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Claes Wollheim

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Peter Spégel; Susanne G Straub; Claes B Wollheim; Cecilia L F Nagorny; Vladimir V Sharoyko; Geoffrey W G Sharp; Lotta E Andersson; Anders P H Danielsson; Isabel Goehring; Thomas Koeck; Siri Malmgren; Hindrik Mulder
Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release.
Taman Mahdi; Sarheed J Muhammed; Thomas M Reinbothe; Erik Renström; Albert Salehi; Jalal Taneera; Yunzhao Tang; Claes B Wollheim; Enming Zhang; Yuedan Zhou; Peter Almgren; Annika S Axelsson; Anna M Blom; Jonathan Derry; Lena Eliasson; Jonathan Lou S Esguerra; Leif Groop; Ola Hansson; Sonja Hänzelmann; Xingjun Jing; Ulrika Krus; Valeriya Lyssenko; Anders H Rosengren
Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
Nikolaos Perakakis; Natalie Rimmer; Jochen Seufert; Eleni Tsaroucha; Haiyan Wang; Claes B Wollheim; Marcus Alt; Despoina Danassi; Katharina Laubner; Amir E Mehana; Günter Päth
Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box.

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2013: Peter Spégel; Susanne G Straub; Claes B Wollheim; Cecilia L F Nagorny; Vladimir V Sharoyko; Geoffrey W G Sharp; Lotta E Andersson; Anders P H Danielsson; Isabel Goehring; Thomas Koeck; Siri Malmgren; Hindrik Mulder
Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release.
The Biochemical journal 2013;450(3):595-605.
2012: Taman Mahdi; Sarheed J Muhammed; Thomas M Reinbothe; Erik Renström; Albert Salehi; Jalal Taneera; Yunzhao Tang; Claes B Wollheim; Enming Zhang; Yuedan Zhou; Peter Almgren; Annika S Axelsson; Anna M Blom; Jonathan Derry; Lena Eliasson; Jonathan Lou S Esguerra; Leif Groop; Ola Hansson; Sonja Hänzelmann; Xingjun Jing; Ulrika Krus; Valeriya Lyssenko; Anders H Rosengren
Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
Cell metabolism 2012;16(5):625-33.
2012: Nikolaos Perakakis; Natalie Rimmer; Jochen Seufert; Eleni Tsaroucha; Haiyan Wang; Claes B Wollheim; Marcus Alt; Despoina Danassi; Katharina Laubner; Amir E Mehana; Günter Päth
Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box.
Molecular and cellular endocrinology 2012;363(1-2):20-6.
2012: Dmitry Akhmedov; Umberto De Marchi; Claes B Wollheim; Andreas Wiederkehr
Pyruvate dehydrogenase E1α phosphorylation is induced by glucose but does not control metabolism-secretion coupling in INS-1E clonal β-cells.
Biochimica et biophysica acta 2012;1823(10):1815-24.
2012: Domitille Schvartz; Claes B Wollheim; Yannick Brunner; Yohann Couté; Michelangelo Foti; Jean-Charles Sanchez
Improved characterization of the insulin secretory granule proteomes.
Journal of proteomics 2012;75(15):4620-31.
2012: Domitille Schvartz; Claes B Wollheim; Yannick Brunner; Yohann Couté; Jean-Charles Sanchez
Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress.
Molecular & cellular proteomics : MCP 2012;11(8):244-54.
2012: Jalal Taneera; Petter Vikman; Claes B Wollheim; Enming Zhang; Yuedan Zhou; Emma Ahlqvist; Jonathan L S Esguerra; Joao Fadista; Ola Hansson; Xing-Jun Jing; Anna Jonsson; Olle Korsgren; Ulrika Krus; Stefan Lang; Valeriya Lyssenko; Hemang Parikh; Erik Renström; Anders Rosengren; Albert Salehi; Amitabh Sharma; Arvind Soni; Leif Groop
A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.
Cell metabolism 2012;16(1):122-34.
2012: Beatrice T Yang; Tasnim A Dayeh; Xingjun Jing; Clare L Kirkpatrick; Siri Malmgren; Marloes Dekker Nitert; Erik Renström; Petr A Volkov; Claes B Wollheim; Charlotte Ling
Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes.
