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Michael Wolfe

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TOP 3
Michael S Wolfe
Alzheimer's γ-secretase under arrestin.
Eleanor Peacey; Lilia Rodriguez; Yang Liu; Michael S Wolfe
Targeting a pre-mRNA structure with bipartite antisense molecules modulates tau alternative splicing.
Jean-François Fisette; Mihaela-Rita Mihailescu; Daniel R Montagna; Michael S Wolfe
A G-rich element forms a G-quadruplex and regulates BACE1 mRNA alternative splicing.

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All Publications

2013: Michael S Wolfe
Alzheimer's γ-secretase under arrestin.
Nature medicine 2013;19(1):22-4.
2012: Eleanor Peacey; Lilia Rodriguez; Yang Liu; Michael S Wolfe
Targeting a pre-mRNA structure with bipartite antisense molecules modulates tau alternative splicing.
Nucleic acids research 2012;40(19):9836-49.
2012: Jean-François Fisette; Mihaela-Rita Mihailescu; Daniel R Montagna; Michael S Wolfe
A G-rich element forms a G-quadruplex and regulates BACE1 mRNA alternative splicing.
Journal of neurochemistry 2012;121(5):763-73.
2011: Omar Quintero-Monzon; Christina A Cappello; Marty A Fernandez; Amanda J Krzysiak; Morgan M Martin; Pamela Osenkowski; Michael S Wolfe
Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.
Biochemistry 2011;50(42):9023-35.
2011: Xiangdong Wang; Jon W Cowan; Mary Gerhart; Blake R Zelickson; Jing Jiang; Kai He; Michael S Wolfe; Roy A Black; Stuart J Frank
γ-Secretase-mediated growth hormone receptor proteolysis: mapping of the intramembranous cleavage site.
Biochemical and biophysical research communications 2011;408(3):432-6.
2010: Michael S Wolfe
Alzheimer's Disease Drug Discovery--11th International Conference--Targeting Pathological Tau. 27-28 September 2010, Jersey City, NJ, USA.
IDrugs : the investigational drugs journal 2010;13(12):828-9.
2010: Michael S Wolfe
Alzheimer's Disease Drug Discovery--11th International Conference--Promising New Therapeutic Approaches. 27-28 September 2010, Jersey City, NJ, USA.
IDrugs : the investigational drugs journal 2010;13(12):825-7.
2010: Michael S Wolfe
Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteases.
Biological chemistry 2010;391(8):839-47.
2010: Michael S Wolfe; Dennis J Selkoe
Giving Alzheimer's the old one-two.
Cell 2010;142(2):194-6.
2010: C E Augelli-Szafran; H-X Wei; D Lu; J Zhang; Y Gu; T Yang; P Osenkowski; W Ye; Michael S Wolfe
Discovery of notch-sparing gamma-secretase inhibitors.
Current Alzheimer research 2010;7(3):207-9.
2009: Yang Liu; Eleanor Peacey; John Dickson; Christine P Donahue; Suxin Zheng; Gabriele Varani; Michael S Wolfe
Mitoxantrone analogues as ligands for a stem-loop structure of tau pre-mRNA.
Journal of medicinal chemistry 2009;52(21):6523-6.
2009: Suxin Zheng; Yu Chen; Christine P Donahue; Michael S Wolfe; Gabriele Varani
Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by novantrone (mitoxantrone).
Chemistry & biology 2009;16(5):557-66.
2009: Michael S Wolfe
Intramembrane-cleaving proteases.
The Journal of biological chemistry 2009;284(21):13969-73.
2009: Karen R Mowrer; Michael S Wolfe
Identification of a cis-acting element involved in the regulation of BACE1 mRNA alternative splicing.
Journal of neurochemistry 2009;109(4):1008-16.
2009: todd golde; Michael S Wolfe; Doron C Greenbaum
Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins.
Seminars in cell & developmental biology 2009;20(2):225-30.
2009: Michael S Wolfe
Intramembrane proteolysis.
