FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Axel Wollmer

Research Profile

Phenomena

Circular Dichroism

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Chemicals & Drugs

Procedures

Fluorescence Spectrometry

Physiology

Protein Folding

Co-author Network

Publications

TOP 3
Wolfgang Swegat; Jürgen Schlitter; Peter Krüger; Axel Wollmer
MD simulation of protein-ligand interaction: formation and dissociation of an insulin-phenol complex.
S Pflanz; Thomas Kernebeck; Bernd Giese; Andreas Herrmann; M Pachta-Nick; J Stahl; Axel Wollmer; Peter C Heinrich; Gerhard Müller-Newen; Joachim Grötzinger
Signal transducer gp130: biochemical characterization of the three membrane-proximal extracellular domains and evaluation of their oligomerization potential.
Gert De Wilde; Judith Murray-Rust; Elke Boone; D Olerenshaw; Neil McDonald; C Ibanez; Guy Haegeman; Axel Wollmer; M Federwisch
Structure-activity relationship of the p55 TNF receptor death domain and its lymphoproliferation mutants.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Axel Wollmer (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2003: Wolfgang Swegat; Jürgen Schlitter; Peter Krüger; Axel Wollmer
MD simulation of protein-ligand interaction: formation and dissociation of an insulin-phenol complex.
Biophysical journal 2003;84(3):1493-506.
2001: S Pflanz; Thomas Kernebeck; Bernd Giese; Andreas Herrmann; M Pachta-Nick; J Stahl; Axel Wollmer; Peter C Heinrich; Gerhard Müller-Newen; Joachim Grötzinger
Signal transducer gp130: biochemical characterization of the three membrane-proximal extracellular domains and evaluation of their oligomerization potential.
The Biochemical journal 2001;356(Pt 2):605-12.
2001: Gert De Wilde; Judith Murray-Rust; Elke Boone; D Olerenshaw; Neil McDonald; C Ibanez; Guy Haegeman; Axel Wollmer; M Federwisch
Structure-activity relationship of the p55 TNF receptor death domain and its lymphoproliferation mutants.
European journal of biochemistry / FEBS 2001;268(5):1382-91.
2000: J Shneine; M Voswinkel; M Federwisch; Axel Wollmer
Enhancing the T-->R transition of insulin by helix-promoting sequence modifications at the N-terminal B-chain.
Biological chemistry 2000;381(2):127-33.
1999: U Hassiepen; M Federwisch; T Mülders; Axel Wollmer
The lifetime of insulin hexamers.
Biophysical journal 1999;77(3):1638-54.
1999: G Kurapkat; M Siedentop; HG Gattner; M Hagelstein; D Brandenburg; Joachim Grötzinger; Axel Wollmer
The solution structure of a superpotent B-chain-shortened single-replacement insulin analogue.
Protein science : a publication of the Protein Society 1999;8(3):499-508.
1999: Serge Haan; U Hemmann; U Hassiepen; Fred Schaper; Jens Schneider-Mergener; Axel Wollmer; Peter C Heinrich; Joachim Grötzinger
Characterization and binding specificity of the monomeric STAT3-SH2 domain.
The Journal of biological chemistry 1999;274(3):1342-8.
1999: Thomas Kernebeck; S Pflanz; Gerhard Müller-Newen; G Kurapkat; Ruud M Scheek; Klaas Dijkstra; Peter C Heinrich; Axel Wollmer; S Grzesiek; Joachim Grötzinger
The signal transducer gp130: solution structure of the carboxy-terminal domain of the cytokine receptor homology region.
Protein science : a publication of the Protein Society 1999;8(1):5-12.
1998: Suat Ozbek; Joachim Grötzinger; B Krebs; Martina Fischer; Axel Wollmer; Thomas Jostock; Jürgen Müllberg; Stefan Rose-John
The membrane proximal cytokine receptor domain of the human interleukin-6 receptor is sufficient for ligand binding but not for gp130 association.
