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John Wolfe

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TOP 3
Raquel M Walton; Thomas Parmentier; John H Wolfe
Postnatal neural precursor cell regions in the rostral subventricular zone, hippocampal subgranular zone and cerebellum of the dog (Canis lupus familiaris).
Janlee A Jensen; Angela M Mexas; Jessica H Bagel; Angela K Brice; Sea Young Yoon; John H Wolfe
Hypervitaminosis D in Guinea Pigs with α-Mannosidosis.
Michael K Parente; Ramona Rozen; Cassia N Cearley; John H Wolfe
Dysregulation of gene expression in a lysosomal storage disease varies between brain regions implicating unexpected mechanisms of neuropathology.

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All Publications

2013: Raquel M Walton; Thomas Parmentier; John H Wolfe
Postnatal neural precursor cell regions in the rostral subventricular zone, hippocampal subgranular zone and cerebellum of the dog (Canis lupus familiaris).
Histochemistry and cell biology 2013;139(3):415-29.
2013: Janlee A Jensen; Angela M Mexas; Jessica H Bagel; Angela K Brice; Sea Young Yoon; John H Wolfe
Hypervitaminosis D in Guinea Pigs with α-Mannosidosis.
Comparative medicine 2013;63(2):156-62.
2012: Michael K Parente; Ramona Rozen; Cassia N Cearley; John H Wolfe
Dysregulation of gene expression in a lysosomal storage disease varies between brain regions implicating unexpected mechanisms of neuropathology.
PloS one 2012;7(3):e32419.
2011: Luk Vandenberghe; Lili Wang; James M Wilson; John H Wolfe; Ru Xiao; Roberto Calcedo; Michael J Castle; Cassia N Cearley; Rebecca Grant; Alexandra C Maguire; Albert M Maguire; Peter Bell; Jean Bennett
Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey.
Science translational medicine 2011;3(88):88ra54.
2010: Sergey Magnitsky; Charles H Vite; Edward Delikatny; Stephen Pickup; Suzanne Wehrli; John H Wolfe; harish poptani
Magnetic resonance spectroscopy of the occipital cortex and the cerebellar vermis distinguishes individual cats affected with alpha-mannosidosis from normal cats.
NMR in biomedicine 2010;23(1):74-9.
2009: T Husain; Marco A Passini; Michael K Parente; Nigel W Fraser; John H Wolfe
Long-term AAV vector gene and protein expression in mouse brain from a small pan-cellular promoter is similar to neural cell promoters.
Gene therapy 2009;16(7):927-32.
2008: Sergey Magnitsky; Raquel M Walton; John H Wolfe; harish poptani
Magnetic resonance imaging detects differences in migration between primary and immortalized neural stem cells.
Academic radiology 2008;15(10):1269-81.
2008: Cassia N Cearley; Luk Vandenberghe; Michael K Parente; Erin R Carnish; James M Wilson; John H Wolfe
Expanded repertoire of AAV vector serotypes mediate unique patterns of transduction in mouse brain.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(10):1710-8.
2008: Raquel M Walton; John H Wolfe
In vitro growth and differentiation of canine olfactory bulb-derived neural progenitor cells under variable culture conditions.
Journal of neuroscience methods 2008;169(1):158-67.
2008: Charles H Vite; Sergey Magnitsky; David O Aleman; P O'Donnell; K Cullen; W Ding; Stephen Pickup; John H Wolfe; harish poptani
Apparent diffusion coefficient reveals gray and white matter disease, and T2 mapping detects white matter disease in the brain in feline alpha-mannosidosis.
AJNR. American journal of neuroradiology 2008;29(2):308-13.
2007: Raquel M Walton; John H Wolfe
Abnormalities in neural progenitor cells in a dog model of lysosomal storage disease.
Journal of neuropathology and experimental neurology 2007;66(8):760-9.
2007: Sergey Magnitsky; Raquel M Walton; John H Wolfe; harish poptani
Magnetic resonance imaging as a tool for monitoring stem cell migration.
Neuro-degenerative diseases 2007;4(4):314-21.
2007: Bradford Berges; John H Wolfe; Nigel W Fraser
Transduction of brain by herpes simplex virus vectors.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(1):20-9.
