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Fredric Wondisford

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Thyroid Hormone Resistance Syndrome

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Christopher Romero; Daniela I Sima; Fredric E Wondisford; Ling He; RYAN MILLER; Elyse Pine-Twaddell; Sally Radovick
Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactions.
Ricardo H Costa-E-Sousa; Fredric E Wondisford; Felix Ye; Inna Astapova; Anthony N Hollenberg
The thyroid axis is regulated by NCoR1 via its actions in the pituitary.
Ling He; Anlin Ma; Shumei Meng; Karuna Naik; Sally Radovick; Aniket Sidhaye; Jia Cao; Fredric E Wondisford
Transcriptional co-activator p300 maintains basal hepatic gluconeogenesis.

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2012: Christopher Romero; Daniela I Sima; Fredric E Wondisford; Ling He; RYAN MILLER; Elyse Pine-Twaddell; Sally Radovick
Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactions.
Molecular and cellular biology 2012;32(21):4258-69.
2012: Ricardo H Costa-E-Sousa; Fredric E Wondisford; Felix Ye; Inna Astapova; Anthony N Hollenberg
The thyroid axis is regulated by NCoR1 via its actions in the pituitary.
Endocrinology 2012;153(10):5049-57.
2012: Ling He; Anlin Ma; Shumei Meng; Karuna Naik; Sally Radovick; Aniket Sidhaye; Jia Cao; Fredric E Wondisford
Transcriptional co-activator p300 maintains basal hepatic gluconeogenesis.
The Journal of biological chemistry 2012;287(38):32069-77.
2012: RYAN MILLER; Sally Radovick; Andrew Wolfe; Ling He; Fredric E Wondisford
CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice.
Molecular and cellular biology 2012;32(13):2349-58.
2012: Maria Izabel Chiamolera; Koshi Hashimoto; Qiyi He; Shunichi Matsumoto; Tania M Ortiga-Carvalho; Aniket Sidhaye; Fredric E Wondisford
Fundamentally distinct roles of thyroid hormone receptor isoforms in a thyrotroph cell line are due to differential DNA binding.
Molecular endocrinology (Baltimore, Md.) 2012;26(6):926-39.
2012: Sheng Wu; Sara A DiVall; Fredric E Wondisford; Andrew Wolfe
Reproductive tissues maintain insulin sensitivity in diet-induced obesity.
Diabetes 2012;61(1):114-23.
2011: Fredric E Wondisford
A new medical therapy for Cushing disease?
The Journal of clinical investigation 2011;121(12):4621-3.
2011: L A Santiago; Fredric E Wondisford; Carmen C Pazos-Moura; D A Santiago; A Cordeiro; L C Faustino; Patrícia Cristina Lisboa; Tania M Ortiga-Carvalho
The Δ337T mutation on the TRβ causes alterations in growth, adiposity, and hepatic glucose homeostasis in mice.
The Journal of endocrinology 2011;211(1):39-46.
2011: Daniel Diaczok; Sara A DiVall; Isao Matsuo; Fredric E Wondisford; Andrew Wolfe; Sally Radovick
Deletion of Otx2 in GnRH neurons results in a mouse model of hypogonadotropic hypogonadism.
Molecular endocrinology (Baltimore, Md.) 2011;25(5):833-46.
2011: Claus-Peter Richter; Fredric E Wondisford; Adrian Münscher; Danielle Santana Machado; Tania M Ortiga-Carvalho
Complete activation of thyroid hormone receptor β by T3 is essential for normal cochlear function and morphology in mice.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011;28(5):997-1008.
2010: Kathryn J Brothers; Sheng Wu; Sara A DiVall; Marcus R Messmer; C Ronald Kahn; RYAN MILLER; Sally Radovick; Fredric E Wondisford; Andrew Wolfe
Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor.
Cell metabolism 2010;12(3):295-305.
2010: Sara A DiVall; Tameeka R Williams; Sarah E Carver; Linda Koch; Jens C Brüning; C Ronald Kahn; Fredric E Wondisford; Sally Radovick; Andrew Wolfe
Divergent roles of growth factors in the GnRH regulation of puberty in mice.