The Journal of biological chemistry 1998;273(33):21374-9.
1998: U Hassiepen; M Federwisch; T Mülders; V J Lenz; HG Gattner; Peter Krüger; Axel Wollmer
Analysis of protein self-association at constant concentration by fluorescence-energy transfer.
European journal of biochemistry / FEBS 1998;255(3):580-7.
1998: Peter C Heinrich; Friedemann Horn; Lutz Graeve; E Dittrich; Ian M Kerr; Gerhard Müller-Newen; Joachim Grötzinger; Axel Wollmer
Interleukin-6 and related cytokines: effect on the acute phase reaction.
Zeitschrift für Ernährungswissenschaft 1998;37 Suppl 1():43-9.
1997: Heinz-Jürgen Steinhoff; Nicole Radzwill; W Thevis; V Lenz; D Brandenburg; Alfred A Antson; G Dodson; Axel Wollmer
Determination of interspin distances between spin labels attached to insulin: comparison of electron paramagnetic resonance data with the X-ray structure.
Biophysical journal 1997;73(6):3287-98.
1997: Michael Kalai; Félix A Montero-Julian; J P Brakenhoff; V Fontaine; L De Wit; Axel Wollmer; H Brailly; Jean Content; Joachim Grötzinger
Analysis of the mechanism of action of anti-human interleukin-6 and anti-human interleukin-6 receptor-neutralising monoclonal antibodies.
European journal of biochemistry / FEBS 1997;249(3):690-700.
1997: U Fagin; Ulrich Hahn; J Grötzinger; B Fleischer; D Gerlach; F Buck; Axel Wollmer; Holger Kirchner; Lothar Rink
Exclusion of bioactive contaminations in Streptococcus pyogenes erythrogenic toxin A preparations by recombinant expression in Escherichia coli.
Infection and immunity 1997;65(11):4725-33.
1997: U Horsten; Gerhard Müller-Newen; Claudia Gerhartz; Axel Wollmer; John Wijdenes; Peter C Heinrich; Joachim Grötzinger
Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex.
The Journal of biological chemistry 1997;272(38):23748-57.
1997: Gerhard Müller-Newen; S Pflanz; U Hassiepen; J Stahl; Axel Wollmer; Peter C Heinrich; Joachim Grötzinger
The signal transducer gp130--bacterial expression, refolding and properties of the carboxy-terminal domain of the cytokine-binding module.
European journal of biochemistry / FEBS 1997;247(1):425-31.
1997: M Federwisch; U Hassiepen; K Bender; M Dewor; Manfred F Rajewsky; Axel Wollmer
Recombinant human O6-alkylguanine-DNA alkyltransferase (AGT), Cys145-alkylated AGT and Cys145 --> Met145 mutant AGT: comparison by isoelectric focusing, CD and time-resolved fluorescence spectroscopy.
The Biochemical journal 1997;324 ( Pt 1)():321-8.
1997: M Federwisch; U Hassiepen; K Bender; Manfred F Rajewsky; Axel Wollmer
Recombinant human O6-alkylguanine-DNA alkyltransferase induces conformational change in bound DNA.
FEBS letters 1997;407(3):333-6.
1997: G Kurapkat; E De Wolf; Joachim Grötzinger; Axel Wollmer
Inactive conformation of an insulin despite its wild-type sequence.
Protein science : a publication of the Protein Society 1997;6(3):580-7.
1997: G Kurapkat; Peter Krüger; Axel Wollmer; Jörg Fleischhauer; B Kramer; E Zobel; Axel Koslowski; H Botterweck; Robert W Woody
Calculations of the CD spectrum of bovine pancreatic ribonuclease.
Biopolymers 1997;41(3):267-87.
1997: Michael Kalai; Félix A Montero-Julian; Joachim Grötzinger; V Fontaine; Paul Vandenbussche; R Deschuyteneer; Axel Wollmer; H Brailly; Jean Content
Analysis of the human interleukin-6/human interleukin-6 receptor binding interface at the amino acid level: proposed mechanism of interaction.
Blood 1997;89(4):1319-33.
1997: Martina Fischer; J Goldschmitt; Christian Peschel; J P Brakenhoff; Karl-Josef Kallen; Axel Wollmer; Joachim Grötzinger; Stefan Rose-John