Molecular endocrinology (Baltimore, Md.) 2012;26(7):1203-12.
2012: Andreas Wiederkehr; Claes B Wollheim
Mitochondrial signals drive insulin secretion in the pancreatic β-cell.
Molecular and cellular endocrinology 2012;353(1-2):128-37.
2012: Sharon Epstein; Clare L Kirkpatrick; Manuel Muñiz; Guillaume A Castillon; Fabrice P A David; Isabelle Riezman; Claes B Wollheim; Howard Riezman
Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells.
Journal of lipid research 2012;53(3):412-20.
2012: Kyu-Sang Park; Andreas Wiederkehr; Claes B Wollheim
Defective mitochondrial function and motility due to mitofusin 1 overexpression in insulin secreting cells.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2012;16(1):71-7.
2011: Fabrizio Thorel; Bernard Thorens; Andreas Wiederkehr; Claes B Wollheim; Simona Chera; Nicolas Damond; Paolo Meda; Pedro L Herrera
Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice.
Diabetes 2011;60(11):2872-82.
2011: Clare L Kirkpatrick; Haiyan Wang; Andreas Wiederkehr; Ildem Akerman; Dmitry Akhmedov; Mathurin Baquié; Jorge Ferrer; Benoit R Gauthier; Hisamitsu Ishihara; Claes B Wollheim
Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress.
The Journal of biological chemistry 2011;286(37):32300-12.
2011: Caroline Bonner; Maria M Byrne; Caoimhín G Concannon; Heiko Dussmann; Angela M Farrelly; Donat Kögel; Hans-Georg König; Marjan Rupnik; Isabelle Virard; Hella Wobser; Claes B Wollheim; Mathurin Baquié; Jochen H M Prehn
Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation.
The Journal of biological chemistry 2011;286(29):25719-28.
2011: Mathurin Baquié; Sophie Borot; Domenico Bosco; Christopher R Cederroth; Nadia Cobo; Carmen M Jimenez Moreno; Julie Kerr Conte; Petra Isabel Lorenzo; Piero Marchetti; Serge Nef; Francois Pattou; Luc St-Onge; Haiyan Wang; Claes B Wollheim; Benoit R Gauthier
The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects {beta}-cells against stress-induced apoptosis.
Human molecular genetics 2011;20(14):2823-33.
2011: Kai Hui Hu He; Jorge Vallejo Ortega; Petra Isabel Lorenzo; Thierry Brun; Carmen M Jimenez Moreno; Deborah Aeberhard; Marion Cornu; Fabrizio Thorel; Asllan Gjinovci; Bernard Thorens; Pedro L Herrera; Paolo Meda; Claes B Wollheim; Benoit R Gauthier
In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.
Diabetes 2011;60(6):1705-15.
2011: Nicole Feldmann; Rafael Martin del Rio; Asllan Gjinovci; Jorge Tamarit-Rodriguez; Claes B Wollheim; Andreas Wiederkehr
Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells.
Molecular and cellular endocrinology 2011;338(1-2):46-57.
2011: Andreas Wiederkehr; Dmitry Akhmedov; Claus W Heizmann; Chikage Mataki; Tullio Pozzan; Kristina Schoonjans; András Spät; Gergo Szanda; Claes B Wollheim
Mitochondrial matrix calcium is an activating signal for hormone secretion.
Cell metabolism 2011;13(5):601-11.
2011: B T Yang; T A Dayeh; C L Kirkpatrick; Jalal Taneera; R Kumar; Leif Groop; Claes B Wollheim; Marloes Dekker Nitert; Charlotte Ling
Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets.
Diabetologia 2011;54(2):360-7.
2010: Seán M Kilbride; Angela M Farrelly; Caroline Bonner; Manus W Ward; Kristine C Nyhan; Caoimhín G Concannon; Claes B Wollheim; Maria M Byrne; Jochen H M Prehn
AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF.
The Journal of biological chemistry 2010;285(46):36199-206.
2010: Caroline Bonner; Siobhán Bacon; Caoimhín G Concannon; Syed R Rizvi; Mathurin Baquié; Angela M Farrelly; Seán M Kilbride; Heiko Dussmann; Manus W Ward; Chantal M Boulanger; Claes B Wollheim; Rolf Graf; Maria M Byrne; Jochen H M Prehn
INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells.