The Journal of clinical investigation 2010;120(8):2900-9.
2010: Aline Cristina Portella; Fernando Carvalho; Larissa Faustino; Fredric E Wondisford; Tânia Maria Ortiga-Carvalho; Flávia Carvalho Alcantara Gomes
Thyroid hormone receptor beta mutation causes severe impairment of cerebellar development.
Molecular and cellular neurosciences 2010;44(1):68-77.
2010: Jing Wang; Ian C G Weaver; Andrée Gauthier-Fisher; Haoran Wang; Ling He; John Yeomans; Fredric E Wondisford; David R Kaplan; Freda D Miller
CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain.
Developmental cell 2010;18(1):114-25.
2009: Surya P Singh; Andrew Wolfe; Yewade Ng; Sara A DiVall; Colleen Buggs; Jon E Levine; Fredric E Wondisford; Sally Radovick
Impaired estrogen feedback and infertility in female mice with pituitary-specific deletion of estrogen receptor alpha (ESR1).
Biology of reproduction 2009;81(3):488-96.
2009: Manuela Alonso; Charles Goodwin; Xiaohui Liao; Tania Ortiga-Carvalho; Danielle S Machado; Fredric E Wondisford; Samuel Refetoff; Roy E Weiss
In vivo interaction of steroid receptor coactivator (SRC)-1 and the activation function-2 domain of the thyroid hormone receptor (TR) beta in TRbeta E457A knock-in and SRC-1 knockout mice.
Endocrinology 2009;150(8):3927-34.
2009: Danielle S Machado; Amin Sabet; Leticia A Santiago; Aniket Sidhaye; Maria I Chiamolera; Tania M Ortiga-Carvalho; Fredric E Wondisford
A thyroid hormone receptor mutation that dissociates thyroid hormone regulation of gene expression in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(23):9441-6.
2009: Ling He; Amin Sabet; Stephen Djedjos; RYAN MILLER; Xiao Jian Sun; Mehboob A Hussain; Sally Radovick; Fredric E Wondisford
Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein.
Cell 2009;137(4):635-46.
2009: Maria Izabel Chiamolera; Fredric E Wondisford
Minireview: Thyrotropin-releasing hormone and the thyroid hormone feedback mechanism.
Endocrinology 2009;150(3):1091-6.
2009: Norma A S Almeida; Aline Cordeiro; Danielle S Machado; Luciana L Souza; Tania M Ortiga-Carvalho; Antonio C Campos de Carvalho; Fredric E Wondisford; Carmen C Pazos-Moura
Connexin40 messenger ribonucleic acid is positively regulated by thyroid hormone (TH) acting in cardiac atria via the TH receptor.
Endocrinology 2009;150(1):546-54.
2008: Woo-Jin Song; Weston E Schreiber; Enhong Zhong; Fei-Fei Liu; Benjamin D Kornfeld; Fredric E Wondisford; Mehboob A Hussain
Exendin-4 stimulation of cyclin A2 in beta-cell proliferation.
Diabetes 2008;57(9):2371-81.
2008: Kerstin Sinkevicius; Joanna E Burdette; Karolina Woloszyn; Sylvia C Hewitt; Katherine Hamilton; Sonia L Sugg; Karla A Temple; Fredric E Wondisford; Kenneth S Korach; Teresa K Woodruff; Geoffrey L Greene
An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo.
Endocrinology 2008;149(6):2970-9.
2008: Cristiano N Pessôa; Leticia A Santiago; Diana A Santiago; Danielle S Machado; Fernando A F Rocha; Dora Ventura; Jan Nora Hokoç; Carmen C Pazos-Moura; Fredric E Wondisford; Patricia F Gardino; Tania M Ortiga-Carvalho
Thyroid hormone action is required for normal cone opsin expression during mouse retinal development.
Investigative ophthalmology & visual science 2008;49(5):2039-45.
2008: Sara A DiVall; Fredric E Wondisford
TRH testing in its infancy.
The Journal of clinical endocrinology and metabolism 2008;93(2):378-9.