I. A bioactive designer cytokine for human hematopoietic progenitor cell expansion.
Nature biotechnology 1997;15(2):142-5.
1997: Joachim Grötzinger; G Kurapkat; Axel Wollmer; Michael Kalai; Stefan Rose-John
The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes.
Proteins 1997;27(1):96-109.
1996: R Gill; B Wallach; C Verma; Birgitte Uraø; E De Wolf; Joachim Grötzinger; Judith Murray-Rust; J Pitts; Axel Wollmer; Pierre De Meyts; S Wood
Engineering the C-region of human insulin-like growth factor-1: implications for receptor binding.
Protein engineering 1996;9(11):1011-9.
1996: E De Wolf; R Gill; S Geddes; J Pitts; Axel Wollmer; Joachim Grötzinger
Solution structure of a mini IGF-1.
Protein science : a publication of the Protein Society 1996;5(11):2193-202.
1996: Michael Kalai; Félix A Montero-Julian; Joachim Grötzinger; Axel Wollmer; D Morelle; J Brochier; Stefan Rose-John; Peter C Heinrich; H Brailly; Jean Content
Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor.
European journal of biochemistry / FEBS 1996;238(3):714-23.
1996: U Hemmann; C Gerhartz; B Heesel; J Sasse; G Kurapkat; Joachim Grötzinger; Axel Wollmer; Z Zhong; J E Darnell; Lutz Graeve; Peter C Heinrich; Friedemann Horn
Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation.
The Journal of biological chemistry 1996;271(22):12999-3007.
1996: E Jacoby; Peter Krüger; J Schlitter; D Röper; Axel Wollmer
Simulation of a complex protein structural change: the T <--> R transition in the insulin hexamer.
Protein engineering 1996;9(2):113-25.
1996: O Weiergräber; Jens Schneider-Mergener; Joachim Grötzinger; Axel Wollmer; Andrea Küster; M Exner; Peter C Heinrich
Use of immobilized synthetic peptides for the identification of contact sites between human interleukin-6 and its receptor.
FEBS letters 1996;379(2):122-6.
1996: U Raffetseder; D Röper; L Mery; C Gietz; Andreas Klos; Joachim Grötzinger; Axel Wollmer; François Boulay; Jörg Köhl; Wilfried Bautsch
Site-directed mutagenesis of conserved charged residues in the helical region of the human C5a receptor. Arg2O6 determines high-affinity binding sites of C5a receptor.
European journal of biochemistry / FEBS 1996;235(1-2):82-90.
1995: S Leyer; HG Gattner; M Leithäuser; D Brandenburg; Axel Wollmer; Hartwig Höcker
The role of the C-terminus of the insulin B-chain in modulating structural and functional properties of the hormone.
International journal of peptide and protein research 1995;46(5):397-407.
1995: Marc Ehlers; Joachim Grötzinger; F D de Hon; Jürgen Müllberg; J P Brakenhoff; Axel Wollmer; Stefan Rose-John
Residues 77-95 of the human interleuken-6 protein are responsible for receptor binding and residues 41-56 for signal transduction.
Annals of the New York Academy of Sciences 1995;762():400-2.
1995: A Krüttgen; Joachim Grötzinger; G Kurapkat; Joachim Weis; R Simon; M Thier; M Schröder; P Heinrich; Axel Wollmer; M Comeau
Human ciliary neurotrophic factor: a structure-function analysis.
The Biochemical journal 1995;309 ( Pt 1)():215-20.
1995: V J Lenz; M Federwisch; HG Gattner; D Brandenburg; Hartwig Höcker; U Hassiepen; Axel Wollmer
Structure and rotational dynamics of fluorescently labeled insulin in aqueous solution and at the amphiphile-water interface of reversed micelles.
Biochemistry 1995;34(18):6130-41.
1995: Marc Ehlers; F D de Hon; H K Bos; U Horsten; G Kurapkat; H S van De Leur; Joachim Grötzinger; Axel Wollmer; J P Brakenhoff; Stefan Rose-John