Diabetes 2010;59(11):2799-808.
2010: Dmitry Akhmedov; Matthias Braun; Chikage Mataki; Kyu-Sang Park; Tullio Pozzan; Kristina Schoonjans; Patrik Rorsman; Claes B Wollheim; Andreas Wiederkehr
Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(11):4613-26.
2010: Tina Wallin; Zuheng Ma; Hirotaka Ogata; Ingrid Hals Jørgensen; Mariella Iezzi; Haiyan Wang; Claes B Wollheim; Anneli Björklund
Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation.
Biochimica et biophysica acta 2010;1801(2):191-7.
2010: Olivier Lorenzi; Christelle Veyrat-Durebex; Claes B Wollheim; Pascal Villemin; Françoise Rohner-Jeanrenaud; Anne Zanchi; Ulrich M Vischer; Ulrich Vischer
Evidence against a direct role of klotho in insulin resistance.
Pflügers Archiv : European journal of physiology 2010;459(3):465-73.
2010: Clare L Kirkpatrick; Piero Marchetti; Francesco Purrello; Salvatore Piro; Marco Bugliani; Domenico Bosco; Eelco J P de Koning; Marten A Engelse; Julie Kerr Conte; François Pattou; Claes B Wollheim
Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors.
PloS one 2010;5(6):e11053.
2010: Yohann Couté; Yannick Brunner; Domitille Schvartz; Céline Hernandez; Alexandre Masselot; Frédérique Lisacek; Claes B Wollheim; jean-charles sanchez
Early activation of the fatty acid metabolism pathway by chronic high glucose exposure in rat insulin secretory beta-cells.
Proteomics 2010;10(1):59-71.
2009: Andreas Wiederkehr; Claes B Wollheim
Linking fatty acid stress to beta-cell mitochondrial dynamics.
Diabetes 2009;58(10):2185-6.
2009: Benoit R Gauthier; Andreas Wiederkehr; Mathurin Baquié; Chunhua Dai; Alvin C Powers; Julie Kerr Conte; François Pattou; Raymond J MacDonald; Jorge Ferrer; Claes B Wollheim
PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression.
Cell metabolism 2009;10(2):110-8.
2009: Rebecca L Pongratz; Richard G Kibbey; Clare L Kirkpatrick; Xiaojian Zhao; Marco Pontoglio; moshe yaniv; Claes B Wollheim; Gerald I Shulman; Gary W Cline
Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.
The Journal of biological chemistry 2009;284(25):16808-21.
2009: Xiuli Men; Haiyan Wang; Mi Li; Hanqing Cai; Shiqin Xu; Wenjian Zhang; Yaping Xu; Liya Ye; Wenying Yang; Claes B Wollheim; Jinning Lou
Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis.
The international journal of biochemistry & cell biology 2009;41(4):879-90.
2009: Andreas Wiederkehr; Kyu-Sang Park; Olivier Dupont; Nicolas Demaurex; Tullio Pozzan; Gary W Cline; Claes B Wollheim
Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation.
The EMBO journal 2009;28(4):417-28.
2009: Patricia Mármol; Beatriz Pardo; Andreas Wiederkehr; Araceli del Arco; Claes B Wollheim; Jorgina Satrústegui
Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells.
The Journal of biological chemistry 2009;284(1):515-24.
2008: Bo Qian; Haiyan Wang; Xiuli Men; Wenjian Zhang; Hanqing Cai; Shiqing Xu; Yaping Xu; Liya Ye; Claes B Wollheim; Jinning Lou
TRIB3 [corrected] is implicated in glucotoxicity- and endoplasmic reticulum-stress-induced [corrected] beta-cell apoptosis.
The Journal of endocrinology 2008;199(3):407-16.
2008: Benoit R Gauthier; Claes B Wollheim
Synaptotagmins bind calcium to release insulin.
American journal of physiology. Endocrinology and metabolism 2008;295(6):E1279-86.
2008: Kyu-Sang Park; Andreas Wiederkehr; Clare Kirkpatrick; Yves Mattenberger; Jean-Claude Martinou; Piero Marchetti; Nicolas Demaurex; Claes B Wollheim
Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells.
The Journal of biological chemistry 2008;283(48):33347-56.
