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Kwok-Kin Wong

Research Profile

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Anatomy

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Sara C Hanna; Sean T Bailey; Lyn M Duncan; Bhavani Krishnan; Pei-Fen Kuan; C Ryan Miller; Stergios J Moschos; E Tim O'Brien; Lukas D Osborne; Takeshi Shimamura; Marni B Siegel; M Celeste Simon; Richard Superfine; Kwok-Kin Wong; William Y Kim
HIF1α and HIF2α independently activate SRC to promote melanoma metastases.
Zuoxiang Xiao; Howard A Young; Feng Zhu; Timothy Back; Sandra Burkett; Travis Cohoon; Mahesh Datla; Romina Goldszmid; Qun Jiang; Fanching Lin; Kristen Pike; David S Schrump; Na-Young Song; Zhonghe Sun; Giorgio Trinchieri; Jami Willette-Brown; Robert H Wiltrout; Kwok-Kin Wong; Xiaolin Wu; Sichuan Xi; Yinling Hu
The Pivotal Role of IKKα in the Development of Spontaneous Lung Squamous Cell Carcinomas.
Lynette M Sholl; Stanislawa Weremowicz; Kwok-Kin Wong; Lucian R Chirieac; Stacy W Gray; Neal Lindeman; Jason L Hornick
Combined use of ALK immunohistochemistry and FISH for optimal detection of ALK-rearranged lung adenocarcinomas.

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2013: Sara C Hanna; Sean T Bailey; Lyn M Duncan; Bhavani Krishnan; Pei-Fen Kuan; C Ryan Miller; Stergios J Moschos; E Tim O'Brien; Lukas D Osborne; Takeshi Shimamura; Marni B Siegel; M Celeste Simon; Richard Superfine; Kwok-Kin Wong; William Y Kim
HIF1α and HIF2α independently activate SRC to promote melanoma metastases.
The Journal of clinical investigation 2013;123(5):2078-93.
2013: Zuoxiang Xiao; Howard A Young; Feng Zhu; Timothy Back; Sandra Burkett; Travis Cohoon; Mahesh Datla; Romina Goldszmid; Qun Jiang; Fanching Lin; Kristen Pike; David S Schrump; Na-Young Song; Zhonghe Sun; Giorgio Trinchieri; Jami Willette-Brown; Robert H Wiltrout; Kwok-Kin Wong; Xiaolin Wu; Sichuan Xi; Yinling Hu
The Pivotal Role of IKKα in the Development of Spontaneous Lung Squamous Cell Carcinomas.
Cancer cell 2013;23(4):527-40.
2013: Lynette M Sholl; Stanislawa Weremowicz; Kwok-Kin Wong; Lucian R Chirieac; Stacy W Gray; Neal Lindeman; Jason L Hornick
Combined use of ALK immunohistochemistry and FISH for optimal detection of ALK-rearranged lung adenocarcinomas.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2013;8(3):322-8.
2013: Alexandros Tzatsos; Kwok-Kin Wong; Gianmarco Contino; Vikram Deshpande; Francesco Ferrari; Fei Lan; Peter J Park; Polina Paskaleva; Svetlana Stoykova; Patrick Trojer; Nabeel Bardeesy
KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.
The Journal of clinical investigation 2013;123(2):727-39.
2013: Nicole L Solimini; Kwok-Kin Wong; Chunxiao Xu; Qikai Xu; Teresa Davoli; Mamie Z Li; Anthony C Liang; Natalya N Pavlova; Stephen J Elledge
STOP gene Phactr4 is a tumor suppressor.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(5):E407-14.
2013: Alexis B Cortot; Dalia Ercan; Nathanael S Gray; Claire E Repellin; Takeshi Shimamura; Kwok-Kin Wong; Kreshnik Zejnullahu; Marzia Capelletti; James G Christensen; Pasi A Janne
Resistance to irreversible EGF receptor tyrosine kinase inhibitors through a multistep mechanism involving the IGF1R pathway.
Cancer research 2013;73(2):834-43.
2013: Ryan B Corcoran; Dora Dias-Santagata; Hiromichi Ebi; Cyril H Benes; Ronald D Brown; Katherine A Cheng; Erin M Coffee; Travis J Cohoon; Anthony C Faber; Jason T Godfrey; Patricia Greninger; Aaron N Hata; Kenneth E Hung; Eugene Lifshits; Mari Mino-Kenudson; Jeffrey Settleman; Toshi Shioda; Anurag Singh; Youngchul Song; Kwok-Kin Wong; Jeffrey A Engelman
Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models.
Cancer cell 2013;23(1):121-8.
2013: Grit S Herter-Sprie; Heidi Greulich; Kwok-Kin Wong
Activating Mutations in ERBB2 and Their Impact on Diagnostics and Treatment.
Frontiers in oncology 2013;3():86.
2012: Yan Feng; Yijun Gao; Nabeel Bardeesy; Haiquan Chen; Zhaoyuan Fang; Fei Li; Fuming Li; Hongyan Liu; Xiaolong Liu; Yihua Sun; Ye Wang; Zuoyun Wang; Kwok-Kin Wong; Tian Xiao; Zhi-qi Xiong; Qiwei Zhai; Yang Zhou; Hongbin Ji
The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss.
Cancer research 2012;72(24):6502-11.
2012: Zoë Weaver; Kwok-Kin Wong; Danny Alexander; Fatima Al-Shahrour; Maureen Baran; Julian Carretero; Simone Difilippantonio; Rajaa El Meskini; Theresa Guerin; Michelle Gumprecht; Anthony J Iacovelli; Serguei Kozlov; Alan Kulaga; Philip L Martin; Thomas McCann; Salvador Mena; Jerome Schlomer; Terry Van Dyke
Temporal molecular and biological assessment of an erlotinib-resistant lung adenocarcinoma model reveals markers of tumor progression and treatment response.
Cancer research 2012;72(22):5921-33.
2012: Dalia Ercan; Levi A Garraway; Eva M Goetz; Nathanael S Gray; Elena V Ivanova; Mohit Butaney; Marzia Capelletti; Matthew J Lazzara; Anthony Letai; Ophélia Maertens; Calixte S Monast; Joan Montero; Christine A Pratilas; Claire Repellin; Andrew Rogers; Neal Rosen; Takeshi Shimamura; Lynette Sholl; Madhavi Tadi; Kwok-Kin Wong; Chunxiao Xu; Masahiko Yanagita; Pasi A Janne
Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.