2007: Meredithe L Applebury; F Farhangfar; M Glösmann; Koshi Hashimoto; K Kage; Janet T Robbins; Nobuyuki Shibusawa; Fredric E Wondisford; H Zhang
Transient expression of thyroid hormone nuclear receptor TRbeta2 sets S opsin patterning during cone photoreceptor genesis.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(5):1203-12.
2006: Mehboob A Hussain; Delia L Porras; Matthew H Rowe; Jason R West; Woo-Jin Song; Weston E Schreiber; Fredric E Wondisford
Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation.
Molecular and cellular biology 2006;26(20):7747-59.
2006: Karuna Naik; Isaiah Pittman; Andrew Wolfe; RYAN MILLER; Sally Radovick; Fredric E Wondisford
A novel technique for temporally regulated cell type-specific Cre expression and recombination in the pituitary gonadotroph.
Journal of molecular endocrinology 2006;37(1):63-9.
2006: Colleen Buggs; Frank Weinberg; Ellen Kim; Andrew Wolfe; Sally Radovick; Fredric E Wondisford
Insulin augments GnRH-stimulated LHbeta gene expression by Egr-1.
Molecular and cellular endocrinology 2006;249(1-2):99-106.
2006: Amisra A Nikrodhanond; Tania M Ortiga-Carvalho; Nobuyuki Shibusawa; Koshi Hashimoto; Xiao-Hui Liao; Samuel Refetoff; Masanobu Yamada; Masatomo Mori; Fredric E Wondisford
Dominant role of thyrotropin-releasing hormone in the hypothalamic-pituitary-thyroid axis.
The Journal of biological chemistry 2006;281(8):5000-7.
2006: Fredric E Wondisford
Unlikely partners in weight loss?
Cell metabolism 2006;3(2):81-2.
2006: Koshi Hashimoto; Ronald N Cohen; Masanobu Yamada; Kathleen R Markan; Tsuyoshi Monden; Teturou Satoh; Masatomo Mori; Fredric E Wondisford
Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model.
The Journal of biological chemistry 2006;281(1):295-302.
2006: Ronald N Cohen; Thierry Brue; Karuna Naik; Christine A Houlihan; Fredric E Wondisford; Sally Radovick
The role of CBP/p300 interactions and Pit-1 dimerization in the pathophysiological mechanism of combined pituitary hormone deficiency.
The Journal of clinical endocrinology and metabolism 2006;91(1):239-47.
2005: Tania M Ortiga-Carvalho; Nobuyuki Shibusawa; Amisra A Nikrodhanond; Karen Jesus Oliveira; Danielle S Machado; Xiao-Hui Liao; Ronald N Cohen; Samuel Refetoff; Fredric E Wondisford
Negative regulation by thyroid hormone receptor requires an intact coactivator-binding surface.
The Journal of clinical investigation 2005;115(9):2517-23.
2005: Karla A Temple; Ronald N Cohen; Sarah R Wondisford; Christine Yu; Dianne Deplewski; Fredric E Wondisford
An intact DNA-binding domain is not required for peroxisome proliferator-activated receptor gamma (PPARgamma) binding and activation on some PPAR response elements.
The Journal of biological chemistry 2005;280(5):3529-40.
2005: Koshi Hashimoto; Masanobu Yamada; Tsuyoshi Monden; Teturou Satoh; Fredric E Wondisford; Masatomo Mori
Thyrotropin-releasing hormone (TRH) specific interaction between amino terminus of P-Lim and CREB binding protein (CBP).
Molecular and cellular endocrinology 2005;229(1-2):11-20.
2004: Xiao Yan Zhou; Nobuyuki Shibusawa; Karuna Naik; Delia Porras; Karla A Temple; Hesheng Ou; Kelly Kaihara; Michael W Roe; Matthew J Brady; Fredric E Wondisford
Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein.
Nature medicine 2004;10(6):633-7.
2004: Tania M Ortiga-Carvalho; Koshi Hashimoto; Carmen C Pazos-Moura; David L Geenen; Ronald Cohen; Roberto M Lang; Fredric E Wondisford
Thyroid hormone resistance in the heart: role of the thyroid hormone receptor beta isoform.
Endocrinology 2004;145(4):1625-33.