2006: Deborah J Watson; Raquel M Walton; Sergey Magnitsky; Jeff W M Bulte; harish poptani; John H Wolfe
Structure-specific patterns of neural stem cell engraftment after transplantation in the adult mouse brain.
Human gene therapy 2006;17(7):693-704.
2006: Brian A Karolewski; John H Wolfe
Genetic correction of the fetal brain increases the lifespan of mice with the severe multisystemic disease mucopolysaccharidosis type VII.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(1):14-24.
2006: Li-Bin Li; Shuy-Vang Toan; Olga Zelenaia; Deborah J Watson; John H Wolfe; Jeffrey rothstein; Michael B Robinson
Regulation of astrocytic glutamate transporter expression by Akt: evidence for a selective transcriptional effect on the GLT-1/EAAT2 subtype.
Journal of neurochemistry 2006;97(3):759-71.
2006: Bradford Berges; Srikanth Yellayi; Brian A Karolewski; Richard R Miselis; John H Wolfe; Nigel W Fraser
Widespread correction of lysosomal storage in the mucopolysaccharidosis type VII mouse brain with a herpes simplex virus type 1 vector expressing beta-glucuronidase.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;13(5):859-69.
2005: Bradford Berges; John H Wolfe; Nigel W Fraser
Stable levels of long-term transgene expression driven by the latency-associated transcript promoter in a herpes simplex virus type 1 vector.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(6):1111-9.
2005: Sergey Magnitsky; Deborah J Watson; Raquel M Walton; Stephen Pickup; Jeff W M Bulte; John H Wolfe; harish poptani
In vivo and ex vivo MRI detection of localized and disseminated neural stem cell grafts in the mouse brain.
NeuroImage 2005;26(3):744-54.
2005: Charles H Vite; Joseph McGowan; Sumit N Niogi; Marco A Passini; Kenneth J Drobatz; Mark E Haskins; John H Wolfe
Effective gene therapy for an inherited CNS disease in a large animal model.
Annals of neurology 2005;57(3):355-64.
2005: Deborah J Watson; Marco A Passini; John H Wolfe
Transduction of the choroid plexus and ependyma in neonatal mouse brain by vesicular stomatitis virus glycoprotein-pseudotyped lentivirus and adeno-associated virus type 5 vectors.
Human gene therapy 2005;16(1):49-56.
2004: Luca Longhi; Deborah J Watson; Kathryn E Saatman; Hilaire J Thompson; Chen Zhang; Scott Fujimoto; Nicolas C Royo; Deborah Castelbuono; Ramesh Raghupathi; John Q Trojanowski; Virginia M-Y Lee; John H Wolfe; Nino Stocchetti; Tracy K McIntosh
Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice.
Journal of neurotrauma 2004;21(12):1723-36.
2004: Bala T S Susarla; Rebecca P Seal; Olga Zelenaia; Deborah J Watson; John H Wolfe; Susan Amara; Michael B Robinson
Differential regulation of GLAST immunoreactivity and activity by protein kinase C: evidence for modification of amino and carboxyl termini.
Journal of neurochemistry 2004;91(5):1151-63.
2004: Deborah J Watson; Brian A Karolewski; John H Wolfe
Stable gene delivery to CNS cells using lentiviral vectors.
Methods in molecular biology (Clifton, N.J.) 2004;246():413-28.
2004: Marco A Passini; Deborah J Watson; John H Wolfe
Gene delivery to the mouse brain with adeno-associated virus.
Methods in molecular biology (Clifton, N.J.) 2004;246():225-36.
2003: Charles H Vite; Marco A Passini; Mark E Haskins; John H Wolfe
Adeno-associated virus vector-mediated transduction in the cat brain.
Gene therapy 2003;10(22):1874-81.
2003: Brian A Karolewski; Deborah J Watson; Michael K Parente; John H Wolfe
Comparison of transfection conditions for a lentivirus vector produced in large volumes.
Human gene therapy 2003;14(14):1287-96.
2003: Marco A Passini; Deborah J Watson; Charles H Vite; Daniel J Landsburg; Alyson L Feigenbaum; John H Wolfe
Intraventricular brain injection of adeno-associated virus type 1 (AAV1) in neonatal mice results in complementary patterns of neuronal transduction to AAV2 and total long-term correction of storage lesions in the brains of beta-glucuronidase-deficient mice.