Combining two mutations of human interleukin-6 that affect gp130 activation results in a potent interleukin-6 receptor antagonist on human myeloma cells.
The Journal of biological chemistry 1995;270(14):8158-63.
1995: D Röper; Peter Krüger; Joachim Grötzinger; Axel Wollmer; W Strassburger
Models of G-protein coupled receptors revised for family-wide compliance with experimental data. A new sequence accommodation suggested for helix G.
Receptors & channels 1995;3(2):97-106.
1994: V J Lenz; HG Gattner; M Leithäuser; D Brandenburg; Axel Wollmer; Hartwig Höcker
Proteolyses of a fluorogenic insulin derivative and native insulin in reversed micelles monitored by fluorescence emission, reversed-phase high-performance liquid chromatography, and capillary zone electrophoresis.
Analytical biochemistry 1994;221(1):85-93.
1994: Marc Ehlers; Joachim Grötzinger; F D deHon; Jürgen Müllberg; J P Brakenhoff; J Liu; Axel Wollmer; Stefan Rose-John
Identification of two novel regions of human IL-6 responsible for receptor binding and signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(4):1744-53.
1994: D Röper; E Jacoby; Peter Krüger; M Engels; Joachim Grötzinger; Axel Wollmer; W Strassburger
Modeling of G-protein coupled receptors with bacteriorhodopsin as a template. A novel approach based on interaction energy differences.
Journal of receptor research 1994;14(3-4):167-86.
1994: Jörg Fleischhauer; Joachim Grötzinger; B Kramer; Peter Krüger; Axel Wollmer; Robert W Woody; E Zobel
Calculation of the circular dichroism spectrum of cyclo-(L-tyr-L-tyr) based on a molecular dynamics simulation.
Biophysical chemistry 1994;49(2):141-52.
1994: Axel Wollmer; G Gilge; D Brandenburg; HG Gattner
An insulin with the native sequence but virtually no activity.
Biological chemistry Hoppe-Seyler 1994;375(3):219-22.
1994: P Bubeck; Joachim Grötzinger; M Winkler; Jörg Köhl; Axel Wollmer; Andreas Klos; Wilfried Bautsch
Site-specific mutagenesis of residues in the human C5a anaphylatoxin which are involved in possible interaction with the C5a receptor.
European journal of biochemistry / FEBS 1994;219(3):897-904.
1994: Peter Krüger; J Hahnen; Axel Wollmer
Comparative studies on the dynamics of crosslinked insulin.
European biophysics journal : EBJ 1994;23(3):177-87.
1993: E Jacoby; Peter Krüger; Y Karatas; Axel Wollmer
Distinction of structural reorganisation and ligand binding in the T<==>R transition of insulin on the basis of allosteric models.
Biological chemistry Hoppe-Seyler 1993;374(9):877-85.
1993: M Federwisch; Axel Wollmer; M Emde; T Stühmer; T Melcher; Andreas Klos; Jörg Köhl; Wilfried Bautsch
Tryptophan mutants of human C5a anaphylatoxin: a fluorescence anisotropy decay and energy transfer study.
Biophysical chemistry 1993;46(3):237-48.
1993: M Pohl; D Ambrosius; Joachim Grötzinger; T Kretzschmar; D Saunders; Axel Wollmer; D Brandenburg; D Bitter-Suermann; Hartwig Höcker
Cyclic disulfide analogues of the complement component C3a. Synthesis and conformational investigations.
International journal of peptide and protein research 1993;41(4):362-75.
1992: George Panayotou; B Bax; Ivan T Gout; M Federwisch; B Wroblowski; R Dhand; M J Fry; T L Blundell; Axel Wollmer; Michael D Waterfield
Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes.
The EMBO journal 1992;11(12):4261-72.
1992: K R Hejnaes; S Bayne; L Nørskov; H H Sørensen; J Thomsen; Lauge Schäffer; Axel Wollmer; L Skriver