Cancer discovery 2012;2(10):934-47.
2012: Takeshi Shimamura; Papiya Sinha; Kwok-Kin Wong; Weiwen Ying; James Barsoum; Christa L Borgman; Christopher D Carey; Julian Carretero; Liang Chen; Kevin P Foley; Takayo Inoue; John-Paul Jimenez; Danan Li; Yu-Chen Li; Matthew Meyerson; Samanthi A Perera; Scott J Rodig; Jim Sang; Geoffrey I Shapiro
Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(18):4973-85.
2012: Heidi Greulich; William C Hahn; Marcin Imielinski; Jacob D Jaffe; Bethany Kaplan; Michael S Lawrence; Se-Hoon Lee; Rachel Liao; D R Mani; Philipp Mertins; Lauren Ambrogio; Shantanu Banerji; Alice H Berger; Steven A Carr; Tzu-Hsiu Chen; Jeonghee Cho; Michael J Eck; David Frank; Gad Getz; Nam H Pho; Kumiko E Tanaka; Sarah R Walker; Wendy Winckler; Kwok-Kin Wong; Cai-Hong Yun; Jinghui Zhang; Xiaohong Zhang; Matthew Meyerson
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(36):14476-81.
2012: Lu Xu; Chunxiao Xu; Katherine A Cheng; Hiromichi Ebi; Jeffrey A Engelman; Dalia Ercan; Pasi A Janne; Eiki Kikuchi; Robert F Padera; Geoffrey I Shapiro; Takeshi Shimamura; Kwok-Kin Wong
Combined EGFR/MET or EGFR/HSP90 inhibition is effective in the treatment of lung cancers codriven by mutant EGFR containing T790M and MET.
Cancer research 2012;72(13):3302-11.
2012: Wenjin Liu; C Ryan Miller; Kimberly B Monahan; David W Ollila; Charles M Perou; Adam D Pfefferle; David W Roadcap; Takeshi Shimamura; Jessica Sorrentino; Nancy E Thomas; Kwok-Kin Wong; James E Bear; Diego H Castrillon; Keefe T Chan; Norman E Sharpless
LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma.
Cancer cell 2012;21(6):751-64.
2012: Oddbjørn Straume; Souming Wang; Randolph S Watnick; Kwok-Kin Wong; Anne Margrete Oyan; Geoffrey I Shapiro; Takeshi Shimamura; Sarah M Short; Margaret Soucheray; Lars A Akslen; Ingeborg Bachmann; Christa L Borgman; Julian Carretero; Liang Chen; Karin Collett; Sean R Downing; Judah Folkman; Di Jia; Karl-Henning Kalland; Soo-Young Kang; Michael J G Lampa; George N Naumov
Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(22):8699-704.
2012: Kavita Bhalla; Shyam Biswal; Ruby E Dewi; Olga Goloubeva; Bor-Jang Hwang; Neeraj Saxena; William Twaddel; Kwok-Kin Wong; Geoffrey D Girnun
Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis.
Cancer prevention research (Philadelphia, Pa.) 2012;5(4):544-52.
2012: Patrick J Roberts; John E Bisi; Austin J Combest; David B Darr; Charles M Perou; Jay C Strum; Jerry E Usary; Kwok-Kin Wong; William C Zamboni; Norman E Sharpless
Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy.
Journal of the National Cancer Institute 2012;104(6):476-87.
2012: Zuoyun Wang; Kwok-Kin Wong; Nabeel Bardeesy; Nabeel Bardessy; Yan Feng; Xin-Yuan Liu; Hongbin Ji
Temporal dissection of K-ras(G12D) mutant in vitro and in vivo using a regulatable K-ras(G12D) mouse allele.
PloS one 2012;7(5):e37308.
2011: Hiromichi Ebi; Cyril Benes; Lewis C Cantley; Zhao Chen; Ryan B Corcoran; Eugene Lifshits; Jeffrey A Meyerhardt; David P Ryan; Jeffrey Settleman; Anurag Singh; Youngchul Song; Kwok-Kin Wong; Jeffrey A Engelman
Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers.
The Journal of clinical investigation 2011;121(11):4311-21.
2011: Yen-Tsung Huang; Xihong Lin; Yan Liu; Ray McGovern; Vidar Skaug; Li Su; John Wain; Kwok-Kin Wong; Shanbeh Zienolddiny; Lucian R Chirieac; Edward A Fox; Aage Haugen; Rebecca Heist; David C Christiani
Cigarette smoking increases copy number alterations in nonsmall-cell lung cancer.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(39):16345-50.
2011: Alexandros Tzatsos; Kwok-Kin Wong; Zhao Chen; Gianmarco Contino; Stephania Lymperi; Polina Paskaleva; Svetlana Stoykova; Nabeel Bardeesy
Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells.
The Journal of biological chemistry 2011;286(38):33061-9.
2011: Takaaki Sasaki; Takeshi Shimamura; Magda Stumpfova; Stanislawa Weremowicz; Keith Wilner; Kwok-Kin Wong; Yun Xiao; Masahiko Yanagita; Wei Zheng; Mohit Butaney; Marzia Capelletti; James G Christensen; Jinyan Du; Michael J Eck; Dalia Ercan; Nathanael S Gray; Stephanie Heon; Jussi Koivunen; Christopher Lathan; Neal Lindeman; J Paul Marcoux; Sarah Nikiforow; Atsuko Ogino; Katsuhiro Okuda; Scott J Rodig; Pasi A Janne
A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors.
Cancer research 2011;71(18):6051-60.
2011: Thomas De Raedt; Marcia C Haigis; Seung Min Jeong; Raghu Kalluri; Valerie Lebleu; Danan Li; Kay F Macleod; Ophélia Maertens; Clare F Malone; Brendan D Manning; Emmanuel Normant; Zandra Walton; Kwok-Kin Wong; Jessica L Yecies; Roderick T Bronson; Yimei Chen; Karen Cichowski
Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.
Cancer cell 2011;20(3):400-13.
2011: Kwon-Sik Park; David M Raiser; Rebecca R Roach; Caitlin M Roake; Julien Sage; Bethany E Schaffer; Zandra Walton; Kwok-Kin Wong; Raffaella Zamponi; Anne-Flore Zmoos; Stephen J Curtis; Christina Kriegel; Mei-Chih Liang; Carla F Kim
Characterization of the cell of origin for small cell lung cancer.
