced expression of glutathione S-transferases in colorectal carcinoma compared to non-neoplastic mucosa.
Carcinogenesis 1991;12(1):13-7.
1991: C Roland Wolf
Individuality in cytochrome P450 expression and its association with the nephrotoxic and carcinogenic effects of chemicals.
IARC scientific publications 1991;(115):281-7.
1991: Stephen Matthew Black; C Roland Wolf
The role of glutathione-dependent enzymes in drug resistance.
Pharmacology & therapeutics 1991;51(1):139-54.
1990: H F Bligh; A Bartoszek; C N Robson; Ian D Hickson; C B Kasper; J D Beggs; C Roland Wolf
Activation of mitomycin C by NADPH:cytochrome P-450 reductase.
Cancer research 1990;50(24):7789-92.
1990: C Roland Wolf; J E Moss; J S Miles; A C Gough; Nigel K Spurr
Detection of debrisoquine hydroxylation phenotypes.
Lancet 1990;336(8728):1452-3.
1990: Lesley Forrester; John D Hayes; R Millis; D Barnes; Adrian L Harris; J J Schlager; Garth Powis; C Roland Wolf
Expression of glutathione S-transferases and cytochrome P450 in normal and tumor breast tissue.
Carcinogenesis 1990;11(12):2163-70.
1990: Lesley Forrester; GE Neal; David J Judah; M J Glancey; C Roland Wolf
Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B1 metabolism in human liver.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8306-10.
1990: A C Gough; J S Miles; Nigel K Spurr; J E Moss; A Gaedigk; M Eichelbaum; C Roland Wolf
Identification of the primary gene defect at the cytochrome P450 CYP2D locus.
Nature 1990;347(6295):773-6.
1990: J S Miles; J E Moss; Richard Meehan; C Roland Wolf
Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7.
Genomics 1990;7(3):445-8.
1990: Stephen Matthew Black; J D Beggs; John D Hayes; A Bartoszek; M Muramatsu; M Sakai; C Roland Wolf
Expression of human glutathione S-transferases in Saccharomyces cerevisiae confers resistance to the anticancer drugs adriamycin and chlorambucil.
The Biochemical journal 1990;268(2):309-15.
1990: J S Miles; Aileen W McLaren; Lesley Forrester; M J Glancey; M A Lang; C Roland Wolf
Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity.
The Biochemical journal 1990;267(2):365-71.
1990: S E Ball; Lesley Forrester; C Roland Wolf; David J Back
Differences in the cytochrome P-450 isoenzymes involved in the 2-hydroxylation of oestradiol and 17 alpha-ethinyloestradiol. Relative activities of rat and human liver enzymes.
The Biochemical journal 1990;267(1):221-6.
1990: Colin Henderson; A R Scott; C S Yang; C Roland Wolf
Testosterone-mediated regulation of mouse renal cytochrome P-450 isoenzymes.
The Biochemical journal 1990;266(3):675-81.
1990: A Forbes Howie; Lesley Forrester; M J Glancey; J J Schlager; Garth Powis; Geoffrey J Beckett; John D Hayes; C Roland Wolf
Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues.
Carcinogenesis 1990;11(3):451-8.
1990: C Roland Wolf; J S Miles; A Gough; N K Spurr
Molecular genetics of the human cytochrome P-450 system.
Biochemical Society transactions 1990;18(1):21-4.
1990: J S Miles; Aileen W McLaren; F J Gonzalez; C Roland Wolf
Alternative splicing in the human cytochrome P450IIB6 gene: use of a cryptic exon within intron 3 and splice acceptor site within exon 4.
Nucleic acids research 1990;18(1):189.
1989: Stephen Matthew Black; S Ellard; Richard Meehan; J M Parry; M Adesnik; J D Beggs; C Roland Wolf
The expression of cytochrome P450IIB1 in Saccharomyces cerevisiae results in an increased mutation frequency when exposed to cyclophosphamide.
Carcinogenesis 1989;10(11):2139-43.
1989: J S Miles; Aileen W McLaren; C Roland Wolf
Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages.
Nucleic acids research 1989;17(20):8241-55.
1989: J S Miles; C Roland Wolf
Principles of DNA cloning.
BMJ (Clinical research ed.) 1989;299(6706):1019-22.
1989: P C Hayes; C Roland Wolf; John D Hayes
Blotting techniques for the study of DNA, RNA, and proteins.
BMJ (Clinical research ed.) 1989;299(6705):965-8.
1989: A D Lewis; Lesley Forrester; John D Hayes; C J Wareing; J Carmichael; Adrian L Harris; M Mooghen; C Roland Wolf
Glutathione S-transferase isoenzymes in human tumours and tumour derived cell lines.
British journal of cancer 1989;60(3):327-31.
1989: A C Gough; Nigel K Spurr; Richard Meehan; J S Miles; C Roland Wolf
An XmnI RFLP detected with a cDNA probe for the CYP2C gene locus on chromosome 10.
Nucleic acids research 1989;17(11):4426.
1989: J S Miles; W Bickmore; J D Brook; Aileen W McLaren; R Meehan; C Roland Wolf
Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity.
Nucleic acids research 1989;17(8):2907-17.
1988: A D Lewis; Ian D Hickson; C N Robson; Adrian L Harris; John D Hayes; S A Griffiths; Margaret M Manson; A E Hall; J E Moss; C Roland Wolf
Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8511-5.
1988: J Carmichael; Lesley Forrester; A D Lewis; John D Hayes; P C Hayes; C Roland Wolf
Glutathione S-transferase isoenzymes and glutathione peroxidase activity in normal and tumour samples from human lung.
Carcinogenesis 1988;9(9):1617-21.
1988: J S Miles; Nigel K Spurr; A C Gough; T Jowett; Aileen W McLaren; J D Brook; C Roland Wolf
A novel human cytochrome P450 gene (P450IIB): chromosomal localization and evidence for alternative splicing.
Nucleic acids research 1988;16(13):5783-95.
1988: C Roland Wolf; J S Miles; S Seilman; M D Burke; B N Rospendowski; K Kelly; W E Smith
Evidence that the catalytic differences of two structurally homologous forms of cytochrome P-450 relate to their heme environment.
Biochemistry 1988;27(5):1597-603.
1987: Craig N Robson; A D Lewis; C Roland Wolf; John D Hayes; A Hall; Stephen J Proctor; Adrian L Harris; Ian D Hickson
Reduced levels of drug-induced DNA cross-linking in nitrogen mustard-resistant Chinese hamster ovary cells expressing elevated glutathione S-transferase activity.
Cancer research 1987;47(22):6022-7.
1987: H G Mandel; Margaret M Manson; David J Judah; J L Simpson; J A Green; Lesley Forrester; C Roland Wolf; GE Neal
Metabolic basis for the protective effect of the antioxidant ethoxyquin on aflatoxin B1 hepatocarcinogenesis in the rat.
Cancer research 1987;47(19):5218-23.
1987: C Roland Wolf; A D Lewis; J Carmichael; D J Adams; S G Allan; D J Ansell
The role of glutathione in determining the response of normal and tumor cells to anticancer drugs.
Biochemical Society transactions 1987;15(4):728-30.