Chemical reviews 2009;109(4):1599-612.
2009: Michael S Wolfe
gamma-Secretase in biology and medicine.
Seminars in cell & developmental biology 2009;20(2):219-24.
2009: Huilin Li; Michael S Wolfe; Dennis J Selkoe
Toward structural elucidation of the gamma-secretase complex.
Structure (London, England : 1993) 2009;17(3):326-34.
2009: Michael S Wolfe
Tau mutations in neurodegenerative diseases.
The Journal of biological chemistry 2009;284(10):6021-5.
2009: Pamela Osenkowski; Huilin Li; Wenjuan Ye; Dongyang Li; Lorene Aeschbach; Patrick C Fraering; Michael S Wolfe; Dennis J Selkoe; Huilin Li
Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution.
Journal of molecular biology 2009;385(2):642-52.
2008: Toru Sato; Kuppanna Ananda; Cathy I Cheng; Eric J Suh; Saravanakumar Narayanan; Michael S Wolfe
Distinct pharmacological effects of inhibitors of signal peptide peptidase and gamma-secretase.
The Journal of biological chemistry 2008;283(48):33287-95.
2008: Pamela Osenkowski; Wenjuan Ye; Rong Wang; Michael S Wolfe; Dennis J Selkoe
Direct and potent regulation of gamma-secretase by its lipid microenvironment.
The Journal of biological chemistry 2008;283(33):22529-40.
2008: Karen R Mowrer; Michael S Wolfe
Promotion of BACE1 mRNA alternative splicing reduces amyloid beta-peptide production.
The Journal of biological chemistry 2008;283(27):18694-701.
2008: Michael S Wolfe
Inhibition and modulation of gamma-secretase for Alzheimer's disease.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2008;5(3):391-8.
2008: Thomas L Kukar; Thomas B Ladd; Maralyssa A Bann; Patrick C Fraering; Rajeshwar Narlawar; Ghulam M Maharvi; Brent Healy; Robert Chapman; Alfred T Welzel; Robert W Price; Brenda Moore; Vijayaraghavan Rangachari; Bernadette Cusack; Jason Eriksen; Karen Jansen-West; Christophe Verbeeck; Debra Yager; Christopher B Eckman; Wenjuan Ye; Sarah A Sagi; Barbara A Cottrell; Justin Torpey; Terrone L Rosenberry; Abdul Fauq; Michael S Wolfe; Boris Schmidt; Dominic M Walsh; Edward H Koo; todd golde
Substrate-targeting gamma-secretase modulators.
Nature 2008;453(7197):925-9.
2008: Michael S Wolfe
Gamma-secretase inhibition and modulation for Alzheimer's disease.
Current Alzheimer research 2008;5(2):158-64.
2008: Michael S Wolfe
Selective amyloid-beta lowering agents.
BMC neuroscience 2008;9 Suppl 2():S4.
2008: Michael S Wolfe
Gamma-secretase: structure, function, and modulation for Alzheimer's disease.
Current topics in medicinal chemistry 2008;8(1):2-8.
2008: Matthias Cacquevel; Lorene Aeschbach; Pamela Osenkowski; Dongyang Li; Wenjuan Ye; Michael S Wolfe; Huilin Li; Dennis J Selkoe; Patrick C Fraering
Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease.
Journal of neurochemistry 2008;104(1):210-20.
2007: Michael S Wolfe
gamma-Secretase modulators.
Current Alzheimer research 2007;4(5):571-3.
2007: Toru Sato; Thekla S Diehl; Saravanakumar Narayanan; Satoru Funamoto; Yasuo Ihara; Bart De Strooper; Harald Steiner; Christian Haass; Michael S Wolfe
Active gamma-secretase complexes contain only one of each component.
The Journal of biological chemistry 2007;282(47):33985-93.
2007: Dennis J Selkoe; Michael S Wolfe
Presenilin: running with scissors in the membrane.
Cell 2007;131(2):215-21.