2003: E Dale Abel; Egberto Moura; Rexford S Ahima; Angel Campos-Barros; Carmen C Pazos-Moura; Mary-Ellen Boers; Helen C Kaulbach; Douglas Forrest; Fredric E Wondisford
Dominant inhibition of thyroid hormone action selectively in the pituitary of thyroid hormone receptor-beta null mice abolishes the regulation of thyrotropin by thyroid hormone.
Molecular endocrinology (Baltimore, Md.) 2003;17(9):1767-76.
2003: Nobuyuki Shibusawa; Koshi Hashimoto; Amisra A Nikrodhanond; M Charles Liberman; Meredithe L Applebury; Xiao-Hui Liao; Janet T Robbins; Samuel Refetoff; Ronald N Cohen; Fredric E Wondisford
Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo.
The Journal of clinical investigation 2003;112(4):588-97.
2003: Fredric E Wondisford
Thyroid hormone action: insight from transgenic mouse models.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2003;51(4):215-20.
2003: Tsuyoshi Monden; Masanobu Yamada; Sumiyasu Ishii; Takeshi Hosoya; Teturo Satoh; Fredric E Wondisford; Anthony N Hollenberg; Masatomo Mori
Leucine at codon 428 in the ninth heptad of thyroid hormone receptor beta1 is necessary for interactions with the transcriptional cofactors and functions regardless of dimer formations.
Thyroid : official journal of the American Thyroid Association 2003;13(5):427-35.
2003: Nobuyuki Shibusawa; Anthony N Hollenberg; Fredric E Wondisford
Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation.
The Journal of biological chemistry 2003;278(2):732-8.
2002: Fredric E Wondisford
The thyroid axis just got more complicated.
The Journal of clinical investigation 2002;109(11):1401-2.
2001: Ronald N Cohen; Sabrina Brzostek; Brian W. Kim; M Chorev; Fredric E Wondisford; Anthony N Hollenberg
The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains.
Molecular endocrinology (Baltimore, Md.) 2001;15(7):1049-61.
2001: E Dale Abel; Rexford S Ahima; Mary-Ellen Boers; J K Elmquist; Fredric E Wondisford
Critical role for thyroid hormone receptor beta2 in the regulation of paraventricular thyrotropin-releasing hormone neurons.
The Journal of clinical investigation 2001;107(8):1017-23.
2001: K Hashimoto; Flavio Henrique Curty; PP Borges; C E Lee; E Dale Abel; J K Elmquist; Ronald N Cohen; Fredric E Wondisford
An unliganded thyroid hormone receptor causes severe neurological dysfunction.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):3998-4003.
2001: K Zanger; Sally Radovick; Fredric E Wondisford
CREB binding protein recruitment to the transcription complex requires growth factor-dependent phosphorylation of its GF box.
Molecular cell 2001;7(3):551-8.
2001: Joshua Safer; S D Colan; Lisa M Fraser; Fredric E Wondisford
A pituitary tumor in a patient with thyroid hormone resistance: a diagnostic dilemma.
Thyroid : official journal of the American Thyroid Association 2001;11(3):281-91.
2001: J Pachucki; J Hopkins; R Peeters; H Tu; Suzy Bianco; Helen C Kaulbach; E Dale Abel; Fredric E Wondisford; Joanne S Ingwall; P Reed Larsen
Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis.
Endocrinology 2001;142(1):13-20.
2000: K Hashimoto; K Zanger; Anthony N Hollenberg; Laurie E Cohen; Sally Radovick; Fredric E Wondisford
cAMP response element-binding protein-binding protein mediates thyrotropin-releasing hormone signaling on thyrotropin subunit genes.
The Journal of biological chemistry 2000;275(43):33365-72.
2000: Ronald N Cohen; A Putney; Fredric E Wondisford; Anthony N Hollenberg
The nuclear corepressors recognize distinct nuclear receptor complexes.
Molecular endocrinology (Baltimore, Md.) 2000;14(6):900-14.
2000: Carmen C Pazos-Moura; E Dale Abel; Mary-Ellen Boers; Egberto Moura; T G Hampton; J Wang; J P Morgan; Fredric E Wondisford
Cardiac dysfunction caused by myocardium-specific expression of a mutant thyroid hormone receptor.