2008: Anaïs Perilhou; Cécile Tourrel-Cuzin; Pili Zhang; Ilham Kharroubi; Haiyan Wang; Véronique Fauveau; Donald Scott; Claes B Wollheim; Mireille Vasseur-Cognet
The MODY1 gene for hepatocyte nuclear factor 4alpha and a feedback loop control COUP-TFII expression in pancreatic beta cells.
Molecular and cellular biology 2008;28(14):4588-97.
2008: Andreas Wiederkehr; Claes B Wollheim
Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell.
Cell calcium 2008;44(1):64-76.
2008: Fabienne Jaques; Hélène Jousset; Alejandra Tomas; Anne-Lise Prost; Claes B Wollheim; Jean-Claude Irminger; Nicolas Demaurex; Philippe A Halban
Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion.
Endocrinology 2008;149(5):2494-505.
2008: Benoit R Gauthier; Dominique L Duhamel; Mariella Iezzi; Sten Theander; Frédéric Saltel; Mitsunori Fukuda; Bernhard Wehrle-Haller; Claes B Wollheim
Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(1):194-206.
2007: David M Keller; Shannon McWeeney; Athanasios Arsenlis; Jacques Drouin; Christopher V E Wright; Haiyan Wang; Claes B Wollheim; Peter White; Klaus kaestner; Richard H Goodman
Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy.
The Journal of biological chemistry 2007;282(44):32084-92.
2007: Thierry Brun; D L Duhamel; K H Hu He; Claes B Wollheim; Benoit R Gauthier
The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells.
Oncogene 2007;26(29):4261-71.
2007: Yannick Brunner; Yohann Couté; Mariella Iezzi; Michelangelo Foti; Mitsonuri Fukuda; Denis F Hochstrasser; Claes B Wollheim; jean-charles sanchez
Proteomics analysis of insulin secretory granules.
Molecular & cellular proteomics : MCP 2007;6(6):1007-17.
2007: Richard G Kibbey; Rebecca L Pongratz; Anthony J Romanelli; Claes B Wollheim; Gary W Cline; Gerald I Shulman
Mitochondrial GTP regulates glucose-stimulated insulin secretion.
Cell metabolism 2007;5(4):253-64.
2007: Desiree M Schumann; Kathrin Maedler; Isobel Franklin; Daniel Konrad; Joachim Størling; Marianne Böni-Schnetzler; Asllan Gjinovci; Michael O Kurrer; Benoit R Gauthier; Domenico Bosco; Axel Andres; Thierry Berney; Melanie Greter; Burkhard Becher; Alexander V Chervonsky; Philippe A Halban; Thomas Mandrup-Poulsen; Claes B Wollheim; Marc Y Donath
The Fas pathway is involved in pancreatic beta cell secretory function.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(8):2861-6.
2007: Jesper Gromada; Isobel Franklin; Claes B Wollheim
Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains.
Endocrine reviews 2007;28(1):84-116.
2007: Haiyan Wang; Thierry Brun; K Kataoka; A J Sharma; Claes B Wollheim
MAFA controls genes implicated in insulin biosynthesis and secretion.
Diabetologia 2007;50(2):348-58.
2007: N Produit-Zengaffinen; Nathalie Davis-Lameloise; H Perreten; D Bécard; Asllan Gjinovci; Patrick A Keller; Claes B Wollheim; Pedro L Herrera; Patrick Muzzin; Françoise Assimacopoulos-Jeannet
Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species.
Diabetologia 2007;50(1):84-93.
2006: Kathrin Maedler; Desiree M Schumann; Nadine Sauter; Helga Ellingsgaard; Domenico Bosco; Reto M Baertschiger; Yoichiro Iwakura; José Oberholzer; Claes B Wollheim; Benoit R Gauthier; Marc Y Donath
Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets.
Diabetes 2006;55(10):2713-22.
2006: V Corcelle; B Stieger; Asllan Gjinovci; Claes B Wollheim; Benoit R Gauthier
Characterization of two distinct liver progenitor cell subpopulations of hematopoietic and hepatic origins.
Experimental cell research 2006;312(15):2826-36.
2006: Andreas Wiederkehr; Claes B Wollheim
Minireview: implication of mitochondria in insulin secretion and action.
Endocrinology 2006;147(6):2643-9.