2007: Michael S Wolfe; Suzanne Y Guénette
APP at a glance.
Journal of cell science 2007;120(Pt 18):3157-61.
2007: Christine P Donahue; Jake Ni; Eriks Rozners; Marcie A Glicksman; Michael S Wolfe
Identification of tau stem loop RNA stabilizers.
Journal of biomolecular screening 2007;12(6):789-99.
2007: Saravanakumar Narayanan; Toru Sato; Michael S Wolfe
A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis.
The Journal of biological chemistry 2007;282(28):20172-9.
2007: Raquel L Lieberman; Michael S Wolfe
From rhomboid function to structure and back again.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(20):8199-200.
2007: Michael S Wolfe
When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease.
EMBO reports 2007;8(2):136-40.
2007: Raquel L Lieberman; Michael S Wolfe
Membrane-embedded protease poses for photoshoot.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(2):401-2.
2006: Michael S Wolfe
Alzheimer protease hitches a ride.
Nature medicine 2006;12(12):1352-4.
2006: Christine P Donahue; Christina Muratore; Jane Y Wu; Kenneth S Kosik; Michael S Wolfe
Stabilization of the tau exon 10 stem loop alters pre-mRNA splicing.
The Journal of biological chemistry 2006;281(33):23302-6.
2006: Andrew P Weng; John M Millholland; Yumi Yashiro-ohtani; Marie Laure Arcangeli; Arthur Lau; Carol Wai; Cristina Del Bianco; Carlos G Rodriguez; Hong Sai; John Tobias; Yueming Li; Michael S Wolfe; Cathy Shachaf; Dean W Felsher; Stephen C Blacklow; Warren S Pear; Jon C Aster
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
Genes & development 2006;20(15):2096-109.
2006: Toru Sato; Andrew C Nyborg; Nobuhisa Iwata; Thekla S Diehl; Takaomi C Saido; todd golde; Michael S Wolfe
Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs.
Biochemistry 2006;45(28):8649-56.
2006: Michael S Wolfe
The gamma-secretase complex: membrane-embedded proteolytic ensemble.
Biochemistry 2006;45(26):7931-9.
2006: Anna Y Kornilova; Jennifer Kim; Hanna Laudon; Michael S Wolfe
Deducing the transmembrane domain organization of presenilin-1 in gamma-secretase by cysteine disulfide cross-linking.
Biochemistry 2006;45(24):7598-604.
2006: Vlado K Lazarov; Patrick C Fraering; Wenjuan Ye; Michael S Wolfe; Dennis J Selkoe; Huilin Li
Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(18):6889-94.
2006: Michael S Wolfe
Shutting down Alzheimer's.
Scientific American 2006;294(5):72-9.
2005: Patrick C Fraering; Wenjuan Ye; Matthew J LaVoie; Beth L Ostaszewski; Dennis J Selkoe; Michael S Wolfe
gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site.
The Journal of biological chemistry 2005;280(51):41987-96.
2005: Jon W Cowan; Xiangdong Wang; Ran Guan; Kai He; Jing Jiang; Gerhard Baumann; Roy A Black; Michael S Wolfe; Stuart J Frank
Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage.
The Journal of biological chemistry 2005;280(19):19331-42.
2005: Anna Y Kornilova; Frederic Bihel; Chittaranjan Das; Michael S Wolfe
The initial substrate-binding site of gamma-secretase is located on presenilin near the active site.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(9):3230-5.
2005: younes laras; Gilles Quéléver; Cédrik Garino; Nicolas Pietrancosta; Mahmoud Sheha; Frederic Bihel; Michael S Wolfe; Jean-Louis Kraus
Substituted thiazolamide coupled to a redox delivery system: a new gamma-secretase inhibitor with enhanced pharmacokinetic profile.
Organic & biomolecular chemistry 2005;3(4):612-8.
2005: Rebecca L. Bernardos; Stephen I Lentz; Michael S Wolfe; Pamela A Raymond
Notch-Delta signaling is required for spatial patterning and Müller glia differentiation in the zebrafish retina.