Circulation research 2000;86(6):700-6.
2000: C Oberste-Berghaus; K Zanger; K Hashimoto; Ronald N Cohen; Anthony N Hollenberg; Fredric E Wondisford
Thyroid hormone-independent interaction between the thyroid hormone receptor beta2 amino terminus and coactivators.
The Journal of biological chemistry 2000;275(3):1787-92.
1999: Laurie E Cohen; Y Hashimoto; K Zanger; Fredric E Wondisford; Sally Radovick
CREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expression.
The Journal of clinical investigation 1999;104(8):1123-30.
1999: Tsuyoshi Monden; Mikiko Kishi; T Hosoya; Teturou Satoh; Fredric E Wondisford; Anthony N Hollenberg; Masanobu Yamada; Masatomo Mori
p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers.
Molecular endocrinology (Baltimore, Md.) 1999;13(10):1695-703.
1999: Joshua Safer; M G O'Connor; S D Colan; S Srinivasan; S R Tollin; Fredric E Wondisford
The thyroid hormone receptor-beta gene mutation R383H is associated with isolated central resistance to thyroid hormone.
The Journal of clinical endocrinology and metabolism 1999;84(9):3099-109.
1999: E Dale Abel; Mary-Ellen Boers; Carmen C Pazos-Moura; Egberto Moura; Helen C Kaulbach; M Zakaria; B Lowell; Sally Radovick; M C Liberman; Fredric E Wondisford
Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system.
The Journal of clinical investigation 1999;104(3):291-300.
1999: Laurie E Cohen; K Zanger; Thierry Brue; Fredric E Wondisford; Sally Radovick
Defective retinoic acid regulation of the Pit-1 gene enhancer: a novel mechanism of combined pituitary hormone deficiency.
Molecular endocrinology (Baltimore, Md.) 1999;13(3):476-84.
1999: K Zanger; Laurie E Cohen; K Hashimoto; Sally Radovick; Fredric E Wondisford
A novel mechanism for cyclic adenosine 3',5'-monophosphate regulation of gene expression by CREB-binding protein.
Molecular endocrinology (Baltimore, Md.) 1999;13(2):268-75.
1999: E Dale Abel; Helen C Kaulbach; Angel Campos-Barros; Rexford S Ahima; Mary-Ellen Boers; K Hashimoto; Douglas Forrest; Fredric E Wondisford
Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin.
The Journal of clinical investigation 1999;103(2):271-9.
1998: Joshua Safer; Ronald N Cohen; Anthony N Hollenberg; Fredric E Wondisford
Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone.
The Journal of biological chemistry 1998;273(46):30175-82.
1998: Ronald N Cohen; Fredric E Wondisford; Anthony N Hollenberg
Two separate NCoR (nuclear receptor corepressor) interaction domains mediate corepressor action on thyroid hormone response elements.
Molecular endocrinology (Baltimore, Md.) 1998;12(10):1567-81.
1998: Sally Radovick; Laurie E Cohen; Fredric E Wondisford
The molecular basis of hypopituitarism.
Hormone research 1998;49 Suppl 1():30-6.
1997: T Monden; Fredric E Wondisford; Anthony N Hollenberg
Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein.
The Journal of biological chemistry 1997;272(47):29834-41.
1997: M F Langlois; K Zanger; T Monden; Joshua Safer; Anthony N Hollenberg; Fredric E Wondisford
A unique role of the beta-2 thyroid hormone receptor isoform in negative regulation by thyroid hormone. Mapping of a novel amino-terminal domain important for ligand-independent activation.
The Journal of biological chemistry 1997;272(40):24927-33.
1997: Paul W Ladenson; Lewis E Braverman; Ernest L Mazzaferri; Françoise Brucker-Davis; David S Cooper; J R Garber; Fredric E Wondisford; terry Davies; L J DeGroot; Gilbert H Daniels; Douglas S Ross; Bruce D Weintraub
Comparison of administration of recombinant human thyrotropin with withdrawal of thyroid hormone for radioactive iodine scanning in patients with thyroid carcinoma.
