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Michael Wolfe

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Disorders

Alzheimer Disease

Anatomy

Living Beings

Physiology

Signal Transduction

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Publications

TOP 3
Liu Yang; Peacey Eleanor; Dickson John; Donahue Christine P; Zheng Suxin; Varani Gabriele; Wolfe Michael S
Mitoxantrone analogues as ligands for a stem-loop structure of tau pre-mRNA.
Zheng Suxin; Chen Yu; Donahue Christine P; Wolfe Michael S; Varani Gabriele
Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by novantrone (mitoxantrone).
Mowrer Karen R; Wolfe Michael S
Identification of a cis-acting element involved in the regulation of BACE1 mRNA alternative splicing.

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All Publications

2009: Liu Yang; Peacey Eleanor; Dickson John; Donahue Christine P; Zheng Suxin; Varani Gabriele; Wolfe Michael S
Mitoxantrone analogues as ligands for a stem-loop structure of tau pre-mRNA.
Journal of medicinal chemistry 2009;52(21):6523-6.
2009: Zheng Suxin; Chen Yu; Donahue Christine P; Wolfe Michael S; Varani Gabriele
Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by novantrone (mitoxantrone).
Chemistry & biology 2009;16(5):557-66.
2009: Mowrer Karen R; Wolfe Michael S
Identification of a cis-acting element involved in the regulation of BACE1 mRNA alternative splicing.
Journal of neurochemistry 2009;109(4):1008-16.
2009: Wolfe Michael S
Intramembrane-cleaving proteases.
The Journal of biological chemistry 2009;284(21):13969-73.
2009: Golde Todd E; Wolfe Michael S; Greenbaum Doron C
Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins.
Seminars in cell & developmental biology 2009;20(2):225-30.
2009: Wolfe Michael S
Intramembrane proteolysis.
Chemical reviews 2009;109(4):1599-612.
2009: Wolfe Michael S
gamma-Secretase in biology and medicine.
Seminars in cell & developmental biology 2009;20(2):219-24.
2009: Li Huilin; Wolfe Michael S; Selkoe Dennis J
Toward structural elucidation of the gamma-secretase complex.
Structure (London, England : 1993) 2009;17(3):326-34.
2009: Wolfe Michael S
Tau mutations in neurodegenerative diseases.
The Journal of biological chemistry 2009;284(10):6021-5.
2009: Osenkowski Pamela; Li Hua; Ye Wenjuan; Li Dongyang; Aeschbach Lorene; Fraering Patrick C; Wolfe Michael S; Selkoe Dennis J; Li Huilin
Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution.
Journal of molecular biology 2009;385(2):642-52.
2008: Sato Toru; Ananda Kuppanna; Cheng Cathy I; Suh Eric J; Narayanan Saravanakumar; Wolfe Michael S
Distinct pharmacological effects of inhibitors of signal peptide peptidase and gamma-secretase.
The Journal of biological chemistry 2008;283(48):33287-95.
2008: Osenkowski Pamela; Ye Wenjuan; Wang Rong; Wolfe Michael S; Selkoe Dennis J
Direct and potent regulation of gamma-secretase by its lipid microenvironment.
The Journal of biological chemistry 2008;283(33):22529-40.
2008: Wolfe Michael S
Inhibition and modulation of gamma-secretase for Alzheimer's disease.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2008;5(3):391-8.
2008: Mowrer Karen R; Wolfe Michael S
Promotion of BACE1 mRNA alternative splicing reduces amyloid beta-peptide production.
The Journal of biological chemistry 2008;283(27):18694-701.
2008: Kukar Thomas L; Ladd Thomas B; Bann Maralyssa A; Fraering Patrick C; Narlawar Rajeshwar; Maharvi Ghulam M; Healy Brent; Chapman Robert; Welzel Alfred T; Price Robert W; Moore Brenda; Rangachari Vijayaraghavan; Cusack Bernadette; Eriksen Jason; Jansen-West Karen; Verbeeck Christophe; Yager Debra; Eckman Christopher; Ye Wenjuan; Sagi Sarah; Cottrell Barbara A; Torpey Justin; Rosenberry Terrone L; Fauq Abdul; Wolfe Michael S; Schmidt Boris; Walsh Dominic M; Koo Edward H; Golde Todd E