Journal of virology 2003;77(12):7034-40.
2003: Deborah J Watson; Luca Longhi; Edward B Lee; Carl T Fulp; Scott Fujimoto; Nicolas C Royo; Marco A Passini; John Q Trojanowski; Virginia M-Y Lee; Tracy K McIntosh; John H Wolfe
Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury.
Journal of neuropathology and experimental neurology 2003;62(4):368-80.
2003: Deborah J Watson; John H Wolfe
Lentiviral vectors for gene transfer to the central nervous system. Applications in lysosomal storage disease animal models.
Methods in molecular medicine 2003;76():383-403.
2002: Gregory G Heuer; Marco A Passini; Kanli Jiang; Michael K Parente; Virginia M-Y Lee; John Q Trojanowski; John H Wolfe
Selective neurodegeneration in murine mucopolysaccharidosis VII is progressive and reversible.
Annals of neurology 2002;52(6):762-70.
2002: Katherine P Ponder; John R Melniczek; Lingfei Xu; Margaret A Weil; Thomas M O'Malley; Patricia A O'Donnell; Van W Knox; Gustavo D Aguirre; Hamutal Mazrier; N Matthew Ellinwood; Meg M Sleeper; Albert M Maguire; Susan W Volk; Robert L Mango; Jean Zweigle; John H Wolfe; Mark E Haskins
Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):13102-7.
2002: R K Prasad Alur; B Foley; Michael K Parente; D K Tobin; Gregory G Heuer; A N Avadhani; JM Pongubala; John H Wolfe
Modification of multiple transcriptional regulatory elements in a Moloney murine leukemia virus gene transfer vector circumvents silencing in fibroblast grafts and increases levels of expression of the transferred enzyme.
Gene therapy 2002;9(17):1146-54.
2002: Marco A Passini; Edward B Lee; Gregory G Heuer; John H Wolfe
Distribution of a lysosomal enzyme in the adult brain by axonal transport and by cells of the rostral migratory stream.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(15):6437-46.
2002: Makoto Nagano; Deborah J Watson; Buom-Yong Ryu; John H Wolfe; Ralph L Brinster
Lentiviral vector transduction of male germ line stem cells in mice.
FEBS letters 2002;524(1-3):111-5.
2002: Deborah J Watson; Gary P Kobinger; Marco A Passini; James M Wilson; John H Wolfe
Targeted transduction patterns in the mouse brain by lentivirus vectors pseudotyped with VSV, Ebola, Mokola, LCMV, or MuLV envelope proteins.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(5 Pt 1):528-37.
2002: Lingfei Xu; Mark E Haskins; John R Melniczek; Cuihua Gao; Margaret A Weil; Thomas M O'Malley; Patricia A O'Donnell; Hamutal Mazrier; N Matthew Ellinwood; Jean Zweigle; John H Wolfe; Katherine P Ponder
Transduction of hepatocytes after neonatal delivery of a Moloney murine leukemia virus based retroviral vector results in long-term expression of beta-glucuronidase in mucopolysaccharidosis VII dogs.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(2):141-53.
2001: Marco A Passini; John H Wolfe
Widespread gene delivery and structure-specific patterns of expression in the brain after intraventricular injections of neonatal mice with an adeno-associated virus vector.
Journal of virology 2001;75(24):12382-92.
2001: Charles H Vite; Joseph McGowan; K G Braund; Kenneth J Drobatz; J D Glickson; John H Wolfe; Mark E Haskins
Histopathology, electrodiagnostic testing, and magnetic resonance imaging show significant peripheral and central nervous system myelin abnormalities in the cat model of alpha-mannosidosis.
Journal of neuropathology and experimental neurology 2001;60(8):817-28.
2001: Margret L Casal; John H Wolfe
In utero transplantation of fetal liver cells in the mucopolysaccharidosis type VII mouse results in low-level chimerism, but overexpression of beta-glucuronidase can delay onset of clinical signs.
Blood 2001;97(6):1625-34.