The New England journal of medicine 1997;337(13):888-96.
1997: G Medeiros-Neto; L de Lacerda; Fredric E Wondisford
Familial Congenital Hypothyroidism Caused by Abnormal and Bioinactive TSH due to Mutations in the beta-Subunit Gene.
Trends in endocrinology and metabolism: TEM 1997;8(1):15-20.
1997: Hans Jürgen Steinfelder; Fredric E Wondisford
Thyrotropin (TSH) beta-subunit gene expression--an example for the complex regulation of pituitary hormone genes.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1997;105(4):196-203.
1997: Joshua Safer; M F Langlois; R Cohen; T Monden; D John-Hope; J Madura; Anthony N Hollenberg; Fredric E Wondisford
Isoform variable action among thyroid hormone receptor mutants provides insight into pituitary resistance to thyroid hormone.
Molecular endocrinology (Baltimore, Md.) 1997;11(1):16-26.
1996: Fredric E Wondisford
Thyroid hormone action beyond the receptor.
The Journal of clinical endocrinology and metabolism 1996;81(12):4194-5.
1996: Anthony N Hollenberg; Tsuyoshi Monden; J P Madura; K Lee; Fredric E Wondisford
Function of nuclear co-repressor protein on thyroid hormone response elements is regulated by the receptor A/B domain.
The Journal of biological chemistry 1996;271(45):28516-20.
1996: Laurie E Cohen; Fredric E Wondisford; Sally Radovick
Role of Pit-1 in the gene expression of growth hormone, prolactin, and thyrotropin.
Endocrinology and metabolism clinics of North America 1996;25(3):523-40.
1996: G Medeiros-Neto; D T Herodotou; S Rajan; S Kommareddi; L de Lacerda; Romolo Sandrini; M C Boguszewski; Anthony N Hollenberg; Sally Radovick; Fredric E Wondisford
A circulating, biologically inactive thyrotropin caused by a mutation in the beta subunit gene.
The Journal of clinical investigation 1996;97(5):1250-6.
1995: L Joshi; Y Murata; Fredric E Wondisford; Mariusz Szkudlinski; R Desai; Bruce D Weintraub
Recombinant thyrotropin containing a beta-subunit chimera with the human chorionic gonadotropin-beta carboxy-terminus is biologically active, with a prolonged plasma half-life: role of carbohydrate in bioactivity and metabolic clearance.
Endocrinology 1995;136(9):3839-48.
1995: Anthony N Hollenberg; Tsuyoshi Monden; Fredric E Wondisford
Ligand-independent and -dependent functions of thyroid hormone receptor isoforms depend upon their distinct amino termini.
The Journal of biological chemistry 1995;270(24):14274-80.
1995: O Cohen; T R Flynn; Fredric E Wondisford
Ligand-dependent antagonism by retinoid X receptors of inhibitory thyroid hormone response elements.
The Journal of biological chemistry 1995;270(23):13899-905.
1995: Anthony N Hollenberg; Tsuyoshi Monden; T R Flynn; M E Boers; O Cohen; Fredric E Wondisford
The human thyrotropin-releasing hormone gene is regulated by thyroid hormone through two distinct classes of negative thyroid hormone response elements.
Molecular endocrinology (Baltimore, Md.) 1995;9(5):540-50.
1995: Laurie E Cohen; Fredric E Wondisford; A Salvatoni; M Maghnie; F Brucker-Davis; Bruce D Weintraub; Sally Radovick
A "hot spot" in the Pit-1 gene responsible for combined pituitary hormone deficiency: clinical and molecular correlates.
The Journal of clinical endocrinology and metabolism 1995;80(2):679-84.
1994: T R Flynn; Anthony N Hollenberg; O Cohen; J B Menke; stephen usala; S Tollin; M K Hegarty; Fredric E Wondisford
A novel C-terminal domain in the thyroid hormone receptor selectively mediates thyroid hormone inhibition.
The Journal of biological chemistry 1994;269(52):32713-6.