2006: Benoit R Gauthier; Claes B Wollheim
[Glucose homeostasis ribo-regulated by microRNA].
Médecine sciences : M/S 2006;22(5):463-5.
2006: Benoit R Gauthier; Claes B Wollheim
MicroRNAs: 'ribo-regulators' of glucose homeostasis.
Nature medicine 2006;12(1):36-8.
2005: Kenji Fukui; Qin Yang; Yang Cao; Noriko Takahashi; Hiroyasu Hatakeyama; Haiyan Wang; Jun Wada; Yanling Zhang; Lorella Marselli; Takao Nammo; Kazue Yoneda; Mineki Onishi; Shigeki Higashiyama; Yuji Matsuzawa; Frank J Gonzalez; Gordon C Weir; Haruo Kasai; Iichiro Shimomura; Jun-ichiro Miyagawa; Claes B Wollheim; Kazuya Yamagata
The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation.
Cell metabolism 2005;2(6):373-84.
2005: Mariella Iezzi; Sten Theander; Roger Janz; Chantal Loze; Claes B Wollheim
SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment.
Journal of cell science 2005;118(Pt 23):5647-60.
2005: Hervør Lykke Olsen; Sten Theander; Krister Bokvist; Karsten Buschard; Claes B Wollheim; Jesper Gromada
Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells.
Endocrinology 2005;146(11):4861-70.
2005: Mariella Iezzi; Lena Eliasson; Mitsunori Fukuda; Claes B Wollheim
Adenovirus-mediated silencing of synaptotagmin 9 inhibits Ca2+-dependent insulin secretion in islets.
FEBS letters 2005;579(23):5241-6.
2005: Haiyan Wang; Georgia Kouri; Claes B Wollheim
ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity.
Journal of cell science 2005;118(Pt 17):3905-15.
2005: Haiyan Wang; Claes B Wollheim
Does chasing selected 'Fox' to the nucleus prevent diabetes?
Trends in molecular medicine 2005;11(6):262-5.
2005: Isobel Franklin; Jesper Gromada; Asllan Gjinovci; Sten Theander; Claes B Wollheim
Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release.
Diabetes 2005;54(6):1808-15.
2005: Magalie A Ravier; Martin Güldenagel; Anne Charollais; Asllan Gjinovci; Dorothée Caille; Goran Söhl; Claes B Wollheim; Klaus Willecke; Jean-Claude Henquin; Paolo Meda
Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release.
Diabetes 2005;54(6):1798-807.
2005: Anna Biason-Lauber; B Boehm; Mariarosaria Lang-Muritano; Benoit R Gauthier; Thierry Brun; Claes B Wollheim; Eugen J Schoenle
Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity.
Diabetologia 2005;48(5):900-5.
2005: Thierry Brun; Claes B Wollheim; Benoit R Gauthier
[Pax4, islet plasticity and diabetes].
Médecine sciences : M/S 2005;21(4):358-9.
2005: Haiyan Wang; Mariella Iezzi; Sten Theander; Peter A Antinozzi; Benoit R Gauthier; Philippe A Halban; Claes B Wollheim
Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells.
Diabetologia 2005;48(4):720-31.
2004: Thierry Brun; Isobel Franklin; Luc St-Onge; Anna Biason-Lauber; Eugen J Schoenle; Claes B Wollheim; Benoit R Gauthier
The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets.
The Journal of cell biology 2004;167(6):1123-35.
2004: Maria Sörhede Winzell; Giovanni Pacini; Claes B Wollheim; Bo Ahrén
Beta-cell-targeted expression of a dominant-negative mutant of hepatocyte nuclear factor-1alpha in mice: diabetes model with beta-cell dysfunction partially rescued by nonglucose secretagogues.
Diabetes 2004;53 Suppl 3():S92-6.
2004: Benoit R Gauthier; Thierry Brun; Eve Julie Sarret; Hisamitsu Ishihara; Olivier Schaad; Patrick Descombes; Claes B Wollheim
Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets.
The Journal of biological chemistry 2004;279(30):31121-30.
2004: Mariella Iezzi; Georgia Kouri; Mitsunori Fukuda; Claes B Wollheim
Synaptotagmin V and IX isoforms control Ca2+ -dependent insulin exocytosis.