2001: Gregory G Heuer; A F Skorupa; R K Prasad Alur; Kanli Jiang; John H Wolfe
Accumulation of abnormal amounts of glycosaminoglycans in murine mucopolysaccharidosis type VII neural progenitor cells does not alter the growth rate or efficiency of differentiation into neurons.
Molecular and cellular neurosciences 2001;17(1):167-78.
2000: H Sun; John H Wolfe
Characterization of an unusual variant mRNA of human lysosomal alpha-mannosidase.
Experimental & molecular medicine 2000;32(4):187-92.
2000: John H Wolfe; M S Sands; Noam Y Harel; Margaret A Weil; Michael K Parente; A C Polesky; J J Reilly; Christopher W Hasson; S Weimelt; Mark E Haskins
Gene transfer of low levels of beta-glucuronidase corrects hepatic lysosomal storage in a large animal model of mucopolysaccharidosis VII.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(6):552-61.
2000: J Zhu; W Kang; John H Wolfe; Nigel W Fraser
Significantly increased expression of beta-glucuronidase in the central nervous system of mucopolysaccharidosis type VII mice from the latency-associated transcript promoter in a nonpathogenic herpes simplex virus type 1 vector.
Molecular therapy : the journal of the American Society of Gene Therapy 2000;2(1):82-94.
2000: Margret L Casal; John H Wolfe
Mucopolysaccharidosis type VII in the developing mouse fetus.
Pediatric research 2000;47(6):750-6.
1999: A F Skorupa; Krishna J Fisher; James M Wilson; Michael K Parente; John H Wolfe
Sustained production of beta-glucuronidase from localized sites after AAV vector gene transfer results in widespread distribution of enzyme and reversal of lysosomal storage lesions in a large volume of brain in mucopolysaccharidosis VII mice.
Experimental neurology 1999;160(1):17-27.
1999: Stephen D. Ginsberg; James E Galvin; Virginia M-Y Lee; Lucy B Rorke; dennis dickson; John H Wolfe; M Z Jones; John Q Trojanowski
Accumulation of intracellular amyloid-beta peptide (A beta 1-40) in mucopolysaccharidosis brains.
Journal of neuropathology and experimental neurology 1999;58(8):815-24.
1999: John C Fyfe; Rebeccah Kurzhals; M E Lassaline; Paula S Henthorn; P R Alur; P Wang; John H Wolfe; Urs Giger; Mark E Haskins; Donald F Patterson; H Sun; S Jain; Naoya Yuhki
Molecular basis of feline beta-glucuronidase deficiency: an animal model of mucopolysaccharidosis VII.
Genomics 1999;58(2):121-8.
1999: H Sun; M Yang; Mark E Haskins; Donald F Patterson; John H Wolfe
Retrovirus vector-mediated correction and cross-correction of lysosomal alpha-mannosidase deficiency in human and feline fibroblasts.
Human gene therapy 1999;10(8):1311-9.
1998: Margret L Casal; John H Wolfe
Variant clinical course of mucopolysaccharidosis type VII in two groups of mice carrying the same mutation.
Laboratory investigation; a journal of technical methods and pathology 1998;78(12):1575-81.
1998: J Ray; John H Wolfe; Gustavo D Aguirre; Mark E Haskins
Retroviral cDNA transfer to the RPE: stable expression and modification of metabolism.
Investigative ophthalmology & visual science 1998;39(9):1658-66.
1998: J Ray; A Bouvet; C DeSanto; John C Fyfe; D Xu; John H Wolfe; Gustavo D Aguirre; Donald F Patterson; Mark E Haskins; Paula S Henthorn
Cloning of the canine beta-glucuronidase cDNA, mutation identification in canine MPS VII, and retroviral vector-mediated correction of MPS VII cells.
Genomics 1998;48(2):248-53.
1997: R M Taylor; John H Wolfe
Decreased lysosomal storage in the adult MPS VII mouse brain in the vicinity of grafts of retroviral vector-corrected fibroblasts secreting high levels of beta-glucuronidase.
Nature medicine 1997;3(7):771-4.
1997: R M Taylor; John H Wolfe
Glycosaminoglycan storage in cultured neonatal murine mucopolysaccharidosis type VII neuroglial cells and correction by beta-glucuronidase gene transfer.