Development of an optimized refolding process for recombinant Ala-Glu-IGF-1.
Protein engineering 1992;5(8):797-806.
1992: Erik M Schaefer; H P Erickson; M Federwisch; Axel Wollmer; L Ellis
Structural organization of the human insulin receptor ectodomain.
The Journal of biological chemistry 1992;267(32):23393-402.
1992: M Engels; E Jacoby; Peter Krüger; J Schlitter; Axel Wollmer
The T<-->R structural transition of insulin; pathways suggested by targeted energy minimization.
Protein engineering 1992;5(7):669-77.
1992: M Federwisch; M Casaretto; Rita Gerardy-Schahn; D Bitter-Suermann; Axel Wollmer
Enhanced biopotency of synthetic C3a analogues by membrane binding. A fluorescence anisotropy decay study.
Biophysical chemistry 1992;44(3):151-61.
1991: Y Karataş; Peter Krüger; Axel Wollmer
Kinetic measurements of T----R structural transitions in insulin.
Biological chemistry Hoppe-Seyler 1991;372(12):1035-8.
1991: Joachim Grötzinger; M Engels; E Jacoby; Axel Wollmer; W Strassburger
A model for the C5a receptor and for its interaction with the ligand [corrected].
Protein engineering 1991;4(7):767-71.
1991: V Lenz; HG Gattner; D Sievert; Axel Wollmer; M Engels; Hartwig Höcker
Semisynthetic des-(B27-B30)-insulins with modified B26-tyrosine.
Biological chemistry Hoppe-Seyler 1991;372(7):495-504.
1991: H Flodgaard; E Ostergaard; S Bayne; A Svendsen; J Thomsen; M Engels; Axel Wollmer
Covalent structure of two novel neutrophile leucocyte-derived proteins of porcine and human origin. Neutrophile elastase homologues with strong monocyte and fibroblast chemotactic activities.
European journal of biochemistry / FEBS 1991;197(2):535-47.
1990: Peter Krüger; G Gilge; Y Cabuk; Axel Wollmer
Cooperativity and intermediate states in the T----R-structural transformation of insulin.
Biological chemistry Hoppe-Seyler 1990;371(8):669-73.
1990: H D Schulzki; B Kramer; Jörg Fleischhauer; D A Mercola; Axel Wollmer
Calcium-dependent distance changes in binary and ternary complexes of troponin.
European journal of biochemistry / FEBS 1990;189(3):683-92.
1990: A Krüttgen; Stefan Rose-John; C Möller; B Wroblowski; Axel Wollmer; Jürgen Müllberg; T Hirano; T Kishimoto; Peter C Heinrich
Structure-function analysis of human interleukin-6. Evidence for the involvement of the carboxy-terminus in function.
FEBS letters 1990;262(2):323-6.
1990: K R Hejnaes; B Sehested; H Worsaae; J Mølvig; Axel Wollmer
The effect of N-terminal extension on the structure and function of human interleukin-1 beta.
Biological chemistry Hoppe-Seyler 1990;371(1):23-30.
1990: Michael D Waterfield; C Greenfield; I Hiles; M Federwisch; Axel Wollmer; T L Blundell; N McDonald
The use of optical techniques to detect conformational changes associated with the interaction of epidermal growth factor and its receptor.
Advances in second messenger and phosphoprotein research 1990;24():301-6.
1989: C Greenfield; I Hiles; Michael D Waterfield; M Federwisch; Axel Wollmer; T L Blundell; N McDonald
Epidermal growth factor binding induces a conformational change in the external domain of its receptor.
The EMBO journal 1989;8(13):4115-23.
1989: B Thomas; Axel Wollmer
Cobalt probing of structural alternatives for insulin in solution.
Biological chemistry Hoppe-Seyler 1989;370(12):1235-44.
1989: Axel Wollmer; B Rannefeld; J Stahl; S G Melberg
Structural transition in the metal-free hexamer of protein-engineered [B13 Gln]insulin.
Biological chemistry Hoppe-Seyler 1989;370(9):1045-53.
1988: S Stoev; S Zakhariev; Evgeny Golovinsky; HG Gattner; V K Naithani; Axel Wollmer; D Brandenburg