1994: Sally Radovick; S Wray; L Muglia; H Westphal; B Olsen; E Smith; E Patriquin; Fredric E Wondisford
Steroid hormone regulation and tissue-specific expression of the human GnRH gene in cell culture and transgenic animals.
Hormones and behavior 1994;28(4):520-9.
1993: Fredric E Wondisford; Hans Jürgen Steinfelder; M Nations; Sally Radovick
AP-1 antagonizes thyroid hormone receptor action on the thyrotropin beta-subunit gene.
The Journal of biological chemistry 1993;268(4):2749-54.
1992: Sally Radovick; M Nations; Y Du; L A Berg; Bruce D Weintraub; Fredric E Wondisford
A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency.
Science (New York, N.Y.) 1992;257(5073):1115-8.
1992: Hans Jürgen Steinfelder; Sally Radovick; Fredric E Wondisford
Hormonal regulation of the thyrotropin beta-subunit gene by phosphorylation of the pituitary-specific transcription factor Pit-1.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):5942-5.
1992: Robert W Lash; R K Desai; C A Zimmerman; M R Flack; T Yoshida; Fredric E Wondisford; Bruce D Weintraub
Mutations of the human thyrotropin-beta subunit glycosylation site reduce thyrotropin synthesis independent of changes in glycosylation status.
Journal of endocrinological investigation 1992;15(4):255-63.
1992: Hans Jürgen Steinfelder; Sally Radovick; M A Mroczynski; Peter Hauser; J H McClaskey; Bruce D Weintraub; Fredric E Wondisford
Role of a pituitary-specific transcription factor (pit-1/GHF-1) or a closely related protein in cAMP regulation of human thyrotropin-beta subunit gene expression.
The Journal of clinical investigation 1992;89(2):409-19.
1991: D L Bodenner; M A Mroczynski; Bruce D Weintraub; Sally Radovick; Fredric E Wondisford
A detailed functional and structural analysis of a major thyroid hormone inhibitory element in the human thyrotropin beta-subunit gene.
The Journal of biological chemistry 1991;266(32):21666-73.
1991: Sally Radovick; C M Ticknor; Y Nakayama; A C Notides; A Rahman; Bruce D Weintraub; G B Cutler; Fredric E Wondisford
Evidence for direct estrogen regulation of the human gonadotropin-releasing hormone gene.
The Journal of clinical investigation 1991;88(5):1649-55.
1991: Sally Radovick; S Wray; E Lee; D K Nicols; Y Nakayama; Bruce D Weintraub; H Westphal; G B Cutler; Fredric E Wondisford
Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3402-6.
1991: Hans Jürgen Steinfelder; Peter Hauser; Y Nakayama; Sally Radovick; J H McClaskey; T Taylor; Bruce D Weintraub; Fredric E Wondisford
Thyrotropin-releasing hormone regulation of human TSHB expression: role of a pituitary-specific transcription factor (Pit-1/GHF-1) and potential interaction with a thyroid hormone-inhibitory element.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(8):3130-4.
1991: stephen usala; J B Menke; T L Watson; Fredric E Wondisford; Bruce D Weintraub; J Bérard; W E Bradley; S Ono; O T Mueller; Barry B Bercu
A homozygous deletion in the c-erbA beta thyroid hormone receptor gene in a patient with generalized thyroid hormone resistance: isolation and characterization of the mutant receptor.
Molecular endocrinology (Baltimore, Md.) 1991;5(3):327-35.
1991: M Yamada; Fredric E Wondisford; Sally Radovick; Y Nakayama; Bruce D Weintraub; JF Wilber
Assignment of human preprothyrotropin-releasing hormone (TRH) gene to chromosome 3.
Somatic cell and molecular genetics 1991;17(1):97-100.
1990: stephen usala; Fredric E Wondisford; T L Watson; J B Menke; Bruce D Weintraub
Thyroid hormone and DNA binding properties of a mutant c-erbA beta receptor associated with generalized thyroid hormone resistance.
Biochemical and biophysical research communications 1990;171(2):575-80.
1990: Y Nakayama; Fredric E Wondisford; Robert W Lash; Allen E Bale; Bruce D Weintraub; G B Cutler; Sally Radovick
Analysis of gonadotropin-releasing hormone gene structure in families with familial central precocious puberty and idiopathic hypogonadotropic hypogonadism.