Journal of neurochemistry 1997;68(5):2079-85.
1997: Margret L Casal; John H Wolfe
Amphotropic and ecotropic retroviral vector viruses transduce midgestational murine fetal liver cells in a dual-chambered cocultivation system.
Gene therapy 1997;4(1):39-44.
1996: John H Wolfe; C E Martin; S L Deshmane; J J Reilly; Santosh kesari; Nigel W Fraser
Increased susceptibility to the pathogenic effects of wild-type and recombinant herpesviruses in MPS VII mice compared to normal siblings.
Journal of neurovirology 1996;2(6):417-22.
1996: M K Parente; John H Wolfe
Production of increased titer retrovirus vectors from stable producer cell lines by superinfection and concentration.
Gene therapy 1996;3(9):756-60.
1996: B F Smith; H Stedman; Y Rajpurohit; Paula S Henthorn; John H Wolfe; Donald F Patterson; Urs Giger
Molecular basis of canine muscle type phosphofructokinase deficiency.
The Journal of biological chemistry 1996;271(33):20070-4.
1996: B F Smith; Paula S Henthorn; Y Rajpurohit; H Stedman; John H Wolfe; Donald F Patterson; Urs Giger
A cDNA encoding canine muscle-type phosphofructokinase.
Gene 1996;168(2):275-6.
1995: S L Deshmane; Tibor Valyi-Nagy; Timothy M Block; J Maggioncalda; John H Wolfe; A Dillner; Nigel W Fraser
An HSV-1 containing the rat beta-glucuronidase cDNA inserted within the LAT gene is less efficient than the parental strain at establishing a transcriptionally active state during latency in neurons.
Gene therapy 1995;2(3):209-17.
1995: John H Wolfe; J W Kyle; M S Sands; William S Sly; D G Markowitz; M K Parente
High level expression and export of beta-glucuronidase from murine mucopolysaccharidosis VII cells corrected by a double-copy retrovirus vector.
Gene therapy 1995;2(1):70-8.
1994: R M Taylor; John H Wolfe
Cross-correction of beta-glucuronidase deficiency by retroviral vector-mediated gene transfer.
Experimental cell research 1994;214(2):606-13.
1994: John H Wolfe; R M Taylor; M S Sands; M E Haskins; Donald F Patterson; E Y Snyder
Mucopolysaccharidosis type VII as a model system for gene transfer to the central nervous system.
Gene therapy 1994;1 Suppl 1():S55.
1993: Jane E Barker; John H Wolfe; L B Rowe; EH Birkenmeier
Advantages of gradient vs. 5-fluorouracil enrichment of stem cells for retroviral-mediated gene transfer.
Experimental hematology 1993;21(1):47-54.
1992: John H Wolfe; M S Sands; Jane E Barker; Babette Gwynn; L B Rowe; Carole Vogler; EH Birkenmeier
Reversal of pathology in murine mucopolysaccharidosis type VII by somatic cell gene transfer.
Nature 1992;360(6406):749-53.
1992: John H Wolfe; S L Deshmane; Nigel W Fraser
Herpesvirus vector gene transfer and expression of beta-glucuronidase in the central nervous system of MPS VII mice.
Nature genetics 1992;1(5):379-84.
1990: B F Smith; R K Hoffman; Urs Giger; John H Wolfe
Genes transferred by retroviral vectors into normal and mutant myoblasts in primary cultures are expressed in myotubes.
Molecular and cellular biology 1990;10(6):3268-71.
1990: L E Stramm; John H Wolfe; E H Schuchman; M E Haskins; Donald F Patterson; Gustavo D Aguirre
Beta-glucuronidase mediated pathway essential for retinal pigment epithelial degradation of glycosaminoglycans. Disease expression and in vitro disease correction using retroviral mediated cDNA transfer.
Experimental eye research 1990;50(5):521-32.
1990: John H Wolfe; E H Schuchman; L E Stramm; E A Concaugh; M E Haskins; Gustavo D Aguirre; Donald F Patterson; R J Desnick; Eli Gilboa
Restoration of normal lysosomal function in mucopolysaccharidosis type VII cells by retroviral vector-mediated gene transfer.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):2877-81.