Cell cycle (Georgetown, Tex.) 2011;10(16):2806-15.
2011: Neil Johnson; Danan Li; Yu-Chen Li; Lisa A Moreau; David R Newell; Scott J Rodig; Roderick T Bronson; Katherine A Cheng; Nicola J Curtin; Alan D D'Andrea; Huw D Thomas; Christine Unitt; Zandra E Walton; Kwok-Kin Wong; Geoffrey I Shapiro
Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.
Nature medicine 2011;17(7):875-82.
2011: Michael Dougan; Danan Li; Donna Neuberg; Martin Mihm; Paul Googe; Kwok-Kin Wong; Glenn Dranoff
A dual role for the immune response in a mouse model of inflammation-associated lung cancer.
The Journal of clinical investigation 2011;121(6):2436-46.
2011: Joseph Rosenbluh; Kwok-Kin Wong; Zhao Chen; Kenkichi Masutomi; Deepak Nijhawan; William C Hahn
RMRP is a non-coding RNA essential for early murine development.
PloS one 2011;6(10):e26270.
2010: Zhao Chen; Takaaki Sasaki; Xiaohong Tan; Julian Carretero; Takeshi Shimamura; Danan Li; Chunxiao Xu; Yuchuan Wang; Guillaume O Adelmant; Marzia Capelletti; Hyun Joo Lee; Scott J Rodig; Christa Borgman; Seung-Il Park; Hyeong Ryul Kim; Robert F Padera; Jarrod A Marto; Nathanael S Gray; Andrew L Kung; Geoffrey I Shapiro; Pasi A Janne; Kwok-Kin Wong
Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene.
Cancer research 2010;70(23):9827-36.
2010: Yijun Gao; Qian Xiao; HuiMin Ma; Li Li; Jun Liu; Yan Feng; Zhaoyuan Fang; Jing Wu; Xiangkun Han; Junhua Zhang; Yihua Sun; Gongwei Wu; Robert Padera; Haiquan Chen; Kwok-Kin Wong; Gaoxiang Ge; Hongbin Ji
LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(44):18892-7.
2010: Stephen J Curtis; Kerstin W Sinkevicius; Danan Li; Allison N Lau; Rebecca R Roach; Raffaella Zamponi; Amber E Woolfenden; David G Kirsch; Kwok-Kin Wong; Carla F. Kim
Primary tumor genotype is an important determinant in identification of lung cancer propagating cells.
Cell stem cell 2010;7(1):127-33.
2010: Søren M Johnson; Chad D Torrice; Jessica F Bell; Kimberly B Monahan; Qi Jiang; Yong Wang; Matthew Robert Ramsey; Jian Jin; Kwok-Kin Wong; Lishan Su; Daohong Zhou; Norman E Sharpless
Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.
The Journal of clinical investigation 2010;120(7):2528-36.
2010: Julian Carretero; Takeshi Shimamura; Klarisa Rikova; Autumn L Jackson; Matthew D Wilkerson; Christa L Borgman; Matthew S Buttarazzi; Benjamin A Sanofsky; Kate McNamara; Kathleyn A Brandstetter; Zandra E Walton; Ting-Lei Gu; Jeffrey C Silva; Katherine Crosby; Geoffrey I Shapiro; Sauveur-Michel Maira; Hongbin Ji; Diego H Castrillon; Carla F Kim; Carlos García-Echeverría; Nabeel Bardeesy; Norman E Sharpless; Neil D Hayes; William Y Kim; Jeffrey A Engelman; Kwok-Kin Wong
Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.
Cancer cell 2010;17(6):547-59.
2010: Jer-Yen Yang; Chun-Ju Chang; Weiya Xia; Yan Wang; Kwok-Kin Wong; Jeffrey A Engelman; Yi Du; Michael Andreeff; Gabriel N Hortobagyi; Mien-Chie Hung
Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer.
Cancer research 2010;70(11):4709-18.
2010: Sreenath V Sharma; Diana Y Lee; Bihua Li; Margaret P Quinlan; Fumiyuki Takahashi; Shyamala Maheswaran; Ultan McDermott; Nancy Azizian; Lee Zou; Michael A Fischbach; Kwok-Kin Wong; Kathleyn Brandstetter; Ben Wittner; Sridhar Ramaswamy; Marie Classon; Jeffrey Settleman
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations.
Cell 2010;141(1):69-80.
2010: Kwok-Kin Wong; Tyler Jacks; Glenn Dranoff
NF-kappaB fans the flames of lung carcinogenesis.
Cancer prevention research (Philadelphia, Pa.) 2010;3(4):403-5.
2010: Birgit Schoeberl; Anthony C Faber; Danan Li; Mei-Chih Liang; Katherine Crosby; Matthew Onsum; Olga Burenkova; Emily Pace; Zandra Walton; Lin Nie; Aaron Fulgham; Youngchul Song; Ulrik B Nielsen; Jeffrey A Engelman; Kwok-Kin Wong
An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activation.
Cancer research 2010;70(6):2485-94.
2010: Anthony C Faber; Kwok-Kin Wong; Jeffrey A Engelman
Differences underlying EGFR and HER2 oncogene addiction.
Cell cycle (Georgetown, Tex.) 2010;9(5):851-2.
2010: Cristina M Contreras; Esra A Akbay; Teresa D Gallardo; J Marshall Haynie; Sreenath Sharma; Osamu Tagao; Nabeel Bardeesy; Masaya Takahashi; Jeff Settleman; Kwok-Kin Wong; Diego H Castrillon
Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy.
Disease models & mechanisms 2010;3(3-4):181-93.
2010: Kwok-Kin Wong; Jeffrey A Engelman; Lewis C Cantley
Targeting the PI3K signaling pathway in cancer.
Current opinion in genetics & development 2010;20(1):87-90.
2010: Aldo Roccaro; Antonio Sacco; Emanuel N Husu; Costas Pitsillides; Steven Vesole; Abdel Kareem Azab; Feda Azab; Molly Melhem; Hai T Ngo; Phong Quang; Patricia Maiso; Judith M Runnels; Mei-Chih Liang; Kwok-Kin Wong; Charles Lin; Irene M Ghobrial
Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia.
Blood 2010;115(3):559-69.