Substrate-targeting gamma-secretase modulators.
Nature 2008;453(7197):925-9.
2008: Wolfe Michael S
Gamma-secretase inhibition and modulation for Alzheimer's disease.
Current Alzheimer research 2008;5(2):158-64.
2008: Cacquevel Matthias; Aeschbach Lorene; Osenkowski Pamela; Li Dongyang; Ye Wenjuan; Wolfe Michael S; Li Huilin; Selkoe Dennis J; Fraering Patrick C
Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease.
Journal of neurochemistry 2008;104(1):210-20.
2008: Wolfe Michael S
Selective amyloid-beta lowering agents.
BMC neuroscience 2008;9 Suppl 2():S4.
2008: Wolfe Michael S
Gamma-secretase: structure, function, and modulation for Alzheimer's disease.
Current topics in medicinal chemistry 2008;8(1):2-8.
2007: Wolfe Michael S
gamma-Secretase modulators.
Current Alzheimer research 2007;4(5):571-3.
2007: Sato Toru; Diehl Thekla S; Narayanan Saravanakumar; Funamoto Satoru; Ihara Yasuo; De Strooper Bart; Steiner Harald; Haass Christian; Wolfe Michael S
Active gamma-secretase complexes contain only one of each component.
The Journal of biological chemistry 2007;282(47):33985-93.
2007: Selkoe Dennis J; Wolfe Michael S
Presenilin: running with scissors in the membrane.
Cell 2007;131(2):215-21.
2007: Wolfe Michael S; Guénette Suzanne Y
APP at a glance.
Journal of cell science 2007;120(Pt 18):3157-61.
2007: Donahue Christine P; Ni Jake; Rozners Eriks; Glicksman Marcie A; Wolfe Michael S
Identification of tau stem loop RNA stabilizers.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 2007;12(6):789-99.
2007: Narayanan Saravanakumar; Sato Toru; Wolfe Michael S
A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis.
The Journal of biological chemistry 2007;282(28):20172-9.
2007: Lieberman Raquel L; Wolfe Michael S
From rhomboid function to structure and back again.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(20):8199-200.
2007: Wolfe Michael S
When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease.
EMBO reports 2007;8(2):136-40.
2007: Lieberman Raquel L; Wolfe Michael S
Membrane-embedded protease poses for photoshoot.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(2):401-2.
2006: Wolfe Michael S
Alzheimer protease hitches a ride.
Nature medicine 2006;12(12):1352-4.
2006: Weng Andrew P; Millholland John M; Yashiro-Ohtani Yumi; Arcangeli Marie Laure; Lau Arthur; Wai Carol; Del Bianco Cristina; Rodriguez Carlos G; Sai Hong; Tobias John; Li Yueming; Wolfe Michael S; Shachaf Cathy; Felsher Dean; Blacklow Stephen C; Pear Warren S; Aster Jon C
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
Genes & development 2006;20(15):2096-109.
2006: Donahue Christine P; Muratore Christina; Wu Jane Y; Kosik Kenneth S; Wolfe Michael S
Stabilization of the tau exon 10 stem loop alters pre-mRNA splicing.
The Journal of biological chemistry 2006;281(33):23302-6.
2006: Sato Toru; Nyborg Andrew C; Iwata Nobuhisa; Diehl Thekla S; Saido Takaomi C; Golde Todd E; Wolfe Michael S
Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs.
Biochemistry 2006;45(28):8649-56.
2006: Wolfe Michael S
The gamma-secretase complex: membrane-embedded proteolytic ensemble.
Biochemistry 2006;45(26):7931-9.
2006: Kornilova Anna Y; Kim Jennifer; Laudon Hanna; Wolfe Michael S
Deducing the transmembrane domain organization of presenilin-1 in gamma-secretase by cysteine disulfide cross-linking.
Biochemistry 2006;45(24):7598-604.
2006: Wolfe Michael S
Shutting down Alzheimer's.
Scientific American 2006;294(5):72-9.
2006: Lazarov Vlado K; Fraering Patrick C; Ye Wenjuan; Wolfe Michael S; Selkoe Dennis J; Li Huilin
Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):6889-94.
2005: Fraering Patrick C; Ye Wenjuan; LaVoie Matthew J; Ostaszewski Beth L; Selkoe Dennis J; Wolfe Michael S
gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site.
The Journal of biological chemistry 2005;280(51):41987-96.
2005: Cowan Jon W; Wang Xiangdong; Guan Ran; He Kai; Jiang Jing; Baumann Gerhard; Black Roy A; Wolfe Michael S; Frank Stuart J
Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage.
The Journal of biological chemistry 2005;280(19):19331-42.
2005: Kornilova Anna Y; Bihel Frédéric; Das Chittaranjan; Wolfe Michael S
The initial substrate-binding site of gamma-secretase is located on presenilin near the active site.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(9):3230-5.
2005: Laras Younes; Quéléver Gilles; Garino Cédrik; Pietrancosta Nicolas; Sheha Mahmoud; Bihel Frédéric; Wolfe Michael S; Kraus Jean-Louis
Substituted thiazolamide coupled to a redox delivery system: a new gamma-secretase inhibitor with enhanced pharmacokinetic profile.
Organic & biomolecular chemistry 2005;3(4):612-8.
2005: Bakshi Pancham; Liao Yung-Feng; Gao Jun; Ni Jake; Stein Ross; Yeh Li-An; Wolfe Michael S
A high-throughput screen to identify inhibitors of amyloid beta-protein precursor processing.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 2005;10(1):1-12.
2005: Urban Sinisa; Wolfe Michael S
Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):1883-8.
2005: Bernardos R L; Lentz S I; Wolfe M S; Raymond P A
Notch-Delta signaling is required for spatial patterning and Müller glia differentiation in the zebrafish retina.
Developmental biology 2005;278(2):381-95.
2004: Bakshi Pancham; Wolfe Michael S
Stereochemical analysis of (hydroxyethyl)urea peptidomimetic inhibitors of gamma-secretase.
Journal of medicinal chemistry 2004;47(26):6485-9.
2004: Liao Yung-Feng; Wang Bo-Jeng; Cheng Hui-Ting; Kuo Lan-Hsin; Wolfe Michael S
Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway.
The Journal of biological chemistry 2004;279(47):49523-32.
2004: Wolfe Michael S; Kopan Raphael
Intramembrane proteolysis: theme and variations.
Science (New York, N.Y.) 2004;305(5687):1119-23.
2004: Fraering Patrick C; Ye Wenjuan; Strub Jean-Marc; Dolios Georgia; LaVoie Matthew J; Ostaszewski Beth L; van Dorsselaer Alain; Wang Rong; Selkoe Dennis J; Wolfe Michael S
Purification and characterization of the human gamma-secretase complex.
Biochemistry 2004;43(30):9774-89.
2004: Bihel Frédéric; Das Chittaranjan; Bowman Michael J; Wolfe Michael S
Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase.
Journal of medicinal chemistry 2004;47(16):3931-3.
2004: van den Brandt Jens; Voss Katrin; Schott Melanie; Hünig Thomas; Wolfe Michael S; Reichardt Holger M
Inhibition of Notch signaling biases rat thymocyte development towards the NK cell lineage.
European journal of immunology 2004;34(5):1405-13.
2004: Eagar Todd N; Tang Qizhi; Wolfe Michael; He Yiping; Pear Warren S; Bluestone Jeffrey A
Notch 1 signaling regulates peripheral T cell activation.
Immunity 2004;20(4):407-15.
2004: Esler William P; Das Chittaranjan; Wolfe Michael S
Probing pockets S2-S4' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimetics.
Bioorganic & medicinal chemistry letters 2004;14(8):1935-8.
2004: Nyborg Andrew C; Kornilova Anna Y; Jansen Karen; Ladd Thomas B; Wolfe Michael S; Golde Todd E
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor.
The Journal of biological chemistry 2004;279(15):15153-60.
2004: Dowthwaite Gary P; Bishop Joanna C; Redman Samantha N; Khan Ilyas M; Rooney Paul; Evans Darrell J R; Haughton Laura; Bayram Zubeyde; Boyer Sam; Thomson Brian; Wolfe Michael S; Archer Charles W