Developmental biology 2005;278(2):381-95.
2005: Sinisa Urban; Michael S Wolfe
Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):1883-8.
2005: Pancham Bakshi; Yung-Feng Liao; Jun Gao; Jake Ni; Ross Stein; Li-An Yeh; Michael S Wolfe
A high-throughput screen to identify inhibitors of amyloid beta-protein precursor processing.
Journal of biomolecular screening 2005;10(1):1-12.
2004: Pancham Bakshi; Michael S Wolfe
Stereochemical analysis of (hydroxyethyl)urea peptidomimetic inhibitors of gamma-secretase.
Journal of medicinal chemistry 2004;47(26):6485-9.
2004: Yung-Feng Liao; Bo-Jeng Wang; Hui-Ting Cheng; Lan-Hsin Kuo; Michael S Wolfe
Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway.
The Journal of biological chemistry 2004;279(47):49523-32.
2004: Michael S Wolfe; Raphael Kopan
Intramembrane proteolysis: theme and variations.
Science (New York, N.Y.) 2004;305(5687):1119-23.
2004: Patrick C Fraering; Wenjuan Ye; Jean-Marc Strub; Georgia Dolios; Matthew J LaVoie; Beth L Ostaszewski; Alain Van Dorsselaer; Rong Wang; Dennis J Selkoe; Michael S Wolfe
Purification and characterization of the human gamma-secretase complex.
Biochemistry 2004;43(30):9774-89.
2004: Frederic Bihel; Chittaranjan Das; Michael J Bowman; Michael S Wolfe
Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase.
Journal of medicinal chemistry 2004;47(16):3931-3.
2004: Jens van den Brandt; Katrin Voss; Melanie Schott; Thomas Hünig; Michael S Wolfe; Holger M Reichardt
Inhibition of Notch signaling biases rat thymocyte development towards the NK cell lineage.
European journal of immunology 2004;34(5):1405-13.
2004: William P Esler; Chittaranjan Das; Michael S Wolfe
Probing pockets S2-S4' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimetics.
Bioorganic & medicinal chemistry letters 2004;14(8):1935-8.
2004: Andrew C Nyborg; Anna Y Kornilova; Karen Jansen; Thomas B Ladd; Michael S Wolfe; todd golde
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor.
The Journal of biological chemistry 2004;279(15):15153-60.
2004: Todd N Eagar; Qizhi Tang; Michael S Wolfe; Yiping He; Warren S Pear; Jeffrey A Bluestone
Notch 1 signaling regulates peripheral T cell activation.
Immunity 2004;20(4):407-15.
2004: Gary P Dowthwaite; Joanna C Bishop; Samantha N Redman; Ilyas M Khan; Paul Rooney; Darrell J R Evans; Laura Haughton; Zubeyde Bayram; Sam Boyer; Brian Thomson; Michael S Wolfe; Charles W Archer
The surface of articular cartilage contains a progenitor cell population.
Journal of cell science 2004;117(Pt 6):889-97.
2004: Patrick C Fraering; Matthew J LaVoie; Wenjuan Ye; Beth L Ostaszewski; W Taylor Kimberly; Dennis J Selkoe; Michael S Wolfe
Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.
Biochemistry 2004;43(2):323-33.
2003: W Taylor Kimberly; Michael S Wolfe
Identity and function of gamma-secretase.
Journal of neuroscience research 2003;74(3):353-60.
2003: Stephanie Baulac; Matthew J LaVoie; W Taylor Kimberly; Jennifer Strahle; Michael S Wolfe; Dennis J Selkoe; Weiming Xia
Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates.
Neurobiology of disease 2003;14(2):194-204.
2003: Eric H Schroeter; Ma Xenia G Ilagan; Anne L Brunkan; Silva Hecimovic; Yueming Li; Min Xu; Huw D Lewis; Meera T Saxena; Bart De Strooper; Archie Coonrod; Taisuke Tomita; Takeshi Iwatsubo; Chad L Moore; Alison Goate; Michael S Wolfe; Mark S Shearman; Raphael Kopan
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):13075-80.