2010: Malgorzata Marcinkowska; Kwok-Kin Wong; David J Kwiatkowski; Piotr Kozlowski
Design and generation of MLPA probe sets for combined copy number and small-mutation analysis of human genes: EGFR as an example.
TheScientificWorldJournal 2010;10():2003-18.
2009: Wenjun Zhou; Dalia Ercan; Liang Chen; Cai-Hong Yun; Danan Li; Marzia Capelletti; Alexis B Cortot; Lucian R Chirieac; Roxana E Iacob; Robert F Padera; John R Engen; Kwok-Kin Wong; Michael J Eck; Nathanael S Gray; Pasi A Janne
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.
Nature 2009;462(7276):1070-4.
2009: Anthony C Faber; Danan Li; Youngchul Song; Mei-Chih Liang; Beow Y Yeap; Roderick T Bronson; Eugene Lifshits; Zhao Chen; Sauveur-Michel Maira; Carlos García-Echeverría; Kwok-Kin Wong; Jeffrey A Engelman
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(46):19503-8.
2009: Martin L Sos; Stefanie Fischer; Roland Ullrich; Martin Peifer; Johannes M Heuckmann; Mirjam Koker; Stefanie Heynck; Isabel Stückrath; Jonathan Weiss; Florian Fischer; Kathrin Michel; Aviva Goel; Lucia Regales; Katerina A Politi; Samanthi Perera; Matthäus Getlik; Lukas C Heukamp; Sascha Ansén; Thomas Zander; Rameen Beroukhim; Hamid Kashkar; Kevan M Shokat; William R Sellers; Daniel Rauh; Christine Orr; Klaus P Hoeflich; Lori Friedman; Kwok-Kin Wong; William Pao; Roman K Thomas
Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(43):18351-6.
2009: William Kim; Samanthi Perera; Bing Zhou; Julian Carretero; Jen Jen Yeh; Samuel A Heathcote; Autumn L Jackson; Petros Nikolinakos; Beatriz Ospina; George Naumov; Kathleyn A Brandstetter; Victor J Weigman; Sara Zaghlul; David Hayes; Robert F Padera; John V Heymach; Andrew L Kung; Norman E Sharpless; William G Kaelin; Kwok-Kin Wong
HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice.
The Journal of clinical investigation 2009;119(8):2160-70.
2009: Kenneth L. Scott; Omar Kabbarah; Mei-Chih Liang; Elena Ivanova; Valsamo Anagnostou; Joyce Wu; Sabin Dhakal; Min Wu; Shujuan Chen; Tamar Feinberg; Joseph Huang; Abdel Saci; Hans R Widlund; David E Fisher; Yonghong Xiao; David L Rimm; Alexei Protopopov; Kwok-Kin Wong; Lynda Chin
GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer.
Nature 2009;459(7250):1085-90.
2009: Ji Luo; Michael J Emanuele; Danan Li; Chad J Creighton; Michael R Schlabach; Thomas F Westbrook; Kwok-Kin Wong; Stephen J Elledge
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.
Cell 2009;137(5):835-48.
2009: Leena Gandhi; Kate McNamara; Danan Li; Christa L Borgman; Ultan McDermott; Kathleyn A Brandstetter; Robert F Padera; Lucian R Chirieac; Jeffrey E Settleman; Kwok-Kin Wong
Sunitinib prolongs survival in genetically engineered mouse models of multistep lung carcinogenesis.
Cancer prevention research (Philadelphia, Pa.) 2009;2(4):330-7.
2009: Marcus Schittenhelm; Christian Kollmannsberger; Karin Oechsle; Amy Harlow; Jason Morich; Friedemann Honecker; Raffael Kurek; Stephan Störkel; Lothar Kanz; Christopher L Corless; Kwok-Kin Wong; Carsten Bokemeyer; Michael C Heinrich
Molecular determinants of response to matuzumab in combination with paclitaxel for patients with advanced non-small cell lung cancer.
Molecular cancer therapeutics 2009;8(3):481-9.
2009: Samanthi A Perera; Danan Li; Takeshi Shimamura; Maria G Raso; Hongbin Ji; Liang Chen; Christa L Borgman; Sara Zaghlul; Kathleyn A Brandstetter; Shigeto Kubo; Masaya Takahashi; Lucian R Chirieac; Robert F Padera; Roderick T Bronson; Geoffrey I Shapiro; Heidi Greulich; Matthew Meyerson; Ulrich Guertler; Pilar Garin Chesa; Flavio Solca; Ignacio I Wistuba; Kwok-Kin Wong
HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(2):474-9.
2009: Shana N Wingo; Teresa D Gallardo; Esra A Akbay; Mei-Chi Liang; Cristina M Contreras; Todd Boren; Takeshi Shimamura; David S Miller; Norman E Sharpless; Nabeel Bardeesy; David J Kwiatkowski; John O Schorge; Kwok-Kin Wong; Diego H Castrillon
Somatic LKB1 mutations promote cervical cancer progression.
PloS one 2009;4(4):e5137.
2008: Jeffrey A Engelman; Liang Chen; Xiaohong Tan; Katherine Crosby; Alexander R Guimaraes; Rabi Upadhyay; Michel Maira; Kate McNamara; Samanthi A Perera; Youngchul Song; Lucian R Chirieac; Ramneet Kaur; Angela Lightbown; Jessica Simendinger; Timothy Li; Robert F Padera; Carlos García-Echeverría; Ralph Weissleder; Umar Mahmood; Lewis C Cantley; Kwok-Kin Wong
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.
Nature medicine 2008;14(12):1351-6.
2008: Geoffrey D Girnun; Liang Chen; Jessica Silvaggi; Ronny Drapkin; Lucian R Chirieac; Robert F Padera; Rabi Upadhyay; Scott B Vafai; Ralph Weissleder; Umar Mahmood; Elnaz Naseri; Stephanie Buckley; Danan Li; Jeremy Force; Kate McNamara; George Demetri; Bruce M Spiegelman; Kwok-Kin Wong
Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(20):6478-86.
2008: D Li; L Ambrogio; Takeshi Shimamura; S Kubo; M Takahashi; Lucian R Chirieac; Robert F Padera; Geoffrey I Shapiro; A Baum; F Himmelsbach; W J Rettig; Matthew Meyerson; F Solca; Heidi Greulich; Kwok-Kin Wong
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models.
