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Kwong-Kwok Wong

Research Profile

Disorders

Procedures

Physiology

Chemicals & Drugs

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Oligonucleotide Array Sequence Analysis

Anatomy

Tumor Cell Line

Genes & Molecular Sequences

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Publications

TOP 3
Gong Yang; David M Gershenson; Imelda Mercado-Uribe; Asha S Multani; Subrata Sen; Ie-Ming Shih; Kwong-Kwok Wong; Jinsong Liu
RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis.
Tarrik M Zaid; Michael J Birrer; Ngai-Na Co; Tom Harding; Suet-Ying Kwan; Cecilia S Leung; Gabriel Lopez-Berestein; Cristian Rodriguez-Aguay; Rosie S Schmandt; Anil K Sood; Melissa S Thompson; Kwong-Kwok Wong; Tsz-Lun Yeung; Samuel C Mok
Identification of FGFR4 as a potential therapeutic target for advanced-stage, high-grade serous ovarian cancer.
Huijuan Song; Yvonne T Tsang; Celestine S Tung; David M Gershenson; Daisy I Izaguirre; Erin R King; Suet-Yan Kwan; Samuel C Mok; Zhifei Zu; Kwong-Kwok Wong
PAX2 Expression in Ovarian Cancer.

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All Publications

2013: Gong Yang; David M Gershenson; Imelda Mercado-Uribe; Asha S Multani; Subrata Sen; Ie-Ming Shih; Kwong-Kwok Wong; Jinsong Liu
RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis.
International journal of cancer. Journal international du cancer 2013;133(2):275-85.
2013: Tarrik M Zaid; Michael J Birrer; Ngai-Na Co; Tom Harding; Suet-Ying Kwan; Cecilia S Leung; Gabriel Lopez-Berestein; Cristian Rodriguez-Aguay; Rosie S Schmandt; Anil K Sood; Melissa S Thompson; Kwong-Kwok Wong; Tsz-Lun Yeung; Samuel C Mok
Identification of FGFR4 as a potential therapeutic target for advanced-stage, high-grade serous ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(4):809-20.
2013: Huijuan Song; Yvonne T Tsang; Celestine S Tung; David M Gershenson; Daisy I Izaguirre; Erin R King; Suet-Yan Kwan; Samuel C Mok; Zhifei Zu; Kwong-Kwok Wong
PAX2 Expression in Ovarian Cancer.
International journal of molecular sciences 2013;14(3):6090-105.
2012: Lisa K Mullany; Erin R King; Zhilin Liu; Kwong-Kwok Wong; JoAnne S Richards
Wild-type tumor repressor protein 53 (Trp53) promotes ovarian cancer cell survival.
Endocrinology 2012;153(4):1638-48.
2011: Erin R King; Anais Malpica; Samuel C Mok; Yvonne T M Tsang; Michael T Deavers; David M Gershenson; Zhifei Zu; Kwong-Kwok Wong
The insulin-like growth factor 1 pathway is a potential therapeutic target for low-grade serous ovarian carcinoma.
Gynecologic oncology 2011;123(1):13-8.
2011: L K Mullany; L D White; Kwong-Kwok Wong; L Xin; M L Anderson; C J Creighton; M Deavers; H-Y Fan; P Gunaratne; Zijuan Liu; A Marshall; J S Richards
Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo.
Oncogene 2011;30(32):3522-36.
2011: Erin R King; Celestine S Tung; Yvonne T M Tsang; Zhifei Zu; Gabriel T M Lok; Michael T Deavers; Anais Malpica; Judith K Wolf; Karen H Lu; Michael J Birrer; Samuel C Mok; David M Gershenson; Kwong-Kwok Wong
The anterior gradient homolog 3 (AGR3) gene is associated with differentiation and survival in ovarian cancer.
The American journal of surgical pathology 2011;35(6):904-12.
2010: Kwong-Kwok Wong; Yvonne T M Tsang; Michael T Deavers; Samuel C Mok; Zhifei Zu; Charlotte Sun; Anais Malpica; Judith K Wolf; Karen H Lu; David M Gershenson
BRAF mutation is rare in advanced-stage low-grade ovarian serous carcinomas.