2003: Chittaranjan Das; Oksana Berezovska; Thekla S Diehl; Cedric Genet; Ilya Buldyrev; Jui-Yi Tsai; Bradley T Hyman; Michael S Wolfe
Designed helical peptides inhibit an intramembrane protease.
Journal of the American Chemical Society 2003;125(39):11794-5.
2003: Matthew J LaVoie; Patrick C Fraering; Beth L Ostaszewski; Wenjuan Ye; W Taylor Kimberly; Michael S Wolfe; Dennis J Selkoe
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin.
The Journal of biological chemistry 2003;278(39):37213-22.
2003: Scott H Adler; Elise Chiffoleau; Lanwei Xu; Nicole M Dalton; Jennifer M Burg; Andrew D Wells; Michael S Wolfe; Laurence A Turka; Warren S Pear
Notch signaling augments T cell responsiveness by enhancing CD25 expression.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):2896-903.
2003: Weiming Xia; Michael S Wolfe
Intramembrane proteolysis by presenilin and presenilin-like proteases.
Journal of cell science 2003;116(Pt 14):2839-44.
2003: Yoshiharu Miyamoto; Anirban Maitra; Bidyut Ghosh; Ulrich Zechner; Pedram Argani; Christine A Iacobuzio-Donahue; Virote Sriuranpong; Tatsuya Iso; Ingrid M Meszoely; Michael S Wolfe; Ralph Hruban; Douglas W Ball; Roland M Schmid; Steven D Leach
Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis.
Cancer cell 2003;3(6):565-76.
2003: Oksana Berezovska; Pavan Ramdya; Jesse Skoch; Michael S Wolfe; Brian J Bacskai; Bradley T Hyman
Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(11):4560-6.
2003: William A Campbell; Megan L O Reed; Jennifer Strahle; Michael S Wolfe; Weiming Xia
Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase.
Journal of neurochemistry 2003;85(6):1563-74.
2003: W Taylor Kimberly; Matthew J LaVoie; Beth L Ostaszewski; Wenjuan Ye; Michael S Wolfe; Dennis J Selkoe
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6382-7.
2003: Anna Y Kornilova; Chittaranjan Das; Michael S Wolfe
Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications.
The Journal of biological chemistry 2003;278(19):16470-3.
2003: Michael S Wolfe
Gamma-secretase--intramembrane protease with a complex.
Science of aging knowledge environment : SAGE KE 2003;2003(11):PE7.
2003: W Taylor Kimberly; William P Esler; Wenjuan Ye; Beth L Ostaszewski; Jun Gao; Thekla S Diehl; Dennis J Selkoe; Michael S Wolfe
Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
Biochemistry 2003;42(1):137-44.
2003: Michael S Wolfe
The secretases of Alzheimer's disease.
Current topics in developmental biology 2003;54():233-61.
2003: Andrew P Weng; Yunsun Nam; Michael S Wolfe; Warren S Pear; James D Griffin; Stephen C Blacklow; Jon C Aster
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.
Molecular and cellular biology 2003;23(2):655-64.
2003: Craig Micchelli; William P Esler; W Taylor Kimberly; Christine Jack; Oksana Berezovska; Anna Y Kornilova; Bradley T Hyman; Norbert Perrimon; Michael S Wolfe
Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):79-81.
2002: Michael S Wolfe
APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease.
International immunopharmacology 2002;2(13-14):1919-29.
2002: Michael S Wolfe
Therapeutic strategies for Alzheimer's disease.
Nature reviews. Drug discovery 2002;1(11):859-66.
2002: W Taylor Kimberly; Matthew J LaVoie; Beth L Ostaszewski; Wenjuan Ye; Michael S Wolfe; Dennis J Selkoe
Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation.
The Journal of biological chemistry 2002;277(38):35113-7.