Journal of cell science 2004;117(Pt 15):3119-27.
2004: Isobel K Franklin; Claes B Wollheim
GABA in the endocrine pancreas: its putative role as an islet cell paracrine-signalling molecule.
The Journal of general physiology 2004;123(3):185-90.
2004: Frédéric Preitner; Mark Ibberson; Isobel Franklin; Christophe BINNERT; Mario Pende; Asllan Gjinovci; Tanya Hansotia; Daniel J Drucker; Claes B Wollheim; Rémy Burcelin; Bernard Thorens
Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors.
The Journal of clinical investigation 2004;113(4):635-45.
2004: Arnaud Merglen; Sten Theander; Blanca Rubi; Gaelle Chaffard; Claes B Wollheim; Pierre Maechler
Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells.
Endocrinology 2004;145(2):667-78.
2003: Verena Schulla; Erik Renström; Robert Feil; Susanne Feil; Isobel Franklin; Asllan Gjinovci; Xing-Jun Jing; Dirk Laux; Ingmar Lundquist; Mark Magnuson; Stefanie Obermüller; Charlotta S Olofsson; Albert Salehi; Anna Wendt; Norbert Klugbauer; Claes B Wollheim; Patrik Rorsman; Franz Hofmann
Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice.
The EMBO journal 2003;22(15):3844-54.
2003: Haiyan Wang; Pierre Maechler; Peter A Antinozzi; Laura Herrero; Kerstin A Hagenfeldt-Johansson; Anneli Bjorklund; Claes B Wollheim
The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction.
The Journal of biological chemistry 2003;278(19):16622-9.
2003: Bumsup Lee; Philip D Miles; Leonardo Vargas; Peng Luan; Susan Glasco; Yulia Kushnareva; Elisabeth S Kornbrust; Kathryn A Grako; Claes B Wollheim; Pierre Maechler; Jerrold M Olefsky; Christen M Anderson
Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets.
Diabetes 2003;52(4):965-73.
2003: Hisamitsu Ishihara; Pierre Maechler; Asllan Gjinovci; Pedro L Herrera; Claes B Wollheim
Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells.
Nature cell biology 2003;5(4):330-5.
2002: Haiyan Wang; Kerstin A Hagenfeldt-Johansson; Luc A Otten; Benoit R Gauthier; Pedro L Herrera; Claes B Wollheim
Experimental models of transcription factor-associated maturity-onset diabetes of the young.
Diabetes 2002;51 Suppl 3():S333-42.
2002: Marianne Høy; Pierre Maechler; Alexander M Efanov; Claes B Wollheim; Per-Olof Berggren; Jesper Gromada
Increase in cellular glutamate levels stimulates exocytosis in pancreatic beta-cells.
FEBS letters 2002;531(2):199-203.
2002: Haiyan Wang; Claes B Wollheim
ChREBP rather than USF2 regulates glucose stimulation of endogenous L-pyruvate kinase expression in insulin-secreting cells.
The Journal of biological chemistry 2002;277(36):32746-52.
2002: Reut Bartoov-Shifman; Rachel Hertz; Haiyan Wang; Claes B Wollheim; Jacob Bar-Tana; Michael D Walker
Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alpha.
The Journal of biological chemistry 2002;277(29):25914-9.
2002: Qin Yang; Kazuya Yamagata; Kenji Fukui; Yang Cao; Takao Nammo; Hiromi Iwahashi; Haiyan Wang; Itaru Matsumura; Toshiaki Hanafusa; Richard Bucala; Claes B Wollheim; Jun-ichiro Miyagawa; Yuji Matsuzawa
Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells.
Diabetes 2002;51(6):1785-92.
2002: Haiyan Wang; Benoit R Gauthier; Kerstin A Hagenfeldt-Johansson; Mariella Iezzi; Claes B Wollheim
Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release.
The Journal of biological chemistry 2002;277(20):17564-70.
2002: Blanca Rubí; Peter A Antinozzi; Laura Herrero; Hisamitsu Ishihara; Guillermina Asins; Dolors Serra; Claes B Wollheim; Pierre Maechler; Fausto G Hegardt
Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion.
The Biochemical journal 2002;364(Pt 1):219-26.
2002: Peter A Antinozzi; Hisamitsu Ishihara; Christopher B Newgard; Claes B Wollheim
Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues.