Synthesis and properties of [A19-(p-fluorophenylalanine)] insulin.
Biological chemistry Hoppe-Seyler 1988;369(12):1307-15.
1988: Rita Gerardy-Schahn; D Ambrosius; M Casaretto; Joachim Grötzinger; D Saunders; Axel Wollmer; D Brandenburg; D Bitter-Suermann
Design and biological activity of a new generation of synthetic C3a analogues by combination of peptidic and non-peptidic elements.
The Biochemical journal 1988;255(1):209-16.
1988: I Eberspach; W Strassburger; U Glatter; C Gerday; Axel Wollmer
Interaction of parvalbumin of pike II with calcium and terbium ions.
Biochimica et biophysica acta 1988;952(1):67-76.
1987: Axel Wollmer; B Rannefeld; B R Johansen; K R Hejnaes; P Balschmidt; F B Hansen
Phenol-promoted structural transformation of insulin in solution.
Biological chemistry Hoppe-Seyler 1987;368(8):903-11.
1987: M Casaretto; M Spoden; C Diaconescu; HG Gattner; H Zahn; D Brandenburg; Axel Wollmer
Shortened insulin with enhanced in vitro potency.
Biological chemistry Hoppe-Seyler 1987;368(6):709-16.
1987: Peter Krüger; W Strassburger; Axel Wollmer; W F van Gunsteren; G G Dodson
The simulated dynamics of the insulin monomer and their relationship to the molecule's structure.
European biophysics journal : EBJ 1987;14(8):449-59.
1986: M Bajaj; T L Blundell; richard horuk; JE Pitts; Steve P Wood; L K Gowan; Christian Schwabe; Axel Wollmer; J Gliemann; S Gammeltoft
Coypu insulin. Primary structure, conformation and biological properties of a hystricomorph rodent insulin.
The Biochemical journal 1986;238(2):345-51.
1986: W H Fischer; D Saunders; D Brandenburg; C Diaconescu; Axel Wollmer; G Dodson; Pierre De Meyts; H Zahn
Structure-function relationships of shortened [LeuB25]insulins, semisynthetic analogues of a mutant human insulin.
Biological chemistry Hoppe-Seyler 1986;367(9):999-1006.
1985: W H Fischer; D Saunders; D Brandenburg; Axel Wollmer; H Zahn
A shortened insulin with full in vitro potency.
Biological chemistry Hoppe-Seyler 1985;366(5):521-5.
1985: Peter Krüger; W Strassburger; Axel Wollmer; W F van Gunsteren
A comparison of the structure and dynamics of avian pancreatic polypeptide hormone in solution and in the crystal.
European biophysics journal : EBJ 1985;13(2):77-88.
1984: I D Glover; D J Barlow; JE Pitts; Steve P Wood; Ian Tickle; T L Blundell; K Tatemoto; J R Kimmel; Axel Wollmer; W Strassburger
Conformational studies on the pancreatic polypeptide hormone family.
European journal of biochemistry / FEBS 1984;142(2):379-85.
1984: H Renscheidt; W Strassburger; U Glatter; Axel Wollmer; G G Dodson; D A Mercola
A solution equivalent of the 2Zn----4Zn transformation of insulin in the crystal.
European journal of biochemistry / FEBS 1984;142(1):7-14.
1983: W Strassburger; Axel Wollmer; JE Pitts; I D Glover; Ian Tickle; T L Blundell; G J Steffens; W A Günzler; F Otting; Leopold Flohé
Adaptation of plasminogen activator sequences to known protease structures.
FEBS letters 1983;157(2):219-23.
1982: W Strassburger; U Glatter; Axel Wollmer; Jörg Fleischhauer; D A Mercola; T L Blundell; I Glover; JE Pitts; Ian Tickle; Steve P Wood
Calculated tyrosyl circular dichroism of proteins: absence of tryptophan and cystine interferences in avian pancreatic polypeptide.
FEBS letters 1982;139(2):295-9.
1980: R Jaenicke; B Gutte; U Glatter; W Strassburger; Axel Wollmer
Conformation of a synthetic 34-residue polypeptide that interacts with nucleic acids.
FEBS letters 1980;114(1):161-4.