2002: Michael S Wolfe; William P Esler; Chittaranjan Das
Continuing strategies for inhibiting Alzheimer's gamma-secretase.
Journal of molecular neuroscience : MN 2002;19(1-2):83-7.
2002: Michael S Wolfe; Dennis J Selkoe
Biochemistry. Intramembrane proteases--mixing oil and water.
Science (New York, N.Y.) 2002;296(5576):2156-7.
2002: Jui-Yi Tsai; Michael S Wolfe; Weiming Xia
The search for gamma-secretase and development of inhibitors.
Current medicinal chemistry 2002;9(11):1087-106.
2002: William P Esler; Chittaranjan Das; William A Campbell; W Taylor Kimberly; Anna Y Kornilova; Thekla S Diehl; Wenjuan Ye; Beth L Ostaszewski; Weiming Xia; Dennis J Selkoe; Michael S Wolfe
Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase.
Nature cell biology 2002;4(5):E110-1; author reply E111-2.
2002: Jimin Zhang; Wenjuan Ye; Rong Wang; Michael S Wolfe; Barry D Greenberg; Dennis J Selkoe
Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides.
The Journal of biological chemistry 2002;277(17):15069-75.
2002: Dominic M Walsh; Igor Klyubin; Julia V Fadeeva; William K Cullen; Roger Anwyl; Michael S Wolfe; Michael J Rowan; Dennis J Selkoe
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.
Nature 2002;416(6880):535-9.
2002: Malcolm Leissring; Michael Murphy; Tonya R Mead; Yama Akbari; Michael C Sugarman; Mehrdad Jannatipour; Brigitte Anliker; Ulrike Müller; Paul Saftig; Bart De Strooper; Michael S Wolfe; todd golde; Frank M LaFerla
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4697-702.
2002: Michael S Wolfe
Secretase as a target for Alzheimer's disease.
Current topics in medicinal chemistry 2002;2(4):371-83.
2002: William P Esler; W Taylor Kimberly; Beth L Ostaszewski; Wenjuan Ye; Thekla S Diehl; Dennis J Selkoe; Michael S Wolfe
Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2720-5.
2001: Michael S Wolfe
gamma-Secretase inhibitors as molecular probes of presenilin function.
Journal of molecular neuroscience : MN 2001;17(2):199-204.
2001: William P Esler; Michael S Wolfe
A portrait of Alzheimer secretases--new features and familiar faces.
Science (New York, N.Y.) 2001;293(5534):1449-54.
2001: Michael S Wolfe
Secretase targets for Alzheimer's disease: identification and therapeutic potential.
Journal of medicinal chemistry 2001;44(13):2039-60.
2001: Brandon K Hadland; Nancy R Manley; D Su ; Gregory D Longmore; C L Moore; Michael S Wolfe; Eric H Schroeter; Raphael Kopan
Gamma -secretase inhibitors repress thymocyte development.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7487-91.
2001: Christine Jack; Oksana Berezovska; Michael S Wolfe; Bradley T Hyman
Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons.
Brain research. Molecular brain research 2001;87(2):166-74.
2001: Michael S Wolfe
Presenilin and gamma-secretase: structure meets function.
Journal of neurochemistry 2001;76(6):1615-20.
2001: Michael S Wolfe; Christian Haass
The Role of presenilins in gamma-secretase activity.
The Journal of biological chemistry 2001;276(8):5413-6.
2000: Weiming Xia; Beth L Ostaszewski; W Taylor Kimberly; T Rahmati; CL Moore; Michael S Wolfe; Dennis J Selkoe
FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Neurobiology of disease 2000;7(6 Pt B):673-81.
2000: CL Moore; D D Leatherwood; Thekla S Diehl; Dennis J Selkoe; Michael S Wolfe
Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design.
Journal of medicinal chemistry 2000;43(18):3434-42.
2000: JA Johnson; Vanessa L Herring; Michael S Wolfe; Mary Relling
CYP1A2 and CYP2D6 4-hydroxylate propranolol and both reactions exhibit racial differences.