The American journal of pathology 2010;177(4):1611-7.
2010: Takashi Mine; Satoko Matsueda; Hui Gao; Yufeng Li; Kwong-Kwok Wong; George E Peoples; Soldano Ferrone; Constantin G Ioannides
Created Gli-1 duplex short-RNA (i-Gli-RNA) eliminates CD44 Hi progenitors of taxol-resistant ovarian cancer cells.
Oncology reports 2010;23(6):1537-43.
2010: Lei Xu; M B Nilsson; P Saintigny; T Cascone; Matthew H Herynk; Z Du; P G Nikolinakos; Ying Yang; Ludmila Prudkin; Diane Liu; J Jack Lee; Faye M Johnson; Kwong-Kwok Wong; L Girard; Adi F Gazdar; John D Minna; Jonathan M Kurie; Ignacio I Wistuba; John V Heymach
Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1alpha in non-small cell lung cancer cells.
Oncogene 2010;29(18):2616-27.
2009: Samuel C Mok; Tomas Bonome; Vinod Vathipadiekal; Aaron Bell; Michael E Johnson; Kwong-Kwok Wong; Dong-Choon Park; Ke Hao; Daniel K P Yip; Howard Donninger; Laurent Ozbun; Goli Samimi; John Brady; Mike Randonovich; Cynthia A Pise-Masison; J Carl Barrett; Wing H Wong; William R Welch; Ross S Berkowitz; Michael J Birrer
A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotein 2.
Cancer cell 2009;16(6):521-32.
2009: Celestine S Tung; Samuel C Mok; Yvonne T M Tsang; Zhifei Zu; Huijuan Song; Jinsong Liu; Michael T Deavers; Anais Malpica; Judith K Wolf; Karen H Lu; David M Gershenson; Kwong-Kwok Wong
PAX2 expression in low malignant potential ovarian tumors and low-grade ovarian serous carcinomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009;22(9):1243-50.
2009: Takashi Mine; Satoko Matsueda; Yufeng Li; Hiroshi Tokumitsu; Hui Gao; Cristopher Danes; Kwong-Kwok Wong; Xinhui Wang; Soldano Ferrone; Constantin G Ioannides
Breast cancer cells expressing stem cell markers CD44+ CD24 lo are eliminated by Numb-1 peptide-activated T cells.
Cancer immunology, immunotherapy : CII 2009;58(8):1185-94.
2009: Joseph Kwong; Franky Leung Chan; Kwong-Kwok Wong; Michael J Birrer; Kyra M Archibald; Frances R Balkwill; Ross S Berkowitz; Samuel C Mok
Inflammatory cytokine tumor necrosis factor alpha confers precancerous phenotype in an organoid model of normal human ovarian surface epithelial cells.
Neoplasia (New York, N.Y.) 2009;11(6):529-41.
2009: Kwong-Kwok Wong
Recent developments in anti-cancer agents targeting the Ras/Raf/ MEK/ERK pathway.
Recent patents on anti-cancer drug discovery 2009;4(1):28-35.
2009: Kwong-Kwok Wong
Oral-specific chemical carcinogenesis in mice: an exciting model for cancer prevention and therapy.
Cancer prevention research (Philadelphia, Pa.) 2009;2(1):10-3.
2008: Dong Choon Park; Seung Geun Yeo; Mark R Wilson; Justin J Yerbury; Joseph Kwong; William R Welch; Yang-Kyu Choi; Michael J Birrer; Samuel C Mok; Kwong-Kwok Wong
Clusterin interacts with Paclitaxel and confer Paclitaxel resistance in ovarian cancer.
Neoplasia (New York, N.Y.) 2008;10(9):964-72.
2008: Qin Shu; Kwong-Kwok Wong; Jack Meng Fen Su; Adekunle M Adesina; Li Tian Yu; Yvonne T M Tsang; Barbara C Antalffy; Patricia Baxter; Laszlo Perlaky; Jianhua Yang; Robert C Dauser; Murali Chintagumpala; Susan M Blaney; Ching C Lau; Xiao-Nan Li
Direct orthotopic transplantation of fresh surgical specimen preserves CD133+ tumor cells in clinically relevant mouse models of medulloblastoma and glioma.
Stem cells (Dayton, Ohio) 2008;26(6):1414-24.
2008: Hidehiro Takei; Subashini T Yogeswaren; Kwong-Kwok Wong; Vidya Mehta; Murali Chintagumpala; Robert Dauser; Ching C Lau; Adekunle M Adesina