The surface of articular cartilage contains a progenitor cell population.
Journal of cell science 2004;117(Pt 6):889-97.
2004: Fraering Patrick C; LaVoie Matthew J; Ye Wenjuan; Ostaszewski Beth L; Kimberly W Taylor; Selkoe Dennis J; Wolfe Michael S
Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.
Biochemistry 2004;43(2):323-33.
2003: Kimberly W Taylor; Wolfe Michael S
Identity and function of gamma-secretase.
Journal of neuroscience research 2003;74(3):353-60.
2003: Baulac Stephanie; LaVoie Matthew J; Kimberly W Taylor; Strahle Jennifer; Wolfe Michael S; Selkoe Dennis J; Xia Weiming
Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates.
Neurobiology of disease 2003;14(2):194-204.
2003: Schroeter Eric H; Ilagan Ma Xenia G; Brunkan Anne L; Hecimovic Silva; Li Yue-ming; Xu Min; Lewis Huw D; Saxena Meera T; De Strooper Bart; Coonrod Archie; Tomita Taisuke; Iwatsubo Takeshi; Moore Chad L; Goate Alison; Wolfe Michael S; Shearman Mark; Kopan Raphael
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):13075-80.
2003: Das Chittaranjan; Berezovska Oksana; Diehl Thekla S; Genet Cedric; Buldyrev Ilya; Tsai Jui-Yi; Hyman Bradley T; Wolfe Michael S
Designed helical peptides inhibit an intramembrane protease.
Journal of the American Chemical Society 2003;125(39):11794-5.
2003: Adler Scott H; Chiffoleau Elise; Xu Lanwei; Dalton Nicole M; Burg Jennifer M; Wells Andrew D; Wolfe Michael S; Turka Laurence A; Pear Warren S
Notch signaling augments T cell responsiveness by enhancing CD25 expression.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):2896-903.
2003: LaVoie Matthew J; Fraering Patrick C; Ostaszewski Beth L; Ye Wenjuan; Kimberly W Taylor; Wolfe Michael S; Selkoe Dennis J
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin.
The Journal of biological chemistry 2003;278(39):37213-22.
2003: Xia Weiming; Wolfe Michael S
Intramembrane proteolysis by presenilin and presenilin-like proteases.
Journal of cell science 2003;116(Pt 14):2839-44.
2003: Miyamoto Yoshiharu; Maitra Anirban; Ghosh Bidyut; Zechner Ulrich; Argani Pedram; Iacobuzio-Donahue Christine A; Sriuranpong Virote; Iso Tatsuya; Meszoely Ingrid M; Wolfe Michael S; Hruban Ralph H; Ball Douglas W; Schmid Roland M; Leach Steven D
Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis.
Cancer cell 2003;3(6):565-76.
2003: Berezovska Oksana; Ramdya Pavan; Skoch Jesse; Wolfe Michael S; Bacskai Brian J; Hyman Bradley T
Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(11):4560-6.
2003: Campbell William A; Reed Megan L O; Strahle Jennifer; Wolfe Michael S; Xia Weiming
Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase.
Journal of neurochemistry 2003;85(6):1563-74.
2003: Kimberly W Taylor; LaVoie Matthew J; Ostaszewski Beth L; Ye Wenjuan; Wolfe Michael S; Selkoe Dennis J
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6382-7.
2003: Kornilova Anna Y; Das Chittaranjan; Wolfe Michael S
Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications.
The Journal of biological chemistry 2003;278(19):16470-3.
2003: Wolfe Michael S
Gamma-secretase--intramembrane protease with a complex.
Science of aging knowledge environment : SAGE KE 2003;2003(11):PE7.
2003: Kimberly W Taylor; Esler William P; Ye Wenjuan; Ostaszewski Beth L; Gao Jun; Diehl Thekla; Selkoe Dennis J; Wolfe Michael S
Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
Biochemistry 2003;42(1):137-44.
2003: Weng Andrew P; Nam Yunsun; Wolfe Michael S; Pear Warren S; Griffin James D; Blacklow Stephen C; Aster Jon C
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.
Molecular and cellular biology 2003;23(2):655-64.