Oncogene 2008;27(34):4702-11.
2008: Esra A Akbay; Cristina M Contreras; Samanthi A Perera; James P Sullivan; Russell R Broaddus; John O Schorge; Raheela Ashfaq; Hossein Saboorian; Kwok-Kin Wong; Diego H Castrillon
Differential roles of telomere attrition in type I and II endometrial carcinogenesis.
The American journal of pathology 2008;173(2):536-44.
2008: Jussi Koivunen; J Kim; J Lee; A M Rogers; J O Park; X Zhao; K Naoki; I Okamoto; K Nakagawa; B Y Yeap; Matthew Meyerson; Kwok-Kin Wong; W G Richards; D J Sugarbaker; Bruce E Johnson; Pasi A Janne
Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients.
British journal of cancer 2008;99(2):245-52.
2008: Takeshi Shimamura; Danan Li; Hongbin Ji; Henry J Haringsma; Elizabeth Liniker; Christa L Borgman; April M Lowell; Yuko Minami; Kate McNamara; Samanthi A Perera; Sara Zaghlul; Roman K Thomas; Heidi Greulich; Susumu Kobayashi; Lucian R Chirieac; Robert F Padera; Shigeto Kubo; Masaya Takahashi; Daniel G Tenen; Matthew Meyerson; Kwok-Kin Wong; Geoffrey I Shapiro
Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance.
Cancer research 2008;68(14):5827-38.
2008: Amit Dutt; Helga B Salvesen; Tzu-Hsiu Chen; Alex H Ramos; Robert C Onofrio; Charlie Hatton; Richard Nicoletti; Wendy Winckler; Rupinder Grewal; Megan Hanna; Nicolas Wyhs; Liuda Ziaugra; Daniel J Richter; Jone Trovik; Ingeborg B Engelsen; Ingunn M Stefansson; Tim Fennell; Kristian Cibulskis; Michael C Zody; Lars A Akslen; Stacey Gabriel; Kwok-Kin Wong; William R Sellers; Matthew Meyerson; Heidi Greulich
Drug-sensitive FGFR2 mutations in endometrial carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(25):8713-7.
2008: Xiangzhi Zhou; Haihua Bao; Ruqayyah Al-Hashem; Hongbin Ji; Mitchell S Albert; Kwok-Kin Wong; Yanping Sun
Magnetic resonance imaging of the response of a mouse model of non-small cell lung cancer to tyrosine kinase inhibitor treatment.
Comparative medicine 2008;58(3):276-81.
2008: Kwok-Kin Wong
Searching for a magic bullet in NSCLC: the role of epidermal growth factor receptor mutations and tyrosine kinase inhibitors.
Lung cancer (Amsterdam, Netherlands) 2008;60 Suppl 2():S10-8.
2008: Samanthi A Perera; richard s maser; Huili Xia; Kate McNamara; Alexei Protopopov; Liang Chen; Aram F Hezel; Carla F. Kim; Roderick T Bronson; Diego H Castrillon; Lynda Chin; Nabeel Bardeesy; Ronald A DePinho; Kwok-Kin Wong
Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer.
Carcinogenesis 2008;29(4):747-53.
2008: Naomi M Simon; Kate McNamara; C W Chow; richard s maser; George I Papakostas; Mark H Pollack; Andrew A Nierenberg; Maurizio Fava; Kwok-Kin Wong
A detailed examination of cytokine abnormalities in Major Depressive Disorder.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2008;18(3):230-3.
2008: Cai-Hong Yun; Kristen E Mengwasser; Angela V Toms; Michele S Woo; Heidi Greulich; Kwok-Kin Wong; Matthew Meyerson; Michael J Eck
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):2070-5.
2008: Cristina M Contreras; Sushma Gurumurthy; J Marshall Haynie; Lane Shirley; Esra A Akbay; Shana N Wingo; John O Schorge; Russell R Broaddus; Kwok-Kin Wong; Nabeel Bardeesy; Diego H Castrillon
Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.
Cancer research 2008;68(3):759-66.
2007: Jennifer O'Neil; Joëlle Tchinda; Alejandro Gutierrez; Lisa A Moreau; richard s maser; Kwok-Kin Wong; Wei Li; Keith McKenna; Xiaole (Shirley) Liu; Bin Feng; Donna Neuberg; Lewis B Silverman; Daniel J DeAngelo; Jeffery L Kutok; Rodney Rothstein; Ronald A DePinho; Lynda Chin; Charles Lee; A Thomas Look
Alu elements mediate MYB gene tandem duplication in human T-ALL.
The Journal of experimental medicine 2007;204(13):3059-66.
2007: Jeffrey A Engelman; Kreshnik Zejnullahu; Christopher-Michael Gale; Eugene Lifshits; Andrea J Gonzales; Takeshi Shimamura; Feng Zhao; Patrick W Vincent; George N Naumov; James E Bradner; Irene W Althaus; Leena Gandhi; Geoffrey I Shapiro; James M Nelson; John V Heymach; Matthew Meyerson; Kwok-Kin Wong; Pasi A Janne
PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib.
Cancer research 2007;67(24):11924-32.
2007: Jing Deng; Takeshi Shimamura; Samanthi Perera; Nicole E Carlson; Dongpo Cai; Geoffrey I Shapiro; Kwok-Kin Wong; Anthony Letai
Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion.
Cancer research 2007;67(24):11867-75.
2007: Hongbin Ji; Matthew Robert Ramsey; David Hayes; Cheng Fan; Kate McNamara; Piotr Kozlowski; Chad Torrice; Michael Wu; Takeshi Shimamura; Samanthi A Perera; Mei-Chih Liang; Dongpo Cai; George N Naumov; Lei Bao; Cristina M Contreras; Danan Li; Liang Chen; Janakiraman Krishnamurthy; Jussi Koivunen; Lucian R Chirieac; Robert F Padera; Roderick T Bronson; Neal I Lindeman; David C Christiani; Xihong Lin; Geoffrey I Shapiro; Pasi A Janne; Bruce E Johnson; Matthew Meyerson; David J Kwiatkowski; Diego H Castrillon; Nabeel Bardeesy; Norman E Sharpless; Kwok-Kin Wong
LKB1 modulates lung cancer differentiation and metastasis.
Nature 2007;448(7155):807-10.
2007: Kwok-Kin Wong
HKI-272 in non small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(15 Pt 2):s4593-6.