The Journal of clinical endocrinology and metabolism 1990;70(5):1233-8.
1990: M Yamada; Sally Radovick; Fredric E Wondisford; Y Nakayama; Bruce D Weintraub; JF Wilber
Cloning and structure of human genomic DNA and hypothalamic cDNA encoding human prepro thyrotropin-releasing hormone.
Molecular endocrinology (Baltimore, Md.) 1990;4(4):551-6.
1990: Sally Radovick; Fredric E Wondisford; Y Nakayama; M Yamada; G B Cutler; Bruce D Weintraub
Isolation and characterization of the human gonadotropin-releasing hormone gene in the hypothalamus and placenta.
Molecular endocrinology (Baltimore, Md.) 1990;4(3):476-80.
1990: stephen usala; G E Tennyson; Allen E Bale; Robert W Lash; N Gesundheit; Fredric E Wondisford; D Accili; Peter Hauser; Bruce D Weintraub
A base mutation of the C-erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance. Molecular heterogeneity in two other kindreds.
The Journal of clinical investigation 1990;85(1):93-100.
1990: Bruce D Weintraub; Fredric E Wondisford; E A Farr; Hans Jürgen Steinfelder; Sally Radovick; N Gesundheit; P W Gyves; T Taylor; George Decherney
Pre-translational and post-translational regulation of TSH: relationship to bioactivity.
Hormone and metabolic research. Supplement series 1990;23():9-11.
1990: T Taylor; Fredric E Wondisford; T Blaine; Bruce D Weintraub
The paraventricular nucleus of the hypothalamus has a major role in thyroid hormone feedback regulation of thyrotropin synthesis and secretion.
Endocrinology 1990;126(1):317-24.
1989: Fredric E Wondisford; E A Farr; Sally Radovick; Hans Jürgen Steinfelder; J M Moates; J H McClaskey; Bruce D Weintraub
Thyroid hormone inhibition of human thyrotropin beta-subunit gene expression is mediated by a cis-acting element located in the first exon.
The Journal of biological chemistry 1989;264(25):14601-4.
1989: H Kadowaki; T Kadowaki; Fredric E Wondisford; Simeon I Taylor
Use of polymerase chain reaction catalyzed by Taq DNA polymerase for site-specific mutagenesis.
Gene 1989;76(1):161-6.
1989: Bruce D Weintraub; Fredric E Wondisford; E A Farr; Hans Jürgen Steinfelder; Sally Radovick; N Gesundheit; P W Gyves; T Taylor; George Decherney
Pre-translational and post-translational regulation of TSH synthesis in normal and neoplastic thyrotrophs.
Hormone research 1989;32(1-3):22-4.
1988: stephen usala; Allen E Bale; N Gesundheit; C Weinberger; Robert W Lash; Fredric E Wondisford; O W McBride; Bruce D Weintraub
Tight linkage between the syndrome of generalized thyroid hormone resistance and the human c-erbA beta gene.
Molecular endocrinology (Baltimore, Md.) 1988;2(12):1217-20.
1988: Fredric E Wondisford; Sally Radovick; J M Moates; stephen usala; Bruce D Weintraub
Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species.
The Journal of biological chemistry 1988;263(25):12538-42.
1988: Fredric E Wondisford; stephen usala; George Decherney; M Castren; Sally Radovick; P W Gyves; J P Trempe; B P Kerfoot; Vera M Nikodem; Barbara J Carter
Cloning of the human thyrotropin beta-subunit gene and transient expression of biologically active human thyrotropin after gene transfection.
Molecular endocrinology (Baltimore, Md.) 1988;2(1):32-9.
1985: David Kaetzel; J K Browne; Fredric E Wondisford; T M Nett; A R Thomason; John H Nilson
Expression of biologically active bovine luteinizing hormone in Chinese hamster ovary cells.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(21):7280-3.
1985: W A Price; D A Hoffman; L Woods; Fredric E Wondisford; S Zlotnick
Pericarditis associated with Crohn's disease.
The Ohio State medical journal 1985;81(6):429-31.