2003: Micchelli Craig A; Esler William P; Kimberly W Taylor; Jack Christine; Berezovska Oksana; Kornilova Anna; Hyman Bradley T; Perrimon Norbert; Wolfe Michael S
Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):79-81.
2003: Wolfe Michael S
The secretases of Alzheimer's disease.
Current topics in developmental biology 2003;54():233-61.
2002: Wolfe Michael S
APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease.
International immunopharmacology 2002;2(13-14):1919-29.
2002: Wolfe Michael S
Therapeutic strategies for Alzheimer's disease.
Nature reviews. Drug discovery 2002;1(11):859-66.
2002: Kimberly W Taylor; LaVoie Matthew J; Ostaszewski Beth L; Ye Wenjuan; Wolfe Michael S; Selkoe Dennis J
Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation.
The Journal of biological chemistry 2002;277(38):35113-7.
2002: Wolfe Michael S; Esler William P; Das Chittaranjan
Continuing strategies for inhibiting Alzheimer's gamma-secretase.
Journal of molecular neuroscience : MN 2002;19(1-2):83-7.
2002: Wolfe Michael S; Selkoe Dennis J
Biochemistry. Intramembrane proteases--mixing oil and water.
Science (New York, N.Y.) 2002;296(5576):2156-7.
2002: Esler William P; Das Chittaranjan; Campbell William A; Kimberly W Taylor; Kornilova Anna Y; Diehl Thekla S; Ye Wenjuan; Ostaszewski Beth L; Xia Weiming; Selkoe Dennis J; Wolfe Michael S
Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase.
Nature cell biology 2002;4(5):E110-1; author reply E111-2.
2002: Wolfe Michael S
Secretase as a target for Alzheimer's disease.
Current topics in medicinal chemistry 2002;2(4):371-83.
2002: Walsh Dominic M; Klyubin Igor; Fadeeva Julia V; Cullen William K; Anwyl Roger; Wolfe Michael S; Rowan Michael J; Selkoe Dennis J
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.
Nature 2002;416(6880):535-9.
2002: Leissring Malcolm A; Murphy M Paul; Mead Tonya R; Akbari Yama; Sugarman Michael C; Jannatipour Mehrdad; Anliker Brigitte; Müller Ulrike; Saftig Paul; De Strooper Bart; Wolfe Michael S; Golde Todd E; LaFerla Frank M
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4697-702.
2002: Zhang Jimin; Ye Wenjuan; Wang Rong; Wolfe Michael S; Greenberg Barry D; Selkoe Dennis J
Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides.
The Journal of biological chemistry 2002;277(17):15069-75.
2002: Esler William P; Kimberly W Taylor; Ostaszewski Beth L; Ye Wenjuan; Diehl Thekla S; Selkoe Dennis J; Wolfe Michael S
Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2720-5.
2001: Wolfe M S
gamma-Secretase inhibitors as molecular probes of presenilin function.
Journal of molecular neuroscience : MN 2001;17(2):199-204.
2001: Esler W P; Wolfe M S
A portrait of Alzheimer secretases--new features and familiar faces.
Science (New York, N.Y.) 2001;293(5534):1449-54.
2001: Hadland B K; Manley N R; Su D; Longmore G D; Moore C L; Wolfe M S; Schroeter E H; Kopan R
Gamma -secretase inhibitors repress thymocyte development.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7487-91.
2001: Wolfe M S
Secretase targets for Alzheimer's disease: identification and therapeutic potential.
Journal of medicinal chemistry 2001;44(13):2039-60.
2001: Wolfe M S
Presenilin and gamma-secretase: structure meets function.
Journal of neurochemistry 2001;76(6):1615-20.
2001: Jack C; Berezovska O; Wolfe M S; Hyman B T
Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons.
Brain research. Molecular brain research 2001;87(2):166-74.
2001: Wolfe M S; Haass C
The Role of presenilins in gamma-secretase activity.
The Journal of biological chemistry 2001;276(8):5413-6.
2000: Xia W; Ostaszewski B L; Kimberly W T; Rahmati T; Moore C L; Wolfe M S; Selkoe D J
FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Neurobiology of disease 2000;7(6 Pt B):673-81.
2000: Moore C L; Leatherwood D D; Diehl T S; Selkoe D J; Wolfe M S
Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design.
Journal of medicinal chemistry 2000;43(18):3434-42.
2000: Johnson J A; Herring V L; Wolfe M S; Relling M V
CYP1A2 and CYP2D6 4-hydroxylate propranolol and both reactions exhibit racial differences.
The Journal of pharmacology and experimental therapeutics 2000;294(3):1099-105.
2000: Xia W; Ray W J; Ostaszewski B L; Rahmati T; Kimberly W T; Wolfe M S; Zhang J; Goate A M; Selkoe D J
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):9299-304.
2000: Berezovska O; Jack C; McLean P; Aster J C; Hicks C; Xia W; Wolfe M S; Kimberly W T; Weinmaster G; Selkoe D J; Hyman B T
Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Journal of neurochemistry 2000;75(2):583-93.
2000: Esler W P; Kimberly W T; Ostaszewski B L; Diehl T S; Moore C L; Tsai J Y; Rahmati T; Xia W; Selkoe D J; Wolfe M S
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
Nature cell biology 2000;2(7):428-34.
2000: Johnson J A; Akers W S; Herring V L; Wolfe M S; Sullivan J M
Gender differences in labetalol kinetics: importance of determining stereoisomer kinetics for racemic drugs.
Pharmacotherapy 2000;20(6):622-8.
2000: Selkoe D J; Wolfe M S
In search of gamma-secretase: presenilin at the cutting edge.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5690-2.
2000: Kimberly W T; Xia W; Rahmati T; Wolfe M S; Selkoe D J
The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
The Journal of biological chemistry 2000;275(5):3173-8.
2000: Berezovska O; Jack C; McLean P; Aster J C; Hicks C; Xia W; Wolfe M S; Weinmaster G; Selkoe D J; Hyman B T
Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Annals of the New York Academy of Sciences 2000;920():223-6.
2000: Moore C L; Diehl T S; Selkoe D J; Wolfe M S
Toward the characterization and identification of gamma-secretases using transition-state analogue inhibitors.
Annals of the New York Academy of Sciences 2000;920():197-205.
1999: Ray W J; Yao M; Mumm J; Schroeter E H; Saftig P; Wolfe M; Selkoe D J; Kopan R; Goate A M
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.
The Journal of biological chemistry 1999;274(51):36801-7.
1999: Wolfe M S; De Los Angeles J; Miller D D; Xia W; Selkoe D J
Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.
Biochemistry 1999;38(35):11223-30.
1999: De Strooper B; Annaert W; Cupers P; Saftig P; Craessaerts K; Mumm J S; Schroeter E H; Schrijvers V; Wolfe M S; Ray W J; Goate A; Kopan R
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Nature 1999;398(6727):518-22.
1999: Wolfe M S; Xia W; Ostaszewski B L; Diehl T S; Kimberly W T; Selkoe D J
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Nature 1999;398(6727):513-7.
1999: Wolfe M S; Xia W; Moore C L; Leatherwood D D; Ostaszewski B; Rahmati T; Donkor I O; Selkoe D J
Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
Biochemistry 1999;38(15):4720-7.
1998: Wolfe M S
Angiogenesis.
IDrugs : the investigational drugs journal 1998;1(1):22-5.
1998: Wolfe M S; Citron M; Diehl T S; Xia W; Donkor I O; Selkoe D J
A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.
Journal of medicinal chemistry 1998;41(1):6-9.
1995: Wolfe M S; Lee N R; Zatz M
Properties of clock-controlled and constitutive N-acetyltransferases from chick pineal cells.
Brain research 1995;669(1):100-6.
1994: Wolfe M S; Zatz M
Synthesis of heat shock proteins in cultured chick pineal cells.
Brain research 1994;662(1-2):273-7.

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Michael Wolfe

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