2007: Thomas J Lynch; Philip D Bonomi; Charles Butts; Angela M Davies; Jeffrey A Engelman; Ramaswamy Govindan; Roy S Herbst; John V Heymach; Bruce E Johnson; Renato G Martins; Roman Perez-Soler; Gregory J Riely; Alan B Sandler; Lecia V Sequist; Mark A Socinski; Kwok-Kin Wong; Carol S Hart
Novel agents in the treatment of lung cancer: Fourth Cambridge Conference.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(15 Pt 2):s4583-8.
2007: Y Minami; Takeshi Shimamura; Keerti V Shah; Thomas LaFramboise; Karen A Glatt; E Liniker; C L Borgman; H J Haringsma; Whei Feng; Barbara A Weir; April M Lowell; Jeffrey C Lee; J Wolf; Geoffrey I Shapiro; Kwok-Kin Wong; Matthew Meyerson; Roman K Thomas
The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272.
Oncogene 2007;26(34):5023-7.
2007: Helicia Paz; Christie A Wong; Wei Li; Leah Santat; Kwok-Kin Wong; Saswati Chatterjee
Quiescent subpopulations of human CD34-positive hematopoietic stem cells are preferred targets for stable recombinant adeno-associated virus type 2 transduction.
Human gene therapy 2007;18(7):614-26.
2007: Danan Li; Takeshi Shimamura; Hongbin Ji; Liang Chen; Henry J Haringsma; Kate McNamara; Mei-Chih Liang; Samanthi A Perera; Sara Zaghlul; Christa L Borgman; Shigeto Kubo; Masaya Takahashi; Yanping Sun; Lucian R Chirieac; Robert F Padera; Neal Lindeman; Pasi A Janne; Roman K Thomas; Matthew Meyerson; Michael J Eck; Jeffrey A Engelman; Geoffrey I Shapiro; Kwok-Kin Wong
Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy.
Cancer cell 2007;12(1):81-93.
2007: richard s maser; Bhudipa Choudhury; Peter J Campbell; Bin Feng; Kwok-Kin Wong; Alexei Protopopov; Jennifer O'Neil; Alejandro Gutierrez; Elena Ivanova; Ilana Perna; Eric Lin; Vidya Mani; Shan Jiang; Kate McNamara; Sara Zaghlul; Sarah Edkins; Claire Stevens; Cameron Brennan; Eric S Martin; Ruprecht Wiedemeyer; Omar Kabbarah; Cristina Nogueira; Gavin Histen; Jon Aster; Marc Mansour; Veronique Duke; Letizia Foroni; Adele K Fielding; Anthony H Goldstone; Jacob M Rowe; Yaoqi A Wang; A Thomas Look; Michael R Stratton; Lynda Chin; P Andrew Futreal; Ronald A DePinho
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.
Nature 2007;447(7147):966-71.
2007: Hongbin Ji; Zhenxiong Wang; Samanthi A Perera; Danan Li; Mei-Chih Liang; Sara Zaghlul; Kate McNamara; Liang Chen; Mitchell S Albert; Yanping Sun; Ruqayyah Al-Hashem; Lucian R Chirieac; Robert F Padera; Roderick T Bronson; Roman K Thomas; Levi A Garraway; Pasi A Janne; Bruce E Johnson; Lynda Chin; Kwok-Kin Wong
Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models.
Cancer research 2007;67(10):4933-9.
2007: Kwok-Kin Wong; richard s maser; E Sahin; S T Bailey; Huili Xia; Hongbin Ji; Kate McNamara; M Naylor; Roderick T Bronson; S Ghosh; R Welsh; Ronald A DePinho
Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres.
Oncogene 2007;26(20):2815-21.
2007: Yuki Yuza; Karen A Glatt; Jingrui Jiang; Heidi Greulich; Yuko Minami; Michele S Woo; Takeshi Shimamura; Geoffrey I Shapiro; Jeffrey C Lee; Hongbin Ji; Whei Feng; Tzu-Hsiu Chen; Haruhiko Yanagisawa; Kwok-Kin Wong; Matthew Meyerson
Allele-dependent variation in the relative cellular potency of distinct EGFR inhibitors.
Cancer biology & therapy 2007;6(5):661-7.
2007: Roman K Thomas; Alissa C Baker; Ralph M Debiasi; Wendy Winckler; Thomas Laframboise; William M Lin; Meng Wang; Whei Feng; Thomas Zander; Laura MacConaill; Laura E Macconnaill; Jeffrey C Lee; Rick Nicoletti; Charlie Hatton; Mary Goyette; Luc Girard; Kuntal Majmudar; Liuda Ziaugra; Kwok-Kin Wong; Stacey Gabriel; Rameen Beroukhim; Michael Peyton; Jordi Barretina; Amit Dutt; Caroline Emery; Heidi Greulich; Kinjal Shah; Hidefumi Sasaki; Adi Gazdar; John Minna; Scott A Armstrong; Ingo K Mellinghoff; F Stephen Hodi; Glenn Dranoff; Paul Mischel; Tim F Cloughesy; Stan F Nelson; Linda M Liau; Kirsten Mertz; Mark A Rubin; Holger Moch; Massimo Loda; William Catalona; Jonathan Fletcher; Sabina Signoretti; Frederic Kaye; Kenneth C Anderson; George D Demetri; Reinhard Dummer; Stephan Wagner; Meenhard Herlyn; William R Sellers; Matthew Meyerson; Levi A Garraway
High-throughput oncogene mutation profiling in human cancer.
Nature genetics 2007;39(3):347-51.
2007: richard s maser; Kwok-Kin Wong; Erguen Sahin; Huili Xia; Maria Naylor; H Mason Hedberg; Steven E Artandi; Ronald A DePinho
DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.
Molecular and cellular biology 2007;27(6):2253-65.
2007: Danan Li; Hongbin Ji; Sara Zaghlul; Kate McNamara; Mei-Chih Liang; Takeshi Shimamura; Shigeto Kubo; Masaya Takahashi; Lucian R Chirieac; Robert F Padera; Andrew M Scott; Achim A Jungbluth; Webster K Cavenee; Lloyd J Old; George D Demetri; Kwok-Kin Wong
Therapeutic anti-EGFR antibody 806 generates responses in murine de novo EGFR mutant-dependent lung carcinomas.
The Journal of clinical investigation 2007;117(2):346-52.