The Journal of biological chemistry 2002;277(14):11746-55.
2002: Hella Wobser; Heiko Düssmann; Donat Kögel; Haiyan Wang; Claus Reimertz; Claes B Wollheim; Maria M Byrne; Jochen H M Prehn
Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death.
The Journal of biological chemistry 2002;277(8):6413-21.
2002: Pierre Maechler; Asllan Gjinovci; Claes B Wollheim
Implication of glutamate in the kinetics of insulin secretion in rat and mouse perfused pancreas.
Diabetes 2002;51 Suppl 1():S99-102.
2002: Claes B Wollheim; Pierre Maechler
Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites.
Diabetes 2002;51 Suppl 1():S37-42.
2001: Kerstin A Hagenfeldt-Johansson; Pedro L Herrera; Haiyan Wang; Asllan Gjinovci; H Ishihara; Claes B Wollheim
Beta-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1 alpha induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice.
Endocrinology 2001;142(12):5311-20.
2001: Blanca Rubi; H Ishihara; Fausto G Hegardt; Claes B Wollheim; Pierre Maechler
GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells.
The Journal of biological chemistry 2001;276(39):36391-6.
2001: Haiyan Wang; Pierre Maechler; Beate Ritz-Laser; KA Hagenfeldt; H Ishihara; Jacques Philippe; Claes B Wollheim
Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation.
The Journal of biological chemistry 2001;276(27):25279-86.
2001: Domenico Bosco; Carmen Gonelle-Gispert; Claes B Wollheim; Philippe A Halban; Dominique G Rouiller
Increased intracellular calcium is required for spreading of rat islet beta-cells on extracellular matrix.
Diabetes 2001;50(5):1039-46.
2001: Anne M Gut; C E Kiraly; M Fukuda; K Mikoshiba; Claes B Wollheim; Jochen Lang
Expression and localisation of synaptotagmin isoforms in endocrine beta-cells: their function in insulin exocytosis.
Journal of cell science 2001;114(Pt 9):1709-16.
2000: Haiyan Wang; Pierre Maechler; Peter A Antinozzi; KA Hagenfeldt; Claes B Wollheim
Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion.
The Journal of biological chemistry 2000;275(46):35953-9.
2000: Haiyan Wang; Peter A Antinozzi; KA Hagenfeldt; Pierre Maechler; Claes B Wollheim
Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction.
The EMBO journal 2000;19(16):4257-64.
2000: Pierre Maechler; Peter A Antinozzi; Claes B Wollheim
Modulation of glutamate generation in mitochondria affects hormone secretion in INS-1E beta cells.
IUBMB life 2000;50(1):27-31.
2000: Anne Charollais; Asllan Gjinovci; Joachim Huarte; Juliette Bauquis; Angel Nadal; F Martín; Etelvina Andreu; JV Sánchez-Andrés; Alessandra Calabrese; Domenico Bosco; Bernat Soria; Claes B Wollheim; Pedro L Herrera; Paolo Meda
Junctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose tolerance.
The Journal of clinical investigation 2000;106(2):235-43.
2000: Mariella Iezzi; Romano Regazzi; Claes B Wollheim
The Rab3-interacting molecule RIM is expressed in pancreatic beta-cells and is implicated in insulin exocytosis.
FEBS letters 2000;474(1):66-70.
2000: H Ishihara; Claes B Wollheim
What couples glycolysis to mitochondrial signal generation in glucose-stimulated insulin secretion?
IUBMB life 2000;49(5):391-5.
2000: Claes B Wollheim
Beta-cell mitochondria in the regulation of insulin secretion: a new culprit in type II diabetes.
Diabetologia 2000;43(3):265-77.
1999: Kohei Okita; Qin Yang; Kazuya Yamagata; K A Hangenfeldt; Jun-ichiro Miyagawa; Yoshitaka Kajimoto; Hiromu Nakajima; Mitsuyoshi Namba; Claes B Wollheim; Toshiaki Hanafusa; Yuji Matsuzawa
Human insulin gene is a target gene of hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta.
Biochemical and biophysical research communications 1999;263(2):566-9.
1999: Pierre Maechler; Lan Jornot; Claes B Wollheim
Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells.