The Journal of pharmacology and experimental therapeutics 2000;294(3):1099-105.
2000: Weiming Xia; William Ray; Beth L Ostaszewski; T Rahmati; W Taylor Kimberly; Michael S Wolfe; Jimin Zhang; Alison Goate; Dennis J Selkoe
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(16):9299-304.
2000: Oksana Berezovska; Christine Jack; Pamela J McLean; Jon C Aster; C Hicks; Weiming Xia; Michael S Wolfe; W Taylor Kimberly; G Weinmaster; Dennis J Selkoe; Bradley T Hyman
Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Journal of neurochemistry 2000;75(2):583-93.
2000: William P Esler; W Taylor Kimberly; Beth L Ostaszewski; Thekla S Diehl; CL Moore; J Y Tsai; T Rahmati; Weiming Xia; Dennis J Selkoe; Michael S Wolfe
Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.
Nature cell biology 2000;2(7):428-34.
2000: JA Johnson; W S Akers; Vanessa L Herring; Michael S Wolfe; J M Sullivan
Gender differences in labetalol kinetics: importance of determining stereoisomer kinetics for racemic drugs.
Pharmacotherapy 2000;20(6):622-8.
2000: Dennis J Selkoe; Michael S Wolfe
In search of gamma-secretase: presenilin at the cutting edge.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5690-2.
2000: W Taylor Kimberly; Weiming Xia; T Rahmati; Michael S Wolfe; Dennis J Selkoe
The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
The Journal of biological chemistry 2000;275(5):3173-8.
2000: Oksana Berezovska; Christine Jack; Pamela J McLean; Jon C Aster; C Hicks; Weiming Xia; Michael S Wolfe; G Weinmaster; Dennis J Selkoe; Bradley T Hyman
Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Annals of the New York Academy of Sciences 2000;920():223-6.
2000: CL Moore; Thekla S Diehl; Dennis J Selkoe; Michael S Wolfe
Toward the characterization and identification of gamma-secretases using transition-state analogue inhibitors.
Annals of the New York Academy of Sciences 2000;920():197-205.
1999: William Ray; M Yao; Jeff S. Mumm; Eric H Schroeter; Paul Saftig; Michael S Wolfe; Dennis J Selkoe; Raphael Kopan; Alison Goate
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.
The Journal of biological chemistry 1999;274(51):36801-7.
1999: Michael S Wolfe; Joseph E De Los Angeles; Duane D Miller; Weiming Xia; Dennis J Selkoe
Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.
Biochemistry 1999;38(35):11223-30.
1999: Michael S Wolfe; Weiming Xia; CL Moore; D D Leatherwood; Beth L Ostaszewski; T Rahmati; Isaac O Donkor; Dennis J Selkoe
Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
Biochemistry 1999;38(15):4720-7.
1999: Bart De Strooper; Willem ANNAERT; P Cupers; Paul Saftig; Katleen Craessaerts; Jeff S. Mumm; Eric H Schroeter; V Schrijvers; Michael S Wolfe; William Ray; Alison Goate; Raphael Kopan
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Nature 1999;398(6727):518-22.
1999: Michael S Wolfe; Weiming Xia; Beth L Ostaszewski; Thekla S Diehl; W Taylor Kimberly; Dennis J Selkoe
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Nature 1999;398(6727):513-7.
1998: Michael S Wolfe; Martin Citron; Thekla S Diehl; Weiming Xia; Isaac O Donkor; Dennis J Selkoe
A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.
Journal of medicinal chemistry 1998;41(1):6-9.
1995: Michael S Wolfe; N R Lee; M Zatz
Properties of clock-controlled and constitutive N-acetyltransferases from chick pineal cells.
Brain research 1995;669(1):100-6.
1994: Michael S Wolfe; M Zatz
Synthesis of heat shock proteins in cultured chick pineal cells.
Brain research 1994;662(1-2):273-7.