2006: David C Christiani; William Pao; James DeMartini; R Ilona Linnoila; Alvin M Malkinson; Amir Onn; Katerina Politi; Michael Sharp; Kwok-Kin Wong; Kwok Kim
BAC consensus conference, November 4-6, 2004: epidemiology, pathogenesis, and preclinical models.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006;1(9 Suppl):S2-7.
2006: Yeun-Jin Ju; Jeong Eun Park; Kyoung Mi Juhn; Jaemin Jeong; Miyong Yun; Myung-Jin Park; Gil-Hong Park; Kang-Yell Choi; Myung-Haing Cho; Kwok-Kin Wong; Won-Bong Park; Kee-Ho Lee
Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: effect of p53.
International journal of oncology 2006;29(4):753-63.
2006: Hongbin Ji; Norman E Sharpless; Kwok-Kin Wong
EGFR targeted therapy: view from biological standpoint.
Cell cycle (Georgetown, Tex.) 2006;5(18):2072-6.
2006: Naomi M Simon; Jordan W Smoller; Kate McNamara; richard s maser; Alyson K Zalta; Mark H Pollack; Andrew A Nierenberg; Maurizio Fava; Kwok-Kin Wong
Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging.
Biological psychiatry 2006;60(5):432-5.
2006: Amit Dutt; Kwok-Kin Wong
Mouse models of lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 2):4396s-4402s.
2006: Thomas J Lynch; Alex A. Adjei; Paul A Bunn; Tim G Eisen; Jeffrey A Engelman; Glenwood Goss; Daniel A Haber; John V Heymach; Pasi A Janne; Bruce E Johnson; David H Johnson; Rogerio Lilenbaum; Matthew Meyerson; Alan B Sandler; Lecia V Sequist; Jeffrey Settleman; Kwok-Kin Wong; Carol S Hart
Summary statement: novel agents in the treatment of lung cancer: advances in epidermal growth factor receptor-targeted agents.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 2):4365s-4371s.
2006: Takeshi Shimamura; Hongbin Ji; Yuko Minami; Roman K Thomas; April M Lowell; Kinjal Shah; Heidi Greulich; Karen A Glatt; Matthew Meyerson; Geoffrey I Shapiro; Kwok-Kin Wong
Non-small-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272.
Cancer research 2006;66(13):6487-91.
2006: Roman K Thomas; Elizabeth Nickerson; Jan F Simons; Pasi A Janne; Torstein Tengs; Yuki Yuza; Levi A Garraway; Thomas LaFramboise; Jeffrey C Lee; Kinjal Shah; Keith O'Neill; Hidefumi Sasaki; Neal Lindeman; Kwok-Kin Wong; Ana M Borras; Edward J Gutmann; Konstantin H Dragnev; Ralph DeBiasi; Tzu-Hsiu Chen; Karen A Glatt; Heidi Greulich; Brian Desany; Christine K Lubeski; William Brockman; Pablo Alvarez; Stephen K Hutchison; John Leamon; Michael T Ronan; Gregory S Turenchalk; Michael Egholm; William R Sellers; Jonathan M Rothberg; Matthew Meyerson
Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing.
Nature medicine 2006;12(7):852-5.
2006: Hongbin Ji; Danan Li; Liang Chen; Takeshi Shimamura; Susumu Kobayashi; Kate McNamara; Umar Mahmood; Albert Mitchell; Yangping Sun; Ruqayyah Al-Hashem; Lucian R Chirieac; Robert F Padera; Roderick T Bronson; William Kim; Pasi A Janne; Geoffrey I Shapiro; Daniel Tenen; Bruce E Johnson; Ralph Weissleder; Norman E Sharpless; Kwok-Kin Wong
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.
Cancer cell 2006;9(6):485-95.
2006: Hongbin Ji; Xiaojun Zhao; Yuki Yuza; Takeshi Shimamura; Danan Li; Alexei Protopopov; Boonim L Jung; Kate McNamara; Huili Xia; Karen A Glatt; Roman K Thomas; Hidefumi Sasaki; James W Horner; Michael J Eck; Albert Mitchell; Yangping Sun; Ruqayyah Al-Hashem; Roderick T Bronson; Sridhar K Rabindran; Carolyn Discafani; Elizabeth Maher; Geoffrey I Shapiro; Matthew Meyerson; Kwok-Kin Wong
Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(20):7817-22.
2006: Hongbin Ji; A McGarry Houghton; T J Mariani; S Perera; Carla F. Kim; Robert F Padera; Giovanni Tonon; Kate McNamara; L A Marconcini; Aram F Hezel; N El-Bardeesy; Roderick T Bronson; D Sugarbaker; richard s maser; Steven D Shapiro; Kwok-Kin Wong
K-ras activation generates an inflammatory response in lung tumors.
Oncogene 2006;25(14):2105-12.
2006: Daniela S Bassères; Elena Levantini; Hongbin Ji; Stefano Monti; Shannon Elf; Tajhal Dayaram; Maris L Fenyus; Olivier Kocher; Todd R Golub; Kwok-Kin Wong; Balazs Halmos; Daniel G Tenen
Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice.
Molecular and cellular biology 2006;26(3):1109-23.
2005: Susumu Kobayashi; Hongbin Ji; Yuki Yuza; Matthew Meyerson; Kwok-Kin Wong; Daniel G Tenen; Balazs Halmos
An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor.
Cancer research 2005;65(16):7096-101.
2005: Leah Santat; Helicia Paz; Christie Wong; Lijing Li; James Macer; Stephen Forman; Kwok-Kin Wong; Saswati Chatterjee
Recombinant AAV2 transduction of primitive human hematopoietic stem cells capable of serial engraftment in immune-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):11053-8.
2005: Giovanni Tonon; Kwok-Kin Wong; Gautam Maulik; Cameron Brennan; Bin Feng; Yunyu Zhang; Deepak Khatry; Alexei Protopopov; Mingjian James You; Andrew J Aguirre; Eric S Martin; Zhaohui Yang; Hongbin Ji; Lynda Chin; Ronald A DePinho
High-resolution genomic profiles of human lung cancer.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(27):9625-30.
2005: Kwok-Kin Wong; Saswati Chatterjee
Vaccine development for chronic myelogenous leukaemia.
Lancet 2005;365(9460):631-2.