The Journal of biological chemistry 1999;274(39):27905-13.
1999: Jinning Lou; Frédéric Triponez; José Oberholzer; H Wang; D Yu; Leo H Buhler; Nathalie Cretin; Gilles Mentha; Claes B Wollheim; Philippe Morel
Expression of alpha-1 proteinase inhibitor in human islet microvascular endothelial cells.
Diabetes 1999;48(9):1773-8.
1999: Pierre Maechler; ED Kennedy; E Sebö; A Valeva; T Pozzan; Claes B Wollheim
Secretagogues modulate the calcium concentration in the endoplasmic reticulum of insulin-secreting cells. Studies in aequorin-expressing intact and permeabilized ins-1 cells.
The Journal of biological chemistry 1999;274(18):12583-92.
1999: Lan Jornot; Pierre Maechler; Claes B Wollheim; AF Junod
Reactive oxygen metabolites increase mitochondrial calcium in endothelial cells: implication of the Ca2+/Na+ exchanger.
Journal of cell science 1999;112 ( Pt 7)():1013-22.
1999: Mariella Iezzi; G Escher; Paolo Meda; Anne Charollais; G Baldini; F Darchen; Claes B Wollheim; Romano Regazzi
Subcellular distribution and function of Rab3A, B, C, and D isoforms in insulin-secreting cells.
Molecular endocrinology (Baltimore, Md.) 1999;13(2):202-12.
1998: Haiyan Wang; Pierre Maechler; KA Hagenfeldt; Claes B Wollheim
Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.
The EMBO journal 1998;17(22):6701-13.
1998: H Zhang; W L Kelley; L H Chamberlain; R D Burgoyne; Claes B Wollheim; Jochen Lang
Cysteine-string proteins regulate exocytosis of insulin independent from transmembrane ion fluxes.
FEBS letters 1998;437(3):267-72.
1998: Pierre Maechler; ED Kennedy; Haiyan Wang; Claes B Wollheim
Desensitization of mitochondrial Ca2+ and insulin secretion responses in the beta cell.
The Journal of biological chemistry 1998;273(33):20770-8.
1998: W J Scheenen; Claes B Wollheim; Tullio Pozzan; Cristina Fasolato
Ca2+ depletion from granules inhibits exocytosis. A study with insulin-secreting cells.
The Journal of biological chemistry 1998;273(30):19002-8.
1998: ED Kennedy; Pierre Maechler; Claes B Wollheim
Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells.
Diabetes 1998;47(3):374-80.
1998: Pierre Maechler; H Wang; Claes B Wollheim
Continuous monitoring of ATP levels in living insulin secreting cells expressing cytosolic firefly luciferase.
FEBS letters 1998;422(3):328-32.
1998: Jochen Lang; Y Ushkaryov; A Grasso; Claes B Wollheim
Ca2+-independent insulin exocytosis induced by alpha-latrotoxin requires latrophilin, a G protein-coupled receptor.
The EMBO journal 1998;17(3):648-57.
1998: ED Kennedy; Claes B Wollheim
Role of mitochondrial calcium in metabolism-secretion coupling in nutrient-stimulated insulin release.
Diabetes & metabolism 1998;24(1):15-24.
1997: J Land; H Zhang; V V Vaidyanathan; Karin Sadoul; H Niemann; Claes B Wollheim
Transient expression of botulinum neurotoxin C1 light chain differentially inhibits calcium and glucose induced insulin secretion in clonal beta-cells.
FEBS letters 1997;419(1):13-7.
1997: M Arribas; R Regazzi; E Garcia; Claes B Wollheim; Pietro De Camilli
The stimulatory effect of rabphilin 3a on regulated exocytosis from insulin-secreting cells does not require an association-dissociation cycle with membranes mediated by Rab 3.
European journal of cell biology 1997;74(3):209-16.
1997: Nobuo Sekine; Cristina Fasolato; W F Pralong; J M Theler; Claes B Wollheim
Glucose-induced insulin secretion in INS-1 cells depends on factors present in fetal calf serum and rat islet-conditioned medium.
Diabetes 1997;46(9):1424-33.
1997: Pierre Maechler; ED Kennedy; T Pozzan; Claes B Wollheim
Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells.
The EMBO journal 1997;16(13):3833-41.