Expression of oligodendroglial differentiation markers in pilocytic astrocytomas identifies two clinical subsets and shows a significant correlation with proliferation index and progression free survival.
Journal of neuro-oncology 2008;86(2):183-90.
2007: Kwong-Kwok Wong; Karen H Lu; Anais Malpica; Diane C Bodurka; Hyun S Shvartsman; Rosemarie Schmandt; Angela D Thornton; Michael T Deavers; Elvio G Silva; David M Gershenson
Significantly greater expression of ER, PR, and ECAD in advanced-stage low-grade ovarian serous carcinoma as revealed by immunohistochemical analysis.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2007;26(4):404-9.
2007: Michael J Birrer; Michael E Johnson; Ke Hao; Kwong-Kwok Wong; Dong-Choon Park; Aaron Bell; William R Welch; Ross S Berkowitz; Samuel C Mok
Whole genome oligonucleotide-based array comparative genomic hybridization analysis identified fibroblast growth factor 1 as a prognostic marker for advanced-stage serous ovarian adenocarcinomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(16):2281-7.
2007: Xiao-Nan Li; Qin Shu; Jack Meng Fen Su; Adekunle M Adesina; Kwong-Kwok Wong; Laszlo Perlaky; Barbara Antalffy; Susan M Blaney; Ching C Lau
Differential expression of survivin splice isoforms in medulloblastomas.
Neuropathology and applied neurobiology 2007;33(1):67-76.
2007: Kwong-Kwok Wong; David M Gershenson
The continuum of serous tumors of low malignant potential and low-grade serous carcinomas of the ovary.
Disease markers 2007;23(5-6):377-87.
2007: Samuel C Mok; Joseph Kwong; William R Welch; Goli Samimi; Laurent L Ozbun; Tomas Bonome; Michael J Birrer; Ross S Berkowitz; Kwong-Kwok Wong
Etiology and pathogenesis of epithelial ovarian cancer.
Disease markers 2007;23(5-6):367-76.
2007: Samuel C Mok; Kevin M Elias; Kwong-Kwok Wong; Kae Ho; Tomas Bonome; Michael J Birrer
Biomarker discovery in epithelial ovarian cancer by genomic approaches.
Advances in cancer research 2007;96():1-22.
2006: Kwong-Kwok Wong; Yvonne T M Tsang; Yi-Mieng Chang; Jack Meng Fen Su; Angela M Di Francesco; Daniela Meco; Riccardo Riccardi; Laszlo Perlaky; Robert Dauser; Adekunle M Adesina; Meenakshi B Bhattacharjee; Murali Chintagumpala; Ching C Lau
Genome-wide allelic imbalance analysis of pediatric gliomas by single nucleotide polymorphic allele array.
Cancer research 2006;66(23):11172-8.
2006: Yufeng Li; Kwong-Kwok Wong; Satoko Matsueda; Clay L Efferson; David Z Chang; Constantin G Ioannides; Naotake Tsuda
Mitogen stimulation activates different signaling pathways in early- and late-divided T cells as revealed by cDNA microarray analysis.
International journal of molecular medicine 2006;18(6):1127-39.
2006: Joseph Kwong; Ji-Young Lee; Kwong-Kwok Wong; Xiaofeng Zhou; David T W Wong; Kwok-Wai Lo; William R Welch; Ross S Berkowitz; Samuel C Mok
Candidate tumor-suppressor gene DLEC1 is frequently downregulated by promoter hypermethylation and histone hypoacetylation in human epithelial ovarian cancer.
Neoplasia (New York, N.Y.) 2006;8(4):268-78.
2005: Colleen M Feltmate; Kenneth R Lee; Michael Johnson; John O Schorge; Kwong-Kwok Wong; Ke Hao; William R Welch; Debra A Bell; Ross S Berkowitz; Samuel C Mok
Whole-genome allelotyping identified distinct loss-of-heterozygosity patterns in mucinous ovarian and appendiceal carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(21):7651-7.
2005: Hiroshi Tsuda; Yoichi M Ito; Yasuo Ohashi; Kwong-Kwok Wong; Yasunori Hashiguchi; William R Welch; Ross S Berkowitz; Michael J Birrer; Samuel C Mok
Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(19 Pt 1):6880-8.
2005: Tsz-Kwong Man; Murali Chintagumpala; Jaya Visvanathan; Jianhe Shen; Laszlo Perlaky; John Hicks; Mark Johnson; Nelson A Davino; Jeffrey Murray; Lee Helman; William Meyer; Timothy Triche; Kwong-Kwok Wong; Ching C Lau
Expression profiles of osteosarcoma that can predict response to chemotherapy.
Cancer research 2005;65(18):8142-50.
2005: Kwong-Kwok Wong; Yi-Mieng Chang; Yvonne T M Tsang; Laszlo Perlaky; Jack Meng Fen Su; Adekunle M Adesina; Dawna L Armstrong; Meenakshi B Bhattacharjee; Robert Dauser; Susan M Blaney; Murali Chintagumpala; Ching C Lau
Expression analysis of juvenile pilocytic astrocytomas by oligonucleotide microarray reveals two potential subgroups.
Cancer research 2005;65(1):76-84.
2005: Heather G Huddleston; Kwong-Kwok Wong; William R Welch; Ross S Berkowitz; Samuel C Mok
Clinical applications of microarray technology: creatine kinase B is an up-regulated gene in epithelial ovarian cancer and shows promise as a serum marker.
Gynecologic oncology 2005;96(1):77-83.
2004: Hiroshi Tsuda; Michael J Birrer; Yoichi M Ito; Yasuo Ohashi; Ming Lin; Cheng Lee; Wing H Wong; Pulivarthi H Rao; Ching C Lau; Ross S Berkowitz; Kwong-Kwok Wong; Samuel C Mok
Identification of DNA copy number changes in microdissected serous ovarian cancer tissue using a cDNA microarray platform.
Cancer genetics and cytogenetics 2004;155(2):97-107.
2004: Yvonne T M Tsang; Yi-Mieng Chang; Xinyan Lu; Pulivarthi H Rao; Ching C Lau; Kwong-Kwok Wong
Amplification of MGC2177, PLAG1, PSMC6P, and LYN in a malignant mixed tumor of salivary gland detected by cDNA microarray with tyramide signal amplification.
Cancer genetics and cytogenetics 2004;152(2):124-8.
2004: Kwong-Kwok Wong; Yvonne T M Tsang; Jianhe Shen; Rita S Cheng; Yi-Mieng Chang; Tsz-Kwong Man; Ching C Lau
Allelic imbalance analysis by high-density single-nucleotide polymorphic allele (SNP) array with whole genome amplified DNA.
Nucleic acids research 2004;32(9):e69.
2003: Jae-Hoon Kim; Dorothee Herlyn; Kwong-Kwok Wong; Dong-Choon Park; John O Schorge; Karen H Lu; Steven J Skates; Daniel W Cramer; Ross S Berkowitz; Samuel C Mok
Identification of epithelial cell adhesion molecule autoantibody in patients with ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):4782-91.
2002: Mary S Lipton; Ljiljana Pasa-Tolic'; Gordon A Anderson; David J Anderson; Deanna L Auberry; John R Battista; Michael J Daly; James K Fredrickson; Kim K Hixson; Heather M Kostandarithes; Christophe Masselon; Lye Meng Markillie; Ronald J Moore; Margaret F Romine; Yufeng Shen; Eric Stritmatter; Nikola Tolic'; Harold R Udseth; Amudhan Venkateswaran; Kwong-Kwok Wong; Rui Zhao; Richard D Smith
Global analysis of the Deinococcus radiodurans proteome by using accurate mass tags.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11049-54.
2002: Jae-Hoon Kim; Steven J Skates; Toshimitsu Uede; Kwong-Kwok Wong; John O Schorge; Colleen M Feltmate; Ross S Berkowitz; Daniel W Cramer; Samuel C Mok
Osteopontin as a potential diagnostic biomarker for ovarian cancer.
JAMA : the journal of the American Medical Association 2002;287(13):1671-9.
1998: Samuel C Mok; W Y Chan; Kwong-Kwok Wong; K K Cheung; CC Lau; Shu-Wing Ng; A Baldini; CV Colitti; C O Rock; Ross S Berkowitz
DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer.
Oncogene 1998;16(18):2381-7.