2005: Kwok-Kin Wong; E Wu; M Ng; Y Wu; H Tse; C Lau; G Lo; E Yang
Image registration in myocardial perfusion MRI.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2005;1():453-4.
2005: Giovanni Tonon; Cameron Brennan; Alexei Protopopov; Gautam Maulik; Bin Feng; Yunyu Zhang; Deepak Khatry; Mingjian James You; Andrew J Aguirre; Eric S Martin; Z Yang; Hongbin Ji; Lynda Chin; Kwok-Kin Wong; Ronald A DePinho
Common and contrasting genomic profiles among the major human lung cancer subtypes.
Cold Spring Harbor symposia on quantitative biology 2005;70():11-24.
2003: Ji-Yao Sun; David Senitzer; Stephen J Forman; Saswati Chatterjee; Kwok-Kin Wong
Identification of new MHC-restriction elements for presentation of the p210(BCR-ABL) fusion region to human cytotoxic T lymphocytes.
Cancer immunology, immunotherapy : CII 2003;52(12):761-70.
2003: Kwok-Kin Wong; Ronald A DePinho
Walking the telomere plank into cancer.
Journal of the National Cancer Institute 2003;95(16):1184-6.
2003: Ji-Yao Sun; V Anand-Jawa; Saswati Chatterjee; Kwok-Kin Wong
Immune responses to adeno-associated virus and its recombinant vectors.
Gene therapy 2003;10(11):964-76.
2003: Ronald A DePinho; Kwok-Kin Wong
The age of cancer: telomeres, checkpoints, and longevity.
The Journal of clinical investigation 2003;111(7):S9-14.
2003: Kwok-Kin Wong; richard s maser; Robert M Bachoo; Jayant Menon; Daniel R Carrasco; Yansong Gu; Frederick W Alt; Ronald A DePinho
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.
Nature 2003;421(6923):643-8.
2002: Ji-Yao Sun; Robert S Krouse; Stephen J Forman; David Senitzer; Irena Sniecinski; Saswati Chatterjee; Kwok-Kin Wong
Immunogenicity of a p210(BCR-ABL) fusion domain candidate DNA vaccine targeted to dendritic cells by a recombinant adeno-associated virus vector in vitro.
Cancer research 2002;62(11):3175-83.
2000: Kwok-Kin Wong; S Chang; Sarah R Weiler; S Ganesan; Jayanta Chaudhuri; C Zhu; Steven E Artandi; K Lenhard Rudolph; GJ Gottlieb; Lynda Chin; Frederick W Alt; Ronald A DePinho
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation.
Nature genetics 2000;26(1):85-8.
2000: Auayporn Nademanee; Arturo Molina; Andrew Dagis; David S Snyder; Margaret R O'Donnell; Pablo Parker; Anthony Stein; Eileen Smith; I Planas; Ashwin Kashyap; Ricardo Spielberger; Henry Fung; Amrita Krishnan; Ravi Bhatia; Kwok-Kin Wong; George Somlo; Kim Margolin; Warren Chow; Irena Sniecinski; Nayana L Vora; Marilyn L Slovak; Joyce C Niland; Stephen J Forman
Autologous stem-cell transplantation for poor-risk and relapsed intermediate- and high-grade non-Hodgkin's lymphoma.
Clinical lymphoma 2000;1(1):46-54.
2000: Nabeel Bardeesy; Kwok-Kin Wong; Ronald A DePinho; Lynda Chin
Animal models of melanoma: recent advances and future prospects.
Advances in cancer research 2000;79():123-56.
1999: Saswati Chatterjee; W Li; C A Wong; G Fisher-Adams; D Lu; Mausumee Guha; J A Macer; Stephen J Forman; Kwok-Kin Wong
Transduction of primitive human marrow and cord blood-derived hematopoietic progenitor cells with adeno-associated virus vectors.
Blood 1999;93(6):1882-94.
1997: Auayporn Nademanee; Arturo Molina; Margaret R O'Donnell; Andrew Dagis; David S Snyder; Pablo Parker; Anthony Stein; Eileen Smith; I Planás; Ashwin Kashyap; Ricardo Spielberger; Henry Fung; Kwok-Kin Wong; George Somlo; Kim Margolin; Warren Chow; Irena Sniecinski; Nayana L Vora; Karl G Blume; Joyce C Niland; Stephen J Forman
Results of high-dose therapy and autologous bone marrow/stem cell transplantation during remission in poor-risk intermediate- and high-grade lymphoma: international index high and high-intermediate risk group.
Blood 1997;90(10):3844-52.
1996: G Fisher-Adams; Kwok-Kin Wong; G Podsakoff; Stephen J Forman; Saswati Chatterjee
Integration of adeno-associated virus vectors in CD34+ human hematopoietic progenitor cells after transduction.
Blood 1996;88(2):492-504.
1996: Kwok-Kin Wong; Saswati Chatterjee
Adeno-associated virus based vectors as antivirals.
Current topics in microbiology and immunology 1996;218():145-70.
1996: Saswati Chatterjee; Kwok-Kin Wong
Adeno-associated virus vectors for gene therapy of the hematopoietic system.
Current topics in microbiology and immunology 1996;218():61-73.
1995: Saswati Chatterjee; D Lu; G Podsakoff; Kwok-Kin Wong
Strategies for efficient gene transfer into hematopoietic cells. The use of adeno-associated virus vectors in gene therapy.
Annals of the New York Academy of Sciences 1995;770():79-90.
1994: D Lu; Saswati Chatterjee; D Brar; Kwok-Kin Wong
Ribozyme-mediated in vitro cleavage of transcripts arising from the major transforming genes of human papillomavirus type 16.
Cancer gene therapy 1994;1(4):267-77.
1994: G Podsakoff; Kwok-Kin Wong; Saswati Chatterjee
Efficient gene transfer into nondividing cells by adeno-associated virus-based vectors.
Journal of virology 1994;68(9):5656-66.
1992: John A Zaia; Saswati Chatterjee; Kwok-Kin Wong; D Elkins; N R Taylor; John J Rossi
Status of ribozyme and antisense-based developmental approaches for anti-HIV-1 therapy.
Annals of the New York Academy of Sciences 1992;660():95-106.
1992: Kwok-Kin Wong; Saswati Chatterjee
Controlling herpes simplex virus infections: is intracellular immunization the way of the future?
Current topics in microbiology and immunology 1992;179():159-74.